145108-58-3 | (S)-5-(1-(2,3-Dimethylphenyl)ethyl)-1h-imidazole hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
20mg	98%	in stock	$58.00	$41.00
100mg	98%	in stock	$221.00	$155.00
250mg	98%	in stock	$512.00	$358.00
1g	98%	in stock	$1,488.00	$1,042.00

Description

• Catalog Number: AA73127
• Chemical Name: (S)-5-(1-(2,3-Dimethylphenyl)ethyl)-1h-imidazole hydrochloride
• CAS Number: 145108-58-3
• Molecular Formula: C13H17ClN2
• Molecular Weight: 236.7405
• MDL Number: MFCD07772269
• SMILES: Cc1cccc(c1C)[C@@H](c1cnc[nH]1)C.Cl

Computed Properties

• Complexity: 205
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2

Literature

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  Critical care medicine 20140701

• Vasovagal syncope and severe bradycardia following intranasal dexmedetomidine for pediatric procedural sedation.

  Paediatric anaesthesia 20140401

• Neurotoxic effects of dexmedetomidine in fetal cynomolgus monkey brains.

  The Journal of toxicological sciences 20140401

• Dexmedetomidine premedication attenuates concanavalin A-induced hepatitis in mice.

  The Journal of toxicological sciences 20140101

• Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough.

  Irish journal of medical science 20121201

• Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine in healthy Korean subjects.

  Journal of clinical pharmacy and therapeutics 20121201

• Evaluation of a ketamine-propofol drug combination with or without dexmedetomidine for intravenous anesthesia in cats undergoing ovariectomy.

  Journal of the American Veterinary Medical Association 20121115

• Dexmedetomidine in the emergency department: assessing safety and effectiveness in difficult-to-sedate acute behavioural disturbance.

  Emergency medicine journal : EMJ 20121101

• Protective effect of dexmedetomidine in a rat model of α-naphthylthiourea-induced acute lung injury.

  The Journal of surgical research 20121101

• Opioid-free perioperative analgesia for hemicolectomy in a patient with opioid-induced delirium: a case report and review of the analgesic efficacy of the alpha-2 agonist agents.

  Pain practice : the official journal of World Institute of Pain 20121101

• The effects of dexmedetomidine on mesenteric arterial occlusion-associated gut ischemia and reperfusion-induced gut and kidney injury in rabbits.

  The Journal of surgical research 20121101

• Intramuscular dexmedetomidine: an effective route of sedation preserves background activity for pediatric electroencephalograms.

  The Journal of pediatrics 20121101

• Dexmedetomidine for sedation in the parturient with respiratory failure requiring noninvasive ventilation.

  Respiratory care 20121101

• Attenuation of spinal cord ischemia-reperfusion injury by specific α-2a receptor activation with dexmedetomidine.

  Journal of vascular surgery 20121101

• A randomised comparison of two intranasal dexmedetomidine doses for premedication in children.

  Anaesthesia 20121101

• Dexmedetomidine to treat lisdexamfetamine overdose and serotonin toxidrome in a 6-year-old girl.

  American journal of critical care : an official publication, American Association of Critical-Care Nurses 20121101

• Dexmedetomidine decreases hyperalgesia in neuropathic pain by increasing acetylcholine in the spinal cord.

  Neuroscience letters 20121031

• Hemodynamic effects of dexmedetomidine in critically ill neonates and infants with heart disease.

  Pediatric cardiology 20121001

• Effects of sedation on echocardiographic variables of left atrial and left ventricular function in healthy cats.

  Journal of feline medicine and surgery 20121001

• Posterior tibial nerve sensory blockade duration prolonged by adding dexmedetomidine to ropivacaine.

  Anesthesia and analgesia 20121001

• Maternal and preterm fetal sheep responses to dexmedetomidine.

  International journal of obstetric anesthesia 20121001

• Use of dexmedetomidine to prevent pulmonary injury after pneumoperitoneum in ventilated rats.

  Surgical laparoscopy, endoscopy & percutaneous techniques 20121001

• Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia.

  Paediatric anaesthesia 20120901

• Effects of dexmedetomidine on conditioned pain modulation in humans.

  European journal of pain (London, England) 20120901

• Effects of propofol and dexmedetomidine on motor coordination and analgesia: a comparative analysis.

  International journal of clinical pharmacology and therapeutics 20120901

• Dexmedetomidine for transport of a spontaneously breathing combative child.

  Pediatrics 20120901

• Hemodynamic effects in dogs after intramuscular administration of a combination of dexmedetomidine-butorphanol-tiletamine-zolazepam or dexmedetomidine-butorphanol-ketamine.

  American journal of veterinary research 20120901

• Preventive effect of dexmedetomidine in ischemia-reperfusion injury.

  The Journal of craniofacial surgery 20120901

• Treatment of delirium following cardiac surgery.

  Journal of cardiac surgery 20120901

• Pharmacologic prevention and treatment of delirium in critically ill and non-critically ill hospitalised patients: a review of data from prospective, randomised studies.

  Best practice & research. Clinical anaesthesiology 20120901

• Plasma glucose, insulin, free fatty acids, lactate and cortisol concentrations in dexmedetomidine-sedated dogs with or without MK-467: a peripheral α-2 adrenoceptor antagonist.

  Veterinary journal (London, England : 1997) 20120801

• The effect of dexmedetomidine on arterial-cardiac baroreflex function assessed by spectral and transfer function analysis.

  Journal of anesthesia 20120801

• The application of dexmedetomidine in children undergoing vitreoretinal surgery.

  Journal of anesthesia 20120801

• Heart rate variability dynamics during low-dose propofol and dexmedetomidine anesthesia.

  Annals of biomedical engineering 20120801

• Use of dexmedetomidine for the treatment of alcohol withdrawal syndrome in critically ill patients: a retrospective case series.

  Journal of anesthesia 20120801

• Superficial temporal artery-middle cerebral artery bypass using local anesthesia and a sedative without endotracheal general anesthesia.

  Journal of neurosurgery 20120801

• Dexmedetomidine dose dependently decreases oral tissue blood flow during sevoflurane and propofol anesthesia in rabbits.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20120801

• Dexmedetomidine: a guide to its use for sedation in the US.

  Clinical drug investigation 20120801

• [Successful anesthetic management in a patient with chronic obstructive pulmonary disease (COPD) using dexmedetomidine and combined spinal-epidural anesthesia for low anterior resection of the rectum].

  Masui. The Japanese journal of anesthesiology 20120801

• Dexmedetomidine and ketamine: an effective alternative for procedural sedation?

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20120701

• Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood.

  Paediatric anaesthesia 20120701

• The influence of a continuous rate infusion of dexmedetomidine on the nociceptive withdrawal reflex and temporal summation during isoflurane anaesthesia in dogs.

  Veterinary anaesthesia and analgesia 20120701

• Dexmedetomidine prevents alterations of intestinal microcirculation that are induced by surgical stress and pain in a novel rat model.

  Anesthesia and analgesia 20120701

• Isoflurane but not halothane minimum alveolar concentration-sparing response of dexmedetomidine is enhanced in rats chronically treated with selective α2-adrenoceptor agonist.

  Laboratory animals 20120701

• Dexmedetomidine reduces emergence agitation after tonsillectomy in children by sevoflurane anesthesia: a case-control study.

  International journal of pediatric otorhinolaryngology 20120701

• Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs.

  Shock (Augusta, Ga.) 20120701

• Effect of dexmedetomidine on brain edema and neurological outcomes in surgical brain injury in rats.

  Anesthesia and analgesia 20120701

• Efficacy of dexmedetomidine in suppressing cardiovascular and hormonal responses to general anaesthesia for caesarean delivery: a dose-response study.

  International journal of obstetric anesthesia 20120701

• Medications for sedation in patients with prolonged mechanical ventilation.

  JAMA 20120627

• CYP2A6 genetic variation and dexmedetomidine disposition.

  European journal of clinical pharmacology 20120601

• Is the addition of dexmedetomidine to a ketamine-propofol combination in pediatric cardiac catheterization sedation useful?

  Pediatric cardiology 20120601

• Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice.

  Journal of anesthesia 20120601

• Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.

  Anesthesiology 20120601

• Dexmedetomidine infusion for sedation in the intensive care setting in an infant with airway compromise due to congenital mediastinal neuroblastoma.

  Paediatric anaesthesia 20120601

• Comparison of effects of dexmedetomidine-ketamine and dexmedetomidine-midazolam combinations in transurethral procedures.

  Urology 20120601

• [Effect of dexmedetomidine on stress responses during extubation in patients undergoing uvulopalatopharyngoplasty].

  Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20120601

• [Dexmedetomidine for sedation of post liver transplantation patients].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20120601

• Dexmedetomidine administration before, but not after, ischemia attenuates intestinal injury induced by intestinal ischemia-reperfusion in rats.

  Anesthesiology 20120501

• Effect of medetomidine-butorphanol and dexmedetomidine-butorphanol combinations on intraocular pressure in healthy dogs.

  Veterinary anaesthesia and analgesia 20120501

• The efficacy of continuous infusion of low dose dexmedetomidine for postoperative patients recovering in general wards.

  European journal of anaesthesiology 20120501

• Hemodynamic impact of dexmedetomidine administration in 15,656 noncardiac surgical cases.

  Journal of clinical anesthesia 20120501

• Effects of isoflurane anesthesia with and without dexmedetomidine or remifentanil on quantitative electroencephalographic variables before and after nociceptive stimulation in dogs.

  American journal of veterinary research 20120501

• [Evaluation of the sedative effect of dexmedetomidine on patients after surgical occlusion of ruptured cerebral aneurysm in intensive care unit].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20120501

• [Dexmedetomidine is an excellent sedative for voice monitoring surgery].

  Masui. The Japanese journal of anesthesiology 20120501

• Questions about dexmedetomidine as a preanesthetic in cats.

  Journal of the American Veterinary Medical Association 20120415

• [Effect of dexmedetomidine on postoperative analgesia and sedation in pediatric patients undergoing cleft lip and palate repair].

  Zhonghua yi xue za zhi 20120403

• Effect of dexmedetomidine on the minimum alveolar concentration of isoflurane in cats.

  Journal of veterinary pharmacology and therapeutics 20120401

• Intravenous dexmedetomidine for treatment of intraoperative penile erection.

  International urology and nephrology 20120401

• Comparison of the effects of fentanyl, remifentanil, and dexmedetomidine on neuromuscular blockade.

  Journal of anesthesia 20120401

• Comparison between propofol and dexmedetomidine in postoperative sedation after extensive cervical spine surgery.

  Journal of anesthesia 20120401

• A high dose of dexmedetomidine using the BIS monitor™ for diagnostic and interventional cardiac catheterization in a toddler with congenital heart disease.

  Journal of anesthesia 20120401

• Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart.

  Biochimica et biophysica acta 20120401

• Weaning from mechanical ventilation and sedation.

  Current opinion in anaesthesiology 20120401

• Stability of dexmedetomidine 4 μg/mL in polypropylene syringes.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120401

• Dose-response and mechanism of protective functions of selective alpha-2 agonist dexmedetomidine on acute lung injury in rats.

  Saudi medical journal 20120401

• [Dexmedetomidine for postoperative sedation in elderly patients with cognitive impairment].

