145-13-1 | Pregnenolone

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$8.00	$5.00
5g	98%	in stock	$15.00	$10.00
10g	98%	in stock	$28.00	$19.00
25g	98%	in stock	$29.00	$20.00
100g	98%	in stock	$97.00	$68.00
500g	98%	in stock	$408.00	$285.00

Description

• Catalog Number: AB78591
• Chemical Name: Pregnenolone
• CAS Number: 145-13-1
• Molecular Formula: C21H32O2
• Molecular Weight: 316.4776
• MDL Number: MFCD00003628
• SMILES: O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2C(=O)C)C)C1)C

Computed Properties

• Complexity: 550
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 7
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 4.2

Literature

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  Clinical endocrinology 20120601

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• Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats.

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  The Journal of biological chemistry 20120518

• Identification and characterization of zebrafish SULT1 ST9, SULT3 ST4, and SULT3 ST5.

  Aquatic toxicology (Amsterdam, Netherlands) 20120515

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  Toxicology and applied pharmacology 20120515

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  Journal of medicinal chemistry 20120510

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• Allopregnanolone infused into the dorsal (CA1) hippocampus increases prepulse inhibition of startle response in Wistar rats.

  Psychoneuroendocrinology 20120401

• A history of depression in women is associated with an altered GABAergic neuroactive steroid profile.

  Psychoneuroendocrinology 20120401

• High levels of corticosterone, and gene expression of star, cyp17a2, hsd3b, cyp21, hsd11b2 during acute stress in common carp with interrenal hyperplasia.

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  PloS one 20120101

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  Acta neurobiologiae experimentalis 20120101

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  The open biochemistry journal 20120101

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• Mechanism of phytoestrogen action in Leydig cells of ganders (Anser anser domesticus): Interaction with estrogen receptors and steroidogenic enzymes.

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  PloS one 20120101

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  Frontiers in immunology 20120101

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  PloS one 20120101

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  Journal of pharmacological sciences 20120101

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  Biochemistry 20111227

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  Molecules (Basel, Switzerland) 20111202

• Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival.

  Age (Dordrecht, Netherlands) 20111201

• Chronic administration of the anabolic androgenic steroid nandrolone alters neurosteroid action at the sigma-1 receptor but not at the sigma-2 or NMDA receptors.

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  Molecular pharmacology 20111201

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  Journal of lipid research 20111201

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  Toxicology letters 20111130

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  The Journal of biological chemistry 20111111

• Fast and sensitive liquid chromatography-mass spectrometry assay for seven androgenic and progestagenic steroids in human serum.

  The Journal of steroid biochemistry and molecular biology 20111101

• Benzo[a]pyrene reduces testosterone production in rat Leydig cells via a direct disturbance of testicular steroidogenic machinery.

  Environmental health perspectives 20111101

• Hydroxylation of steroids by Fusarium oxysporum, Exophiala jeanselmei and Ceratocystis paradoxa.

  Steroids 20111101

• Synthesis and antimicrobial studies of chalconyl pregnenolones.

  Steroids 20111101

• Inhibitory effect of 5β-pregnane-3α,20β-diol on transcriptional activity and enzyme activity of human bilirubin UDP-glucuronosyltransferase.

  Pediatric research 20111101

• Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20111101

• High allele frequency of the p.Q258X mutation and identification of a novel mis-splicing mutation in the STAR gene in Korean patients with congenital lipoid adrenal hyperplasia.

  European journal of endocrinology 20111101

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  The Journal of clinical endocrinology and metabolism 20111101

• A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons.

  Journal of neurochemistry 20111101

• Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats.

  Journal of neurochemistry 20111101

• Immunohistochemical evidence: testicular and scented glandular androgen synthesis in muskrats (Ondatra zibethicus) during the breeding season.

  European journal of histochemistry : EJH 20111019

• Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors.

  Cancer research 20111015

• Changes in functioning of mesolimbic incentive processing circuits during the premenstrual phase.

  Social cognitive and affective neuroscience 20111001

• The FGIN period: electrophysiological studies.

  Pharmacological research 20111001

• Mineralocorticoid hypertension.

  Indian journal of endocrinology and metabolism 20111001

• Pediatric endocrine hypertension.

  Indian journal of endocrinology and metabolism 20111001

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  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20111001

• Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs?

  Neuroscience 20110915

• The clinical and therapeutic potentials of dehydroepiandrosterone and pregnenolone in schizophrenia.

  Neuroscience 20110915

• Neuroactive steroids in periphery and cerebrospinal fluid.

  Neuroscience 20110915

• Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.

  Neuroscience 20110915

• Neurosteroids infusion into the CA1 hippocampal region on exploration, anxiety-like behaviour and aversive learning.

  Behavioural brain research 20110912

• Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPARα.

  Toxicology letters 20110910

• Differential modulation of the glutamate-nitric oxide-cyclic GMP pathway by distinct neurosteroids in cerebellum in vivo.

  Neuroscience 20110908

• Hydrophobic anions potently and uncompetitively antagonize GABA(A) receptor function in the absence of a conventional binding site.

  British journal of pharmacology 20110901

• Effects of nonylphenol on the production of progesterone on the rats granulosa cells.

  Journal of cellular biochemistry 20110901

• Influence of gender, feeding regimen, and exposure duration on gene expression associated with xenobiotic metabolism in fathead minnows (Pimephales promelas).

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20110901

• 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress.

  Frontiers in neuroendocrinology 20110801

• Decreased cytochrome c oxidase IV expression reduces steroidogenesis.

  The Journal of pharmacology and experimental therapeutics 20110801

• Effects of polybrominated diphenyl ethers on steroidogenesis in rat Leydig cells.

  Human reproduction (Oxford, England) 20110801

• Treatment of experimental spinal cord injury with 3β-methoxy-pregnenolone.

  Brain research 20110727

• The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility.

  Molecular endocrinology (Baltimore, Md.) 20110701

• Determination of steroid hormones in blood by GC-MS/MS.

  Analytical and bioanalytical chemistry 20110701

• Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish.

  Journal of lipid research 20110701

• Activity and expression of steroidogenic enzymes in the brain of adult zebrafish.

  The European journal of neuroscience 20110701

• Limited expression of cytochrome p450 17α-hydroxylase/17,20-lyase in prostate cancer cell lines.

  Korean journal of urology 20110701

• The truth about false unicorn (Chamaelirium luteum): total synthesis of 23R,24S-chiograsterol B defines the structure and stereochemistry of the major saponins from this medicinal herb.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110627

• Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor.

  Molecular pharmacology 20110601

• Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20110601

• Species-specific sensitivity to selenium-induced impairment of cortisol secretion in adrenocortical cells of rainbow trout (Oncorhynchus mykiss) and brook trout (Salvelinus fontinalis).

  Toxicology and applied pharmacology 20110601

• A family with autism and rare copy number variants disrupting the Duchenne/Becker muscular dystrophy gene DMD and TRPM3.

  Journal of neurodevelopmental disorders 20110601

• A preliminary study on progesterone antioxidation in promoting learning and memory of young ovariectomized mice.

  Archives of medical science : AMS 20110601

• 3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition.

  Toxicology letters 20110530

• Cytotoxic and PPARs transcriptional activities of sterols from the Vietnamese soft coral Lobophytum laevigatum.

  Bioorganic & medicinal chemistry letters 20110515

• TRPM3 is a nociceptor channel involved in the detection of noxious heat.

  Neuron 20110512

• Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABAA receptor activity.

  Psychoneuroendocrinology 20110501

• Immunohistochemical localisation and molecular expression of the steroidogenic enzyme cytochrome P450 17α-hydroxylase /C(17,20)-lyase in the vestibular nuclei of adult male rats.

  Journal of neuroendocrinology 20110501

• Investigations on changes in ¹³C/¹²C ratios of endogenous urinary steroids after pregnenolone administration.

  Drug testing and analysis 20110501

• Evaluation of the interaction of coumarins with biomembrane models studied by differential scanning calorimetry and Langmuir-Blodgett techniques.

  Journal of natural products 20110425

• Aza-annulation on the 16-dehydropregnenolone, via tandem intermolecular aldol process and intramolecular Michael addition.

  Bioorganic & medicinal chemistry letters 20110415

• Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels in vivo and in vitro by inhibiting adrenal SULT2A1 activity.

  Molecular and cellular endocrinology 20110410

• Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes.

  International journal of andrology 20110401

• Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids.

  British journal of pharmacology 20110401

• The kidneys and aldosterone/mineralocorticoid receptor system in salt-sensitive hypertension.

  Current hypertension reports 20110401

• Abiraterone acetate, a novel adrenal inhibitor in metastatic castration-resistant prostate cancer.

  Current oncology reports 20110401

• Is connexin36 critical for GABAergic hypersynchronization in the hippocampus?

  The Journal of physiology 20110401

• Effects of maneb on testosterone release in male rats.

  Drug and chemical toxicology 20110401

• Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.

  PLoS genetics 20110401

• Signal transduction of pregnenolone sulfate in insulinoma cells: activation of Egr-1 expression involving TRPM3, voltage-gated calcium channels, ERK, and ternary complex factors.

  The Journal of biological chemistry 20110325

• The antidepressant-like effect of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane involves a regulation of β-type estrogen receptors.

  Psychopharmacology 20110301

• Partial defect in the cholesterol side-chain cleavage enzyme P450scc (CYP11A1) resembling nonclassic congenital lipoid adrenal hyperplasia.

  The Journal of clinical endocrinology and metabolism 20110301

• Regioselective anion attachment leading to regiospecific decompositions of bifunctional steroids in negative ion electrospray tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20110227

• Pregnenolone sulfate increases glutamate release at neonatal climbing fiber-to-Purkinje cell synapses.

  Neuroscience 20110223

• Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.

  The Journal of biological chemistry 20110218

• Uptake and elimination, and effect of estrogen-like contaminants in estuarine copepods: an experimental study.

  Environmental science and pollution research international 20110201

• Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20110201

• Expression of cytochrome P450 side-chain cleavage enzyme mRNA and production of pregnenolone in the brain of the red-bellied newt Cynops pyrrhogaster.

  General and comparative endocrinology 20110201

• The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.

  Endocrine reviews 20110201

• Temporal effect of adrenocorticotrophic hormone on adrenal glucocorticoid steroidogenesis: involvement of the transducer of regulated cyclic AMP-response element-binding protein activity.

  Journal of neuroendocrinology 20110201

• Localization and functional activity of cytochrome P450 side chain cleavage enzyme (CYP11A1) in the adult rat kidney.

  Molecular and cellular endocrinology 20110130

• Interaction between early postnatal neurosteroid manipulations and adult infusion of neurosteroids into CA1 hippocampal region on the open field behaviour.

  Behavioural brain research 20110120

• Steroid synthesis by primary human keratinocytes; implications for skin disease.

  Biochemical and biophysical research communications 20110107

• Substitution of lysine with glutamic acid at position 193 in bovine CYP11A1 significantly affects protein oligomerization and solubility but not enzymatic activity.

  Biochimica et biophysica acta 20110101

• Corticosterone evaluation in Wistar rats infected with the Y strain of Trypanosoma cruzi during the chronic phase.

  Experimental parasitology 20110101

• At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17.

  Biochimica et biophysica acta 20110101

• Microbial transformation of 3β-acetoxypregna-5,16-diene-20-one by Penicillium citrinum.

  Steroids 20110101

• Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain.

  Investigative ophthalmology & visual science 20110101

• Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathway.

  Toxicological sciences : an official journal of the Society of Toxicology 20110101

• Pregnenolone sulfate enhances survival of adult-generated hippocampal granule cells via sustained presynaptic potentiation.

  Neuropharmacology 20110101

• Preclinical pharmacokinetics, dose proportionality, gender difference and protein binding study of 16-dehydropregnenolone, an antihyperlipidemic agent, in rats.

  The Journal of pharmacy and pharmacology 20110101

• P450 side-chain cleavage deficiency--a rare cause of congenital adrenal hyperplasia.

  Endocrine development 20110101

• Pregnenolone biosynthesis in the rat salivary gland and its inhibitory effect on secretion.

  Journal of pharmacological sciences 20110101

• The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.

  BMC biochemistry 20110101

• A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile.

  PloS one 20110101

• Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology.

  Journal of ovarian research 20110101

• Correction of steroidopenia as a new method of hypercholesterolemia treatment.

  Neuro endocrinology letters 20110101

• Expression of functional melatonin MT(1) receptors in equine luteal cells: in vitro effects of melatonin on progesterone secretion.

  Reproduction, fertility, and development 20110101

• Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation.

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• New investigations around CYP11A1 and its possible involvement in an androstenone QTL characterised in Large White pigs.

  Genetics, selection, evolution : GSE 20110101

• Progression of metastatic castrate-resistant prostate cancer: impact of therapeutic intervention in the post-docetaxel space.

  Journal of hematology & oncology 20110101

• Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein.

  International journal of Alzheimer's disease 20110101

• Long-term monitoring of fecal steroid hormones in female snow leopards (Panthera uncia) during pregnancy or pseudopregnancy.

  PloS one 20110101

• Progesterone prevents development of neuropathic pain in a rat model: Timing and duration of treatment are critical.

  Journal of pain research 20110101

• Organizing effects of sex steroids on brain aromatase activity in quail.

  PloS one 20110101

• Mamld1 knockdown reduces testosterone production and Cyp17a1 expression in mouse Leydig tumor cells.

  PloS one 20110101

• Mechanism of estradiol-induced block of voltage-gated K+ currents in rat medial preoptic neurons.

  PloS one 20110101

• The role of female hormones on lung function in chronic lung diseases.

  BMC women's health 20110101

• Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia.

  PloS one 20110101

• Gender difference and sex hormone production in rodent renal ischemia reperfusion injury and repair.

  Journal of inflammation (London, England) 20110101

• Molecular characterization of novel sulfotransferases from the tick, Ixodes scapularis.

  BMC biochemistry 20110101

• The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA-10 Mouse Leydig Tumor Cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Variability in estrogen-metabolizing genes and their association with genomic instability in untreated breast cancer patients and healthy women.

  Journal of biomedicine & biotechnology 20110101

• Fractalkine is expressed in the human ovary and increases progesterone biosynthesis in human luteinised granulosa cells.

  Reproductive biology and endocrinology : RB&E 20110101

• 17-α-Hydroxylase deficiency: An unusual case with primary amenorrhea and hypertension.

  Indian journal of endocrinology and metabolism 20110101

• Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide.

  Biology of sex differences 20110101

• Different effects of hyperlipidic diets in human lactation and adulthood: growth versus the development of obesity.

  Reproductive biology and endocrinology : RB&E 20110101

• Endogenous synthesis of corticosteroids in the hippocampus.

  PloS one 20110101

• Hormone-dependent expression of a steroidogenic acute regulatory protein natural antisense transcript in MA-10 mouse tumor Leydig cells.

  PloS one 20110101

• Fluid Retention over the Menstrual Cycle: 1-Year Data from the Prospective Ovulation Cohort.

  Obstetrics and gynecology international 20110101

• Evolution of retinoid and steroid signaling: vertebrate diversification from an amphioxus perspective.

  Genome biology and evolution 20110101

• Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells.

  Lipids in health and disease 20110101

• Polymorphisms in steroidogenesis genes, sex steroid levels, and high myopia in the Taiwanese population.

  Molecular vision 20110101

• CYP17A1 intron mutation causing cryptic splicing in 17α-hydroxylase deficiency.

  PloS one 20110101

• Decidual cell polyploidization necessitates mitochondrial activity.

  PloS one 20110101

• [Screening of potential substrates or inhibitors of cytochrome P450 17A1 (CYP17A1) by electrochemical methods].

  Biomeditsinskaia khimiia 20110101

• Modulation of synaptic plasticity by stress hormone associates with plastic alteration of synaptic NMDA receptor in the adult hippocampus.

  PloS one 20110101

• Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis.

  PloS one 20110101

• Neurosteroid Binding Sites on the GABA(A) Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence.

  Advances in pharmacological sciences 20110101

• New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer.

  Prostate cancer 20110101

• Nuclear progesterone receptors are up-regulated by estrogens in neurons and radial glial progenitors in the brain of zebrafish.

  PloS one 20110101

• The brain of teleost fish, a source, and a target of sexual steroids.

  Frontiers in neuroscience 20110101

• Role of aldo-keto reductase enzymes in mediating the timing of parturition.

  Frontiers in pharmacology 20110101

• Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor.

  Frontiers in neuroscience 20110101

• MRP8/ABCC11 expression is regulated by dexamethasone in breast cancer cells and is associated to progesterone receptor status in breast tumors.

  International journal of breast cancer 20110101

• The Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease.

  ISRN neurology 20110101

• Mode of action and functional significance of 7α-hydroxypregnenolone stimulating locomotor activity.

  Frontiers in endocrinology 20110101

• Neurosteroid biosynthesis and function in the brain of domestic birds.

  Frontiers in endocrinology 20110101

• Membrane-initiated estradiol signaling regulating sexual receptivity.

  Frontiers in endocrinology 20110101

• Neuroprotective actions of neurosteroids.

  Frontiers in endocrinology 20110101

• A role for the androgen metabolite, 5alpha androstane 3beta, 17beta diol (3β-diol) in the regulation of the hypothalamo-pituitary-adrenal axis.

  Frontiers in endocrinology 20110101

• Steroidogenic acute regulatory protein expression in the central nervous system.

  Frontiers in endocrinology 20110101

• Neurosteroid biosynthesis in the brain of amphibians.

  Frontiers in endocrinology 20110101

• Transcriptome-wide identification of preferentially expressed genes in the hypothalamus and pituitary gland.

  Frontiers in endocrinology 20110101

• Sunitinib Inhibits Cell Proliferation and Alters Steroidogenesis by Down-Regulation of HSD3B2 in Adrenocortical Carcinoma Cells.

  Frontiers in endocrinology 20110101

• Estradiol synthesis and action at the synapse: evidence for 'synaptocrine' signaling.

  Frontiers in endocrinology 20110101

• Male/Female differences in neuroprotection and neuromodulation of brain dopamine.

  Frontiers in endocrinology 20110101

• Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy.

  Frontiers in endocrinology 20110101

• Measurement of steroid concentrations in brain tissue: methodological considerations.

  Frontiers in endocrinology 20110101

• Wired on steroids: sexual differentiation of the brain and its role in the expression of sexual partner preferences.

  Frontiers in endocrinology 20110101

• Neurosteroids and GABA-A Receptor Function.

  Frontiers in endocrinology 20110101

• Neurosteroids as neuromodulators in the treatment of anxiety disorders.

  Frontiers in endocrinology 20110101

• Biosynthesis, mode of action, and functional significance of neurosteroids in the purkinje cell.

  Frontiers in endocrinology 20110101

• Oxidative Stress-Mediated Brain Dehydroepiandrosterone (DHEA) Formation in Alzheimer's Disease Diagnosis.

  Frontiers in endocrinology 20110101

• Comparative endocrinology of aging and longevity regulation.

