139404-48-1 | Tiotropium bromide hydrate

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$201.00	$141.00
1g	97%	in stock	$712.00	$498.00
5g	97%	in stock	$2,460.00	$1,722.00

Description

• Catalog Number: AA60666
• Chemical Name: Tiotropium bromide hydrate
• CAS Number: 139404-48-1
• Molecular Formula: C19H24BrNO5S2
• Molecular Weight: 490.4316
• MDL Number: MFCD08141831
• SMILES: O=C(C(c1cccs1)(c1cccs1)O)OC1CC2C3C(C(C1)[N+]2(C)C)O3.[Br-].O

Computed Properties

• Complexity: 564
• Covalently-Bonded Unit Count: 3
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 5

Literature

• Comparing the cardiovascular therapeutic indices of glycopyrronium and tiotropium in an integrated rat pharmacokinetic, pharmacodynamic and safety model.

  Toxicology and applied pharmacology 20150815

• Olodaterol: first global approval.

  Drugs 20131101

• Aclidinium bromide for the treatment of chronic obstructive pulmonary disease.

  Expert opinion on pharmacotherapy 20130601

• Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases.

  The Journal of pharmacology and experimental therapeutics 20130501

• Tiotropium increases PPARγ and decreases CREB in cells isolated from induced sputum of COPD patients.

  Advances in experimental medicine and biology 20130101

• Effect of device design on the in vitro performance and comparability for capsule-based dry powder inhalers.

  The AAPS journal 20121201

• Cost-utility analysis of tiotropium versus usual care in patients with COPD in the UK and Belgium.

  Respiratory medicine 20121201

• Detrended fluctuation analysis of peak expiratory flow and exacerbation frequency in COPD.

  The European respiratory journal 20121101

• The Influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium.

  The Journal of pharmacology and experimental therapeutics 20121101

• Efficacy and safety of NVA237 versus placebo and tiotropium in patients with COPD: the GLOW2 study.

  The European respiratory journal 20121101

• Probing biochemical mechanisms of action of muscarinic M3 receptor antagonists with label-free whole cell assays.

  Analytical chemistry 20121002

• Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol.

  British journal of pharmacology 20121001

• Bronchodilators modulate inflammation in chronic obstructive pulmonary disease subjects.

  Pharmacological research 20121001

• Addition of tiotropium to formoterol improves inspiratory muscle strength after exercise in COPD.

  Respiratory medicine 20121001

• Effect of combination treatment on lung volumes and exercise endurance time in COPD.

  Respiratory medicine 20121001

• [Early treatment of COPD with tiotropium].

  Pneumologie (Stuttgart, Germany) 20121001

• Which long-acting bronchodilator is most cost-effective for the treatment of COPD?

  The Netherlands journal of medicine 20121001

• Tiotropium in asthma poorly controlled with standard combination therapy.

  The New England journal of medicine 20120927

• Tiotropium for asthma--promise and caution.

  The New England journal of medicine 20120927

• Tiotropium versus long-acting beta-agonists for stable chronic obstructive pulmonary disease.

  The Cochrane database of systematic reviews 20120912

• Concurrent use of indacaterol plus tiotropium in patients with COPD provides superior bronchodilation compared with tiotropium alone: a randomised, double-blind comparison.

  Thorax 20120901

• Computed tomography assessment of pharmacological lung volume reduction induced by bronchodilators in COPD.

  COPD 20120801

• Four-year trial of tiotropium in chronic obstructive pulmonary disease.

  Canadian family physician Medecin de famille canadien 20120801

• Tiotropium versus placebo for chronic obstructive pulmonary disease.

  The Cochrane database of systematic reviews 20120711

• Inhibitory effects of tiotropium on rhinovirus infection in human airway epithelial cells.

  The European respiratory journal 20120701

• β₂ long-acting and anticholinergic drugs control TGF-β1-mediated neutrophilic inflammation in COPD.

  Biochimica et biophysica acta 20120701

• Effect of tiotropium bromide on airway remodeling in a chronic asthma model.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20120701

• Rehospitalization risks and outcomes in COPD patients receiving maintenance pharmacotherapy.

  Respiratory medicine 20120601

• Efficacy of tiotropium in COPD patients with FEV1 ≥ 60% participating in the UPLIFT® trial.

  COPD 20120601

• Key observations from the NHLBI Asthma Clinical Research Network.

  Thorax 20120501

• Cause-specific mortality adjudication in the UPLIFT® COPD trial: findings and recommendations.

  Respiratory medicine 20120401

• Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: a pilot study.

  Therapeutic advances in respiratory disease 20120401

• A randomised, placebo-controlled, dose-finding study of AZD9668, an oral inhibitor of neutrophil elastase, in patients with chronic obstructive pulmonary disease treated with tiotropium.

  COPD 20120401

• In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD.

  Immunobiology 20120301

• Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma.

  British journal of pharmacology 20120301

• Efficacy of aclidinium bromide 400 μg twice daily compared with placebo and tiotropium in patients with moderate to severe COPD.

  Chest 20120301

• Comparison of tiotropium plus fluticasone propionate/salmeterol with tiotropium in COPD: a randomized controlled study.

  Respiratory medicine 20120301

• Tiotropium: what came after the UPLIFT study.

  Expert opinion on pharmacotherapy 20120301

• Structure and dynamics of the M3 muscarinic acetylcholine receptor.

  Nature 20120223

• Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile.

  Life sciences 20120213

• Pharmacoeconomic evaluation of tiotropium bromide in the long-term treatment of chronic obstructive pulmonary disease (COPD) in Italy.

  The European journal of health economics : HEPAC : health economics in prevention and care 20120201

• Tiotropium improves walking endurance in COPD.

  The European respiratory journal 20120201

• Tiotropium Handihaler and the risk of cardio- or cerebrovascular events and mortality in patients with COPD.

  Pulmonary pharmacology & therapeutics 20120201

• Comparison of three combined pharmacological approaches with tiotropium monotherapy in stable moderate to severe COPD: a systematic review.

  Pulmonary pharmacology & therapeutics 20120201

• Demographic, physiologic and radiographic characteristics of COPD patients taking chronic systemic corticosteroids.

  COPD 20120201

• PURLs: would this long-acting bronchodilator be better for your patient?

  The Journal of family practice 20120201

• Tiotropium bromide inhalation powder: a review of its use in the management of chronic obstructive pulmonary disease.

  Drugs 20120122

• The impact of tiotropium on mortality and exacerbations when added to inhaled corticosteroids and long-acting β-agonist therapy in COPD.

  Chest 20120101

• Acute effects of indacaterol on lung hyperinflation in moderate COPD: a comparison with tiotropium.

  Respiratory medicine 20120101

• Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD.

  Respiratory medicine 20120101

• Assessment of combined muscarinic antagonist and fibrinolytic therapy for inhalation injury.

  Journal of burn care & research : official publication of the American Burn Association 20120101

• Observational study on the impact of initiating tiotropium alone versus tiotropium with fluticasone propionate/salmeterol combination therapy on outcomes and costs in chronic obstructive pulmonary disease.

  Respiratory research 20120101

• Safety and efficacy of dual therapy with GSK233705 and salmeterol versus monotherapy with salmeterol, tiotropium, or placebo in a crossover pilot study in partially reversible COPD patients.

  International journal of chronic obstructive pulmonary disease 20120101

• Comparative health-care cost advantage of ipratropium over tiotropium in COPD patients.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20120101

• Clinical and economic outcomes in an observational study of COPD maintenance therapies: multivariable regression versus propensity score matching.

  International journal of chronic obstructive pulmonary disease 20120101

• Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease.

  The Cochrane database of systematic reviews 20120101

• [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD)].

