13674-87-8 | 2-Propanol, 1,3-dichloro-, 2,2',2''-phosphate

Packsize	Purity	Availability	Price	Discounted Price
5g	90%	in stock	$31.00	$22.00
25g	90%	in stock	$47.00	$33.00
100g	90%	in stock	$139.00	$97.00
500g	90%	in stock	$163.00	$114.00

Description

• Catalog Number: AA49444
• Chemical Name: 2-Propanol, 1,3-dichloro-, 2,2',2''-phosphate
• CAS Number: 13674-87-8
• Molecular Formula: C9H15Cl6O4P
• Molecular Weight: 430.9048
• MDL Number: MFCD00083121
• SMILES: ClCC(OP(=O)(OC(CCl)CCl)OC(CCl)CCl)CCl

Computed Properties

• Complexity: 243
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 12
• XLogP3: 3.3

Literature

• Real-time PCR array to study the effects of chemicals on the growth hormone/insulin-like growth factors (GH/IGFs) axis of zebrafish embryos/larvae.

  Chemosphere 20180901

• Organophosphate Flame-Retardants Alter Adult Mouse Homeostasis and Gene Expression in a Sex-Dependent Manner Potentially Through Interactions With ERα.

  Toxicological sciences : an official journal of the Society of Toxicology 20180301

• Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells.

  Environmental toxicology 20170601

• Parental transfer of tris(1,3-dichloro-2-propyl) phosphate and transgenerational inhibition of growth of zebrafish exposed to environmentally relevant concentrations.

  Environmental pollution (Barking, Essex : 1987) 20170101

• Tris (1,3-dichloro-2-propyl) phosphate-induced apoptotic signaling pathways in SH-SY5Y neuroblastoma cells.

  Neurotoxicology 20170101

• Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity.

  Journal of applied toxicology : JAT 20160501

• The Flame-Retardant Tris(1,3-dichloro-2-propyl) Phosphate Represses Androgen Signaling in Human Prostate Cancer Cell Lines.

  Journal of biochemical and molecular toxicology 20160501

• Use of a Novel Double-Crested Cormorant ToxChip PCR Array and the EROD Assay to Determine Effects of Environmental Contaminants in Primary Hepatocytes.

  Environmental science & technology 20160315

• Effects of primary metabolites of organophosphate flame retardants on transcriptional activity via human nuclear receptors.

  Toxicology letters 20160314

• Thyroid hormone-disrupting activity and ecological risk assessment of phosphorus-containing flame retardants by in vitro, in vivo and in silico approaches.

  Environmental pollution (Barking, Essex : 1987) 20160301

• Targeting neurotrophic factors and their receptors, but not cholinesterase or neurotransmitter, in the neurotoxicity of TDCPP in Chinese rare minnow adults (Gobiocypris rarus).

  Environmental pollution (Barking, Essex : 1987) 20160101

• Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish.

  Scientific reports 20160101

• Environmentally Relevant Concentrations of the Flame Retardant Tris(1,3-dichloro-2-propyl) Phosphate Inhibit Growth of Female Zebrafish and Decrease Fecundity.

  Environmental science & technology 20151215

• Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae.

  Environmental science & technology 20150421

• Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: estrogenic activity, endocrine disruption and reproductive effects on zebrafish.

  Aquatic toxicology (Amsterdam, Netherlands) 20150301

• Bioconcentration, metabolism and neurotoxicity of the organophorous flame retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to zebrafish.

  Aquatic toxicology (Amsterdam, Netherlands) 20150101

• Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.

  International journal of molecular sciences 20150101

• Neurotoxicological and thyroid evaluations of rats developmentally exposed to tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris(2-chloro-2-ethyl)phosphate (TCEP).

  Neurotoxicology and teratology 20150101

• Developmental exposure to organophosphate flame retardants elicits overt toxicity and alters behavior in early life stage zebrafish (Danio rerio).

  Toxicological sciences : an official journal of the Society of Toxicology 20141201

• Time-dependent effects of the flame retardant tris(1,3-dichloro-2-propyl) phosphate (TDCPP) on mRNA expression, in vitro and in ovo, reveal optimal sampling times for rapidly metabolized compounds.

  Environmental toxicology and chemistry 20141201

• Potential estrogenic effects of phosphorus-containing flame retardants.

