-
Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice.
Pharmacology, biochemistry, and behavior 20121001
-
Bone-targeting glycol and NSAIDS ester prodrugs of rhein: synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies.
European journal of medicinal chemistry 20120901
-
Nutraceuticals in the management of osteoarthritis : a critical review.
Drugs & aging 20120901
-
Diacerein: a potential therapeutic drug for periodontal disease.
Medical hypotheses 20120801
-
[Clinical study of Qianggu granule and diacerein capsule in treating knee osteoarthritis].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120601
-
[Management of osteoarthritis: oral therapies].
La Revue du praticien 20120501
-
Comment on: Ramos-Zavala et al. Effect of diacerein on insulin secretion and metabolic control in drug-naïve patients with type 2 diabetes: a randomized clinical trial. Diabetes Care 2011;34:1591-1594.
Diabetes care 20120201
-
Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee.
International journal of rheumatic diseases 20120201
-
[Clinical efficacy of bushen huoxue qubi decoction on treatment of knee-osteoarthritis and its effect on hemarheology, anti-inflammation and antioxidation].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201
-
A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials.
Current medical research and opinion 20120101
-
Effect of the Japanese herbal medicine, Boiogito, on the osteoarthritis of the knee with joint effusion.
Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT 20120101
-
Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health.
International journal of molecular sciences 20120101
-
Fast-dissolving and high-drug-loaded, Fatty Acid-based self-emulsifying solid dispersions of diacerein.
PDA journal of pharmaceutical science and technology 20120101
-
Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits.
TheScientificWorldJournal 20120101
-
Rhein: a potential biological therapeutic drug for intervertebral disc degeneration.
Medical hypotheses 20111201
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Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet.
Endocrinology 20111101
-
Physicochemical characterization and dissolution study of solid dispersions of diacerein with polyethylene glycol 6000.
Drug development and industrial pharmacy 20111001
-
Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: a randomized clinical trial.
Diabetes care 20110701
-
Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI.
Annals of the rheumatic diseases 20110601
-
Stability-indicating spectrophotometric and spectrodensitometric methods for the determination of diacerein in the presence of its degradation product.
Drug testing and analysis 20110401
-
Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue.
Naunyn-Schmiedeberg's archives of pharmacology 20110301
-
Changes of body weight and inflammatory markers after 12-week intervention trial: results of a double-blind, placebo-control pilot study.
Yonsei medical journal 20110301
-
Lyprinol-is it a useful anti-inflammatory agent?
Evidence-based complementary and alternative medicine : eCAM 20110101
-
Comparison of general practitioners and rheumatologists' prescription patterns for patients with knee osteoarthritis.
BMC musculoskeletal disorders 20110101
-
Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis.
BMC medicine 20110101
-
A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis.
Arthritis research & therapy 20110101
-
T'ai chi for the treatment of osteoarthritis: a systematic review and meta-analysis.
BMJ open 20110101
-
[Pharmacological therapies for osteoarthritis].
Therapie 20110101
-
Development and validation of simultaneous spectrophotometric methods for drotaverine hydrochloride and aceclofenac from tablet dosage form.
Indian journal of pharmaceutical sciences 20110101
-
Improvement in the dissolution profile of diacerein using a surfactant-based solid dispersion technique.
Drug discoveries & therapeutics 20101201
-
Effects of diacerein at the molecular level in the osteoarthritis disease process.
Therapeutic advances in musculoskeletal disease 20100401
-
Diacerein decreases TNF-alpha and IL-1beta levels in peritoneal fluid and prevents Baker's yeast-induced fever in young rats.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100301
-
Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials.
Osteoarthritis and cartilage 20100301
-
Effects of risedronate on osteoarthritis of the knee.
Yonsei medical journal 20100301
-
A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes.
Arthritis research & therapy 20100101
-
Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment.
Arthritis research & therapy 20100101
-
Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment.
Arthritis research & therapy 20100101
-
Small study effects in meta-analyses of osteoarthritis trials: meta-epidemiological study.
BMJ (Clinical research ed.) 20100101
-
Visible spectrophotometric estimation of diacerein in bulk and pharmaceutical dosage forms.
Journal of young pharmacists : JYP 20100101
-
Efficacy and safety of diacerein in early knee osteoarthritis: a randomized placebo-controlled trial.
Clinical rheumatology 20091001
-
Anti-inflammatory and anti-peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation.
Fundamental & clinical pharmacology 20090801
-
Self-reported prevalence of psoriasis and evaluation of the impact on the natural history of hip osteoarthritis: results of a 10 years follow-up study of 507 patients (ECHODIAH study).
Joint, bone, spine : revue du rhumatisme 20090701
-
Physico-chemical and structural characterization of diacerhein.
Journal of pharmaceutical and biomedical analysis 20090501
-
PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition.
Journal of molecular biology 20090424
-
Simultaneous HPLC-UV determination of rhein and aceclofenac in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415
-
Isolation and structural elucidation of two impurities from a diacerein bulk drug.
Journal of pharmaceutical and biomedical analysis 20090220
-
Comment on: comparison between chondroprotective effects of glucosamine, curcumin and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes.
