140-64-7 | Pentamidine isethionate

Packsize	Purity	Availability	Price	Discounted Price
50mg	95%	in stock	$35.00	$24.00
250mg	95%	in stock	$37.00	$26.00
1g	95%	in stock	$79.00	$55.00
5g	95%	in stock	$246.00	$172.00

Description

• Catalog Number: AD26223
• Chemical Name: Pentamidine isethionate
• CAS Number: 140-64-7
• Molecular Formula: C23H36N4O10S2
• Molecular Weight: 592.6827
• MDL Number: MFCD00079213
• SMILES: NC(=N)c1ccc(cc1)OCCCCCOc1ccc(cc1)C(=N)N.OCCS(=O)(=O)O.OCCS(=O)(=O)O

Computed Properties

• Complexity: 493
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 39
• Hydrogen Bond Acceptor Count: 12
• Hydrogen Bond Donor Count: 8
• Rotatable Bond Count: 14

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• [Management of American cutaneous leishmaniasis. Outcome apropos of 326 cases treated with high-dose pentamidine isethionate].

  Medecine tropicale : revue du Corps de sante colonial 20030101

• [A comparative study between the efficacy of pentamidine isothionate given in three doses for one week and N-methil-glucamine in a dose of 20mgSbV/day for 20 days to treat cutaneous leishmaniasis].

  Revista da Sociedade Brasileira de Medicina Tropical 20030101

• [The return of sleeping sickness in an epidemic form: international action for drugs].

  Nederlands tijdschrift voor geneeskunde 20021228

• Pentamidine is an inhibitor of PRL phosphatases with anticancer activity.

  Molecular cancer therapeutics 20021201

• Development of novel assays for proteolytic enzymes using rhodamine-based fluorogenic substrates.

  Journal of biomolecular screening 20021201

• Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove.

  Journal of the American Chemical Society 20021120

• Pentamidine, the drug of choice for the treatment of cutaneous leishmaniasis in Surinam.

  International journal of dermatology 20021101

• T wave alternans and Torsades de Pointes after the use of intravenous pentamidine.

  Journal of cardiovascular electrophysiology 20020901

• Promising therapeutic targets for antileishmanial drugs.

  Expert opinion on therapeutic targets 20020801

• [Pneumocystis carinii pneumonia in patients with connective tissue diseases].

  Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20020801

• In vitro activities of pentamidine, pyrimethamine, trimethoprim, and sulfonamides against Aspergillus species.

  Antimicrobial agents and chemotherapy 20020601

• Prophylaxis for human immunodeficiency virus-related Pneumocystis carinii pneumonia: using simulation modeling to inform clinical guidelines.

  Archives of internal medicine 20020422

• Leishmaniases and HIV/AIDS co-infections: review of common features and management experiences.

  Ethiopian medical journal 20020401

• Intravenous pentamidine induced megaloblastic anaemia.

  Haematologica 20020101

• [Rhabdomyolysis induced by pentamidine (Pentacarinat) during treatment of cutaneous leishmaniasis: 2 cases].

  Annales de dermatologie et de venereologie 20020101

• Pneumocystis carinii pneumonia in patients with Diamond-Blackfan anemia receiving high-dose corticosteroids.

  Journal of pediatric hematology/oncology 20020101

• A novel HPLC assay for pentamidine: comparative effects of creatinine and inulin on GFR estimation and pentamidine renal excretion in the isolated perfused rat kidney.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20020101

• Uptake of pentamidine in Trypanosoma brucei brucei is mediated by the P2 adenosine transporter and at least one novel, unrelated transporter.

  Acta tropica 20011221

• High intralesional interleukin-10 messenger RNA expression in localized cutaneous leishmaniasis is associated with unresponsiveness to treatment.

  The Journal of infectious diseases 20011215

• Seasonal fluctuations of incubation, healing delays, and clinical presentation of cutaneous leishmaniasis in French Guiana.

