14003-96-4 | 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$25.00	$17.00
5mg	98%	in stock	$56.00	$39.00
10mg	98%	in stock	$82.00	$57.00
25mg	98%	in stock	$123.00	$86.00
50mg	98%	in stock	$186.00	$130.00
250mg	98%	in stock	$473.00	$331.00
1g	98%	in stock	$1,279.00	$895.00

Description

• Catalog Number: AA61959
• Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde
• CAS Number: 14003-96-4
• Molecular Formula: C11H8O4
• Molecular Weight: 204.1788
• MDL Number: MFCD12027255
• SMILES: O=Cc1c(O)ccc2c1oc(=O)cc2C

Computed Properties

• Complexity: 321
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 1.5

Upstream Synthesis Route

2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-4-methyl-2-oxo-, commonly known as $name$, is a versatile compound widely used in chemical synthesis. This compound serves as a key building block in the creation of various pharmaceuticals, agrochemicals, and fine chemicals due to its unique structural properties. Its ability to act as a precursor in the synthesis of complex heterocyclic compounds makes it a valuable tool for medicinal chemists and organic chemists alike. In particular, $name$ is frequently employed in the development of novel drug candidates, where its reactive nature and functional groups facilitate the construction of diverse molecular architectures with potentially beneficial properties. Furthermore, its presence in the synthesis of natural products highlights its significance in accessing biologically active compounds with therapeutic potential. By participating in a range of chemical transformations, including condensation reactions, cyclization processes, and functional group modifications, $name$ plays a crucial role in expanding the chemical space and enabling the discovery of new molecules with targeted properties.

Literature

• Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.

  Journal of medicinal chemistry 20140522

• Synthesis, spectroscopic characterization and biological evaluation studies of Schiff's base derived from naphthofuran-2-carbohydrazide with 8-formyl-7-hydroxy-4-methyl coumarin and its metal complexes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121201

• 8-Formyl-4-methyl-2-oxo-2H-chromen-7-yl 4-methyl-benzenesulfonate.

  Acta crystallographica. Section E, Structure reports online 20110601

• Synthesis, physico-chemical investigations of Co(II), Ni(II) and Cu(II) complexes and their in vitro microbial, cytotoxic, DNA cleavage studies.

  Journal of enzyme inhibition and medicinal chemistry 20100601

• DNA cleavage and in vitro antimicrobial studies of Co(II), Ni(II), and Cu(II) complexes with ONNO donor Schiff bases: synthesis, spectral characterization, and electrochemical studies.

  Journal of enzyme inhibition and medicinal chemistry 20100201

• Synthesis, characterization, DNA cleavage and in vitro antimicrobial studies of La(III), Th(IV) and VO(IV) complexes with Schiff bases of coumarin derivatives.

  European journal of medicinal chemistry 20090701

• Synthesis, spectral characterization, in vitro microbial and cytotoxic studies of lanthanum(III) and thorium(IV) complexes with 1,2,4-triazole Schiff bases.

  Journal of enzyme inhibition and medicinal chemistry 20090601

• Synthesis, spectral characterization and in vitro biological studies of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases.

  Journal of enzyme inhibition and medicinal chemistry 20090401

• Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases.

  European journal of medicinal chemistry 20081201

• Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships.

  Journal of medicinal chemistry 20080227