14173-39-8 | 4-Chloro-l-phenylalanine

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$13.00	$9.00
5g	97%	in stock	$16.00	$12.00
10g	97%	in stock	$27.00	$19.00
25g	97%	in stock	$67.00	$47.00
500g	97%	in stock	$1,193.00	$835.00

Description

• Catalog Number: AA68418
• Chemical Name: 4-Chloro-l-phenylalanine
• CAS Number: 14173-39-8
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.6342
• MDL Number: MFCD00063065
• SMILES: N[C@H](C(=O)O)Cc1ccc(cc1)Cl

Computed Properties

• Complexity: 179
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: -0.5

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• Up-regulation of P-glycoprotein expression in small intestine under chronic serotonin-depleted conditions in rats.

  The Journal of pharmacology and experimental therapeutics 20050101

• Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position.

  Biochemical pharmacology 20050101

• [Astroglia formation in the neocortex of mice after temporary prenatal serotonin depletion].

  Morfologiia (Saint Petersburg, Russia) 20050101

• The role of 5-HT1A receptors in the proliferation and survival of progenitor cells in the dentate gyrus of the adult hippocampus and their regulation by corticoids.

  Neuroscience 20050101

• Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system.

  European journal of pharmacology 20041215

• Elevated serotonin is involved in hyperactivity but not in the paradoxical effect of amphetamine in mice neonatally lesioned with 6-hydroxydopamine.

  Journal of neuroscience research 20041015

• 5-HT-mediated inhibition of cardiovagal baroreceptor reflex response during defense reaction in the rat.

  American journal of physiology. Heart and circulatory physiology 20041001

• Effects of autacoid inhibitors and of an antagonist on malaria infection in mice.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040801

• Immediate plasticity in the motor pathways after spinal cord hemisection: implications for transcranial magnetic motor-evoked potentials.

  Experimental neurology 20040601

• NMDA receptor subunit and CaMKII changes in rat hippocampus induced by acute MDMA treatment: a mechanism for learning impairment.

  Psychopharmacology 20040501

• ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models.

  Synapse (New York, N.Y.) 20040501

• Stimulation of the immune response during activation of the dopaminergic system in mice with opposite types of behavior.

  Neuroscience and behavioral physiology 20040501

• 5-HT has contrasting effects in the frontal cortex, but not the hypothalamus, on changes in noradrenaline efflux induced by the monoamine releasing-agent, d-amphetamine, and the reuptake inhibitor, BTS 54 354.

  Neuropharmacology 20040301

• Brain serotonin depletion enhances the sodium appetite induced by sodium depletion or beta-adrenergic stimulation.

  Anais da Academia Brasileira de Ciencias 20040301

• The central serotonergic system mediates the analgesic effect of electroacupuncture on ZUSANLI (ST36) acupoints.

  Journal of biomedical science 20040101

• Serotonergic and dopaminergic influence of the duration of embryogenesis and intracapsular locomotion of Lymnaea stagnalis L.

  Acta biologica Hungarica 20040101

• 5-HT1A and beta-adrenergic receptors regulate proliferation of rat blood lymphocytes.

  Neuroimmunomodulation 20040101

• Depletion and restoration of endogenous monoamines affects beta-CIT binding to serotonin but not dopamine transporters in non-human primates.

  Journal of neural transmission. Supplementum 20040101

• Emetic action of the prostanoid TP receptor agonist, U46619, in Suncus murinus (house musk shrew).

  European journal of pharmacology 20031215

• Effects of fenfluramine and antidepressants on protein kinase C activity in rat cortical synaptoneurosomes.

  Synapse (New York, N.Y.) 20031201

• Expression of tryptophan 5-hydroxylase gene during sea urchin neurogenesis and role of serotonergic nervous system in larval behavior.

  The Journal of comparative neurology 20031110

• Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice.

  Behavioural brain research 20031017

• Elimination of serotonergic cells induces a marked increase in generation of dopaminergic neurons from mesencephalic precursors.

  The European journal of neuroscience 20031001

• Role of serotonergic mechanisms in leptin-induced suppression of milk intake in mice.

  Neuroscience letters 20030918

• The effects of serotonin on the differentiation of neurons producing vasoactive intestinal polypeptide in the suprachiasmatic nucleus of the rat.