  Masui. The Japanese journal of anesthesiology 20120401

• Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.

  JAMA 20120321

• Weighing the costs and benefits of a sedative.

  JAMA 20120321

• Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl-d-aspartate receptor 2B subunit.

  Brain research bulletin 20120310

• Effects of intravenous administration of dexmedetomidine on intraocular pressure and pupil size in clinically normal dogs.

  Veterinary ophthalmology 20120301

• Influence of MK-467, a peripherally acting α2-adrenoceptor antagonist on the disposition of intravenous dexmedetomidine in dogs.

  Drug metabolism and disposition: the biological fate of chemicals 20120301

• Randomized double-blind study of remifentanil and dexmedetomidine for flexible bronchoscopy.

  British journal of anaesthesia 20120301

• Effects of intravenous dexmedetomidine on low-dose bupivacaine spinal anaesthesia in elderly patients.

  Acta anaesthesiologica Scandinavica 20120301

• Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients.

  British journal of anaesthesia 20120301

• Dexmedetomidine reduces the incidence of fentanyl-induced cough: a double-blind, randomized, and placebo-controlled study.

  Upsala journal of medical sciences 20120301

• Sedative, cardiovascular, haematologic and biochemical effects of four different drug combinations administered intramuscularly in cats.

  Veterinary anaesthesia and analgesia 20120301

• Dexmedetomidine sedation: uses in pediatric procedural sedation outside the operating room.

  Pediatric emergency care 20120301

• Dexmedetomidine for the treatment of severe postoperative functional stridor.

  Anaesthesia and intensive care 20120301

• Comparison of the effectiveness of dexmedetomidine versus propofol target-controlled infusion for sedation during coblation-assisted upper airway procedure.

  Chinese medical journal 20120301

• The relationship between dexmedetomidine dosing and hypotension.

  The journal of trauma and acute care surgery 20120301

• Is dexmedetomidine the agent of choice in the resection of pheochromocytoma?

  The American surgeon 20120301

• Dexmedetomidine compare with fentanyl for postoperative analgesia in outpatient gynecologic laparoscopy: a randomized controlled trial.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20120301

• [Clonidine and dexmedetomidine's effect on the altered expressions of growth associated protein-43 mRNA in rat dorsal root ganglion during the development of chronic neuropathic pain].

  Zhonghua yi xue za zhi 20120221

• Clinical efficacy and safety of dexmedetomidine used as a preanesthetic prior to general anesthesia in cats.

  Journal of the American Veterinary Medical Association 20120215

• Dexmedetomidine directly inhibits vascular ATP-sensitive potassium channels.

  Life sciences 20120213

• Weaning from mechanical ventilation.

  Current opinion in anaesthesiology 20120201

• Discontinuation of prolonged infusions of dexmedetomidine in critically ill children with heart disease.

  Intensive care medicine 20120201

• Pediatric sedation in a community hospital-based outpatient MRI center.

  AJR. American journal of roentgenology 20120201

• [Sedation concepts in intensive care].

  Deutsche medizinische Wochenschrift (1946) 20120201

• Pharmacokinetics of dexmedetomidine administered intravenously in isoflurane-anesthetized cats.

  American journal of veterinary research 20120201

• Use of dexmedetomidine and ketamine in combination with opioids.

  Journal of the American Veterinary Medical Association 20120201

• Use of dexmedetomidine and ketamine in combination with opioids.

  Journal of the American Veterinary Medical Association 20120201

• Occurrence and predictors of dexmedetomidine infusion intolerance and failure.

  Hospital practice (1995) 20120201

• Dexmedetomidine and clonidine induce long-lasting activation of the respiratory rhythm generator of neonatal mice: possible implication for critical care.

  Respiratory physiology & neurobiology 20120115

• Inhibition by dexmedetomidine of the activation of spinal dorsal horn glias and the intracellular ERK signaling pathway induced by nerve injury.

  Brain research 20120103

• Dexmedetomidine and clonidine: from second- to first-line sedative agents in the critical care setting?

  Journal of intensive care medicine 20120101

• Cardiovascular effects of dexmedetomidine sedation in children.

  Anesthesia and analgesia 20120101

• Suspected opioid-induced hyperalgesia in an infant.

  British journal of anaesthesia 20120101

• Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells.

  The Journal of pharmacy and pharmacology 20120101

• Influence of a constant rate infusion of dexmedetomidine on cardiopulmonary function and recovery quality in isoflurane anaesthetized horses.

  Veterinary anaesthesia and analgesia 20120101

• Comparison of the effects of ketamine-dexmedetomidine and sevoflurane-sufentanil anesthesia on cardiac biomarkers after cardiac surgery: an observational study.

  Physiological research 20120101

• The effects of dexmedetomidine on attenuation of stress response to endotracheal intubation in patients undergoing elective off-pump coronary artery bypass grafting.

  Annals of cardiac anaesthesia 20120101

• Dexmedetomidine: current role in anesthesia and intensive care.

  Revista brasileira de anestesiologia 20120101

• Pharmacological and nonpharmacological management of delirium in critically ill patients.

  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20120101

• Prevention, recognition, and management of delirium in the intensive care unit.

  AACN advanced critical care 20120101

• Comparison of sedative drugs under peribulbar or topical anesthesia during phacoemulsification.

  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20120101

• Does vitamin C prevent the effects of high dose dexmedetomidine on rat erythrocyte deformability?

  Bratislavske lekarske listy 20120101

• Cigarette smoking and the effect of dexmedetomidine and fentanyl on tracheal intubation.

  Revista brasileira de anestesiologia 20120101

• A review of pharmacologic management and prevention strategies for delirium in the intensive care unit.

  Psychosomatics 20120101

• Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury.

  BMC neurology 20120101

• The effects of low-high doses of dexmedetomidine on erythrocyte deformability in rats.

  Bratislavske lekarske listy 20120101

• Dexmedetomidine in pediatric cardiac anesthesia.

  Annals of cardiac anaesthesia 20120101

• Dexmedetomidine controls junctional ectopic tachycardia during Tetralogy of Fallot repair in an infant.

  Annals of cardiac anaesthesia 20120101

• Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome.

  Circulation journal : official journal of the Japanese Circulation Society 20120101

• Dexmedetomidine and its increasing application in nonopioid detoxification.

  Journal of opioid management 20120101

• Transcatheter aortic valve replacement under monitored anesthesia care versus general anesthesia with intubation.

  Cardiovascular revascularization medicine : including molecular interventions 20120101

• A comparison of dexmedetomidine sedation with and without midazolam for dental implant surgery.

  Anesthesia progress 20120101

• Efficacy of intrathecally administered dexmedetomidine versus dexmedetomidine with fentanyl in patients undergoing major abdominal cancer surgery.

  Pain physician 20120101

• Dexmedetomidine versus midazolam for conscious sedation in postoperative patients undergoing flexible bronchoscopy: a randomized study.

  The Journal of international medical research 20120101

• Dexmedetomidine versus midazolam for the sedation of patients with non-invasive ventilation failure.

  Internal medicine (Tokyo, Japan) 20120101

• Correlation between bispectral index, observational sedation scale, and lower esophageal sphincter pressure in volunteers using dexmedetomidine or propofol.

  Medical science monitor : international medical journal of experimental and clinical research 20120101

• Neurophysiological assessment of the sedative and analgesic effects of a constant rate infusion of dexmedetomidine in the dog.

  Veterinary journal (London, England : 1997) 20111201

• Dexmedetomidine can stabilize hemodynamics and spare anesthetics before cardiopulmonary bypass.

  Journal of anesthesia 20111201

• Dexmedetomidine: applications for the pediatric patient with congenital heart disease.

  Pediatric cardiology 20111201

• Perioperative infusion of dexmedetomidine at a high dose reduces postoperative analgesic requirements: a randomized control trial.

  Journal of anesthesia 20111201

• Consciousness lost and found: subjective experiences in an unresponsive state.

  Brain and cognition 20111201

• Apparent dexmedetomidine-induced polyuric syndrome in an achondroplastic patient undergoing posterior spinal fusion.

  Anesthesia and analgesia 20111201

• Use of dexmedetomidine to discontinue high-dose fentanyl.

  The Annals of pharmacotherapy 20111201

• Consciousness versus responsiveness: insights from general anesthetics.

  Brain and cognition 20111201

• Evaluation of dexmedetomidine and ketamine in combination with various opioids as injectable anesthetic combinations for castration in cats.

  Journal of the American Veterinary Medical Association 20111201

• Dexmedetomidine controls twitch-convulsive syndrome in the course of uremic encephalopathy.

  Journal of clinical anesthesia 20111201

• Incidence of cardiac arrest increases with the indiscriminate use of dexmedetomidine: a case series and review of published case reports.

  Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20111201

• Bronchial thermoplasty: a novel treatment for severe asthma requiring monitored anesthesia care.

  AANA journal 20111201

• Inhibitory effect of glutamate release from rat cerebrocortical nerve terminals by α2 adrenoceptor agonist dexmedetomidine.

  European journal of pharmacology 20111116

• Evaluation of dexmedetomidine: safety and clinical outcomes in critically ill trauma patients.

  The Journal of trauma 20111101

• The effect of dexmedetomidine during myringotomy and pressure-equalizing tube placement in children.

  Paediatric anaesthesia 20111101

• Children with anterior mediastinal mass: procedural sedation with dexmedetomidine.

  European journal of anaesthesiology 20111101

• Review article: Dexmedetomidine in children: current knowledge and future applications.

  Anesthesia and analgesia 20111101

• Postoperative respiratory and analgesic effects of dexmedetomidine or morphine for adenotonsillectomy in children with obstructive sleep apnoea.

  Anaesthesia 20111101

• Impact of intraoperative dexmedetomidine on postoperative analgesia following gynecologic surgery.

  Current medical research and opinion 20111101

• Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats.

  Upsala journal of medical sciences 20111101

• Hemodynamic effects of dexmedetomidine in isoflurane-anesthetized cats.

  Veterinary anaesthesia and analgesia 20111101

• Regional anesthesia in anticoagulated patients.

  Journal of clinical anesthesia 20111101

• Postpartum analgesia with dexmedetomidine in opioid tolerance during pregnancy.

  Journal of clinical anesthesia 20111101

• Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice.

  Acta anaesthesiologica Scandinavica 20111101

• [Clinical observation of injection of dexmedetomidine in anaesthesia for esophageal cancer operation].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20111101

• Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current.

  Anesthesiology 20111001

• Epidural anesthesia with intravenous dexmedetomidine sedation in the successful anesthetic management of MRI-guided focused ultrasound ablation of early prostatic cancer.

  Journal of anesthesia 20111001

• Wide inter-individual variability of bispectral index and spectral entropy at loss of consciousness during increasing concentrations of dexmedetomidine, propofol, and sevoflurane.

  British journal of anaesthesia 20111001

• A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic study.

  Journal of pharmacokinetics and pharmacodynamics 20111001

• Interaction between dexmedetomidine and α-adrenergic receptors: emphasis on vascular actions.

  Journal of cardiothoracic and vascular anesthesia 20111001

• Postoperative delirium. part 2: detection, prevention and treatment.

  European journal of anaesthesiology 20111001

• Prospective, randomized study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anaesthesia.

