138977-28-3 | Capsazepine

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$20.00	$14.00
10mg	98%	in stock	$75.00	$52.00
50mg	98%	in stock	$224.00	$157.00
100mg	98%	in stock	$269.00	$188.00

Description

• Catalog Number: AA59376
• Chemical Name: Capsazepine
• CAS Number: 138977-28-3
• Molecular Formula: C19H21ClN2O2S
• Molecular Weight: 376.9002
• MDL Number: MFCD00153778
• SMILES: Clc1ccc(cc1)CCNC(=S)N1CCCc2c(C1)cc(O)c(c2)O

Computed Properties

• Complexity: 445
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: 3.9

Upstream Synthesis Route

Capsazepine, a potent antagonist of the TRPV1 receptor, is a valuable compound in chemical synthesis. Its ability to block the TRPV1 receptor makes it a crucial tool in studies related to pain perception and neurobiology. In chemical synthesis, Capsazepine is frequently utilized as a molecular tool to investigate the role of TRPV1 receptors in various physiological processes. Additionally, it is employed in drug discovery research aimed at developing novel therapeutics for conditions such as chronic pain and inflammation. Capsazepine's unique properties and mechanism of action make it a versatile component in the synthesis of compounds targeted at modulating TRPV1 receptor activity.

Literature

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  Molecular immunology 20130101

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  PloS one 20130101

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  Neuropharmacology 20121201

• Transient receptor potential vanilloid subtype 1 contributes to mesencephalic dopaminergic neuronal survival by inhibiting microglia-originated oxidative stress.

  Brain research bulletin 20121101

• Role of KATP channels and TRPV1 receptors in hydrogen sulfide-enhanced gastric emptying of liquid in awake mice.

  European journal of pharmacology 20121015

• Protection of ghrelin postconditioning on hypoxia/reoxygenation in gastric epithelial cells.

  World journal of gastroenterology 20121014

• Using novel in vitro NociOcular assay based on TRPV1 channel activation for prediction of eye sting potential of baby shampoos.

  Toxicological sciences : an official journal of the Society of Toxicology 20121001

• Acute myocardial infarction inhibits the neurogenic tachycardic and vasopressor response in rats via presynaptic cannabinoid type 1 receptor.

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• A possible participation of transient receptor potential vanilloid type 1 channels in the antidepressant effect of fluoxetine.

  European journal of pharmacology 20120615

• Enhanced vasorelaxant effects of the endocannabinoid-like mediator, oleamide, in hypertension.

  European journal of pharmacology 20120605

• The investigation into indomethacin-induced potentiation of the contractile response to antigen in ovalbumin-sensitized guinea-pig tracheas.

  Fundamental & clinical pharmacology 20120601

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  Epilepsy research 20120601

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  Neuropharmacology 20120601

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• Presynaptic enhancement by eugenol of spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons is mediated by transient receptor potential A1 channels.

  Neuroscience 20120517

• Acid and stretch, but not capsaicin, are effective stimuli for ATP release in the porcine bladder mucosa: Are ASIC and TRPV1 receptors involved?

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• Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice.

  European journal of pharmacology 20120515

• Confocal microscopy with double immunofluorescence staining reveals the functional transient receptor potential vanilloid subtype 1 expressed in myoepithelial cells of human submandibular glands.

  Microscopy research and technique 20120501

• Role of TRPV1 in consolidation of fear memories depends on the averseness of the conditioning procedure.

  Neurobiology of learning and memory 20120501

• Activation of transient receptor potential vanilloid subtype 1 increases expression and permeability of tight junction in normal and hyposecretory submandibular gland.

  Laboratory investigation; a journal of technical methods and pathology 20120501

• Transient receptor potential vanilloid 1 receptors mediate acid-induced mucin secretion via Ca2+ influx in human airway epithelial cells.

  Journal of biochemical and molecular toxicology 20120501

• 20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel.

  The Journal of biological chemistry 20120420

• Vasorelaxation to capsaicin and its effects on calcium influx in arteries.

  European journal of pharmacology 20120415

• Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120401

• Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor.

  Neuropharmacology 20120401

• Gastroprotective potential of frutalin, a D-galactose binding lectin, against ethanol-induced gastric lesions.

  Fitoterapia 20120401

• Cardiac-specific knockout of ET(A) receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction.

  Journal of molecular cell biology 20120401

• Heteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical response.

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• TRPV1 agonist capsaicin attenuates lung ischemia-reperfusion injury in rabbits.

  The Journal of surgical research 20120301

• Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action.

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• [Effects of anandamide on IL-11 production through the TRPV1 of human periodontal ligament cells].

  Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan 20120301

• Influence of influenza A infection on capsaicin-induced responses in murine airways.

  The Journal of pharmacology and experimental therapeutics 20120201

• Transient receptor potential vanilloid-1 participates in the inhibitory effect of ginsenoside Rg1 on capsaicin-induced interleukin-8 and prostaglandin E2 production in HaCaT cells.

  The Journal of pharmacy and pharmacology 20120201

• Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC.

  European journal of pharmacology 20120105

• Beneficial effects of capsiate on ethanol-induced mucosal injury in rats are related to stimulation of calcitonin gene-related Peptide release.

  Planta medica 20120101

• Opposing roles for cannabinoid receptor type-1 (CB₁) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120101

• Thermo-sensitive transient receptor potential vanilloid channel-1 regulates intracellular calcium and triggers chromogranin A secretion in pancreatic neuroendocrine BON-1 tumor cells.

  Cellular signalling 20120101

• Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.

  The Journal of pharmacology and experimental therapeutics 20120101

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  Pain research and treatment 20120101

• Dragon's blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats.

  Journal of pharmacological sciences 20120101

• Activation of TRPV1 by capsaicin induces functional kinin B(1) receptor in rat spinal cord microglia.

  Journal of neuroinflammation 20120101

• L type Ca²+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats.

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• Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines.

  PloS one 20120101

• The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.

  BMC cancer 20120101

• Anandamide induces endothelium-dependent vasoconstriction and CGRPergic nerve-mediated vasodilatation in the rat mesenteric vascular bed.

  Journal of pharmacological sciences 20120101

• Antioncogenic effects of transient receptor potential vanilloid 1 in the progression of transitional urothelial cancer of human bladder.

  ISRN urology 20120101

• Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide.

  ISRN pharmacology 20120101

• The Effectiveness of GECB Pastille in Reducing Complications of Dry Socket Syndrome.

  International journal of dentistry 20120101

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  International journal of medical sciences 20120101

• Antagonism of the TRPv1 receptor partially corrects muscle metaboreflex overactivity in spontaneously hypertensive rats.

  The Journal of physiology 20111215

• Cardiovascular effects of 1-nitro-2-phenylethane, the main constituent of the essential oil of Aniba canelilla, in spontaneously hypertensive rats.

  Fundamental & clinical pharmacology 20111201

• An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects.

  British journal of clinical pharmacology 20111201

• TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release.

  Neuropeptides 20111201

• Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis.

  Cardiovascular research 20111201

• Neurotrophins in the lower urinary tract: becoming of age.

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• Transient receptor potential vanilloid 1 channels modulate the anxiolytic effect of diazepam.

  Brain research 20111124

• The anti-botulism triterpenoid toosendanin elicits calcium increase and exocytosis in rat sensory neurons.

  Cellular and molecular neurobiology 20111101

• Suppression of tumor necrosis factor-α-induced nuclear factor κB activation and aromatase activity by capsaicin and its analog capsazepine.

  Journal of medicinal food 20111101

• Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation.

  Journal of immunology (Baltimore, Md. : 1950) 20111101

• Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.

  Neuroscience 20111013

• Capsaicinoids regulate airway anion transporters through Rho kinase- and cyclic AMP-dependent mechanisms.

  American journal of respiratory cell and molecular biology 20111001

• Opposite effect of capsaicin and capsazepine on behavioral thermoregulation in insects.

  Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20111001

• Contribution of peripheral vanilloid receptor to the nociception induced by injection of spermine in mice.

  Pharmacology, biochemistry, and behavior 20111001

• Characterization of capsaicin induced responses in mice vas deferens: evidence of CGRP uptake.

  European journal of pharmacology 20110930

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  Annals of the rheumatic diseases 20110901

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  European journal of pharmacology 20110901

• Sensitivity of bronchopulmonary receptors to cold and heat mediated by transient receptor potential cation channel subtypes in an ex vivo rat lung preparation.

  Respiratory physiology & neurobiology 20110815

• Cardioprotection by ischemic postconditioning is lost in isolated perfused heart from diabetic rats: Involvement of transient receptor potential vanilloid 1, calcitonin gene-related peptide and substance P.

  Regulatory peptides 20110808

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  Cardiovascular research 20110801

• Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism.

  The Journal of physiology 20110801

• TRPV1 agonist piperine but not olvanil enhances glutamatergic spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons.

  Biochemical and biophysical research communications 20110715

• Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system.

  Pharmacology & therapeutics 20110701

• Desensitization of transient receptor potential ankyrin 1 (TRPA1) by the TRP vanilloid 1-selective cannabinoid arachidonoyl-2 chloroethanolamine.

  Molecular pharmacology 20110701

• Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation.

  Pain 20110701

• Thermosensitive transient receptor potential channels in human corneal epithelial cells.

  Journal of cellular physiology 20110701

• Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats.

  Pancreas 20110701

• Characterization of skin inflammation induced by repeated exposure of toluene, xylene, and formaldehyde in mice.

  Environmental toxicology 20110601

• TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction.

  Journal of cellular physiology 20110601

• TRPV1 receptors modulate retinal development.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20110601

• The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells.

  Cytokine 20110601

• The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro.

  Anesthesiology 20110601

• Lafutidine, a unique histamine H2-receptor antagonist, inhibits distention-induced gastric acid secretion through an H2 receptor-independent mechanism.

  European journal of pharmacology 20110511

• The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110511

• Post-ictal analgesia in genetically epilepsy-prone rats is induced by audiogenic seizures and involves cannabinoid receptors in the periaqueductal gray.

  Brain research 20110510

• Acteoside inhibits PMA-induced matrix metalloproteinase-9 expression via CaMK/ERK- and JNK/NF-κB-dependent signaling.

  Molecular nutrition & food research 20110501

• Disruption of the transient receptor potential vanilloid 1 can affect survival, bacterial clearance, and cytokine gene expression during murine sepsis.

  Anesthesiology 20110501

• Characterization of TRPM8-like channels activated by the cooling agent icilin in the macrophage cell line RAW 264.7.

  The Journal of membrane biology 20110501

• Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia.

  Nature chemical biology 20110501

• TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.

  Nature neuroscience 20110501

• The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors.

  The Journal of physiology 20110501

• Mechanisms underlying the protective effect of eugenol in rats with acute doxorubicin cardiotoxicity.

  Archives of pharmacal research 20110501

• Melittin activates TRPV1 receptors in primary nociceptive sensory neurons via the phospholipase A2 cascade pathways.

  Biochemical and biophysical research communications 20110429

• Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1.

  Neuroscience letters 20110404

• Characterization of in vitro metabolism of capsazepine, a vanilloid transient receptor potential channel antagonist, by liquid chromatography quadrupole ion trap mass spectrometry.

  Biomedical chromatography : BMC 20110401

• Inhibitory effect of standardized cannabis sativa extract and its ingredient cannabidiol on rat and human bladder contractility.

  Urology 20110401

• Increased transient receptor potential vanilloid type 1 (TRPV1) signaling in idiopathic overactive bladder urothelial cells.

  Neurourology and urodynamics 20110401

• Human dental pulp fibroblasts express the 'cold-sensing' transient receptor potential channels TRPA1 and TRPM8.

  Journal of endodontics 20110401

• Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults.

  Neuroscience 20110331

• NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss.

