142880-36-2 | Ilomastat

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$26.00	$18.00
2mg	98%	in stock	$33.00	$23.00
5mg	98%	in stock	$44.00	$31.00
10mg	98%	in stock	$67.00	$47.00
50mg	98%	in stock	$207.00	$145.00
100mg	98%	in stock	$330.00	$231.00

Description

• Catalog Number: AB46264
• Chemical Name: Ilomastat
• CAS Number: 142880-36-2
• Molecular Formula: C20H28N4O4
• Molecular Weight: 388.4607
• MDL Number: MFCD00917040
• SMILES: ONC(=O)C[C@H](C(=O)N[C@H](C(=O)NC)Cc1c[nH]c2c1cccc2)CC(C)C
• NSC Number: 727632

Computed Properties

• Complexity: 554
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 5
• Rotatable Bond Count: 9
• XLogP3: 0.9

Literature

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  Toxicology and applied pharmacology 20160401

• Bisphenol A and Related Alkylphenols Exert Nongenomic Estrogenic Actions Through a G Protein-Coupled Estrogen Receptor 1 (Gper)/Epidermal Growth Factor Receptor (Egfr) Pathway to Inhibit Meiotic Maturation of Zebrafish Oocytes.

  Biology of reproduction 20151201

• Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles.

  Respiratory research 20140101

• Action of hexachlorobenzene on tumor growth and metastasis in different experimental models.

  Toxicology and applied pharmacology 20130501

• Amyloid-β-induced matrix metalloproteinase-9 secretion is associated with retinal pigment epithelial barrier disruption.

  International journal of molecular medicine 20130501

• Characterisation of acetylcholinesterase release from neuronal cells.

  Chemico-biological interactions 20130325

• Proteolysis controls endogenous substance P levels.

  PloS one 20130101

• Extra- and intracellular imaging of human matrix metalloprotease 11 (hMMP-11) with a cell-penetrating FRET substrate.

  The Journal of biological chemistry 20121102

• Integrin β8 signaling in neonatal hypoxic-ischemic brain injury.

  Neurotoxicity research 20121101

• Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells.

  Oncology reports 20121101

• Suppression of tunicamycin-induced CD44v6 ectodomain shedding and apoptosis is correlated with temporal expression patterns of active ADAM10, MMP-9 and MMP-13 proteins in Caki-2 renal carcinoma cells.

  Oncology reports 20121101

• Changes in mitochondrial DNA alter expression of nuclear encoded genes associated with tumorigenesis.

  Experimental cell research 20121015

• Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells.

  Archives of toxicology 20121001

• Novel sonomicrometry of ex vivo diaphragm after phrenic nerve injury: Role of matrix metalloproteinases.

  Synapse (New York, N.Y.) 20120801

• Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways.

  British journal of pharmacology 20120701

• Increased expression of matrix metalloproteinases mediates thromboxane A2-induced invasion in lung cancer cells.

  Current cancer drug targets 20120701

• Aβ₁₋₄₂-RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca²⁺-calcineurin signaling.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120627

• Metalloproteinases regulate CD40L shedding from platelets and pulmonary recruitment of neutrophils in abdominal sepsis.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120601

• Effects of MMP inhibitors incorporated within dental adhesives.

  Journal of dental research 20120601

• Involvement of matrix metalloproteinase-9 in the development of morphine tolerance.

  European journal of pharmacology 20120515

• Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury.

  Glia 20120501

• Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.

  Matrix biology : journal of the International Society for Matrix Biology 20120501

• Porphyromonas gingivalis promotes monocyte migration by activating MMP-9.

  Journal of periodontal research 20120401

• A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases.

  American journal of physiology. Cell physiology 20120215

• A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

  Toxicology and applied pharmacology 20120115

• Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism.

  Neuroscience 20120103

• Permissive effect of EGFR-activated pathways on RVI and their anti-apoptotic effect in hypertonicity-exposed mIMCD3 cells.

  Bioscience reports 20111201

• The anti-invasive activity of synthetic alkaloid ethoxyfagaronine on L1210 leukemia cells is mediated by down-regulation of plasminogen activators and MT1-MMP expression and activity.

  Investigational new drugs 20111001

• Doxycycline could aggravate the absence-like epileptic seizures of WAG/Rij rats via matrix metalloproteinase inhibition.

  Neurochemistry international 20111001

• ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells.