  Frontiers in endocrinology 20110101

• The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge.

  Frontiers in endocrinology 20110101

• Role of neuroactive steroids in the peripheral nervous system.

  Frontiers in endocrinology 20110101

• Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease.

  Frontiers in endocrinology 20110101

• Hippocampal synthesis of sex steroids and corticosteroids: essential for modulation of synaptic plasticity.

  Frontiers in endocrinology 20110101

• Sex-specific effects of early neonatal progesterone treatment on dopamine and serotonin metabolism in rat striatum and frontal cortex.

  Life sciences 20101218

• Simultaneous determination of pregnenolone and 17α-hydroxypregnenolone by semi-micro high-performance liquid chromatography with an immobilized cholesterol oxidase as a pre-column reactor: application to bovine adrenal fasciculata cells.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101215

• D-ring substituted 1,2,3-triazolyl 20-keto pregnenanes as potential anticancer agents: Synthesis and biological evaluation.

  Steroids 20101201

• Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents.

  Steroids 20101201

• Effects and mechanisms of nonylphenol on corticosterone release in rat zona fasciculata-reticularis cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20101201

• Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20101201

• Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring p rats.

  Alcoholism, clinical and experimental research 20101201

• Pregnenolone sulfate enhances spontaneous glutamate release by inducing presynaptic Ca2+-induced Ca2+ release.

  Neuroscience 20101124

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Allosteric modulation of the NMDA receptor by neurosteroids in rat brain and the impact of long term morphine administration.

  Biochemical and biophysical research communications 20101029

• Neuroticism-related personality traits are related to symptom severity in patients with premenstrual dysphoric disorder and to the serotonin transporter gene-linked polymorphism 5-HTTPLPR.

  Archives of women's mental health 20101001

• Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy.

  The Journal of steroid biochemistry and molecular biology 20101001

• Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial.

  The Journal of clinical psychiatry 20101001

• Chronic ethanol exposure produces tolerance to elevations in neuroactive steroids: mechanisms and reversal by exogenous ACTH.

  Journal of neurochemistry 20101001

• Neurosteroid transport by the organic solute transporter OSTα-OSTβ.

  Journal of neurochemistry 20101001

• Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss).

  Aquatic toxicology (Amsterdam, Netherlands) 20101001

• Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO).

  Bioorganic & medicinal chemistry letters 20101001

• Human 20α-hydroxysteroid dehydrogenase (AKR1C1)-dependent biotransformation with recombinant fission yeast Schizosaccharomyces pombe.

  Journal of biotechnology 20101001

• Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001.

  Pain medicine (Malden, Mass.) 20101001

• Pharmacogenomics of human ABC transporter ABCC11 (MRP8): potential risk of breast cancer and chemotherapy failure.

  Anti-cancer agents in medicinal chemistry 20101001

• [17(20)E]- and [17(20)Z]-pregna-5,17(20)-dien-21-oylamides. Facile synthesis and primary evaluation for cancer cells proliferation.

  Bioorganic & medicinal chemistry letters 20100915

• Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100908

• Progress in dorsal root ganglion neurosteroidogenic activity: basic evidence and pathophysiological correlation.

  Progress in neurobiology 20100901

• Endocrine disrupting chemicals bind to a novel receptor, microtubule-associated protein 2, and positively and negatively regulate dendritic outgrowth in hippocampal neurons.

  Journal of neurochemistry 20100901

• Liverbeads: a practical and relevant in vitro model for gene induction investigations.

  Drug metabolism and disposition: the biological fate of chemicals 20100901

• Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration.

  European journal of pharmacology 20100901

• Mouse cytosolic sulfotransferase SULT2B1b interacts with cytoskeletal proteins via a proline/serine-rich C-terminus.

  The FEBS journal 20100901

• Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels.

  British journal of pharmacology 20100901

• Synthesis and cytotoxicity studies of steroid-functionalized titanocenes as potential anticancer drugs: sex steroids as potential vectors for titanocenes.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100801

• Regulation of mRNAs encoding the steroidogenic acute regulatory protein and cholesterol side-chain cleavage enzyme in the elasmobranch interrenal gland.

  General and comparative endocrinology 20100801

• Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS).

  The Journal of steroid biochemistry and molecular biology 20100801

• Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.

  Biochimica et biophysica acta 20100801

• Sex-dimorphic changes in neuroactive steroid levels after chronic experimental autoimmune encephalomyelitis.

  Journal of neurochemistry 20100801

• Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channels.

  Journal of hypertension 20100801

• Pregnenolone for cognition and mood in dual diagnosis patients.

  Psychiatry research 20100730

• Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy.

  Journal of molecular biology 20100730

• Pregnenolone sulfate and cortisol induce secretion of acyl-CoA-binding protein and its conversion into endozepines from astrocytes.

  The Journal of biological chemistry 20100709

• The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas.

  Clinical endocrinology 20100701

• The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver.

  Drug metabolism and disposition: the biological fate of chemicals 20100701

• Clinical, genetic, and functional characterization of four patients carrying partial loss-of-function mutations in the steroidogenic acute regulatory protein (StAR).

  The Journal of clinical endocrinology and metabolism 20100701

• [Pregnenolone, pregnenolone sulfate].

  Nihon rinsho. Japanese journal of clinical medicine 20100701

• Modulation of steroidogenesis and estrogen signalling in the estuarine killifish (Fundulus heteroclitus) exposed to ethinylestradiol.

  Aquatic toxicology (Amsterdam, Netherlands) 20100610

• The PXR is a drug target for chronic inflammatory liver disease.

  The Journal of steroid biochemistry and molecular biology 20100531

• Screening of ovarian steroidogenic pathway in Ciona intestinalis and its modulation after tributyltin exposure.

  Toxicology and applied pharmacology 20100515

• Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.

  Circulation research 20100514

• MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein.

  Journal of lipid research 20100501

• Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone.

  Experimental dermatology 20100501

• Abiraterone acetate: a promising drug for the treatment of castration-resistant prostate cancer.

  Future oncology (London, England) 20100501

• Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity.

  Neuroscience letters 20100412

• Modulatory metaplasticity induced by pregnenolone sulfate in the rat hippocampus: a leftward shift in LTP/LTD-frequency curve.

  Hippocampus 20100401

• A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase.

  The Journal of steroid biochemistry and molecular biology 20100401

• Neurosteroids and epilepsy.

  Current opinion in neurology 20100401

• Endogenous steroids measured by high-specificity liquid chromatography-tandem mass spectrometry and prevalent cardiovascular disease in 70-year-old men and women.

  The Journal of clinical endocrinology and metabolism 20100401

• A new steroidal 5,7-diene derivative, 3beta-hydroxyandrosta-5,7-diene-17beta-carboxylic acid, shows potent anti-proliferative activity.

  Steroids 20100301

• Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans.

  Alcoholism, clinical and experimental research 20100301

• Day-to-day differences in cortisol levels and molar cortisol-to-DHEA ratios among working individuals.

  Yonsei medical journal 20100301

• Steroid assays in paediatric endocrinology.

  Journal of clinical research in pediatric endocrinology 20100301

• Hypocortisolism in the South African angora goat: the role of 3betaHSD.

  Molecular and cellular endocrinology 20100205

• Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells.

  Toxicology and applied pharmacology 20100201

• Fusaric acid as a novel proton-affinitive derivatizing reagent for highly sensitive quantification of hydroxysteroids by LC-ESI-MS/MS.

  Journal of the American Society for Mass Spectrometry 20100201

• Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis.

  Journal of neurochemistry 20100201

• Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer.

  Cancer research 20100201

• StarD4-mediated translocation of 7-hydroperoxycholesterol to isolated mitochondria: deleterious effects and implications for steroidogenesis under oxidative stress conditions.

  Biochemical and biophysical research communications 20100129

• Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons.

  Glia 20100115

• Simple methodology coupling microwave-assisted extraction to SPE/GC/MS for the analysis of natural steroids in biological tissues: application to the monitoring of endogenous steroids in marine mussels Mytilus sp.

  Analytica chimica acta 20100104

• Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats.

  Hormones and behavior 20100101

• Is maternal progesterone actually independent of the fetal steroids?

  Physiological research 20100101

• Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20100101

• Possible contribution of 2-aminoethoxydiphenyl-borate-sensitive Ca2+ mobilization to adrenocorticotropin-induced glucocorticoid synthesis in rat adrenocortical cells.

  Endocrine journal 20100101

• Investigation of urinary steroid metabolites in calf urine after oral and intramuscular administration of DHEA.

  Analytical and bioanalytical chemistry 20100101

• Steroidogenesis in the brain of Sepia officinalis and Octopus vulgaris.

  Frontiers in bioscience (Elite edition) 20100101

• Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells.

  Acta pharmacologica Sinica 20100101

• Comparative transcriptomic analysis of follicle-enclosed oocyte maturational and developmental competence acquisition in two non-mammalian vertebrates.

  BMC genomics 20100101

• Pregnenolone, dehydroepiandrosterone, and schizophrenia: alterations and clinical trials.

  CNS neuroscience & therapeutics 20100101

• Transcript profiling of candidate genes in testis of pigs exhibiting large differences in androstenone levels.

  BMC genetics 20100101

• Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies.

  Reproductive biology and endocrinology : RB&E 20100101

• Sleep, Hormones, and Circadian Rhythms throughout the Menstrual Cycle in Healthy Women and Women with Premenstrual Dysphoric Disorder.

  International journal of endocrinology 20100101

• Effects of luteectomy in early pregnancy on the maintenance of gestation and plasma progesterone concentrations in the viviparous temperate lizard Barisia imbricata imbricata.

  Reproductive biology and endocrinology : RB&E 20100101

• Genomic and neural analysis of the estradiol-synthetic pathway in the zebra finch.

  BMC neuroscience 20100101

• Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

  PloS one 20100101

• A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly.

  PloS one 20100101

• Progesterone - new therapy in mild carpal tunnel syndrome? Study design of a randomized clinical trial for local therapy.

  Journal of brachial plexus and peripheral nerve injury 20100101

• Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory.

  Pharmacological reports : PR 20100101

• Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.

  Nutrition & metabolism 20100101

• TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan.

  BMC musculoskeletal disorders 20100101

• [Characteristics of steroid metabolism in transgenic Nicotiana tabacum plants bearing the CYP11A1 cDNA of cytochrome P450(SCC) from the bovine adrenal cortex].

  Bioorganicheskaia khimiia 20100101

• Impact of methoxyacetic acid on mouse Leydig cell gene expression.

  Reproductive biology and endocrinology : RB&E 20100101

• Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk.

  BMC systems biology 20100101

• Sulphates of 3beta-hydroxy-5-ene steroids in women with epilepsy.

  Prague medical report 20100101

• The LH/hCG Axis in Endometrial Cancer: A New Target in the Treatment of Recurrent or Metastatic Disease.

  Obstetrics and gynecology international 20100101

• [Neurosteroids and addictive pathology].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes.

  Stem cell research & therapy 20100101

• Endocrine disruptors and Leydig cell function.

  Journal of biomedicine & biotechnology 20100101

• Estradiol, progesterone, testosterone profiles in human follicular fluid and cultured granulosa cells from luteinized pre-ovulatory follicles.

  Reproductive biology and endocrinology : RB&E 20100101

• Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility.

  Breast cancer research : BCR 20100101

• HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression.

  Journal of inflammation (London, England) 20100101

• [Age-related changes in blood concentration of hypothalamic-pituitary-adrenal axis hormones, their central and peripheral regulators in healthy men].

  Fiziologiia cheloveka 20100101

• Treatment of Cushing disease: overview and recent findings.

  Therapeutics and clinical risk management 20100101

• Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish.

  BMC genomics 20100101

• Neurosteroids: endogenous role in the human brain and therapeutic potentials.

  Progress in brain research 20100101

• Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms.

  Neuropsychiatric disease and treatment 20100101

• Roles of hCG in Advancing Follicular Growth to Ovulation after Concurrent Injections of PGF(2α) and GnRH in Postpubertal Holstein Heifers Bearing a CL.

  Veterinary medicine international 20100101

• Hippocampal testosterone relates to reference memory performance and synaptic plasticity in male rats.

  Frontiers in behavioral neuroscience 20100101

• Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis.

  BMC genomics 20100101

• Effects of neurosteroids on the human corticotropin-releasing hormone gene.

  Pharmacological reports : PR 20100101

• Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor α.

  PPAR research 20100101

• Deciphering the nuclear bile acid receptor FXR paradigm.

  Nuclear receptor signaling 20100101

• 7α-hydroxypregnenolone, a new key regulator of locomotor activity of vertebrates: identification, mode of action, and functional significance.

  Frontiers in endocrinology 20100101

• Simultaneous determination of 15 steroids in rat blood via gas chromatography-mass spectrometry to evaluate the impact of emasculation on adrenal.

  Talanta 20091215

• Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.

  Journal of medicinal chemistry 20091210

• Plasticity of the zona reticularis in the adult marmoset adrenal cortex: voyages of discovery in the New World.

  The Journal of endocrinology 20091201

• Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the key.

  Journal of lipid research 20091201

• Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy.

  Neuroscience 20091201

• Retinoic acids induce neurosteroid biosynthesis in human glial GI-1 Cells via the induction of steroidogenic genes.

  Journal of biochemistry 20091201

• The effect of ovarian steroids on oxytocin-stimulated secretion and synthesis of prostaglandins in bovine myometrial cells.

  Prostaglandins & other lipid mediators 20091201

• The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals.

  Endocrinology 20091201

• Synthesis of 3beta, 7alpha, 11alpha-trihydroxy-pregn-21-benzylidene-5-en-20-one derivatives and their cytotoxic activities.

  Bioorganic & medicinal chemistry letters 20091201

• A novel hydroxysteroid-sulfating cytosolic sulfotransferase, SULT3 ST3, from zebrafish: identification, characterization, and ontogenic study.

  Drug metabolism letters 20091201

• [Activity induced by androsterone and hemisuccinate of androsterone on perfusion pressure and vascular resistance].

  Biomedica : revista del Instituto Nacional de Salud 20091201

• Synthesis of pregnane derivatives, their cytotoxicity on LNCap and PC-3 cells, and screening on 5alpha-reductase inhibitory activity.

  Molecules (Basel, Switzerland) 20091117

• Regulation of prostaglandin synthesis in ovaries of sexually-mature zebrafish (Danio rerio).

  Molecular reproduction and development 20091101

• Effects of hypoxia on testosterone release in rat Leydig cells.

  American journal of physiology. Endocrinology and metabolism 20091101

• Estrus cyclicity of spinogenesis: underlying mechanisms.

  Journal of neural transmission (Vienna, Austria : 1996) 20091101

• Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice.

  Journal of lipid research 20091001

• Studies on Baeyer-Villiger oxidation of steroids: DHEA and pregnenolone D-lactonization pathways in Penicillium camemberti AM83.

  Steroids 20091001

• Altered levels of synapsin I, dopamine transporter, dynorphin A, and neuropeptide Y in the nucleus accumbens and striatum at post-puberty in rats treated neonatally with pregnenolone or DHEA.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20091001

• Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance.

  Progress in neurobiology 20091001

• Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats.

  Journal of cellular biochemistry 20091001

• Effects of heme oxygenase isozymes on Leydig cells steroidogenesis.

  The Journal of endocrinology 20091001

• Discovery of neurosteroid glucuronides in mouse brain.

  Analytica chimica acta 20090928

• Transcriptional activation of zebrafish cyp11a1 promoter is dependent on the nuclear receptor Ff1b.

  Journal of molecular endocrinology 20090901

• Retinoic acid stimulates 17beta-estradiol and testosterone synthesis in rat hippocampal slice cultures.

  Endocrinology 20090901

• Atrazine oral exposure of peripubertal male rats downregulates steroidogenesis gene expression in Leydig cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20090901

• [Construction and characteristics of transgenic tobacco Nicotiana tabacum L. plants expressing CYP11A1 cDNA encoding cytochrome P450scc].

  Genetika 20090901

• Diagnosis of diseases of steroid hormone production, metabolism and action.

  Journal of clinical research in pediatric endocrinology 20090901

• Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention.

  Biological psychiatry 20090815

• Metabolomics approach to anabolic steroid urine profiling of bovines treated with prohormones.

  Analytical chemistry 20090815

• Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.

  Molecular endocrinology (Baltimore, Md.) 20090801

• Biotransformations of steroid compounds by Chaetomium sp. KCH 6651.

  Steroids 20090801

• Arsenic inhibits in vitro spermatogenesis and induces germ cell apoptosis in Japanese eel (Anguilla japonica).

  Reproduction (Cambridge, England) 20090801

• Anabolic utilization of steroid hormones in Helicobacter pylori.

  FEMS microbiology letters 20090801

• Gradient HPLC separation of dehydroepiandrosterone (DHEA) from its metabolites and biological congeners: role of tetrahydrofuran in the chromatographic mechanism.

  Analytical and bioanalytical chemistry 20090801

• Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.

  PLoS genetics 20090801

• Chronic dietary exposure to a low-dose mixture of genistein and vinclozolin modifies the reproductive axis, testis transcriptome, and fertility.

  Environmental health perspectives 20090801

• Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.

  Toxicology letters 20090710

• To determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines.

  European journal of medicinal chemistry 20090701

• Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.

  European journal of medicinal chemistry 20090701

• Steroid hormones affect binding of the sigma ligand 11C-SA4503 in tumour cells and tumour-bearing rats.

  European journal of nuclear medicine and molecular imaging 20090701

• Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090701

• Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor.

  Drug metabolism and disposition: the biological fate of chemicals 20090701

• Expression and modulation of translocator protein and its partners by hypoxia reoxygenation or ischemia and reperfusion in porcine renal models.

  American journal of physiology. Renal physiology 20090701

• 17alpha-hydroxylase/17,20-lyase (p450(17alpha)) inhibitors in the treatment of prostate cancer: a review.

  Anti-cancer agents in medicinal chemistry 20090701

• Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes.

  Environmental health perspectives 20090701

• N-tert-Butyl-3-hydr-oxy-5-androstene-17-carboxamide monohydrate.

  Acta crystallographica. Section E, Structure reports online 20090701

• The 3beta-hydroxysteroid dehydrogenase inhibitor trilostane shows antidepressant properties in mice.

  Psychoneuroendocrinology 20090601

• Differentiation-dependent progesterone synthesis and metabolism in NT2-N human neurons.

  Experimental neurology 20090601

• Pregnenolone sulfate modulation of N-methyl-D-aspartate receptors is phosphorylation dependent.

  Neuroscience 20090519

• Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation.

  Journal of lipid research 20090501

• Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice.

  Journal of pharmacological sciences 20090501

• Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1).

  Drug metabolism and disposition: the biological fate of chemicals 20090401

• Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan.

  Reproductive toxicology (Elmsford, N.Y.) 20090401

• Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain.

  American journal of hypertension 20090401

• Metabolism of neuroactive steroids in day-old chick brain.

  Journal of neurochemistry 20090401

• Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor.