  Environmental science & technology 20140617

• Toxicity of TDCPP and TCEP on PC12 cell: changes in CAMKII, GAP43, tubulin and NF-H gene and protein levels.

  Toxicology letters 20140616

• Multiple bio-analytical methods to reveal possible molecular mechanisms of developmental toxicity in zebrafish embryos/larvae exposed to tris(2-butoxyethyl) phosphate.

  Aquatic toxicology (Amsterdam, Netherlands) 20140501

• Use of an avian hepatocyte assay and the avian Toxchip Polymerse chain reaction array for testing prioritization of 16 organic flame retardants.

  Environmental toxicology and chemistry 20140301

• Tris(1,3-dichloro-2-propyl) phosphate perturbs the expression of genes involved in immune response and lipid and steroid metabolism in chicken embryos.

  Toxicology and applied pharmacology 20140301

• In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors.

  Toxicology 20131206

• Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of developmental toxicity.

  Environmental science & technology 20130917

• In Ovo effects of two organophosphate flame retardants--TCPP and TDCPP--on pipping success, development, mRNA expression, and thyroid hormone levels in chicken embryos.

  Toxicological sciences : an official journal of the Society of Toxicology 20130701

• Effects of TDCPP or TPP on gene transcriptions and hormones of HPG axis, and their consequences on reproduction in adult zebrafish (Danio rerio).

  Aquatic toxicology (Amsterdam, Netherlands) 20130615

• Similarities in the endocrine-disrupting potencies of indoor dust and flame retardants by using human osteosarcoma (U2OS) cell-based reporter gene assays.

  Environmental science & technology 20130319

• Effects of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate on receptor-associated mRNA expression in zebrafish embryos/larvae.

  Aquatic toxicology (Amsterdam, Netherlands) 20130315

• Early zebrafish embryogenesis is susceptible to developmental TDCPP exposure.

  Environmental health perspectives 20121101

• Concentrations of organophosphate esters and brominated flame retardants in German indoor dust samples.

  Journal of environmental monitoring : JEM 20120901

• Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis.

  Chemosphere 20120801

• Levels and distributions of organophosphate flame retardants and plasticizers in sediment from Taihu Lake, China.

  Environmental toxicology and chemistry 20120701

• Indoor air in schools and lung function of Austrian school children.

  Journal of environmental monitoring : JEM 20120701

• Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish.

  Aquatic toxicology (Amsterdam, Netherlands) 20120615

• Effects of tris(1,3-dichloro-2-propyl) phosphate and tris(1-chloropropyl) phosphate on cytotoxicity and mRNA expression in primary cultures of avian hepatocytes and neuronal cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20120301

• Complete detoxification of tris(1,3-dichloro-2-propyl) phosphate by mixed two bacteria, Sphingobium sp. strain TCM1 and Arthrobacter sp. strain PY1.

  Journal of bioscience and bioengineering 20120101

• Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells.

  Toxicology and applied pharmacology 20111101

• Brominated and organophosphate flame retardants in selected consumer products on the Japanese market in 2008.

  Journal of hazardous materials 20110915

• Identification of flame retardants in polyurethane foam collected from baby products.

  Environmental science & technology 20110615

• House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters.

  Environmental health perspectives 20100301

• Endocrine damper? Flame retardants linked to male hormone, sperm count changes.

  Environmental health perspectives 20100301

• Seasonal fluctuations of organophosphate concentrations in precipitation and storm water runoff.

  Chemosphere 20100201

• Discontinued pajama flame retardant detected in baby products and house dust.

  Environmental science & technology 20091001

• Detection of organophosphate flame retardants in furniture foam and U.S. house dust.

  Environmental science & technology 20091001

• Enrichment and characterization of chlorinated organophosphate ester-degrading mixed bacterial cultures.

  Journal of bioscience and bioengineering 20080701

• Organophosphate flame retardants and plasticizers in indoor air.

  Chemosphere 20041101

• Estimation of organophosphoric acid triesters in soft polyurethane foam using a concentrated sulfuric acid dissolution technique and gas chromatography with flame photometric detection.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20031201

• In vitro dermal absorption of flame retardant chemicals.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20011201

• Comparative genotoxicity and nephrotoxicity studies of the two halogenated flame retardants tris(1,3-dichloro-2-propyl)phosphate and tris(2,3-dibromopropyl)phosphate.

  Acta pharmacologica et toxicologica 19850101