138530-94-6 | (R)-Lansoprazole

Packsize	Purity	Availability	Price	Discounted Price
10mg	95%	in stock	$11.00	$8.00
250mg	95%	in stock	$16.00	$11.00
1g	95%	in stock	$35.00	$25.00
5g	95%	in stock	$163.00	$114.00
25g	95%	in stock	$527.00	$369.00

Description

• Catalog Number: AD54870
• Chemical Name: (R)-Lansoprazole
• CAS Number: 138530-94-6
• Molecular Formula: C16H14F3N3O2S
• Molecular Weight: 369.3615
• MDL Number: MFCD13196699
• SMILES: O=[S@@](c1nc2c([nH]1)cccc2)Cc1nccc(c1C)OCC(F)(F)F

Computed Properties

• Complexity: 480
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 2.8

Literature

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• A randomized, 2-period, crossover design study to assess the effects of dexlansoprazole, lansoprazole, esomeprazole, and omeprazole on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers.

  Journal of the American College of Cardiology 20120403

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• Development and validation of a highly sensitive LC-MS/MS method for quantitation of dexlansoprazole in human plasma: application to a human pharmacokinetic study.

  Biomedical chromatography : BMC 20120201

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  The American journal of gastroenterology 20110301

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• Review article: dual delayed release formulation of dexlansoprazole MR, a novel approach to overcome the limitations of conventional single release proton pump inhibitor therapy.

  Alimentary pharmacology & therapeutics 20090501

• Clinical trial: the effect and timing of food on the pharmacokinetics and pharmacodynamics of dexlansoprazole MR, a novel Dual Delayed Release formulation of a proton pump inhibitor--evidence for dosing flexibility.

  Alimentary pharmacology & therapeutics 20090415

• Clinical trials: healing of erosive oesophagitis with dexlansoprazole MR, a proton pump inhibitor with a novel dual delayed-release formulation--results from two randomized controlled studies.

  Alimentary pharmacology & therapeutics 20090401

• Clinical trial: dexlansoprazole MR, a proton pump inhibitor with dual delayed-release technology, effectively controls symptoms and prevents relapse in patients with healed erosive oesophagitis.

  Alimentary pharmacology & therapeutics 20090401

• Effects of dexlansoprazole MR, a novel dual delayed release formulation of a proton pump inhibitor, on plasma gastrin levels in healthy subjects.

  Journal of clinical pharmacology 20090401

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  The Medical letter on drugs and therapeutics 20090323

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  European journal of clinical pharmacology 20080501

• Influence of ABCB1 C3435T polymorphism on the pharmacokinetics of lansoprazole and gastroesophageal symptoms in Japanese renal transplant recipients classified as CYP2C19 extensive metabolizers and treated with tacrolimus.

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• Intestinal CYP3A4 is not involved in the enantioselective disposition of lansoprazole.

  Xenobiotica; the fate of foreign compounds in biological systems 20060101

• Enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes in the presence of fluvoxamine.

  British journal of clinical pharmacology 20050701

• Effect of clarithromycin on the enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes.

  Chirality 20050601

• Comparison of enantioselective disposition of rabeprazole versus lansoprazole in renal-transplant recipients who are CYP2C19 extensive metabolizers.

  Xenobiotica; the fate of foreign compounds in biological systems 20050501

• Lansoprazole enantiomer activates human liver microsomal CYP2C9 catalytic activity in a stereospecific and substrate-specific manner.

  Drug metabolism and disposition: the biological fate of chemicals 20050201

• Stereoselective inhibition of cytochrome P450 forms by lansoprazole and omeprazole in vitro.

  Xenobiotica; the fate of foreign compounds in biological systems 20050101

• Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes.

  European journal of clinical pharmacology 20041101

• Enantioselective disposition of lansoprazole in extensive and poor metabolizers of CYP2C19.

  Clinical pharmacology and therapeutics 20020701