  Environmental health perspectives 20090401

• Identification, biosynthesis, and function of 7alpha-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity, in nonmammalian vertebrates.

  Annals of the New York Academy of Sciences 20090401

• Immunohistochemical localization of hydroxysteroid sulfotransferase and sulfatase in the brain of Rana esculenta tadpoles.

  Annals of the New York Academy of Sciences 20090401

• Dehydroepiandrosterone and neurotrophins favor axonal growth in a sensory neuron-keratinocyte coculture model.

  Neuroscience 20090317

• CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer.

  British journal of cancer 20090310

• Androgen synthesis in adrenarche.

  Reviews in endocrine & metabolic disorders 20090301

• A novel homozygous mutation in CYP11A1 gene is associated with late-onset adrenal insufficiency and hypospadias in a 46,XY patient.

  The Journal of clinical endocrinology and metabolism 20090301

• Steroid profiles in ovarian follicular fluid from regularly menstruating women and women after ovarian stimulation.

  Clinical chemistry 20090301

• The effect of the neuroactive steroid 5beta-pregnane-3beta, 20(R)-diol on the time course of GABA evoked currents is different to that of pregnenolone sulphate.

  European journal of pharmacology 20090301

• Calmodulin effects on steroids-regulated plasma membrane calcium pump activity.

  Cell biochemistry and function 20090301

• Androgen suppresses corticotropin-induced increase in plasma cortisol level but enhances the increase in plasma aldosterone level in goats.

  The Journal of veterinary medical science 20090301

• Adverse effects of a clinically relevant dose of hydroxyurea used for the treatment of sickle cell disease on male fertility endpoints.

  International journal of environmental research and public health 20090301

• Transcription of steroidogenic acute regulatory protein in the rodent ovary and placenta: alternative modes of cyclic adenosine 3', 5'-monophosphate dependent and independent regulation.

  Endocrinology 20090201

• Close examination of steroidogenesis disorders in a DOC- and progesterone-producing adrenocortical carcinoma.

  Endocrine 20090201

• Transformation of 5-ene steroids by the fungus Aspergillus tamarii KITA: mixed molecular fate in lactonization and hydroxylation pathways with identification of a putative 3beta-hydroxy-steroid dehydrogenase/Delta5-Delta4 isomerase pathway.

  Biochimica et biophysica acta 20090201

• Effects of two new steroids and cyproterone on some biomarkers of oxidative stress and serotonergic system on rat prostate and brain.

  Andrologia 20090201

• Pregnenolone protects the PC-12 cell line against amyloid beta peptide toxicity but its sulfate ester does not.

  Chemico-biological interactions 20090115

• Possible GABAergic mechanism in the protective effect of allopregnenolone against immobilization stress.

  European journal of pharmacology 20090114

• Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: an endocrine-disruption theory of schizophrenia.

  Schizophrenia bulletin 20090101

• Involvement of nitric oxide synthase in the mechanism of histamine-induced inhibition of Leydig cell steroidogenesis via histamine receptor subtypes in Sprague-Dawley rats.

  Biology of reproduction 20090101

• Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090101

• The role of porcine cytochrome b5A and cytochrome b5B in the regulation of cytochrome P45017A1 activities.

  The Journal of steroid biochemistry and molecular biology 20090101

• Glycine receptor in rat hippocampal and spinal cord neurons as a molecular target for rapid actions of 17-beta-estradiol.

  Molecular pain 20090101

• Gene expression profiling of alveolar soft-part sarcoma (ASPS).

  BMC cancer 20090101

• Model-based therapeutic correction of hypothalamic-pituitary-adrenal axis dysfunction.

  PLoS computational biology 20090101

• Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum.

  Steroids 20090101

• Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin.

  PloS one 20090101

• The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

  Nuclear receptor signaling 20090101

• Minimizing the effects of multicollinearity in the polynomial regression of age relationships and sex differences in serum levels of pregnenolone sulfate in healthy subjects.

  Clinical chemistry and laboratory medicine 20090101

• Development of ELISA for measurement of progesterone employing 17-alpha-OH-P-HRP as enzyme label.

  Journal of immunoassay & immunochemistry 20090101

• Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling.

  BMC genomics 20090101

• Endocrine activity of extraembryonic membranes extends beyond placental amniotes.

  PloS one 20090101

• Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics.

  Comparative hepatology 20090101

• A novel approach to investigate the subcellular distribution of nuclear receptors in vivo.

  Nuclear receptor signaling 20090101

• Gestagens and glucocorticoids in chicken eggs.

  General and comparative endocrinology 20090101

• Molecular characterization of lung dysplasia induced by c-Raf-1.

  PloS one 20090101

• Nongenomic mechanisms of physiological estrogen-mediated dopamine efflux.

  BMC neuroscience 20090101

• Activation of PPARγ by Rosiglitazone does not negatively impact male sex steroid hormones in diabetic rats.

  PPAR research 20090101

• 20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes.

  PloS one 20090101

• Translocator protein ligands as promising therapeutic tools for anxiety disorders.

  Current medicinal chemistry 20090101

• Metabolites of an Epac-selective cAMP analog induce cortisol synthesis by adrenocortical cells through a cAMP-independent pathway.

  PloS one 20090101

• Association between SNPs within candidate genes and compounds related to boar taint and reproduction.

  BMC genetics 20090101

• Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo.

  Reproductive biology and endocrinology : RB&E 20090101

• Pregnenolone sulfate potentiates the inwardly rectifying K channel Kir2.3.

  PloS one 20090101

• Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study.

  Journal of ovarian research 20090101

• Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs.

  PPAR research 20090101

• The phytoestrogen quercetin impairs steroidogenesis and angiogenesis in swine granulosa cells in vitro.

  Journal of biomedicine & biotechnology 20090101

• Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gain.

  Reproductive biology and endocrinology : RB&E 20090101

• Monitoring sterol uptake, acetylation, and export in yeast.

  Methods in molecular biology (Clifton, N.J.) 20090101

• History, mystery and chemistry of eroticism: Emphasis on sexual health and dysfunction.

  Indian journal of psychiatry 20090101

• Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging.

  Aging 20090101

• Direct rosiglitazone action on steroidogenesis and proinflammatory factor production in human granulosa-lutein cells.

  Reproductive biology and endocrinology : RB&E 20090101

• Toxicity of xanthene food dyes by inhibition of human drug-metabolizing enzymes in a noncompetitive manner.

  Journal of environmental and public health 20090101

• [Age-dependent changes in the concentration of active sex steroids, their precursors, metabolites, and regulating agents in male blood].

  Ontogenez 20090101

• Characterization of a stable steroidogenic caprine luteal cell line transformed by a temperature-sensitive simian virus 40.

  The Chinese journal of physiology 20081231

• Baeyer-Villiger oxidation of DHEA, pregnenolone, and androstenedione by Penicillium lilacinum AM111.

  Steroids 20081222

• Effect of warm-rearing and heat acclimation on pituitary-gonadal axis in male rats.

  International journal of andrology 20081201

• Steroidogenic acute regulatory (StAR) protein and cholesterol side-chain cleavage (P450scc)-regulated steroidogenesis as an organ-specific molecular and cellular target for endocrine disrupting chemicals in fish.

  Cell biology and toxicology 20081201

• Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo.

  The Journal of pharmacology and experimental therapeutics 20081201

• Studies of membrane topology of mitochondrial cholesterol hydroxylases CYPs 27A1 and 11A1.

  Lipids 20081201

• A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.

  Drug metabolism and disposition: the biological fate of chemicals 20081201

• Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells.

  Nature cell biology 20081201

• Umbelliferone and esculetin: inhibitors or substrates for polyphenol oxidases?

  Biological & pharmaceutical bulletin 20081201

• A TRP channel-steroid marriage.

  Nature cell biology 20081201

• [Studies on chemical constituents in roots and rhizomes of Notopterygium incisum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081201

• Zearalenone and reproductive function in farm animals.

  International journal of molecular sciences 20081201

• Pharmacology and therapeutic potential of sigma(1) receptor ligands.

  Current neuropharmacology 20081201

• Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis.

  Endocrinology 20081101

• A post-training intrahippocampal anxiogenic dose of the neurosteroid pregnenolone sulfate impairs passive avoidance retention.

  Experimental brain research 20081101

• Experimental benefits of sex hormones on vascular function and the outcome of hormone therapy in cardiovascular disease.

  Current cardiology reviews 20081101

• Automated solid-phase extraction for concentration and clean-up of female steroid hormones prior to liquid chromatography-electrospray ionization-tandem mass spectrometry: an approach to lipidomics.

  Journal of chromatography. A 20081017

• Routine method for the simultaneous quantification of 17alpha-hydroxyprogesterone, testosterone, dehydroepiandrosterone, androstenedione, cortisol, and pregnenolone in human serum of neonates using gas chromatography-mass spectrometry.

  Journal of chromatography. A 20081010

• N-terminus of MAP2C as a neurosteroid-binding site.

  Neuroreport 20081008

• Role of transforming growth factor-beta1 in gene expression and activity of estradiol and progesterone-generating enzymes in FSH-stimulated bovine granulosa cells.

  Reproduction (Cambridge, England) 20081001

• Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum.

  Journal of neurochemistry 20081001

• Neurosteroids as modulators of neurogenesis and neuronal survival.

  Trends in endocrinology and metabolism: TEM 20081001

• Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.

  Journal of medicinal chemistry 20080925

• A comparison of the pharmacological properties of recombinant human and rat alpha(1)beta(2)gamma(2L) GABA(A) receptors in Xenopus oocytes.

  Clinical and experimental pharmacology & physiology 20080901

• Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.

  Molecular pharmacology 20080901

• ATR/Raman and fractal characterization of HPBCD/progesterone complex solid particles.

  Pharmaceutical research 20080901

• The key steroidogenic enzyme 3beta-hydroxysteroid dehydrogenase in Taenia solium and Taenia crassiceps (WFU).

  Parasitology research 20080901

• In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5alpha-reductase inhibitors.

  The Journal of steroid biochemistry and molecular biology 20080901

• The adaptive response of adult rat Leydig cells to repeated immobilization stress: the role of protein kinase A and steroidogenic acute regulatory protein.

  Stress (Amsterdam, Netherlands) 20080901

• Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901

• Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury.

  Neuroscience 20080826

• A further case of the recurrent 15q24 microdeletion syndrome, detected by array CGH.

  European journal of pediatrics 20080801

• Neuroactive steroid pregnenolone sulphate inhibits long-term potentiation via activation of alpha2-adrenoreceptors at excitatory synapses in rat medial prefrontal cortex.

  The international journal of neuropsychopharmacology 20080801

• Stem cell review series: role of neurogenesis in age-related memory disorders.

  Aging cell 20080801

• Involvement of sigma (sigma1) receptors in modulating the anti-depressant effect of neurosteroids (dehydroepiandrosterone or pregnenolone) in mouse tail-suspension test.

  Journal of psychopharmacology (Oxford, England) 20080801

• Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.

  The Journal of clinical endocrinology and metabolism 20080801

• Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080801

• Purification and characterization of Chromobacterium sp. DS-1 cholesterol oxidase with thermal, organic solvent, and detergent tolerance.

  Applied microbiology and biotechnology 20080801

• Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout.

  Environmental health perspectives 20080801

• Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A.

  Biochemical and biophysical research communications 20080725

• Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration.

  Neuroscience 20080717

• Effects of dehydroepiandrosterone on aldosterone release in rat zona glomerulosa cells.

  Journal of biomedical science 20080701

• Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy.

  Epilepsia 20080701

• Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species.

  Environmental health perspectives 20080701

• The Endocrinology of equine parturition.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20080701

• The influence of Sutherlandia frutescens on adrenal steroidogenic cytochrome P450 enzymes.

  Journal of ethnopharmacology 20080619

• Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.

  The international journal of neuropsychopharmacology 20080601

• Progress in understanding androgen-independent prostate cancer (AIPC): a review of potential endocrine-mediated mechanisms.

  European urology 20080601

• Regulatory role of cytochrome P450scc and pregnenolone in myelination by rat Schwann cells.

  Molecular and cellular biochemistry 20080601

• Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding.

  Biochimica et biophysica acta 20080601

• Neurosteroids 3beta, 20 (R/S)-pregnandiols decrease offset rate of the GABA-site activation at the recombinant GABA A receptor.

  European journal of pharmacology 20080531

• Molecular mechanism of reduction in pregnenolone synthesis by cigarette smoke.

  Toxicology and applied pharmacology 20080515

• Effects of neurosteroids on hydrogen peroxide- and staurosporine-induced damage of human neuroblastoma SH-SY5Y cells.

  Journal of neuroscience research 20080501

• Dose-dependent and sequence-sensitive effects of amyloid-beta peptide on neurosteroidogenesis in human neuroblastoma cells.

  Neurochemistry international 20080501

• Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes.

  Reproduction (Cambridge, England) 20080501

• DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080501

• Real-time analysis of gene regulation by glucocorticoid hormones.

  The Journal of endocrinology 20080501

• Chrysin, a natural flavonoid enhances steroidogenesis and steroidogenic acute regulatory protein gene expression in mouse Leydig cells.

  The Journal of endocrinology 20080501

• Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and phosphate carrier protein.

  The Journal of biological chemistry 20080404

• A simple chemical method for synthesizing malonyl hemiesters of 21-hydroxypregnanes, potential intermediates in cardenolide biosynthesis.

  Steroids 20080401

• Carboxyl-terminal mutations in 3beta-hydroxysteroid dehydrogenase type II cause severe salt-wasting congenital adrenal hyperplasia.

  The Journal of clinical endocrinology and metabolism 20080401

• Platinum(II) complexes with steroidal esters of L-methionine and L-histidine: synthesis, characterization and cytotoxic activity.

  Bioorganic & medicinal chemistry 20080401

• Endogenous steroid production in the spinal cord and potential involvement in neuropathic pain modulation.

  The Journal of steroid biochemistry and molecular biology 20080401

• Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder.

  Brain research reviews 20080301

• Changes in cytochrome P450 side chain cleavage expression in the rat hippocampus after kainate injury.

  Experimental brain research 20080301

• Cigarette smoke decreases mitochondrial porin expression and steroidogenesis.

  Toxicology and applied pharmacology 20080301

• Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc.

  The Journal of clinical endocrinology and metabolism 20080301

• In vitro conversion of sex steroids and expression of sex steroidogenic enzyme genes in amphioxus ovary.

  Journal of experimental zoology. Part A, Ecological genetics and physiology 20080301

• Steroid sulfatase and sulfuryl transferase activities in human brain tumors.

  The Journal of steroid biochemistry and molecular biology 20080301

• Selective regulation of neurosteroid biosynthesis in human neuroblastoma cells under hydrogen peroxide-induced oxidative stress condition.

  Neuroscience 20080206

• Modulatory effect of neurosteroids in haloperidol-induced vacuous chewing movements and related behaviors.

  Psychopharmacology 20080201

• Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance.

  The Journal of pharmacology and experimental therapeutics 20080201

• Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells.

  British journal of pharmacology 20080201

• Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice.

  Drug metabolism and disposition: the biological fate of chemicals 20080201

• Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects.

  Psychoneuroendocrinology 20080201

• Neurosteroids block the increase in intracellular calcium level induced by Alzheimer’s β-amyloid protein in long-term cultured rat hippocampal neurons.

  Neuropsychiatric disease and treatment 20080201

• Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway.

  Toxicology letters 20080104

• Regulation of SULT2B1a (pregnenolone sulfotransferase) expression in rat C6 glioma cells: relevance of AMPA receptor-mediated NO signaling.

  Neuroscience letters 20080103

• Reduced plasma dehydroepiandrosterone sulfate levels are significantly correlated with fatigue severity in patients with primary biliary cirrhosis.

  Neurochemistry international 20080101

• Evaluation of neuroactive steroid levels by liquid chromatography-tandem mass spectrometry in central and peripheral nervous system: effect of diabetes.

  Neurochemistry international 20080101

• Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080101

• SMAD3 inhibits SF-1-dependent activation of the CYP17 promoter in H295R cells.

  Molecular and cellular biochemistry 20080101

• Emergence of NMDAR-independent long-term potentiation at hippocampal CA1 synapses following early adolescent exposure to chronic intermittent ethanol: role for sigma-receptors.

  Hippocampus 20080101

• Predominant allylic hydroxylation at carbons 6 and 7 of 4 and 5-ene functionalized steroids by the thermophilic fungus Rhizomucor tauricus IMI23312.

  The Journal of steroid biochemistry and molecular biology 20080101

• Pregnenolone sulfate in the brain: a controversial neurosteroid.

  Neurochemistry international 20080101

• Role of the peroxisome proliferator-activated receptors, adenosine monophosphate-activated kinase, and adiponectin in the ovary.

  PPAR research 20080101

• Peroxisome proliferator-activated receptors as mediators of phthalate-induced effects in the male and female reproductive tract: epidemiological and experimental evidence.

  PPAR research 20080101

• The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase.

  Clinical practice and epidemiology in mental health : CP & EMH 20080101

• Gene array and real time PCR analysis of the adrenal sensitivity to adrenocorticotropic hormone in pig.

  BMC genomics 20080101

• PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility.

  PPAR research 20080101

• Evolution of pharmacologic specificity in the pregnane X receptor.

  BMC evolutionary biology 20080101

• The use of a high-throughput luminescent method to assess CYP3A enzyme induction in cultured rat hepatocytes.

  In vitro cellular & developmental biology. Animal 20080101

• A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele.

  BMC medical genetics 20080101

• Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission.

  Physiological research 20080101

• Steroidogenic enzymes.

  Endocrine development 20080101

• Proteomic changes in rat hippocampus and adrenals following short-term sleep deprivation.

  Proteome science 20080101

• Neurosteroids in the Purkinje cell: biosynthesis, mode of action and functional significance.

  Molecular neurobiology 20080101

• Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha.

  BMC cancer 20080101

• Chemical markers for the quality control of herbal medicines: an overview.

  Chinese medicine 20080101

• An amphioxus orthologue of the estrogen receptor that does not bind estradiol: insights into estrogen receptor evolution.

  BMC evolutionary biology 20080101

• Gene expression profiles in liver of pigs with extreme high and low levels of androstenone.

  BMC veterinary research 20080101

• Yeast cell factories for fine chemical and API production.

  Microbial cell factories 20080101

• An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males.

  Journal of the International Society of Sports Nutrition 20080101

• The unfoldomics decade: an update on intrinsically disordered proteins.

  BMC genomics 20080101

• Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT.

  BMC genomics 20080101

• HOX cofactors expression and regulation in the human ovary.

  Reproductive biology and endocrinology : RB&E 20080101

• GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome.

  PloS one 20080101

• Neurosteroids enhance the viability of staurosporine and doxorubicin treated differentiated human neuroblastoma SH-SY5Y cells.

  Pharmacological reports : PR 20080101

• Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production.

  Reproductive biology and endocrinology : RB&E 20080101

• An acetylation/deacetylation cycle controls the export of sterols and steroids from S. cerevisiae.

