14080-50-3 | Thieno[2,3-d]pyrimidin-4-ol

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$9.00	$6.00
5g	98%	in stock	$20.00	$14.00
10g	95%	in stock	$23.00	$17.00
25g	95%	in stock	$55.00	$39.00

Description

• Catalog Number: AA63044
• Chemical Name: Thieno[2,3-d]pyrimidin-4-ol
• CAS Number: 14080-50-3
• Molecular Formula: C6H4N2OS
• Molecular Weight: 152.1738
• MDL Number: MFCD00706456
• SMILES: O=c1nc[nH]c2c1ccs2

Computed Properties

• Complexity: 192
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• XLogP3: 0.7

Upstream Synthesis Route

Thieno[2,3-d]pyrimidin-4(1H)-one, also known as $name$, serves as a valuable building block in chemical synthesis due to its versatile reactivity and functionality. This compound is commonly utilized in the pharmaceutical industry for the development of novel drugs and bioactive molecules. Its unique structure allows for the introduction of various functional groups, making it a key intermediate in the synthesis of diverse compounds.In organic synthesis, $name$ is frequently employed as a heterocyclic scaffold for the construction of complex molecules. Its presence in the chemical structure imparts desirable properties to the final products, such as enhanced biological activity or improved stability. By incorporating $name$ into the synthesis pathway, chemists can access a wide range of potential drug candidates and bioactive compounds.Furthermore, the reactivity of $name$ enables chemists to perform various types of chemical transformations, including functional group modifications, ring-closure reactions, and cross-coupling reactions. This versatility makes it a valuable tool for designing and synthesizing molecules with specific properties or functions.Overall, the application of Thieno[2,3-d]pyrimidin-4(1H)-one in chemical synthesis offers a pathway to the creation of diverse and innovative molecules with potential applications in drug discovery, medicinal chemistry, and materials science.

Literature

• Thieno[2,3-d]pyrimidinedione derivatives as antibacterial agents.

  European journal of medicinal chemistry 20120501

• Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1).

  PloS one 20120101

• Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation.

  PloS one 20110101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• 9-Furfuryl-idene-2,3-dimethyl-6,7,8,9-tetrahydro-4H--thieno[2',3':4,5]pyrimidino[1,2-a]pyridin-4-one.

  Acta crystallographica. Section E, Structure reports online 20100301

• Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core.

  Journal of medicinal chemistry 20091112

• Diversification of a thieno[2,3-d]pyrimidin-4-one scaffold via regioselective alkylation reactions.

  Journal of combinatorial chemistry 20090101

• The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network.

  The Biochemical journal 20080915

• A 3D QSAR model of 17beta-HSD1 inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core applying molecular dynamics simulations and ligand-protein docking.

  ChemMedChem 20080301