-
CaMKⅡ mediates cadmium induced apoptosis in rat primary osteoblasts through MAPK activation and endoplasmic reticulum stress.
Toxicology 20180801
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Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells.
Environmental toxicology 20170601
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Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170201
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Involvement of calcium/calmodulin-dependent protein kinase II in methamphetamine-induced neural damage.
Journal of applied toxicology : JAT 20161101
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Pleiotropic roles of Ca(+2)/calmodulin-dependent pathways in regulating cadmium-induced toxicity in human osteoblast-like cell lines.
Toxicology letters 20161017
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The toxic effects of Bisphenol A on the mouse spermatocyte GC-2 cell line: the role of the Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II axis.
Journal of applied toxicology : JAT 20151101
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Oral administration of bisphenol A induces high blood pressure through angiotensin II/CaMKII-dependent uncoupling of eNOS.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20141101
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Cadmium-induced aggregation of iron regulatory protein-1.
Toxicology 20141003
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Caffeine induces cardiomyocyte hypertrophy via p300 and CaMKII pathways.
Chemico-biological interactions 20140925
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Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium.
Archives of toxicology 20131201
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A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
The Biochemical journal 20130415
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Quantitative phosphoproteomic analysis of early alterations in protein phosphorylation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Journal of proteome research 20130201
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Involvement of CaMK-IIδ and gelsolin in Cd(2+) -dependent cytoskeletal effects in mesangial cells.
Journal of cellular physiology 20130101
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Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Heart rhythm 20121101
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Involvement of CaM kinase II in the impairment of endothelial function and eNOS activity in aortas of Type 2 diabetic rats.
Clinical science (London, England : 1979) 20120901
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Calcium/calmodulin-dependent kinase inhibitor induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20120801
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Acute exposure of L6 myotubes to cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid isomers stimulates glucose uptake by modulating Ca2+/calmodulin-dependent protein kinase II.
The international journal of biochemistry & cell biology 20120801
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CaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle.
American journal of physiology. Gastrointestinal and liver physiology 20120715
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Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.
Circulation 20120501
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Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20120418
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Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes.
American journal of physiology. Cell physiology 20120415
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Calcium/calmodulin dependent kinase II contributes to persistent central neuropathic pain following spinal cord injury.
Pain 20120301
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Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death.
Circulation research 20120217
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Chronic CaMKII inhibition blunts the cardiac contractile response to exercise training.
European journal of applied physiology 20120201
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Examining the effect of the CaMKII inhibitor administration in the locus coeruleus on the naloxone-precipitated morphine withdrawal signs in rats.
Behavioural brain research 20120115
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Domain-dependent modulation of insulin-induced AS160 phosphorylation and glucose uptake by Ca2+/calmodulin-dependent protein kinase II in L6 myotubes.
Cellular signalling 20120101
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Inhibition of Ca2+/calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in rats.
Molecular pain 20120101
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CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death.
Journal of neurochemistry 20111201
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Calcium-calmodulin kinase II mediates digitalis-induced arrhythmias.
Circulation. Arrhythmia and electrophysiology 20111201
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CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes.
Journal of molecular and cellular cardiology 20111101
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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Nature biotechnology 20111101
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Cross-talk among intracellular signaling pathways mediates the diphenyl ditelluride actions on the hippocampal cytoskeleton of young rats.
Chemical research in toxicology 20111017
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Ionizing radiation induces migration of glioblastoma cells by activating BK K(+) channels.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20111001
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Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.
American journal of physiology. Heart and circulatory physiology 20111001
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Specific effects of BCL10 Serine mutations on phosphorylations in canonical and noncanonical pathways of NF-κB activation following carrageenan.
American journal of physiology. Gastrointestinal and liver physiology 20110901
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TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts.
Biochemical and biophysical research communications 20110506
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Excitotoxic neuroprotection and vulnerability with CaMKII inhibition.
Molecular and cellular neurosciences 20110401
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Nicotinic stimulation of catecholamine synthesis and tyrosine hydroxylase phosphorylation in cervine adrenal medullary chromaffin cells.
Journal of neuroendocrinology 20110301
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Activation of CaMKII and ERK1/2 contributes to the time-dependent potentiation of Ca2+ response elicited by repeated application of capsaicin in rat DRG neurons.
American journal of physiology. Regulatory, integrative and comparative physiology 20110301
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Structure and activity relationship of 2-(substituted benzoyl)-hydroxyindoles as novel CaMKII inhibitors.
