1436-59-5 | (1R,2S)-Cyclohexane-1,2-diamine

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$6.00	$4.00
5g	95%	in stock	$13.00	$10.00
10g	95%	in stock	$16.00	$12.00
25g	95%	in stock	$36.00	$26.00
100g	95%	in stock	$144.00	$101.00

Description

• Catalog Number: AD18934
• Chemical Name: (1R,2S)-Cyclohexane-1,2-diamine
• CAS Number: 1436-59-5
• Molecular Formula: C6H14N2
• Molecular Weight: 114.1888
• MDL Number: MFCD00063746
• SMILES: N[C@@H]1CCCC[C@@H]1N

Computed Properties

• Complexity: 62.9
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• XLogP3: -0.3

Literature

• A new 'fully reduced' polyoxovanadate constructed from nanosized triangle-shaped [V(III)3V(IV)18P6O60(DACH)3]}9- cluster anions exhibiting ferrimagnetic interactions.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20120917

• Antitumor platinum(II) complexes of N-monoalkyl-1R, 2R-diaminocyclohexane derivatives with alkyl groups as hindrance.

  Journal of inorganic biochemistry 20120701

• Stereoselective UV sensing of 1,2-diaminocyclohexane isomers based on ligand displacement with a diacridylnaphthalene N,N'-dioxide scandium complex.

  The Journal of organic chemistry 20120601

• Diastereoselective imine-bond formation through complementary double-helix formation.

  Journal of the American Chemical Society 20120502

• Synthesis, in vitro cytotoxicity, and interaction with DNA of platinum(II) complexes with N-monocycloalkyl derivatives of 1R,2R-diaminocyclohexane as carrier ligands.

  ChemMedChem 20120401

• trans-1,2-Diaminocyclohexane mesoporous silica for asymmetric catalysis: enhancement of chirality through confinement space by the plug effect.

  Chemical communications (Cambridge, England) 20120325

• Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles.

  Chemotherapy research and practice 20120101

• Steric modifications tune the regioselectivity of the alkane oxidation catalyzed by non-heme iron complexes.

  Inorganic chemistry 20111219

• Interactions of an asymmetric amine with a non-C2 symmetric Cu-salen complex: an EPR/ENDOR and HYSCORE investigation.

  Physical chemistry chemical physics : PCCP 20111207

• Chiral diaminopyrrolic receptors for selective recognition of mannosides, part 1: design, synthesis, and affinities of second-generation tripodal receptors.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110418

• A mechanistic approach for the DNA binding of chiral enantiomeric L- and D-tryptophan-derived metal complexes of 1,2-DACH: cleavage and antitumor activity.

  Chirality 20110301

• Oligopyrenotides: abiotic, polyanionic oligomers with nucleic acid-like structural properties.

  Journal of the American Chemical Society 20100602

• Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties.

  Bioorganic & medicinal chemistry 20091215

• Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.

  Bioorganic & medicinal chemistry 20091215

• Synthesis, spectroscopic, structural characterization, electrochemical and antimicrobial activity studies of the Schiff base ligand and its transition metal complexes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20091015

• Critical role of external axial ligands in chirality amplification of trans-cyclohexane-1,2-diamine in salen complexes.

  Journal of the American Chemical Society 20090902

• Quantification of trace elements in natural samples by electrospray ionization mass spectrometry with a size-exclusion column based on the formation of metal-aminopolycarboxylate complexes.

  Analytical chemistry 20090801

• Simple cyclohexanediamine-derived primary amine thiourea catalyzed highly enantioselective conjugate addition of nitroalkanes to enones.

  Organic letters 20090702

• Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics.

  Bioorganic & medicinal chemistry 20080801

• Synthesis and antiviral activities of N-mono- and/or N,N'-di-carbamoyl and acyl derivatives of symmetrical diamines.

  Chemical & pharmaceutical bulletin 20080701

• Instantaneous low temperature gelation by a multicomponent organogelator liquid system based on ammonium salts.

  Journal of the American Chemical Society 20080625

• Trans-cyclohexanediamines prevent thermal inactivation of protein: role of hydrophobic and electrostatic interactions.

  The protein journal 20080601

• Discrimination of enantiomers of alpha-amino acids by chiral derivatizing reagents from trans-1,2-diaminocyclohexane.

  Chirality 20080301

• Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• N-monocarbamoyl derivatives of symmetrical diamines with antiviral activity.

