1392399-03-9 | BIX-01294 Trihydrochloride

Packsize	Purity	Availability	Price	Discounted Price
1mg	99+%	in stock	$14.00	$10.00
5mg	99+%	in stock	$33.00	$23.00
10mg	99+%	in stock	$56.00	$39.00
25mg	99+%	in stock	$103.00	$72.00

Description

• Catalog Number: AE39363
• Chemical Name: BIX-01294 Trihydrochloride
• CAS Number: 1392399-03-9
• Molecular Formula: C28H41Cl3N6O2
• Molecular Weight: 600.0231
• MDL Number: MFCD16618384
• SMILES: COc1cc2nc(nc(c2cc1OC)NC1CCN(CC1)Cc1ccccc1)N1CCCN(CC1)C.Cl.Cl.Cl

Computed Properties

• Complexity: 656
• Covalently-Bonded Unit Count: 4
• Heavy Atom Count: 39
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 7

Literature

• Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment.

  PloS one 20140101

• Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death.

  Cell death & disease 20130201

• Abnormal histone H3K9 dimethylation but normal dimethyltransferase EHMT2 expression in cloned sheep embryos.

  Theriogenology 20121201

• Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum.

  Proceedings of the National Academy of Sciences of the United States of America 20121009

• Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4(+) T cells from HIV-1-infected HAART-treated patients.

  AIDS (London, England) 20120731

• Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines.

  The Journal of antibiotics 20120501

• G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120418

• Detecting S-adenosyl-L-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay.

  Analytical biochemistry 20120401

• An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases.

  Journal of molecular biology 20120224

• IVMBIX-01294, an inhibitor of the histone methyltransferase EHMT2, disrupts histone H3 lysine 9 (H3K9) dimethylation in the cleavage-stage porcine embryo.

  Reproduction, fertility, and development 20120101

• The effect of epigenetic factors on differentiation of pancreatic progenitor cells into insulin-producing cells.

  Transplantation proceedings 20111101

• Epigenetic regulation of HIV-1 transcription.

  Epigenomics 20110801

• Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.

  Journal of molecular biology 20100702

• Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294.

  The Journal of biological chemistry 20100528

• A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors.

  Molecular bioSystems 20100510

• Chromatin flow cytometry identifies changes in epigenetic cell states.

  Cells, tissues, organs 20100101

• Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.

  Nature structural & molecular biology 20090301

• Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.

  Cell stem cell 20081106

• Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

  Molecular cell 20070209