13677-79-7 | 3,4,5-Trihydroxybenzaldehyde

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$8.00	$6.00
250mg	98%	in stock	$12.00	$9.00
1g	98%	in stock	$32.00	$22.00
5g	98%	in stock	$114.00	$80.00
10g	98%	in stock	$190.00	$133.00
25g	98%	in stock	$341.00	$239.00
100g	98%	in stock	$913.00	$639.00

Description

• Catalog Number: AA49491
• Chemical Name: 3,4,5-Trihydroxybenzaldehyde
• CAS Number: 13677-79-7
• Molecular Formula: C7H6O4
• Molecular Weight: 154.1201
• MDL Number: MFCD00003371
• SMILES: O=Cc1cc(O)c(c(c1)O)O
• NSC Number: 153692

Computed Properties

• Complexity: 135
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1
• XLogP3: 0.6

Upstream Synthesis Route

3,4,5-Trihydroxybenzaldehyde, also known as trihydroxybenzaldehyde or gallic aldehyde, is a versatile compound widely used in chemical synthesis. One of its primary applications is as a key intermediate in the synthesis of pharmaceuticals and natural products. In chemical synthesis, 3,4,5-trihydroxybenzaldehyde serves as a valuable building block for the creation of various organic compounds. Its unique structure containing three hydroxyl groups allows for diverse chemical reactions, including esterification, alkylation, and oxidation, leading to the formation of complex molecules with biological activities.Furthermore, 3,4,5-trihydroxybenzaldehyde is utilized in the production of specialty chemicals, such as dyes, perfumes, and flavoring agents. Its aromatic nature imparts a pleasant scent and taste, making it a popular choice in the fragrance and food industries.Overall, the application of 3,4,5-trihydroxybenzaldehyde in chemical synthesis is essential for the development of new compounds with medicinal, industrial, and consumer applications.

Literature

• Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris.

  Fitoterapia 20140601

• Comprehensive chemical profiling of guizhi fuling capsule by the combined use of gas chromatography-mass spectrometry with a deconvolution software and rapid-resolution liquid chromatography quadrupole time-of-flight tandem mass spectrometry.

  Biomedical chromatography : BMC 20121001

• Inhibition of the intracellular Ca(2+) transporter SERCA (Sarco-Endoplasmic Reticulum Ca(2+)-ATPase) by the natural polyphenol epigallocatechin-3-gallate.

  Journal of bioenergetics and biomembranes 20121001

• Catechins containing a galloyl moiety as potential anti-HIV-1 compounds.

  Drug discovery today 20120601

• Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris.

  Biotechnology letters 20120501

• Cytotoxicity and structure activity relationship studies of maplexins A-I, gallotannins from red maple (Acer rubrum).

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

• Identification and characterization of proanthocyanidins of 16 members of the Rhododendron genus (Ericaceae) by tandem LC-MS.

  Journal of mass spectrometry : JMS 20120401

• Interaction of tea polyphenols and food constituents with model gut epithelia: the protective role of the mucus gel layer.

  Journal of agricultural and food chemistry 20120328

• Dietary flavan-3-ols intake and metabolic syndrome risk in Korean adults.

  Nutrition research and practice 20120201

• Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stems.

  Bioorganic & medicinal chemistry letters 20120101

• New identification of proanthocyanidins in cinnamon (Cinnamomum zeylanicum L.) using MALDI-TOF/TOF mass spectrometry.

  Analytical and bioanalytical chemistry 20120101

• [Mechanism of interaction between risperidone and tea catechin (2) influence of presence of galloyl group in catechin on insoluble complex formation with risperidone].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101

• Effect of acute administration of Pistacia lentiscus L. essential oil on rat cerebral cortex following transient bilateral common carotid artery occlusion.

  Lipids in health and disease 20120101

• Dissecting genetic architecture of grape proanthocyanidin composition through quantitative trait locus mapping.

  BMC plant biology 20120101

• New galloyl derivative from winged sumac (Rhus copallinum) fruit.

  Natural product communications 20120101

• Effect of mineral-enriched diet and medicinal herbs on Fe, Mn, Zn, and Cu uptake in chicken.

  Chemistry Central journal 20120101

• Antioxidant activities and phytochemical study of leaf extracts from 18 indigenous tree species in taiwan.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Phyllanthus urinaria Induces Apoptosis in Human Osteosarcoma 143B Cells via Activation of Fas/FasL- and Mitochondria-Mediated Pathways.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis.