Bioorganic & medicinal chemistry letters 20110301
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Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production.
Journal of molecular endocrinology 20110201
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Ryanodine receptor-2 upregulation and nicotine-mediated plasticity.
The EMBO journal 20110105
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Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20110105
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Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia.
Journal of molecular and cellular cardiology 20110101
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Angiotensin II induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling.
Journal of molecular and cellular cardiology 20110101
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Signaling pathways in ascidian oocyte maturation: the roles of cAMP/Epac, intracellular calcium levels, and calmodulin kinase in regulating GVBD.
Molecular reproduction and development 20110101
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Inhibitory effect of chlorpromazine on RANKL-induced osteoclastogenesis in mouse bone marrow cells.
Journal of pharmacological sciences 20110101
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On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats.
Molecular pain 20110101
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Calcium/calmodulin-dependent kinase II facilitated GluR6 subunit serine phosphorylation through GluR6-PSD95-CaMKII signaling module assembly in cerebral ischemia injury.
Brain research 20101217
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Akti-1/2, an allosteric inhibitor of Akt 1 and 2, efficiently inhibits CaMKIα activity and aryl hydrocarbon receptor pathway.
Chemico-biological interactions 20101205
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5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors.
Bioorganic & medicinal chemistry letters 20101115
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Mechanosensitive transient receptor potential vanilloid type 1 channels contribute to vascular remodeling of rat fistula veins.
Journal of vascular surgery 20101101
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Murine vasa recta pericyte chloride conductance is controlled by calcium, depolarization, and kinase activity.
American journal of physiology. Regulatory, integrative and comparative physiology 20101101
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The role of CaMKII in calcium-activated death pathways in bone marrow B cells.
Toxicological sciences : an official journal of the Society of Toxicology 20101101
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A crosstalk between β1 and β3 integrins controls glycine receptor and gephyrin trafficking at synapses.
Nature neuroscience 20101101
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Hyperactive mice show elevated D2(High) receptors, a model for schizophrenia: Calcium/calmodulin-dependent kinase II alpha knockouts.
Synapse (New York, N.Y.) 20101001
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Molecular mechanisms in hippocampus and basolateral amygdala but not in parietal or cingulate cortex are involved in extinction of one-trial avoidance learning.
Neurobiology of learning and memory 20100901
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Abscisic acid activates a Ca2+-calmodulin-stimulated protein kinase involved in antioxidant defense in maize leaves.
Acta biochimica et biophysica Sinica 20100901
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CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin.
Neuron 20100729
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Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor.
The Journal of biological chemistry 20100702
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Ca(2+)/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na(+)/H(+) exchanger activation.
Journal of molecular and cellular cardiology 20100701
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Localised Ca channel phosphorylation modulates the distribution of L-type Ca current in cardiac myocytes.
Journal of molecular and cellular cardiology 20100701
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Effects of sarcolemmal Ca(2+) entry, ryanodine function, and kinase inhibitors on a rabbit model of heart failure.
International heart journal 20100701
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Regulation of intracellular pH by Ca2+-activated proton channel.
Immunopharmacology and immunotoxicology 20100601
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Ginsenoside Rg1 promotes glutamate release via a calcium/calmodulin-dependent protein kinase II-dependent signaling pathway.
Brain research 20100528
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The contribution of calcium/calmodulin-dependent protein-kinase II (CaMKII) to short-term plasticity at the neuromuscular junction.
Brain research bulletin 20100405
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CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation.
Circulation research 20100402
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Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100106
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Angiotensin II-induced oxidative stress resets the Ca2+ dependence of Ca2+-calmodulin protein kinase II and promotes a death pathway conserved across different species.
Circulation research 20091204
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Role of the AMPKgamma3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle.
American journal of physiology. Endocrinology and metabolism 20091201
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Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells.
Toxicology and applied pharmacology 20091101
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Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress.
American journal of physiology. Heart and circulatory physiology 20091101
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Phosphorylation alters the pharmacology of Ca(2+)-activated Cl channels in rabbit pulmonary arterial smooth muscle cells.
British journal of pharmacology 20091101
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Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure.
Circulation. Heart failure 20091101
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Acetylcholine rescues two-cell block through activation of IP3 receptors and Ca2+/calmodulin-dependent kinase II in an ICR mouse strain.