  Pneumonologia i alergologia polska 20120101

• Effects of tiotropium on sympathetic activation during exercise in stable chronic obstructive pulmonary disease patients.

  International journal of chronic obstructive pulmonary disease 20120101

• Clinical trial design in chronic obstructive pulmonary disease: current perspectives and considerations with regard to blinding of tiotropium.

  Respiratory research 20120101

• [A pharmacovigilance study in chest diseases outpatient clinic].

  Tuberkuloz ve toraks 20120101

• Effects of inhaled tiotropium on left ventricular diastolic function in chronic obstructive pulmonary disease patients after pulmonary resection.

  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20120101

• Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease.

  Respiratory research 20120101

• Exacerbation frequency and course of COPD.

  International journal of chronic obstructive pulmonary disease 20120101

• Factors associated with misdiagnosis of COPD in primary care.

  Primary care respiratory journal : journal of the General Practice Airways Group 20111201

• [Prevention in chronic obstructive pulmonary disease. POET-COPD (prevention of exacerbations with tiotropium in COPD)].

  Der Internist 20111201

• Application of latent growth and growth mixture modeling to identify and characterize differential responders to treatment for COPD.

  Contemporary clinical trials 20111101

• Cost-utility analysis of indacaterol in Germany: a once-daily maintenance bronchodilator for patients with COPD.

  Respiratory medicine 20111101

• [Theoretical and clinical aspects of tiotropium application as a first line therapy in stable state of all stages of chronic obstructive pulmonary disease].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20111101

• [The curative effect of Fluticasone Salmeterol combined with Tiotropium Bromide for silicosis].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20111101

• Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.

  Journal of medicinal chemistry 20111013

• Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD.

  The European respiratory journal 20111001

• Premature discontinuation during the UPLIFT study.

  Respiratory medicine 20111001

• Blinded 12-week comparison of once-daily indacaterol and tiotropium in COPD.

  The European respiratory journal 20111001

• Effects of inhaled tiotropium plus transdermal tulobuterol versus tiotropium alone on impulse oscillation system (IOS)-assessed measures of peripheral airway resistance and reactance, lung function and quality of life in patients with COPD: a randomized crossover study.

  Pulmonary pharmacology & therapeutics 20111001

• Comparative study on the efficacy of tiotropium bromide inhalation and oral doxofylline treatment of moderate to severe stable chronic obstructive pulmonary disease.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20111001

• [Evidence of pharmacotherapy in COPD--key findings from recently-conducted randomized clinical studies].

  Nihon rinsho. Japanese journal of clinical medicine 20111001

• Centrilobular opacities in the asthmatic lung successfully treated with inhaled ciclesonide and tiotropium: with assessment of alveolar nitric oxide levels.

  Allergology international : official journal of the Japanese Society of Allergology 20110901

• Improved respiratory system conductance following bronchodilator predicts reduced exertional dyspnoea.

  Respiratory medicine 20110901

• Changes of clinical outcomes and health care resources in moderate and in severe COPD treated uniquely with tiotropium 18 mcg od for twenty-four months.

  Pulmonary pharmacology & therapeutics 20110801

• Chronic obstructive pulmonary disease megatrials: taking the results into office practice.

  The American journal of the medical sciences 20110801

• Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial.

  The Journal of allergy and clinical immunology 20110801

• Risk of nonlower respiratory serious adverse events following COPD exacerbations in the 4-year UPLIFT® trial.

  Lung 20110801

• Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma.

  The Journal of allergy and clinical immunology 20110801

• Effect of tiotropium bromide on expression of CD(8) (+)CD (25) (+)FoxP (3) (+) regulatory T cells in patients with stable chronic obstructive pulmonary disease.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20110801

• Outcomes and costs associated with initial maintenance therapy with fluticasone propionate-salmeterol xinafoate 250 microg/50 microg combination versus tiotropium in commercially insured patients with COPD.

  Managed care (Langhorne, Pa.) 20110801

• Another plausible explanation for mist inhaler's toxicity.

  BMJ (Clinical research ed.) 20110725

• Efficacy of tiotropium in COPD patients from Asia: a subgroup analysis from the UPLIFT trial.

  Respirology (Carlton, Vic.) 20110701

• The epidemiology and type of medication errors reported to the National Poisons Information Centre of Ireland.

  Clinical toxicology (Philadelphia, Pa.) 20110701

• Tiotropium versus salmeterol in COPD.

  The New England journal of medicine 20110630

• Tiotropium versus salmeterol in COPD.

  The New England journal of medicine 20110630

• Tiotropium versus salmeterol in COPD.

  The New England journal of medicine 20110630

• Tiotropium versus salmeterol in COPD.

  The New England journal of medicine 20110630

• Spiriva (Respimat) increases mortality by 52% in patients with COPD: time to take action.

  The New Zealand medical journal 20110624

• Safety of tiotropium.

  BMJ (Clinical research ed.) 20110614

• Short-term effects of inhalative tiotropium/formoterol/budenoside versus tiotropium/formoterol in patients with newly diagnosed chronic obstructive pulmonary disease requiring surgery for lung cancer: a prospective randomized trial.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20110601

• Effects of formoterol and tiotropium bromide on mucus clearance in patients with COPD.

  Respiratory medicine 20110601

• NVA237, a long-acting muscarinic antagonist, as an emerging therapy for chronic obstructive pulmonary disease.

  Therapeutic advances in respiratory disease 20110601

• Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.

  Bioorganic & medicinal chemistry letters 20110601

• Trends in health care utilization in British Columbia following public coverage for tiotropium.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20110601

• Triple inhalers for obstructive airways disease: will they be useful?

  Expert review of respiratory medicine 20110601

• Inhaled anticholinergic drug therapy and the risk of acute urinary retention in chronic obstructive pulmonary disease: a population-based study.

  Archives of internal medicine 20110523

• Inhaled anticholinergics for chronic obstructive pulmonary disease: comment on 'Inhaled anticholinergic drug therapy and the risk of acute urinary retention in chronic obstructive pulmonary disease'.

  Archives of internal medicine 20110523

• Lack of protective effect of tiotropium vs induced dynamic hyperinflation in moderate COPD.

  Respiratory medicine 20110501

• Cost effectiveness of budesonide/formoterol added to tiotropium bromide versus placebo added to tiotropium bromide in patients with chronic obstructive pulmonary disease: Australian, Canadian and Swedish healthcare perspectives.

  PharmacoEconomics 20110501

• Inhaled anticholinergic drugs and risk of acute urinary retention.

  BJU international 20110401

• Cardio- and cerebrovascular safety of indacaterol vs formoterol, salmeterol, tiotropium and placebo in COPD.

  Respiratory medicine 20110401

• Tiotropium for treatment of stable COPD: a meta-analysis of clinically relevant outcomes.

  Respiratory care 20110401

• Tiotropium versus salmeterol for the prevention of exacerbations of COPD.

  The New England journal of medicine 20110324

• Choice of bronchodilator therapy for patients with COPD.

  The New England journal of medicine 20110324

• Reported pneumonia in patients with COPD: findings from the INSPIRE study.

  Chest 20110301

• Acute bronchodilator responsiveness in bronchiolitis obliterans syndrome following hematopoietic stem cell transplantation.

  Chest 20110301

• Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules.

  Bioorganic & medicinal chemistry letters 20110301

• [Phosphodiesterase-4 inhibitors: roflumilast].

  Revista clinica espanola 20110301

• Tiotropium step-up therapy in asthma.

  The New England journal of medicine 20110210

• Tiotropium step-up therapy in asthma.