  The EMBO journal 20071212

• The polymorphism of progesterone: stabilization of a 'disappearing' polymorph by co-crystallization.

  Journal of pharmaceutical sciences 20071201

• In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers.

  Molecular pharmacology 20071201

• Cholesterol sulphate affects production of steroid hormones by reducing steroidogenic acute regulatory protein level in adrenocortical cells.

  The Journal of endocrinology 20071201

• Steroidogenic acute regulatory (StAR) protein and cholesterol side-chain cleavage (P450scc) as molecular and cellular targets for 17alpha-ethynylestradiol in salmon previtellogenic oocytes.

  Chemical research in toxicology 20071201

• Metastin stimulates aldosterone synthesis in human adrenal cells.

  Reproductive sciences (Thousand Oaks, Calif.) 20071201

• Xenoandrogenic activity in serum differs across European and Inuit populations.

  Environmental health perspectives 20071201

• Effects of endocrine disruptors on dehydroepiandrosterone sulfotransferase and enzymes involved in PAPS synthesis: genomic and nongenomic pathways.

  Environmental health perspectives 20071201

• Influence of epipregnanolone on the modulation of rapid tolerance to ethanol by neurosteroids.

  Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20071201

• Adrenal steroid concentrations in children seven to seventeen years of age.

  Journal of pediatric endocrinology & metabolism : JPEM 20071201

• Effects of 17alpha-methyltestosterone exposure on steroidogenesis and cyclin-B mRNA expression in previtellogenic oocytes of Atlantic cod (Gadus morhua).

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20071101

• The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues.

  Molecular pharmacology 20071101

• Progesterone metabolism in bovine endometrial cells and the effect of metabolites on the responsiveness of the cells to OT-stimulation of PGF2alpha.

  Steroids 20071101

• Protein kinase G-mediated stimulation of basal Leydig cell steroidogenesis.

  American journal of physiology. Endocrinology and metabolism 20071101

• Steroidogenic acute regulatory protein expression and pregnenolone synthesis in rat astrocyte cultures.

  Journal of neuroendocrinology 20071101

• Effect and mechanism of cadmium on the progesterone synthesis of ovaries.

  Toxicology 20071008

• The role of polyester interstitium and aldosterone during structural development of renal tubules in serum-free medium.

  Biomaterials 20071001

• Neurosteroid regulation of central nervous system development.

  Pharmacology & therapeutics 20071001

• Effects of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) hull extracts on the secretion of progesterone and estradiol in vivo and in vitro.

  Experimental biology and medicine (Maywood, N.J.) 20071001

• Reversal of lindane-induced impairment of step-down passive avoidance and oxidative stress by neurosteroids in rats.

  Toxicology 20070924

• PREGS induces LTP in the hippocampal dentate gyrus of adult rats via the tyrosine phosphorylation of NR2B coupled to ERK/CREB [corrected] signaling.

  Journal of neurophysiology 20070901

• A conserved tyrosine in the beta2 subunit M4 segment is a determinant of gamma-aminobutyric acid type A receptor sensitivity to propofol.

  Anesthesiology 20070901

• Genetics of aging in Caenorhabditis elegans.

  PLoS genetics 20070901

• Effect of complexes of apolipoprotein A-I with tetrahydrocortisol and pregnenolone on protein biosynthesis in rat hepatocytes culture.

  Bulletin of experimental biology and medicine 20070901

• Effects of butyltin compounds on follicular steroidogenesis in the bullfrog(Rana catesbeiana).

  Environmental toxicology and pharmacology 20070901

• 22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells.

  Neuroscience 20070824

• Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.

  Biochemistry 20070807

• Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of Leydig cells in adult male mouse.

  Endocrinology 20070801

• Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics.

  The Journal of pharmacology and experimental therapeutics 20070801

• Acute effects of neurosteroids in a rodent model of primary paroxysmal dystonia.

  Hormones and behavior 20070801

• [Studies on chemical constituents of rhizomes of Ligusticum chuanxiong].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070801

• Treatment of premenstrual dysphoric disorder (PMDD) with a novel formulation of drospirenone and ethinyl estradiol.

  Therapeutics and clinical risk management 20070801

• Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6).

  The Journal of biological chemistry 20070706

• 17beta-estradiol synthesis in the adult male rat retina.

  Experimental eye research 20070701

• Transcriptional regulation of human CYP11A1 in gonads and adrenals.

  Journal of biomedical science 20070701

• The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes.

  Journal of molecular medicine (Berlin, Germany) 20070601

• Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1).

  Journal of toxicology and environmental health. Part A 20070601

• An integrated analysis of the effects of Esculentin 1-21 on Saccharomyces cerevisiae.

  Biochimica et biophysica acta 20070601

• Delta 5-3beta-hydroxysteroid dehydrogenase (3 beta HSD) from Digitalis lanata. Heterologous expression and characterisation of the recombinant enzyme.

  Planta medica 20070601

• Intrahippocampal allopregnanolone decreases voluntary chronic alcohol consumption in non-selected rats.

  Progress in neuro-psychopharmacology & biological psychiatry 20070509

• Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry.

  Endocrinology 20070501

• Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy.

  Cellular and molecular life sciences : CMLS 20070501

• Structural and chemical profiling of the human cytosolic sulfotransferases.

  PLoS biology 20070501

• Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells.

  The Journal of steroid biochemistry and molecular biology 20070501

• Cholesterol binding does not predict activity of the steroidogenic acute regulatory protein, StAR.

  The Journal of biological chemistry 20070406

• Differences in blood pregnenolone and dehydroepiandrosterone levels between schizophrenia patients and healthy subjects.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070401

• Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis.

  Endocrinology 20070401

• Determination of 17alpha-hydroxypregnenolone sulfate and its application in diagnostics.

  Steroids 20070401

• Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver.

  The Journal of biological chemistry 20070330

• Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.

  Drug metabolism and disposition: the biological fate of chemicals 20070301

• Luteinizing hormone receptor mediates neuronal pregnenolone production via up-regulation of steroidogenic acute regulatory protein expression.

  Journal of neurochemistry 20070301

• Enzyme-assisted synthesis and characterization of glucuronide conjugates of neuroactive steroids.

  Steroids 20070301

• Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol.

  The Journal of steroid biochemistry and molecular biology 20070301

• 3Beta-hydroxysteroids and pregnenolone sulfate inhibit recombinant rat GABA(A) receptor through different channel property.

  European journal of pharmacology 20070227

• Differential regulation of ionotropic glutamate receptors.

  Biophysical journal 20070215

• Intracellular sterol transport in eukaryotes, a connection to mitochondrial function?

  Biochimie 20070201

• The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

  Drug metabolism and disposition: the biological fate of chemicals 20070201

• Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor.

  Molecular pharmacology 20070201

• Hormonal regulation of the steroidogenic acute regulatory protein (StAR) in gonadal tissues of the Atlantic croaker (Micropogonias undulatus).

  General and comparative endocrinology 20070201

• Cytochrome P450 side-chain cleavage: insights gained from homology modeling.

  Molecular and cellular endocrinology 20070201

• A steroid hormone that extends the lifespan of Caenorhabditis elegans.

  Aging cell 20070201

• Kinetic characterization of the oxidation of esculetin by polyphenol oxidase and peroxidase.

  Bioscience, biotechnology, and biochemistry 20070201

• Cardiometabolic aspects of polycystic ovarian syndrome.

  Vascular health and risk management 20070201

• Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.

  Oncogene 20070111

• In silico prediction of pregnane X receptor activators by machine learning approaches.

  Molecular pharmacology 20070101

• Sex differences in steroid modulation of ethanol withdrawal in male and female rats.

  The Journal of pharmacology and experimental therapeutics 20070101

• Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450C17) in the frog brain and pituitary.

  Journal of neurochemistry 20070101

• Human chorionic gonadotropin does not alter patterns of adrenal androgen secretion in primary human adrenal reticularis and fasciculata cell culture.

  Menopause (New York, N.Y.) 20070101

• Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors.

  BMC evolutionary biology 20070101

• Steroid pregnenolone sulfate enhances NMDA-receptor-independent long-term potentiation at hippocampal CA1 synapses: role for L-type calcium channels and sigma-receptors.

  Hippocampus 20070101

• Regulation of metabolic networks by small molecule metabolites.

  BMC bioinformatics 20070101

• Cloning, tissue expression, and inducibility of CYP 3A79 from sea bass (Dicentrarchus labrax).

  Journal of biochemical and molecular toxicology 20070101

• The Genetic Basis of the Polycystic Ovary Syndrome: A Literature Review Including Discussion of PPAR-gamma.

  PPAR research 20070101

• Screening candidate longevity therapeutics using gene-expression arrays.

  Gerontology 20070101

• Circulating levels of pregnanolone isomers during the third trimester of human pregnancy.

  The Journal of steroid biochemistry and molecular biology 20070101

• Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids.

  PloS one 20070101

• Effect of cytochrome P450 (CYP) inducers on caffeine metabolism in the rat.

  Pharmacological reports : PR 20070101

• Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre- and perimenopausal women with active rheumatoid arthritis: a pilot case-control study.

  Arthritis research & therapy 20070101

• [Acylhydrazones of 20-keto steroids and their transformations: I. Synthesis and properties of 1'-acyl-substituted 3'-methylandrosteno[16,17-d]pyrazolines].

  Bioorganicheskaia khimiia 20070101

• Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response.

  Current pharmaceutical design 20070101

• In vitro exposure of porcine granulosa cells to the phytoestrogens genistein and daidzein: effects on the biosynthesis of reproductive steroid hormones.

  Reproductive toxicology (Elmsford, N.Y.) 20070101

• Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase.

  Drug metabolism reviews 20070101

• Neuroactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats.

  Psychoneuroendocrinology 20070101

• Gene expression profiles in testis of pigs with extreme high and low levels of androstenone.

  BMC genomics 20070101

• Functional evolution of the vitamin D and pregnane X receptors.

  BMC evolutionary biology 20070101

• Inhibitors of steroidal cytochrome p450 enzymes as targets for drug development.

  Recent patents on anti-cancer drug discovery 20070101

• Pregnenolone and dexamethasone, modulators of cytochrome P450-3A, not increase but reduce urinary alpha-CEHC excretion in rats.

  BioFactors (Oxford, England) 20070101

• The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease.

  Biological psychiatry 20061215

• A kinetic study on the lactoperoxidase catalyzed oxidation of estrogens.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20061201

• Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20061201

• Low concentrations mono-butyl phthalate stimulates steroidogenesis by facilitating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1).

  Chemico-biological interactions 20061201

• p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile.

  Toxicological sciences : an official journal of the Society of Toxicology 20061201

• Human cytosolic sulfotransferase 2B1: isoform expression, tissue specificity and subcellular localization.

  The Journal of steroid biochemistry and molecular biology 20061201

• Why are mineralocorticoid receptor antagonists cardioprotective?

  Naunyn-Schmiedeberg's archives of pharmacology 20061201

• Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior.

  Dialogues in clinical neuroscience 20061201

• In vivo inhibition of steroidogenic acute regulatory protein expression by dexamethasone parallels induction of the negative transcription factor DAX-1.

  Endocrine 20061201

• Analysis of hormonal steroids in fish plasma and bile by coupling solid-phase extraction to GC/MS.

  Analytical and bioanalytical chemistry 20061101

• Modification of OATP2B1-mediated transport by steroid hormones.

  Molecular pharmacology 20061101

• Neurosteroid-induced enhancement of short-term facilitation involves a component downstream from presynaptic calcium in hippocampal slices.

  The Journal of physiology 20061101

• Synthesis of steroidal lactone by penicillium citreo-viride.

  Steroids 20061101

• Effects of crude adlay hull acetone extract on corticosterone release from rat zona fasciculata-reticularis cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20061101

• Long-chain fatty acids induce lipid droplet formation in a cultured human hepatocyte in a manner dependent of Acyl-CoA synthetase.

  Biological & pharmaceutical bulletin 20061101

• Proliferative processes within the equine corpus luteum may depend on paracrine progesterone actions.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101

• Intradermal pregnenolone sulfate attenuates capsaicin-induced nociception in rats.

  Biochemical and biophysical research communications 20061020

• In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action?

  Toxicology and applied pharmacology 20061015

• Neurosteroid modulation of recombinant rat alpha5beta2gamma2L and alpha1beta2gamma2L GABA(A) receptors in Xenopus oocyte.

  European journal of pharmacology 20061010

• Improving the outcome of patients with castration-resistant prostate cancer through rational drug development.

  British journal of cancer 20061009

• Role of calcium channels in cadmium-induced disruption of cortisol synthesis in rainbow trout (Oncorhynchus mykiss).

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061001

• Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein.

  Biochimica et biophysica acta 20061001

• Neurosteroid pregnenolone sulfate enhances glutamatergic synaptic transmission by facilitating presynaptic calcium currents at the calyx of Held of immature rats.

  The European journal of neuroscience 20061001

• A fission yeast-based test system for the determination of IC50 values of anti-prostate tumor drugs acting on CYP21.

  Journal of enzyme inhibition and medicinal chemistry 20061001

• Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma.

  Neurochemistry international 20060901

• Oxygen concentration is an important factor for modulating progesterone synthesis in bovine corpus luteum.

  Endocrinology 20060901

• Strain differences of neurosteroid levels in mouse brain.

  Steroids 20060901

• The pesticide heptachlor affects steroid hormone secretion in isolated follicular and luteal cells of rat.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20060901

• Full automation of solid-phase microextraction/on-fiber derivatization for simultaneous determination of endocrine-disrupting chemicals and steroid hormones by gas chromatography-mass spectrometry.

  Analytical and bioanalytical chemistry 20060901

• Rational proteomics V: structure-based mutagenesis has revealed key residues responsible for substrate recognition and catalysis by the dehydrogenase and isomerase activities in human 3beta-hydroxysteroid dehydrogenase/isomerase type 1.

  The Journal of steroid biochemistry and molecular biology 20060901

• Neurosteroid biosynthesis in the quail brain: a review.

  Journal of experimental zoology. Part A, Comparative experimental biology 20060901

• Homozygous mutation of P450 side-chain cleavage enzyme gene (CYP11A1) in 46, XY patient with adrenal insufficiency, complete sex reversal, and agenesis of corpus callosum.

  The Journal of clinical endocrinology and metabolism 20060801

• Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age.

  The Journal of clinical endocrinology and metabolism 20060801

• Development and performance evaluation of a tandem mass spectrometry assay for 4 adrenal steroids.

  Clinical chemistry 20060801

• Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis.

  Pharmacology, biochemistry, and behavior 20060801

• Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection.

  Pharmacology, biochemistry, and behavior 20060801

• Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?

  Pharmacology, biochemistry, and behavior 20060801

• Expression of cytochrome P450scc in Escherichia coli cells: intracellular location and interaction with bacterial redox proteins.

  Biochemistry. Biokhimiia 20060801

• Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions.

  Pharmacology, biochemistry, and behavior 20060801

• Sulfated steroids as endogenous neuromodulators.

  Pharmacology, biochemistry, and behavior 20060801

• Sigma1 receptor ligands and related neuroactive steroids interfere with the cocaine-induced state of memory.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060701

• Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060701

• Gonadotropin regulation of testosterone production by primary cultured theca and granulosa cells of Atlantic croaker: I. Novel role of CaMKs and interactions between calcium- and adenylyl cyclase-dependent pathways.

  General and comparative endocrinology 20060701

• Modulation of neurosteroid production in human neuroblastoma cells by Alzheimer's disease key proteins.

  Journal of neurobiology 20060701

• Microbial metabolism of methyl protodioscin by Aspergillus niger culture--a new androstenedione producing way from steroid.

  The Journal of steroid biochemistry and molecular biology 20060701

• Capillary liquid chromatography-microchip atmospheric pressure chemical ionization-mass spectrometry.

  Lab on a chip 20060701

• Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity.

  Xenobiotica; the fate of foreign compounds in biological systems 20060701

• Neurosteroids in nicotine and morphine dependence.

  Psychopharmacology 20060601

• Neuroactive steroids are altered in schizophrenia and bipolar disorder: relevance to pathophysiology and therapeutics.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060601

• Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol.

  Psychopharmacology 20060601

• Neuroactive steroids, negative affect, and nicotine dependence severity in male smokers.

  Psychopharmacology 20060601

• Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes.

  Psychopharmacology 20060601

• The neuroactive steroid pregnenolone sulfate stimulates the release of gonadotropin-releasing hormone from GT1-7 hypothalamic neurons, through N-methyl-D-aspartate receptors.

  Endocrinology 20060601

• Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy.

  Neuropharmacology 20060601

• Replacement of alanine with asparagic acid at position 203 in human steroidogenic acute regulatory protein impairs the ability to enhance steroidogenesis in vitro.

  Endocrine journal 20060601

• Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study.

  Psychopharmacology 20060601

• Induction of human UDP-glucuronosyltransferase 1A1 by cortisol-GR.

  Molecular biology reports 20060601

• Ovulation, pregnancy, placentation and husbandry in the African elephant (Loxodonta africana).

  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20060529

• [Lipoid adrenal hyperplasia].

  Nihon rinsho. Japanese journal of clinical medicine 20060528

• [20,22 Desmolase deficiency].

  Nihon rinsho. Japanese journal of clinical medicine 20060528

• Ca2+ signal stimulates the expression of steroidogenic acute regulatory protein and steroidogenesis in bovine adrenal fasciculata-reticularis cells.

  Life sciences 20060515

• Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate.

  British journal of pharmacology 20060501

• Decreased neuroactive steroids induced by combined oral contraceptive pills are not associated with mood changes.

  Fertility and sterility 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Cloning and characterization of a cDNA encoding cholesterol side-chain cleavage cytochrome P450 (CYP11A1): tissue-distribution and changes in the transcript abundance in ovarian tissue of Japanese eel, Anguilla japonica, during artificially induced sexual development.

  The Journal of steroid biochemistry and molecular biology 20060501

• Gonadotropin stimulation of steroid synthesis and metabolism in the Rana pipiens ovarian follicle: sequential changes in endogenous steroids during ovulation, fertilization and cleavage stages.

  The Journal of steroid biochemistry and molecular biology 20060501

• Rapid action of pesticides on cytosolic calcium concentrations in cultures of human umbilical vein endothelial cells.

  Reproductive toxicology (Elmsford, N.Y.) 20060401

• Injury elicited increase in spinal cord neurosteroid content analyzed by gas chromatography mass spectrometry.

  Endocrinology 20060401

• Cholesterol-metabolizing cytochromes P450.

  Drug metabolism and disposition: the biological fate of chemicals 20060401

• Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons.

  British journal of pharmacology 20060401

• Evaluation of CD detection in an HPLC system for analysis of DHEA and related steroids.

  Analytical and bioanalytical chemistry 20060401

• Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men.

  Archives of general psychiatry 20060401

• Direct electrochemistry of human, bovine and porcine cytochrome P450c17.