Pflugers Archiv : European journal of physiology 20091001
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Mg2+- and MgATP-inhibited and Ca2+/calmodulin-sensitive TRPM7-like current in hepatoma and hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology 20091001
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Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction.
Acta pharmacologica Sinica 20091001
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Calmodulin kinase II initiates arrhythmogenicity during metabolic acidification in murine hearts.
Acta physiologica (Oxford, England) 20090901
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Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.
Annals of the New York Academy of Sciences 20090901
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Pleiotropic effects of cadmium in mesangial cells.
Toxicology and applied pharmacology 20090801
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Substance P enhances excitatory synaptic transmission on spinally projecting neurons in the rostral ventromedial medulla after inflammatory injury.
Journal of neurophysiology 20090801
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Calcium/calmodulin-dependent protein kinase II mediates cardioprotection of intermittent hypoxia against ischemic-reperfusion-induced cardiac dysfunction.
American journal of physiology. Heart and circulatory physiology 20090801
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Oestrogen confers cardioprotection by suppressing Ca2+/calmodulin-dependent protein kinase II.
British journal of pharmacology 20090701
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Ca2+/calmodulin-dependent protein kinase II mediates apoptosis of P19 cells expressing human tau during neural differentiation with retinoic acid treatment.
Journal of enzyme inhibition and medicinal chemistry 20090401
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TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription.
American journal of physiology. Cell physiology 20090301
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miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2.
Circulation research 20090227
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Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII.
Neuron 20090212
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Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.
The Journal of biological chemistry 20090116
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Resynthesis of phosphatidylinositol 4,5-bisphosphate mediates adaptation of the caffeine response in rat taste receptor cells.
The Journal of physiology 20090115
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Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.
The Journal of biological chemistry 20090102
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Calcium/calmodulin-dependent kinase II regulates notch-1 signaling in prostate cancer cells.
Journal of cellular biochemistry 20090101
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Extracellular hypotonicity induces disturbance of sodium currents in rat ventricular myocytes.
Physiological research 20090101
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DY-9760e inhibits endothelin-1-induced cardiomyocyte hypertrophy through inhibition of CaMKII and ERK activities.
Cardiovascular therapeutics 20090101
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Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609).
Drug metabolism and disposition: the biological fate of chemicals 20081201
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Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II.
Journal of cellular physiology 20081101
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Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart.
Pflugers Archiv : European journal of physiology 20081101
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Nonclassical mechanisms of progesterone action in the brain: II. Role of calmodulin-dependent protein kinase II in progesterone-mediated signaling in the hypothalamus of female rats.
Endocrinology 20081101
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Inhibition of CaMKII in the nucleus accumbens shell decreases enhanced amphetamine intake in sensitized rats.
Neuroscience letters 20081024
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kappa-Opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - Role of CaMKIIdelta(B).
European journal of pharmacology 20081024
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Differential expression of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse hippocampus induced by various nociceptive stimuli.
Neuroscience 20081015
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Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
American journal of physiology. Heart and circulatory physiology 20081001
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Homocysteine activates calcium-mediated cell signaling mechanisms targeting the cytoskeleton in rat hippocampus.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20080801
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CaMK-II promotes focal adhesion turnover and cell motility by inducing tyrosine dephosphorylation of FAK and paxillin.
Cell motility and the cytoskeleton 20080801
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Cyclic adenosine 3',5'-monophosphate responsive element binding protein phosphorylation is required but not sufficient for activation of corticotropin-releasing hormone transcription.
Endocrinology 20080701
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A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils.
Experimental hematology 20080701
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Small-molecule activation of neuronal cell fate.
Nature chemical biology 20080701
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Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II.
The Biochemical journal 20080601
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Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2alpha (cPLA2alpha) by calmodulin-dependent protein kinase: possible interaction with catalytic domain A of cPLA2alpha.
Cellular signalling 20080501
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Identification of a molecular target for glutamate regulation of astrocyte water permeability.
Glia 20080415
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Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinase II.
The Journal of pharmacology and experimental therapeutics 20080401
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Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.
Circulation research 20080328
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Neuronal activity enhances aryl hydrocarbon receptor-mediated gene expression and dioxin neurotoxicity in cortical neurons.
Journal of neurochemistry 20080301
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Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway.
Molecular pharmacology 20080301
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CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking.
Nature neuroscience 20080301
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Role of Ca2+/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertension.