  The New England journal of medicine 20110210

• Combined treatment with formoterol and tiotropium is more efficacious than treatment with tiotropium alone in patients with chronic obstructive pulmonary disease, regardless of smoking status, inhaled corticosteroid use, baseline severity, or gender.

  Pulmonary pharmacology & therapeutics 20110201

• Comparison of tiotropium plus formoterol to tiotropium alone in stable chronic obstructive pulmonary disease: a meta-analysis.

  Respirology (Carlton, Vic.) 20110201

• [Pathogenesis, diagnosis and therapy of bronchial asthma. How can the lungs be freed?].

  MMW Fortschritte der Medizin 20110127

• Effects of adding salmeterol/fluticasone propionate to tiotropium on airway dimensions in patients with chronic obstructive pulmonary disease.

  Respirology (Carlton, Vic.) 20110101

• Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans.

  Drug metabolism and disposition: the biological fate of chemicals 20110101

• Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial.

  Respiratory research 20110101

• Community pharmacy and pharmacist staff call center: assessment of medication safety and effectiveness.

  Journal of the American Pharmacists Association : JAPhA 20110101

• Respiratory-related medical expenditure and inpatient utilisation among COPD patients receiving long-acting bronchodilator therapy.

  Journal of medical economics 20110101

• Comparative cost-effectiveness of a fluticasone-propionate/salmeterol combination versus anticholinergics as initial maintenance therapy for chronic obstructive pulmonary disease.

  International journal of chronic obstructive pulmonary disease 20110101

• Inhibition of granulocyte migration by tiotropium bromide.

  Respiratory research 20110101

• Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate.

  Journal of pharmacological sciences 20110101

• Anticholinergics may play more roles in chronic obstructive pulmonary disease.

  Chinese medical journal 20110101

• Combination inhaled steroid and long-acting beta(2)-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease.

  The Cochrane database of systematic reviews 20110101

• [The verge and the abyss: tiotropium (Spiriva) in COPD].

  Harefuah 20110101

• Comparison of efficacy of long-acting bronchodilators in emphysema dominant and emphysema nondominant chronic obstructive pulmonary disease.

  International journal of chronic obstructive pulmonary disease 20110101

• Bronchodilation improves endurance but not muscular efficiency in chronic obstructive pulmonary disease.

  International journal of chronic obstructive pulmonary disease 20110101

• Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials.

  BMJ (Clinical research ed.) 20110101

• [Determination of clinical phenotypes of chronic obstructive pulmonary disease--a new treatment approach].

  Terapevticheskii arkhiv 20110101

• Delivery characteristics and patients' handling of two single-dose dry-powder inhalers used in COPD.

  International journal of chronic obstructive pulmonary disease 20110101

• Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD.

  International journal of chronic obstructive pulmonary disease 20110101

• Tiotropium reduces risk of exacerbations irrespective of previous use of inhaled anticholinergics in placebo-controlled clinical trials.

  International journal of chronic obstructive pulmonary disease 20110101

• The effect of adding inhaled corticosteroids to tiotropium and long-acting beta(2)-agonists for chronic obstructive pulmonary disease.

  The Cochrane database of systematic reviews 20110101

• Adverse health consequences in COPD patients with rapid decline in FEV1--evidence from the UPLIFT trial.

  Respiratory research 20110101

• Cost-effectiveness analysis of roflumilast/tiotropium therapy versus tiotropium monotherapy for treating severe-to-very severe COPD.

  Journal of medical economics 20110101

• Suppression of IL-8 production from airway cells by tiotropium bromide in vitro.

  International journal of chronic obstructive pulmonary disease 20110101

• The discovery of new spirocyclic muscarinic M3 antagonists.

  Bioorganic & medicinal chemistry letters 20101215

• Bronchodilator activity of (3R)-3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino] carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1-azoniabicyclo[2.2.2]octane bromide (CHF5407), a potent, long-acting, and selective muscarinic M3 receptor antagonist.

  The Journal of pharmacology and experimental therapeutics 20101201

• Muscarinic receptor antagonist therapy improves acute pulmonary dysfunction after smoke inhalation injury in sheep.

  Critical care medicine 20101201

• Effect of tiotropium on quality of life in COPD: a systematic review.

  Primary care respiratory journal : journal of the General Practice Airways Group 20101201

• [Clinical profile of roflumilast].

  Archivos de bronconeumologia 20101201

• COPD in young patients: a pre-specified analysis of the four-year trial of tiotropium (UPLIFT).

  Respiratory medicine 20101101

• [Tiotropium bromide for treating chronic obstructive pulmonary disease].

  Eksperimental'naia i klinicheskaia farmakologiia 20101101

• Tiotropium bromide step-up therapy for adults with uncontrolled asthma.

  The New England journal of medicine 20101028

• Products at risk.

  The New England journal of medicine 20101028

• Anticholinergics for patients with asthma?

  The New England journal of medicine 20101028

• Effect of tiotropium in men and women with COPD: results of the 4-year UPLIFT trial.

  Respiratory medicine 20101001

• Energy expenditure and impact of bronchodilators in COPD patients.

  Respiratory medicine 20101001

• Sustained 24-h efficacy of NVA237, a once-daily long-acting muscarinic antagonist, in COPD patients.

  Respiratory medicine 20101001

• A one-year trial of tiotropium Respimat plus usual therapy in COPD patients.

  Respiratory medicine 20101001

• Adherence to controller therapy for chronic obstructive pulmonary disease: a review.

  Current medical research and opinion 20101001

• Onset of effect of aclidinium, a novel, long-acting muscarinic antagonist, in patients with COPD.

  COPD 20101001

• Pooled studies can raise misleading alarm bells, regulators say.

  Nature medicine 20101001

• Meta-analysis and moderation.

  Nature reviews. Drug discovery 20101001

• The safety of tiotropium--the FDA's conclusions.

  The New England journal of medicine 20100916

• Paradoxical trough effects of triple therapy with budesonide/formoterol and tiotropium bromide on pulmonary function outcomes in COPD.

  Chest 20100901

• The cardiovascular risk of tiotropium: is it real?

  Expert opinion on drug safety 20100901

• Effects of tiotropium and formoterol on dynamic hyperinflation and exercise endurance in COPD.

  Respiratory medicine 20100901

• Comment on tiotropium.

  Respiratory medicine 20100901

• [Experimental inhalation therapy with nebulized tiotropium in COPD patients unable to use the Handihaler].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20100901

• Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20100801

• Tiotropium bromide exerts anti-inflammatory activity in a cigarette smoke mouse model of COPD.

  Pulmonary pharmacology & therapeutics 20100801

• Outpatient management of severe COPD.

  The New England journal of medicine 20100729

• Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium.

  American journal of respiratory and critical care medicine 20100715

• Tiotropium as a first maintenance drug in COPD: secondary analysis of the UPLIFT trial.

  The European respiratory journal 20100701

• Combining tiotropium and salmeterol in COPD: Effects on airflow obstruction and symptoms.

  Respiratory medicine 20100701

• Family increases: UPLIFT first maintenance subgroup analysis.

  The European respiratory journal 20100701

• Complete smoking cessation is beneficial in older and more advanced COPD patients.

  The European respiratory journal 20100701

• [A randomized, double-blind, placebo-control study of once-daily inhaled tiotropium in chronic obstructive pulmonary disease].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20100701

• Tiotropium reduction of lung inflammation in a model of chronic gastro-oesophageal reflux.

  The European respiratory journal 20100601

• Integrating indacaterol dose selection in a clinical study in COPD using an adaptive seamless design.

  Pulmonary pharmacology & therapeutics 20100601

• Tiotropium therapy and mortality risk in COPD patients: the most severe, the most protected? Evaluation of Celli B, Decramer M, Kesten S, et al. Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009; 180(10): 948-55.