  Stem cells (Dayton, Ohio) 20111001

• Zinc-triggered induction of tissue plasminogen activator by brain-derived neurotrophic factor and metalloproteinases.

  Journal of neurochemistry 20110901

• Inhibition of MMPs by alcohols.

  Dental materials : official publication of the Academy of Dental Materials 20110901

• Non-coding nucleotides and amino acids near the active site regulate peptide deformylase expression and inhibitor susceptibility in Chlamydia trachomatis.

  Microbiology (Reading, England) 20110901

• Interleukin-lβ induces migration of rat arterial smooth muscle cells through a mechanism involving increased matrix metalloproteinase-2 activity.

  The Journal of surgical research 20110801

• Methamphetamine-associated cleavage of the synaptic adhesion molecule intercellular adhesion molecule-5.

  Journal of neurochemistry 20110801

• Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.

  Journal of medicinal chemistry 20110714

• Advancing the treatment of conjunctival scarring: a novel ex vivo model.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20110501

• Fluoride does not inhibit enamel protease activity.

  Journal of dental research 20110401

• LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells.

  Molecular cancer 20110101

• Calpain activator dibucaine induces platelet apoptosis.

  International journal of molecular sciences 20110101

• Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins.

  PloS one 20110101

• Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin.

  Stem cell research & therapy 20110101

• Inhibition of matrix metalloproteinases in Siberian hamsters impedes photostimulated recrudescence of ovaries.

  Reproduction (Cambridge, England) 20101201

• Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo.

  Neurochemistry international 20101101

• Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors.

  Neurochemistry international 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Stromal remodelling is required for progressive involution of the rat ventral prostate after castration: identification of a matrix metalloproteinase-dependent apoptotic wave.

  International journal of andrology 20101001

• Ovarian steroids, mitogen-activated protein kinases, and/or aspartic proteinases cooperate to control endometrial remodeling by regulating gene expression in the stroma and glands.

  Endocrinology 20100901

• Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1.

  Cancer research 20100901

• Matrix metalloproteinase-9 is upregulated in nucleophosmin-anaplastic lymphoma kinase-positive anaplastic lymphomas and activated at the cell surface by the chaperone heat shock protein 90 to promote cell invasion.

  Cancer research 20100901

• Regulation of the blood-brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitro.

  Brain research 20100806

• Enhanced matrix metalloproteinase activity in the spontaneously hypertensive rat: VEGFR-2 cleavage, endothelial apoptosis, and capillary rarefaction.

  Journal of vascular research 20100801

• Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo.

  Glycoconjugate journal 20100801

• Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells.

  FEBS letters 20100702

• Thromboxane prostanoid receptor stimulation induces shedding of the transmembrane chemokine CX3CL1 yet enhances CX3CL1-dependent leukocyte adhesion.

  American journal of physiology. Cell physiology 20100601

• Use of a specific MMP-inhibitor (galardin) for preservation of hybrid layer.

  Dental materials : official publication of the Academy of Dental Materials 20100601

• Induction of CD44 cleavage in articular chondrocytes.

  Arthritis and rheumatism 20100501

• Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP.

  International journal of oncology 20100401

• Matrix metalloproteinase inhibition enhances the rate of nerve regeneration in vivo by promoting dedifferentiation and mitosis of supporting schwann cells.

  Journal of neuropathology and experimental neurology 20100401

• The role of calpain in the regulation of ADAM17-dependent GPIbalpha ectodomain shedding.

  Archives of biochemistry and biophysics 20100315

• Cholesterol efflux stimulates metalloproteinase-mediated cleavage of occludin and release of extracellular membrane particles containing its C-terminal fragments.

  Experimental cell research 20100201

• ATP induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9.

  Archives of pharmacal research 20100201

• Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc(-).

  Toxicology and applied pharmacology 20100115

• Three-dimensional cell culture array using magnetic force-based cell patterning for analysis of invasive capacity of BALB/3T3/v-src.

  Lab on a chip 20091207

• ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors.

  Neurochemistry international 20091201

• Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production.

  American journal of respiratory and critical care medicine 20091101

• Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation.

  Psychopharmacology 20091101

• Analysis of gene expression in PTHrP-/- mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis.

  Developmental dynamics : an official publication of the American Association of Anatomists 20091101

• Altered expression of glycoproteins on the cell surface of Jurkat cells during etoposide-induced apoptosis: shedding and intracellular translocation of glycoproteins.

  Biochimica et biophysica acta 20091001

• Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.