  Antioxidants & redox signaling 20110315

• Atomic force microscopy of microvillous cell surface dynamics at fixed and living alveolar type II cells.

  Analytical and bioanalytical chemistry 20110301

• [Apoptosis inhibition of capsaicin on myocardial ischemia-reperfusion injury in rats].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110301

• Effects of acetazolamide on transient K+ currents and action potentials in nodose ganglion neurons of adult rats.

  CNS neuroscience & therapeutics 20110201

• dsRNA-induced expression of thymic stromal lymphopoietin (TSLP) in asthmatic epithelial cells is inhibited by a small airway relaxant.

  Pulmonary pharmacology & therapeutics 20110201

• Hesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in rats.

  Pharmacology, biochemistry, and behavior 20110201

• Diabetic rats show reduced cardiac-somatic reflex evoked by intrapericardial capsaicin.

  European journal of pharmacology 20110125

• TRPV1 activation is required for hypertonicity-stimulated inflammatory cytokine release in human corneal epithelial cells.

  Investigative ophthalmology & visual science 20110101

• Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats.

  Journal of natural medicines 20110101

• TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation.

  Pain 20110101

• TRPV channel expression in human skin and possible role in thermally induced cell death.

  Journal of burn care & research : official publication of the American Burn Association 20110101

• Capsaicin-induced changes in LTP in the lateral amygdala are mediated by TRPV1.

  PloS one 20110101

• Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B.

  Molecular pain 20110101

• Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components.

  Chinese medicine 20110101

• Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation.

  PloS one 20110101

• Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves.

  PloS one 20110101

• Multimodal assessment of painful peripheral neuropathy induced by chronic oxaliplatin-based chemotherapy in mice.

  Molecular pain 20110101

• Nateglinide stimulates glucagon-like peptide-1 release by human intestinal L cells via a K(ATP) channel-independent mechanism.

  Biological & pharmaceutical bulletin 20110101

• The role of cannabinoids in modulating emotional and non-emotional memory processes in the hippocampus.

  Frontiers in behavioral neuroscience 20110101

• Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors.

  BMC pharmacology 20110101

• Osmosensitivity of transient receptor potential vanilloid 1 is synergistically enhanced by distinct activating stimuli such as temperature and protons.

  PloS one 20110101

• Capsaicin induces reflex scratching in inflamed skin.

  Pharmacology 20110101

• Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB(1) receptors.

  Journal of neuroinflammation 20110101

• Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-κB signaling.

  PloS one 20110101

• Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice.

  PloS one 20110101

• Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects.

  Frontiers in behavioral neuroscience 20110101

• Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.

  PloS one 20110101

• Role of the transient receptor potential vanilloid 1 in inflammation and sepsis.

  Journal of inflammation research 20110101

• NF-κB feedback control of JNK1 activation modulates TRPV1-induced increases in IL-6 and IL-8 release by human corneal epithelial cells.

  Molecular vision 20110101

• Acute myocardial ischemia enhances the vanilloid TRPV1 and serotonin 5-HT3 receptor-mediated Bezold-Jarisch reflex in rats.

  Pharmacological reports : PR 20110101

• Evidence for CGRP re-uptake in rat dura mater encephali.

  British journal of pharmacology 20101201

• The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice.

  Life sciences 20101120

• The protective effect of capsaicin receptor-mediated genistein postconditioning on gastric ischemia-reperfusion injury in rats.

  Digestive diseases and sciences 20101101

• Mechanosensitive transient receptor potential vanilloid type 1 channels contribute to vascular remodeling of rat fistula veins.

  Journal of vascular surgery 20101101

• Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20101101

• Effects of capsazepine, a transient receptor potential vanilloid type 1 antagonist, on morphine-induced antinociception, tolerance, and dependence in mice.

  British journal of anaesthesia 20101101

• Phosphorylation of ERK in the spinal dorsal horn following pancreatic pronociceptive stimuli with proteinase-activated receptor-2 agonists and hydrogen sulfide in rats: evidence for involvement of distinct mechanisms.

  Journal of neuroscience research 20101101

• Transient receptor potential vanilloid type-1 (TRPV-1) channels contribute to cutaneous thermal hyperaemia in humans.

  The Journal of physiology 20101101

• TRPV1 receptors are involved in protein nitration and Müller cell reaction in the acutely axotomized rat retina.

  Experimental eye research 20101101

• Calcitonin gene-related peptide inhibits angiotensin II-induced endothelial progenitor cells senescence through up-regulation of klotho expression.

  Atherosclerosis 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor.

  Journal of neurophysiology 20101101

• Bring on the heat: transient receptor potential vanilloid type-1 (TRPV-1) channels as a sensory link for local thermal hyperaemia.

  The Journal of physiology 20101101

• Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in mice.

  Chemico-biological interactions 20101006

• Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE₂ production in a human keratinocyte cell line HaCaT.

  International immunopharmacology 20101001

• Modulation of single-channel properties of TRPV1 by phosphorylation.

  The Journal of physiology 20101001

• Cardio-respiratory reflexes evoked by phenylbiguanide in rats involve vagal afferents which are not sensitive to capsaicin.

  Acta physiologica (Oxford, England) 20100901

• Existence and distinction of acid-evoked currents in rat astrocytes.

  Glia 20100901

• Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells.

  Experimental eye research 20100901

• Potentiation of the glutamatergic synaptic input to rat locus coeruleus neurons by P2X7 receptors.

  Purinergic signalling 20100901

• Cannabinoid receptors as target for treatment of osteoporosis: a tale of two therapies.

  Current neuropharmacology 20100901

• Axon reflexes evoked by transient receptor potential vanilloid 1 activation are mediated by tetrodotoxin-resistant voltage-gated Na+ channels in intestinal afferent nerves.

  The Journal of pharmacology and experimental therapeutics 20100801

• Role of TRPV1 channels in boar spermatozoa acquisition of fertilizing ability.

  Molecular and cellular endocrinology 20100729

• 1-Nitro-2-phenylethane, the main constituent of the essential oil of Aniba canelilla, elicits a vago-vagal bradycardiac and depressor reflex in normotensive rats.

  European journal of pharmacology 20100725

• Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100711

• Activation of phosphatidylinositol-linked D1-like receptors increases spontaneous glutamate release in rat somatosensory cortical neurons in vitro.

  Brain research 20100709

• Functional vanilloid receptor-1 in human submandibular glands.

  Journal of dental research 20100701

• Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase.

  The Journal of pharmacology and experimental therapeutics 20100701

• The role of capsaicin in spontaneous pacemaking activity in gastrointestinal tract.

  Journal of neurogastroenterology and motility 20100701

• Capsaicin inhibits the spontaneous pacemaker activity in interstitial cells of cajal from the small intestine of mouse.

  Journal of neurogastroenterology and motility 20100701

• 17-Beta-estradiol enhanced allodynia of inflammatory temporomandibular joint through upregulation of hippocampal TRPV1 in ovariectomized rats.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100630

• Role of sensory C fibers in hypoxia/reoxygenation-impaired myogenic constriction of cerebral arteries.

  Neurological research 20100601

• The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice.

  Pharmacological research 20100601

• Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy.

  Experimental neurology 20100601

• Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.

  The Journal of pharmacology and experimental therapeutics 20100601

• Functional roles of TRPV1 channels in lower urinary tract irritated by acetic acid: in vivo evaluations of the sex difference in decerebrate unanesthetized mice.

  American journal of physiology. Renal physiology 20100601

• Nitro-oleic acid inhibits firing and activates TRPV1- and TRPA1-mediated inward currents in dorsal root ganglion neurons from adult male rats.

  The Journal of pharmacology and experimental therapeutics 20100601

• TRPV channels mediate temperature-sensing in human corneal endothelial cells.

  Experimental eye research 20100601

• The nociception induced by glutamate in mice is potentiated by protons released into the solution.

  The journal of pain : official journal of the American Pain Society 20100601

• TRPA1 receptor induced relaxation of the human urethra involves TRPV1 and cannabinoid receptor mediated signals, and cyclooxygenase activation.

  The Journal of urology 20100501

• Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide.

  Journal of hypertension 20100501

• In vitro TRPV1 activity of piperine derived amides.

  Bioorganic & medicinal chemistry 20100501

• Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.

  Nature medicine 20100501

• Opposing effects of cannabinoids and vanilloids on evoked quantal release at the frog neuromuscular junction.

  Neuroscience letters 20100405

• Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet.

  Obesity (Silver Spring, Md.) 20100401

• Neuroprotection induced by vitamin E against oxidative stress in hippocampal neurons: involvement of TRPV1 channels.

  Molecular nutrition & food research 20100401

• The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo.

  Bone 20100401

• Direct activation of transient receptor potential V1 by nickel ions.

  Pflugers Archiv : European journal of physiology 20100401

• The TRPv1 receptor is a mediator of the exercise pressor reflex in rats.

  The Journal of physiology 20100401

• Pharmacological characterization of cannabinoid receptor activity in the rat-isolated ileum myenteric plexus-longitudinal muscle preparation.

  British journal of pharmacology 20100401

• Capsaicin mediates cell death in bladder cancer T24 cells through reactive oxygen species production and mitochondrial depolarization.

  Urology 20100301

• Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway.

  Neurochemistry international 20100301

• Mechanisms of action of hydrogen sulfide in relaxation of mouse distal colonic smooth muscle.

  European journal of pharmacology 20100225

• [The protective mechanism of N-acetylcysteine against ischemia/reperfusion induced gastric injury in rats].

  Sheng li xue bao : [Acta physiologica Sinica] 20100225

• Behavioral assessment and identification of a molecular marker in a salicylate-induced tinnitus in rats.

  Neuroscience 20100217

• Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice.

  Journal of ethnopharmacology 20100217

• Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis.

  Critical care medicine 20100201

• Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay.

  The Journal of pharmacology and experimental therapeutics 20100201

• Glycolic acid induces keratinocyte proliferation in a skin equivalent model via TRPV1 activation.

  Journal of dermatological science 20100201

• Influence of capsicum extract and capsaicin on endothelial health.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20100201

• TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100120

• Protective effect of anacardic acids from cashew (Anacardium occidentale) on ethanol-induced gastric damage in mice.

  Chemico-biological interactions 20100105

• Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles.

  The Journal of physiology 20100101

• 2-APB and capsazepine-induced Ca2+ influx stimulates clathrin-dependent endocytosis in alveolar epithelial cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Antinociceptive effect of geranylgeraniol and 6alpha,7beta-dihydroxyvouacapan-17beta-oate methyl ester isolated from Pterodon pubescens Benth.

  BMC pharmacology 20100101

• Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors.

  PloS one 20100101

• Transient Receptor Potential Vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice.

  Molecular pain 20100101

• Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like growth factor-i in mice and on facial skin elasticity in humans.

  Bioscience, biotechnology, and biochemistry 20100101

• 'TRPing' synaptic ribbon function in the rat pineal gland: neuroendocrine regulation involves the capsaicin receptor TRPV1.

  Neuroendocrinology 20100101

• Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain.

  PloS one 20100101

• Emodin down-regulates expression of TRPV1 mRNA and its function in DRG neurons in vitro.

  The American journal of Chinese medicine 20100101

• Impact of central and peripheral TRPV1 and ROS levels on proinflammatory mediators and nociceptive behavior.

  Molecular pain 20100101

• TRPV1 in brain is involved in acetaminophen-induced antinociception.

  PloS one 20100101

• Moving towards supraspinal TRPV1 receptors for chronic pain relief.

  Molecular pain 20100101

• The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1.

  Journal of pharmacological sciences 20100101

• Involvement of lysophosphatidic acid in bone cancer pain by potentiation of TRPV1 via PKCε pathway in dorsal root ganglion neurons.

  Molecular pain 20100101

• Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain.

  Molecular pain 20100101

• A non-anesthetized mouse model for recording sensory urinary bladder activity.