  Expert opinion on pharmacotherapy 20100601

• Impact of tiotropium on the course of moderate-to-very severe chronic obstructive pulmonary disease: the UPLIFT trial.

  Expert review of respiratory medicine 20100601

• Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease.

  The Cochrane database of systematic reviews 20100512

• [Safety of tiotropium therapy in chronic obstructive lung diseases (COPD)].

  Orvosi hetilap 20100502

• Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice.

  The European respiratory journal 20100501

• [Therapeutic effect of tiotropium bromide powder inhalation in patients with stable bronchiectasis].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100501

• Essential tactics of tissue preparation and matrix nano-spotting for successful compound imaging mass spectrometry.

  Journal of proteomics 20100418

• New evidence in pulmonary and preventive medicine.

  Internal and emergency medicine 20100401

• Combining triple therapy and pulmonary rehabilitation in patients with advanced COPD: a pilot study.

  Respiratory medicine 20100301

• Effects of inhaled therapy on biomarkers of systemic inflammation in stable chronic obstructive pulmonary disease.

  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20100301

• Long-acting anticholinergic use in chronic obstructive pulmonary disease: efficacy and safety.

  Current opinion in pulmonary medicine 20100301

• Economic analyses comparing tiotropium with ipratropium or salmeterol in UK patients with COPD.

  Primary care respiratory journal : journal of the General Practice Airways Group 20100301

• Tiotropium and chronic obstructive pulmonary disease.

  BMJ (Clinical research ed.) 20100219

• Long-term efficacy of tiotropium in relation to smoking status in the UPLIFT trial.

  The European respiratory journal 20100201

• Additive effects of transdermal tulobuterol to inhaled tiotropium in patients with COPD.

  Respiratory medicine 20100201

• Tiotropium 5microg via Respimat and 18microg via HandiHaler; efficacy and safety in Japanese COPD patients.

  Respiratory medicine 20100201

• Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption.

  Molecular pharmaceutics 20100201

• Potential for long-acting muscarinic antagonists in chronic obstructive pulmonary disease.

  Expert opinion on investigational drugs 20100201

• Role of inhaled tiotropium on the perioperative outcomes of patients with lung cancer and chronic obstructive pulmonary disease.

  The Thoracic and cardiovascular surgeon 20100201

• Accidental overdose of tiotropium in a patient with atrial fibrillation.

  The Annals of pharmacotherapy 20100201

• [Debates surrounding COPD].

  Revue des maladies respiratoires 20100201

• [Long-term trials assessing pharmacological treatments in COPD: lessons and limitations].

  Revue des maladies respiratoires 20100201

• How much lift to the UPLIFT study?

  Lancet (London, England) 20100116

• Cardiovascular safety of tiotropium in patients with COPD.

  Chest 20100101

• [Muscarinic cholinergic receptor antagonists enhanced the expression of CD(8)(+)CD(25)(+)Foxp(3)(+) regulatory T cells in stable COPD patients].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20100101

• Preventing and managing exacerbations in COPD--critical appraisal of the role of tiotropium.

  International journal of chronic obstructive pulmonary disease 20100101

• [Short-term effect of tiotropium in COPD patients being treated with a beta2 agonist].

  Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 20100101

• Pharmacological studies of bronchial constriction inhibited by parasympatholytics and cilomilast using equine precision-cut lung slices.

  Berliner und Munchener tierarztliche Wochenschrift 20100101

• Cost effectiveness of tiotropium for chronic obstructive pulmonary disease: a systematic review of the evidence.

  Journal of medical economics 20100101

• Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry.

  PloS one 20100101

• Comparison of risk of neurovascular and cardiovascular side effects between tiotropium and other anticholinergic agents.

  Quality in primary care 20100101

• [Anticholinergics and their cardiovascular effects--between fear and reality].

  Pneumologia (Bucharest, Romania) 20100101

• Efficacy and safety of tiotropium Respimat SMI in COPD in two 1-year randomized studies.

  International journal of chronic obstructive pulmonary disease 20100101

• Do we need different treatments for very elderly COPD patients?

  Respiration; international review of thoracic diseases 20100101

• Tiotropium's cost-effectiveness for the treatment of COPD: a cost-utility analysis under real-world conditions.

  BMC pulmonary medicine 20100101

• 'Show me the money': a fair criticism of economic studies on inhaled bronchodilators for COPD.

  BMC pulmonary medicine 20100101

• Tiotropium bromide inhibits TGF-β-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro.

  International journal of chronic obstructive pulmonary disease 20100101

• Does tiotropium lower exacerbation and hospitalization frequency in COPD patients: results of a meta-analysis.

  BMC pulmonary medicine 20100101

• Indacaterol provides 24-hour bronchodilation in COPD: a placebo-controlled blinded comparison with tiotropium.

  Respiratory research 20100101

• Tiotropium Respimat® improves physical functioning in chronic obstructive pulmonary disease.

  International journal of chronic obstructive pulmonary disease 20100101

• Development and implementation of treadmill exercise testing protocols in COPD.

  International journal of chronic obstructive pulmonary disease 20100101

• Tiotropium increases cytosolic muscarinic M3 receptors and acetylated H3 histone proteins in induced sputum cells of COPD patients.

  European journal of medical research 20100101

• [Triple therapy in chronic obstructive pulmonary disease].

  Archivos de bronconeumologia 20100101

• [The efficacy of tiotropium bromide (spiriva) in the treatment of patients with chronic obstructive pulmonary disease of varying severity: results of the Russian trial].

  Terapevticheskii arkhiv 20100101

• A pilot comparison of helium dilution and plethysmographic lung volumes to assess the impact of a long-acting bronchodilator on lung hyperinflation in COPD.

  Pulmonary pharmacology & therapeutics 20091201

• Alternative mechanisms for tiotropium.

  Pulmonary pharmacology & therapeutics 20091201

• Therapeutic conversion of the combination of ipratropium and albuterol to tiotropium in patients with chronic obstructive pulmonary disease.

  Pulmonary pharmacology & therapeutics 20091201

• Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease.

  American journal of respiratory and critical care medicine 20091115

• On comparing different devices of inhalation products.

  Respiratory medicine 20091101

• Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile.

  The Journal of pharmacology and experimental therapeutics 20091101

• Management of chronic obstructive pulmonary disease: moving beyond the asthma algorithm.

  The Journal of allergy and clinical immunology 20091101

• Inhaled tiotropium bromide and risk of stroke.

  British journal of clinical pharmacology 20091101

• The use of inhaled anticholinergics in chronic obstructive pulmonary disease: is there cause for concern of cardiovascular safety?

  Polskie Archiwum Medycyny Wewnetrznej 20091101

• Nebulized formoterol provides added benefits to tiotropium treatment in chronic obstructive pulmonary disease.

  Advances in therapy 20091101

• Do inhaled anticholinergics increase or decrease the risk of major cardiovascular events?: a synthesis of the available evidence.

  Drugs 20091022

• Efficacy and tolerability of budesonide/formoterol added to tiotropium in patients with chronic obstructive pulmonary disease.

  American journal of respiratory and critical care medicine 20091015

• Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial.

  Lancet (London, England) 20091003

• UPLIFTing care for chronic obstructive pulmonary disease.

  Lancet (London, England) 20091003

• Evaluation of withdrawal of maintenance tiotropium in COPD.

  Respiratory medicine 20091001

• Tiotropium and risk for fatal and nonfatal cardiovascular events in patients with chronic obstructive pulmonary disease: systematic review with meta-analysis.

  Respiratory medicine 20091001

• Combination of formoterol and tiotropium in the treatment of COPD: effects on lung function.

  COPD 20091001

• Anticholinergic treatment in airways diseases.