  PloS one 20120101

• Relationship between the composition of flavonoids and flower colors variation in tropical water lily (Nymphaea) cultivars.

  PloS one 20120101

• A gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze displays cytotoxic activity and raises sensitivity to doxorubicin in a leukemia cell line.

  BMC complementary and alternative medicine 20120101

• Lipid-regulating effect of traditional chinese medicine: mechanisms of actions.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Gelatin tannate reduces the proinflammatory effects of lipopolysaccharide in human intestinal epithelial cells.

  Clinical and experimental gastroenterology 20120101

• Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Phytochemicals and biological studies of plants from the genus Balanophora.

  Chemistry Central journal 20120101

• Influence of galloyl moiety in interaction of epicatechin with bovine serum albumin: a spectroscopic and thermodynamic characterization.

  PloS one 20120101

• Incompatibility between propericiazine oral solution and tea-based drink.

  Chemical & pharmaceutical bulletin 20120101

• Gallated form of tea catechin, not nongallated form, increases fecal starch excretion in rats.

  Journal of nutritional science and vitaminology 20120101

• Identification of new natural sweet compounds in wine using centrifugal partition chromatography-gustatometry and Fourier transform mass spectrometry.

  Analytical chemistry 20111215

• In vitro human skin permeation and cutaneous metabolism of catechins from green tea extract and green tea extract-loaded chitosan microparticles.

  International journal of cosmetic science 20111201

• Triterpene hexahydroxydiphenoyl esters and a quinic acid purpurogallin carbonyl ester from the leaves of Castanopsis fissa.

  Phytochemistry 20111101

• Effect of some naturally occurring iron ion chelators on the formation of radicals in the reaction mixtures of rat liver microsomes with ADP, Fe and NADPH.

  Journal of clinical biochemistry and nutrition 20111101

• Simple solution for a complex problem: proanthocyanidins, galloyl glucoses and ellagitannins fit on a single calibration curve in high performance-gel permeation chromatography.

  Journal of chromatography. A 20111028

• An amphiphilic conjugate approach toward the design and synthesis of betulinic acid-polyphenol conjugates as inhibitors of the HIV-1 gp41 fusion core formation.

  ChemMedChem 20110905

• Inhibition effects of the classical pathway complement of isolated compounds from Quercus glauca.

  Human & experimental toxicology 20110901

• Flavonoids in prevention of diseases with respect to modulation of Ca-pump function.

  Interdisciplinary toxicology 20110901

• Phenolic compounds from Byrsonima crassifolia L. bark: phytochemical investigation and quantitative analysis by LC-ESI MS/MS.

  Journal of pharmaceutical and biomedical analysis 20110825

• Investigation on the phenolic constituents in Hamamelis virginiana leaves by HPLC-DAD and LC-MS/MS.

  Analytical and bioanalytical chemistry 20110801

• Gallates of isoorientin and (2S)-1,2-propanediol glucoside from the leaves of Schoepfia jasminodora.

  Journal of natural medicines 20110701

• Interaction of epicatechin gallate with phospholipid membranes as revealed by solid-state NMR spectroscopy.

  Biochimica et biophysica acta 20110601

• Interaction of natural polyphenols with α-amylase in vitro: molecular property-affinity relationship aspect.

  Molecular bioSystems 20110601

• Galloylated polyphenols as inhibitors of hemoglobin-catalyzed lipid oxidation in fish muscle.

  Journal of agricultural and food chemistry 20110525

• Caffeic acid inhibits the formation of 1-hydroxyethyl radical in the reaction mixture of rat liver microsomes with ethanol partly through its metal chelating activity.

  Journal of clinical biochemistry and nutrition 20110501

• Conformation of the tridimensional structure of 1,2,3,4,6-pentagalloyl-β-D-glucopyranose (PGG) by (1)H NMR, NOESY and theoretical study and membrane interaction in a simulated phospholipid bilayer: a first insight.

  Magnetic resonance in chemistry : MRC 20110301

• Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39.

  Biochemical and biophysical research communications 20110225

• [Adsorption kinetic study of the interaction between human salivary alpha-amylase and the polyphenoles from the black/green tea].

  Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 20110201

• Health-Beneficial Phenolic Aldehyde in Antigonon leptopus Tea.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Ellagic Acid, the Active Compound of Phyllanthus urinaria, Exerts In Vivo Anti-Angiogenic Effect and Inhibits MMP-2 Activity.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Protective Mechanism of KIOM-4 in Streptozotocin-Induced Pancreatic β-Cells Damage Is Involved in the Inhibition of Endoplasmic Reticulum Stress.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Human serum albumin as an antioxidant in the oxidation of (-)-epigallocatechin gallate: participation of reversible covalent binding for interaction and stabilization.