  Journal of medicinal chemistry 20090924

• Evaluation of protease inhibitors and an antioxidant for treatment of sulfur mustard-induced toxic lung injury.

  Toxicology 20090901

• In vitro and ex vivo activity of peptide deformylase inhibitors against Mycobacterium tuberculosis H37Rv.

  International journal of antimicrobial agents 20090901

• A protease inhibitor discovery method using fluorescence correlation spectroscopy with position-specific labeled protein substrates.

  Analytical biochemistry 20090715

• Transmural pressure and axial loading interactively regulate arterial remodeling ex vivo.

  American journal of physiology. Heart and circulatory physiology 20090701

• Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus.

  Clinical orthopaedics and related research 20090601

• Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice.

  Journal of neurochemistry 20090601

• Prolonged inhibition of protein kinase A results in metalloproteinase-dependent platelet GPIbalpha shedding.

  Thrombosis research 20090501

• Secreted cysteine-rich FGF receptor derives from posttranslational processing by furin-like prohormone convertases.

  Biochemical and biophysical research communications 20090501

• Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism.

  Journal of vascular surgery 20090501

• Nonlinear optical microscopy reveals invading endothelial cells anisotropically alter three-dimensional collagen matrices.

  Experimental cell research 20090201

• Activated human neutrophils rapidly release the chemotactically active D2D3 form of the urokinase-type plasminogen activator receptor (uPAR/CD87).

  Molecular and cellular biochemistry 20090101

• Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein.

  Journal of immunology (Baltimore, Md. : 1950) 20090101

• Expression profiles of matrix metalloproteinase 9 in teleost fish provide evidence for its active role in initiation and resolution of inflammation.

  Immunology 20081201

• Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation.

  Psychopharmacology 20081201

• Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z.

  The Journal of biological chemistry 20081107

• Protective effect of ilomastat on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats.

  World journal of gastroenterology 20081007

• Matrix metalloproteinase 2 improves the transplanted adipocyte survival in mice.

  European journal of clinical investigation 20081001

• Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.

  Proceedings of the National Academy of Sciences of the United States of America 20080923

• Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity.

  Bioorganic & medicinal chemistry 20080915

• Gamma-secretase and metalloproteinase activity regulate the distribution of endoplasmic reticulum to hippocampal neuron dendritic spines.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080801

• Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia.

  American journal of physiology. Heart and circulatory physiology 20080801

• Insulin-induced epidermal growth factor activation in vascular smooth muscle cells is ADAM-dependent.

  Surgery 20080801

• Latanoprost-induced changes in rat intraocular pressure: direct or indirect?

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080801

• The effect of therapeutic human serum drops on corneal stromal wound-healing activity.

  Current eye research 20080801

• Macrophages regulate tumor necrosis factor-alpha expression in adipocytes through the secretion of matrix metalloproteinase-3.

  International journal of obesity (2005) 20080601

• Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.

  American journal of respiratory cell and molecular biology 20080401

• Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway.

  Molecular endocrinology (Baltimore, Md.) 20080401

• The highly specific platelet glycoprotein (GP) VI agonist trowaglerix impaired collagen-induced platelet aggregation ex vivo through matrix metalloproteinase-dependent GPVI shedding.

  Journal of thrombosis and haemostasis : JTH 20080401

• [Study on inhibitory effects of matrix metalloproteinase inhibitor on migration of cultured human lens epithelial cells].

  [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20080401

• Endothelial dependence of matrix metalloproteinase-mediated vascular hyporeactivity caused by lipopolysaccharide.

  European journal of pharmacology 20080317

• Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells.

  American journal of physiology. Renal physiology 20080301

• Human T cells stimulate fibroblast-mediated degradation of extracellular matrix in vitro.

  Clinical and experimental immunology 20080201

• Characterization of the cell membrane-associated products of the Neuregulin 4 gene.

  Oncogene 20080124

• Potential protective effect of fresh grown unicellular green algae component (resilient factor) against PMA- and UVB-induced MMP1 expression in skin fibroblasts.

  European journal of dermatology : EJD 20080101

• Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function.

  Journal of cellular physiology 20071201

• Rapid determination of enzyme kinetics from fluorescence: overcoming the inner filter effect.

  Analytical biochemistry 20071201

• VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.

  Arteriosclerosis, thrombosis, and vascular biology 20071201

• Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.

  European journal of pharmacology 20071114

• Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

  The Biochemical journal 20071101

• Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane.