  Advances in therapy 20091001

• Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials.

  Lancet (London, England) 20090829

• Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).

  Journal of medicinal chemistry 20090827

• Outcomes associated with tiotropium use in patients with chronic obstructive pulmonary disease.

  Archives of internal medicine 20090810

• Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs.

  The Journal of pharmacology and experimental therapeutics 20090801

• Pharmacologic treatments for chronic obstructive pulmonary disease: a mixed-treatment comparison meta-analysis.

  Pharmacotherapy 20090801

• The efficacy and safety of tiotropium in Chinese patients with stable chronic obstructive pulmonary disease: a meta-analysis.

  Respirology (Carlton, Vic.) 20090701

• Preoperative use of inhaled tiotropium in lung cancer patients with untreated COPD.

  Respirology (Carlton, Vic.) 20090701

• Tiotropium-lessons from recent studies.

  Respirology (Carlton, Vic.) 20090701

• Efficacy and safety of nebulized formoterol as add-on therapy in COPD patients receiving maintenance tiotropium bromide: Results from a 6-week, randomized, placebo-controlled, clinical trial.

  Drugs 20090618

• Acute effects of higher than standard doses of salbutamol and ipratropium on tiotropium-induced bronchodilation in patients with stable COPD.

  Pulmonary pharmacology & therapeutics 20090601

• Tiotropium induced bronchodilation and protection from dynamic hyperinflation is independent of extent of emphysema in COPD.

  Pulmonary pharmacology & therapeutics 20090601

• Inhaled muscarinic antagonists for COPD--does an anti-inflammatory mechanism really play a role?

  Current opinion in pharmacology 20090601

• Patient-level pooled analysis of the effect of tiotropium on COPD exacerbations and related hospitalisations.

  Primary care respiratory journal : journal of the General Practice Airways Group 20090601

• Don't prescribe tiotropium for smokers with an FEV1 above 60% predicted.

  Primary care respiratory journal : journal of the General Practice Airways Group 20090601

• Efficacy of tiotropium in the prevention of exacerbations of COPD.

  Therapeutic advances in respiratory disease 20090601

• How safe are anticholinergics in patients with COPD?

  The Medical journal of Australia 20090504

• Tiotropium fumarate: an interesting pharmaceutical co-crystal.

  Journal of pharmaceutical sciences 20090501

• Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response.

  Allergy 20090501

• Long-term bronchodilator inhaled therapy in COPD: the role of tiotropium bromidum.

  Reviews on recent clinical trials 20090501

• Safety and pharmacological profile of tiotropium bromide.

  Expert opinion on drug safety 20090501

• Low frequency oscillometry parameters in COPD patients are less variable during inspiration than during expiration.

  Respiratory physiology & neurobiology 20090430

• Relationship between improved airflow limitation and changes in airway calibre induced by inhaled anticholinergic agents in COPD.

  Thorax 20090401

• Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/fluticasone or tiotropium in COPD.

  The European respiratory journal 20090401

• Effects of arformoterol twice daily, tiotropium once daily, and their combination in patients with COPD.

  Respiratory medicine 20090401

• Biochemical properties, pharmacokinetics and pharmacological response of tiotropium in chronic obstructive pulmonary disease patients.

  Expert opinion on drug metabolism & toxicology 20090401

• Risk of major adverse cardiovascular events with inhaled anticholinergics in patients with chronic obstructive pulmonary disease.

  JAMA 20090325

• Risk of major adverse cardiovascular events with inhaled anticholinergics in patients with chronic obstructive pulmonary disease.

  JAMA 20090325

• Risk of major adverse cardiovascular events with inhaled anticholinergics in patients with chronic obstructive pulmonary disease.

  JAMA 20090325

• Risk of major adverse cardiovascular events with inhaled anticholinergics in patients with chronic obstructive pulmonary disease.

  JAMA 20090325

• Changes in lung function and health status in patients with COPD treated with tiotropium or salmeterol plus fluticasone.

  Respirology (Carlton, Vic.) 20090301

• Interventions to reduce the frequency of exacerbations of chronic obstructive pulmonary disease.

  Postgraduate medical journal 20090301

• After UPLIFT: smoking cessation remains the best intervention in smokers with COPD.

  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20090201

• TORCH and UPLIFT: what has been learned from the COPD 'mega-trials'?

  COPD 20090201

• Formoterol and tiotropium compared with tiotropium alone for treatment of COPD.

  COPD 20090201

• Tiotropium in chronic obstructive pulmonary disease.

  The New England journal of medicine 20090108

• Tiotropium in chronic obstructive pulmonary disease.

  The New England journal of medicine 20090108

• Tiotropium in chronic obstructive pulmonary disease.

  The New England journal of medicine 20090108

• Tiotropium in chronic obstructive pulmonary disease.

  The New England journal of medicine 20090108

• Tiotropium in chronic obstructive pulmonary disease.

  The New England journal of medicine 20090108

• The efficacy of tiotropium administered via Respimat Soft Mist Inhaler or HandiHaler in COPD patients.

  Respiratory medicine 20090101

• The INSPIRE trial results: are they truly breathtaking?

  American journal of respiratory and critical care medicine 20090101

• The effect of tiotropium therapy on markers of elastin degradation in COPD.

  Respiratory research 20090101

• [The UPLIFT study (Understanding Potential Long-term Impacts on Function with Tiotropium)].

  Revue medicale de Liege 20090101

• Validity, reliability, and responsiveness of a new short Visual Simplified Respiratory Questionnaire (VSRQ) for health-related quality of life assessment in chronic obstructive pulmonary disease.

  International journal of chronic obstructive pulmonary disease 20090101

• Study design considerations in a large COPD trial comparing effects of tiotropium with salmeterol on exacerbations.

  International journal of chronic obstructive pulmonary disease 20090101

• [Thiotropium in bronchial asthma].

  Terapevticheskii arkhiv 20090101

• Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT studies.

  International journal of chronic obstructive pulmonary disease 20090101

• The efficacy of tiotropium as a steroid-sparing agent in severe asthma.

  Canadian respiratory journal 20090101

• Impact of frequency of COPD exacerbations on pulmonary function, health status and clinical outcomes.

  International journal of chronic obstructive pulmonary disease 20090101

• Healthcare costs associated with initial maintenance therapy with fluticasone propionate 250 μg/salmeterol 50 μg combination versus anticholinergic bronchodilators in elderly US Medicare-eligible beneficiaries with COPD.

  Journal of medical economics 20090101

• Sequential comparison of tiotropium to high-dose ipratropium in patients with chronic obstructive pulmonary disease in a practice setting.

  International journal of chronic obstructive pulmonary disease 20090101

• Tiotropium HandiHaler in the treatment of COPD: a safety review.

  International journal of chronic obstructive pulmonary disease 20090101

• [Early diagnosis, Uplift and COPD in stage II].

  Pneumologia (Bucharest, Romania) 20090101

• Rational timing of combination therapy with tiotropium and formoterol in moderate and severe COPD.

  Respiratory medicine 20081201

• Uplifting times for COPD.

  Primary care respiratory journal : journal of the General Practice Airways Group 20081201

• Tiotropium does not affect lower urinary tract functions in COPD patients with benign prostatic hyperplasia.

  Pulmonary pharmacology & therapeutics 20081201

• The role of tiotropium in the hospital management of exacerbation of chronic obstructive pulmonary disease.

  Respiratory care 20081201

• Incorporating tiotropium into a respiratory therapist-directed bronchodilator protocol for managing in-patients with COPD exacerbations decreases bronchodilator costs.

  Respiratory care 20081201

• New COPD medications seem okay for the heart.

  Harvard heart letter : from Harvard Medical School 20081201

• Safety, tolerability and risk benefit analysis of tiotropium in COPD.