  Frontiers in neurology 20100101

• Effect of resiniferatoxin on glutamatergic spontaneous excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.

  Neuroscience 20091229

• Characterization of an AM404 analogue, N-(3-hydroxyphenyl)arachidonoylamide, as a substrate and inactivator of prostaglandin endoperoxide synthase.

  Biochemistry 20091229

• Up-regulation of CYP1A1 by rutaecarpine is dependent on aryl hydrocarbon receptor and calcium.

  Toxicology 20091221

• Sex differences in the expression profile of acid-sensing ion channels in the mouse urinary bladder: a possible involvement in irritative bladder symptoms.

  BJU international 20091201

• Anionic linear aliphatic surfactants activate TRPV1: a possible endpoint for estimation of detergent induced eye nociception?

  Toxicology in vitro : an international journal published in association with BIBRA 20091201

• Release of ATP from rat urinary bladder mucosa: role of acid, vanilloids and stretch.

  British journal of pharmacology 20091201

• The cannabinoid R+ methanandamide induces IL-6 secretion by prostate cancer PC3 cells.

  Journal of immunotoxicology 20091201

• Effects of transient receptor potential (TRP) channel agonists and antagonists on slowly adapting type II mechanoreceptors in the rat sinus hair follicle.

  Journal of the peripheral nervous system : JPNS 20091201

• Characterization of a calcitonin gene-related peptide release assay in rat isolated distal colon.

  Archives of pharmacal research 20091201

• Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation.

  Journal of neuroimmunology 20091130

• Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.

  FEBS letters 20091119

• Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids.

  Progress in neuro-psychopharmacology & biological psychiatry 20091113

• Non-selective cation channel activity is required for lysophosphatidylcholine-induced monocyte migration.

  Journal of cellular physiology 20091101

• Capsaicin protects mouse neuromuscular junctions from the neuroparalytic effects of botulinum neurotoxin a.

  The Journal of pharmacology and experimental therapeutics 20091101

• Endogenous expression of TRPV1 channel in cultured human melanocytes.

  Journal of dermatological science 20091101

• Do distinct populations of dorsal root ganglion neurons account for the sensory peptidergic innervation of the kidney?

  American journal of physiology. Renal physiology 20091101

• Electrophysiological and morphological properties of neurons in the substantia gelatinosa of the mouse trigeminal subnucleus caudalis.

  Pain 20091101

• Acid-evoked Ca2+ signalling in rat sensory neurones: effects of anoxia and aglycaemia.

  Pflugers Archiv : European journal of physiology 20091101

• Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents.

  British journal of pharmacology 20091101

• Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate.

  Brain research 20091027

• Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde.

  Sheng li xue bao : [Acta physiologica Sinica] 20091025

• Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20091001

• Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability.

  Endocrinology 20091001

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice.

  British journal of pharmacology 20091001

• Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery.

  The Journal of pharmacology and experimental therapeutics 20090901

• Hydrogen sulfide prevents ethanol-induced gastric damage in mice: role of ATP-sensitive potassium channels and capsaicin-sensitive primary afferent neurons.

  The Journal of pharmacology and experimental therapeutics 20090901

• Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.

  The Journal of pharmacology and experimental therapeutics 20090901

• AT(1) receptor blockers increase insulin-like growth factor-I production by stimulating sensory neurons in spontaneously hypertensive rats.

  Translational research : the journal of laboratory and clinical medicine 20090901

• Possible role for TRPV1 in neomycin-induced inhibition of visceral hypersensitivity in rat.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090801

• Anxiolytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the medial prefrontal cortex of rats.

  Psychopharmacology 20090801

• Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia.

  Pain 20090801

• Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.

  Carcinogenesis 20090801

• N-arachidonyl dopamine sensitizes rat capsaicin-sensitive lung vagal afferents via activation of TRPV1 receptors.

  Respiratory physiology & neurobiology 20090731

• Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice.

  Neuroscience letters 20090717

• Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium.

  The Journal of physiology 20090715

• Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats.

  Neuroscience letters 20090703

• (Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20090701

• QX-314 produces long-lasting local anesthesia modulated by transient receptor potential vanilloid receptors in mice.

  Anesthesiology 20090701

• Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults.

  Environmental health perspectives 20090701

• Ethanol aggravates itch-related scratching in hairless mice developing atopic dermatitis.

  European journal of pharmacology 20090602

• A novel role for the TRPV1 channel in UV-induced matrix metalloproteinase (MMP)-1 expression in HaCaT cells.

  Journal of cellular physiology 20090601

• Bronchoconstriction induced by hyperventilation with humidified hot air: role of TRPV1-expressing airway afferents.

  Journal of applied physiology (Bethesda, Md. : 1985) 20090601

• Depolarization-induced release of endocannabinoids by murine dorsal motor nucleus of the vagus nerve neurons differentially regulates inhibitory and excitatory neurotransmission.

  Neuropharmacology 20090601

• Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone.

  American journal of physiology. Heart and circulatory physiology 20090601

• Enhancement of the hypotensive effects of intrathecally injected endocannabinoids by the entourage compound palmitoylethanolamide.

  European journal of pharmacology 20090521

• A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090513

• Transient receptor potential vanilloid type 1 receptor regulates glutamatergic synaptic inputs to the spinothalamic tract neurons of the spinal cord deep dorsal horn.

  Neuroscience 20090505

• Excitation of cutaneous C nociceptors by intraplantar administration of anandamide.

  Brain research 20090501

• Anandamide-induced behavioral disruption through a vanilloid-dependent mechanism in rats.

  Psychopharmacology 20090401

• Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: role of transient receptor potential vanilloid 1 receptors.

  Journal of applied physiology (Bethesda, Md. : 1985) 20090401

• Functional TRP and ASIC-like channels in cultured urothelial cells from the rat.

  American journal of physiology. Renal physiology 20090401

• Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries.

  European journal of pharmacology 20090401

• Functional type I vanilloid receptor expression by substantia gelatinosa neurons of trigeminal subnucleus caudalis in mice.

  Neuroscience letters 20090320

• Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus.

  European journal of pharmacology 20090315

• Modulation of anxiety-like behaviour by Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090301

• N-acyldopamines control striatal input terminals via novel ligand-gated cation channels.

  Neuropharmacology 20090301

• Functional characterization of nonadrenergic noncholinergic neurotransmitter release via endocannabinoids: an in vitro study in rabbit corpus cavernosum.

  The journal of sexual medicine 20090301

• Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanol.

  Neuropharmacology 20090301

• Nociceptive vascular reflexes evoked by scorpion venom modulate cardiorespiratory parameters involving vanilloid receptor 1 in anaesthetised rats.

  Neuroscience letters 20090227

• TRPA1 activation by lidocaine in nerve terminals results in glutamate release increase.

  Biochemical and biophysical research communications 20090220

• Excitatory and inhibitory urinary bladder reflexes induced by stimulation of cervicovaginal capsaicin-sensitive sensory fibers in rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20090201

• Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat.

  Gut 20090201

• Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication.

  Hypertension (Dallas, Tex. : 1979) 20090201

• Activation of sensory neurons reduces ischemia/reperfusion-induced acute renal injury in rats.

  Anesthesiology 20090201

• Capsaicin-induced glutamate release is implicated in nociceptive processing through activation of ionotropic glutamate receptors and group I metabotropic glutamate receptor in primary afferent fibers.

  Journal of pharmacological sciences 20090201

• Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor.

  PLoS biology 20090201

• Differential effects of topically applied formalin and aromatic compounds on neurogenic-mediated microvascular leakage in rat skin.

  Toxicology 20090108

• Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells.

  FEBS letters 20090105

• TRPV1 channels facilitate glutamate transmission in the striatum.

  Molecular and cellular neurosciences 20090101

• Divergent effects of anandamide transporter inhibitors with different target selectivity on social play behavior in adolescent rats.

  The Journal of pharmacology and experimental therapeutics 20090101

• Contribution of transient receptor potential vanilloid subtype 1 to the analgesic and antihyperalgesic activity of nefopam in rodents.

  Pharmacology 20090101

• Antiaversive effects of cannabinoids: is the periaqueductal gray involved?

  Neural plasticity 20090101

• Vanilloid receptor antagonists: emerging class of novel anti-inflammatory agents for pain management.

  Current pharmaceutical design 20090101

• Reactive oxygen species mediate TNFR1 increase after TRPV1 activation in mouse DRG neurons.

  Molecular pain 20090101

• TRPM8, a versatile channel in human sperm.

  PloS one 20090101

• Tumor necrosis factor-alpha (TNF-alpha) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes.

  Molecular pain 20090101

• Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia.

  PloS one 20090101

• NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity.

  Molecular pain 20090101

• Dynamic regulation of the endocannabinoid system: implications for analgesia.

  Molecular pain 20090101

• Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.

  Molecular pain 20090101

• Polymorphisms in gene encoding TRPV1-receptor involved in pain perception are unrelated to chronic pancreatitis.

  BMC gastroenterology 20090101

• [Modulation of the smooth muscle contractions of the rat vas deferens by TRPM8 channel agonist menthol].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20090101

• TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons.

  Biochemical and biophysical research communications 20081226

• Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20081203

• CO2 chemosensing in rat oesophagus.

  Gut 20081201

• Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20081201

• Virodhamine relaxes the human pulmonary artery through the endothelial cannabinoid receptor and indirectly through a COX product.

  British journal of pharmacology 20081201

• Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons.

  Neuropharmacology 20081201

• Rutaecarpine inhibits hypoxia/reoxygenation-induced apoptosis in rat hippocampal neurons.

  Neuropharmacology 20081201

• Cannabinoids and capsaicin improve liver function following thioacetamide-induced acute injury in mice.

  The American journal of gastroenterology 20081201

• Extracellular signal-regulated kinases mediate melittin-induced hypersensitivity of spinal neurons to chemical and thermal but not mechanical stimuli.

  Brain research bulletin 20081125

• TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats.

  American journal of physiology. Renal physiology 20081101

• Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia.

  European journal of pharmacology 20081031

• Transient receptor potential vanilloid 1-mediated expression and secretion of endothelial cell-derived calcitonin gene-related peptide.

  Regulatory peptides 20081009

• Dependence of regulatory volume decrease on transient receptor potential vanilloid 4 (TRPV4) expression in human corneal epithelial cells.

  Cell calcium 20081001

• Heat-induced MMP-1 expression is mediated by TRPV1 through PKCalpha signaling in HaCaT cells.

  Experimental dermatology 20081001

• Behavioral and electrophysiological evidence for the differential functions of TRPV1 at early and late stages of chronic inflammatory nociception in rats.

  Neurochemical research 20081001

• Calcitonin gene-related peptide-mediated antihypertensive and anti-platelet effects by rutaecarpine in spontaneously hypertensive rats.

  Peptides 20081001

• Transient receptor potential vanilloid subtype 1 channel mediated neuropeptide secretion and depressor effects: role of endoplasmic reticulum associated Ca2+ release receptors in rat dorsal root ganglion neurons.

  Journal of hypertension 20081001

• A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan.

  PLoS genetics 20081001

• Capsaicin inhibits the in vitro binding of peptides selective for mu- and kappa-opioid, and nociceptin-receptors.

  Brain research bulletin 20080930

• Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1.

  Journal of neurophysiology 20080901

• Estrous cycle variation of TRPV1-mediated cross-organ sensitization between uterus and NMDA-dependent pelvic-urethra reflex activity.

  American journal of physiology. Endocrinology and metabolism 20080901

• Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080901

• Antistress effect of TRPV1 channel on synaptic plasticity and spatial memory.

  Biological psychiatry 20080815

• A subpopulation of capsaicin-sensitive porcine dorsal root ganglion neurons is lacking hyperpolarization-activated cyclic nucleotide-gated channels.

  European journal of pain (London, England) 20080801

• Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans.