  Chemical & pharmaceutical bulletin 20070901

• Dinuclear platinum complexes with biological relevance based on the 1,2-diaminocyclohexane carrier ligand.

  Inorganic chemistry 20070723

• Enantioselective fluorescent recognition of chiral acids by cyclohexane-1,2-diamine-based bisbinaphthyl molecules.

  The Journal of organic chemistry 20070622

• The impact of different chelating leaving groups on the substitution kinetics of mononuclear Pt(II)(1,2-trans-R,R-diaminocyclohexane)(X-Y) complexes.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070501

• A glucose derivative as natural alternative to the cyclohexane-1,2-diamine ligand in the anticancer drug oxaliplatin?

  ChemMedChem 20070401

• Asymmetric amplification in catalysis by trans-1,2-diaminocyclohexane bistriflamide.

  Organic letters 20070118

• Review of the toxicology of three alkyl diamines.

  Drug and chemical toxicology 20070101

• Chiral macrocyclic aliphatic oligoimines derived from trans-1,2-diaminocyclohexane.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• Flexibility of inorganic tennis ball structures inducing anion selectivity.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20060918

• Asymmetric transfer hydrogenation catalysed by hydrophobic dendritic DACH-rhodium complex in water.

  Organic & biomolecular chemistry 20060907

• Pyrromethene dyes (BODIPY) can form ground state homo and hetero dimers: photophysics and spectral properties.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060901

• Luminescent amidate-bridged one-dimensional platinum(II)-thallium(I) coordination polymers assembled via metallophilic attraction.

  Inorganic chemistry 20060710

• Racemic N-aryl bis(amidines) and bis(amidinates): on the trail of enantioselective organolanthanide catalysts.

  Dalton transactions (Cambridge, England : 2003) 20060328

• Anticancer activity of a series of platinum complexes integrating demethylcantharidin with isomers of 1,2-diaminocyclohexane.

  Bioorganic & medicinal chemistry letters 20060315

• Determination of different classes of amines with capillary zone electrophoresis and contactless conductivity detection.

  Electrophoresis 20060201

• Lanthanide complexes of chiral 3 + 3 macrocycles derived from (1R,2R)-1,2-diaminocyclohexane and 2,6-diformyl-4-methylphenol.

  Dalton transactions (Cambridge, England : 2003) 20060114

• Rhombimines-cyclic tetraimines of trans-1,2-diaminocyclohexane shaped by the diaryl ether structural motif.

  The Journal of organic chemistry 20051125

• New 2+2, 3+3 and 4+4 macrocycles derived from 1,2-diaminocyclohexane and 2,6-diformylpyridine.

  Organic & biomolecular chemistry 20050907

• Colorimetric enantiodiscrimination of alpha-amino acids in protic media.

  Journal of the American Chemical Society 20050608

• Shape-complementarity in the recognition of tricarboxylic acids by a [3+3] polyazacyclophane receptor.

  The Journal of organic chemistry 20050318

• Chromatographic evaluation of poly (trans-1,2-cyclohexanediyl-bis acrylamide) as a chiral stationary phase for HPLC.

  Journal of chromatography. A 20050225

• Kinetic resolution of amines: a highly enantioselective and chemoselective acetylating agent with a unique solvent-induced reversal of stereoselectivity.

  Angewandte Chemie (International ed. in English) 20040621

• Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability.

  European journal of medicinal chemistry 20040501

• X-ray structure and circular dichroism of pure rotamers of bis[guanosine-5'-monophosphate(-1)](N,N,N',N'-tetramethylcyclohexyl-1,2-diamine)platinum(II) complexes that have R,R and S,S configurations at the asymmetric diamine.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20031215

• Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phosphonomethyl)glycine ligand.

  Journal of medicinal chemistry 20031106

• A metal-centered hydrophobic pocket recognizing pyridine over piperidine.

  Journal of the American Chemical Society 20030618

• Nitrogen lone pair interactions in organic molecules: a photoelectron spectroscopic study.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030601

• Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates.

  European journal of medicinal chemistry 20030101

• Occupational contact sensitization to 1,2-diaminocyclohexane.

  Contact dermatitis 20010801

• The in vitro antitumour profile of some 1,2-diaminocyclohexane organotin complexes.

  Journal of inorganic biochemistry 20010115

• [Oxaliplatin: preclinical in vitro studies].

  Tumori 20010101