  Bioscience, biotechnology, and biochemistry 20110101

• Galloyl glucoses from the seeds of Cornus officinalis with inhibitory activity against protein glycation, aldose reductase, and cataractogenesis ex vivo.

  Biological & pharmaceutical bulletin 20110101

• Pycnalin, a new α-glucosidase inhibitor from Acer pycnanthum.

  Chemical & pharmaceutical bulletin 20110101

• Differences and similarities of postprandial lipemia in rodents and humans.

  Lipids in health and disease 20110101

• Preventive effect of pine bark extract (flavangenol) on metabolic disease in Western diet-loaded tsumura suzuki obese diabetes mice.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• The inhibition of lipase and glucosidase activities by acacia polyphenol.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Bio::Homology::InterologWalk--a Perl module to build putative protein-protein interaction networks through interolog mapping.

  BMC bioinformatics 20110101

• Green tea extract for periodontal health.

  Journal of Indian Society of Periodontology 20110101

• KIOM-4 Protects against Oxidative Stress-Induced Mitochondrial Damage in Pancreatic β-cells via Its Antioxidant Effects.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Analysis of the mechanism of inhibition of human matrix metalloproteinase 7 (MMP-7) activity by green tea catechins.

  Bioscience, biotechnology, and biochemistry 20110101

• Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population.

  BMC cancer 20110101

• Novel strategies for upstream and downstream processing of tannin acyl hydrolase.

  Enzyme research 20110101

• Proanthocyanidins modulate microRNA expression in human HepG2 cells.

  PloS one 20110101

• Characterization of gallotannins from Astronium species by flow injection analysis- electrospray ionization-ion trap-tandem mass spectrometry and matrix-assisted laser desorption/ionization time-of- flight mass spectrometry.

  European journal of mass spectrometry (Chichester, England) 20110101

• Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises?

  International journal of molecular sciences 20110101

• Enhancement of antimicrobial activities of whole and sub-fractionated white tea by addition of copper (II) sulphate and vitamin C against Staphylococcus aureus; a mechanistic approach.

  BMC complementary and alternative medicine 20110101

• Antioxidant and antibacterial properties of green, black, and herbal teas of Camellia sinensis.

  Pharmacognosy research 20110101

• The relationships between biological activities and structure of flavan-3-ols.

  International journal of molecular sciences 20110101

• Effects of some common food constituents on cardiovascular disease.

  ISRN cardiology 20110101

• Oolong tea theasinensins attenuate cyclooxygenase-2 expression in lipopolysaccharide (LPS)-activated mouse macrophages: structure-activity relationship and molecular mechanisms.

  Journal of agricultural and food chemistry 20101222

• The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors.

  Clinical immunology (Orlando, Fla.) 20101201

• New galloylated flavanonols from the Australian plant Glochidion sumatranum.

  Planta medica 20101101

• [Mechanism of interaction between risperidone and tea catechin(1)complex formation of risperidone with epigallocatechin gallate].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20101101

• Activity-guided isolation and identification of radical scavenging components in Gao-Cha tea.

  Journal of food science 20101001

• Phenolic compounds in chestnut (Castanea sativa Mill.) heartwood. Effect of toasting at cooperage.

  Journal of agricultural and food chemistry 20100908

• Synthesis and antioxidant activity of new pyridines containing gallate moieties.

  Archiv der Pharmazie 20100901

• The polyphenol epigallocatechin-3-gallate affects lipid rafts to block activation of the c-Met receptor in prostate cancer cells.

  Molecular carcinogenesis 20100801

• Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2.

  The Journal of biological chemistry 20100730

• Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin.

  Bioorganic & medicinal chemistry 20100715

• New benzophenone and quercetin galloyl glycosides from Psidium guajava L.

  Journal of natural medicines 20100701

• Simultaneous determination of hydrolysable tannins in the petals of Rosa rugosa and allied plants.

  Journal of natural medicines 20100701

• Dietary polyphenols and obesity.

  Nutrients 20100701

• Cloning of a novel O-methyltransferase from Camellia sinensis and synthesis of o-methylated EGCG and evaluation of their bioactivity.

  Journal of agricultural and food chemistry 20100623

• Contribution of galloylation and polymerization to the antioxidant activity of polyphenols in fish lipid systems.