  Journal of molecular endocrinology 20060401

• [Testosterone synthesis].

  Nihon rinsho. Japanese journal of clinical medicine 20060401

• [Structure, productive part and synthesis of progesterone].

  Nihon rinsho. Japanese journal of clinical medicine 20060401

• Steroidogenesis in zebrafish and mouse models.

  Molecular and cellular endocrinology 20060327

• Effect of isopregnanolone on rapid tolerance to the anxiolytic effect of ethanol.

  Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20060301

• Cloning, characterization and tissue expression of rat SULT2B1a and SULT2B1b steroid/sterol sulfotransferase isoforms: divergence of the rat SULT2B1 gene structure from orthologous human and mouse genes.

  Gene 20060215

• Generation of specific antibodies and their use to characterize sex differences in four rat P450 3A enzymes following vehicle and pregnenolone 16alpha-carbonitrile treatment.

  Archives of biochemistry and biophysics 20060215

• Solid-phase microextraction with on-fiber silylation for simultaneous determinations of endocrine disrupting chemicals and steroid hormones by gas chromatography-mass spectrometry.

  Journal of chromatography. A 20060203

• Mechanisms of digoxin and digitoxin on the production of corticosterone in zona fasciculata-reticularis cells of ovariectomized rats.

  Journal of cellular biochemistry 20060201

• Developmental changes of serum steroids produced by cytochrome P450c17 in rat.

  Steroids 20060201

• Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells.

  Immunology and cell biology 20060201

• Alcohol increases efficacy of immature synapses in a neurosteroid-dependent manner.

  The European journal of neuroscience 20060201

• Cytotoxic constituents from Solanum lyratum.

  Archives of pharmacal research 20060201

• Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement.

  Nature 20060126

• In vitro steroid production by adrenals and kidney-gonads from embryonic southern snow skinks (Niveoscincus microlepidotus): implications for the control of the timing of parturition?

  General and comparative endocrinology 20060115

• A sensitive and selective HPLC/ESI-MS/MS assay for the simultaneous quantification of 16-dehydropregnenolone and its major metabolites in rabbit plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102

• Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain.

  Endocrinology 20060101

• Subtype-dependence of N-methyl-D-aspartate receptor modulation by pregnenolone sulfate.

  Neuroscience 20060101

• Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: synaptocrinology.

  Neuroscience 20060101

• Steroidogenic acute regulatory protein in the brain.

  Neuroscience 20060101

• Cytochrome P450 expression-induction profile and chemically mediated alterations of the WIF-B9 cell line.

  Biology of the cell 20060101

• Studies of the role of steroid hormone in the regulation of oocyte maturation in cattle.

  Reproductive biology and endocrinology : RB&E 20060101

• Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor.

  Annals of clinical microbiology and antimicrobials 20060101

• Estrogen receptors alpha and beta in rat placenta: detection by RT-PCR, real time PCR and Western blotting.

  Reproductive biology and endocrinology : RB&E 20060101

• The role of steroids in follicular growth.

  Reproductive biology and endocrinology : RB&E 20060101

• Neurogenic pain and steroid synthesis in the spinal cord.

  Journal of molecular neuroscience : MN 20060101

• Sexually dimorphic gene expression that overlaps maturation of type II pneumonocytes in fetal mouse lungs.

  Reproductive biology and endocrinology : RB&E 20060101

• Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells.

  Drug metabolism reviews 20060101

• Cholesterol sensing, trafficking, and esterification.

  Annual review of cell and developmental biology 20060101

• Endogenous neuroprotective factors: neurosteroids.

  Pharmacological reports : PR 20060101

• Role of cytochrome p450 in synaptocrinology: endogenous estrogen synthesis in the brain hippocampus.

  Drug metabolism reviews 20060101

• Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease.

  Molecular neurodegeneration 20060101

• GABA(A) receptor inhibition - site matters!

  Acta physiologica (Oxford, England) 20060101

• Pregnenolone sulphate and Zn2+ inhibit recombinant rat GABA(A) receptor through different channel property.

  Acta physiologica (Oxford, England) 20060101

• Chemical and metabolic transformations of selected bile acids.

  European journal of drug metabolism and pharmacokinetics 20060101

• Local neurosteroid production in the hippocampus: influence on synaptic plasticity of memory.

  Neuroendocrinology 20060101

• The celiac ganglion modulates LH-induced inhibition of androstenedione release in late pregnant rat ovaries.

  Reproductive biology and endocrinology : RB&E 20060101

• Presynaptic modulation of synaptic transmission by pregnenolone sulfate as studied by optical recordings.

  Journal of neurophysiology 20051201

• Expression and regulation of progestin membrane receptors in the rat corpus luteum.

  Endocrinology 20051201

• Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects.

  International journal of molecular medicine 20051201

• Cloning and characterization of cDNAs encoding steroidogenic acute regulatory protein from freshwater stingrays (Potamotrygon spp.).

  Journal of molecular endocrinology 20051201

• The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain.

  Pharmacology, biochemistry, and behavior 20051201

• The intrahippocampal administration of the neurosteroid allopregnanolone blocks the audiogenic seizures induced by nicotine.

  Brain research 20051116

• Involvement of GABAA receptor modulating neuroactive steroids in patients with social phobia.

  Psychiatry research 20051115

• Characterization of the guinea pig 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4-isomerase expressed in the adrenal gland and gonads.

  The Journal of steroid biochemistry and molecular biology 20051101

• Low concentrations of neuroactive steroids alter kinetics of [3H]ifenprodil binding to the NMDA receptor in rat frontal cortex.

  British journal of pharmacology 20051101

• Microbial hydroxylation of pregnenolone derivatives.

  Chemical & pharmaceutical bulletin 20051101

• Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis.

  The Journal of endocrinology 20051101

• A treatise on hazards of endocrine disruptors and tool to evaluate them.

  Indian journal of experimental biology 20051101

• 3alpha-reduced neuroactive steroids and their precursors during pregnancy and the postpartum period.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20051101

• [Effects of morphine dependence on the levels of neurosteroids in rat brain].

  Yao xue xue bao = Acta pharmaceutica Sinica 20051101

• Intrahippocampal nicotine and neurosteroids effects on the anxiety-like behaviour in voluntary and chronic alcohol-drinking rats.

  Behavioural brain research 20051014

• A study of a dendritic marker, microtubule-associated protein 2 (MAP-2), in rats neonatally treated neurosteroids, pregnenolone and dehydroepiandrosterone (DHEA).

  Neuroscience letters 20051007

• Enzyme kinetics of zearalenone biotransformation: pH and cofactor effects.

  Archives of toxicology 20051001

• Adrenal and gonadal hormone variations during a febrile attack in a woman with tumor necrosis factor receptor-associated periodic syndrome.

  The Journal of clinical endocrinology and metabolism 20051001

• Identification of a single nucleotide polymorphism in porcine testis cytochrome P450-c17 (CYP17) and its effect on steroidogenesis.

  Biochemical genetics 20051001

• Enzymic conversion of 3beta-hydroxy-5-ene-steroids and their sulfates to 3-oxo-4-ene-steroids for increasing sensitivity in LC-APCI-MS.

  Journal of pharmaceutical and biomedical analysis 20050915

• A novel mutation L260P of the steroidogenic acute regulatory protein gene in three unrelated patients of Swiss ancestry with congenital lipoid adrenal hyperplasia.

  The Journal of clinical endocrinology and metabolism 20050901

• Neurosteroid pregnenolone sulfate inhibits stimulus-evoked EPSC via presynaptic inhibition of protein kinase A in rat prelimbic cortical neurons.

  Neuropharmacology 20050901

• Effect of neurosteroids on the retinal gabaergic system and electroretinographic activity in the golden hamster.

  Journal of neurochemistry 20050901

• Steroid signalling in the ovarian surface epithelium.

  Trends in endocrinology and metabolism: TEM 20050901

• Antiviral effect of dehydroepiandrosterone on Japanese encephalitis virus infection.

  The Journal of general virology 20050901

• Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus.

  Journal of neuroendocrinology 20050901

• Effects of intrahippocampal nicotine and neurosteroid administration on withdrawal in voluntary and chronic alcohol-drinking rats.

  Alcoholism, clinical and experimental research 20050901

• CAR and PXR: xenosensors of endocrine disrupters?

  Chemico-biological interactions 20050815

• The effect of 17beta estradiol withdrawal on the level of brain and peripheral neurosteroids in ovarectomized rats.

  Neuroscience letters 20050801

• Hypocorticism and interrenal hyperplasia are not directly related to masculinization in XX mas(-1)/mas(-1) carp, Cyprinus carpio.

  General and comparative endocrinology 20050801

• Human renal mesangial cells produce aldosterone in response to low-density lipoprotein (LDL).

  The Journal of steroid biochemistry and molecular biology 20050801

• Dose-response effects of phytoestrogens on the activity and expression of 3beta-hydroxysteroid dehydrogenase and aromatase in human granulosa-luteal cells.

  The Journal of steroid biochemistry and molecular biology 20050801

• [Pregnenolone, pregnenolone sulfate].

  Nihon rinsho. Japanese journal of clinical medicine 20050801

• Pregnenolone sulfate acts through a G-protein-coupled sigma1-like receptor to enhance short term facilitation in adult hippocampal neurons.

  European journal of pharmacology 20050725

• Ultrastructural analysis of guided nerve regeneration using progesterone- and pregnenolone-loaded chitosan prostheses.

  Journal of biomedical materials research. Part B, Applied biomaterials 20050701

• Potential role for human cytochrome P450 3A4 in estradiol homeostasis.

  Endocrinology 20050701

• Site-directed mutations (Asp405Ile and Glu124Ile) in cytochrome P450scc: effect on adrenodoxin binding.

  Journal of cellular biochemistry 20050701

• Synthesis of some new steroidal [16alpha,17alpha-d]-isoxazolines.

  Steroids 20050701

• Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction.

  Steroids 20050701

• The identification and simultaneous quantification of 7-hydroxylated metabolites of pregnenolone, dehydroepiandrosterone, 3beta,17beta-androstenediol, and testosterone in human serum using gas chromatography-mass spectrometry.

  The Journal of steroid biochemistry and molecular biology 20050701

• Effects of sub-lethal levels of dichlorodiphenyltrichloroethane and dichlorodiphenyldichloroethylene on in vitro steroid biosynthesis by ovarian follicles or steroid metabolism by embryos of rainbow trout (Oncorhynchus mykiss).

  Aquatic toxicology (Amsterdam, Netherlands) 20050701

• Differential expression and function of beacon in the rat adrenal cortex and medulla.

  International journal of molecular medicine 20050701

• Synthesis of free and sulphoconjugated 16-androstene steroids by the Leydig cells of the mature domestic boar.

  The Journal of steroid biochemistry and molecular biology 20050701

• Response of rat fasciculata-reticularis cells in primary culture to bacterial lipopolysaccharide.

  Microbes and infection 20050701

• Identification and immunohistochemical localization of Sulfotransferase 2B1b (SULT2B1b) in human lung.

  Biochimica et biophysica acta 20050620

• Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I.

  Biochemical and biophysical research communications 20050617

• Novel type of Gq/11 protein-coupled neurosteroid receptor sensitive to endocrine disrupting chemicals in mast cell line (RBL-2H3).

  British journal of pharmacology 20050601

• The environmental estrogen bisphenol a inhibits estradiol-induced hippocampal synaptogenesis.

  Environmental health perspectives 20050601

• Blocking BRE expression in Leydig cells inhibits steroidogenesis by down-regulating 3beta-hydroxysteroid dehydrogenase.

  The Journal of endocrinology 20050601

• Short-term lab exposures of immature rainbow trout (Oncorhynchus mykiss) to sulfite and kraft pulp-mill effluents: effects on oxidative stress and circulating sex steroids.

  Environmental toxicology and chemistry 20050601

• Changes in peripheral benzodiazepine receptors in patients with bipolar disorder.

  Neuropsychiatric disease and treatment 20050601

• Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

  Journal of medicinal chemistry 20050505

• The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion.

  Molecular endocrinology (Baltimore, Md.) 20050501

• Neurosteroid enhances glutamate release in rat prelimbic cortex via activation of alpha1-adrenergic and sigma1 receptors.

  Cellular and molecular life sciences : CMLS 20050501

• The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050501

• Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23.

  Biochemical pharmacology 20050501

• Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure.

  Journal of hepatology 20050501

• Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons.

  The European journal of neuroscience 20050501

• Non-genomic effect of steroids on oxytocin-stimulated intracellular mobilization of calcium and on prostaglandin F2alpha and E2 secretion from bovine endometrial cells.

  Prostaglandins & other lipid mediators 20050501

• Sex differences in pregnenolone sulphate in the chick brain after training.

  Neuroreport 20050425

• CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs.

  Life sciences 20050415

• Progestagen profiles during the last trimester of gestation in Thoroughbred mares with normal or compromised pregnancies.

  Theriogenology 20050415

• Delayed autoregulation of glucose transport in vascular endothelial cells.

  Diabetologia 20050401

• Effect of glutamate and somatostatin-14 on basal and cAMP-stimulated steroidogenesis by rainbow trout (Oncorhynchus mykiss) ovarian follicles, in vitro.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20050401

• Progesterone synthesis by the human placenta.

  Placenta 20050401

• 17alpha-hydroxylase/17,20-Lyase deficiency due to novel compound heterozygote mutations: treatment for tall stature in a female with male pseudohermaphroditism and spontaneous puberty in her affected sister.

  Journal of pediatric endocrinology & metabolism : JPEM 20050401

• Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones.

  Brain research. Brain research reviews 20050401

• Is brain dehydroepiandrosterone synthesis modulated by free radicals in mice?

  Neuroscience letters 20050329

• Xenopus laevis CYP17 regulates androgen biosynthesis independent of the cofactor cytochrome b5.

  The Journal of biological chemistry 20050318

• Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050302

• Neurosteroid paradoxical enhancement of paired-pulse inhibition through paired-pulse facilitation of inhibitory circuits in dentate granule cells.

  Neuropharmacology 20050301

• Urinary marker of oral pregnenolone administration.

  Steroids 20050301

• New 5alpha-reductase inhibitors: in vitro and in vivo effects.

  Steroids 20050301

• The effects of the neurosteroids: pregnenolone, progesterone and dehydroepiandrosterone on muscarinic receptor-induced responses in Xenopus oocytes expressing M1 and M3 receptors.

  Naunyn-Schmiedeberg's archives of pharmacology 20050301

• [Determination of unconjugated neurosteroids in rat brain regions by liquid chromatography-negative atmospheric pressure ionization mass spectrometry].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050301

• Novel signaling stimulated by arsenite increases cholesterol metabolism through increases in unphosphorylated steroidogenic acute regulatory (StAR) protein.

  Molecular and cellular endocrinology 20050227

• Age-related expression of sigma1 receptors and antidepressant efficacy of a selective agonist in the senescence-accelerated (SAM) mouse.

  Journal of neuroscience research 20050215

• Measurement of steroid synthesis in zona glomerulosa cells by liquid chromatography-electrospray ionization-mass spectrometry: inhibition by nitric oxide.

  Analytical biochemistry 20050215

• Simultaneous substitution of phenylalanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residues abolishes the ability to transactivate the CYP3A23 promoter.

  The Journal of pharmacology and experimental therapeutics 20050201

• Effect of 3beta-hydroxysteroid dehydrogenase inhibition by trilostane on blood pressure in the Dahl salt-sensitive rat.

  American journal of physiology. Regulatory, integrative and comparative physiology 20050201

• Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria.

  Molecular endocrinology (Baltimore, Md.) 20050201

• A genetic isolate of congenital lipoid adrenal hyperplasia with atypical clinical findings.

  The Journal of clinical endocrinology and metabolism 20050201

• Interaction between allopregnanolone and pregnenolone sulfate in modulating GABA-mediated synaptic currents in neurons from the rat medial preoptic nucleus.

  Brain research 20050201

• Steroids, neuroactive steroids and neurosteroids in psychopathology.

  Progress in neuro-psychopharmacology & biological psychiatry 20050201

• Changes in bovine luteal progesterone metabolism in response to exogenous prostaglandin F(2alpha).

  Domestic animal endocrinology 20050201

• [Rare forms of female pseudohermaphroditism: when to investigate?].

  Arquivos brasileiros de endocrinologia e metabologia 20050201

• Histomorphological changes and cytochrome P450 isoforms expression and activities in precision-cut liver slices from neonatal rats.

  Toxicology 20050131

• pH-dependent Interactions of the carboxyl-terminal helix of steroidogenic acute regulatory protein with synthetic membranes.

  The Journal of biological chemistry 20050121

• Sex-specific modulation of anxiety and locomotion after neonatal exposure to pregnenolone sulfate.

  Physiology & behavior 20050117

• Effects of steroid hormones on synaptosomal ectonucleotidase activities from hippocampus and cortex of adult female rats.

  General and comparative endocrinology 20050115

• Solid-phase extraction of esculetin from the ash bark of Chinese traditional medicine by using molecularly imprinted polymers.

  Journal of chromatography. A 20050107

• Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia.

  The Journal of clinical investigation 20050103

• Male marmoset monkeys express an adrenal fetal zone at birth, but not a zona reticularis in adulthood.

  Endocrinology 20050101

• Pregnenolone sulfate enhances neurogenesis and PSA-NCAM in young and aged hippocampus.

  Neurobiology of aging 20050101

• Studies on neurosteroids XVII. Analysis of stress-induced changes in neurosteroid levels in rat brains using liquid chromatography-electron capture atmospheric pressure chemical ionization-mass spectrometry.

  Steroids 20050101

• Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study.

  Breast cancer research : BCR 20050101

• Steroidogenesis in ovarian follicles of chub mackerel, Scomber japonicus.

  Zoological science 20050101

• Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: an hypothesis.

  Reproductive biology and endocrinology : RB&E 20050101

• Steroid hormone metabolism by the chorioallantoic placenta of the mountain spiny lizard Sceloporus jarrovi as a possible mechanism for buffering maternal-fetal hormone exchange.

  Physiological and biochemical zoology : PBZ 20050101

• Pregnenolone and dehydroepiandrosterone administration in neonatal rats alters the immunoreactivity of hippocampal synapsin I, neuropeptide Y and glial fibrillary acidic protein at post-puberty.

  Neuroscience 20050101

• Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050101

• Gonadal steroids differentially modulate neurotoxicity of HIV and cocaine: testosterone and ICI 182,780 sensitive mechanism.

  BMC neuroscience 20050101

• Influence of progesterone, pregnenolone and 17beta-hydroxyprogesterone on the function of bovine luteal cells treated with luteinizing hormone, noradrenaline and prostaglandin E2.

  Polish journal of veterinary sciences 20050101

• Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

  BMC biochemistry 20050101

• Disorders of androgen synthesis--from cholesterol to dehydroepiandrosterone.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101

• Effect of streptozotocin-induced diabetes on the gene expression and biological activity of 3beta-hydroxysteroid dehydrogenase in the rat spinal cord.