  Middle East journal of anaesthesiology 20111001

• Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia.

  British journal of anaesthesia 20110901

• Dexmedetomidine for co-analgesia in chemotherapy-induced severe enterocolitis.

  Paediatric anaesthesia 20110901

• Effects of different doses of L-659'066 on the bispectral index and clinical sedation in dogs treated with dexmedetomidine.

  Veterinary anaesthesia and analgesia 20110901

• Sedation and anesthesia issues in pediatric imaging.

  Pediatric radiology 20110901

• Intramuscular dexmedetomidine sedation for pediatric MRI and CT.

  AJR. American journal of roentgenology 20110901

• Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations.

  The Annals of thoracic surgery 20110901

• [Comparison of sedative effect of dexmedetomidine and midazolam for post-operative patients undergoing mechanical ventilation in surgical intensive care unit].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20110901

• Evaluation of outcomes in patients given dexmedetomidine in functional endoscopic sinus surgery.

  The Annals of otology, rhinology, and laryngology 20110901

• Dexmedetomidine controls agitation and facilitates reliable, serial neurological examinations in a non-intubated patient with traumatic brain injury.

  Neurocritical care 20110801

• The effects of increasing doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs.

  Journal of veterinary pharmacology and therapeutics 20110801

• Effects of different doses of remifentanil infusion on hemodynamics and recovery in children undergoing pediatric diagnostic cardiac catheterization.

  Journal of cardiothoracic and vascular anesthesia 20110801

• Bioavailability of dexmedetomidine after intranasal administration.

  European journal of clinical pharmacology 20110801

• Multicenter assessment of the Iowa Satisfaction with Anesthesia Scale, an instrument that measures patient satisfaction with monitored anesthesia care.

  Anesthesia and analgesia 20110801

• Dexmedetomidine as sole agent for awake fiberoptic intubation in a patient with local anesthetic allergy.

  Journal of anesthesia 20110801

• The effects of dexmedetomidine on regional cerebral blood flow and oxygen consumption during severe hemorrhagic hypotension in rats.

  Anesthesia and analgesia 20110801

• Administration of dexmedetomidine alone during diagnostic cardiac catheterization in adults with congenital heart disease: two case reports.

  Journal of anesthesia 20110801

• Dexmedetomidine and clonidine inhibit the function of Na(v)1.7 independent of α(2)-adrenoceptor in adrenal chromaffin cells.

  Journal of anesthesia 20110801

• [Postoperative analgesia of continuous intravenous fentanyl or dexmedetomidine for patients receiving anticoagulant therapy].

  Masui. The Japanese journal of anesthesiology 20110801

• Dexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation.

  Drugs 20110730

• [Application of sedation with a low dose of dexmedetomidine during intrathecal anesthesia in elderly patients].

  Zhonghua yi xue za zhi 20110726

• Takotsubo cardiomyopathy and the difficult airway.

  Journal of neurosurgical anesthesiology 20110701

• Limb-specific differences in the skin vascular responsiveness to adrenergic agonists.

  Journal of applied physiology (Bethesda, Md. : 1985) 20110701

• Pediatric sedation--evolution and revolution.

  Paediatric anaesthesia 20110701

• A randomized, blinded, controlled trial of the antiemetic effect of ondansetron on dexmedetomidine-induced emesis in cats.

  Veterinary anaesthesia and analgesia 20110701

• Dexmedetomidine for opioid and benzodiazepine withdrawal in pediatric patients.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110701

• Evaluation of the sedative and cardiovascular effects of intramuscular administration of dexmedetomidine with and without concurrent atropine administration in dogs.

  Journal of the American Veterinary Medical Association 20110701

• Dexmedetomidine for the prevention of shivering during spinal anesthesia.

  Clinics (Sao Paulo, Brazil) 20110701

• Effect of a dexmedetomidine substitution during a nationwide propofol shortage in patients undergoing coronary artery bypass graft surgery.

  Pharmacotherapy 20110701

• Sedation for radiological imaging.

  Archives of disease in childhood. Education and practice edition 20110601

• The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery.

  Molecular biology reports 20110601

• Review article: dexmedetomidine: does it have potential in palliative medicine?

  The American journal of hospice & palliative care 20110601

• Prevention of shivering during therapeutic temperature modulation: the Columbia anti-shivering protocol.

  Neurocritical care 20110601

• Evaluation of the analgesic efficacy of local dexmedetomidine application.

  The Clinical journal of pain 20110601

• Delirium and sedation in the ICU.

  Neurocritical care 20110601

• Analgosedation in neonates: do we still need additional tools after 30 years of clinical research?

  Archives of disease in childhood. Education and practice edition 20110601

• Dexmedetomidine sedation for awake fiberoptic intubation of patients with difficult airways due to severe odontogenic cervicofacial infections.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20110601

• Dexmedetomidine: an alternative for epidural anesthesia in tension-free vaginal-tape surgery.

  Journal of anesthesia 20110601

• Volatile agents for ICU sedation?

  Intensive care medicine 20110601

• High-dose dexmedetomidine increases the opioid-free interval and decreases opioid requirement after tonsillectomy in children.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110601

• Dexmedetomidine and S(+)-ketamine in ischemia and reperfusion injury in the rat kidney.

  Acta cirurgica brasileira 20110601

• High-dose dexmedetomidine for sedation in the intensive care unit: an evaluation of clinical efficacy and safety.

  The Annals of pharmacotherapy 20110601

• Dexmedetomidine as a pediatric anesthetic premedication to reduce anxiety and to deter emergence delirium.

  AANA journal 20110601

• Dexmedetomidine (Precedex) for ICU sedation.

  The Medical letter on drugs and therapeutics 20110530

• Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia rats.

  The Journal of surgical research 20110515

• Modulation of postjunctional α-adrenergic vasoconstriction during exercise and exogenous ATP infusions in ageing humans.

  The Journal of physiology 20110515

• Hemodynamics in coronary artery bypass surgery: effects of intraoperative dexmedetomidine administration.

  Der Anaesthesist 20110501

• c-Jun NH₂-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle.

  Yonsei medical journal 20110501

• Role of α2-agonists in the treatment of acute alcohol withdrawal.

  The Annals of pharmacotherapy 20110501

• Evaluation of dexmedetomidine and ketamine in combination with opioids as injectable anesthesia for castration in dogs.

  Journal of the American Veterinary Medical Association 20110501

• Hemodynamic characteristics of midazolam, propofol, and dexmedetomidine in healthy volunteers.

  Journal of clinical anesthesia 20110501

• Dexmedetomidine and procedural sedation: the AusPAR a TGA resource.

  Anaesthesia and intensive care 20110501

• The effects of intraoperative infusion of dexmedetomidine on early renal function after percutaneous nephrolithotomy.

  Acta anaesthesiologica Scandinavica 20110501

• Dexmedetomidine protects blood δ-aminolevulinate dehydratase from inactivation caused by hyperoxygenation in total intravenous anesthesia.

  Human & experimental toxicology 20110401

• A randomized, controlled trial on dexmedetomidine for providing adequate sedation and hemodynamic control for awake, diagnostic transesophageal echocardiography.

  Journal of cardiothoracic and vascular anesthesia 20110401

• Post-operative dexmedetomidine-based sedation after uneventful intracranial surgery for unruptured cerebral aneurysm: comparison with propofol-based sedation.

  Neurocritical care 20110401

• Effects of dexmedetomidine on the release of glial cell line-derived neurotrophic factor from rat astrocyte cells.

  Neurochemistry international 20110401

• Successful implementation of a pediatric sedation protocol for mechanically ventilated patients.

  Critical care medicine 20110401

• Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers.

  British journal of anaesthesia 20110401

• Impact of dexmedetomidine on early extubation in pediatric cardiac surgical patients.

  Intensive care medicine 20110401

• Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine.

  Circulation. Cardiovascular genetics 20110401

• Oral melatonin, dexmedetomidine, and midazolam for prevention of postoperative agitation in children.

  Journal of anesthesia 20110401

• The comparison of the effects of dexmedetomidine and midazolam sedation on electroencephalography in pediatric patients with febrile convulsion.

  Paediatric anaesthesia 20110401

• Sedation with dexmedetomidine hydrochloride during endoscopic submucosal dissection of gastric cancer.

  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 20110401

• When the decision is what to decide: using evidence inventory reports to focus health technology assessments.

  International journal of technology assessment in health care 20110401

• [Effect of dexmedetomidine on patient-controlled intravenous analgesia with fentanyl in elderly patients after total hip replacement].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110401

• [Measurement of the minimum alveolar concentration of sevoflurane during combined anesthesia with sevoflurane, small-dose dexmedetomidine and fentanyl].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110401

• [Determination of the 50% effective concentration of dexmedetomidine as an adjuvant in combined spinal-epidural anesthesia with Narcotrend].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110401

• [The effect of dexmedetomidine in a child with intractable supraventricular tachyarrythmia after total cavopulmonary connection].

  Masui. The Japanese journal of anesthesiology 20110401

• Dexmedetomidine in cardiac surgery patients who fail extubation and present with a delirium state.

  The heart surgery forum 20110401

• Use of dexmedetomidine and ketamine infusions during scoliosis repair surgery with somatosensory and motor-evoked potential monitoring: a case report.

  AANA journal 20110401

• Efficacy and safety of dexmedetomidine versus morphine in post-operative cardiac surgery patients.

  International journal of clinical pharmacy 20110401

• Dexmedetomidine as an adjuvant analgesic for intractable cancer pain.

  Journal of palliative medicine 20110301

• Pharmacokinetics of dexmedetomidine in Chinese post-surgical intensive care unit patients.

  Acta anaesthesiologica Scandinavica 20110301

• Evaluation of medetomidine-ketamine and dexmedetomidine-ketamine in Chinese water deer (Hydropotes inermis).

  Veterinary anaesthesia and analgesia 20110301

• Dorsal hand vein responses to the α₁-adrenoceptor agonist phenylephrine do not predict responses to the α₂-adrenoceptor agonist dexmedetomidine.

  European journal of pharmacology 20110225

• Independent regulation of α1 and α2 adrenergic receptor-mediated vasoconstriction in vivo.

  Journal of hypertension 20110201

• High-dose dexmedetomidine sedation for pediatric MRI.

  Paediatric anaesthesia 20110201

• Pediatric CT sedation: comparison of dexmedetomidine and pentobarbital.

  AJR. American journal of roentgenology 20110201

• Dexmedetomidine use in pediatric airway reconstruction.

  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20110201

• Prospective, randomized controlled study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anesthesia.

  Middle East journal of anaesthesiology 20110201

• Dexmedetomidine premedication of outpatients under IVRA.

  Middle East journal of anaesthesiology 20110201

• Dexmedetomidine controls the hemodynamic manifestations of tourniquet pain.

  American journal of therapeutics 20110101

• Dexmedetomidine: pediatric pharmacology, clinical uses and safety.

  Expert opinion on drug safety 20110101

• Dexmedetomidine: new insights.

  European journal of anaesthesiology 20110101

• Dexmedetomidine-related atrial standstill and loss of capture in a pediatric patient after congenital heart surgery.

  Critical care medicine 20110101

• Use of dexmedetomidine for sedation in critically ill mechanically ventilated pediatric burn patients.