  Journal of agricultural and food chemistry 20100623

• Binding affinity of tea catechins for HSA: characterization by high-performance affinity chromatography with immobilized albumin column.

  Molecular nutrition & food research 20100601

• Hydrolyzable tannins of tamaricaceous plants. III. Hellinoyl- and macrocyclic-type ellagitannins from Tamarix nilotica.

  Journal of natural products 20100528

• Interactive intoxicating and ameliorating effects of tannic acid, aluminum (Al), copper (Cu), and selenate (SeO) in wheat roots: a descriptive and mathematical assessment.

  Physiologia plantarum 20100501

• Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro.

  British journal of cancer 20100427

• One new galloyl glycoside from fresh leaves of Psidium guajava L.

  Yao xue xue bao = Acta pharmaceutica Sinica 20100301

• Antioxidant properties and neuroprotective capacity of strawberry tree fruit (Arbutus unedo).

  Nutrients 20100201

• Fractionation of Gallotannins from mango (Mangifera indica L.) kernels by high-speed counter-current chromatography and determination of their antibacterial activity.

  Journal of agricultural and food chemistry 20100127

• Structural characteristics for superoxide anion radical scavenging and productive activities of green tea polyphenols including proanthocyanidin dimers.

  Chemical & pharmaceutical bulletin 20100101

• Phenolic inhibitors of chemical and enzymatic oxidation in the leaves of Myrica rubra.

  Bioscience, biotechnology, and biochemistry 20100101

• Chemistry of secondary polyphenols produced during processing of tea and selected foods.

  International journal of molecular sciences 20100101

• Structural features and biological properties of ellagitannins in some plant families of the order Myrtales.

  International journal of molecular sciences 20100101

• Epimerization of tea catechins under weakly acidic and alkaline conditions.

  Bioscience, biotechnology, and biochemistry 20100101

• Flavanols and anthocyanins in cardiovascular health: a review of current evidence.

  International journal of molecular sciences 20100101

• Robinetinidol-(4beta-->8)-epigallocatechin 3-O-gallate, a galloyl dimer prorobinetinidin from Acacia mearnsii De Wild, effectively protects human neuroblastoma SH-SY5Y cells against acrolein-induced oxidative damage.

  Journal of Alzheimer's disease : JAD 20100101

• Structured triacylglycerol containing behenic and oleic acids suppresses triacylglycerol absorption and prevents obesity in rats.

  Lipids in health and disease 20100101

• Green tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-I.

  PloS one 20100101

• The inhibitory effects of catechins on biofilm formation by the periodontopathogenic bacterium, Eikenella corrodens.

  Bioscience, biotechnology, and biochemistry 20100101

• Influence of the galloyl moiety in tea catechins on binding affinity for human serum albumin.

  Journal of nutritional science and vitaminology 20100101

• Antioxidant and biological properties of bioactive phenolic compounds from Quercus suber L.

  Journal of agricultural and food chemistry 20091209

• Galloyl and hexahydroxydiphenoyl esters of phenylpropanoid glucosides, phenylpropanoids and phenylpropanoid glucosides from rhizome of Balanophora fungosa.

  Chemical & pharmaceutical bulletin 20091201

• Chelation of Cu(II), Zn(II), and Fe(II) by tannin constituents of selected edible nuts.

  International journal of molecular sciences 20091201

• Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase.

  PLoS currents 20091013

• Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells.

  Chemico-biological interactions 20090914

• Androgen modulators from the roots of Paeonia lactiflora (paeoniae radix) grown and processed in nara prefecture, Japan.

  Chemical & pharmaceutical bulletin 20090901

• Black-tea polyphenols suppress postprandial hypertriacylglycerolemia by suppressing lymphatic transport of dietary fat in rats.

  Journal of agricultural and food chemistry 20090812

• Coupling reactions of catechins with natural aldehydes and allyl alcohols and radical scavenging activities of the triglyceride-soluble products.

  Journal of agricultural and food chemistry 20090722

• Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway.

  Biochemical pharmacology 20090701

• Galloylated polyphenols efficiently reduce alpha-tocopherol radicals in a phospholipid model system composed of sodium dodecyl sulfate (SDS) micelles.

  Journal of agricultural and food chemistry 20090610

• Disruption of D-alanyl esterification of Staphylococcus aureus cell wall teichoic acid by the {beta}-lactam resistance modifier (-)-epicatechin gallate.