  Neuroscience and behavioral physiology 20030901

• Effect of the inhibition of serotonin biosynthesis on the antinociception induced by nonsteroidal anti-inflammatory drugs.

  Brain research bulletin 20030830

• Characterization of tryptophan high affinity transport system in pinealocytes of the rat. Day-night modulation.

  Amino acids 20030701

• m-CPP-induced self-grooming is mediated by 5-HT2C receptors.

  Behavioural brain research 20030616

• Influence of serotonin on the development and migration of gonadotropin-releasing hormone neurones in rat foetuses.

  Journal of neuroendocrinology 20030601

• Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration.

  Journal of neurochemistry 20030601

• Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors.

  Neuropharmacology 20030401

• Increases in avoidance responding produced by REM sleep deprivation or serotonin depletion are reversed by administration of 5-hydroxytryptophan.

  Behavioural brain research 20030318

• Serotonin-GABA interactions in the modulation of mu- and kappa-opioid analgesia.

  Neuropharmacology 20030301

• Serotonin depletion increases respiratory variability in freely moving rats: implications for panic disorder.

  The international journal of neuropsychopharmacology 20030301

• Host brain regulation of dopaminergic grafts function: role of the serotonergic and noradrenergic systems in amphetamine-induced responses.

  Synapse (New York, N.Y.) 20030101

• Lack of effects by tricyclic antidepressant and serotonin inhibitors on anorexia in MCG 101 tumor-bearing mice with eicosanoid-related cachexia.

  Nutrition (Burbank, Los Angeles County, Calif.) 20030101

• [Neurochemical analysis and pharmacological regulation of the corticofugal control of the nociceptive signals in the afferent pathways].

  Eksperimental'naia i klinicheskaia farmakologiia 20030101

• Decreased serotonin level during pregnancy alters morphological and functional characteristics of tonic nociceptive system in juvenile offspring of the rat.

  Reproductive biology and endocrinology : RB&E 20030101

• Neural stem cells and the regulation of adult neurogenesis.

  Reproductive biology and endocrinology : RB&E 20030101

• Depletion of endogenous serotonin synthesis with p-CPA attenuates upregulation of constitutive isoform of heme oxygenase-2 expression, edema formation and cell injury following a focal trauma to the rat spinal cord.

  Acta neurochirurgica. Supplement 20030101

• Pharmacological blockage of serotonin biosynthesis and circadian changes in oxaliplatin toxicity in rats.

  Chronobiology international 20021101

• [Activation of dopaminergic system stimulates an immune response in mice with opposite type of behaviour].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20021101

• MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities.

  European journal of pharmacology 20021025

• FR143166 attenuates spinal pain transmission through activation of the serotonergic system.

  European journal of pharmacology 20021011

• Neither increased nor decreased availability of cortical serotonin (5HT) disturbs barrel field formation in isocaloric undernourished rat pups.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20021001

• The spinal antinociceptive effect of kyotorphin in mice: involvement of the descending noradrenergic and serotonergic systems.

  Neuroscience letters 20020830

• Postsynaptic 5-HT(1A) receptors mediate an increase in locomotor activity in the monoamine-depleted rat.

  Psychopharmacology 20020801

• Modulation of serotonergic projection from dorsal raphe nucleus to basolateral amygdala on sleep-waking cycle of rats.

  Brain research 20020726

• Decreased marble burying behavior in female mice lacking neuromedin-B receptor (NMB-R) implies the involvement of NMB/NMB-R in 5-HT neuron function.

  Brain research 20020628

• Postural modifications and neuronal excitability changes induced by a short-term serotonin depletion during neonatal development in the rat.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020615

• The inhibition of tryptophan hydroxylase, not protein synthesis, reduces the brain trapping of alpha-methyl-L-tryptophan: an autoradiographic study.

  Neurochemistry international 20020601

• Effect of NMDA antagonists, an NMDA agonist, and serotonin depletion on acute tolerance to ethanol.

  Pharmacology, biochemistry, and behavior 20020501

• Modulation of 5-HT4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine.

  British journal of pharmacology 20020501

• Effect of rofecoxib on nociception and the serotonin system in the rat brain.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020301

• Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus.

  Life sciences 20020208

• Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster.

  The Journal of pharmacology and experimental therapeutics 20020101

• Counteraction of the rapid tolerance to 8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia in rats by activation of the GABAA receptor-chloride channel complex.

  Pharmacology & toxicology 20020101

• Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat.