  Neuroscience 20050101

• Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).

  Nuclear receptor 20050101

• The reported active metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits testosterone formation by cultured Leydig cells from neonatal rats.

  Reproductive toxicology (Elmsford, N.Y.) 20050101

• The neurosteroid pregnenolone sulfate neutralized the learning impairment induced by intrahippocampal nicotine in alcohol-drinking rats.

  Neuroscience 20050101

• Hormonally active nontransformed human ovarian cell culture from oophorectomy specimens: methods of development and initial characterization.

  Hormone research 20050101

• CYP17 gene polymorphism in relation to breast cancer risk: a case-control study.

  Breast cancer research : BCR 20050101

• Biochemical characterization of the Arctic char (Salvelinus alpinus) ovarian progestin membrane receptor.

  Reproductive biology and endocrinology : RB&E 20050101

• Induction and inhibition of oocyte maturation by EDCs in zebrafish.

  Reproductive biology and endocrinology : RB&E 20050101

• Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1.

  Methods in enzymology 20050101

• [The role of neurosteroids in the central nervous system function].

  Przeglad lekarski 20050101

• The hormonal fountains of youth: myth or reality?

  Journal of endocrinological investigation 20050101

• Regulation of steroidogenesis by p53 in macaque granulosa cells and H295R human adrenocortical cells.

  Endocrinology 20041201

• Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain.

  Journal of lipid research 20041201

• Enhanced acetaminophen toxicity by activation of the pregnane X receptor.

  Toxicological sciences : an official journal of the Society of Toxicology 20041201

• Pregnenolone sulfate enhances long-term potentiation in CA1 in rat hippocampus slices through the modulation of N-methyl-D-aspartate receptors.

  Journal of neuroscience research 20041201

• Functional characterization of mutant CYP17 genes isolated from a 17 alpha-hydroxylase/17,20-lyase-deficient patient.

  Metabolism: clinical and experimental 20041201

• The human cytochrome P4507B1: catalytic activity studies.

  The Journal of steroid biochemistry and molecular biology 20041201

• Mechanism underlying inhibition of the capsaicin receptor-mediated current by pregnenolone sulfate in rat dorsal root ganglion neurons.

  Brain research 20041119

• Molecular mechanism of pregnenolone sulfate action at NR1/NR2B receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041117

• Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23.

  Drug metabolism and disposition: the biological fate of chemicals 20041101

• Modulation of bradykinin-induced calcium changes in SH-SY5Y cells by neurosteroids and sigma receptor ligands via a shared mechanism.

  Synapse (New York, N.Y.) 20041101

• A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin.

  European journal of biochemistry 20041101

• Neurosteroids and sigma1 receptors, biochemical and behavioral relevance.

  Pharmacopsychiatry 20041101

• Testicular and blood steroid levels in aged men.

  Reproductive biology 20041101

• Overview of dehydroepiandrosterone biosynthesis.

  Seminars in reproductive medicine 20041101

• Role of StAR binding protein in steroidogenic cells.

  Endocrine research 20041101

• Promiscuous 3beta-hydroxysteroid dehydrogenases: testosterone 17beta-hydroxysteroid dehydrogenase activities of mouse type I and VI 3beta-hydroxysteroid dehydrogenases.

  Endocrine research 20041101

• The effect of Sutherlandia frutescens on steroidogenesis: confirming indigenous wisdom.

  Endocrine research 20041101

• The influence of the amino acid substitution I98K on the catalytic activity of baboon cytochrome P450 side-chain cleavage (CYP11A1).

  Endocrine research 20041101

• Effective StAR expression in mouse MA-10 and Y-1 cells: extensive overexpression does not increase basal or cAMP-induced steroidogenesis.

  Endocrine research 20041101

• [Determination of neurosteroids in rat brain regions by liquid chromatography/negative atomspheric pressure ionization mass spectrometry].

  Se pu = Chinese journal of chromatography 20041101

• Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion.

  The Journal of physiology 20041015

• Urinary analysis of 16(5alpha)-androsten-3alpha-ol by gas chromatography/combustion/isotope ratio mass spectrometry: implications in anti-doping analysis.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041015

• Effects of galectin-1 on regulation of progesterone production in granulosa cells from pig ovaries in vitro.

  Glycobiology 20041001

• Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16.

  PLoS biology 20041001

• Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain.

  Acta pharmacologica Sinica 20041001

• Use of complementary therapies among primary care clinic patients with arthritis.

  Preventing chronic disease 20041001

• Impact of neuropathic pain on the gene expression and activity of cytochrome P450side-chain-cleavage in sensory neural networks.

  Cellular and molecular life sciences : CMLS 20040901

• Fetal alcohol exposure alters neurosteroid levels in the developing rat brain.

  Journal of neurochemistry 20040901

• Prenatal diagnosis of P450 oxidoreductase deficiency (ORD): a disorder causing low pregnancy estriol, maternal and fetal virilization, and the Antley-Bixler syndrome phenotype.

  American journal of medical genetics. Part A 20040830

• Inhibitory effects of digoxin and digitoxin on corticosterone production in rat zona fasciculata-reticularis cells.

  British journal of pharmacology 20040801

• Serine 124 completes the Tyr, Lys and Ser triad responsible for the catalysis of human type 1 3beta-hydroxysteroid dehydrogenase.

  Journal of molecular endocrinology 20040801

• Pregnenolone sulfate potentiates the effects of NMDA on hippocampal alanine and dopamine.

  Pharmacology, biochemistry, and behavior 20040801

• Phosphorylation and function of the hamster adrenal steroidogenic acute regulatory protein (StAR).

  The Journal of steroid biochemistry and molecular biology 20040801

• Biochemical diagnosis of Antley-Bixler syndrome by steroid analysis.

  American journal of medical genetics. Part A 20040730

• A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor.

  Journal of medicinal chemistry 20040715

• Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone.

  Nature medicine 20040701

• Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids.

  The Journal of endocrinology 20040701

• Allopregnanolone in the brain and blood after disruption of the hypothalamic-pituitary-adrenal axis in fetal sheep.

  The Journal of endocrinology 20040701

• Failure of gamma-hydroxybutyric acid both to increase neuroactive steroid concentrations in adrenalectomized-orchiectomized rats and to induce tolerance to its steroidogenic effect in intact animals.

  Brain research 20040625

• Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer.

  British journal of cancer 20040614

• Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination.

  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20040601

• Sleep-wake states and cortical synchronization control by pregnenolone sulfate into the pedunculopontine nucleus.

  Journal of neuroscience research 20040601

• Neurosteroidogenesis in oligodendrocytes and Purkinje neurones of cerebellar cortex of dogs.

  Anatomia, histologia, embryologia 20040601

• Acute neurosteroid modulation and subunit isolation of the gamma-aminobutyric acidA receptor in the bullfrog, Rana catesbeiana.

  Journal of molecular endocrinology 20040601

• Lack of defects in androgen production in children with hypospadias.

  The Journal of clinical endocrinology and metabolism 20040601

• Evidence for 15alpha- and 7alpha-hydroxylase activity in gonadal tissue of the early-life stages of sea lampreys, Petromyzon marinus.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20040601

• The role of progesterone metabolism and androgen synthesis in renal blood pressure regulation.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040601

• The potential function of steroid sulphatase activity in steroid production and steroidogenic acute regulatory protein expression.

  The Biochemical journal 20040515

• Identification of 3beta,5beta-tetrahydroprogesterone, a progesterone metabolite, and its stimulatory action on preoptic neurons in the avian brain.

  Brain research 20040508

• Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation.

  Psychoneuroendocrinology 20040501

• Characterization of the convulsant action of pregnenolone sulfate.

  Neuropharmacology 20040501

• Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay.

  Biochemical pharmacology 20040501

• Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction.

  Experimental biology and medicine (Maywood, N.J.) 20040501

• Effect of glutamate on basal steroidogenesis by ovarian follicles of rainbow trout (Oncorhynchus mykiss).

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20040501

• Serum 17,20 beta-dihydroxy-4-pregnen-3-one Levels in pregnant and non-pregnant female rockfish, Sebastes schlegeli, viviparous teleost, and its production by post-ovulatory follicles.

  Zoological science 20040501

• Plasma levels of 7-hydroxylated dehydroepiandrosterone (DHEA) metabolites and selected amino-thiols as discriminatory tools of Alzheimer's disease and vascular dementia.

  Clinical chemistry and laboratory medicine 20040501

• [Effect of L-tyrosine on 3beta-HSD activity of rat luteal cells in vitro].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20040501

• Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism.

  The Journal of biological chemistry 20040430

• The use of the novel substrate-heme complex approach in the derivation of a representation of the active site of the enzyme complex 17alpha-hydroxylase and 17,20-lyase.

  Biochemical and biophysical research communications 20040409

• Effects of S-petasin on cyclic AMP production and enzyme activity of P450scc in rat zona fasciculata-reticularis cells.

  European journal of pharmacology 20040405

• Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria.

  Endocrinology 20040401

• Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: Part B: Reduced serum androgen levels in healthy premenopausal women with complaints of sexual dysfunction.

  International journal of impotence research 20040401

• Antinociceptive effects of peripheral benzodiazepine receptors.

  Pharmacology 20040401

• Steroid sulfatase (STS) expression in the human temporal lobe: enzyme activity, mRNA expression and immunohistochemistry study.

  Journal of neurochemistry 20040401

• Effects of progesterone and norethisterone on cephalexin uptake in the human intestinal cell line Caco-2.

  Biological & pharmaceutical bulletin 20040401

• The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells.

  Journal of molecular endocrinology 20040401

• Chimerogenesis in estimation of specificity and pathway directions for cytochrome p45017alpha catalyzed reactions.

  Biochemistry. Biokhimiia 20040401

• Histone deacetylase inhibitor stimulate CYP3A4 proximal promoter activity in HepG2 cells.

  Archives of pharmacal research 20040401

• The control by angiotensin II of cholesterol supply for aldosterone biosynthesis.

  Molecular and cellular endocrinology 20040331

• A comparative assessment of the adrenotoxic effects of cadmium in two teleost species, rainbow trout, Oncorhynchus mykiss, and yellow perch, Perca flavescens.

  Aquatic toxicology (Amsterdam, Netherlands) 20040330

• Feedback inhibition of steroidogenic acute regulatory protein expression in vitro and in vivo by androgens.

  Endocrinology 20040301

• Synthesis of [19- 2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates.

  Steroids 20040301

• Putative F-G loop is involved in association with the membrane in P450scc (P450 11A1).

  Molecular and cellular endocrinology 20040227

• Enhanced antidepressant efficacy of sigma1 receptor agonists in rats after chronic intracerebroventricular infusion of beta-amyloid-(1-40) protein.

  European journal of pharmacology 20040220

• [New steroid hormone family: endogenous cardiac glycosides and their role in physiologic and pathologic conditions].

  Orvosi hetilap 20040208

• Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.

  Endocrinology 20040201

• Elevated levels of some neuroactive progesterone metabolites, particularly isopregnanolone, in women with chronic fatigue syndrome.

  Psychoneuroendocrinology 20040201

• Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion.

  Hypertension (Dallas, Tex. : 1979) 20040201

• Downregulation of steroidogenic acute regulatory protein (StAR) gene expression by cyclic AMP in cultured Schwann cells.

  Glia 20040201

• Hormonal changes with cholesterol reduction: a double-blind pilot study.

  Journal of clinical pharmacy and therapeutics 20040201

• Congenital lipoid adrenal hyperplasia caused by a novel splicing mutation in the gene for the steroidogenic acute regulatory protein.

  The Journal of clinical endocrinology and metabolism 20040201

• [Congenital lipoid adrenal hyperplasia].

  Nihon rinsho. Japanese journal of clinical medicine 20040201

• Adrenal response to adrenocorticotropic hormone stimulation in patients with premenstrual syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040201

• Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats.

  European journal of pharmacology 20040126

• A capillary gas chromatography/mass spectrometric method for the quantification of hydroxysteroids in human plasma.

  Analytical biochemistry 20040101

• Adrenocorticotropin induces heme oxygenase-1 expression in adrenal cells.

  The Journal of endocrinology 20040101

• Expression of enzyme associated with steroid hormone synthesis and local production of steroid hormone in endometrial carcinoma cells.

  The Journal of endocrinology 20040101

• Adrenocortical hyperresponsiveness to corticotropin in polycystic ovary syndrome patients with adrenal androgen excess.

  Fertility and sterility 20040101

• Stereoselective reactions of (20R)-3,20-dihydroxy-(3',4'-dihydro-2'H-pyranyl)-5-pregnene derivatives form 27-nor-3,20,23,26-tetrahydroxy-cholesten-22-ones and related bromo ketones.

  Steroids 20040101

• Two prevalent CYP17 mutations and genotype-phenotype correlations in 24 Brazilian patients with 17-hydroxylase deficiency.

  The Journal of clinical endocrinology and metabolism 20040101

• The influence of parturition on the level and synthesis of sulfated and free neurosteroids in rats.

  Neuropsychobiology 20040101

• Expression of cytochrome P450scc mRNA and protein in the rat kidney from birth to adulthood.

  The Journal of steroid biochemistry and molecular biology 20040101

• Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: effect of the deciduoma reaction.

  Reproductive biology and endocrinology : RB&E 20040101

• Bioidentical hormone therapy: a review.

  Menopause (New York, N.Y.) 20040101

• Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis.

  Neuropsychobiology 20040101

• MAPREG: toward a novel approach of neuroprotection and treatment of Alzheimer's disease.

  Journal of molecular neuroscience : MN 20040101

• Ovariectomy and estradiol replacement therapy alters the adenine nucleotide hydrolysis in rat blood serum.

  Thrombosis research 20040101

• [Neurosteroids and their biological significance].

  Uspekhi fiziologicheskikh nauk 20040101

• [Determination of neurosteroids in rat brain by gas chromatography/mass spectrometry].

  Se pu = Chinese journal of chromatography 20040101

• Antisteroidogenic actions of hydrogen peroxide on rat Leydig cells.

  Journal of cellular biochemistry 20031215

• Differential effects of progestins on the brain.

  Maturitas 20031210

• Steroid structural requirements for stabilizing or disrupting lipid domains.

  Biochemistry 20031209

• CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding.

  The Journal of biological chemistry 20031205

• Effects of dehydroepiandrosterone on corticosterone release in rat zona fasciculata-reticularis cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20031201

• In vivo implants of beta-sitosterol cause reductions of reactive cholesterol pools in mitochondria isolated from gonads of male goldfish (Carassius auratus).

  General and comparative endocrinology 20031201

• Reference values for urinary steroids in Japanese newborn infants: gas chromatography/mass spectrometry in selected ion monitoring.

  Endocrine journal 20031201

• [Neurosteroids are 4th generation neuromessengers which are synthesized and enhance/suppress learning and memory in the brain].

  Seikagaku. The Journal of Japanese Biochemical Society 20031201

• Changes in the activities of hydroxysteroid dehydrogenases in mouse oocytes during meiotic maturation.

  The Journal of reproduction and development 20031201

• HPLC-UV method development and validation for 16-dehydropregnenolone, a novel oral hypolipidaemic agent, in rat biological matrices for application to pharmacokinetic studies.

  Journal of pharmaceutical and biomedical analysis 20031124

• Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.

  The Journal of biological chemistry 20031107

• CYP17 polymorphisms in relation to risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China.

  International journal of cancer 20031101

• Angiotensin II activates cholesterol ester hydrolase in bovine adrenal glomerulosa cells through phosphorylation mediated by p42/p44 mitogen-activated protein kinase.

  Endocrinology 20031101

• Neurosteroids in rat brain: extraction, isolation, and analysis by nanoscale liquid chromatography-electrospray mass spectrometry.

  Analytical chemistry 20031101

• Steroidogenic acute regulatory protein-binding protein cloned by a yeast two-hybrid system.

  The Journal of biological chemistry 20031024

• Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor.

  Journal of medicinal chemistry 20031023

• A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission.

  Molecular pharmacology 20031001

• Apparent pregnene hydroxylation deficiency (APHD): seeking the parentage of an orphan metabolome.

  Steroids 20031001

• Dehydroepiandrosterone with other neurosteroids preserve neuronal mitochondria from calcium overload.

  The Journal of steroid biochemistry and molecular biology 20031001

• [Effects of sigma receptor ligands on psychiatric disorders].

  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20031001

• Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by the enzyme aromatase.

  Journal of neurobiology 20030915

• Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase.

  The Journal of biological chemistry 20030912

• Steroids modulate N-methyl-D-aspartate-stimulated [3H] dopamine release from rat striatum via sigma receptors.

  The Journal of pharmacology and experimental therapeutics 20030901

• Cellular distribution and bioactivity of the key steroidogenic enzyme, cytochrome P450side chain cleavage, in sensory neural pathways.

  Journal of neurochemistry 20030901

• Steroidogenic acute regulatory protein in the rat brain: cellular distribution, developmental regulation and overexpression after injury.

  The European journal of neuroscience 20030901

• Aromatase: a neuroprotective enzyme.

  Progress in neurobiology 20030901

• Individual differences in cognitive aging: implication of pregnenolone sulfate.

  Progress in neurobiology 20030901

• Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands.

  Journal of medicinal chemistry 20030814

• Direct effect of propylthiouracil on progesterone release in rat granulosa cells.

  British journal of pharmacology 20030802

• Ontogeny of uteroplacental progestagen production in pregnant mares during the second half of gestation.

  Biology of reproduction 20030801

• DHEA, PREG and their sulphate derivatives on plasma and brain after CRH and ACTH administration.

  Neurochemical research 20030801

• Ghrelin, an endogenous ligand for the growth hormone-secretagogue receptor, is expressed in the human adrenal cortex.

  International journal of molecular medicine 20030801

• Corticosterone enhances adrenocorticotropin-induced calcium signals in bovine adrenocortical cells.

  Endocrinology 20030801

• Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20030801

• A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene.

  Drug metabolism and disposition: the biological fate of chemicals 20030801

• In vitro progesterone production by maternal and embryonic tissues during gestation in the southern snow skink (Niveoscincus microlepidotus).

  General and comparative endocrinology 20030801

• Effects of sex steroids, sex, and sexual maturity on cortisol production: an in vitro comparison of chinook salmon and rainbow trout interrenals.

  General and comparative endocrinology 20030801

• The organochlorine o,p'-DDD disrupts the adrenal steroidogenic signaling pathway in rainbow trout (Oncorhynchus mykiss).

  Toxicology and applied pharmacology 20030801

• Hormonal and developmental regulation of the mouse aldose reductase-like gene akr1b7 expression in Leydig cells.

  Journal of molecular endocrinology 20030801

• The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway.

  The Journal of clinical endocrinology and metabolism 20030801

• Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current.

  The Journal of physiology 20030801

• Ethanol rapidly induces steroidogenic acute regulatory protein expression and translocation in rat adrenal gland.