Cell biochemistry and function 20080101
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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Proceedings of the National Academy of Sciences of the United States of America 20071218
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Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.
Neuron 20071108
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Behavioral modulation of neuronal calcium/calmodulin-dependent protein kinase II activity: differential effects on nicotine-induced spinal and supraspinal antinociception in mice.
Biochemical pharmacology 20071015
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Calmodulin kinase II inhibition prevents arrhythmic activity induced by alpha and beta adrenergic agonists in rabbit pulmonary veins.
European journal of pharmacology 20071001
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Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL).
Journal of cellular physiology 20070901
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Separation of early afterdepolarizations from arrhythmogenic substrate in the isolated perfused hypokalaemic murine heart through modifiers of calcium homeostasis.
Acta physiologica (Oxford, England) 20070901
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Involvement of Ca(2+)/calmodulin-dependent protein kinases in mycelial growth of the basidiomycetous mushroom, Coprinus cinereus.
Biochimica et biophysica acta 20070901
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Ca2+/calmodulin kinase II increases ryanodine binding and Ca2+-induced sarcoplasmic reticulum Ca2+ release kinetics during beta-adrenergic stimulation.
Journal of molecular and cellular cardiology 20070901
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Roles of hippocampal N-methyl-D-aspartate receptors and calcium/calmodulin-dependent protein kinase II in amphetamine-produced conditioned place preference in rats.
Behavioural pharmacology 20070901
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Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells.
American journal of physiology. Cell physiology 20070701
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ANG II and calmodulin/CaMKII regulate surface expression and functional activity of NBCe1 via separate means.
American journal of physiology. Renal physiology 20070701
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Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.
Neuron 20070621
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iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle.
American journal of physiology. Heart and circulatory physiology 20070601
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Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction.
American journal of physiology. Endocrinology and metabolism 20070501
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W-7 modulates Kv4.3: pore block and Ca2+-calmodulin inhibition.
American journal of physiology. Heart and circulatory physiology 20070501
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Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival.
Cancer biology & therapy 20070501
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Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis.
The Journal of biological chemistry 20070406
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CaM kinase II activation and phospholamban phosphorylation by SNP in murine gastric antrum smooth muscles.
American journal of physiology. Gastrointestinal and liver physiology 20070401
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Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.
The Journal of biological chemistry 20070323
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Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II.
Molecular immunology 20070301
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Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism.
Molecular pharmacology 20070301
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CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury.
Cardiovascular research 20070301
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Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase.
Circulation research 20070216
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Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide.
Biological & pharmaceutical bulletin 20070201
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Uniaxial cyclic stretch-stimulated glucose transport is mediated by a ca-dependent mechanism in cultured skeletal muscle cells.
Pathobiology : journal of immunopathology, molecular and cellular biology 20070101
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Changes in subcellular distribution and phosphorylation of GluR1 in lesioned striatum of 6-hydroxydopamine-lesioned and l-dopa-treated rats.
Neurochemical research 20061101
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Calcium-calmodulin-dependent protein kinase II phosphorylation modulates PSD-95 binding to NMDA receptors.
The European journal of neuroscience 20061101
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Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.
Circulation 20060926
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Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases.
The Journal of endocrinology 20060901
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Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport.
Neuron 20060817
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CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels.
Biochemical and biophysical research communications 20060714
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Effects of protein kinase inhibitors on the in vitro growth of Babesia bovis.
Parasitology 20060601
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The regulation of calcium/calmodulin-dependent protein kinase II during oocyte activation in the rat.
The Journal of reproduction and development 20060601
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Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts.
The Biochemical journal 20060515
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Reversal of morphine antinociceptive tolerance and dependence by the acute supraspinal inhibition of Ca(2+)/calmodulin-dependent protein kinase II.
The Journal of pharmacology and experimental therapeutics 20060501
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KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels.
The Journal of pharmacology and experimental therapeutics 20060401
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Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatum.
European journal of pharmacology 20060327
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Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP.
American journal of physiology. Endocrinology and metabolism 20060301
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Calcium signaling stimulates translation of HIF-alpha during hypoxia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301
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Multiple, disparate roles for calcium signaling in apoptosis of human prostate and cervical cancer cells exposed to diindolylmethane.
Molecular cancer therapeutics 20060301
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Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20060208
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CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels.
Nature neuroscience 20060101
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Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells.
The Journal of endocrinology 20060101
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Developmental changes of CaMKII localization, activity and function during postembryonic CNS remodelling in Manduca sexta.