  The Journal of parasitology 20011201

• Pentamidine isethionate as treatment and secondary prophylaxis for disseminated cutaneous leishmaniasis during HIV infection: case report.

  Journal of chemotherapy (Florence, Italy) 20011201

• New insights into transmission, diagnosis, and drug treatment of Pneumocystis carinii pneumonia.

  JAMA 20011121

• Drug resistance in Indian visceral leishmaniasis.

  Tropical medicine & international health : TM & IH 20011101

• Availability and affordability of treatment for Human African Trypanosomiasis.

  Tropical medicine & international health : TM & IH 20011101

• Treatment of visceral leishmaniasis.

  Medical microbiology and immunology 20011101

• Flow cytometry, a useful tool for detecting the lethal effect of pentamidine on Leishmania viannia complex promastigote forms.

  Pharmacological research 20011001

• [Guidelines for Prevention of Pneumocystis carinii Pneumonitis in Children and Adolescents with Cancer].

  Klinische Padiatrie 20010901

• A meta-analysis of salvage therapy for Pneumocystis carinii pneumonia.

  Archives of internal medicine 20010625

• Influence of clinical presentation on the efficacy of a short course of pentamidine in the treatment of cutaneous leishmaniasis in French Guiana.

  Annals of tropical medicine and parasitology 20010601

• Trypanocidal activity of dicationic compounds related to pentamidine.

  European journal of medicinal chemistry 20010601

• A randomized clinical trial of low dosage combination of pentamidine and allopurinol in the treatment of antimony unresponsive cases of visceral leishmaniasis.

  The Journal of the Association of Physicians of India 20010601

• Prevention of invasive aspergillosis in AIDS by sulfamethoxazole.

  AIDS (London, England) 20010525

• Diamidine compounds: selective uptake and targeting in Plasmodium falciparum.

  Molecular pharmacology 20010501

• Transporters in African trypanosomes: role in drug action and resistance.

  International journal for parasitology 20010501

• Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals.

  Molecular pharmacology 20010301

• Antitrypanosomal properties of cis-platinum-pentamidine bromide, thiocyanate and seleniocyanate on Trypanosoma brucei brucei mouse and sheep models.

  Journal of chemotherapy (Florence, Italy) 20010201

• [Human African trypanosomiasis from Trypanosoma brucei gambiense with inoculation chancre in a French expatriate].

  Medecine tropicale : revue du Corps de sante colonial 20010101

• In vitro effect of diamidines on intracellular polyamines of Acanthamoeba polyphaga.

  Drugs under experimental and clinical research 20010101

• Standardization of an in vitro drug screening assay by use of cryopreserved and characterized Pneumocystis carinii populations.

  The Journal of eukaryotic microbiology 20010101

• Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii.

  Antimicrobial agents and chemotherapy 20000301

• Serum neopterin concentrations during treatment of leishmaniasis: useful as test of cure?

  FEMS immunology and medical microbiology 20000101

• Atovaquone suspension compared with aerosolized pentamidine for prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected subjects intolerant of trimethoprim or sulfonamides.

  The Journal of infectious diseases 19990801

• Pentamidine is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 receptors.

  Annals of the New York Academy of Sciences 19990621

• Pentamidine-induced hemolytic anemia in an AIDS patient.

  The Annals of pharmacotherapy 19990401

• In vitro antimicrobial activity of aromatic diamidines and diimidazolines related to pentamidine.

  European journal of medicinal chemistry 19990101

• Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.

  Antimicrobial agents and chemotherapy 19981001

• 1,5-Bis(4-amidinophenoxy)pentane (pentamidine) is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 binding sites.

  European journal of pharmacology 19980717

• Torsades de pointes complicating pentamidine therapy of Pneumocystis carinii pneumonia in acute myelogenous leukemia.

  Internal medicine (Tokyo, Japan) 19971001

• A prospective study of the effect of I.V. pentamidine therapy on ventricular arrhythmias and QTc prolongation in HIV-infected patients.