  Journal of burn care & research : official publication of the American Burn Association 20110101

• Angiotensin-converting enzyme inhibitor - An innocuous factor behind cardiac arrest following induction of anesthesia.

  Annals of cardiac anaesthesia 20110101

• Two doses of dexmedetomidine in combination with buprenorphine for premedication in dogs; a comparison with acepromazine and buprenorphine.

  Veterinary anaesthesia and analgesia 20110101

• [Dexmedetomidine for endoscopic submucosal dissection in a patient with severe chronic obstructive pulmonary disease].

  Masui. The Japanese journal of anesthesiology 20110101

• Dexmedetomidine and procedural sedation.

  Anaesthesia and intensive care 20110101

• Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats.

  Pharmacological reports : PR 20110101

• Anesthetic management for combined mitral valve replacement and aortic valve repair in a patient with osteogenesis imperfecta.

  Annals of cardiac anaesthesia 20110101

• Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice.

  Critical care (London, England) 20110101

• Dexmedetomidine use during strabismus surgery in agitated children.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20110101

• Integrative review utilizing dexmedetomidine as an anesthetic for monitored anesthesia care and regional anesthesia.

  Nursing forum 20110101

• Ephedrine enhances the antinociceptive effect of dexmedetomidine in mice.

  Neuro endocrinology letters 20110101

• Additives to local anesthetics for peripheral nerve blockade.

  International anesthesiology clinics 20110101

• Pharmacokinetics of prolonged infusion of high-dose dexmedetomidine in critically ill patients.

  Critical care (London, England) 20110101

• Comparison of an intraoperative infusion of dexmedetomidine or remifentanil on perioperative haemodynamics, hypnosis and sedation, and postoperative pain control.

  The Journal of international medical research 20110101

• Ultra-rapid opiate detoxification using dexmedetomidine under general anesthesia.

  Journal of opioid management 20110101

• Successful treatment of acute mania and perineal abscess using dexmedetomidine sedation as adjunctive therapy.

  BMJ case reports 20110101

• Premedication with dexmedetomidine alone or together with 0.5% lidocaine for IVRA.

  The Journal of surgical research 20101201

• Successful treatment of ifosfamide neurotoxicity with dexmedetomidine.

  Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20101201

• Management of a tumor in the distal trachea while maintaining spontaneous ventilation.

  Journal of anesthesia 20101201

• Dexmedetomidine versus fentanyl as adjuvant to propofol: comparative study in children undergoing extracorporeal shock wave lithotripsy.

  European journal of anaesthesiology 20101201

• Deterioration of myocardial injury due to dexmedetomidine administration after myocardial ischaemia.

  Resuscitation 20101201

• Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat.

  The Journal of pharmacology and experimental therapeutics 20101201

• Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients.

  Critical care medicine 20101201

• Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block.

  Anesthesia and analgesia 20101201

• Dexmedetomidine-ketamine and midazolam-ketamine combinations for sedation in pediatric patients undergoing extracorporeal shock wave lithotripsy: a randomized prospective study.

  Journal of anesthesia 20101201

• Dexmedetomidine infusion for the management of opioid-induced hyperalgesia.

  Pain medicine (Malden, Mass.) 20101201

• Systemic daily morphine enhances the analgesic effect of intrathecal dexmedetomidine via up-regulation of alpha 2 adrenergic receptor subtypes A, B and C in dorsal root ganglion and dorsal horn.

  The Journal of pharmacy and pharmacology 20101201

• Acute hemodynamic changes after rapid intravenous bolus dosing of dexmedetomidine in pediatric heart transplant patients undergoing routine cardiac catheterization.

  Anesthesia and analgesia 20101201

• Dexmedetomidine: clinical application as an adjunct for intravenous regional anesthesia.

  Anesthesiology clinics 20101201

• All this confusion is killin' me.

  Critical care medicine 20101201

• Dexmedetomidine was safely used for sedation during spinal anesthesia in a very elderly patient.

  Journal of anesthesia 20101201

• Evaluation of dexmedetomidine versus propofol-based sedation therapy in mechanically ventilated cardiac surgery patients at a tertiary academic medical center.

  Critical pathways in cardiology 20101201

• Dexmedetomidine: exploring its potential role and dosing guideline for its use in intractable pain in the palliative care setting.

  Journal of pain & palliative care pharmacotherapy 20101201

• Use of dexmedetomidine and ketamine infusions during scoliosis repair surgery with somatosensory and motor-evoked potential monitoring: a case report.

  AANA journal 20101201

• Efficacy of intra-articular dexmedetomidine for postoperative analgesia in arthroscopic knee surgery.

  The Ceylon medical journal 20101201

• Voiding effects mediated by α2-adrenoceptors in the anaesthetized male rat.

  BJU international 20101101

• Patient-controlled sedation: a novel approach to sedation management for mechanically ventilated patients.

  Chest 20101101

• Astrocytic transactivation by alpha2A-adrenergic and 5-HT2B serotonergic signaling.

  Neurochemistry international 20101101

• Comparison of local anaesthesia with dexmedetomidine sedation and general anaesthesia during septoplasty.

  European journal of anaesthesiology 20101101

• Comment on dexmedetomidine systematic review and meta-analysis methodology.

  Intensive care medicine 20101101

• Midazolam enhances the analgesic properties of dexmedetomidine in the rat.

  Veterinary anaesthesia and analgesia 20101101

• Dexmedetomidine and ketamine for sedation during spinal anesthesia in children.

  Journal of clinical anesthesia 20101101

• [Some adjuvants added to local anesthetics improve the duration and quality of epidural anesthesia].

  Masui. The Japanese journal of anesthesiology 20101101

• Effect of single-dose dexmedetomidine on emergence agitation and recovery profiles after sevoflurane anesthesia in pediatric ambulatory surgery.

  Journal of anesthesia 20101001

• Awake intubation under sedation using target-controlled infusion of dexmedetomidine: five case reports.

  Journal of anesthesia 20101001

• Brain tissue oxygenation during dexmedetomidine administration in surgical patients with neurovascular injuries.

  Journal of neurosurgical anesthesiology 20101001

• Evidence for suppression of spinal glial activation by dexmedetomidine in a rat model of monoarthritis.

  Clinical and experimental pharmacology & physiology 20101001

• Dexmedetomidine infusion for analgesia and prevention of emergence agitation in children with obstructive sleep apnea syndrome undergoing tonsillectomy and adenoidectomy.

  Anesthesia and analgesia 20101001

• The effects of L-659,066, a peripheral α2-adrenoceptor antagonist, and verapamil on the cardiovascular influences of dexmedetomidine in conscious sheep.

  Journal of veterinary pharmacology and therapeutics 20101001

• Patient agitation and dexmedetomidine.

  The Nurse practitioner 20101001

• [The role of dexmedetomidine in treatment of serious patients in intensive care unit].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101001

• [The use of dexmedetomidine hydrochloride in intensive care unit].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101001

• Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100901

• Cognitive improvement during continuous sedation in critically ill, awake and responsive patients: the Acute Neurological ICU Sedation Trial (ANIST).

  Intensive care medicine 20100901

• Dexmedetomidine for awake fibreoptic intubation and awake self-positioning in a patient with a critically located cervical lesion for surgical removal of infra-tentorial tumour.

  Anaesthesia 20100901

• Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

  Anaesthesia 20100901

• Sedative and cardiorespiratory effects of dexmedetomidine and buprenorphine administered to cats via oral transmucosal or intramuscular routes.

  Veterinary anaesthesia and analgesia 20100901

• Ultrasound-guided nerve blocks of the pelvic limb in dogs.

  Veterinary anaesthesia and analgesia 20100901

• Dexmedetomidine and pulmonary artery pressure in the pediatric cardiac surgery patient--A new insight.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100901

• Dexmedetomidine as a postoperative sedative after congenital cardiac surgery--Consideration of the anesthetic management has an important role.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100901

• Dexmedetomidine-ketamine combination mitigates pulmonary type-2 cationic amino acid transporter isozymes upregulation in hemorrhagic shock rats.

  Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20100901

• Dexmedetomidine for anesthetic management of anterior mediastinal mass.

  Journal of anesthesia 20100801

• Monitored anesthesia care with dexmedetomidine of a patient with severe pulmonary arterial hypertension for inguinal hernioplasty.

  Journal of anesthesia 20100801

• The effects of intravenous dexmedetomidine on spinal hyperbaric ropivacaine anesthesia.

  Journal of anesthesia 20100801

• Anaesthesia or sedation for MRI in children.

  Current opinion in anaesthesiology 20100801

• The effect of intraoperative dexmedetomidine on postoperative analgesia and sedation in pediatric patients undergoing tonsillectomy and adenoidectomy.

  Anesthesia and analgesia 20100801

• Dexmedetomidine in the care of critically ill patients from 2001 to 2007: an observational cohort study.

  Anesthesiology 20100801

• High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without alpha(2) adrenoceptor activation.

  British journal of pharmacology 20100801

• Dexmedetomidine sedation for awake tracheotomy: case report and literature review.

  Journal of clinical anesthesia 20100801

• Prolonged infusions of dexmedetomidine in critically ill patients.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100801

• Pharmacologic options for reducing the shivering response to therapeutic hypothermia.

  Pharmacotherapy 20100801

• [Two cases of cervical carotid artery stenosis with high risk post-operative hyperperfusion treated with dexmedetomidine after carotid endarterectomy].

  No shinkei geka. Neurological surgery 20100801

• Considerations for the use of anesthetics in neurotoxicity studies.

  Comparative medicine 20100801

• Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic-induced neuroapoptosis in the rat developing brain.

  Acta anaesthesiologica Scandinavica 20100701

• Effect of epidural dexmedetomidine on intraoperative awareness and post-operative pain after one-lung ventilation.

  Acta anaesthesiologica Scandinavica 20100701

• A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.

  European journal of anaesthesiology 20100701

• Cardiopulmonary effects of two constant rate infusions of dexmedetomidine in isoflurane anaesthetized ponies.

  Veterinary anaesthesia and analgesia 20100701

• Use of dexmedetomidine in sustained ventricular tachycardia.

  Anaesthesia and intensive care 20100701

• [The effect of perioperative infused dexmedetomidine on postoperative analgesic consumption in mastoidectomy operations].

  Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology 20100701

• [Comparison of the activity and reliability of intravenous administration of midazolam and dexmedetomidine on sedation levels under epidural anesthesia].

  Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology 20100701

• Dexmedetomidine and the successful management of electroconvulsive therapy postictal agitation: a case report.

  The journal of ECT 20100601

• Pain relief during dressing changes of major adult burns: ideal analgesic combination with ketamine.

  Burns : journal of the International Society for Burn Injuries 20100601

• Evaluating the use of dexmedetomidine in neurocritical care patients.

  Neurocritical care 20100601

• Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis.

  Intensive care medicine 20100601

• The effects of dexmedetomidine dosage on cerebral vasospasm in a rat subarachnoid haemorrhage model.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100601

• Effect of increasing depth of dexmedetomidine anesthesia on upper airway morphology in children.

  Paediatric anaesthesia 20100601

• Incidence and predictors of hypertension during high-dose dexmedetomidine sedation for pediatric MRI.