  The Journal of antimicrobial chemotherapy 20090601

• Impact of linker strain and flexibility in the design of a fragment-based inhibitor.

  Nature chemical biology 20090601

• Stilbene synthase gene transfer caused alterations in the phenylpropanoid metabolism of transgenic strawberry (Fragaria x ananassa).

  Journal of experimental botany 20090501

• Identification of multiple constituents in the traditional Chinese medicine formula GuiZhiFuLing-Wan by HPLC-DAD-MS/MS.

  Journal of pharmaceutical and biomedical analysis 20090220

• Chemical profiling of Radix Paeoniae evaluated by ultra-performance liquid chromatography/photo-diode-array/quadrupole time-of-flight mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20090220

• Structure-activity relationship of bis-galloyl derivatives related to (-)-epigallocatechin gallate.

  Chemical & pharmaceutical bulletin 20090201

• Preclinical development of the green tea catechin, epigallocatechin gallate, as an HIV-1 therapy.

  The Journal of allergy and clinical immunology 20090201

• High-speed separation and characterization of major constituents in Radix Paeoniae Rubra by fast high-performance liquid chromatography coupled with diode-array detection and time-of-flight mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20090101

• The Association between Concentrations of Green Tea and Blood Glucose Levels.

  Journal of clinical biochemistry and nutrition 20090101

• Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines.

  The Journal of nutritional biochemistry 20081201

• Role of catechin quinones in the induction of EpRE-mediated gene expression.

  Chemical research in toxicology 20081201

• Medicinal flowers. XXIII. New taraxastane-type triterpene, punicanolic acid, with tumor necrosis factor-alpha inhibitory activity from the flowers of Punica granatum.

  Chemical & pharmaceutical bulletin 20081101

• 3,4,5-trihydroxybenzaldehyde from Geum japonicum has dual inhibitory effect on matrix metalloproteinase 9; inhibition of gelatinoytic activity as well as MMP-9 expression in TNF-alpha induced HASMC.

  Journal of cellular biochemistry 20081001

• Ethnopharmacology.

  Indian journal of pharmacology 20081001

• Structure-activity relationships of flavonoids in the cellular antioxidant activity assay.

  Journal of agricultural and food chemistry 20080924

• Absorption and pharmacokinetics of green tea catechins in beagles.

  The British journal of nutrition 20080901

• Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallate.

  Bioorganic & medicinal chemistry 20080901

• Isolation and structure of whiskey polyphenols produced by oxidation of oak wood ellagitannins.

  Journal of agricultural and food chemistry 20080827

• The impact of the 67kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins.

  Archives of biochemistry and biophysics 20080815

• Is the combination of sulfonylureas and metformin associated with an increased risk of cardiovascular disease or all-cause mortality?: a meta-analysis of observational studies.

  Diabetes care 20080801

• Antioxidative activities of galloyl glucopyranosides from the stem-bark of Juglans mandshurica.

  Bioscience, biotechnology, and biochemistry 20080801

• Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells.

  Biological & pharmaceutical bulletin 20080701

• Azuki bean juice lowers serum triglyceride concentrations in healthy young women.

  Journal of clinical biochemistry and nutrition 20080701

• Oxidation of ingested phenolics in the tree-feeding caterpillar Orgyia leucostigma depends on foliar chemical composition.

  Journal of chemical ecology 20080601

• Generation of mouse monoclonal antibody against (-)-epigallocatechin gallate.

  Biological & pharmaceutical bulletin 20080501

• The primary headaches: genetics, epigenetics and a behavioural genetic model.

  The journal of headache and pain 20080401

• Green tea catechin as a chemical chaperone in cancer prevention.

  Cancer letters 20080308

• Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi.

  Bioorganic & medicinal chemistry letters 20080301

• Polymer-like polyphenols of black tea and their lipase and amylase inhibitory activities.

  Chemical & pharmaceutical bulletin 20080301

• pH-Dependent radical scavenging capacity of green tea catechins.

  Journal of agricultural and food chemistry 20080213

• Effect of phenolic aldehydes and flavonoids on growth and inactivation of Oenococcus oeni and Lactobacillus hilgardii.

  Food microbiology 20080201

• Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity.

  Journal of cardiovascular pharmacology 20080101

• Multifunctional effects of green tea catechins on prevention of the metabolic syndrome.

  Asia Pacific journal of clinical nutrition 20080101

• Structures of epicatechin gallate trimer and tetramer produced by enzymatic oxidation.

