13721-01-2 | 4-Oxo-1,4-dihydroquinoline-3-carboxylic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$7.00	$5.00
5g	97%	in stock	$15.00	$11.00
25g	97%	in stock	$29.00	$20.00

Description

• Catalog Number: AA50266
• Chemical Name: 4-Oxo-1,4-dihydroquinoline-3-carboxylic acid
• CAS Number: 13721-01-2
• Molecular Formula: C10H7NO3
• Molecular Weight: 189.1675
• MDL Number: MFCD00498984
• SMILES: OC(=O)c1c[nH]c2c(c1=O)cccc2
• NSC Number: 4344

Computed Properties

• Complexity: 309
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 1.8

Literature

• Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.

  ChemMedChem 20120501

• Nonclassical biological activities of quinolone derivatives.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20120101

• Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3β.

  Bioorganic & medicinal chemistry letters 20111001

• Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice.

  Journal of medicinal chemistry 20110811

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands.

  Journal of medicinal chemistry 20100826

• Tautomerism and magnesium chelation of HIV-1 integrase inhibitors: a theoretical study.

  ChemMedChem 20100705

• Dichloro-4-quinolinol-3-carboxylic acid: synthesis and antioxidant abilities to scavenge radicals and to protect methyl linoleate and DNA.

  European journal of medicinal chemistry 20100501

• Ethyl 4-(3-hydroxy-phen-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20091101

• The 4-quinolone-3-carboxylic acid motif as a multivalent scaffold in medicinal chemistry.

  Current medicinal chemistry 20090101

• Heterocycles [h]-fused onto 4-oxoquinoline-3-carboxylic acid, part VIII [1]. Convenient synthesis and antimicrobial properties of substituted hexahydro[1,4]diazepino[2,3-h]quinoline-9-carboxylic acid and its tetrahydroquino[7,8-b]benzodiazepine analog.

  Molecules (Basel, Switzerland) 20081118

• Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.

  Journal of medicinal chemistry 20080828

• Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo.

  Journal of medicinal chemistry 20080828

• Affinity of 3-acyl substituted 4-quinolones at the benzodiazepine site of GABA(A) receptors.

  Bioorganic & medicinal chemistry 20080715

• Heterocycles [h]fused onto 4-oxoquinoline-3-carboxylic acid, part IV. Convenient synthesis of substituted hexahydro [1,4]thiazepino[2,3-h]quinoline-9-carboxylic acid and its tetrahydroquino[7,8-b]benzothiazepine homolog.

  Molecules (Basel, Switzerland) 20070727

• Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2.

  Journal of medicinal chemistry 20061102

• Synthesis and antibacterial activity of the 4-quinolone-3-carboxylic acid derivatives having a trifluoromethyl group as a novel N-1 substituent.

  Journal of medicinal chemistry 20050505