  Paediatric anaesthesia 20100601

• Susceptibility of transcranial electric motor-evoked potentials to varying targeted blood levels of dexmedetomidine during spine surgery.

  Anesthesiology 20100601

• Intensive care unit delirium.

  Critical care nursing clinics of North America 20100601

• The role of the alpha 2A-adrenoceptor in mouse stress-coping behaviour.

  Psychoneuroendocrinology 20100501

• Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease.

  Intensive care medicine 20100501

• Comparison of three anaesthetic protocols in Bennett's wallabies (Macropus rufogriseus).

  Veterinary anaesthesia and analgesia 20100501

• A prospective, randomized, placebo-controlled study evaluating the efficacy of dexmedetomidine for sedation during vascular procedures.

  Vascular and endovascular surgery 20100501

• Dexmedetomidine hemodynamics in children after cardiac surgery.

  Paediatric anaesthesia 20100501

• Dexmedetomidine blocks thermal hyperalgesia and spinal glial activation in rat model of monoarthritis.

  Acta pharmacologica Sinica 20100501

• Combination of high-dose dexmedetomidine sedation and fascia iliaca compartment block for hip fracture surgery.

  Journal of clinical anesthesia 20100501

• Population pharmacokinetics of dexmedetomidine in infants after open heart surgery.

  Anesthesia and analgesia 20100501

• Effects of fentanyl-lidocaine-propofol and dexmedetomidine-lidocaine-propofol on tracheal intubation without use of muscle relaxants.

  The Kaohsiung journal of medical sciences 20100501

• [A combination of dexmedetomidine with ketamine and opioids results in significant inhibition of hemodynamic changes associated with laparoscopic cholecystectomy and in prolongation of postoperative analgesia].

  Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti 20100501

• The effectiveness of dexmedetomidine in experimental spinal cord injury compared to methylprednisolone in rats.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100401

• Hemodynamics and bispectral index (BIS) of dogs anesthetized with midazolam and ketamine associated with medetomidine or dexmedetomidine and submitted to ovariohysterectomy.

  Acta cirurgica brasileira 20100401

• Propofol/dexmedetomidine and propofol/ketamine combinations for anesthesia in pediatric patients undergoing transcatheter atrial septal defect closure: a prospective randomized study.

  Clinical therapeutics 20100401

• Anesthetic management of a pituitary tumor resection with dexmedetomidine.

  AANA journal 20100401

• The alpha(2)-adrenoceptor agonist dexmedetomidine suppresses memory formation only at doses attenuating the perception of sensory input.

  European journal of pharmacology 20100310

• Overview of total intravenous anesthesia in children.

  Paediatric anaesthesia 20100301

• Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats.

  Acta anaesthesiologica Scandinavica 20100301

• Addition of dexmedetomidine to bupivacaine for greater palatine nerve block prolongs postoperative analgesia after cleft palate repair.

  European journal of anaesthesiology 20100301

• Intraoperative administration of dexmedetomidine reduces the analgesic requirements for children undergoing hypospadius surgery.

  European journal of anaesthesiology 20100301

• Sedation trends in the 21st century: the transition to dexmedetomidine for radiological imaging studies.

  Paediatric anaesthesia 20100301

• Dexmedetomidine: perioperative applications in children.

  Paediatric anaesthesia 20100301

• Pretreatment with dexmedetomidine or thiopental decreases myoclonus after etomidate: a randomized, double-blind controlled trial.

  The Journal of surgical research 20100301

• A comparison of the effectiveness of dexmedetomidine versus propofol target-controlled infusion for sedation during fibreoptic nasotracheal intubation.

  Anaesthesia 20100301

• [Incidence and duration of postoperative delirium after cardiac surgery : Comparison between dexmedetomidine and morphine for postoperative sedation and analgesia].

  Der Anaesthesist 20100301

• [Effect of the initial loading dose of dexmedetomidine on hemodynamics in pediatric patients undergoing cardiac surgery].

  Masui. The Japanese journal of anesthesiology 20100301

• Cardiopulmonary and isoflurane-sparing effects of epidural or intravenous infusion of dexmedetomidine in cats undergoing surgery with epidural lidocaine.

  Veterinary anaesthesia and analgesia 20100301

• Combination of dexmedetomidine with buprenorphine enhances the antinociceptive effect to a thermal stimulus in the cat compared with either agent alone.

  Veterinary anaesthesia and analgesia 20100301

• Dexmedetomidine and magnesium sulfate in the perioperative management of a child undergoing laparoscopic resection of bilateral pheochromocytomas.

  Journal of clinical anesthesia 20100301

• Dexmedetomidine infusion during surgery in patients with a pheochromocytoma.

  Acta anaesthesiologica Scandinavica 20100301

• The effect of dexmedetomidine on liver histopathology in a rat sepsis model: an experimental pilot study.

  Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20100301

• Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception.

  European journal of pain (London, England) 20100201

• A cost-minimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit.

  Critical care medicine 20100201

• Use of dexmedetomidine for primary sedation in a general intensive care unit.

  Critical care nurse 20100201

• Airway catastrophes.

  Current opinion in anaesthesiology 20100201

• A comparison of propofol and dexmedetomidine for intravenous sedation: a randomized, crossover study of the effects on the central and autonomic nervous systems.

  Anesthesia and analgesia 20100201

• Dexmedetomidine for procedural sedation in the emergency department.

  European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20100201

• Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype.

  Journal of hypertension 20100201

• Assessing the comparative value of sedatives in the intensive care unit.

  Critical care medicine 20100201

• Characterization of the postconditioning effect of dexmedetomidine in mouse organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation.

  Anesthesiology 20100201

• Prolonged recovery associated with dexmedetomidine when used as a sole sedative agent in office-based oral and maxillofacial surgery procedures.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20100201

• Buccal administration of dexmedetomidine as a preanesthetic in children.

  Journal of anesthesia 20100201

• Dexmedetomidine is an excellent agent for sedation status-post lung transplant.

  Journal of clinical anesthesia 20100201

• A comparative study of dexmedetomidine with midazolam and midazolam alone for sedation during elective awake fiberoptic intubation.

  Journal of clinical anesthesia 20100201

• Bradycardia leading to asystole during dexmedetomidine infusion in an 18 year-old double-lung transplant recipient.

  Journal of clinical anesthesia 20100201

• Use of dexmedetomidine as the main anesthetic agent in patients with laryngo-tracheomalacia--a case report.

  Middle East journal of anaesthesiology 20100201

• The effectiveness of dexmedetomidine infusion for sedating oral cancer patients undergoing awake fibreoptic nasal intubation.

  European journal of anaesthesiology 20100101

• Dexmedetomidine sedation in children after cardiac surgery.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100101

• Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial.

  Anesthesia and analgesia 20100101

• Peri-operative use of dexmedetomidine in airway reconstruction surgery for obstructive sleep apnoea.

  The Journal of laryngology and otology 20100101

• New insights about an old foe.

  Anesthesiology 20100101

• Effects of dexmedetomidine and propofol on lower esophageal sphincter and gastroesophageal pressure gradient in healthy volunteers.

  Anesthesiology 20100101

• Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20100101

• Withdrawal from multiple sedative agent therapy in an infant: is dexmedetomidine the cause or the cure?

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100101

• Dexmedetomidine and pediatric (cardiac) critical care--are we there yet?

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100101

• Dexmedetomidine: are tolerance and withdrawal going to be an issue with long-term infusions?

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100101

• Dexmedetomidine as an adjunct to anesthetic induction to attenuate hemodynamic response to endotracheal intubation in patients undergoing fast-track CABG.

  Annals of cardiac anaesthesia 20100101

• Dexmedetomidine in the neurointensive care unit.

  Discovery medicine 20100101

• Novel use of intraoperative dexmedetomidine infusion for sedation during spinal cord stimulator lead placement via surgical laminectomy.

  Pain physician 20100101

• Effect of dexmedetomidine on testicular torsion/detorsion damage in rats.

  Urologia internationalis 20100101

• [Effect of dexmedetomidine on bispectral index and auditory evoked potential index during anesthesia with target controlled infusion of propofol and remifentanyl].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20100101

• The effect of dexmedetomidine on agitation during weaning of mechanical ventilation in critically ill patients.

  Anaesthesia and intensive care 20100101

• Optimizing sustained use of sedation in mechanically ventilated patients: focus on safety.

  Current drug safety 20100101

• Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial.

  Critical care (London, England) 20100101

• Evaluation of the hypnotic and hemodynamic effects of dexmedetomidine on propofol-sedated swine.

  Experimental animals 20100101

• A Phase IIIb, randomized, double-blind, placebo-controlled, multicenter study evaluating the safety and efficacy of dexmedetomidine for sedation during awake fiberoptic intubation.

  American journal of therapeutics 20100101

• The complex interplay between delirium, sepsis and sedation.

  Critical care (London, England) 20100101

• The use of sub-anesthetic intravenous ketamine and adjuvant dexmedetomidine when treating acute pain from CRPS.

  Pain physician 20100101

• Hemodynamic effects of the combination of dexmedetomidine-fentanyl versus midazolam-fentanyl in children undergoing cardiac surgery with cardiopulmonary bypass.

  Revista brasileira de anestesiologia 20100101

• Alpha-2 adrenoceptor agonists and sepsis: improved survival?

  Critical care (London, England) 20100101

• Perineural dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block.

  Regional anesthesia and pain medicine 20100101

• A comparison of intravenous sedation with two doses of dexmedetomidine: 0.2 µg/kg/hr Versus 0.4 µg/kg/hr.

  Anesthesia progress 20100101

• Analysis of heart rate variability dynamics during propofol and dexmedetomidine anesthesia.

  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20100101

• Determination of dexmedetomidine in human plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: application to a pharmacokinetic study.

  Journal of pharmaceutical and biomedical analysis 20091205

• Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit.

  Journal of critical care 20091201

• ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors.

  Neurochemistry international 20091201

• Re: The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage (Cosar et al. Surg Neurol 2009;71:54-59).

  Surgical neurology 20091201

• A new dosing protocol reduces dexmedetomidine-associated hypotension in critically ill surgical patients.

  Journal of critical care 20091201

• Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models.

  Naunyn-Schmiedeberg's archives of pharmacology 20091201

• The correlation between bispectral index and observational sedation scale in volunteers sedated with dexmedetomidine and propofol.

  Anesthesia and analgesia 20091201

• Effects of propofol and dexmedetomidine on indocyanine green elimination assessed with LIMON to patients with early septic shock: a pilot study.

  Journal of critical care 20091201

• An updated focused review of dexmedetomidine in adults.

  The Annals of pharmacotherapy 20091201

• A balanced anesthesia with dexmedetomidine decreases postoperative nausea and vomiting after laparoscopic surgery.

  Saudi medical journal 20091201

• Impact of dexmedetomidine on analgesic requirements in patients after cardiac surgery in a fast-track recovery room setting.

  Pharmacotherapy 20091201

• Dexmedetomidine-associated bradycardia progressing to pulseless electrical activity: case report and review of the literature.

  Pharmacotherapy 20091201

• Awake laminotomy and discectomy using Dexmedetomidine as anesthetic.

  Puerto Rico health sciences journal 20091201

• Effects of dexmedetomidine sedation on the EEG in children.