  Chemical & pharmaceutical bulletin 20071201

• Antidiabetes and Anti-obesity Activity of Lagerstroemia speciosa.

  Evidence-based complementary and alternative medicine : eCAM 20071201

• Dynamic behavior of tea catechins interacting with lipid membranes as determined by NMR spectroscopy.

  Journal of agricultural and food chemistry 20071128

• Epigallocatechin gallate-induced apoptosis does not affect adipocyte conversion of preadipocytes.

  Cell biology international 20071101

• Interaction of different polyphenols with bovine serum albumin (BSA) and human salivary alpha-amylase (HSA) by fluorescence quenching.

  Journal of agricultural and food chemistry 20070808

• Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3'-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells.

  Carcinogenesis 20070701

• Inhibition of P-glycoprotein function by tannic acid and pentagalloylglucose.

  The Journal of pharmacy and pharmacology 20070701

• Investigation of adsorption behavior of (-)-epigallocatechin gallate on bovine serum albumin surface using quartz crystal microbalance with dissipation monitoring.

  Journal of agricultural and food chemistry 20070627

• Structure-activity relationship of flavonoids for inhibition of epidermal growth factor-induced transformation of JB6 Cl 41 cells.

  Molecular carcinogenesis 20070601

• Morphology and biochemistry of non-glandular trichomes in Cistus salvifolius L. leaves growing in extreme habitats of the Mediterranean basin.

  Plant biology (Stuttgart, Germany) 20070501

• Profiling and characterization by LC-MSn of the galloylquinic acids of green tea, tara tannin, and tannic acid.

  Journal of agricultural and food chemistry 20070418

• Green tea proanthocyanidins inhibit cyclooxygenase-2 expression in LPS-activated mouse macrophages: molecular mechanisms and structure-activity relationship.

  Archives of biochemistry and biophysics 20070401

• Oxidative coupling of the pyrogallol B-ring with a galloyl group during enzymatic oxidation of epigallocatechin 3-O-gallate.

  Phytochemistry 20070401

• Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure.

  European journal of nutrition 20070401

• Aromatic diglycosides from Cladogynos orientalis.

  Phytochemistry 20070301

• High-molecular-weight polyphenols from oolong tea and black tea: purification, some properties, and role in increasing mitochondrial membrane potential.

  Bioscience, biotechnology, and biochemistry 20070301

• Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site.

  Journal of medicinal chemistry 20070125

• Molecular targets of tea polyphenols in the cardiovascular system.

  Cardiovascular research 20070115

• Prediction of binding for a kind of non-peptic HCV NS3 serine protease inhibitors from plants by molecular docking and MM-PBSA method.

  Bioorganic & medicinal chemistry 20070101

• Galloyl depsides of tyrosine from young leaves of Inga laurina.

  Journal of natural products 20070101

• Liquid chromatography/electrospray ionization tandem mass spectrometry profiling of compounds from the infusion of Byrsonima fagifolia Niedenzu.

  Rapid communications in mass spectrometry : RCM 20070101

• Isolation and characterisation of procyanidins from Rumex obtusifolius.

  Phytochemical analysis : PCA 20070101

• Monomers of condensed tannins affect the larval exsheathment of parasitic nematodes of ruminants.

  Journal of agricultural and food chemistry 20061004

• Ellagitannins have greater oxidative activities than condensed tannins and galloyl glucoses at high pH: potential impact on caterpillars.

  Journal of chemical ecology 20061001

• Tannin composition affects the oxidative activities of tree leaves.

  Journal of chemical ecology 20061001

• DNA and RNA as new binding targets of green tea catechins.

  The Journal of biological chemistry 20060623

• Epicatechins Purified from Green Tea (Camellia sinensis) Differentially Suppress Growth of Gender-Dependent Human Cancer Cell Lines.

  Evidence-based complementary and alternative medicine : eCAM 20060601

• Synthesis and structure-activity relationship study of antidiabetic penta-O-galloyl-D-glucopyranose and its analogues.

  Journal of medicinal chemistry 20060504

• Evaluation of antiherpetic activity and genotoxic effects of tea catechin derivatives.

  Journal of agricultural and food chemistry 20060405

• The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells.

  Oncogene 20060323

• Inhibition of leukocyte elastase, polymorphonuclear chemoinvasion, and inflammation-triggered pulmonary fibrosis by a 4-alkyliden-beta-lactam with a galloyl moiety.

  The Journal of pharmacology and experimental therapeutics 20060201

• Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity.