  International journal of chronic obstructive pulmonary disease 20081201

• Tiotropium and exercise training in COPD patients: effects on dyspnea and exercise tolerance.

  International journal of chronic obstructive pulmonary disease 20081201

• Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro.

  International journal of chronic obstructive pulmonary disease 20081201

• Expected value of perfect information: an empirical example of reducing decision uncertainty by conducting additional research.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20081201

• Cost effectiveness of therapy with combinations of long acting bronchodilators and inhaled steroids for treatment of COPD.

  Thorax 20081101

• Formoterol mono- and combination therapy with tiotropium in patients with COPD: a 6-month study.

  Respiratory medicine 20081101

• [Combination of inhaled salmeterol/fluticasone and tiotropium in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20081101

• A 4-year trial of tiotropium in chronic obstructive pulmonary disease.

  The New England journal of medicine 20081009

• COPD and declining FEV1--time to divide and conquer?

  The New England journal of medicine 20081009

• Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.

  JAMA 20080924

• Bronchodilator efficacy of tiotropium in patients with mild to moderate COPD.

  Primary care respiratory journal : journal of the General Practice Airways Group 20080901

• The INSPIRE study: influence of prior use and discontinuation of inhaled corticosteroids.

  American journal of respiratory and critical care medicine 20080901

• Pharmacokinetics and tolerability (Study 1) with particular reference to ocular safety (Study 2) of tiotropium Respimat soft mist inhaler: findings from two dose-ranging studies in healthy men.

  International journal of chronic obstructive pulmonary disease 20080901

• Comparison of a combination of tiotropium plus formoterol to salmeterol plus fluticasone in moderate COPD.

  Chest 20080801

• Inhaled steroids and COPD.

  The European respiratory journal 20080801

• Survival with tiotropium compared to long-acting Beta-2-agonists in Chronic Obstructive Pulmonary Disease.

  COPD 20080801

• Responses to tiotropium in African-American and Caucasian patients with chronic obstructive pulmonary disease.

  Translational research : the journal of laboratory and clinical medicine 20080801

• Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis.

  Clinical therapeutics 20080801

• Superiority of 'triple' therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD.

  Thorax 20080701

• A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparison.

  Respiratory medicine 20080701

• Treatment step down should be avoided at entry in COPD therapeutic trials.

  American journal of respiratory and critical care medicine 20080701

• Is salmeterol/fluticasone propionate equivalent to tiotropium bromide in the treatment of COPD?

  American journal of respiratory and critical care medicine 20080701

• Management of patients with COPD: a comparison of the INSPIRE and TORCH studies.

  American journal of respiratory and critical care medicine 20080701

• Tiotropium and salmeterol/fluticasone combination do not cause oxygen desaturation in COPD.

  Respiratory medicine 20080601

• Comparison of tiotropium bromide and combined ipratropium/salbutamol for the treatment of COPD: a UK General Practice Research Database 12-month follow-up study.

  Primary care respiratory journal : journal of the General Practice Airways Group 20080601

• Confirmed beta16 Arg/Arg polymorphism in a patient with uncontrolled asthma.

  The Annals of pharmacotherapy 20080601

• Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype.

  The European respiratory journal 20080601

• Isocapnic cold air challenge in patients with COPD: are there any predisposing factors?

  COPD 20080601

• Comparison of the protective effect amongst anticholinergic drugs on methacholine-induced bronchoconstriction in asthma.

  The Journal of asthma : official journal of the Association for the Care of Asthma 20080601

• Effect of tiotropium on health-related quality of life as a primary efficacy endpoint in COPD.

  International journal of chronic obstructive pulmonary disease 20080601

• [Treatment of mild chronic obstructive pulmonary disease].

  Medicina clinica 20080510

• Association of beta2-adrenoreceptor genotypes with bronchodilatory effect of tiotropium in COPD.

  Respirology (Carlton, Vic.) 20080501

• Does tiotropium reduce hospitalizations in chronic obstructive pulmonary disease?

  Annals of internal medicine 20080415

• Frequent mistakes in equivalence studies of generic inhalation products.

  Respiratory medicine 20080401

• Bronchodilator responsiveness in patients with COPD.

  The European respiratory journal 20080401

• Concomitant treatment with nebulized formoterol and tiotropium in subjects with COPD: a placebo-controlled trial.

  Respiratory medicine 20080401

• Sleep-predominant lowering of ambulatory blood pressure by bedtime inhalation of a novel muscarinic M3 receptor antagonist: a new 'bronchoantihypertensive' strategy targeting the lung in hypertension with chronic obstructive pulmonary disease.

  Hypertension research : official journal of the Japanese Society of Hypertension 20080401

• Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism.

  European journal of pharmacology 20080317

• Tiotropium; more knowledge leads to more questions.

  International journal of chronic obstructive pulmonary disease 20080301

• Impairment of small airways in COPD patients with frequent exacerbations and effects of treatment with tiotropium.

  International journal of chronic obstructive pulmonary disease 20080301

• Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients.

  International journal of chronic obstructive pulmonary disease 20080301

• Effect of add-on therapy of tiotropium in COPD treated with theophylline.

  International journal of chronic obstructive pulmonary disease 20080301

• Efficacy of tiotropium inhalation powder in african-american patients with chronic obstructive pulmonary disease.

  COPD 20080201

• Comparable spirometric efficacy of tiotropium compared with salmeterol plus fluticasone in patients with COPD: a pilot study.

  Pulmonary pharmacology & therapeutics 20080101

• Tiotropium improves FEV1 in patients with COPD irrespective of smoking status.

  Pulmonary pharmacology & therapeutics 20080101

• The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide.

  American journal of respiratory and critical care medicine 20080101

• Improvements with tiotropium in COPD patients with concomitant asthma.

  Respiratory medicine 20080101

• A randomized study of tiotropium Respimat Soft Mist inhaler vs. ipratropium pMDI in COPD.

  Respiratory medicine 20080101

• Using cost-effectiveness analysis to sharpen formulary decision-making: the example of tiotropium at the Veterans Affairs health care system.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080101

• Estimating effects from randomized trials with discontinuations: the need for intent-to-treat design and G-estimation.

  Clinical trials (London, England) 20080101

• Tiotropium ameliorates symptoms in patients with chronic airway mucus hypersecretion which is resistant to macrolide therapy.

  Internal medicine (Tokyo, Japan) 20080101

• [Impact of new therapeutic products for the treatment of chronic obstructive pulmonary disease and asthma in primary care in Madrid between 1996 and 2005].

  Gaceta sanitaria 20080101

• [Combination of thiotropium bromide with almitrine and pulmonary rehabilitation in the treatment of patients with chronic obstructive pulmonary disease].

  Terapevticheskii arkhiv 20080101

• [Tiotropium: new about known].

  Terapevticheskii arkhiv 20080101

• Sensitive HPLC-ESI-MS method for the determination of tiotropium in human plasma.

  Journal of chromatographic science 20080101

• Short term effect of a single dose of formoterol or tiotropium on the isolated nocturnal hypoxemia in stable COPD patients: a double blind randomized study.

  European review for medical and pharmacological sciences 20080101

• Tiotropium bromide attenuates respiratory syncytial virus replication in epithelial cells.

  Respiration; international review of thoracic diseases 20080101

• Effect of tiotropium on cough reflex sensitivity in acute viral cough.

  Lung 20080101

• [Effect of tiotropium bromide on exercise tolerance in patients with chronic obstructive pulmonary disease].

  Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20080101

• Socioeconomic gradients in tiotropium use among adults with COPD.

  International journal of chronic obstructive pulmonary disease 20080101

• [The UPLIFT study: future perspectives].