  Paediatric anaesthesia 20091201

• [Effect of dexmedetomidine on anesthetic requirements in cardiovascular surgery].

  Masui. The Japanese journal of anesthesiology 20091201

• [Apnea and severe respiratory depression induced by dexmedetomidine after general anesthesia in intensive care unit].

  Masui. The Japanese journal of anesthesiology 20091201

• Dexmedetomidine use in a pediatric cardiac intensive care unit: can we use it in infants after cardiac surgery?

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20091101

• Dexmedetomidine pharmacokinetics in pediatric intensive care--a pooled analysis.

  Paediatric anaesthesia 20091101

• 'Above all, do no harm': hippocrates.

  Anesthesiology 20091101

• Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study).

  Anesthesiology 20091101

• Comparison between dexmedetomidine and remifentanil for intraoperative controlled hypotension.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20091101

• Perineural dexmedetomidine added to ropivacaine causes a dose-dependent increase in the duration of thermal antinociception in sciatic nerve block in rat.

  Anesthesiology 20091101

• Dexmedetomidine as sole sedative during percutaneous carotid artery stenting in a patient with severe chronic obstructive pulmonary disease.

  Minerva anestesiologica 20091101

• Traumatic brain injury: neuroprotective anaesthetic techniques, an update.

  Injury 20091101

• [Perioperative management of a patient with myasthenia gravis using dexmedetomidine].

  Masui. The Japanese journal of anesthesiology 20091101

• Profound reduction in sedation and analgesic requirements using extended dexmedetomidine infusions in a patient with an open abdomen.

  Military medicine 20091101

• Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in children.

  Journal of clinical anesthesia 20091101

• Alpha-2 adrenergic agonists for the prevention of cardiac complications among patients undergoing surgery.

  The Cochrane database of systematic reviews 20091007

• Benzodiazepines for delirium.

  The Cochrane database of systematic reviews 20091007

• Evaluation of cardiorespiratory effects of combinations of dexmedetomidine and atropine in cats.

  Journal of feline medicine and surgery 20091001

• The combined neuroprotective effects of lidocaine and dexmedetomidine after transient forebrain ischemia in rats.

  Acta anaesthesiologica Scandinavica 20091001

• The effect of dexmedetomidine sedation on brachial plexus block in patients with end-stage renal disease.

  European journal of anaesthesiology 20091001

• Thermal antinociception after dexmedetomidine administration in cats: a comparison between intramuscular and oral transmucosal administration.

  Journal of feline medicine and surgery 20091001

• Sedation and regional anesthesia.

  Current opinion in anaesthesiology 20091001

• Dexmedetomidine-ketamine combination mitigates acute lung injury in haemorrhagic shock rats.

  Resuscitation 20091001

• Cardiovascular reflex responses to temporal reduction in arterial pressure during dexmedetomidine infusion: a double-blind, randomized, and placebo-controlled study.

  British journal of anaesthesia 20091001

• Dexmedetomidine for awake fiberoptic intubation in a parturient with spinal muscular atrophy type III for cesarean delivery.

  International journal of obstetric anesthesia 20091001

• Re: Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children.

  British journal of anaesthesia 20091001

• Successful use of dexmedetomidine for sedation in a 24-week gestational age neonate.

  The Annals of pharmacotherapy 20091001

• Prolonged dexmedetomidine infusions in critically ill infants and children.

  Indian pediatrics 20090901

• Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury.

  Acta anaesthesiologica Scandinavica 20090901

• Dexmedetomidine and proprofol in complex microlaryngeal surgery in infants.

  International journal of pediatric otorhinolaryngology 20090901

• Evaluation of the muscular relaxant effect of dexmedetomidine or medetomidine in cats.

  Veterinary research communications 20090901

• Perioperative use of dexmedetomidine in an infant with familial dysautonomia.

  British journal of anaesthesia 20090901

• Dexmedetomidine chemical restraint of two raptor species undergoing inhalation anaesthesia.

  Veterinary research communications 20090901

• Alpha2-receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients.

  The Annals of pharmacotherapy 20090901

• A comparison of dexmedetomidine with propofol for magnetic resonance imaging sleep studies in children.

  Anesthesia and analgesia 20090901

• Sedation and drugs in pediatric patients: what is new?

  Paediatric anaesthesia 20090901

• New caudal additives in children: benefit vs. risk?

  Acta anaesthesiologica Scandinavica 20090901

• Update on dexmedetomidine for adult ICU sedation.

  Connecticut medicine 20090901

• Sedation challenges in the pediatric ICU: is dexmedetomidine the solution?

  Indian pediatrics 20090901

• Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.

  Journal of clinical anesthesia 20090901

• Dexmedetomidine/ketamine for diagnostic cardiac catheterization in a child with idiopathic pulmonary hypertension.

  Journal of clinical anesthesia 20090901

• Dexmedetomidine supplemented with local anesthesia for awake laryngoplasty.

  Journal of clinical anesthesia 20090901

• The influences of propofol and dexmedetomidine on circadian gene expression in rat brain.

  Brain research bulletin 20090814

• Risk and safety of pediatric sedation/anesthesia for procedures outside the operating room.

  Current opinion in anaesthesiology 20090801

• Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children.

  British journal of anaesthesia 20090801

• Dexmedetomidine, an alpha2-adrenergic agonist, inhibits neuronal delayed-rectifier potassium current and sodium current.

  British journal of anaesthesia 20090801

• Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.

  Pediatric neurology 20090801

• The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors.

  Anesthesia and analgesia 20090801

• Using a thoracic epidural catheter in a high-risk pediatric transplant patient.

  The Annals of thoracic surgery 20090801

• [Effect of dexmedetomidine on intraoperative somatosensory evoked potential monitoring].

  Masui. The Japanese journal of anesthesiology 20090801

• [Cardiac arrest induced by dexmedetomidine].

  Masui. The Japanese journal of anesthesiology 20090801

• [Anesthetic management in a case of myotonic distrophy with dexmedetomidine].

  Masui. The Japanese journal of anesthesiology 20090801

• Dexmedetomidine use in general anaesthesia.

  Current drug targets 20090801

• New drugs for epidural analgesia.

  Current drug targets 20090801

• Cesarean section and primary pulmonary hypertension: the role of intravenous dexmedetomidine.

  International journal of obstetric anesthesia 20090701

• Intravenous dexmedetomidine as an adjunct for labor analgesia and cesarean delivery anesthesia in a parturient with a tethered spinal cord.

  International journal of obstetric anesthesia 20090701

• Intravenous dexmedetomidine for obstetric anaesthesia and analgesia: converting a challenge into an opportunity?

  International journal of obstetric anesthesia 20090701

• Suppression of shivering during hypothermia using a novel drug combination in healthy volunteers.

  Anesthesiology 20090701

• A comparison of the effects on respiratory carbon dioxide response, arterial blood pressure, and heart rate of dexmedetomidine, propofol, and midazolam in sevoflurane-anesthetized rabbits.

  Anesthesia and analgesia 20090701

• Pharmacology of sedative-analgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists.

  Critical care clinics 20090701

• The effects of dexmedetomidine and fentanyl on emergence characteristics after adenoidectomy in children.

  Anaesthesia and intensive care 20090701

• Comparing dexmedetomidine with midazolam for sedation of patients in the ICU.

  JAMA 20090617

• Comparing dexmedetomidine with midazolam for sedation of patients in the ICU.

  JAMA 20090617

• Comparing dexmedetomidine with midazolam for sedation of patients in the ICU.

  JAMA 20090617

• Comparing dexmedetomidine with midazolam for sedation of patients in the ICU.

  JAMA 20090617

• Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophages.

  The Journal of surgical research 20090615

• Intravenous dexmedetomidine prolongs bupivacaine spinal analgesia.

  Middle East journal of anaesthesiology 20090601

• Sedating the child with congenital heart disease.

  Anesthesiology clinics 20090601

• Bispectral index-guided intraoperative sedation with dexmedetomidine and midazolam infusion in outpatient cataract surgery.

  Minerva anestesiologica 20090501

• The use of dexmedetomidine in critically ill children.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20090501

• Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats.

  Anesthesiology 20090501

• Postoperative intensive care unit drug fever caused by dexmedetomidine.

  Anesthesia and analgesia 20090501

• Influence of anesthetic management on quality of magnetoencephalography scan data in pediatric patients: a case series.

  Paediatric anaesthesia 20090501

• Dexmedetomidine suppresses the decrease in blood pressure during anesthetic induction and blunts the cardiovascular response to tracheal intubation.

  Journal of clinical anesthesia 20090501

• Dexmedetomidine for deep brain stimulator placement in a child with primary generalized dystonia: case report and literature review.

  Journal of clinical anesthesia 20090501

• Dexmedetomidine blunts haemodynamic and intraocular pressure responses to tracheal intubation.

  European journal of anaesthesiology 20090501

• Altered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitis.

  World journal of gastroenterology 20090407

• Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis.

  Brain research 20090406

• Direct effect of dexmedetomidine on rat isolated aorta involves endothelial nitric oxide synthesis and activation of the lipoxygenase pathway.

  Clinical and experimental pharmacology & physiology 20090401

• Severe rash associated with dexmedetomidine use during mechanical ventilation.

  Pharmacotherapy 20090401

• Alpha2-adrenergic agonists and their role in the prevention of perioperative adverse cardiac events.

  AANA journal 20090401

• Does dexmedetomidine reduce secondary damage after spinal cord injury? An experimental study.

  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20090301

• Dexmedetomidine sedation for pediatric post-Fontan procedure patients.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20090301

• Clonidine and dexmedetomidine produce antinociceptive synergy in mouse spinal cord.

  Anesthesiology 20090301

• An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine.

  Anesthesia and analgesia 20090301

• Effect of dexmedetomidine added to spinal bupivacaine for urological procedures.

  Saudi medical journal 20090301

• [Anesthesia induction for patients with cervical spinal disease].

  Masui. The Japanese journal of anesthesiology 20090301

• Effects of alpha-adrenergic agonists on pain modulation in diffuse noxious inhibitory control.

  Journal of medical and dental sciences 20090301

• A new era for sedation in ICU patients.

  JAMA 20090204

• Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial.

  JAMA 20090204

• Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation.

  Intensive care medicine 20090201

• Does pethidine affect the cardiovascular and sedative effects of dexmedetomidine in dogs?

  The Journal of small animal practice 20090201

• Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics.

  Acta anaesthesiologica Scandinavica 20090201

• Dexmedetomidine anaesthesia for patients with obstructive sleep apnoea undergoing bariatric surgery.

  European journal of anaesthesiology 20090201

• Prolonged use of dexmedetomidine in the paediatric cardiothoracic intensive care unit.

  Cardiology in the young 20090201

• Propofol and midazolam inhibit conscious memory processes very soon after encoding: an event-related potential study of familiarity and recollection in volunteers.

  Anesthesiology 20090201

• [Planned sedation with dexmedetomidine hydrochloride after pediatric cardiac surgery; an institutional experience].

  Kyobu geka. The Japanese journal of thoracic surgery 20090201

• Determination of the pharmacodynamic interaction of propofol and dexmedetomidine during esophagogastroduodenoscopy in children.