The European journal of neuroscience 20060101
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Molecular pathways leading to oxidative stress-induced phosphorylation of Akt.
Antioxidants & redox signaling 20060101
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Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.
Circulation research 20051209
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Modulation of intracellular Ca2+ release and capacitative Ca2+ entry by CaMKII inhibitors in bovine vascular endothelial cells.
American journal of physiology. Cell physiology 20051201
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NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII.
Neuron 20051020
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Membrane association of nitric oxide-sensitive guanylyl cyclase in cardiomyocytes.
Cardiovascular research 20051001
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Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery.
Pharmacological research 20050901
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Calcium/calmodulin-dependent kinase II mediates critical components of the hypoxic ventilatory response within the nucleus of the solitary tract in adult rats.
American journal of physiology. Regulatory, integrative and comparative physiology 20050901
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Ca2+/calmodulin-dependent protein kinase II is an essential mediator in the coordinated regulation of electrocyte Ca2+-ATPase by calmodulin and protein kinase A.
The Journal of biological chemistry 20050826
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Characterization of cAMP-dependent proteolysis of GATA-6.
Biochemical and biophysical research communications 20050715
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Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells.
Cancer research 20050615
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Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2).
European journal of pharmacology 20050601
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Increase of phosphorylation of calcium/calmodulin-dependent protein kinase-II in several brain regions by substance P administered intrathecally in mice.
Brain research bulletin 20050515
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Carboxy-terminal PTH fragments stimulate [3H]thymidine incorporation in vascular endothelial cells.
Peptides 20050501
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Galphaq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway.
Biochemical pharmacology 20050415
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Repeated administration of AMPA or a metabotropic glutamate receptor agonist into the rat ventral tegmental area augments the subsequent behavioral hyperactivity induced by cocaine.
Psychopharmacology 20050401
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Ca(2+)/calmodulin-protein kinase IIalpha in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection.
Experimental neurology 20050401
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Role of phosphorylation of Thr(17) residue of phospholamban in mechanical recovery during hypercapnic acidosis.
Cardiovascular research 20050401
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Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050323
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Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.
The Journal of biological chemistry 20050318
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Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia.
The Journal of biological chemistry 20050211
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CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy.
Biochemical and biophysical research communications 20050204
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Calcium/calmodulin dependent protein kinase II regulates the phosphorylation of cyclic AMP-responsive element-binding protein of spinal cord in rats following noxious stimulation.
Neuroscience letters 20050201
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Learning twice is different from learning once and from learning more.
Neuroscience 20050101
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Memory consolidation induces N-methyl-D-aspartic acid-receptor- and Ca2+/calmodulin-dependent protein kinase II-dependent modifications in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor properties.
Neuroscience 20050101
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Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor.
The Journal of biological chemistry 20041210
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In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons.
Pain 20041201
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The role of calcium/calmodulin-dependent protein kinase II on the inactivation of MAP kinase and p34cdc2 kinase during fertilization and activation in pig oocytes.
Reproduction (Cambridge, England) 20041001
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Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20040922
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NMDA receptors and associated signaling pathways: a role in knee joint blood flow regulation.
European journal of pharmacology 20040919
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A CaMKII/calcineurin switch controls the direction of Ca(2+)-dependent growth cone guidance.
Neuron 20040916
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Effect of angiotensin II type 1 receptor on delayed rectifier potassium current in catecholaminergic CATH.a cells.
Acta pharmacologica Sinica 20040901
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Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter.
FEBS letters 20040702
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Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20040609
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Sustained potentiation by substance P of NMDA-activated current in rat primary sensory neurons.
Brain research 20040604
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Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei.
Neurochemistry international 20040601
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Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.
The Journal of biological chemistry 20040409
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Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons.
Neuron 20040408
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Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.
Circulation research 20040402
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Mechanisms of action of melanin-concentrating hormone in the teleost fish erythrophoroma cell line (GEM-81).
General and comparative endocrinology 20040401
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Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.
Journal of cellular biochemistry 20040401
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Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells.
Archives of biochemistry and biophysics 20040315
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Roles of CaMKII, PKA, and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn.
Journal of neurophysiology 20040301
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The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production.
Molecular endocrinology (Baltimore, Md.) 20040201
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Protein kinase A and calcium/calmodulin-dependent protein kinase II regulate glycine and GABA release in auditory brain stem nuclei.