  Archivos de bronconeumologia 20080101

• Tiotropium administered by a pressurized metered dose inhaler (pMDI) and spacer produces a similar bronchodilator response as that administered by a Rotahaler in adult subjects with stable moderate-to-severe COPD.

  Respiratory medicine 20071201

• A dose-ranging study of tiotropium delivered via Respimat Soft Mist Inhaler or HandiHaler in COPD patients.

  International journal of chronic obstructive pulmonary disease 20071201

• Small airways ventilation heterogeneity and hyperinflation in COPD: response to tiotropium bromide.

  International journal of chronic obstructive pulmonary disease 20071201

• [Long-acting bronchodilator agents are the choice in COPD. Keeping the airways open continuously].

  MMW Fortschritte der Medizin 20071122

• Premature discontinuation of patients: a potential bias in COPD clinical trials.

  The European respiratory journal 20071101

• Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro.

  Respiratory medicine 20071101

• Effects of short-acting bronchodilators added to maintenance tiotropium therapy.

  Chest 20071101

• A patient with vanishing lung syndrome and remarkable tolerance to high altitude.

  Medicine and science in sports and exercise 20071101

• Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison.

  The European respiratory journal 20071001

• Lung deposition of radiolabeled tiotropium in healthy subjects and patients with chronic obstructive pulmonary disease.

  Journal of clinical pharmacology 20071001

• The value of early diagnosis for effective management of chronic obstructive pulmonary disease.

  The Journal of family practice 20071001

• [Calculation of morbidity, use of resources and costs of patients treated with tiotropium bromide for COPD in a Spanish population].

  Atencion primaria 20071001

• The combination of tiotropium and budesonide in the treatment of chronic obstructive pulmonary disease.

  Journal of Korean medical science 20071001

• The effect of tiotropium on the pulmonary diffusing capacity.

  Methods and findings in experimental and clinical pharmacology 20071001

• [New COPD guideline. Physical training pays].

  MMW Fortschritte der Medizin 20070906

• Effect of tiotropium bromide on the cardiovascular response to exercise in COPD.

  Respiratory medicine 20070901

• Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD.

  The European respiratory journal 20070901

• Investigating new standards for prophylaxis in reduction of exacerbations--the INSPIRE study methodology.

  COPD 20070901

• Eppur si muove, or COPD treatment success and inflammation.

  The European respiratory journal 20070901

• Tiotropium is less likely to induce oxygen desaturation in stable COPD patients compared to long-acting beta2-agonists.

  Respiratory medicine 20070801

• Cross-reaction allergic pancreatitis with ketoprofen and flurbiprofen.

  Pancreas 20070801

• Enhanced persistence with tiotropium compared with other respiratory drugs in COPD.

  Respiratory medicine 20070701

• A proof of concept study to evaluate stepping down the dose of fluticasone in combination with salmeterol and tiotropium in severe persistent asthma.

  Respiratory medicine 20070601

• Modelling the 5-year cost effectiveness of tiotropium, salmeterol and ipratropium for the treatment of chronic obstructive pulmonary disease in Spain.

  The European journal of health economics : HEPAC : health economics in prevention and care 20070601

• Effects of tiotropium or combined therapy with salmeterol on hyperinflation in COPD.

  Osaka city medical journal 20070601

• Role of tiotropium in the treatment of COPD.

  International journal of chronic obstructive pulmonary disease 20070601

• Outcomes in COPD patients receiving tiotropium or salmeterol plus treatment with inhaled corticosteroids.

  International journal of chronic obstructive pulmonary disease 20070601

• Which bronchodilator in COPD?

  International journal of chronic obstructive pulmonary disease 20070601

• Acetylcholine-induced proliferation of fibroblasts and myofibroblasts in vitro is inhibited by tiotropium bromide.

  Life sciences 20070530

• The additive effect of theophylline on a combination of formoterol and tiotropium in stable COPD: a pilot study.

  Respiratory medicine 20070501

• Oral aphthous-like ulceration due to tiotropium bromide.

  Medicina oral, patologia oral y cirugia bucal 20070501

• Influence of tiotropium on symptoms of chronic obstructive pulmonary disease in a patient with chronic heart failure.

  Circulation journal : official journal of the Japanese Circulation Society 20070501

• Cost-effectiveness of long-acting bronchodilators for chronic obstructive pulmonary disease.

  Mayo Clinic proceedings 20070501

• Summaries for patients. Combination inhaler therapy for chronic obstructive pulmonary disease.

  Annals of internal medicine 20070417

• Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial.

  Annals of internal medicine 20070417

• Effects of replacing oxitropium with tiotropium on pulmonary function in patients with COPD: a randomized study.

  Respiratory medicine 20070301

• Combination inhaled bronchodilator therapy in the management of chronic obstructive pulmonary disease.

  Pharmacotherapy 20070301

• Tiotropium and simplified detection of dynamic hyperinflation.

  Chest 20070301

• The development of anticholinergics in the management of COPD.

  International journal of chronic obstructive pulmonary disease 20070301

• Interfaces to connect the HandiHaler and Aerolizer powder inhalers to a tracheostomy tube.

  Respiratory care 20070201

• [Successful lobectomy in 3 lung cancer cases with severe COPD after treatment with tiotropium bromide].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070201

• Positive interaction of the novel beta2-agonist carmoterol and tiotropium bromide in the control of airway changes induced by different challenges in guinea-pigs.

  Pulmonary pharmacology & therapeutics 20070101

• Tiotropium for the treatment of stable chronic obstructive pulmonary disease: a systematic review with meta-analysis.

  Pulmonary pharmacology & therapeutics 20070101

• A pilot study to assess the effects of combining fluticasone propionate/salmeterol and tiotropium on the airflow obstruction of patients with severe-to-very severe COPD.

  Pulmonary pharmacology & therapeutics 20070101

• Acute angle-closure glaucoma precipitated by local tiotropium absorption.

  Pulmonary pharmacology & therapeutics 20070101

• Improvement of pulmonary function and dyspnea by tiotropium in COPD patients using a transdermal beta(2)-agonist.

  Pulmonary pharmacology & therapeutics 20070101

• Photosensitive lichenoid eruption and inhaled tiotropium bromide.

  Dermatology (Basel, Switzerland) 20070101

• Risk indexes for exacerbations and hospitalizations due to COPD.

  Chest 20070101

• Treatment persistence and compliance with medications for chronic obstructive pulmonary disease.

  Canadian respiratory journal 20070101

• Cardiovascular and respiratory hospitalizations and mortality among users of tiotropium in Denmark.

  European journal of epidemiology 20070101

• Highly sensitive assay for tiotropium, a quaternary ammonium, in human plasma by high-performance liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• Efficacy and safety of tiotropium in COPD patients in primary care--the SPiRiva Usual CarE (SPRUCE) study.

  Respiratory research 20070101

• Use of tiotropium bromide for pre-operative treatment in chronic obstructive pulmonary disease patients: comparison with oxitropium bromide.

  Internal medicine (Tokyo, Japan) 20070101

• [Tiotropium bromide (Spiriva) in stablechronic obstructive pulmonary disease].

  Georgian medical news 20070101

• [Tiotropium--an antiinflammatory drug?].

  Pneumologia (Bucharest, Romania) 20070101

• Comparative safety of long-acting inhaled bronchodilators: a cohort study using the UK THIN primary care database.

  Drug safety 20070101

• A randomized controlled trial to assess the efficacy of tiotropium in Canadian patients with chronic obstructive pulmonary disease.

  Canadian respiratory journal 20070101

• Tiotropium and the treatment of chronic obstructive pulmonary disease.