  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20080801

• Role of TRPV1 channels in renal haemodynamics and function in Dahl salt-sensitive hypertensive rats.

  Experimental physiology 20080801

• Involvement of TRPV1 in nociceptive behavior in a rat model of cancer pain.

  The journal of pain : official journal of the American Pain Society 20080801

• Dual effect of anandamide on rat placenta nitric oxide synthesis.

  Placenta 20080801

• SA13353 (1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea) inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons mediated via transient receptor potential vanilloid 1 in vivo.

  European journal of pharmacology 20080707

• Sustained increase of Ca+2 oscillations after chronic TRPV1 receptor activation with capsaicin in cultured spinal neurons.

  Brain research 20080707

• Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress: role of endogenous prostacyclin and sensory nerves.

  The Journal of pharmacology and experimental therapeutics 20080701

• In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI.

  British journal of pharmacology 20080701

• Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.

  The Journal of clinical investigation 20080701

• Gastroprotective mechanisms of centipedic acid, a natural diterpene from Egletes viscosa LESS.

  Biological & pharmaceutical bulletin 20080701

• Attenuation of anxiety-related behaviour after the antagonism of transient receptor potential vanilloid type 1 channels in the rat ventral hippocampus.

  Behavioural pharmacology 20080701

• [Protective effect of capsaicin on against myocardial ischemia-reperfusion injury of rat in vivo].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080701

• Gastroprotective action of orexin-A against stress-induced gastric damage is mediated by endogenous prostaglandins, sensory afferent neuropeptides and nitric oxide.

  Regulatory peptides 20080605

• The activation of transient receptor potential vanilloid receptor subtype 1 by capsaicin without extracellular Ca2+ is involved in the mechanism of distinct substance P release in cultured rat dorsal root ganglion neurons.

  Naunyn-Schmiedeberg's archives of pharmacology 20080601

• Interdependent regulation of afferent renal nerve activity and renal function: role of transient receptor potential vanilloid type 1, neurokinin 1, and calcitonin gene-related peptide receptors.

  The Journal of pharmacology and experimental therapeutics 20080601

• Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome.

  American journal of physiology. Heart and circulatory physiology 20080601

• Monoacylglycerols activate capsaicin receptor, TRPV1.

  Lipids 20080601

• The analgesic drug, tramadol, acts as an agonist of the transient receptor potential vanilloid-1.

  Anesthesia and analgesia 20080601

• Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat.

  The European journal of neuroscience 20080601

• Functional expression of transient receptor potential vanilloid-related channels in chronically hypoxic human pulmonary arterial smooth muscle cells.

  The Journal of membrane biology 20080601

• TRPV1: a target for next generation analgesics.

  Current neuropharmacology 20080601

• TRPV1 mediates cell death in rat synovial fibroblasts through calcium entry-dependent ROS production and mitochondrial depolarization.

  Biochemical and biophysical research communications 20080516

• Quebrachitol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide and K+ ATP channels.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20080501

• The TRPV1 receptor is associated with preferential stress in large dorsal root ganglion neurons in early diabetic sensory neuropathy.

  Journal of neurochemistry 20080501

• Functional study on TRPV1-mediated signalling in the mouse small intestine: involvement of tachykinin receptors.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080501

• TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080501

• Segmental regulation of sodium and water excretion by TRPV1 activation in the kidney.

  Journal of cardiovascular pharmacology 20080501

• A saturated N-acylethanolamine other than N-palmitoyl ethanolamine with anti-inflammatory properties: a neglected story..

  Journal of neuroendocrinology 20080501

• Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1.

  The Journal of biological chemistry 20080404

• Cardiac oxidative stress and electrophysiological changes in rats exposed to concentrated ambient particles are mediated by TRP-dependent pulmonary reflexes.

  Toxicological sciences : an official journal of the Society of Toxicology 20080401

• Pronociceptive response elicited by TRPA1 receptor activation in mice.

  Neuroscience 20080318

• SAR studies of capsazepinoid bronchodilators. Part 2: Chlorination and catechol replacement in the A-ring.

  Bioorganic & medicinal chemistry 20080301

• SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure.

  Bioorganic & medicinal chemistry 20080301

• Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons.

  American journal of physiology. Lung cellular and molecular physiology 20080301

• SAR studies of capsazepinoid bronchodilators 3: The thiourea part (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region).

  Bioorganic & medicinal chemistry 20080301

• Gastroprotective effect of a flavone from Lonchocarpus araripensis Benth. (Leguminosae) and the possible mechanism.

  The Journal of pharmacy and pharmacology 20080301

• Increased GFR and renal excretory function by activation of TRPV1 in the isolated perfused kidney.

  Pharmacological research 20080301

• Lafutidine facilitates calcitonin gene-related peptide (CGRP) nerve-mediated vasodilation via vanilloid-1 receptors in rat mesenteric resistance arteries.

  Journal of pharmacological sciences 20080301

• ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1.

  Current neuropharmacology 20080301

• Herbal compounds and toxins modulating TRP channels.

  Current neuropharmacology 20080301

• The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level.

  Pain 20080201

• Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats.

  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20080201

• Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys.

  American journal of physiology. Renal physiology 20080201

• The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons.

  The Journal of clinical investigation 20080201

• Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis.

  PLoS biology 20080201

• Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETE-induced scratching in mice.

  European journal of pharmacology 20080128

• Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel.

  Biochemical pharmacology 20080115

• Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues.

  Journal of medicinal chemistry 20080110

• Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.

  Journal of the National Cancer Institute 20080102

• Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95.

  Pulmonary pharmacology & therapeutics 20080101

• Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice.

  Neurochemistry international 20080101

• Ethanol causes neurogenic vasodilation by TRPV1 activation and CGRP release in the trigeminovascular system of the guinea pig.

  Cephalalgia : an international journal of headache 20080101

• TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.

  American journal of physiology. Gastrointestinal and liver physiology 20080101

• Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia.

  Molecular pain 20080101

• Molecular and cellular limits to somatosensory specificity.

  Molecular pain 20080101

• PPARgamma and Apoptosis in Cancer.

  PPAR research 20080101

• Histamine-induced itch and its relationship with pain.

  Molecular pain 20080101

• Direct activation of transient receptor potential vanilloid 1(TRPV1) by diacylglycerol (DAG).

  Molecular pain 20080101

• Differential stimulatory effects of cannabinoids on VIP release and NO synthase activity in synaptosomal fractions from rat ileum.

  Neuropeptides 20080101

• Human keratinocytes are vanilloid resistant.

  PloS one 20080101

• Mechanisms involved in an increment of multimodal excitability of medullary and upper cervical dorsal horn neurons following cutaneous capsaicin treatment.

  Molecular pain 20080101

• TRPM8 mechanism of cold allodynia after chronic nerve injury.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20071212

• Transient receptor potential vanilloid 1 activation induces inflammatory cytokine release in corneal epithelium through MAPK signaling.

  Journal of cellular physiology 20071201

• Anandamide improves the impaired nitric oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats: involvement of cannabinoid CB1 and vanilloid VR1 receptors.

  BJU international 20071201

• Neuroprotective effects of glyceryl nonivamide against microglia-like cells and 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y human dopaminergic neuroblastoma cells.

  The Journal of pharmacology and experimental therapeutics 20071201

• Voltage is a partial activator of rat thermosensitive TRP channels.

  The Journal of physiology 20071201

• Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors.

  British journal of pharmacology 20071201

• Increased depressor response to N-arachidonoyl-dopamine during high salt intake: role of the TRPV1 receptor.

  Journal of hypertension 20071201

• Cannabinoids in health and disease.

  Dialogues in clinical neuroscience 20071201

• Involvement of peripheral TRPV1 in TMJ hyperalgesia induced by ethanol withdrawal.

  Life sciences 20071130

• Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.

  British journal of pharmacology 20071101

• Involvement of a capsaicin-sensitive TRPV1-independent mechanism in lipopolysaccharide-induced fever in chickens.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20071101

• Delta 9-tetrahydrocannabinol inhibits electrically-evoked CGRP release and capsaicin-sensitive sensory neurogenic vasodilatation in the rat mesenteric arterial bed.

  British journal of pharmacology 20071101

• Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors.

  Experimental neurology 20071101

• Transient receptor potential vanilloid-1 mediates heat-shock-induced matrix metalloproteinase-1 expression in human epidermal keratinocytes.

  The Journal of investigative dermatology 20071001

• Capsaicin-induced avoidance behavior in the terrestrial Gastropoda Megalobulimus abbreviatus: evidence for TRPV-1 signaling and opioid modulation in response to chemical noxious stimuli.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20071001

• Fatty acyl amides of endogenous tetrahydroisoquinolines are active at the recombinant human TRPV1 receptor.

  Bioorganic & medicinal chemistry 20070915

• Acid-induced modulation of airway basal tone and contractility: role of acid-sensing ion channels (ASICs) and TRPV1 receptor.

  Life sciences 20070908

• 12-Lipoxygenase-derived eicosanoids protect against myocardial ischemia/reperfusion injury via activation of neuronal TRPV1.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070901

• Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation?

  Toxicological sciences : an official journal of the Society of Toxicology 20070901

• TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice.

  American journal of physiology. Heart and circulatory physiology 20070901

• Bladder afferent sensitivity in wild-type and TRPV1 knockout mice.

  The Journal of physiology 20070901

• Eugenol inhibits K+ currents in trigeminal ganglion neurons.

  Journal of dental research 20070901

• Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons.

  The European journal of neuroscience 20070901

• A pharmacological study of slowly adapting mechanoreceptors responsive to cold thermal stimulation.

  Neuroscience 20070824

• 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.

  Proceedings of the National Academy of Sciences of the United States of America 20070814

• Role of capsaicin-sensitive sensory nerves in protease-activated receptor-2-mediated contraction of rat urinary bladder.

  European journal of pharmacology 20070813

• Expression of transient receptor potential vanilloid 1 (TRPV1) in synovial fibroblasts from patients with osteoarthritis and rheumatoid arthritis.

  Biochemical and biophysical research communications 20070810

• Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation.

  Journal of neurochemistry 20070801

• Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2+)](i), initiates neurotransmitter release and promotes delayed cell death.

  Journal of neurochemistry 20070801

• Bradykinin-induced nuclear factor of activated T-cells-dependent transcription in rat dorsal root ganglion neurons.

  Molecular pharmacology 20070801

• Atrial natriuretic peptide reduces ischemia/reperfusion-induced spinal cord injury in rats by enhancing sensory neuron activation.

  The Journal of pharmacology and experimental therapeutics 20070801

• Effects of anandamide and noxious heat on intracellular calcium concentration in nociceptive drg neurons of rats.

  Journal of neurophysiology 20070801

• A potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20070801

• Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors.

  The European journal of neuroscience 20070801

• A novel function of capsaicin-sensitive TRPV1 channels: involvement in cell migration.

  Cell calcium 20070701

• The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.

  Neuropharmacology 20070701

• Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats.

  Investigative ophthalmology & visual science 20070701

• Preserving cardiac output with beta-adrenergic receptor blockade and inhibiting the Bezold-Jarisch reflex during resuscitation from hemorrhage.

  The Journal of trauma 20070701

• The anandamide transport inhibitor AM404 reduces ethanol self-administration.

  The European journal of neuroscience 20070701

• AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain.

  Brain research 20070604

• Transient receptor potential vanilloid 1 antagonist, capsazepine, improves survival in a rat hemorrhagic shock model.

  Annals of surgery 20070601

• The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.

  Journal of medicinal chemistry 20070531

• Novel agonistic action of mustard oil on recombinant and endogenous porcine transient receptor potential V1 (pTRPV1) channels.

  Biochemical pharmacology 20070515

• Mouse colon sensory neurons detect extracellular acidosis via TRPV1.

  American journal of physiology. Cell physiology 20070501

• Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet.