Journal of neuroscience research 20040201
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Alpha-keto-beta-methylvaleric acid increases the in vitro phosphorylation of intermediate filaments in cerebral cortex of young rats through the gabaergic system.
Journal of the neurological sciences 20040115
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Suppressing calcium/calmodulin-dependent protein kinase II activity in the ventral tegmental area enhances the acute behavioural response to cocaine but attenuates the initiation of cocaine-induced behavioural sensitization in rats.
The European journal of neuroscience 20040101
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Phospholamban is required for CaMKII-dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytes.
Journal of molecular and cellular cardiology 20040101
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Role of the calcium/calmodulin-dependent protein kinase ii (CaMKII) in the morphine-induced pharmacological effects in the mouse.
Neuroscience 20040101
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CaM kinase II regulation of CRHSP-28 phosphorylation in cultured mucosal T84 cells.
American journal of physiology. Gastrointestinal and liver physiology 20031201
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CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction.
The Journal of biological chemistry 20031107
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Trans-cellular proliferating cell nuclear antigen gene activation in cerebral vascular smooth muscle by endothelial oxidative injury in vivo.
Arteriosclerosis, thrombosis, and vascular biology 20031101
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Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid.
American journal of physiology. Endocrinology and metabolism 20030801
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The involvement of calcineurin in acetylcholine receptor redistribution in muscle.
Molecular and cellular neurosciences 20030801
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Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization.
Journal of immunology (Baltimore, Md. : 1950) 20030715
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Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.
American journal of physiology. Cell physiology 20030701
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Involvement of Ca2+/calmodulin-dependent protein kinase II in endothelial NO production and endothelium-dependent relaxation.
American journal of physiology. Heart and circulatory physiology 20030601
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The calcium component of gonadotropin-releasing hormone-stimulated luteinizing hormone subunit gene transcription is mediated by calcium/calmodulin-dependent protein kinase type II.
Endocrinology 20030601
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Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release.
Circulation research 20030502
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Calcium-dependent, D2 receptor-independent induction of c-fos by haloperidol in dopamine neurons.
Naunyn-Schmiedeberg's archives of pharmacology 20030501
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Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401
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Reversal of morphine antinociceptive tolerance by acute spinal inhibition of Ca(2+)/calmodulin-dependent protein kinase II.
European journal of pharmacology 20030328
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Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice.
European journal of pharmacology 20030319
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Calcium/calmodulin-dependent kinase II is involved in the facilitating effect of clozapine on NMDA- and electrically evoked responses in the medial prefrontal cortical pyramidal cells.
Synapse (New York, N.Y.) 20030315
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Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon.
Life sciences 20030314
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Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.
Journal of neurophysiology 20030301
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Cellular mechanisms of the acute increase of glutamate release induced by nerve growth factor in rat cerebral cortex.
Neuropharmacology 20030301
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Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells.
The Journal of biological chemistry 20030227
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Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger.
Biochimica et biophysica acta 20030217
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Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization.
Brain research 20030207
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Modulation of the hyperpolarization-activated current (I(f)) by calcium and calmodulin in the guinea-pig sino-atrial node.
Cardiovascular research 20030201
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Ca2+/calmodulin-dependent protein kinase II stimulates c-fos transcription and DNA synthesis by a Src-based mechanism in glomerular mesangial cells.
Journal of the American Society of Nephrology : JASN 20030101
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Degranulation in RBL-2H3 cells: regulation by calmodulin pathway.
Cell biology international 20030101
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Early pathophysiological changes in cerebral vessels predisposing to stroke.
Clinical hemorheology and microcirculation 20030101
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Differential autophosphorylation of CaM kinase II from phasic and tonic smooth muscle tissues.
American journal of physiology. Cell physiology 20021101
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Activation of extracellular-regulated kinase by 5-hydroxytryptamine(2A) receptors in PC12 cells is protein kinase C-independent and requires calmodulin and tyrosine kinases.
The Journal of pharmacology and experimental therapeutics 20021101
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Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism.
The Journal of biological chemistry 20020920
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Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy.
Circulation 20020903
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Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase.
Endocrinology 20020901
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Phosphorylation of neuronal nitric oxide synthase at Ser847 by CaM-KII in the hippocampus of rat brain after transient forebrain ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020901
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Lack of PSD-95 drives hippocampal neuronal cell death through activation of an alpha CaMKII transduction pathway.
