1377049-84-7 | Velpatasvir

Packsize	Purity	Availability	Price	Discounted Price
10mg	95%	in stock	$42.00	$29.00
50mg	95%	in stock	$111.00	$78.00
250mg	95%	in stock	$146.00	$102.00
1g	95%	in stock	$322.00	$225.00
5g	95%	in stock	$889.00	$622.00

Description

• Catalog Number: AB52290
• Chemical Name: Velpatasvir
• CAS Number: 1377049-84-7
• Molecular Formula: C49H54N8O8
• Molecular Weight: 883.0018600000008
• MDL Number: MFCD28411371
• SMILES: COC[C@H]1C[C@H](N(C1)C(=O)[C@@H](c1ccccc1)NC(=O)OC)c1ncc([nH]1)c1ccc2-c3cc4ccc5c(c4cc3OCc2c1)[nH]c(n5)[C@@H]1CC[C@@H](N1C(=O)[C@H](C(C)C)NC(=O)OC)C

Computed Properties

• Complexity: 1690
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 6
• Heavy Atom Count: 65
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 13
• XLogP3: 6.2

Literature

• Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection.

  The New England journal of medicine 20170601

• Preclinical Pharmacokinetics and First-in-Human Pharmacokinetics, Safety, and Tolerability of Velpatasvir, a Pangenotypic Hepatitis C Virus NS5A Inhibitor, in Healthy Subjects.

  Antimicrobial agents and chemotherapy 20170501

• Clinical Resistance to Velpatasvir (GS-5816), a Novel Pan-Genotypic Inhibitor of the Hepatitis C Virus NS5A Protein.

  Antimicrobial agents and chemotherapy 20160901

• A phase 1, randomized, dose-ranging study of GS-5816, a once-daily NS5A inhibitor, in patients with genotype 1-4 hepatitis C virus.

  Journal of viral hepatitis 20151201

• An update on the management of chronic hepatitis C: 2015 Consensus guidelines from the Canadian Association for the Study of the Liver.

  Canadian journal of gastroenterology & hepatology 20150101

• Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.

  Scientific reports 20140101

• Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action.

  Journal of virology 20110701