1446144-04-2 | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$30.00	$21.00
2mg	98%	in stock	$42.00	$29.00
5mg	98%	in stock	$58.00	$40.00
10mg	98%	in stock	$82.00	$57.00
25mg	98%	in stock	$153.00	$107.00

Description

• Catalog Number: AA72181
• Chemical Name: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-
• CAS Number: 1446144-04-2
• Molecular Formula: C19H18ClN5OS
• Molecular Weight: 399.8971
• MDL Number: MFCD27997886
• SMILES: NC(=O)C[C@@H]1N=C(c2ccc(cc2)Cl)c2c(-n3c1nnc3C)sc(c2C)C

Computed Properties

• Complexity: 611
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 2.9

Literature

• Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma.

  Leukemia 20141001

• The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors.

  Cell death & disease 20141001

• Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors.

  Proceedings of the National Academy of Sciences of the United States of America 20140805

• BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain.

  Proceedings of the National Academy of Sciences of the United States of America 20120501