The European journal of neuroscience 20020901
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Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
The Journal of endocrinology 20020801
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Regulation of CDPKs, including identification of PAL kinase, in biotically stressed cells of French bean.
Plant molecular biology 20020701
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Ca(2+)-calmodulin-dependent protein kinase II plays a major role in halothane-induced dose-dependent relaxation in the skinned pulmonary artery.
Anesthesiology 20020701
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Co-requirement of cyclic AMP- and calcium-dependent protein kinases for transcriptional activation of cholecystokinin gene by protein hydrolysates.
The Journal of biological chemistry 20020621
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Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20020515
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CaM kinase II-dependent activation of tyrosine kinases and ERK1/2 in vascular smooth muscle.
American journal of physiology. Cell physiology 20020401
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Phase I and phase II of short-term mechanical restitution in perfused rat left ventricles.
American journal of physiology. Heart and circulatory physiology 20020401
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Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240.
The Biochemical journal 20020315
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Impairing the amphetamine conditioning in rats through the inhibition of hippocampal calcium/calmodulin-dependent protein kinase II activity.
Neuropharmacology 20020301
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Dual effect of blocking agents on Ca2+-activated Cl(-) currents in rabbit pulmonary artery smooth muscle cells.
The Journal of physiology 20020215
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myo-Inositol 1,4,5-trisphosphate and Ca(2+)/calmodulin-dependent factors mediate transduction of compression-induced signals in bovine articular chondrocytes.
The Biochemical journal 20020201
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Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound.
Journal of medicinal chemistry 20020131
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The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway.
Brain research. Molecular brain research 20020131
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Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected].
Peptides 20020101
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Angiotensin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mechanism.
Journal of neurochemistry 20011201
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Different subtypes of alpha1-adrenoceptor modulate different K+ currents via different signaling pathways in canine ventricular myocytes.
The Journal of biological chemistry 20011102
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PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation.
British journal of pharmacology 20011101
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Nicotine-induced phosphorylation of extracellular signal-regulated protein kinase and CREB in PC12h cells.
Journal of neurochemistry 20011101
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Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.
Toxicology 20011015
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Essential role for extracellular Ca(2+) in JNK activation by mechanical stretch in bladder smooth muscle cells.
American journal of physiology. Cell physiology 20011001
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Activation of p42/p44 mitogen-activated protein kinase and contraction by prostaglandin F2alpha, ionomycin, and thapsigargin in cat iris sphincter smooth muscle: inhibition by PD98059, KN-93, and isoproterenol.
The Journal of pharmacology and experimental therapeutics 20011001
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The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC.
Journal of cell science 20011001
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Ca2+/calmodulin-dependent protein kinase II and cytosolic phospholipase A2 contribute to mitogenic signaling in myeloblastic leukemia U-937 cells.
The Journal of pharmacology and experimental therapeutics 20010701
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Compensatory role of CaMKII on ICa and SR function during acidosis in rat ventricular myocytes.
Pflugers Archiv : European journal of physiology 20010601
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Phospholipase D activation by norepinephrine is mediated by 12(s)-, 15(s)-, and 20-hydroxyeicosatetraenoic acids generated by stimulation of cytosolic phospholipase a2. tyrosine phosphorylation of phospholipase d2 in response to norepinephrine.
The Journal of biological chemistry 20010511
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Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors.
Experimental hematology 20010501
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The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway.
The Journal of biological chemistry 20010427
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KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser.
Molecular and cellular endocrinology 20010425
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Ca2+ mediates the effect of inhibition of Na+-K+-ATPase on the basolateral K+ channels in the rat CCD.
American journal of physiology. Cell physiology 20010401
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Calcium/calmodulin-dependent protein kinase inhibition potentiates thapsigargin-mediated cell death in SH-SY5Y human neuroblastoma cells.
Neuroscience letters 20010330
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Regulation of InsP3-mediated Ca2+ release by CaMKII in Xenopus oocytes.
Pflugers Archiv : European journal of physiology 20010301
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Calcium-mediated second messengers modulate the expression of behavioral sensitization to cocaine.
The Journal of pharmacology and experimental therapeutics 19980901
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The novel insulinotropic mechanism of pimobendan: direct enhancement of the exocytotic process of insulin secretory granules by increased Ca2+ sensitivity in beta-cells.
Endocrinology 19980301
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The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells.
Biochemical and biophysical research communications 19911231