  Paediatric anaesthesia 20090201

• Hypoglycemia associated with dexmedetomidine overdose in a child?

  Journal of clinical anesthesia 20090201

• Expressions of genes encoding drug-metabolizing enzymes are altered after sevoflurane, isoflurane, propofol or dexmedetomidine anesthesia.

  Biomedical research (Tokyo, Japan) 20090201

• Remifentanil-propofol vs dexmedetomidine-propofol--anesthesia for supratentorial craniotomy.

  Middle East journal of anaesthesiology 20090201

• Benzodiazepines for delirium.

  The Cochrane database of systematic reviews 20090121

• The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage.

  Surgical neurology 20090101

• Effect of combining dexmedetomidine and morphine for intravenous patient-controlled analgesia.

  British journal of anaesthesia 20090101

• Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers.

  British journal of anaesthesia 20090101

• Propofol-sparing or lipid-sparing?

  Paediatric anaesthesia 20090101

• Dexmedetomidine sedation (and cardiac perforation, pericardial tamponade, cardiac arrest, and cardiopulmonary resuscitation) leading to refractory cardiogenic shock.

  Anesthesia and analgesia 20090101

• Caution is necessary when dexmedetomidine is used off-label, especially when combined with other sedatives.

  Anesthesia and analgesia 20090101

• Dexmedetomidine and refractory cardiogenic shock.

  Anesthesia and analgesia 20090101

• Intravenous dexmedetomidine infusion for labour analgesia in patient with preeclampsia.

  European journal of anaesthesiology 20090101

• Addition of dexmedetomidine or lornoxicam to prilocaine in intravenous regional anaesthesia for hand or forearm surgery: a randomized controlled study.

  Clinical drug investigation 20090101

• Dexmedetomidine as a substitute for remifentanil in ambulatory gynecologic laparoscopic surgery.

  Saudi medical journal 20090101

• Effect of dexmedetomidine on ischemia-reperfusion injury in rat kidney: a histopathologic study.

  Renal failure 20090101

• [Anesthetic management using epidural anesthesia and dexmedetomidine for thoracoscopic lung resection in a patient with compromised lung functions].

  Masui. The Japanese journal of anesthesiology 20090101

• Awake thyroidectomy under local anesthesia and dexmedetomidine infusion.

  Military medicine 20090101

• Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventional study.

  Critical care (London, England) 20090101

• Premedication with dexmedetomidine and midazolam attenuates agitation after electroconvulsive therapy.

  Journal of anesthesia 20090101

• Dexmedetomidine facilitates induction of noninvasive positive pressure ventilation for acute respiratory failure in patients with severe asthma.

  Journal of anesthesia 20090101

• Treating agitation with dexmedetomidine in the ICU.

  Dimensions of critical care nursing : DCCN 20090101

• BIS and spectral entropy monitoring during sedation with midazolam/remifentanil and dexmedetomidine/remifentanil.

  Critical care (London, England) 20090101

• Opioid-free balanced anesthesia for cervical ganglionectomy subsequent to recent ultra rapid opioid detoxification.

  Pain medicine (Malden, Mass.) 20090101

• Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial.

  Critical care (London, England) 20090101

• Intranasal dexmedetomidine premedication is comparable with midazolam in burn children undergoing reconstructive surgery.

  Journal of burn care & research : official publication of the American Burn Association 20090101

• Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery.

  Psychosomatics 20090101

• Tackling agitated delirium--the tip of the iceberg.

  Critical care (London, England) 20090101

• Dexmedetomidine as a novel therapeutic for postoperative pain in a patient treated with buprenorphine.

  Journal of opioid management 20090101

• Dexmedetomidine-induced cerebral hypoperfusion exacerbates ischemic brain injury in rats.

  Journal of anesthesia 20090101

• Sedation improves early outcome in severely septic Sprague Dawley rats.

  Critical care (London, England) 20090101

• Dexmedetomidine sedation for carotid endarterectomy.

  Anestezjologia intensywna terapia 20090101

• Evaluation of the potential for interaction between a metaflumizone-amitraz combination and dexmedetomidine hydrochloride in dogs.

  Veterinary therapeutics : research in applied veterinary medicine 20090101

• Psychosedation with dexmedetomidine hydrochloride during minor oral surgery.

  Anesthesia progress 20090101

• Immunosedation: a consideration for sepsis.

  Critical care (London, England) 20090101

• Effects of dexmedetomidine pretreatment on bupivacaine cardiotoxicity in rats.

  Regional anesthesia and pain medicine 20090101

• Investigation of modulation of the alpha-2 receptor in tetrahydropalmatine (THP) analgesia in male Sprague-Dawley rats.

  Journal of dietary supplements 20090101

• In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action.

  European journal of pharmacology 20081203

• Dexmedetomidine causes prolonged recovery when compared with midazolam/fentanyl combination in outpatient shock wave lithotripsy.

  European journal of anaesthesiology 20081201

• Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine.

  British journal of pharmacology 20081201

• Anesthesia for outpatient cosmetic surgery.

  Current opinion in anaesthesiology 20081201

• A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging.

  Anesthesia and analgesia 20081201

• Recovery profiles from dexmedetomidine as a general anesthetic adjuvant in patients undergoing lower abdominal surgery.

  Anesthesia and analgesia 20081201

• Effects of dexmedetomidine on propofol and remifentanil infusion rates during total intravenous anesthesia for spine surgery in adolescents.

  Paediatric anaesthesia 20081201

• Dexmedetomidine: more than a sedative and analgesic.

  Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20081201

• Effects of dexmedetomidine on regulating pulmonary inflammation in a rat model of ventilator-induced lung injury.

  Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20081201

• Effects of dexmedetomidine on intraoperative motor and somatosensory evoked potential monitoring during spinal surgery in adolescents.

  Paediatric anaesthesia 20081101

• Dexmedetomidine infusion as adjunctive therapy to benzodiazepines for acute alcohol withdrawal.

  The Annals of pharmacotherapy 20081101

• Postoperative pain status after intraoperative systemic dexmedetomidine and epidural neostigmine in patients undergoing lower abdominal surgery.

  European journal of anaesthesiology 20081101

• Dexmedetomidine as the primary sedative during invasive procedures in infants and toddlers with congenital heart disease.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20081101

• Dexmedetomidine: a novel drug for the treatment of atrial and junctional tachyarrhythmias during the perioperative period for congenital cardiac surgery: a preliminary study.

  Anesthesia and analgesia 20081101

• Induced hypotension in orthognathic surgery: a comparative study of 2 pharmacological protocols.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20081101

• Advantageous effects of dexmedetomidine on haemodynamic and recovery responses during extubation for intracranial surgery.

  European journal of anaesthesiology 20081001

• Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice.

  British journal of pharmacology 20081001

• Anesthesia for functional neurosurgery: the role of dexmedetomidine.

  Current opinion in anaesthesiology 20081001

• The effect of dexmedetomidine on perioperative hemodynamics in patients undergoing craniotomy.

  Anesthesia and analgesia 20081001

• Anesthetic management of adenotonsillectomy in a child with bidirectional superior cavapulmonary shunt.

  Paediatric anaesthesia 20081001

• A combination of ketamine and dexmedetomidine sedation with caudal anesthesia during incarcerated inguinal hernia repair in three high-risk infants.

  Paediatric anaesthesia 20081001

• Dexmedetomidine and ketamine for large anterior mediastinal mass biopsy.

  Paediatric anaesthesia 20081001

• Dexmedetomidine weakens dynamic cerebral autoregulation as assessed by transfer function analysis and the thigh cuff method.

  Anesthesiology 20081001

• Future directions in endoscopic sedation.

  Gastrointestinal endoscopy clinics of North America 20081001

• Dexmedetomidine: a useful adjunct to consider in some high-risk situations.

  AANA journal 20081001

• Evaluation of analgesic and sedative effects of continuous infusion of dexmedetomidine by measuring somatosensory- and auditory-evoked potentials in the rat.

  Veterinary anaesthesia and analgesia 20080901

• The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs.

  Veterinary anaesthesia and analgesia 20080901

• Sedation during ophthalmic surgery.

  European journal of anaesthesiology 20080901

• Effect of intra-articular dexmedetomidine on postoperative analgesia after arthroscopic knee surgery.

  British journal of anaesthesia 20080901

• alpha2-Adrenergic agonists protect against radiocontrast-induced nephropathy in mice.

  American journal of physiology. Renal physiology 20080901

• Motor and somatosensory evoked potentials are well maintained in patients given dexmedetomidine during spine surgery.

  Anesthesiology 20080901

• Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat.

  Anesthesiology 20080901

• Dexmedetomidine-based versus fentanyl-based total intravenous anesthesia for lumbar laminectomy.

  Minerva anestesiologica 20080901

• Dexmedetomidine sedation for laryngeal framework surgery.

  The Annals of otology, rhinology, and laryngology 20080901

• Antimicrobial effects of two anaesthetic agents: dexmedetomidine and midazolam.

  Anaesthesia and intensive care 20080901

• The effects of preanesthetic, single-dose dexmedetomidine on induction, hemodynamic, and cardiovascular parameters.

  Journal of clinical anesthesia 20080901

• Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations.

  Journal of clinical anesthesia 20080901

• Dexmedetomidine and ketamine for fiberoptic intubation in a child with severe mandibular hypoplasia.

  Journal of clinical anesthesia 20080901

• Comparison of dexmedetomidine-propofol vs. fentanyl-propofol for laryngeal mask insertion.

  European journal of anaesthesiology 20080801

• Novel use of dexmedetomidine in a patient with pulmonary hypertension.

  Paediatric anaesthesia 20080801

• Dexmedetomidine disposition in children: a population analysis.

  Paediatric anaesthesia 20080801

• Intravenous dexmedetomidine decreases lung permeability induced by intracranial hypertension in rats.

  Anesthesia and analgesia 20080801

• Dexmedetomidine: a review of clinical applications.

  Current opinion in anaesthesiology 20080801

• Dexmedetomidine sedation in a patient with superior vena cava syndrome and extreme needle phobia.

  Journal of cardiothoracic and vascular anesthesia 20080801

• [Dexmedetomidine for sedation during voice monitoring surgery in a patient with an episode of seizure].

  Masui. The Japanese journal of anesthesiology 20080801

• The effects of dexmedetomidine on human neutrophil apoptosis.

  Biomedical research (Tokyo, Japan) 20080801

• Dexmedetomidine for sedation during electroencephalographic analysis in children with autism, pervasive developmental disorders, and seizure disorders.

  Journal of clinical anesthesia 20080801

• Effects of subchronic versus acute in utero exposure to dexmedetomidine on foetal developments in rats.

  Basic & clinical pharmacology & toxicology 20080801

• Dexmedetomidine and arousal affect subthalamic neurons.

  Movement disorders : official journal of the Movement Disorder Society 20080715

• The influence of dexmedetomidine on ischemic rat hippocampus.

  Brain research 20080707

• Severe hypertension and bradycardia after dexmedetomidine for radiology sedation in a patient with acute transverse myelitis.

  Paediatric anaesthesia 20080701

• Alpha2 adrenoreceptor agonist regulates protein kinase C-induced heat shock protein 27 phosphorylation in C6 glioma cells.