  The Journal of pharmacology and experimental therapeutics 20070501

• Antinociceptive pharmacology of N-(4-chlorobenzyl)-N'-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea, a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor.

  The Journal of pharmacology and experimental therapeutics 20070501

• Cannabinoid and vanilloid effects of R(+)-methanandamide in the hemisected meningeal preparation.

  Cephalalgia : an international journal of headache 20070501

• Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070418

• Capsicum ethanol extracts and capsaicin enhance interleukin-2 and interferon-gamma production in cultured murine Peyer's patch cells ex vivo.

  Life sciences 20070403

• Capsaicin induces the production of IL-6 in human upper respiratory epithelial cells.

  Life sciences 20070403

• Involvement of endothelial cell-derived CGRP in heat stress-induced protection of endothelial function.

  Vascular pharmacology 20070401

• The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport.

  The Journal of pharmacology and experimental therapeutics 20070401

• Heat sensitization in skin and muscle nociceptors expressing distinct combinations of TRPV1 and TRPV2 protein.

  Journal of neurophysiology 20070401

• Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging.

  British journal of pharmacology 20070401

• The preventive effect of Daikenchuto on postoperative adhesion-induced intestinal obstruction in rats.

  Inflammopharmacology 20070401

• Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint.

  Life sciences 20070327

• Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death.

  Biochemical and biophysical research communications 20070302

• Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.

  British journal of pharmacology 20070301

• Pharmacological characterisation of capsaicin-induced relaxations in human and porcine isolated arteries.

  Naunyn-Schmiedeberg's archives of pharmacology 20070301

• TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070227

• The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.

  European journal of pharmacology 20070205

• Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats.

  Digestive diseases and sciences 20070201

• Vanilloid (subtype 1) receptor-modulatory drugs inhibit [3H]batrachotoxinin-A 20-alpha-benzoate binding to Na+ channels.

  Basic & clinical pharmacology & toxicology 20070201

• TRPV1 is a novel target for omega-3 polyunsaturated fatty acids.

  The Journal of physiology 20070115

• Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants.

  Pulmonary pharmacology & therapeutics 20070101

• Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons.

  The Journal of pharmacology and experimental therapeutics 20070101

• Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin.

  Bioorganic & medicinal chemistry letters 20070101

• Danaparoid sodium reduces ischemia/reperfusion-induced liver injury in rats by attenuating inflammatory responses.

  Thrombosis and haemostasis 20070101

• Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig.

  Pulmonary pharmacology & therapeutics 20070101

• TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model: a study with piperine, a new TRPV1 agonist.

  Neurourology and urodynamics 20070101

• Transient receptor potential ion channels control thermoregulatory behaviour in reptiles.

  PloS one 20070101

• Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel.

  PloS one 20070101

• TRPV1-mediated diuresis and natriuresis induced by hypertonic saline perfusion of the renal pelvis.

  American journal of nephrology 20070101

• Novel technique for estimating cerebrovascular permeability demonstrates capsazepine protection following ischemia-reperfusion.

  Microcirculation (New York, N.Y. : 1994) 20070101

• Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin.

  Molecular pain 20070101

• Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists.

  Molecular pain 20070101

• Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig.

  Cough (London, England) 20070101

• Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.

  British journal of pharmacology 20061201

• Impaired vasodilation in response to perivascular nerve stimulation in mesenteric arteries of TRPV1-null mutant mice.

  Journal of hypertension 20061201

• Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?

  European journal of pharmacology 20061121

• Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice.

  American journal of physiology. Lung cellular and molecular physiology 20061101

• TRPV1 receptors and nasal trigeminal chemesthesis.

  Chemical senses 20061101

• Capsaicin inhibits catecholamine secretion and synthesis by blocking Na+ and Ca2+ influx through a vanilloid receptor-independent pathway in bovine adrenal medullary cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20061101

• Differential mechanisms mediating depressor and diuretic effects of anandamide.

  Journal of hypertension 20061101

• Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon.

  Gastroenterology 20061101

• Characterization of the vasorelaxation to methanandamide in rat gastric arteries.

  Canadian journal of physiology and pharmacology 20061101

• Transient receptor potential vanilloid subtype 1 mediates microglial cell death in vivo and in vitro via Ca2+-mediated mitochondrial damage and cytochrome c release.

  Journal of immunology (Baltimore, Md. : 1950) 20061001

• Eugenol inhibits sodium currents in dental afferent neurons.

  Journal of dental research 20061001

• Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060901

• A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats.

  Neuropharmacology 20060901

• Effect of anandamide on nonadrenergic noncholinergic-mediated relaxation of rat corpus cavernosum.

  European journal of pharmacology 20060821

• Effect of capsazepine on cytosolic Ca(2+) levels and proliferation of human prostate cancer cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20060801

• Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs.

  Journal of applied physiology (Bethesda, Md. : 1985) 20060801

• Mediator mechanisms involved in TRPV1 and P2X receptor-mediated, ROS-evoked bradypneic reflex in anesthetized rats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20060801

• Effect of intracochlear perfusion of vanilloids on cochlear neural activity in the guinea pig.

  Hearing research 20060801

• Characterization of acid signaling in rat vagal pulmonary sensory neurons.

  American journal of physiology. Lung cellular and molecular physiology 20060701

• Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats.

  Journal of neurochemistry 20060701

• Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum.

  Gastroenterology 20060701

• Expression and characteristics of vanilloid receptor 1 in the rabbit submandibular gland.

  Biochemical and biophysical research communications 20060623

• Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide].

  The Journal of pharmacology and experimental therapeutics 20060601

• Ethanol dilates coronary arteries and increases coronary flow via transient receptor potential vanilloid 1 and calcitonin gene-related peptide.

  Cardiovascular research 20060601

• Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats.

  Thrombosis and haemostasis 20060601

• Tactile allodynia initiated by local subcutaneous endothelin-1 is prolonged by activation of TRPV-1 receptors.

  Experimental biology and medicine (Maywood, N.J.) 20060601

• Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins.

  World journal of gastroenterology 20060521

• Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis.

  American journal of physiology. Gastrointestinal and liver physiology 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Caged vanilloid ligands for activation of TRPV1 receptors by 1- and 2-photon excitation.

  Biochemistry 20060418

• Pharmacological characterisation of the plant sesquiterpenes polygodial and drimanial as vanilloid receptor agonists.

  Biochemical pharmacology 20060414

• Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060401

• Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells.

  Neuropharmacology 20060401

• Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices.

  Synapse (New York, N.Y.) 20060401

• Participation of the spinal TRPV1 receptors in formalin-evoked pain transduction: a study using a selective TRPV1 antagonist, iodo-resiniferatoxin.

  The Journal of pharmacy and pharmacology 20060401

• Role of TRPV1 and cannabinoid CB1 receptors in AM 404-evoked hypothermia in rats.

  Pharmacology, biochemistry, and behavior 20060401

• Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implications.

  Biological psychiatry 20060315

• A novel mechanism contributing to development of Dahl salt-sensitive hypertension: role of the transient receptor potential vanilloid type 1.

  Hypertension (Dallas, Tex. : 1979) 20060301

• Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection.

  British journal of pharmacology 20060301

• Role of capsaicin-sensitive sensory nerves in mediation of the cardiovascular effects of the essential oil of croton zehntneri leaves in anaesthetized rats.

  Clinical and experimental pharmacology & physiology 20060301

• Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila.

  European journal of pharmacology 20060217

• Vanilloid type 1 receptor and the acid-sensing ion channel mediate acid phosphate activation of muscle afferent nerves in rats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20060201

• Pain behaviors produced by capsaicin: influence of inflammatory mediators and nerve injury.

  The journal of pain : official journal of the American Pain Society 20060201

• Methanandamide hyperpolarizes gastric arteries by stimulation of TRPV1 receptors on perivascular CGRP containing nerves.

  Journal of cardiovascular pharmacology 20060201

• Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain.

  Journal of medicinal chemistry 20060126

• Analgesic effects of capsazepine and resiniferatoxin on bone cancer pain in mice.

  Neuroscience letters 20060123

• Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum.

  European journal of pharmacology 20060113

• Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum.

  European journal of pharmacology 20060113

• Attenuation of acid induced oesophagitis in VR-1 deficient mice.

  Gut 20060101

• TRPV1 antagonists elevate cell surface populations of receptor protein and exacerbate TRPV1-mediated toxicities in human lung epithelial cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20060101

• Activity and expression of the vanilloid receptor 1 (TRPV1) is altered by long-term diabetes in epineurial arterioles of the rat sciatic nerve.

  Diabetes/metabolism research and reviews 20060101

• Facilitation and inhibition by capsaicin of cholinergic neurotransmission in the guinea-pig small intestine.

  Naunyn-Schmiedeberg's archives of pharmacology 20060101

• Stimulation by bradykinin of HCO3- secretion in rat gastroduodenal mucosa.

  Medical science monitor : international medical journal of experimental and clinical research 20060101

• Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin.

  Apoptosis : an international journal on programmed cell death 20060101

• Effects of bee venom peptidergic components on rat pain-related behaviors and inflammation.

  Neuroscience 20060101

• Depression of presynaptic excitation by the activation of vanilloid receptor 1 in the rat spinal dorsal horn revealed by optical imaging.

  Molecular pain 20060101

• Effect of N-arachidonoyl-(2-methyl-4-hydroxyphenyl) amine (VDM11), an anandamide transporter inhibitor, on capsaicin-induced cough in mice.

  Cough (London, England) 20060101

• Capsaicin-resistant arterial baroreceptors.

  Journal of negative results in biomedicine 20060101

• Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels.

  Respiratory research 20060101

• The mu opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway.

  Molecular pain 20060101

• TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs.

  Cough (London, England) 20060101

• A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1.

  Nutritional neuroscience 20060101

• Recent advances in basic neurosciences and brain disease: from synapses to behavior.

  Molecular pain 20060101

• Molecular cloning, functional characterization of the porcine transient receptor potential V1 (pTRPV1) and pharmacological comparison with endogenous pTRPV1.

  Biochemical pharmacology 20051219

• Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors.

  Brain research 20051214

• TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice.

  Circulation 20051206

• Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs.

  The Journal of physiology 20051201

• The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs.

  American journal of physiology. Heart and circulatory physiology 20051201

• Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla.

  Neuropharmacology 20051201

• Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1.

  Molecular pharmacology 20051201

• The odontoblast as a sensory receptor cell? The expression of TRPV1 (VR-1) channels.

  Archives of histology and cytology 20051201

• TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues.

  Brain research bulletin 20051130

• The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20051123

• Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons.

  Brain research 20051116

• Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis.

  Neurobiology of disease 20051101

• Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed.

  The Journal of physiology 20051015

• Mechanisms underlying capsaicin-stimulated secretion in the stomach: comparison with mucosal acidification.

  The Journal of pharmacology and experimental therapeutics 20051001

• Icilin activates the delta-subunit of the human epithelial Na+ channel.

  Molecular pharmacology 20051001

• TRPV1 activation results in disruption of the blood-brain barrier in the rat.

  British journal of pharmacology 20051001

• Diuresis and natriuresis caused by activation of VR1-positive sensory nerves in renal pelvis of rats.

  Hypertension (Dallas, Tex. : 1979) 20051001

• Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors.

  British journal of pharmacology 20051001

• Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction.

  Journal of cell science 20051001

• VR1-mediated depressor effects during high-salt intake: role of anandamide.

  Hypertension (Dallas, Tex. : 1979) 20051001

• Cooling-induced contraction of the rat gastric fundus: mediation via transient receptor potential (TRP) cation channel TRPM8 receptor and Rho-kinase activation.

  Clinical and experimental pharmacology & physiology 20051001

• Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050928

• Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists.

  Bioorganic & medicinal chemistry letters 20050915

• Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists.

  Bioorganic & medicinal chemistry letters 20050915

• Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin.

  The Journal of physiology 20050915

• Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat.