  The European journal of neuroscience 20060101

• Characterization of compounds in the Chinese herbal drug Mu-Dan-Pi by liquid chromatography coupled to electrospray ionization mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20060101

• A novel black tea pigment and two new oxidation products of epigallocatechin-3-O-gallate.

  Journal of agricultural and food chemistry 20050921

• MALDI-TOF mass spectrometry of oligomeric food polyphenols.

  Phytochemistry 20050901

• Antioxidant properties of two gallotannins isolated from the leaves of Pistacia weinmannifolia.

  Biochimica et biophysica acta 20050830

• Non-covalent interaction between procyanidins and apple cell wall material. Part II: Quantification and impact of cell wall drying.

  Biochimica et biophysica acta 20050830

• Inhibitory effects of catechin gallates on o-methyltranslation of protocatechuic acid in rat liver cytosolic preparations and cultured hepatocytes.

  Biological & pharmaceutical bulletin 20050801

• Dose-dependent suppression of tea catechins with a galloyl moiety on postprandial hypertriglyceridemia in rats.

  Bioscience, biotechnology, and biochemistry 20050701

• Structure determination of bioactive galloyl derivatives by NMR spectroscopy.

  Magnetic resonance in chemistry : MRC 20050601

• Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro.

  Journal of agricultural and food chemistry 20050601

• Green tea catechins containing a galloyl group in the 3' position inhibit tissue factor-induced thrombin generation.

  Thrombosis and haemostasis 20050601

• Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41.

  Biochimica et biophysica acta 20050525

• Suppression of tumor cell invasiveness by hydrolyzable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity.

  Biochemical and biophysical research communications 20050520

• Synthesis and antibacterial activity of hydrolytically stable (-)-epicatechin gallate analogues for the modulation of beta-lactam resistance in Staphylococcus aureus.

  Bioorganic & medicinal chemistry letters 20050516

• Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases.

  Bioorganic & medicinal chemistry 20050415

• Galloyl, caffeoyl and hexahydroxydiphenoyl esters of dihydrochalcone glucosides from Balanophora tobiracola.

  Phytochemistry 20050301

• Application of liquid chromatography/electrospray ionization tandem mass spectrometry to the analysis of polyphenolic compounds from an infusion of Byrsonima crassa Niedenzu.

  Rapid communications in mass spectrometry : RCM 20050101

• Binding energy of tea catechin/caffeine complexes in water evaluated by titration experiments with 1H-NMR.

  Bioscience, biotechnology, and biochemistry 20041201

• Glucuronidation of the green tea catechins, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate, by rat hepatic and intestinal microsomes.

  Free radical research 20040901

• Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells.

  The Journal of pharmacy and pharmacology 20040801

• Antioxidant properties of phenolic compounds from Pelargonium reniforme.

  Journal of agricultural and food chemistry 20040728

• Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase.

  The Journal of biological chemistry 20040723

• New non-nucleoside inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

  Biochemistry. Biokhimiia 20040701

• Tea polyphenols inhibit acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and platelet-activating factor-induced platelet aggregation.

  International archives of allergy and immunology 20040501

• Anti-genotoxic effects of tea catechins against reactive oxygen species in human lymphoblastoid cells.

  Mutation research 20040411

• Inhibitory effects of green tea polyphenols on the production of a virulence factor of the periodontal-disease-causing anaerobic bacterium Porphyromonas gingivalis.

  Journal of agricultural and food chemistry 20040324

• Long-term outcome of esophageal myotomy for achalasia.

  World journal of gastroenterology 20040115

• Mechanisms of the inhibitory effects of epigallocatechin-3 gallate on platelet-derived growth factor-BB-induced cell signaling and mitogenesis.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040101

• Evaluation of antioxidant effect of different extracts of Myrtus communis L.

  Free radical research 20040101

• Characterization of acylated flavonoid-O-glycosides and methoxylated flavonoids from Tagetes maxima by liquid chromatography coupled to electrospray ionization tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20040101

• Effect of flavan-3-ols on in vitro egg hatching, larval development and viability of infective larvae of Trichostrongylus colubriformis.

  International journal for parasitology 20031201

• The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase.

  Biochemical pharmacology 20031115

• Phenolic compounds and fatty acids from acorns (Quercus spp.), the main dietary constituent of free-ranged Iberian pigs.

  Journal of agricultural and food chemistry 20031008

• Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead.

  International journal of molecular medicine 20031001

• Structure-activity relationships in the hydrophobic interactions of polyphenols with cellulose and collagen.