  European journal of pharmacology 20030725

• Neurosteroid modulation of the presynaptic NMDA receptors regulating hippocampal noradrenaline release in normal rats and those exposed prenatally to diazepam.

  Neurochemistry international 20030701

• Developmental expression of genes involved in neurosteroidogenesis: 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase in the rat brain.

  Endocrinology 20030701

• Transgenic mouse models of human CYP3A4 gene regulation.

  Molecular pharmacology 20030701

• The luteinizing hormone surge is preceded by an estrogen-induced increase of hypothalamic progesterone in ovariectomized and adrenalectomized rats.

  Neuroendocrinology 20030701

• Neurosteroid modulation of glutamate release in hippocampal neurons: lack of an effect of a chronic prenatal ethanol exposure paradigm.

  Alcoholism, clinical and experimental research 20030701

• The role of CYP 1A1 in the in vitro metabolism of pregnenolone by the liver of rainbow trout embryos.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030701

• Expression of 3beta-hydroxysteroid dehydrogenase and P450 side chain cleavage enzyme in the human uterine endometrium.

  Experimental & molecular medicine 20030630

• Ovarian modulators of 11beta-hydroxysteroid dehydrogenase (11beta HSD) activity in follicular fluid from bovine and porcine large antral follicles and spontaneous ovarian cysts.

  Biology of reproduction 20030601

• Gonadotropin-releasing hormone-agonist inhibits synthesis of nitric oxide and steroidogenesis by luteal cells in the pregnant rat.

  Biology of reproduction 20030601

• An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells.

  American journal of physiology. Regulatory, integrative and comparative physiology 20030601

• The pharmacology of spontaneously open alpha 1 beta 3 epsilon GABA A receptor-ionophores.

  Neuropharmacology 20030601

• Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1).

  The Journal of investigative dermatology 20030601

• The human kidney is a progesterone-metabolizing and androgen-producing organ.

  The Journal of clinical endocrinology and metabolism 20030601

• In vitro induction of cytochrome P4503A1-mRNA and testosterone hydroxylation in precision-cut liver slices from male and female rats.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030601

• Steroid production in toads.

  The Journal of steroid biochemistry and molecular biology 20030601

• Neuroactive steroids: new biomarkers of cognitive aging.

  The Journal of steroid biochemistry and molecular biology 20030601

• Neurosteroid secretion in panic disorder.

  Psychiatry research 20030530

• Inhibitory effects of bromocriptine on corticosterone secretion in male rats.

  European journal of pharmacology 20030509

• Oxidative stress and loss of cortisol secretion in adrenocortical cells of rainbow trout (Oncorhynchus mykiss) exposed in vitro to endosulfan, an organochlorine pesticide.

  Aquatic toxicology (Amsterdam, Netherlands) 20030508

• The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression.

  Toxicology 20030503

• Induction of cytochrome P450 3A by paclitaxel in mice: pivotal role of the nuclear xenobiotic receptor, pregnane X receptor.

  Drug metabolism and disposition: the biological fate of chemicals 20030501

• Sleep and endocrine regulation.

  Frontiers in bioscience : a journal and virtual library 20030501

• In vitro metabolism of pregnenolone to 7alpha-hydroxypregnenolone by rainbow trout embryos.

  General and comparative endocrinology 20030501

• Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030501

• Studies on neurosteroids XVI. Levels of pregnenolone sulfate in rat brains determined by enzyme-linked immunosorbent assay not requiring solvolysis.

  Biological & pharmaceutical bulletin 20030501

• Molecular cloning and characterization of 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase cDNAs from Japanese eel ovary.

  The Journal of steroid biochemistry and molecular biology 20030501

• 3 beta-hydroxysteroid dehydrogenase isomerase (3beta-HSD) activity in the rat sciatic nerve: kinetic analysis and regulation by steroids.

  The Journal of steroid biochemistry and molecular biology 20030501

• Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury.

  Neuroscience letters 20030403

• Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol.

  Journal of neurochemistry 20030401

• CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids.

  Drug metabolism and disposition: the biological fate of chemicals 20030401

• Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast.

  European journal of biochemistry 20030401

• 11-hydroxylation in the biosynthesis of endogenous ouabain: multiple implications.

  Annals of the New York Academy of Sciences 20030401

• Xenopus laevis ovarian CYP17 is a highly potent enzyme expressed exclusively in oocytes. Evidence that oocytes play a critical role in Xenopus ovarian androgen production.

  The Journal of biological chemistry 20030314

• Effects of amphetamine on steroidogenesis in MA-10 mouse Leydig tumor cells.

  Life sciences 20030314

• Does cholesterol use the mitochondrial contact site as a conduit to the steroidogenic pathway?

  BioEssays : news and reviews in molecular, cellular and developmental biology 20030301

• Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR.

  Molecular pharmacology 20030301

• Neuroactive steroid levels in patients with panic disorder.

  The American journal of psychiatry 20030301

• Phytoestrogens inhibit aromatase but not 17beta-hydroxysteroid dehydrogenase (HSD) type 1 in human granulosa-luteal cells: evidence for FSH induction of 17beta-HSD.

  Human reproduction (Oxford, England) 20030301

• Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit.

  Journal of neurophysiology 20030301

• Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor. Role of recombinant cytochrome b5 and P450 reductase.

  European journal of biochemistry 20030301

• Expression of cytochromes P450 3A in mouse lung: effects of dexamethasone and pregnenolone 16alpha-carbonitrile.

  Archives of toxicology 20030301

• Norbormide enhances late steps of steroid-hormone synthesis in rat and mouse adrenal cortex.

  The Journal of steroid biochemistry and molecular biology 20030301

• Effects of dioxin (2,3,7,8-TCDD) and PCDDs/PCDFs congeners mixture on steroidogenesis in human placenta tissue culture.

  Endocrine regulations 20030301

• Molecular dynamics of substrate complexes with hamster cytochrome P450c17 (CYP17): mechanistic approach to understanding substrate binding and activities.

  Biochimica et biophysica acta 20030217

• Hippocampal cytochrome P450s synthesize brain neurosteroids which are paracrine neuromodulators of synaptic signal transduction.

  Biochimica et biophysica acta 20030217

• Ghrelin and growth hormone secretagogue receptor are expressed in the rat adrenal cortex: Evidence that ghrelin stimulates the growth, but not the secretory activity of adrenal cells.

  FEBS letters 20030211

• Synthesis of 21,21-difluoro-3 beta-hydroxy-20-methylpregna-5,20-diene and 5,16,20-triene as potential inhibitors of steroid C17(20) lyase.

  Bioorganic & medicinal chemistry 20030206

• Nicotine-induced changes in cerebrocortical neuroactive steroids and plasma corticosterone concentrations in the rat.

  Pharmacology, biochemistry, and behavior 20030201

• Blood steroid profile and in vitro steroidogenesis by ovarian follicles and testis fragments of adult sea lamprey, Petromyzon marinus.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20030201

• Serum levels of pregnenolone and 17-hydroxypregnenolone in patients with rheumatoid arthritis and systemic lupus erythematosus: relation to other adrenal hormones.

  The Journal of rheumatology 20030201

• Effects of a phytosterol mixture on male fish plasma lipoprotein fractions and testis P450scc activity.

  General and comparative endocrinology 20030201

• Detection and characterization of 20-oxosteroids in rat brains using LC-electron capture APCI-MS after derivatization with 2-nitro-4-trifluoromethylphenylhydrazine.

  The Analyst 20030201

• 3Beta-sulfamate derivatives of C19 and C21 steroids bearing a t-butylbenzyl or a benzyl group: synthesis and evaluation as non-estrogenic and non-androgenic steroid sulfatase inhibitors.

  Journal of enzyme inhibition and medicinal chemistry 20030201

• Studies on neurosteroids XV. Development of enzyme-linked immunosorbent assay for examining whether pregnenolone sulfate is a veritable neurosteroid.

  Journal of pharmaceutical and biomedical analysis 20030115

• Seasonal changes in neurosteroid concentrations in the amphibian brain and environmental factors regulating their changes.

  Brain research 20030110

• Ovine steroid 17alpha-hydroxylase cytochrome P450: characteristics of the hydroxylase and lyase activities of the adrenal cortex enzyme.

  Archives of biochemistry and biophysics 20030101

• Characterization and regulation of the 3beta-hydroxysteroid dehydrogenase isomerase enzyme in the rat sciatic nerve.

  Journal of neurochemistry 20030101

• Exogenous steroid substrate modifies the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estradiol production of human luteinized granulosa cells in vitro.

  Biology of reproduction 20030101

• Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype.

  The Journal of clinical endocrinology and metabolism 20030101

• Effects of deletion of the prolactin receptor on ovarian gene expression.

  Reproductive biology and endocrinology : RB&E 20030101

• Pregnanolone isomers, pregnenolone and their polar conjugates around parturition.

  Physiological research 20030101

• Molecular cloning and heterologous expression in E. coli of cytochrome P45017alpha. Comparison of structural and functional properties of substrate-specific cytochromes P450 from different species.

  Biochemistry. Biokhimiia 20030101

• Increased neurosteroid sensitivity of hippocampal GABAA receptors during postnatal development.

  Neuroscience 20030101

• Growth hormone and insulin-like growth factor-I action on progesterone secretion by porcine corpora lutea isolated at various periods of the luteal phase.

  Acta veterinaria Hungarica 20030101

• 4-aminopyridine decreases progesterone production by porcine granulosa cells.

  Reproductive biology and endocrinology : RB&E 20030101

• Steroid modulation of angiotensin II action in the rat anterior pituitary gland.

  Neuro endocrinology letters 20030101

• Reliability of follicle-stimulating hormone measurements in serum.

  Reproductive biology and endocrinology : RB&E 20030101

• Paracrine effects of oocyte secreted factors and stem cell factor on porcine granulosa and theca cells in vitro.

  Reproductive biology and endocrinology : RB&E 20030101

• Effects of neurosteroids on epileptiform activity induced by picrotoxin and 4-aminopyridine in the rat hippocampal slice.

  Epilepsy research 20030101

• Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease.

  Neuroscience 20030101

• Cholesterol transport and steroidogenesis by the corpus luteum.

  Reproductive biology and endocrinology : RB&E 20030101

• Effects of S-petasin on corticosterone release in rats.

  The Chinese journal of physiology 20021231

• Androgen biosynthesis from cholesterol to DHEA.

  Molecular and cellular endocrinology 20021230

• Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR).

  The Journal of biological chemistry 20021206

• Inhibition by pregnenolone sulfate of nicotinic acetylcholine response in adrenal chromaffin cells.

  European journal of pharmacology 20021205

• Cryopreserved precision-cut rat liver slices: morphology and cytochrome P450 isoforms expression after prolonged incubation.

  Toxicology in vitro : an international journal published in association with BIBRA 20021201

• 22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide.

  Journal of neurochemistry 20021201

• Endotoxin increases sleep and brain allopregnanolone concentrations in newborn lambs.

  Pediatric research 20021201

• Development of a quantitative assay method for 3 beta-hydroxy-delta 5-steroid dehydrogenase in the rat testis.

  Steroids 20021201

• Seasonal changes in the activity of cytochrome P450(C17) from the testis of Bufo arenarum.

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20021201

• Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species.

  Endocrinology 20021201

• Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency.

  The Journal of clinical endocrinology and metabolism 20021201

• A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-specific caspase-2 activation in the retinal cell death.

  Journal of neurochemistry 20021201

• Corticosterone acutely prolonged N-methyl-d-aspartate receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons.

  Journal of neurochemistry 20021201

• Serum concentrations of delta 5-3 beta-hydroxysteroids in type 2 diabetes mellitus.

  Biological & pharmaceutical bulletin 20021201

• Ovarian modulators of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity in follicular fluid from gonadotrophin-stimulated assisted conception cycles.

  Reproduction (Cambridge, England) 20021201

• Effects of a neurosteroid, pregnenolone, during the neonatal period on adenosine A1 receptor, dopamine metabolites in the fronto-parietal cortex and behavioral response in the open field.

  Brain research 20021129

• Timing of exposure to a pulp and paper effluent influences the manifestation of reproductive effects in rainbow trout.

  Environmental toxicology and chemistry 20021101

• Steroid and sterol 7-hydroxylation: ancient pathways.

  Steroids 20021101

• Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients.

  The Journal of clinical endocrinology and metabolism 20021101

• Baboon cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17).

  European journal of biochemistry 20021101

• A possible alternative to 17beta-estradiol in a viviparous lizard, Tiliqua nigrolutea.

  General and comparative endocrinology 20021101

• Expression of steroidogenic acute regulatory protein in cultured Schwann cells and its regulation by cAMP.

  Annals of the New York Academy of Sciences 20021101

• Identification of two alternate splice variants of a novel serine protease expressed in steroidogenic tissues.

  Endocrine research 20021101

• Temporal effect of tamoxifen on cytochrome P450 side chain cleavage gene expression and steroid concentration in adult male rats.

  The Journal of steroid biochemistry and molecular biology 20021101

• The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells.

  The Journal of biological chemistry 20021018

• Purification and properties of a new Brevibacterium sterolicum cholesterol oxidase produced by E. coli MM294/pnH10.

  FEMS microbiology letters 20021008

• The neurosteroid pregnenolone sulfate infused into the medial septum nucleus increases hippocampal acetylcholine and spatial memory in rats.

  Brain research 20021004

• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.

  Endocrine reviews 20021001

• Sulfonation and molecular action.

  Endocrine reviews 20021001

• Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase.

  The Journal of biological chemistry 20020927

• Androgen biosynthesis in the quail brain.

  Brain research 20020906

• Incidentally detected giant oncocytoma arising in retroperitoneal heterotopic adrenal tissue.

  Archives of pathology & laboratory medicine 20020901

• Detection of oestrogenic activity of steroids present during mammalian gestation using oestrogen receptor alpha- and oestrogen receptor beta-specific in vitro assays.

  The Journal of endocrinology 20020901

• Longitudinal study of plasma pregnenolone and 17-hydroxypregnenolone in full-term and preterm neonates at birth and during the early neonatal period.

  The Journal of clinical endocrinology and metabolism 20020901

• Nitric oxide potently inhibits the rate-limiting enzymatic step in steroidogenesis.

  Molecular and cellular endocrinology 20020830

• Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors.

  The Journal of biological chemistry 20020809

• Inhibition of testosterone production by propylthiouracil in rat Leydig cells.

  Biology of reproduction 20020801

• A genome-wide linkage scan for steroids and SHBG levels in black and white families: the HERITAGE Family Study.

  The Journal of clinical endocrinology and metabolism 20020801

• Compound heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (CYP11A) cause congenital adrenal insufficiency in humans.

  The Journal of clinical endocrinology and metabolism 20020801

• Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression.

  The European journal of neuroscience 20020801

• Pregnenolone metabolites in rat testis: endogenous concentrations, and intracellular distribution in whole testes during incubation in vitro.

  The Journal of steroid biochemistry and molecular biology 20020801

• Inhibition of 3beta-hydroxysteroid dehydrogenase-isomerase in mouse adrenal cells: a direct effect of testosterone.

  Steroids 20020701

• Accumulation of 4- and 5-ene steroid sulfates in human breast cyst fluids.

  The Journal of steroid biochemistry and molecular biology 20020701

• Membrane reconstitution of recombinant guinea pig cytochrome P45017alpha and the effects of site-directed mutagenesis on androgen formation.

  The Journal of steroid biochemistry and molecular biology 20020701

• Low pregnenolone sulphate plasma concentrations in patients with generalized social phobia.

  Psychological medicine 20020701

• Behavioral effects of chronic melatonin and pregnenolone injections in a myelin mutant rat (taiep).

  The Journal of general psychology 20020701

• Neurosteroids enhance bandpass filter characteristics of the rat Schaffer collateral-to-CA1 synapse.

  Neuroscience letters 20020621

• Ectopic expression of MHC class II genes (RT1.B(I) beta/alpha) in rat hepatocytes in vivo and in culture can be elicited by treatment with the pregnane X receptor agonists pregnenolone 16 alpha-carbonitrile and dexamethasone.

  Life sciences 20020607

• SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair.

  The Journal of pharmacology and experimental therapeutics 20020601

• A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia.

  The Journal of clinical endocrinology and metabolism 20020601

• Alteration of substrate specificity of cholesterol oxidase from Streptomyces sp. by site-directed mutagenesis.

  Protein engineering 20020601

• Using biologic markers to identify legitimate chronic pain.

  American clinical laboratory 20020601

• Reproductive hormonal treatments for mood disorders in women.

  Dialogues in clinical neuroscience 20020601

• Gonadal steroids, brain, and behavior: role of context.

  Dialogues in clinical neuroscience 20020601

• Gender differences in steroid modulation of angiotensin II-induced protein kinase C activity in anterior pituitary of the rat.

  Biochemical and biophysical research communications 20020531

• Cellular surface display of dimeric Adx and whole cell P450-mediated steroid synthesis on E. coli.

  Journal of biotechnology 20020523

• 3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501

• Sex- and age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects.

  The Journal of clinical endocrinology and metabolism 20020501

• A neuroactive steroid, pregnenolone, alters the striatal dopaminergic tone before and after puberty.

  Neuroendocrinology 20020501

• GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid.

  Neuropharmacology 20020501

• The cDNA cloning and tissue expression of the cytochrome P450scc from Syrian hamster (Mesocricetus auratus).

  General and comparative endocrinology 20020501

• Thyroid hormone-induced protein (TIP) gene expression by 3,5,3(')-triiodothyronine in the ovarian follicle of perch (Anabas testudineus, Bloch): modulation of 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4)-isomerase enzyme by TIP.

  General and comparative endocrinology 20020501

• Pregnenolone sulfate, dehydroepiandrosterone sulfate and allotetrahydrodeoxycorticosterone affect rapid tolerance to the hypothermic effect of ethanol.

  Brain research bulletin 20020501

• Structural specificity of steroids in stimulating DNA synthesis and protooncogene expression in primary rat hepatocyte cultures.

  The Journal of steroid biochemistry and molecular biology 20020501

• Effects of aging on hypothalamic-pituitary-adrenal system function in non-human primates.

  Mechanisms of ageing and development 20020430

• Concentration dependency in lead-inhibited steroidogenesis in MA-10 mouse Leydig tumor cells.

  Journal of toxicology and environmental health. Part A 20020412

• Novel steroidal vinyl fluorides as inhibitors of steroid C17(20) lyase.

  Bioorganic & medicinal chemistry 20020401

• Modulation of goldfish testicular testosterone production in vitro by tumor necrosis factor alpha, interleukin-1beta, and macrophage conditioned media.

  The Journal of experimental zoology 20020401

• Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.

  Toxicology in vitro : an international journal published in association with BIBRA 20020401

• Expression of nitric oxide synthases in rat adrenal zona fasciculata cells.

  Endocrinology 20020401

• Cytochrome P450 3A conjugation to ubiquitin in a process distinct from classical ubiquitination pathway.

  Molecular pharmacology 20020401

• Transforming growth factor-beta1 inhibits steroidogenesis in human trophoblast cells.

