13794-15-5 | 2-(4-Methoxyphenoxy)propanoic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$28.00	$19.00
5g	98%	in stock	$90.00	$63.00
25g	98%	in stock	$251.00	$176.00
100g	98%	in stock	$713.00	$499.00

Description

• Catalog Number: AA56441
• Chemical Name: 2-(4-Methoxyphenoxy)propanoic acid
• CAS Number: 13794-15-5
• Molecular Formula: C10H12O4
• Molecular Weight: 196.1999
• MDL Number: MFCD01310545
• SMILES: COc1ccc(cc1)OC(C(=O)O)C
• NSC Number: 352144

Computed Properties

• Complexity: 185
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• Undefined Atom Stereocenter Count: 1
• XLogP3: 1.7

Literature

• Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.

  Biochemical and biophysical research communications 20121019

• Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa.

  PloS one 20120101

• Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds.

  PloS one 20120101

• T1R3: a human calcium taste receptor.

  Scientific reports 20120101

• The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells.

  Diabetes & metabolism journal 20111001

• The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY).

  Clinical nutrition (Edinburgh, Scotland) 20110801

• The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.

  American journal of physiology. Endocrinology and metabolism 20110801

• Amino acid taste receptor regulates insulin secretion in pancreatic β-cell line MIN6 cells.

  Genes to cells : devoted to molecular & cellular mechanisms 20110501

• Sensing via intestinal sweet taste pathways.

  Frontiers in neuroscience 20110101

• Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin.

  PloS one 20110101

• Biological Significance of GPCR Heteromerization in the Neuro-Endocrine System.

  Frontiers in endocrinology 20110101

• Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners.

  The British journal of nutrition 20100901

• Amiloride reduces the sweet taste intensity by inhibiting the human sweet taste receptor.

  Biochemical and biophysical research communications 20100625

• Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

  Journal of medicinal chemistry 20091112

• Interactions of the sweet-tasting proteins thaumatin and lysozyme with the human sweet-taste receptor.

  Journal of agricultural and food chemistry 20090708

• The sweet taste quality is linked to a cluster of taste fibers in primates: lactisole diminishes preference and responses to sweet in S fibers (sweet best) chorda tympani fibers of M. fascicularis monkey.

  BMC physiology 20090101

• Genetic and molecular basis of individual differences in human umami taste perception.

  PloS one 20090101

• The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.

  BMC structural biology 20070101

• Neoculin, a taste-modifying protein, is recognized by human sweet taste receptor.

  Neuroreport 20060821

• The G protein-coupled receptor subset of the chicken genome.

  PLoS computational biology 20060601

• The liaison of sweet and savory.

  Chemical senses 20060301

• The heterodimeric sweet taste receptor has multiple potential ligand binding sites.

  Current pharmaceutical design 20060101

• Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3.

  The Journal of biological chemistry 20051007

• Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.

  The Journal of biological chemistry 20050415

• Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor.

  BMC neuroscience 20050101

• Bitter taste receptors for saccharin and acesulfame K.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041110

• Taste enhancements between various amino acids and IMP.

  Chemical senses 20021001