1421373-66-1 | Azd-9291 mesylate

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$20.00	$14.00
5mg	98%	in stock	$29.00	$20.00
10mg	98%	in stock	$36.00	$25.00
50mg	98%	in stock	$55.00	$38.00
100mg	98%	in stock	$68.00	$47.00
250mg	98%	in stock	$113.00	$79.00
1g	98%	in stock	$248.00	$173.00
5g	98%	in stock	$736.00	$515.00
25g	98%	in stock	$2,582.00	$1,807.00

Description

• Catalog Number: AB51648
• Chemical Name: Azd-9291 mesylate
• CAS Number: 1421373-66-1
• Molecular Formula: C29H37N7O5S
• Molecular Weight: 595.7129800000001
• MDL Number: MFCD28137994
• SMILES: CS(=O)(=O)O.C=CC(=O)Nc1cc(Nc2nccc(n2)c2cn(c3c2cccc3)C)c(cc1N(CCN(C)C)C)OC

Computed Properties

• Complexity: 845
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 42
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 10

Literature

• Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes.

  Toxicology letters 20180701

• Osimertinib induces autophagy and apoptosis via reactive oxygen species generation in non-small cell lung cancer cells.

  Toxicology and applied pharmacology 20170415

• Osimertinib: First Global Approval.

  Drugs 20160201

• Third-generation inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer.

  Journal of hematology & oncology 20160101