  Molecular human reproduction 20020401

• Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta.

  The Journal of clinical endocrinology and metabolism 20020401

• Two neuroactive steroids in midpregnancy as measured in maternal and fetal sera and in amniotic fluid.

  Steroids 20020401

• Immunohistochemical localization of steroidogenic enzymes and prolactin receptors in the corpus luteum and placenta of spotted seals (Phoca largha) during late pregnancy.

  The Journal of veterinary medical science 20020401

• Requirement for ERK1/2 activation in the regulation of progesterone production in human granulosa-lutein cells is stimulus specific.

  Endocrinology 20020301

• Interdependence of steroidogenesis and shape changes in Y1 adrenocortical cells: studies with inhibitors of phosphoprotein phosphatases.

  The Journal of endocrinology 20020301

• Oxygen-dependence of ACTH-stimulated aldosterone and corticosterone synthesis in the rat adrenal cortex: developmental aspects.

  The Journal of endocrinology 20020301

• Molecular control of luteal secretion of progesterone.

  Reproduction (Cambridge, England) 20020301

• Decreased steroidogenic enzyme 17,20-lyase and increased 17-hydroxylase activities in type 2 diabetes mellitus.

  European journal of endocrinology 20020301

• Changes in GABAA receptor gamma 2 subunit gene expression induced by long-term administration of oral contraceptives in rats.

  Neuropharmacology 20020301

• Effect of clofibrate administration on the esterification and deesterification of steroid hormones by liver and extrahepatic tissues in rats.

  Biochemical pharmacology 20020301

• Stimulatory effects of hyperprolactinemia on aldosterone secretion in ovariectomized rats.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20020301

• Effects of fasting on corticosterone production by zona fasciculata-reticularis cells in ovariectomized rats.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20020301

• Evidence for the biosynthesis of DHEA from cholesterol by first-trimester human placental tissue: source of androgens.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020301

• Alterations in ovarian follicular progesterone secretion by elevated exposures to the drinking water disinfection by-product dibromoacetic acid: examination of the potential site(s) of impact along the steroidogenic pathway.

  Toxicology 20020227

• The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020201

• Expression of 3 beta-hydroxysteroid dehydrogenase in early bovine embryo development.

  Molecular reproduction and development 20020201

• A hydroxysteroid sulfotransferase, st2b2, is a skin cholesterol sulfotransferase in mice.

  Journal of biochemistry 20020201

• The influence of maternal size on placental, fetal and postnatal growth in the horse. II. Endocrinology of pregnancy.

  The Journal of endocrinology 20020201

• Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids.

  British journal of pharmacology 20020201

• Steroid hormone receptors and dietary ligands: a selected review.

  The Proceedings of the Nutrition Society 20020201

• Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.

  The Journal of biological chemistry 20020125

• Thiazolidinediones influence plasma steroids of male obese Zucker rats.

  Endocrinology 20020101

• Structural analysis of oligosaccharides by atmospheric pressure matrix-assisted laser desorption/ionisation quadrupole ion trap mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20020101

• Chronic effects of prepubertal ethanol administration on steroidogenic acute regulatory protein in the rat ovary.

  Alcoholism, clinical and experimental research 20020101

• Assessment of the ability of type 2 cytochrome b5 to modulate 17,20-lyase activity of human P450c17.

  The Journal of steroid biochemistry and molecular biology 20020101

• Comparison of the hamster and human adrenal P450c17 (17 alpha-hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling.

  The Journal of steroid biochemistry and molecular biology 20020101

• Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells.

  Journal of andrology 20020101

• Progesterone attenuates the inhibitory effects of cardiotonic digitalis on pregnenolone production in rat luteal cells.

  Journal of cellular biochemistry 20020101

• [Effect of genotype on hormonal function formation of Leydig cells during mouse postnatal development].

  Ontogenez 20020101

• 3 Beta-hydroxysteroid dehydrogenase expression in rat spinal cord.

  Neuroscience 20020101

• Placentation in the African elephant, Loxodonta africana. I. Endocrinological aspects.

  Reproduction (Cambridge, England) Supplement 20020101

• Histological and metabolism analysis of P450 expression in the brain.

  Methods in enzymology 20020101

• C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-C17, 20-lyase: synthesis and biological evaluation.

  Archiv der Pharmazie 20020101

• Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes.

  Journal of pharmacological and toxicological methods 20020101

• Structure-function relationships of human apolipoprotein D an immunochemical analysis.

  Life sciences 20011228

• Adenosine A2A, 5-HT1A and 5-HT7 receptor in neonatally pregnenolone-treated rats.

  Neuroreport 20011204

• Implications of progesterone metabolism in MA-10 cells for accurate measurement of the rate of steroidogenesis.

  Endocrinology 20011201

• Adrenodoxin-cytochrome P450scc interaction as revealed by EPR spectroscopy: comparison with the putidaredoxin-cytochrome P450cam system.

  Journal of biochemistry 20011201

• Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.

  The Journal of physiology 20011201

• Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein.

  Molecular endocrinology (Baltimore, Md.) 20011201

• Differential involvement of the sigma(1) (sigma(1)) receptor in the anti-amnesic effect of neuroactive steroids, as demonstrated using an in vivo antisense strategy in the mouse.

  British journal of pharmacology 20011201

• Neuroactive ring A-reduced metabolites of progesterone in human plasma during pregnancy: elevated levels of 5 alpha-dihydroprogesterone in depressed patients during the latter half of pregnancy.

  The Journal of clinical endocrinology and metabolism 20011201

• Anti-aging products, Part II. What hormones can and can't do.

  Harvard women's health watch 20011201

• Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats.

  The European journal of neuroscience 20011201

• Identification of ST2A1 as a rat brain neurosteroid sulfotransferase mRNA.

  Brain research 20011130

• Influence of neurosteroids on the development of rapid tolerance to ethanol in mice.

  European journal of pharmacology 20011116

• Automated chromatographic system for the simultaneous measurement of plasma pregnenolone and 17-hydroxypregnenolone by radioimmunoassay.

  Journal of chromatography. B, Biomedical sciences and applications 20011105

• Neuroactive steroids modulate crustacean locomotor activity.

  Neuroscience letters 20011102

• Hormonal steroidogenesis in liver and small intestine of the green frog, Rana esculenta L.

  Life sciences 20011102

• Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads.

  The Journal of endocrinology 20011101

• Influence of membrane cholesterol on modulation of the GABA(A) receptor by neuroactive steroids and other potentiators.

  British journal of pharmacology 20011101

• Anatomical and biochemical evidence for the synthesis of unconjugated and sulfated neurosteroids in amphibians.

  Brain research. Brain research reviews 20011101

• The interaction between neuroactive steroids and the sigma1 receptor function: behavioral consequences and therapeutic opportunities.

  Brain research. Brain research reviews 20011101

• Neurosteroids: recent findings.

  Brain research. Brain research reviews 20011101

• Dehydroepiandrosterone and the relationship with aging and memory: a possible link with protein kinase C functional machinery.

  Brain research. Brain research reviews 20011101

• Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging.

  Brain research. Brain research reviews 20011101

• Derivatization in liquid chromatography/mass spectrometric analysis of neurosteroids.

  Se pu = Chinese journal of chromatography 20011101

• Purification of cytochromes P-450(scc) and P-450(17 alpha) by steroid-binding affinity column chromatography.

  Journal of biochemical and biophysical methods 20011030

• Activity and localization of 3beta-hydroxysteroid dehydrogenase/ Delta5-Delta4-isomerase in the zebrafish central nervous system.

  The Journal of comparative neurology 20011022

• 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.

  Bioorganic & medicinal chemistry 20011001

• Aldosterone increases T-type calcium currents in human adrenocarcinoma (H295R) cells by inducing channel expression.

  Endocrinology 20011001

• Prevention of the stress-induced increase in frontal cortical dopamine efflux of freely moving rats by long-term treatment with antidepressant drugs.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20011001

• Opposite effects of short- versus long-term administration of fluoxetine on the concentrations of neuroactive steroids in rat plasma and brain.

  Psychopharmacology 20011001

• Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20011001

• Acute effects of ethanol on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary.

  Alcoholism, clinical and experimental research 20011001

• The interaction of bovine adrenodoxin with CYP11A1 (cytochrome P450scc) and CYP11B1 (cytochrome P45011beta ). Acceleration of reduction and substrate conversion by site-directed mutagenesis of adrenodoxin.

  The Journal of biological chemistry 20010928

• Pregnenolone sulfate modulates angiotensin II-induced inositol 1,4,5-trisphosphate changes in the anterior pituitary of female rat.

  Biochemical and biophysical research communications 20010928

• Membrane cholesterol modulates serotonin transporter activity.

  Biochemistry 20010904

• Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors.

  Molecular pharmacology 20010901

• Cytochrome P450 in the brain; a review.

  Current drug metabolism 20010901

• Subunit-specific modulation of glycine receptors by neurosteroids.

  Neuropharmacology 20010901

• Pregnenolone sulfate and aging of cognitive functions: behavioral, neurochemical, and morphological investigations.

  Hormones and behavior 20010901

• Analysis of neurosteroid levels in attention deficit hyperactivity disorder.

  The international journal of neuropsychopharmacology 20010901

• Immunohistochemical localization of steroidogenic enzymes in the corpus luteum and the placenta of the ribbon seal (Phoca fasciata) and steller sea lion (Eumetopias jubatus).

  The Journal of veterinary medical science 20010901

• Decreased expression of steroidogenic acute regulatory protein: a novel mechanism participating in the leptin-induced inhibition of glucocorticoid biosynthesis.

  Endocrinology 20010801

• Neurosteroid synthesis by cytochrome p450-containing systems localized in the rat brain hippocampal neurons: N-methyl-D-aspartate and calcium-dependent synthesis.

  Endocrinology 20010801

• Tracking the role of a star in the sky of the new millennium.

  Molecular endocrinology (Baltimore, Md.) 20010801

• Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency.

  The Journal of clinical endocrinology and metabolism 20010801

• Development of an enzyme immunoassay for serum 16-dehydropregnenolone.

  Biological & pharmaceutical bulletin 20010801

• Effects of different steroid-biosynthesis inhibitors on the testicular steroidogenesis of the toad Bufo arenarum.

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20010801

• Effect of treatment of hypothyroidism on the plasma concentrations of neuroactive steroids and homocysteine.

  Clinical chemistry and laboratory medicine 20010801

• Neuroactive steroid-serotonergic interaction: responses to an intravenous L-tryptophan challenge in women with premenstrual syndrome.

  European journal of endocrinology 20010701

• Ontogeny of steroid metabolizing enzymes in rat oligodendrocytes.

  The Journal of steroid biochemistry and molecular biology 20010701

• Cerebral venous thrombosis in a patient of paroxysmal nocturnal haemoglobinuria following aplastic anaemia.

  The Journal of the Association of Physicians of India 20010701

• Leukemia inhibitory factor antagonizes gonadotropin induced-testosterone synthesis in cultured porcine leydig cells: sites of action.

  Endocrinology 20010601

• Creation and activity of COS-1 cells stably expressing the F2 fusion of the human cholesterol side-chain cleavage enzyme system.

  Endocrinology 20010601

• Steroids in the nervous system: a Pandora's box?

  Trends in neurosciences 20010601

• Molecular modelling of 17 alpha-hydroxylase-17,20-lyase.

  Die Pharmazie 20010601

• Aryl hydrocarbon receptor (AhR)-linked inhibition of luteal cell progesterone secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20010601

• Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b).

  The Journal of steroid biochemistry and molecular biology 20010601

• Stimulatory effect of lactate on testosterone production by rat Leydig cells.

  Journal of cellular biochemistry 20010601

• Luteinization factor-stimulated steroidogenesis in porcine granulosa cells.

  General physiology and biophysics 20010601

• Serum concentration of androstenediol and androstenediol sulfate in patients with hyperthyroidism and hypothyroidism.

  Endocrine journal 20010601

• Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics.

  Chemico-biological interactions 20010516

• Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit.

  The Journal of physiology 20010501

• 16alpha,17alpha-Epoxy-20-oxopregn-5-en-3beta-yl acetate.

  Acta crystallographica. Section C, Crystal structure communications 20010501

• [Effect of genotype and social stress on cAMP- and substrate-dependent mechanisms of regulating hormonal function of testis in mice].

  Genetika 20010501

• Expression and localization of cytochrome P450 17 alpha-hydroxylase/c17,20-lyase in the avian brain.

  Brain research 20010427

• Measurement of testosterone and pregnenolone in nails using gas chromatography-mass spectrometry.

  Journal of chromatography. B, Biomedical sciences and applications 20010425

• cyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostate.

  The Biochemical journal 20010415

• Developmental changes in progesterone biosynthesis and metabolism in the quail brain.

  Brain research 20010413

• Regulation of acute cortisol synthesis by cAMP-dependent protein kinase and protein kinase C in a teleost species, the rainbow trout (Oncorhynchus mykiss).

  The Journal of endocrinology 20010401

• Screening for mutations in the steroidogenic acute regulatory protein and steroidogenic factor-1 genes, and in CYP11A and dosage-sensitive sex reversal-adrenal hypoplasia gene on the X chromosome, gene-1 (DAX-1), in hyperandrogenic hirsute women.

  The Journal of clinical endocrinology and metabolism 20010401

• Oxidized adrenodoxin acts as a competitive inhibitor of cytochrome P450scc in mitochondria from the human placenta.

  European journal of biochemistry 20010401

• Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells.

  British journal of pharmacology 20010401

• Neurosteroid-induced enhancement of glutamate transmission in rat hippocampal slices.

  Neuroscience letters 20010330

• Steroidogenic correlates of pregnancy in the rock hyrax (Procavia capensis).

  Life sciences 20010323

• Enhanced dehydroepiandrosterone synthesis by amnion compared to chorion: a comparative study using the reverse-isotope dilution technique.

  Molecular reproduction and development 20010301

• Inhibition of basal and stimulated progesterone synthesis by dichlorodiphenyldichloroethylene and methoxychlor in a stable pig granulosa cell line.

  Reproduction (Cambridge, England) 20010301

• Distinct effect of pregnenolone sulfate on NMDA receptor subtypes.

  Neuropharmacology 20010301

• Follicle-stimulating hormone regulates steroidogenic enzymes in cultured cells of the chick embryo ovary.

  General and comparative endocrinology 20010301

• Progestins block cholesterol synthesis to produce meiosis-activating sterols.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010301

• Troglitazone is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase enzyme in the ovary.

  American journal of obstetrics and gynecology 20010301

• Synthesis of progesterone in Schwann cells: regulation by sensory neurons.

  The European journal of neuroscience 20010301

• Androgens and aging.

  Maturitas 20010227

• The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse.

  Molecular and cellular endocrinology 20010214

• Steroids differentially inhibit the nicotinic acetylcholine receptor.

  Neuroreport 20010212

• A high dose of vitamin E inhibits adrenal corticosterone synthesis in chickens treated with ACTH.

  Journal of nutritional science and vitaminology 20010201

• The inhibitory effects of lead on steroidogenesis in MA-10 mouse Leydig tumor cells.

  Life sciences 20010112

• Allopregnanolone, pregnenolone sulfate, and epitestosterone in breast cyst fluid.

  Steroids 20010101

• Neonatal dexamethasone treatment induces long-lasting changes in T-cell receptor vbeta repertoire in rats.

  Journal of neuroimmunology 20010101

• Effects of hyperprolactinemia on testosterone production in rat Leydig cells.

  Journal of cellular biochemistry 20010101

• Assessment of mechanisms of thyroid hormone action in mouse Leydig cells: regulation of the steroidogenic acute regulatory protein, steroidogenesis, and luteinizing hormone receptor function.

  Endocrinology 20010101

• Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor.

  Endocrinology 20010101

• The octadecaneuropeptide ODN stimulates neurosteroid biosynthesis through activation of central-type benzodiazepine receptors.

  Journal of neurochemistry 20010101

• Bacterially produced apolipoprotein D binds progesterone and arachidonic acid, but not bilirubin or E-3M2H.

  Journal of molecular recognition : JMR 20010101

• Leydig cell aging: steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme.

  Journal of andrology 20010101

• Analysis of large and small samples of biochemical and clinical data.

  Clinical chemistry and laboratory medicine 20010101

• Pregnenolone protects mouse hippocampal (HT-22) cells against glutamate and amyloid beta protein toxicity.

  Neurochemical research 20010101

• Repellent activity of estrogenic compounds toward zoospores of the phytopathogenic fungus Aphanomyces cochlioides.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101

• Mechanism of action of noradrenaline on secretion of progesterone and oxytocin by the bovine corpus luteum in vitro.

  Acta veterinaria Hungarica 20010101

• [Neurosteroids, their role in brain physiology: neurotrophicity, memory, aging...].

  Bulletin de l'Academie nationale de medecine 20010101

• Neuroactive steroid levels in patients with generalized anxiety disorder.

  The Journal of neuropsychiatry and clinical neurosciences 20010101

• Neurosteroids: beginning of the story.

  International review of neurobiology 20010101

• Role of the peripheral-type benzodiazepine receptor in adrenal and brain steroidogenesis.

  International review of neurobiology 20010101

• Neurosteroid 7-hydroxylation products in the brain.

  International review of neurobiology 20010101

• Neurosteroid analysis.

  International review of neurobiology 20010101

• Increased testicular steroid concentrations in patients with idiopathic infertility and normal FSH levels.

  Archives of andrology 20010101

• Differential effects of octylphenol, 17beta-estradiol, endosulfan, or bisphenol A on the steroidogenic competence of cultured adult rat Leydig cells.

  Reproductive toxicology (Elmsford, N.Y.) 20010101

• Progesterone synthesized by Schwann cells during myelin formation regulates neuronal gene expression.

  Molecular biology of the cell 20000701

• The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

  Molecular endocrinology (Baltimore, Md.) 20000101

• Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element.

  Molecular pharmacology 19981201

• SXR, a novel steroid and xenobiotic-sensing nuclear receptor.

  Genes & development 19981015

• Studies on the relationships between 7 alpha-hydroxylation and the ability of 25- and 27-hydroxycholesterol to suppress the activity of HMG-CoA reductase.

  Biochimica et biophysica acta 19970218

• 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).

  The Journal of pharmacology and experimental therapeutics 19920901

• [The effects of o,p'-DDD on human adrenal steroid synthesis].

  Nihon Naibunpi Gakkai zasshi 19840720

• Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis.

  The Biochemical journal 19840415

• Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro.

  European journal of biochemistry 19750616

• Leydig cells.

  Contraception 19750501

• Conversion of 17-alpha-hydroxypregnenolone to dehydroepiandrosterone by adrenal homogenates of immature and adult guinea pigs.

  Steroids 19670101

• The conversion in vivo of 17-alpha-hydroxypregnenolone to dehydroisoandrosterone and other 17-ketosteroids.

  The Journal of biological chemistry 19600201