Osteoarthritis and cartilage 20090101
-
[Non-surgical treatment of osteoarthritis of large joints - new aspects].
Wiener medizinische Wochenschrift (1946) 20090101
-
Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis.
Scandinavian journal of rheumatology 20090101
-
The effects of excluding patients from the analysis in randomised controlled trials: meta-epidemiological study.
BMJ (Clinical research ed.) 20090101
-
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.
Arthritis research & therapy 20090101
-
Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial.
International journal of medical sciences 20090101
-
A stability-indicating high performance liquid chromatographic method for the determination of diacerein in capsules.
Indian journal of pharmaceutical sciences 20090101
-
A modified method for isolation of rhein from senna.
Indian journal of pharmaceutical sciences 20090101
-
[Treatment of osteoarthritis with drugs and other modalities].
Der Internist 20081201
-
Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes.
Osteoarthritis and cartilage 20081001
-
Immune system and inflammation.
Indian journal of pharmacology 20081001
-
Prize sessions.
Indian journal of pharmacology 20081001
-
The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?
Pharmacological research 20080701
-
Diacerhein downregulate proinflammatory cytokines expression and decrease the autoimmune diabetes frequency in nonobese diabetic (NOD) mice.
International immunopharmacology 20080601
-
Diacerein has a weak effect on the catabolic pathway of human osteoarthritis synovial fibroblast--comparison to its effects on osteoarthritic chondrocytes.
Rheumatology (Oxford, England) 20080501
-
[Effectiveness of drugs used in degenerative joint diseases (arthroses)].
Medicina clinica 20080405
-
OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines.
Osteoarthritis and cartilage 20080201
-
Intra-articular hyaluronic acid for treatment of osteoarthritis: a nationwide study among the older population of Taiwan.
BMC health services research 20080101
-
The effectiveness of pulsed electrical stimulation (E-PES) in the management of osteoarthritis of the knee: a protocol for a randomised controlled trial.
BMC musculoskeletal disorders 20080101
-
In vitro effects of diacerein on NO production by chondrocytes in response to proinflammatory mediators.
Bio-medical materials and engineering 20080101
-
Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling.
Arthritis research & therapy 20080101
-
Clinical review of chondroitin sulfate in osteoarthritis.
Osteoarthritis and cartilage 20080101
-
Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis.
Arthritis research & therapy 20080101
-
An open prospective study on postmarketing evaluation of the efficacy and tolerability of diacerein in osteo-arthritis of the knee (DOK).
Journal of the Indian Medical Association 20080101
-
Bioequivalence study of two capsule formulations containing diacerein 50 mg in healthy human subjects.
Arzneimittel-Forschung 20080101
-
In vitro inhibition of IL-1beta catabolic effects on cartilage: a mechanism involved on diacerein anti-OA properties.
Biorheology 20080101
-
P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis.
Journal of inflammation (London, England) 20080101
-
Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.
BMC musculoskeletal disorders 20080101
-
The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period.
Arthritis and rheumatism 20071201
-
[Review of the evidence about drugs used as SYSADOA].
Medicina clinica 20071103
-
Nutraceuticals in the management of osteoarthritis.
Orthopedics 20070801
-
The efficacy, safety and carry-over effect of diacerein in the treatment of painful knee osteoarthritis: a randomised, double-blind, NSAID-controlled study.
Osteoarthritis and cartilage 20070601
-
Review: diacerein is more effective than placebo and is as effective as NSAIDs for knee and hip osteoarthritis.
Evidence-based medicine 20070601
-
Selection of reliable reference genes for qPCR studies on chondroprotective action.
BMC molecular biology 20070101
-
DMOAD developments: present and future.
Bulletin of the NYU hospital for joint diseases 20070101
-
A critical appraisal of guidelines for the management of knee osteoarthritis using Appraisal of Guidelines Research and Evaluation criteria.
Arthritis research & therapy 20070101
-
Diacerhein versus glucosamine in a rat model of osteoarthritis.
Clinics (Sao Paulo, Brazil) 20061001
-
A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis.
Archives of internal medicine 20060925
-
Effect of oral diacerein (DAR) in an experimental hip chondrolysis model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20060601
-
Evaluation of efficacy and safety of diacerein in knee osteoarthritis in Chinese patients.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20060601
-
[Inhibitory effect of diacerein on osteoclastic bone destruction and its possible mechanism of action].
Yao xue xue bao = Acta pharmaceutica Sinica 20060601
-
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
-
Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH Cohort.
Annals of the rheumatic diseases 20060301
-
Diacerein for osteoarthritis.
The Cochrane database of systematic reviews 20060125
-
Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow.
Arthritis research & therapy 20060101
-
Inhibition of interleukin-1beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1: potential mechanism for Diacerein effects in osteoarthritis.
Biorheology 20060101
-
IL-1beta synthesis by chondrocyte analyzed by 3D microscopy and flow cytometry: effect of Rhein.
Biorheology 20060101
-
The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice.
Anesthesia and analgesia 20051201
-
Osteoarthritis: an overview of the disease and its treatment strategies.
Seminars in arthritis and rheumatism 20050801
-
[Pharmacological treatment of osteoarthritis. Expectations and reality].
