1448347-49-6 | AG-120

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$8.00	$6.00
5mg	95%	in stock	$13.00	$9.00
10mg	95%	in stock	$20.00	$14.00
50mg	95%	in stock	$47.00	$33.00
100mg	95%	in stock	$76.00	$53.00
250mg	95%	in stock	$127.00	$89.00
1g	95%	in stock	$342.00	$239.00
5g	95%	in stock	$1,605.00	$1,123.00

Description

• Catalog Number: AE81483
• Chemical Name: AG-120
• CAS Number: 1448347-49-6
• Molecular Formula: C28H22ClF3N6O3
• Molecular Weight: 582.9609
• MDL Number: MFCD29036964
• SMILES: N#Cc1ccnc(c1)N1C(=O)CC[C@H]1C(=O)N([C@@H](c1ccccc1Cl)C(=O)NC1CC(C1)(F)F)c1cncc(c1)F

Computed Properties

• Complexity: 1050
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 41
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 7
• XLogP3: 3.4

Literature

• Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML.

  The New England journal of medicine 20180621

• Evidence for Clinical Differentiation and Differentiation Syndrome in Patients With Acute Myeloid Leukemia and IDH1 Mutations Treated With the Targeted Mutant IDH1 Inhibitor, AG-120.

  Clinical lymphoma, myeloma & leukemia 20160801

• Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

  Nature 20091210