  Muscle & nerve. Supplement 20020101

• [Behavioral effects of L-tryptophan and p-chlorophenylalanine after adrenalectomy or dexamethasone administration in rats].

  Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20020101

• Self-biting induced by activation of L-type calcium channels in mice: serotonergic influences.

  Developmental neuroscience 20020101

• Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: Involvement of serotonin-1A, GABA(A), and glutamate receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20011215

• Plasma glucose-lowering effect of tramadol in streptozotocin-induced diabetic rats.

  Diabetes 20011201

• Reversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides.

  FEBS letters 20011102

• Effects of endogenous neurotransmitters on the in vivo binding of dopamine and 5-HT radiotracers in mice.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011101

• Estradiol and para-chlorophenylalanine downregulate the expression of brain aromatase and estrogen receptor-alpha mRNA during the critical period of feminization in tilapia (Oreochromis mossambicus).

  Neuroendocrinology 20011101

• Serotonin mediates oestrogen stimulation of cell proliferation in the adult dentate gyrus.

  The European journal of neuroscience 20011101

• p-Chlorophenylalanine eliminates long-term modulation of the exercise ventilatory response in goats.

  Respiration physiology 20011101

• Altered responsiveness to 5-HT at the crayfish neuromuscular junction due to chronic p-CPA and m-CPP treatment.

  Brain research 20011019

• Effects of serotonin synthesis blockade on interleukin-1 beta action in the brain of rats.

  Brain research 20011012

• Serotonin depletion attenuates cocaine seeking but enhances sucrose seeking and the effects of cocaine priming on reinstatement of cocaine seeking in rats.

  Psychopharmacology 20011001

• [Tyrosine hydroxylase expression in differentiating neurons of the rat arcuate nucleus: inhibitory effect of serotoninergic afferents].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20011001

• The spinal antinociceptive effect of FR140423 in mice involvement of the descending noradrenergic and serotonergic systems.

  Life sciences 20010928

• Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice.

  The Journal of pharmacology and experimental therapeutics 20010901

• In vivo resetting of the hamster circadian clock by 5-HT7 receptors in the suprachiasmatic nucleus.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010715

• Effect of serotonin depletion by p-chlorophenylalanine on serum prolactin levels in estrogen-treated ovariectomized rats: insights concerning the serotoninergic, dopaminergic and opioid systems.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20010601

• Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice.

  European journal of nutrition 20010601

• Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin.

  European journal of pharmacology 20010420

• Reduced brain serotonin activity disrupts prepulse inhibition of the acoustic startle reflex. Effects of 5,7-dihydroxytryptamine and p-chlorophenylalanine.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010401

• Pharmacological studies on the monoaminergic influence on the synthesis and expression of neuropeptide Y and corticotropin releasing factor in rat brain amygdala.

  Neuropeptides 20010401

• Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats.

  Pharmacology, biochemistry, and behavior 20010401

• Disruption of neuroendocrine control of luteinizing hormone secretion by aroclor 1254 involves inhibition of hypothalamic tryptophan hydroxylase activity.

  Biology of reproduction 20010301

• Apomorphine-induced aggressive behaviour in para-chlorophenylalanine-treated male rats: implications to brain.

  Pharmacology & toxicology 20010301

• Effects of p-chlorophenylalanine on striatal acetylcholinesterase activity and on biogenic amine levels in nuclei raphe and caudate-putamen during physostigmine-induced tremor in rats.

  Neuroscience letters 20010216

• Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat.

  The Journal of physiology 20010201

• Behavioral effects of para-chlorophenylalanine in gonadectomized male rats.

  Bulletin of experimental biology and medicine 20010201

• Postnatal secretion of the subcommissural organ of the Meriones shawi: control of serotonin innervation.

  Brain research. Developmental brain research 20010131

• Nitric oxide modulates lithium-induced conditioned taste aversion.

  Behavioural brain research 20010129

• Occurrence of a unique protein toxin from the Indian King Cobra (Ophiophagus hannah) venom.

  Toxicon : official journal of the International Society on Toxinology 20010101

• Acute antidepressant-like and antianxiety-like effects of tryptophan in mice.

  Pharmacology 20010101

• Evaluation of genotoxity and mutagenicity of DL-p-chlorophenylalanine, its methyl ester and some N-acyl derivatives.

  Acta biologica Hungarica 20010101