Revista clinica espanola 20050401
-
Future treatment of osteoarthritis.
Orthopedics 20050201
-
Subjective impact of osteoarthritis flare-ups on patients' quality of life.
Health and quality of life outcomes 20050101
-
Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis.
Arthritis research & therapy 20050101
-
Expedient total syntheses of rhein and diacerhein via Fries rearrangement.
The Journal of organic chemistry 20041210
-
Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis.
Annals of the rheumatic diseases 20041201
-
[Total hip arthroplasty indication, evaluation criteria for structure modifying trials. Lessons from the ECHODIAH and PHARE studies].
Presse medicale (Paris, France : 1983) 20040522
-
[Mechanisms of action of diacerein, the first inhibitor of interleukin-1 in osteoarthritis].
Presse medicale (Paris, France : 1983) 20040522
-
Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis.
Osteoarthritis and cartilage 20040401
-
[Chondromodulation in 2003: dream or reality?].
Revue medicale de la Suisse romande 20040201
-
Measurement of structure (disease) modification in osteoarthritis.
Osteoarthritis and cartilage 20040101
-
Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study.
Arthritis research & therapy 20040101
-
Similar group mean scores, but large individual variations, in patient-relevant outcomes over 2 years in meniscectomized subjects with and without radiographic knee osteoarthritis.
Health and quality of life outcomes 20040101
-
Diacerein has a structure/disease-modifying effect on hip osteoarthritis.
Clinical and experimental rheumatology 20040101
-
New perspectives in the management of osteoarthritis. structure modification: facts or fantasy?
The Journal of rheumatology. Supplement 20030801
-
The true results of the ECHODIAH study with diacerein.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20030501
-
Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase.
Clinical and experimental rheumatology 20030101
-
Long-term treatment with diacerein has a structure/disease modifying effect on hip osteoarthritis.
Clinical and experimental rheumatology 20030101
-
[Efficacy of diacerein on the symptoms and radiographic progression of osteoarthritis].
Presse medicale (Paris, France : 1983) 20021207
-
[Comparison of the pharmacologic effect of diacerein and a selective COX-2 inhibitor in the mouse induced-granuloma model].
Presse medicale (Paris, France : 1983) 20021207
-
[Clinical and radiographic status of patients in the ECHODIAH study who underwent THA Pertinence of the pain-function index for operative decision making].
Presse medicale (Paris, France : 1983) 20021207
-
Oral and intra-articular remedies: Review of papers published from March 2001 to February 2002.
Current opinion in rheumatology 20020901
-
Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects.
Matrix biology : journal of the International Society for Matrix Biology 20020801
-
Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption.
European journal of pharmacology 20020712
-
Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha.
Pharmacology & toxicology 20020701
-
[Current therapeutic possibilities in the treatment of arthrosis].
La Revue du praticien 20020301
-
[Current medical possibilities in the treatment of arthrosis].
Presse medicale (Paris, France : 1983) 20020112
-
[Results of the ECHODIAH clinical trial on hip arthrosis].
Presse medicale (Paris, France : 1983) 20020112
-
In vitro study of intracellular IL-1beta production and beta1 integrins expression in stimulated chondrocytes--effect of rhein.
Biorheology 20020101
-
Diacerein as a disease-modulating agent in osteoarthritis.
Current rheumatology reports 20011201
-
Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip.
Arthritis and rheumatism 20011101
-
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.
Immunopharmacology and immunotoxicology 20011101
-
Pharmacological therapy of osteoarthritis.
Best practice & research. Clinical rheumatology 20011001
-
Diacerein suppresses the increase in plasma nitric oxide in rat adjuvant-induced arthritis.
European journal of pharmacology 20010511
-
A novel microassay for the quantitation of the sulfated glycosaminoglycan content of histological sections: its application to determine the effects of Diacerhein on cartilage in an ovine model of osteoarthritis.
Osteoarthritis and cartilage 20010401
-
Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes.
Osteoarthritis and cartilage 20010401
-
Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.
The Journal of rheumatology 20010401
-
The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis.
The Journal of rheumatology 20010401
-
Pharmacologic pain treatment of musculoskeletal disorders: current perspectives and future prospects.
The Clinical journal of pain 20010301
-
Reports of equivalence trials should not mask negative or mediocre results.
Joint, bone, spine : revue du rhumatisme 20010301
-
[Pharmacy clinics. How I treat...Osteoarthritis. 2nd part: new therapeutic perspectives].
Revue medicale de Liege 20010301
-
Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes.
Japanese journal of pharmacology 20010101
-
[Case report of fatal hepatitis from diacerein].
Therapie 20010101
-
Effects of diacerein on indomethacin-induced gastric ulceration.
Pharmacology 20010101
-
Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.
Osteoarthritis and cartilage 20000501
-
Sleep attacks and Parkinson's disease treatment.
Lancet (London, England) 20000415
-
Clinical pharmacokinetics of diacerein.
Clinical pharmacokinetics 19981101
-
Excretion and distribution of [14C]rhein and [14C]rhein anthrone in rat.
The Journal of pharmacy and pharmacology 19880901