  The Journal of biological chemistry 20071019

• Shedding of the urinary biomarker kidney injury molecule-1 (KIM-1) is regulated by MAP kinases and juxtamembrane region.

  Journal of the American Society of Nephrology : JASN 20071001

• Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.

  The Journal of biological chemistry 20070921

• Characterisation of endothelin converting enzyme-1 shedding from endothelial cells.

  FEBS letters 20070918

• Membrane-bound heparin-binding epidermal growth factor like growth factor regulates E-cadherin expression in pancreatic carcinoma cells.

  Cancer research 20070915

• Complex regulation of pulmonary inflammation and fibrosis by CCL18.

  The American journal of pathology 20070801

• Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.

  The Journal of biological chemistry 20070720

• Simultaneous presence of unsaturation and long alkyl chain at P'1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies.

  Bioorganic & medicinal chemistry 20070715

• Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening.

  Analytical biochemistry 20070715

• Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.

  Endocrinology 20070701

• Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases.

  Journal of thrombosis and haemostasis : JTH 20070701

• Depolarization-induced, glutamate receptor-mediated, and transactivation-dependent extracellular-signal regulated kinase phosphorylation in cultured cerebellar granule neurons.

  Neuroscience 20070629

• Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070418

• Protein kinase C activity mediates LH-induced ErbB/Erk signaling in differentiated hen granulosa cells.

  Reproduction (Cambridge, England) 20070401

• Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells.

  American journal of physiology. Renal physiology 20070301

• Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.

  Endocrinology 20070301

• Big ET-1 processing into vasoactive peptides in arteries and veins.

  Vascular pharmacology 20070101

• gamma-Aminbuturic acid A receptor mitigates homocysteine-induced endothelial cell permeability.

  Endothelium : journal of endothelial cell research 20070101

• Methylmercury induces activation of Notch signaling.

  Neurotoxicology 20061201

• Transmigration: a new property of mature multinucleated osteoclasts.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20061201

• Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.

  Endocrine-related cancer 20061201

• Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells.

  American journal of physiology. Cell physiology 20061101

• GnRH actions on rat preovulatory follicles are mediated by paracrine EGF-like factors.

  Molecular reproduction and development 20061001

• Kinin modulation of conventional outflow facility in the bovine eye.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20061001

• Matrix metalloproteinases promote inflammation and fibrosis in asbestos-induced lung injury in mice.

  American journal of respiratory cell and molecular biology 20060901

• TIMP-1/MMP-9 imbalance in brain edema in rats with fulminant hepatic failure.

  The Journal of surgical research 20060801

• Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation.

  Osteoarthritis and cartilage 20060801

• Matrix metalloproteinase inhibition attenuates aortic calcification.

  Arteriosclerosis, thrombosis, and vascular biology 20060701

• Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.

  The EMBO journal 20060621

• Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium.

  The Journal of biological chemistry 20060616

• Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver.

  Journal of leukocyte biology 20060601

• Balamuthia mandrillaris exhibits metalloprotease activities.

  FEMS immunology and medical microbiology 20060601

• Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292.

  Life sciences 20060522

• Lysophosphatidic acid-induced effects in human colon carcinoma DLD1 cells are partially dependent on transactivation of epidermal growth factor receptor.

  The Journal of surgical research 20060501

• Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060501

• Src homology 2-containing phosphotyrosine phosphatase regulates endothelin-1-induced epidermal growth factor receptor transactivation in rat renal tubular cell NRK-52E.

  Pflugers Archiv : European journal of physiology 20060401

• Vascular responses to alpha1-adrenergic receptors in small rat mesenteric arteries depend on mitochondrial reactive oxygen species.

  Arteriosclerosis, thrombosis, and vascular biology 20060401

• PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration.

  Oncology reports 20060401

• The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead platelets.

  Thrombosis and haemostasis 20060101

• NCAM140 stimulates integrin-dependent cell migration by ectodomain shedding.

  Journal of neurochemistry 20051201

• Combining in silico tools and NMR data to validate protein-ligand structural models: application to matrix metalloproteinases.

  Journal of medicinal chemistry 20051201

• Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death.

  Investigative ophthalmology & visual science 20051201

• Filamin is essential for shedding of the transmembrane serine protease, epithin.

  EMBO reports 20051101

• Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats.

  The American journal of pathology 20051101

• Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases.

  The FEBS journal 20051101

• Transactivation of epidermal growth factor receptor is involved in leptin-induced activation of janus-activated kinase 2 and extracellular signal-regulated kinase 1/2 in human gastric cancer cells.