  Canadian respiratory journal 20070101

• Evaluating the pharmacoeconomic effect of adding tiotropium bromide to the management of chronic obstructive pulmonary disease patients in Singapore.

  Respiratory medicine 20061201

• Tiotropium, a novel muscarinic M3 receptor antagonist, improved symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure.

  Circulation journal : official journal of the Japanese Circulation Society 20061201

• Pooled clinical trial analysis of tiotropium safety.

  Chest 20061201

• Effect of formoterol, tiotropium, and their combination in patients with acute exacerbation of chronic obstructive pulmonary disease: a pilot study.

  Respiratory medicine 20061101

• Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD.

  Journal of applied physiology (Bethesda, Md. : 1985) 20061001

• Tiotropium for stable chronic obstructive pulmonary disease: A meta-analysis.

  Thorax 20061001

• The connection between chronic obstructive pulmonary disease symptoms and hyperinflation and its impact on exercise and function.

  The American journal of medicine 20061001

• The impact of severe exacerbations on quality of life and the clinical course of chronic obstructive pulmonary disease.

  The American journal of medicine 20061001

• Clinical course of chronic obstructive pulmonary disease: review of therapeutic interventions.

  The American journal of medicine 20061001

• The role of patient-centered outcomes in the course of chronic obstructive pulmonary disease: how long-term studies contribute to our understanding.

  The American journal of medicine 20061001

• Does quality of life of COPD patients as measured by the generic EuroQol five-dimension questionnaire differentiate between COPD severity stages?

  Chest 20061001

• Tiotropium in COPD patients not previously receiving maintenance respiratory medications.

  Respiratory medicine 20060901

• Additive benefits of tiotropium in COPD patients treated with long-acting beta agonists and corticosteroids.

  Respirology (Carlton, Vic.) 20060901

• Double-blind randomized parallel group study comparing the efficacy and safety of tiotropium and ipratropium in the treatment of COPD patients in Taiwan.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20060901

• Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor.

  British journal of pharmacology 20060801

• Economic evaluation of tiotropium and salmeterol in the treatment of chronic obstructive pulmonary disease (COPD) in Greece.

  Current medical research and opinion 20060801

• [Can tiotropium bromide favorably influence the course of disease?].

  Medizinische Monatsschrift fur Pharmazeuten 20060801

• Comparison of the acute effect of tiotropium versus a combination therapy with single inhaler budesonide/formoterol on the degree of resting pulmonary hyperinflation.

  Respiratory medicine 20060701

• [Tiotropium, a long-acting bronchodilating agent for the treatment of COPD].

  Nederlands tijdschrift voor geneeskunde 20060603

• Pharmacological assessment of the duration of action of glycopyrrolate vs tiotropium and ipratropium in guinea-pig and human airways.

  British journal of pharmacology 20060601

• [Efficacy of tiotropium bromide (Spiriva) in patients with chronic-obstructive pulmonary disease (COPD) of different severities].

  Pneumologie (Stuttgart, Germany) 20060601

• Cost reduction strategies used by elderly patients with chronic obstructive pulmonary disease to cope with a generic-only pharmacy benefit.

  Journal of managed care pharmacy : JMCP 20060601

• [Comparison of tiotropium inhalation capsules and ipratropium metered dose inhaler in a randomized, double-blind, double-dummy, efficacy and safety study in patients with chronic obstructive pulmonary disease].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20060601

• Tiotropium bromide.

  International journal of chronic obstructive pulmonary disease 20060601

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• Improving dyspnea in chronic obstructive pulmonary disease: optimal treatment strategies.

  Proceedings of the American Thoracic Society 20060501

• What's new in clinical pharmacology and therapeutics.

  WMJ : official publication of the State Medical Society of Wisconsin 20060501

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  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20060501

• COPDX: an update of guidelines for the management of chronic obstructive pulmonary disease with a review of recent evidence.

  The Medical journal of Australia 20060403

• Plethysmography and impulse oscillometry assessment of tiotropium and ipratropium bromide; a randomized, double-blind, placebo-controlled, cross-over study in healthy subjects.

  British journal of clinical pharmacology 20060401

• Comparative costs of tiotropium and ipratropium.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060315

• Anticholinergic agents in asthma and COPD.

  European journal of pharmacology 20060308

• The effect of tiotropium on exacerbations and airflow in patients with COPD.

  The European respiratory journal 20060301

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  Chest 20060301

• Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD.

  Chest 20060301

• Something old, something new, something borrowed. COPD treatment today.

  Advance for nurse practitioners 20060201

• Chronic obstructive pulmonary disease: the evidence for use of tiotropium.

  British journal of hospital medicine (London, England : 2005) 20060201

• Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium.

  Annals of internal medicine 20060117

• Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium.

  Annals of internal medicine 20060117

• Effects of tiotropium and other long acting bronchodilators in chronic obstructive pulmonary disease.

  Pulmonary pharmacology & therapeutics 20060101

• Health outcomes following treatment for 6 months with once daily tiotropium compared with twice daily salmeterol in patients with COPD.

  Thorax 20060101

• The effect of tiotropium on hyperinflation and exercise capacity in chronic obstructive pulmonary disease.

  Respiration; international review of thoracic diseases 20060101

• Onset and duration of action of formoterol and tiotropium in patients with moderate to severe COPD.

  Respiration; international review of thoracic diseases 20060101

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  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060101

• Muscarinic receptor signaling in the pathophysiology of asthma and COPD.

  Respiratory research 20060101

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  Problemy tuberkuleza i boleznei legkikh 20060101

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  Lung 20060101

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  Terapevticheskii arkhiv 20060101

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  Pharmacotherapy 20051201

• Does pulmonary rehabilitation give additional benefit over tiotropium therapy in primary care management of chronic obstructive pulmonary disease? Randomized controlled clinical trial in Hong Kong Chinese.

  Journal of clinical pharmacy and therapeutics 20051201

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  Annals of internal medicine 20050906

• Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trial.

  Annals of internal medicine 20050906

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  Annals of internal medicine 20050906

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  The Annals of pharmacotherapy 20050901

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  Chest 20050901

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  Revue medicale suisse 20050824

• Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD.

  The European respiratory journal 20050801

• Inhalation route inducing subacute cutaneous lupus erythematosus with tiotropium.

  Archives of dermatology 20050701

• Tiotropium: an inhaled anticholinergic for chronic obstructive pulmonary disease.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050615

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  MMW Fortschritte der Medizin 20050512

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  Respiratory medicine 20050501

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  The Cochrane database of systematic reviews 20050418

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• [Postoperative intestinal paralysis caused by the muscarinic receptor blocker tiotropium bromide].

  Der Urologe. Ausg. A 20050401

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  Clinical therapeutics 20050401

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  Current opinion in pulmonary medicine 20050301

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  Chest 20050301

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  Archivos de bronconeumologia 20050301

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  Medicina clinica 20050115

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  Pulmonary pharmacology & therapeutics 20050101

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  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20050101

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  Respiration; international review of thoracic diseases 20050101

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  PharmacoEconomics 20040101

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  Director (Cincinnati, Ohio) 20040101

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  Canadian respiratory journal 20040101

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  COPD 20040101

• Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial.

  COPD 20040101

• Tiotropium bromide: a long-acting anticholinergic bronchodilator for the treatment of patients with chronic obstructive pulmonary disease.

  International journal of clinical practice 20031201

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  Chest 20031101

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  MMW Fortschritte der Medizin 20031030

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  MMW Fortschritte der Medizin 20031016

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  Thorax 20031001

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  Respiratory medicine 20031001

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  Respiratory medicine 20030901

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  The European respiratory journal 20020201

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  The European respiratory journal 20020201

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  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 20020101

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  Life sciences 19930101