  Neuroscience letters 20050909

• Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity.

  Molecular pharmacology 20050901

• Type II vanilloid receptor signaling system: one of the possible mechanisms for the rise in asthma cases.

  Frontiers in bioscience : a journal and virtual library 20050901

• Characteristics of propofol-evoked vascular pain in anaesthetized rats.

  British journal of anaesthesia 20050901

• Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation.

  British journal of pharmacology 20050901

• Heat and mechanical hyperalgesia in mice model of cancer pain.

  Pain 20050901

• Multiple types of sensory neurons respond to irritating volatile organic compounds (VOCs): calcium fluorimetry of trigeminal ganglion neurons.

  Pain 20050901

• Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.

  Pain 20050901

• Eugenol inhibits calcium currents in dental afferent neurons.

  Journal of dental research 20050901

• Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8.

  Molecular pharmacology 20050801

• Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways.

  British journal of pharmacology 20050801

• Capsazepine, a vanilloid receptor antagonist, inhibits allergen-induced tracheal contraction.

  European journal of pharmacology 20050725

• The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination.

  Journal of medicinal chemistry 20050714

• Vanilloid receptor expressed in the sarcoplasmic reticulum of rat skeletal muscle.

  Biochemical and biophysical research communications 20050708

• Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat.

  European journal of pharmacology 20050704

• A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid.

  The Journal of pharmacology and experimental therapeutics 20050701

• Characterization of rat transient receptor potential vanilloid 1 receptors lacking the N-glycosylation site N604.

  Neuroreport 20050621

• Sensory transduction of pulmonary reactive oxygen species by capsaicin-sensitive vagal lung afferent fibres in rats.

  The Journal of physiology 20050601

• The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.

  British journal of pharmacology 20050601

• Peripheral, but not central effects of cannabidiol derivatives: mediation by CB(1) and unidentified receptors.

  Neuropharmacology 20050601

• Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens.

  Neuropharmacology 20050601

• Expression of the transient receptor potential vanilloid 1 (TRPV1) in LNCaP and PC-3 prostate cancer cells and in human prostate tissue.

  European journal of pharmacology 20050516

• Hyperthermia increases sensitivity of pulmonary C-fibre afferents in rats.

  The Journal of physiology 20050515

• 2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels.

  American journal of physiology. Lung cellular and molecular physiology 20050501

• Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids.

  British journal of anaesthesia 20050501

• Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism.

  Stroke 20050501

• The protective effects of rutaecarpine on gastric mucosa injury in rats.

  Planta medica 20050501

• Cloning and functional characterization of dog transient receptor potential vanilloid receptor-1 (TRPV1).

  European journal of pharmacology 20050418

• Oleoylethanolamide excites vagal sensory neurones, induces visceral pain and reduces short-term food intake in mice via capsaicin receptor TRPV1.

  The Journal of physiology 20050415

• Differential responses of bladder lumbosacral and thoracolumbar dorsal root ganglion neurons to purinergic agonists, protons, and capsaicin.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050413

• Protective effects of Delta(9)-tetrahydrocannabinol against N-methyl-d-aspartate-induced AF5 cell death.

  Brain research. Molecular brain research 20050404

• AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.

  The Journal of pharmacology and experimental therapeutics 20050401

• TRPV1b, a functional human vanilloid receptor splice variant.

  Molecular pharmacology 20050401

• Transient receptor potential vanilloid (TRPV-1) promotes neurogenic inflammation in the pancreas via activation of the neurokinin-1 receptor (NK-1R).

  Pancreas 20050401

• Role of sensory neuron in reduction of endotoxin-induced hypotension in rats.

  Critical care medicine 20050401

• Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.

  Journal of medicinal chemistry 20050324

• Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050309

• Capsazepine, a vanilloid antagonist, abolishes tonic responses induced by 20-HETE on guinea pig airway smooth muscle.

  American journal of physiology. Lung cellular and molecular physiology 20050301

• Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils.

  British journal of pharmacology 20050301

• Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1).

  British journal of pharmacology 20050301

• CB(1) cannabinoid receptor stimulation modulates transient receptor potential vanilloid receptor 1 activities in calcium influx and substance P Release in cultured rat dorsal root ganglion cells.

  Journal of pharmacological sciences 20050301

• Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle.

  European journal of pharmacology 20050221

• Involvement of CGRP in the inhibitory effect of rutaecarpine on vasoconstriction induced by anaphylaxis in guinea pig.

  Regulatory peptides 20050215

• A biochemical and pharmacological examination of Rhamphiophis oxyrhynchus (Rufous beaked snake) venom.

  Toxicon : official journal of the International Society on Toxinology 20050201

• Vagal selective effects of ruthenium red on the jejunal afferent fibre response to ischaemia in the rat.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050201

• Involvement of peroxynitrite in capsaicin-induced apoptosis of C6 glioma cells.

  Neuroscience research 20050201

• AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation.

  European journal of pharmacology 20050131

• Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew).

  European journal of pharmacology 20050131

• Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050119

• Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides.

  Journal of medicinal chemistry 20050113

• Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1.

  The Journal of biological chemistry 20050107

• Role of capsaicin-sensitive primary afferent inputs from the masseter muscle in the C1 spinal neurons responding to tooth-pulp stimulation in rats.

  Experimental brain research 20050101

• Contribution of capsaicin-sensitive sensory neurons to antithrombin-induced reduction of ischemia/reperfusion-induced liver injury in rats.

  Thrombosis and haemostasis 20050101

• Lafutidine-induced increase in intracellular ca(2+) concentrations in PC12 and endothelial cells.

  Journal of pharmacological sciences 20050101

• A phospholipase C-dependent intracellular Ca2+ release pathway mediates the capsaicin-induced apoptosis in HepG2 human hepatoma cells.

  Archives of pharmacal research 20050101

• How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation.

  Molecular pain 20050101

• Multiple-signaling pathways are involved in the inhibitory effects of galangin on urinary bladder contractility.

  Neurourology and urodynamics 20050101

• Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells.

  Journal of biochemical and molecular toxicology 20050101

• Inflammatory mediators convert anandamide into a potent activator of the vanilloid type 1 transient receptor potential receptor in nociceptive primary sensory neurons.

  Neuroscience 20050101

• Contrasting phenotypes of putative proprioceptive and nociceptive trigeminal neurons innervating jaw muscle in rat.

  Molecular pain 20050101

• Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041215

• Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors.

  Brain research. Molecular brain research 20041206

• Expression of vanilloid VR1 receptor in PC12 cells.

  Neurochemistry international 20041201

• Distinct thymocyte subsets express the vanilloid receptor VR1 that mediates capsaicin-induced apoptotic cell death.

  Cell death and differentiation 20041201

• Lipopolysaccharide fever is initiated via a capsaicin-sensitive mechanism independent of the subtype-1 vanilloid receptor.

  British journal of pharmacology 20041201

• Current perspectives on the therapeutic utility of VR1 antagonists.

  Current medicinal chemistry 20041201

• Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium-induced colitis in mice.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20041201

• Protective effects of evodiamine on myocardial ischemia-reperfusion injury in rats.

  Planta medica 20041201

• Combined determination with functional and morphological studies of origin of nerve fibers expressing transient receptor potential vanilloid 1 in the myenteric plexus of the rat jejunum.

  Autonomic neuroscience : basic & clinical 20041130

• Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells.

  Cancer research 20041115

• Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction.

  Circulation research 20041112

• Cloning and pharmacological characterization of mouse TRPV1.

  Neuroscience letters 20041103

• Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel.

  Journal of applied physiology (Bethesda, Md. : 1985) 20041101

• Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice.

  The Journal of physiology 20041101

• Perivascular nerves induce cardiorespiratory reflexes in response to algogens in anaesthetised rats.

  Neuroscience research 20041101

• Inhibition of the vanilloid receptor subtype-1 attenuates TNBS-colitis.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20041101

• Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel.

  The Journal of biological chemistry 20041022

• Capsazepine elevates intracellular Ca2+ in human osteosarcoma cells, questioning its selectivity as a vanilloid receptor antagonist.

  Life sciences 20041008

• Characterization of the human HCN1 channel and its inhibition by capsazepine.

  British journal of pharmacology 20041001

• Ischemic preconditioning of remote organs attenuates gastric ischemia-reperfusion injury through involvement of prostaglandins and sensory nerves.

  European journal of pharmacology 20040919

• Stimulation of calcitonin gene-related peptide synthesis and release: mechanisms for a novel antihypertensive drug, rutaecarpine.

  Journal of hypertension 20040901

• Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation.

  British journal of pharmacology 20040901

• Antitussive activity of iodo-resiniferatoxin in guinea pigs.

  Thorax 20040901

• Nociceptin inhibits vanilloid TRPV-1-mediated neurosensitization induced by fenoterol in human isolated bronchi.

  Naunyn-Schmiedeberg's archives of pharmacology 20040901

• AM404 enhances the spontaneous release of L-glutamate in a manner sensitive to capsazepine in adult rat substantia gelatinosa neurones.

  Brain research 20040827

• Evodiamine functions as an agonist for the vanilloid receptor TRPV1.

  Organic & biomolecular chemistry 20040821

• Regulation of calcitonin gene-related peptide release from rat trigeminal nucleus caudalis slices in vitro.

  Neuroscience letters 20040819

• Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats.

  Biochemical and biophysical research communications 20040813

• Anandamide transport inhibitor AM404 and structurally related compounds inhibit synaptic transmission between rat hippocampal neurons in culture independent of cannabinoid CB1 receptors.

  European journal of pharmacology 20040802

• Functional TRPV4 channels are expressed in human airway smooth muscle cells.

  American journal of physiology. Lung cellular and molecular physiology 20040801

• Vanilloid receptors mediate adrenergic nerve- and CGRP-containing nerve-dependent vasodilation induced by nicotine in rat mesenteric resistance arteries.

  British journal of pharmacology 20040801

• Inhibition by anandamide and synthetic cannabimimetics of the release of [3H]D-aspartate and [3H]GABA from synaptosomes isolated from the rat hippocampus.

  Neurochemical research 20040801

• Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors.

  British journal of pharmacology 20040801

• The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints.

  British journal of pharmacology 20040801

• [Functional analysis of acid sensing ion channels].

  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20040801

• Discovery of small molecule antagonists of TRPV1.

  Bioorganic & medicinal chemistry letters 20040716

• TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells.

  Cell calcium 20040701

• The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant.

  The Journal of physiology 20040701

• TRPV1 and CB(1) receptor-mediated effects of the endovanilloid/endocannabinoid N-arachidonoyl-dopamine on primary afferent fibre and spinal cord neuronal responses in the rat.

  The European journal of neuroscience 20040701

• Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.

  Urology 20040701

• N-isoquinolin-5-yl-N'-aralkyl-urea and -amide antagonists of human vanilloid receptor 1.

  Bioorganic & medicinal chemistry letters 20040621

• Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: role of oestrogens.

  European journal of pharmacology 20040616

• Ethanol causes inflammation in the airways by a neurogenic and TRPV1-dependent mechanism.

  The Journal of pharmacology and experimental therapeutics 20040601

• Effects of TRPV1 receptor antagonists on stimulated iCGRP release from isolated skin of rats and TRPV1 mutant mice.

  Pain 20040601

• Presynaptic cannabinoid CB(1) receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats.

  British journal of pharmacology 20040601

• Vanilloid receptor TRPV1 antagonists as the next generation of painkillers. Are we putting the cart before the horse?

  Journal of medicinal chemistry 20040520

• Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040519

• The analgesic effect induced by capsaicin is enhanced in inflammatory states.

  Life sciences 20040514

• Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence.

  Brain research 20040508

• Molecular determinants of vanilloid sensitivity in TRPV1.

  The Journal of biological chemistry 20040507

• Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/TRPV1 pathway in rat sensory neurons.