  Chest 19970901

• A man with AIDS experiences near-syncope.

  Chest 19970201

• [Sinus bradycardia secondary to systemic pentamidine].

  Revista espanola de cardiologia 19961201

• Treatment of New World cutaneous and mucosal leishmaniases.

  Clinics in dermatology 19960101

• Acute severe autonomic insufficiency during pentamidine therapy.

  Southern medical journal 19951001

• Problems in the treatment of kala-azar: case report.

  East African medical journal 19950601

• [Macroscopic hematuria secondary to the administration of intravenous pentamidine].

  Enfermedades infecciosas y microbiologia clinica 19950501

• Successful treatment of Pneumocystis carinii Pneumonia in mice with benanomicin A (ME1451).

  Antimicrobial agents and chemotherapy 19950301

• Changes in taste associated with intravenous administration of pentamidine.

  The Journal of the Association of Nurses in AIDS Care : JANAC 19950101

• Pentamidine congeners. 2. 2-butene-bridged aromatic diamidines and diimidazolines as potential anti-Pneumocystis carinii pneumonia agents.

  Journal of medicinal chemistry 19941223

• Activity of terbinafine against Pneumocystis carinii in vitro and its efficacy in the treatment of experimental pneumonia.

  The Journal of antimicrobial chemotherapy 19941101

• Torsade de pointes and elevated magnesium and calcium requirements associated with intravenous pentamidine.

  Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 19941001

• Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model.

  The Journal of infectious diseases 19941001

• [An atrioventricular block secondary to pentamidine treatment].

  Medicina clinica 19940924

• Effect of pentamidine on the growth of Cryptococcus neoformans.

  The Journal of antimicrobial chemotherapy 19940601

• DNA-binding activity and biological effects of aromatic polyamidines.

  Biochemical pharmacology 19940211

• Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients.

  Chest 19940201

• Cardiac arrest after intravenous pentamidine in an infant.

  The Pediatric infectious disease journal 19930801

• The accumulation of pentamidine and the toxic effects of the drug, its selected analogues and metabolites on isolated alveolar cells.

  Toxicology 19930604

• Case report: pentamidine and polymorphic ventricular tachycardia revisited.

  The American journal of the medical sciences 19930401

• [Myocardial stunning during treatment with pentamidine isethionate].

  Annales de medecine interne 19930101

• Torsade de pointes after inhaled pentamidine.

  Annals of emergency medicine 19921101

• Prolonged recurrence of pentamidine-induced torsades de pointes.

  The Annals of pharmacotherapy 19921101

• Higher pentamidine levels in AIDS patients with hypoglycemia and azotemia during treatment of Pneumocystis carinii pneumonia.

  The American review of respiratory disease 19920901

• High pentamidine levels associated with hypoglycemia and azotemia in a patient with Pneumocystis carinii pneumonia.

  Diagnostic microbiology and infectious disease 19920801

• Hematuria associated with pentamidine therapy for Pneumocystis carinii pneumonia.

  AIDS (London, England) 19920601

• Cardiac arrest during treatment of Pneumocystis carinii pneumonia with intravenous pentamidine isethionate.

  Scandinavian journal of infectious diseases 19920101

• Pentamidine-associated nephrotoxicity and hyperkalemia in patients with AIDS.

  DICP : the annals of pharmacotherapy 19911101

• [Infantile visceral leishmaniasis in Morocco. A review of 67 cases managed at the Rabat Hospital for children (1979-1988)].

  Annales de pediatrie 19910901

• Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.

  Antimicrobial agents and chemotherapy 19910701

• [Transitory acute kidney insufficiency and insulin-dependent after treatment of kala-azar with pentamidine and N-methylglucamine antimony].

  Archives francaises de pediatrie 19910501

• Pentamidine-induced facial numbness.

  Clinical pharmacy 19910401

• Inhibition of topoisomerases from Pneumocystis carinii by aromatic dicationic molecules.

