142-08-5 | Pyridin-2-ol

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$8.00	$5.00
10g	98%	in stock	$12.00	$8.00
25g	98%	in stock	$15.00	$10.00
100g	98%	in stock	$48.00	$33.00

Description

• Catalog Number: AI34787
• Chemical Name: Pyridin-2-ol
• CAS Number: 142-08-5
• Molecular Formula: C5H5NO
• Molecular Weight: 95.0993
• MDL Number: MFCD00006268
• SMILES: O=c1cccc[nH]1

Computed Properties

• Complexity: 135
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 7
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• XLogP3: -0.6

Upstream Synthesis Route

2-Hydroxypyridine, also known as 2-pyridone, is a versatile chemical compound widely utilized in various chemical synthesis processes. This compound serves as a vital building block in the pharmaceutical industry, particularly in the synthesis of pharmaceutical drugs and bioactive molecules. Due to its unique structural properties, 2-Hydroxypyridine plays a crucial role in the development of novel drug candidates and therapeutic agents.In chemical synthesis, 2-Hydroxypyridine is commonly employed as a precursor in the production of heterocyclic compounds. The reactive hydroxyl group on the pyridine ring enables diverse functionalization reactions, allowing for the introduction of different chemical moieties to generate new compounds with specific properties. Moreover, the nitrogen atom in the pyridine ring enhances the reactivity and regioselectivity of 2-Hydroxypyridine, making it a valuable intermediate in organic synthesis.Furthermore, 2-Hydroxypyridine exhibits coordination properties, enabling its use as a ligand in coordination chemistry and catalysis. Its ability to complex with metal ions opens up opportunities for the synthesis of metal complexes with tailored properties for various applications. Additionally, 2-Hydroxypyridine derivatives have been studied for their potential antimicrobial, antiviral, and anti-inflammatory activities, highlighting the diverse pharmacological applications of this compound.

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• Ring nitrogen-substituted non-steroidal estrogens: pyridine and pyrimidine analogs of the phenol in deoxyhexestrol experience resonance constraints on preferred ligand conformation.

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• A new color of the synthetic chameleon methoxyallene: synthesis of trifluoromethyl-substituted pyridinol derivatives: an unusual reaction mechanism, a remarkable crystal packing, and first palladium-catalyzed coupling reactions.

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  European journal of medicinal chemistry 20040801

• 3-hydroxypyridine chromophores are endogenous sensitizers of photooxidative stress in human skin cells.

  The Journal of biological chemistry 20040716

• Inhibitory effect of pyridyloxy- or phenoxylphenoxyalkanate derivatives on rat lens aldose reductase and rat platelet aggregation.

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• Biradicals/zwitterions from thermolysis of enyne-isocyanates. Application to the synthesis of 2(1H)-pyridones, benzofuro[3,2-c]pyridin-1(2H)-ones, 2,5-dihydro-1H-pyrido[4,3-b]indol-1-ones, and related compounds.

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• Theoretical study of the ruthenium-catalyzed cyclocotrimerization of alkynes with isocyanates and iothiocyanates: cemoselective formation of pyridine-2-one and thiopyrane-2-imine.

  The Journal of organic chemistry 20031031

• Design, synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors.

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• A flexible approach toward trisubstituted piperidines and indolizidines: synthesis of 6-epi-indolizidine 223A.

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• Stable oligonucleotide-directed triplex formation at target sites with CG interruptions: strong sequence-specific recognition by 2',4'-bridged nucleic-acid-containing 2-pyridones under physiological conditions.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20021018

• X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.

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• Unprecedented oxidation of a phenylglycinol-derived 2-pyridone: enantioselective synthesis of polyhydroxypiperidines.

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• Synthesis of 6-(2-thienyl)purine nucleoside derivatives that form unnatural base pairs with pyridin-2-one nucleosides.

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• Cytotoxicity of 2-aldo- and 2-ketopyridine-N(4)-substituted thiosemicarbazones and mode of action in human Tmolt4 cells.

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• Solid-state structure and solution behavior of eight-coordinate Sm(III) poly(pyrazolyl)borate compounds.

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• A short stereoselective preparation of dienamides from cyclobutene compounds. Application in the synthesis of a new cyclohexene nucleoside.

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• Oxodesmosine and isooxodesmosine, candidates of oxidative metabolic intermediates of pyridinium cross-links in elastin.

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  Nucleosides, nucleotides & nucleic acids 20010101

• Substitution mode of the amide fragment in some new N-[omega-[4-(2-methoxyphenyl)piperazin-1-yl]alkyl]pyrid-2(1H)-ones and their 5-HT1A/5-HT2A activity.

  Polish journal of pharmacology 20010101

• Triplex formation involving 2',4'-BNA with 2-pyridone base analogue: efficient and selective recognition of C:G interruption.

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• Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues.

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• 2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.

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