  Neuroscience letters 20040506

• Activation of capsaicin-sensitive sensory neurons by carvedilol, a nonselective beta-blocker, in spontaneous hypertensive rats.

  The Journal of pharmacology and experimental therapeutics 20040501

• Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels.

  Cell calcium 20040501

• Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.

  British journal of pharmacology 20040501

• Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.

  The Journal of biological chemistry 20040423

• Inhibitory effect of ginger (Zingiber officinale) on rat ileal motility in vitro.

  Life sciences 20040423

• N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.

  Bioorganic & medicinal chemistry letters 20040405

• Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists.

  Bioorganic & medicinal chemistry letters 20040405

• Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide.

  British journal of pharmacology 20040401

• Multiple actions of anandamide on neonatal rat cultured sensory neurones.

  British journal of pharmacology 20040401

• Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats.

  Scandinavian journal of gastroenterology 20040401

• Characterization of capsaicin-induced, capsazepine-insensitive relaxation of ileal smooth muscle of rats.

  European journal of pharmacology 20040308

• Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines.

  The Journal of pharmacology and experimental therapeutics 20040301

• TRPV1 receptors mediate particulate matter-induced apoptosis.

  American journal of physiology. Lung cellular and molecular physiology 20040301

• Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors.

  Progress in neuro-psychopharmacology & biological psychiatry 20040301

• Characterisation of the vasorelaxant properties of the novel endocannabinoid N-arachidonoyl-dopamine (NADA).

  British journal of pharmacology 20040301

• Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice.

  British journal of pharmacology 20040301

• Background potassium channel block and TRPV1 activation contribute to proton depolarization of sensory neurons from humans with neuropathic pain.

  The European journal of neuroscience 20040301

• An efficient parallel synthesis of capsazepine and capsazepine analogs.

  Combinatorial chemistry & high throughput screening 20040301

• An assessment of vascular pain using the flexor reflex in anesthetized rats.

  Methods and findings in experimental and clinical pharmacology 20040301

• N-4-Substituted-benzyl-N'-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity.

  Bioorganic & medicinal chemistry letters 20040209

• Design of a high-affinity competitive antagonist of the vanilloid receptor selective for the calcium entry-linked receptor population.

  Molecular pharmacology 20040201

• Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay.

  British journal of pharmacology 20040201

• 7-Hydroxynaphthalen-1-yl-urea and -amide antagonists of human vanilloid receptor 1.

  Bioorganic & medicinal chemistry letters 20040119

• N-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure-activity relationships for the 'C-Region'.

  Bioorganic & medicinal chemistry 20040115

• Cannabinoids modulate neuronal firing in the rat basolateral amygdala: evidence for CB1- and non-CB1-mediated actions.

  Neuropharmacology 20040101

• Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist.

  Neuropharmacology 20040101

• An investigation of the effects of ruthenium red, nitric oxide and endothelin-1 on infrared receptor activity in a crotaline snake.

  Neuroscience 20040101

• Proton conductance of human transient receptor potential-vanilloid type-1 expressed in oocytes of Xenopus laevis and in Chinese hamster ovary cells.

  Neuroscience 20040101

• Differential pH and capsaicin responses of Griffonia simplicifolia IB4 (IB4)-positive and IB4-negative small sensory neurons.

  Neuroscience 20040101

• Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells.

  Journal of medicinal food 20040101

• Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects.

  Bioorganic & medicinal chemistry letters 20031215

• Contribution of capsaicin-sensitive sensory neurons to stress-induced increases in gastric tissue levels of prostaglandins in rats.

  American journal of physiology. Gastrointestinal and liver physiology 20031201

• A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia.

  Anesthesiology 20031201

• The endogenous cannabinoid, anandamide, activates the hypothalamo-pituitary-adrenal axis in CB1 cannabinoid receptor knockout mice.

  Neuroendocrinology 20031201

• Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting I(h).

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20031105

• Capsaicin-sensitive neurogenic sensory vasodilatation in the dura mater of the rat.

  The Journal of physiology 20031101

• Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages.

  British journal of pharmacology 20031101

• Insulin induces cobalt uptake in a subpopulation of rat cultured primary sensory neurons.

  The European journal of neuroscience 20031101

• Thermal properties of acid-induced depolarization in cultured rat small primary afferent neurons.

  Neuroscience letters 20031023

• 4-(2-pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists.

  Bioorganic & medicinal chemistry letters 20031020

• Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM.

  Journal of neurophysiology 20031001

• Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20031001

• A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries: involvement of CGRP, NO, cGMP, and endothelium-dependent activities.

  Journal of cardiovascular pharmacology 20031001

• Activation of vanilloid receptor 1 (VR1) by eugenol.

  Journal of dental research 20031001

• Vanilloid type 1 receptors (VR1) on trigeminal sensory nerve fibres play a minor role in neurogenic dural vasodilatation, and are involved in capsaicin-induced dural dilation.

  British journal of pharmacology 20031001

• Vanilloid receptor activation by 2- and 10-microm particles induces responses leading to apoptosis in human airway epithelial cells.

  Toxicology and applied pharmacology 20031001

• Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action.

  The European journal of neuroscience 20031001

• Expression of vanilloid receptors in rat gastric epithelial cells: role in cellular protection.

  Biochemical pharmacology 20030915

• Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid.

  Biochemical pharmacology 20030901

• An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice.

  Gastroenterology 20030901

• Stimulation by capsaicin of duodenal HCO3(-) secretion via afferent neurons and vanilloid receptors in rats: comparison with acid-induced HCO3(-) response.

  Digestive diseases and sciences 20030901

• Capsaicin-like effects of N-arachidonoyl-dopamine in the isolated guinea pig bronchi and urinary bladder.

  European journal of pharmacology 20030815

• Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists.

  British journal of pharmacology 20030802

• Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice.

  The Journal of pharmacology and experimental therapeutics 20030801

• Function and regulation of the vanilloid receptor in rats fed a high salt diet.

  Journal of hypertension 20030801

• Involvement of vanilloid receptors in heat stress-induced delayed protection against myocardial ischemia-reperfusion injury.

  Neuropeptides 20030801

• Mechanisms of sensitization of the response of single dorsal root ganglion cells from adult rat to noxious heat.

  The European journal of neuroscience 20030801

• Proton-induced calcitonin gene-related peptide release from rat sciatic nerve axons, in vitro, involving TRPV1.

  The European journal of neuroscience 20030801

• Modifications of capsaicin-sensitive neurons in isolated guinea pig ileum by [6]-gingerol and lafutidine.

  Journal of pharmacological sciences 20030801

• Albaconol from the mushroom Albatrellus confluens induces contraction and desensitization in guinea pig trachea.

  Planta medica 20030801

• N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.

  Journal of medicinal chemistry 20030703

• Vanilloid receptors in hearing: altered cochlear sensitivity by vanilloids and expression of TRPV1 in the organ of corti.

  Journal of neurophysiology 20030701

• N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain.

  The Journal of pharmacology and experimental therapeutics 20030701

• N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.

  The Journal of pharmacology and experimental therapeutics 20030701

• New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro.

  Peptides 20030701

• Involvement of capsaicin-sensitive sensory nerves in cardioprotection of rutaecarpine in rats.

  Regulatory peptides 20030615

• Calcium signaling in single peripheral sensory nerve terminals.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615

• The effects of local and intravenous anesthetics on recombinant rat VR1 vanilloid receptors.

  Anesthesia and analgesia 20030601

• Electrostatic charge activates inflammatory vanilloid (VR1) receptors.

  Neurotoxicology 20030601

• Adrenergic regulation of capsaicin-sensitive neurons in dental pulp.

  Journal of endodontics 20030601

• Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts.

  Cellular and molecular life sciences : CMLS 20030601

• Inhibitory effect of the plant flavonoid galangin on rat vas deferens in vitro.

  Life sciences 20030516

• Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030515

• Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists.

  Bioorganic & medicinal chemistry letters 20030505

• Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats.

  Gut 20030501

• Capsaicin-induced reactivation of latent herpes simplex virus type 1 in sensory neurons in culture.

  The Journal of general virology 20030501

• State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury.

  Journal of neurochemistry 20030501

• Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications.

  Thrombosis and haemostasis 20030501

• Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors.

  Toxicological sciences : an official journal of the Society of Toxicology 20030501

• The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice.

  Planta medica 20030501

• Peripheral tackykinin and excitatory amino acid receptors mediate hyperalgesia induced by Phoneutria nigriventer venom.

  European journal of pharmacology 20030425

• Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug.

  European journal of pharmacology 20030425

• Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030415

• The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro.

  The Journal of physiology 20030401

• Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in mice.

  Pharmacology, biochemistry, and behavior 20030401

• Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages.

  Cellular signalling 20030301

• Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.

  Journal of neurochemistry 20030301

• A role for TRPV1 in bradykinin-induced excitation of vagal airway afferent nerve terminals.

  The Journal of pharmacology and experimental therapeutics 20030301

• Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor.

  Molecular pharmacology 20030301

• Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor.

  Hypertension (Dallas, Tex. : 1979) 20030301

• Neurogenic responses mediated by vanilloid receptor-1 (TRPV1) are blocked by the high affinity antagonist, iodo-resiniferatoxin.

  British journal of pharmacology 20030301

• Synthesis of N,N',N'-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor.

  Bioorganic & medicinal chemistry letters 20030224

• Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells.

  Biochemical pharmacology 20030215

• Versatile regulation of cytosolic Ca2+ by vanilloid receptor I in rat dorsal root ganglion neurons.

  The Journal of biological chemistry 20030214

• Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1).

  The Journal of pharmacology and experimental therapeutics 20030201

• The depressor and vasodilator effects of rutaecarpine are mediated by calcitonin gene-related peptide.

  Planta medica 20030201

• Synthesis of 2-substituted-pyrrolidinethiourea derivatives and their antagonist effect on vanilloid receptor.

  Bioorganic & medicinal chemistry letters 20030120

• Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae.

  Neuroscience letters 20030116

• Negatively charged 2- and 10-microm particles activate vanilloid receptors, increase cAMP, and induce cytokine release.

  Toxicology and applied pharmacology 20030115

• R+-methanandamide inhibits tracheal response to endogenously released acetylcholine via capsazepine-sensitive receptors.

  European journal of pharmacology 20030110

• The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain.

  The Journal of pharmacology and experimental therapeutics 20030101

• Potentiation of anandamide effects in mesenteric beds isolated from endotoxemic rats.

  The Journal of pharmacology and experimental therapeutics 20030101

• Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes.

  The Journal of pharmacology and experimental therapeutics 20030101

• Neurokinin release produced by capsaicin acting on the central terminals and axons of primary afferents: relationship with N-methyl-D-aspartate and GABA(B) receptors.

  Neuroscience 20030101

• Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin.

  The Journal of pharmacology and experimental therapeutics 20021201

• Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors.

  British journal of anaesthesia 20021201

• Effect of olvanil (N-vanillyl-cis-9-octadecenoamide) on cytosolic Ca2+ increase in renal tubular cells.

  Life sciences 20021115

• Upregulation of proinflammatory cytokines and nerve growth factor by intraplantar injection of capsaicin in rats.

  The Journal of physiology 20021115

• Characterization of the vanilloid receptor 1 antagonist iodo-resiniferatoxin on the afferent and efferent function of vagal sensory C-fibers.

  The Journal of pharmacology and experimental therapeutics 20021101

• Gingerols: a novel class of vanilloid receptor (VR1) agonists.

  British journal of pharmacology 20021101

• Anandamide induces cough in conscious guinea-pigs through VR1 receptors.

  British journal of pharmacology 20021101

• Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.

  The Journal of clinical investigation 20021015

• High affinity antagonists of the vanilloid receptor.

  Molecular pharmacology 20021001

• Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons.

  British journal of pharmacology 20021001

• Cellular mechanisms of nociception in the frog.

