1421-65-4 | L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
5g	95%	in stock	$13.00	$9.00
10g	95%	in stock	$25.00	$17.00
25g	95%	in stock	$60.00	$42.00
100g	95%	in stock	$235.00	$164.00

Description

• Catalog Number: AA69534
• Chemical Name: L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride
• CAS Number: 1421-65-4
• Molecular Formula: C10H14ClNO4
• Molecular Weight: 247.6755
• MDL Number: MFCD00038958
• SMILES: COC(=O)[C@H](Cc1ccc(c(c1)O)O)N.Cl

Computed Properties

• Complexity: 222
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 4

Literature

• Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats.

  International journal of nanomedicine 20120101

• Sustained-release formulation of levodopa methyl ester/benserazide for prolonged suppressing dyskinesia expression in 6-OHDA-leisoned rats.

  Neuroscience letters 20110915

• Daily motor performance after switching levodopa to melevodopa: an open-label on advanced Parkinson's disease with 'delayed-on' and/or'wearing-off'.

  Minerva medica 20110401

• Melevodopa/carbidopa effervescent formulation in the treatment of motor fluctuations in advanced Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20100915

• N-acetyl-L-methionyl-L-Dopa-methyl ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity.

  Free radical biology & medicine 20100701

• A feasibility study of differential delivery of levodopa ester and benserazide using site-specific intestinal loops in rats.

  Journal of pharmaceutical sciences 20100101

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• Biperiden enhances L-DOPA methyl ester and dopamine D(l) receptor agonist SKF-82958 but antagonizes D(2)/D(3) receptor agonist rotigotine antihemiparkinsonian actions.

  European journal of pharmacology 20081203

• L-dopa modulates motor cortex excitability in Alzheimer's disease patients.

  Journal of neural transmission (Vienna, Austria : 1996) 20080901

• Clinical efficacy of a single afternoon dose of effervescent levodopa-carbidopa preparation (CHF 1512) in fluctuating Parkinson disease.

  Clinical neuropharmacology 20070101

• Determination, purity assessment and chiral separation of levodopa methyl ester in bulk and formulation pharmaceuticals.

  Biomedical chromatography : BMC 20060901

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Determination of levodopa methyl ester and its metabolites in rat serum by CZE with amperometric detection.

  Analytical and bioanalytical chemistry 20050501

• Effects of (+/-)-idazoxan alone and in combination with L-DOPA methyl ester in MPTP-induced hemiparkinsonian monkeys.

  Receptors & channels 20030101

• Kinetic characterisation of the reaction mechanism of mushroom tyrosinase on tyramine/dopamine and L-tyrosine methyl esther/L-dopa methyl esther.

  The international journal of biochemistry & cell biology 20021201

• Opposite modulation of regulators of G protein signalling-2 RGS2 and RGS4 expression by dopamine receptors in the rat striatum.

  Neuroscience letters 20021122

• Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20021115

• Influence of layer position on in vitro and in vivo release of levodopa methyl ester and carbidopa from three-layer matrix tablets.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020301

• Effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-OHDA lesions.

  Life sciences 20020118