  Biopolymers 20031001

• Design and development of integrase inhibitors as anti-HIV agents.

  Current medicinal chemistry 20030901

• Identification of flavonol and xanthone glycosides from mango (Mangifera indica L. Cv. 'Tommy Atkins') peels by high-performance liquid chromatography-electrospray ionization mass spectrometry.

  Journal of agricultural and food chemistry 20030813

• Toward targeted oral vaccine delivery systems: selection of lectin mimetics from combinatorial libraries.

  Pharmaceutical research 20030801

• Complex effects of different green tea catechins on human platelets.

  FEBS letters 20030710

• Anti-complement activity of constituents from the stem-bark of Juglans mandshurica.

  Biological & pharmaceutical bulletin 20030701

• Inhibitory effects of green tea catechins on protein tyrosine phosphatase in Prevotella intermedia.

  Oral microbiology and immunology 20030601

• Inhibitory effects of green tea catechins on the activity of human matrix metalloproteinase 7 (matrilysin).

  Journal of biochemistry 20030501

• Antioxidant activity of galloyl quinic derivatives isolated from P. lentiscus leaves.

  Free radical research 20030401

• Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins.

  Nutrition and cancer 20030101

• Effects of external factors on the interaction of tea catechins with lipid bilayers.

  Bioscience, biotechnology, and biochemistry 20021101

• Inhibition of lipid peroxidation and structure-activity-related studies of the dietary constituents anthocyanins, anthocyanidins, and catechins.

  Journal of agricultural and food chemistry 20020911

• Activity-guided fractionation of green tea extract with antiproliferative activity against human stomach cancer cells.

  Biological & pharmaceutical bulletin 20020901

• Anti-human immunodeficiency virus-type 1 activity of constituents from Juglans mandshurica.

  Archives of pharmacal research 20020801

• Inhibition of matrix-proteases by polyphenols: chemical insights for anti-inflammatory and anti-invasion drug design.

  Biochemical pharmacology 20020715

• Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics.

  Bioorganic & medicinal chemistry letters 20020617

• First observation of solution structures of bradykinin-penta-O-galloyl-D-glucopyranose complexes as determined by NMR and simulated annealing.

  Biochimica et biophysica acta 20020606

• Gallic esters of sucrose as efficient radical scavengers in lipid peroxidation.

  Journal of agricultural and food chemistry 20020605

• Inhibition of the PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction pathway in rat and human vascular smooth muscle cells by different catechins.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020601

• Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2).

  British journal of cancer 20020520

• Cellular thiol status-dependent inhibition of tumor cell growth via modulation of retinoblastoma protein phosphorylation by (-)-epigallocatechin.

  Cancer letters 20020508

• Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis.

  Planta medica 20020501

• New cyanogenic and alkyl glycoside constituents from Phyllagathis rotundifolia.

  Journal of natural products 20020201

• Identification and quantification of galloyl derivatives, flavonoid glycosides and anthocyanins in leaves of Pistacia lentiscus L.

  Phytochemical analysis : PCA 20020101

• Steric effects on interaction of tea catechins with lipid bilayers.

  Bioscience, biotechnology, and biochemistry 20011201

• Synthesis and conformational property of tannin-like p-tert-butylcalix[4]arene 1,3-diesters stabilized by intramolecular hydrogen bonds.

  The Journal of organic chemistry 20011130

• Nanoparticles in plant extracts--factors which influence the formation of nanoparticles in black tea infusions.

  Die Pharmazie 20011001

• Proanthocyanidins and related compounds: antileishmanial activity and modulatory effects on nitric oxide and tumor necrosis factor-alpha-release in the murine macrophage-like cell line RAW 264.7.

  Biological & pharmaceutical bulletin 20010901

• Caffeoyl, coumaroyl, galloyl, and hexahydroxydiphenoyl glucoses from Balanophora japonica.

  Chemical & pharmaceutical bulletin 20010701

• Isolation and antioxidant activity of galloyl flavonol glycosides from the seashore plant, Pemphis acidula.

  Bioscience, biotechnology, and biochemistry 20010601

• Inhibitory effects of ellagi- and gallotannins on rat intestinal alpha-glucosidase complexes.

  Bioscience, biotechnology, and biochemistry 20010301

• Structural features of procyanidin interactions with salivary proteins.

  Journal of agricultural and food chemistry 20010201

• Antioxidant constituents from rhubarb: structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides.

  Bioorganic & medicinal chemistry 20010101