  Journal of neurophysiology 20021001

• The putative role of vanilloid receptor-like protein-1 in mediating high threshold noxious heat-sensitivity in rat cultured primary sensory neurons.

  The European journal of neuroscience 20021001

• Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor.

  Journal of biomolecular screening 20021001

• Effect of piperine, the active ingredient of black pepper, on intestinal secretion in mice.

  Life sciences 20020927

• Protein kinase C(alpha) is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathways.

  The Journal of biological chemistry 20020920

• Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020915

• Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists.

  Molecular pharmacology 20020901

• Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve.

  British journal of pharmacology 20020901

• Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020901

• Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020901

• Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro.

  The Journal of physiology 20020901

• Mechanisms of acid-induced activation of airway afferent nerve fibres in guinea-pig.

  The Journal of physiology 20020901

• Cloning and functional characterization of the guinea pig vanilloid receptor 1.

  Neuropharmacology 20020901

• Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers.

  Neuropharmacology 20020901

• Binding, degradation and apoptotic activity of stearoylethanolamide in rat C6 glioma cells.

  The Biochemical journal 20020815

• The cardioprotection of rutaecarpine is mediated by endogenous calcitonin related-gene peptide through activation of vanilloid receptors in guinea-pig hearts.

  Planta medica 20020801

• Effects of peripheral nerve injury on functional spinal VR1 receptors.

  Neuroreport 20020702

• Activation of protein kinase C sensitizes human VR1 to capsaicin and to moderate decreases in pH at physiological temperatures in Xenopus oocytes.

  Pain 20020701

• A heat-sensitive TRP channel expressed in keratinocytes.

  Science (New York, N.Y.) 20020614

• Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1.

  Nature neuroscience 20020601

• Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent.

  American journal of physiology. Heart and circulatory physiology 20020601

• The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons.

  The Journal of pharmacology and experimental therapeutics 20020601

• DRASIC contributes to pH-gated currents in large dorsal root ganglion sensory neurons by forming heteromultimeric channels.

  Journal of neurophysiology 20020601

• Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats.

  Japanese journal of pharmacology 20020601

• Contractile response to a cannabimimetic eicosanoid, 2-arachidonoylglycerol, of longitudinal smooth muscle from the guinea-pig distal colon in vitro.

  European journal of pharmacology 20020531

• Comparison of capsaicin-evoked calcium transients between rat nodose and jugular ganglion neurons.

  Autonomic neuroscience : basic & clinical 20020531

• Spinal administration of capsazepine inhibits noxious evoked responses of dorsal horn neurons in non-inflamed and carrageenan inflamed rats.

  Brain research 20020510

• 3-D-QSAR analysis of N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline and N-(3-acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thioureas analogues as potent vanilloid receptor ligands.

  Bioorganic & medicinal chemistry 20020501

• Gastric hyperemic response induced by acid back-diffusion in rat stomachs following barrier disruption -- relation to vanilloid type-1 receptors.

  Medical science monitor : international medical journal of experimental and clinical research 20020501

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2.

  Clinical and experimental pharmacology & physiology 20020401

• Ischemia/reperfusion-induced increase in the hepatic level of prostacyclin is mainly mediated by activation of capsaicin-sensitive sensory neurons in rats.

  The Journal of laboratory and clinical medicine 20020401

• Interaction between vanilloid and glutamate receptors in the central modulation of nociception.

  European journal of pharmacology 20020329

• Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors.

  European journal of pharmacology 20020329

• Stimulation of pulmonary vagal C-fibres by anandamide in anaesthetized rats: role of vanilloid type 1 receptors.

  The Journal of physiology 20020315

• Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers.

  Circulation research 20020308

• Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts.

  British journal of pharmacology 20020301

• Relaxant effect of capsazepine in the isolated rat ileum.

  Naunyn-Schmiedeberg's archives of pharmacology 20020301

• Functional vanilloid receptors in cultured normal human epidermal keratinocytes.

  Biochemical and biophysical research communications 20020215

• Particulate matter inflammation and receptor sensitivity are target cell specific.

  Inhalation toxicology 20020201

• Pharmacological characterization of vanilloid receptor located in the brain.

  Brain research. Molecular brain research 20020131

• Simultaneous intracellular calcium and sodium flux imaging in human vanilloid receptor 1 (VR1)-transfected human embryonic kidney cells: a method to resolve ionic dependence of VR1-mediated cell death.

  The Journal of pharmacology and experimental therapeutics 20020101

• Activation of capsaicin receptors on the sciatic nerve induces FOS expression in the spinal dorsal horn of adult rats.

  Neuro-Signals 20020101

• Effects of ginsenosides on vanilloid receptor (VR1) channels expressed in Xenopus oocytes.

  Molecules and cells 20011231

• Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae.

  Brain research 20011227

• Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors.

  The Journal of pharmacology and experimental therapeutics 20011201

• The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice.

  Neuropharmacology 20011201

• Anandamide and methanandamide induce both vanilloid VR1- and cannabinoid CB1 receptor-mediated changes in heart rate and blood pressure in anaesthetized rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20011201

• Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.

  Life sciences 20011102

• Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis.

  American journal of physiology. Gastrointestinal and liver physiology 20011101

• Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels.

  British journal of pharmacology 20011101

• Capsaicin-, resiniferatoxin-, and olvanil-induced adrenaline secretions in rats via the vanilloid receptor.

  Bioscience, biotechnology, and biochemistry 20011101

• Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells.

  Neuroscience letters 20011012

• Stimulatory effect of centrally injected capsaicin, an agonist of vanilloid receptors, on gastric acid secretion in rats.

  European journal of pharmacology 20011012

• Capsaicin inhibits Jurkat T-cell activation by blocking calcium entry current I(CRAC).

  The Journal of pharmacology and experimental therapeutics 20011001

• Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1.

  British journal of pharmacology 20011001

• Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in the anaesthetized rat.

  British journal of pharmacology 20011001

• Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.

  British journal of pharmacology 20011001

• Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries.

  British journal of pharmacology 20011001

• Capsaicin-evoked CGRP release from rat buccal mucosa: development of a model system for studying trigeminal mechanisms of neurogenic inflammation.

  The European journal of neuroscience 20011001

• Noxious heat-induced CGRP release from rat sciatic nerve axons in vitro.

  The European journal of neuroscience 20011001

• Long-term inhibition of nitric oxide synthase potentiates effects of anandamide in the rat mesenteric bed.

  European journal of pharmacology 20010921

• The capsaicin VR1 receptor mediates substance P release in toxin A-induced enteritis in rats.

  Peptides 20010901

• A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.

  British journal of pharmacology 20010901

• Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors.

  British journal of pharmacology 20010901

• Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1.

  The Journal of biological chemistry 20010817

• Effects of capsaicin on Ca(2+) release from the intracellular Ca(2+) stores in the dorsal root ganglion cells of adult rats.

  Biochemical and biophysical research communications 20010803

• Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide.

  The Journal of physiology 20010801

• CH-19 sweet, nonpungent cultivar of red pepper, increased body temperature in mice with vanilloid receptors stimulation by capsiate.

  Journal of nutritional science and vitaminology 20010801

• Analysis of the native quaternary structure of vanilloid receptor 1.

  The Journal of biological chemistry 20010727

• Cannabinoid activation of recombinant and endogenous vanilloid receptors.

  European journal of pharmacology 20010727

• Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide.

  European journal of pharmacology 20010706

• Effects of capsaicin on human intestinal cell line Caco-2.

  Cytotechnology 20010701

• Genital grooming and emesis induced by vanilloids in Suncus murinus, the house musk shrew.

  European journal of pharmacology 20010622

• Vanilloid receptor expression and capsaicin excitation of rat dental primary afferent neurons.

  Journal of dental research 20010601

• Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues.

  European journal of pharmacology 20010525

• Capsaicin-induced relaxation in rabbit coronary artery.

  The Journal of veterinary medical science 20010501

• Mechanism of atropine-resistant contraction induced by Dai-kenchu-to in guinea pig ileum.

  Japanese journal of pharmacology 20010501

• The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism.

  The Journal of biological chemistry 20010420

• Low pH modulation of recombinant vanilloid receptors and perivascular capsaicin-sensitive sensory neurotransmission.

  Autonomic neuroscience : basic & clinical 20010412

• Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology.

  European journal of pharmacology 20010406

• Effect of vanilloid drugs on gastrointestinal transit in mice.

  British journal of pharmacology 20010401

• Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from rat trigeminal ganglion: evidence for intraganglionic neurotransmission.

  Pain 20010401

• The positive inotropic and chronotropic effects of evodiamine and rutaecarpine, indoloquinazoline alkaloids isolated from the fruits of Evodia rutaecarpa, on the guinea-pig isolated right atria: possible involvement of vanilloid receptors.

  Planta medica 20010401

• Capsazepine, a vanilloid receptor antagonist, inhibits the expression of inducible nitric oxide synthase gene in lipopolysaccharide-stimulated RAW264.7 macrophages through the inactivation of nuclear transcription factor-kappa B.

  International immunopharmacology 20010401

• Sensory pathways and cyclooxygenase regulate mucus gel thickness in rat duodenum.

  American journal of physiology. Gastrointestinal and liver physiology 20010301

• Pharmacological differences between the human and rat vanilloid receptor 1 (VR1).

  British journal of pharmacology 20010301

• The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways.

  British journal of pharmacology 20010301

• Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010215

• Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints.

  British journal of pharmacology 20010201

• Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens.

  British journal of pharmacology 20010201

• Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons.

  Journal of neurophysiology 20010201

• Regional differences in anandamide- and methanandamide-induced membrane potential changes in rat mesenteric arteries.

  The Journal of pharmacology and experimental therapeutics 20010201

• ACTH inhibits the capsaicin-evoked release of CGRP from rat adrenal afferent nerves.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010101

• Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist.

  Molecular pharmacology 20010101

• Characterization of a novel mechanism accounting for the adverse cholinergic effects of the anticancer drug irinotecan.

  British journal of pharmacology 20010101

• Comparison of intracellular calcium signals evoked by heat and capsaicin in cultured rat dorsal root ganglion neurons and in a cell line expressing the rat vanilloid receptor, VR1.

  Neuroscience 20010101

• Changes in cytosolic calcium in response to noxious heat and their relationship to vanilloid receptors in rat dorsal root ganglion neurons.

  Neuroscience 20010101

• Pharmacology of airway afferent nerve activity.

  Respiratory research 20010101

• Induction of vanilloid receptor channel activity by protein kinase C.

  Nature 20001201

• Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology.

  British journal of pharmacology 20000601

• Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances.

  Proceedings of the National Academy of Sciences of the United States of America 20000523

• The anandamide transport inhibitor AM404 activates vanilloid receptors.

  European journal of pharmacology 20000512

• Involvement of vanilloid receptors and purinoceptors in the Phoneutria nigriventer spider venom-induced plasma extravasation in rat skin.

  European journal of pharmacology 20000317

• Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide.

  Nature 19990729

• Identification of the L-menthol binding site in guinea-pig lung membranes.

  British journal of pharmacology 19980201

• Mechanism of acid-induced mesenteric hyperemia in rats.

  Life sciences 19980101

• The selective capsaicin antagonist capsazepine abolishes the antinociceptive action of eugenol and guaiacol.

  Journal of dental research 19970401

• Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors.

  British journal of pharmacology 19960801

• Release of beta-endorphin immunoreactivity into ventriculo-cisternal perfusate by lumbar intrathecal capsaicin in the rat.

  Brain research 19951201

• Evidence that glutamate is released from capsaicin-sensitive primary afferent fibers in rats: study with on-line continuous monitoring of glutamate.

  Neuroscience research 19940901

• Regulation of neuropeptide release from pulmonary capsaicin-sensitive afferents in relation to bronchoconstriction.

  Acta physiologica Scandinavica. Supplementum 19930101