  The Journal of protozoology 19910101

• Treatment of experimental Pneumocystis carinii pneumonia with 1,3-di(4-imidazolino-2-methoxyphenoxy)propane lactate.

  The Journal of protozoology 19910101

• Effects of pentamidine alone and in combination with ketoconazole or itraconazole on the growth of Candida albicans.

  Antimicrobial agents and chemotherapy 19901201

• Ventricular tachycardia and torsades de pointes complicating pentamidine therapy of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.

  The American journal of cardiology 19901001

• Symptomatic hypocalcemia and hypomagnesemia with renal magnesium wasting associated with pentamidine therapy in a patient with AIDS.

  The American journal of medicine 19900901

• Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis.

  Antimicrobial agents and chemotherapy 19900701

• Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia.

  Antimicrobial agents and chemotherapy 19900601

• Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.

  Journal of medicinal chemistry 19900401

• Pentamidine-induced torsades de pointes in a renal transplant recipient with Pneumocystis carinii pneumonia.

  Southern medical journal 19900401

• Acute, rapidly progressive renal failure with simultaneous use of amphotericin B and pentamidine.

  Antimicrobial agents and chemotherapy 19900301

• Renal insufficiency with nebulised pentamidine.

  Lancet (London, England) 19891028

• Nephrotoxicity and hyperkalemia in patients with acquired immunodeficiency syndrome treated with pentamidine.

  The American journal of medicine 19890901

• Acute renal failure after nebulised pentamidine.

  Lancet (London, England) 19890603

• Torsades de pointes during intravenous pentamidine isethionate therapy.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 19890115

• Recurrent ventricular tachycardia due to pentamidine-induced cardiotoxicity.

  Chest 19881201

• Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study.

  Annals of internal medicine 19880815

• Risk factors for hypoglycemia associated with pentamidine therapy for Pneumocystis pneumonia.

  JAMA 19880715

• Comparison of dosages, intervals, and drugs in the prevention of Pneumocystis carinii pneumonia.

  Antimicrobial agents and chemotherapy 19880501

• Ventricular tachycardia due to pentamidine isethionate.

  The American journal of medicine 19880501

• Torsade de pointes during administration of pentamidine isethionate.

  The American journal of medicine 19870901

• Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.

  The Journal of infectious diseases 19870501

• Adverse reactions associated with pentamidine isethionate in AIDS patients: recommendations for monitoring therapy.

  Drug intelligence & clinical pharmacy 19861101

• Pentamidine and hematuria.

  Annals of internal medicine 19860701

• Hypoglycemic coma from pentamadine in an AIDS patient.

  The American journal of emergency medicine 19860701

• Pentamidine-induced hypoglycemia in patients with the acquired immune deficiency syndrome.

  Clinical pharmacology and therapeutics 19860301

• Pentamidine treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Association with acute renal failure and myoglobinuria.

  Archives of internal medicine 19851201

• Sciatic nerve damage associated with pentamidine.

  Drug intelligence & clinical pharmacy 19851001

• Pentamidine and renal toxicity.

  The New England journal of medicine 19850912

• Pentamidine-associated hypotension and route of administration.

  Annals of internal medicine 19850901

• Visceral leishmaniasis unresponsive to antimonial drugs. II. Response to high dosage sodium stibogluconate or prolonged treatment with pentamidine.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 19850101

• Evaluation of diamidine compound (pentamidine isethionate) in the treatment resistant cases of kala-azar occurring in North Bihar, India.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 19830101

• Response of babesiosis to pentamidine therapy.

  Annals of internal medicine 19810301

• [Nephrotoxic effect of pentamidine in the treatment of interstitial pneumonia in 2 children with acute lymphoblastic leukemia].

  Ceskoslovenska pediatrie 19791201

• [Kidney failure during treatment of T. rhodesiense trypanosomiasis with pentamidin].

  Annales de la Societe belge de medecine tropicale 19770101

• [Severe renal and pancreatic complications during treatment with pentamidine in African trypanosomiasis].

  Annales de medecine interne 19750101