  Cancer research 20051015

• Modulation of conventional outflow facility by the adenosine A1 agonist N6-cyclohexyladenosine.

  Investigative ophthalmology & visual science 20051001

• Matrix metalloproteinases mediate beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes.

  American journal of physiology. Cell physiology 20050701

• Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.

  The Journal of biological chemistry 20050701

• Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib.

  British journal of cancer 20050509

• Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts.

  The Journal of pharmacology and experimental therapeutics 20050301

• Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation.

  American journal of respiratory and critical care medicine 20050215

• Epidermal growth factor family members: endogenous mediators of the ovulatory response.

  Endocrinology 20050101

• Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants.

  Arthritis research & therapy 20050101

• Effect of a matrix metalloproteinase activity and TNF-alpha converting enzyme inhibitor on intra-abdominal adhesions.

  European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20050101

• Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors.

  Bioorganic & medicinal chemistry letters 20041220

• Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes.

  Experimental dermatology 20041201

• Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

  Cancer cell 20041201

• Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.

  Circulation research 20041112

• TIMP-1 stimulates proliferation of human aortic smooth muscle cells and Ras effector pathways.

  Biochemical and biophysical research communications 20041105

• Alpha lipoic acid inhibits human T-cell migration: implications for multiple sclerosis.

  Journal of neuroscience research 20041101

• Down-regulated expression of A disintegrin and metalloproteinase with thrombospondin-like repeats-1 by progesterone receptor antagonist is associated with impaired expansion of porcine cumulus-oocyte complexes.

  Endocrinology 20041001

• Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds.

  Experimental cell research 20041001

• Opioid control of MAP kinase cascade.

  European journal of pharmacology 20041001

• Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells.

  Bioscience, biotechnology, and biochemistry 20041001

• The role of matrix metalloproteinases in vascular function: implications for normal pregnancy and pre-eclampsia.

  BJOG : an international journal of obstetrics and gynaecology 20040901

• Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases.

  Circulation research 20040820

• EGF-Like domain of tenascin-C is proapoptotic for cultured smooth muscle cells.

  Arteriosclerosis, thrombosis, and vascular biology 20040801

• Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19.

  Experimental cell research 20040801

• Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist.

  Journal of immunology (Baltimore, Md. : 1950) 20040801

• Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization.

  Journal of the American College of Cardiology 20040616

• Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.

  American journal of respiratory cell and molecular biology 20040401

• Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface.

  Journal of cell science 20040401

• Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury.

  Arthritis and rheumatism 20040301

• Tissue inhibitor of metalloproteinase-1 stimulates proliferation of human cancer cells by inhibiting a metalloproteinase.

  British journal of cancer 20040126

• Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040121

• Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors.

  Bioorganic & medicinal chemistry letters 20040105

• Ovarian carcinoma spheroids disaggregate on type I collagen and invade live human mesothelial cell monolayers.

  Clinical & experimental metastasis 20040101

• Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries.

  Circulation research 20031212

• Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism.

  Cancer research 20031201

• Galardin (GM 6001), a broad-spectrum matrix metalloproteinase inhibitor, blocks bombesin- and LPA-induced EGF receptor transactivation and DNA synthesis in rat-1 cells.

  Experimental cell research 20031101

• Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration.

  Developmental cell 20031001

• MMPs inhibitors: new succinylhydroxamates with selective inhibition of MMP-2 over MMP-3.

  Bioorganic & medicinal chemistry letters 20030901

• Tamoxifen induces apoptosis in Fas+ tumor cells by upregulating the expression of Fas ligand.

  Cancer chemotherapy and pharmacology 20030401

• Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor.

  Diabetes 20030101

• Establishment of an in vitro assay to measure the invasion of ovarian carcinoma cells through mesothelial cell monolayers.

  Clinical & experimental metastasis 20030101

• Matrix metalloproteinases are not involved in early brain edema formation after cardiac arrest in rats.

  Acta neurochirurgica. Supplement 20030101

• Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process.

  Journal of immunology (Baltimore, Md. : 1950) 20021201

• In vitro migration of melanoblasts requires matrix metalloproteinase-2: implications to vitiligo therapy by photochemotherapy.

  Pigment cell research 20021201

• Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration.

  The Journal of biological chemistry 20021018

• Metalloproteases and guidance of retinal axons in the developing visual system.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020915

• TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity.

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