  Journal of neurochemistry 20080701

• Dexmedetomidine attenuates the hemodynamic and neuroendocrinal responses to skull-pin head-holder application during craniotomy.

  Journal of neurosurgical anesthesiology 20080701

• High dose of dexmedetomidine was useful for general anesthesia and post-operative analgesia in a patient with postpolio syndrome.

  Acta anaesthesiologica Scandinavica 20080701

• Intubation of an infant with Pierre Robin sequence under dexmedetomidine sedation using the Shikani Optical Stylet.

  Acta anaesthesiologica Scandinavica 20080701

• Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor.

  Anesthesia and analgesia 20080701

• The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study.

  Anesthesia and analgesia 20080701

• Sedative and cardiorespiratory effects of acepromazine or atropine given before dexmedetomidine in dogs.

  The Veterinary record 20080628

• Sedation with dexmedetomidine for vocal fold injection.

  The New Zealand medical journal 20080606

• A comparison of esmolol and dexmedetomidine for attenuation of intraocular pressure and haemodynamic responses to laryngoscopy and tracheal intubation.

  European journal of anaesthesiology 20080601

• Cost of dexmedetomidine in MRI.

  Paediatric anaesthesia 20080601

• Management of accidental spinal administration of extended-release epidural morphine.

  Anesthesiology 20080601

• Expecting the unexpected.

  Anesthesia and analgesia 20080601

• A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial.

  Anesthesia and analgesia 20080601

• Dexmedetomidine infusion during laparoscopic bariatric surgery: the effect on recovery outcome variables.

  Anesthesia and analgesia 20080601

• The effect of prolonged anesthesia with isoflurane, propofol, dexmedetomidine, or ketamine on neural cell proliferation in the adult rat.

  Anesthesia and analgesia 20080601

• Dexmedetomidine sedation leading to refractory cardiogenic shock.

  Anesthesia and analgesia 20080601

• [Postoperative management of carotid endarterectomy with dexmedetomidine--a comparison with propofol].

  Masui. The Japanese journal of anesthesiology 20080601

• [Ambulatory anesthesia for an adult patient with autism and epilepsy: sedation using oral and intravenous dexmedetomidine].

  Masui. The Japanese journal of anesthesiology 20080601

• Action of dexmedetomidine on the substantia gelatinosa neurons of the rat spinal cord.

  The European journal of neuroscience 20080601

• The use of continuous positive airway pressure during an awake craniotomy in a patient with obstructive sleep apnea.

  Journal of clinical anesthesia 20080601

• Autonomic cardiovascular control during a novel pharmacologic alternative to ganglionic blockade.

  Clinical pharmacology and therapeutics 20080501

• The efficacy and neurotoxicity of dexmedetomidine administered via the epidural route.

  European journal of anaesthesiology 20080501

• Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy.

  European journal of anaesthesiology 20080501

• Comparison between dexmedetomidine and remifentanil for controlled hypotension during tympanoplasty.

  European journal of anaesthesiology 20080501

• Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons.

  British journal of pharmacology 20080501

• High dose dexmedetomidine as the sole sedative for pediatric MRI.

  Paediatric anaesthesia 20080501

• Hemodynamic effects of dexmedetomidine sedation for CT imaging studies.

  Paediatric anaesthesia 20080501

• Pharmacokinetics of intravenous dexmedetomidine in children under 11 yr of age.

  British journal of anaesthesia 20080501

• The central hypotensive effect induced by alpha 2-adrenergic receptor stimulation is dependent on endothelial nitric oxide synthase.

  Journal of hypertension 20080501

• Dexmedetomidine: sedation, analgesia and beyond.

  Expert opinion on drug metabolism & toxicology 20080501

• Sertindole: pharmacological and clinical profile and role in the treatment of schizophrenia.

  Expert opinion on drug metabolism & toxicology 20080501

• Sedation with dexmedetomidine vs lorazepam in mechanically ventilated patients.

  JAMA 20080402

• Sedation with dexmedetomidine vs lorazepam in mechanically ventilated patients.

  JAMA 20080402

• Sedation with dexmedetomidine vs lorazepam in mechanically ventilated patients.

  JAMA 20080402

• Effect of dexmedetomidine premedication on the intraocular pressure changes after succinylcholine and intubation.

  British journal of anaesthesia 20080401

• Clinical efficacy of dexmedetomidine alone is less than propofol for conscious sedation during ERCP.

  Gastrointestinal endoscopy 20080401

• Thermal antinociception after dexmedetomidine administration in cats: a dose-finding study.

  Journal of veterinary pharmacology and therapeutics 20080401

• Transmucosal dexmedetomidine for computed tomography sedation.

  Paediatric anaesthesia 20080401

• Postoperative management of cleft lip repair using dexmedetomidine in a child with bidirectional superior cavopulmonary shunt.

  Paediatric anaesthesia 20080401

• [Use of high-dose dexmedetomidine infusion for anesthesia and sedation in a patient for microlaryngeal surgery maintained with spontaneous breathing].

  Masui. The Japanese journal of anesthesiology 20080401

• Dexmedetomidine constant rate infusion for 24 hours during and after propofol or isoflurane anaesthesia in dogs.

  Veterinary anaesthesia and analgesia 20080301

• Dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline I1 receptors.

  Anesthesiology 20080301

• Use of dexmedetomidine for sedation of children hospitalized in the intensive care unit.

  Journal of hospital medicine 20080301

• Dexmedetomidine blunts acute hyperdynamic responses to electroconvulsive therapy without altering seizure duration.

  Acta anaesthesiologica Scandinavica 20080201

• Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep.

  Acta anaesthesiologica Scandinavica 20080201

• Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine.

  Hypertension (Dallas, Tex. : 1979) 20080201

• Comparative effects of propofol vs dexmedetomidine on cerebrovascular carbon dioxide reactivity in patients with septic shock.

  British journal of anaesthesia 20080201

• Feasibility of dexmedetomidine in facilitating extubation in the intensive care unit.

  Journal of clinical pharmacy and therapeutics 20080201

• Effect of dexmedetomidine on cerebral blood flow velocity, cerebral metabolic rate, and carbon dioxide response in normal humans.

  Anesthesiology 20080201

• Pro: dexmedetomidine should be used for infants and children undergoing cardiac surgery.

  Journal of cardiothoracic and vascular anesthesia 20080201

• Con: dexmedetomidine should not be used for infants and children during cardiac surgery.

  Journal of cardiothoracic and vascular anesthesia 20080201

• [Ultra fast-track anesthesia with operating room extubation in a patient undergoing OPCABG by combination of propofol-remifentanil-dexmedetomidine].

  Masui. The Japanese journal of anesthesiology 20080201

• Successful intraoperative spinal cord monitoring during scoliosis surgery using a total intravenous anesthetic regimen including dexmedetomidine.

  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 20080201

• Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report.

  AANA journal 20080201

• Inhibitory effects of the alpha-2 adrenergic agonists clonidine and dexmedetomidine on enhanced airway tone in ovalbumin-sensitized guinea pigs.

  European journal of anaesthesiology 20080101

• Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(alpha)pyrene.

  Basic & clinical pharmacology & toxicology 20080101

• Dexmedetomidine and cardiac protection for non-cardiac surgery: a meta-analysis of randomised controlled trials.

  Anaesthesia 20080101

• Acute discontinuation syndrome from dexmedetomidine after protracted use in a pediatric patient.

  Paediatric anaesthesia 20080101

• Use of dexmedetomidine in the pediatric intensive care unit.

  Pharmacotherapy 20080101

• Dexmedetomidine reduces long-term potentiation in mouse hippocampus.

  Anesthesiology 20080101

• Perioperative events during deep brain stimulation: the experience at cleveland clinic.

  Journal of neurosurgical anesthesiology 20080101

• Clinical uses of dexmedetomidine in pediatric patients.

  Paediatric drugs 20080101

• The effects of dexmedetomidine on cardiac electrophysiology in children.

  Anesthesia and analgesia 20080101

• A comparison of sedation with dexmedetomidine or propofol during shockwave lithotripsy: a randomized controlled trial.

  Anesthesia and analgesia 20080101

• Dexmedetomidine in aesthetic facial surgery: improving anesthetic safety and efficacy.

  Plastic and reconstructive surgery 20080101

• Dexmedetomidine continuous rate infusion during isoflurane anaesthesia in canine surgical patients.

  Veterinary anaesthesia and analgesia 20080101

• Monitored anesthesia care with a combination of ketamine and dexmedetomidine during cardiac catheterization.

  American journal of therapeutics 20080101

• [Drug therapy of opioid withdrawal].

  Vertex (Buenos Aires, Argentina) 20080101

• Patient comfort and surgeon satisfaction during cataract surgery using topical anesthesia with or without dexmedetomidine sedation.

  European journal of ophthalmology 20080101

• High-dose dexmedetomidine-induced hypertension in a child with traumatic brain injury.

  Neurocritical care 20080101

• [Synergistic effect between dexmedetomidine and 0.75% ropivacaine in epidural anesthesia].

  Revista da Associacao Medica Brasileira (1992) 20080101

• Dexmedetomidine use in critical care.

  AACN advanced critical care 20080101

• Dexmedetomidine reduces the ischemia-reperfusion injury markers during upper extremity surgery with tourniquet.

  The Journal of hand surgery 20080101

• Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats.

  Journal of anesthesia 20080101

• Analgesic effect of dexmedetomidine in a patient with herpetic stomatitis after living-donor lung transplantation.

  Journal of anesthesia 20080101

• Sedation of hypercyanotic spells in a neonate with tetralogy of Fallot using dexmedetomidine.

  Jornal de pediatria 20080101

• Dexmedetomidine in anesthesia of children submitted to videolaparoscopic appendectomy: a double-blind, randomized and placebo-controlled study.

  Revista da Associacao Medica Brasileira (1992) 20080101

• Intravenous sedation with low-dose dexmedetomidine: its potential for use in dentistry.

  Anesthesia progress 20080101

• Bradycardia during dexmedetomidine and therapeutic hypothermia.

  Journal of intensive care medicine 20080101

• Subcutaneous dexmedetomidine infusions to treat or prevent drug withdrawal in infants and children.

  Journal of opioid management 20080101

• Preliminary experience with dexmedetomidine for monitored anesthesia care during ENT surgical procedures.

  American journal of therapeutics 20080101

• Dexmedetomidine alters the cardiovascular response during infra-renal aortic cross-clamping in sevoflurane-anesthetized dogs.

  Journal of investigative surgery : the official journal of the Academy of Surgical Research 20080101

• Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial.

  JAMA 20071212

• The use of dexmedetomidine during laryngoscopy, bronchoscopy, and tracheal extubation following tracheal reconstruction.

  Paediatric anaesthesia 20071201

• The effects of centrally administered dexmedetomidine on cardiovascular and sympathetic function in conscious rats.

  Anesthesia and analgesia 20071201

• Effects of epidural administration of dexmedetomidine on the minimum alveolar concentration of isoflurane in dogs.

  American journal of veterinary research 20071201

• Clinical analgesic efficacy and side effects of dexmedetomidine in the early postoperative period after arthroscopic knee surgery.

  Journal of clinical anesthesia 20071201

• Innovative uses of dexmedetomidine.

  Journal of clinical anesthesia 20071201

• Effects of alpha2-adrenoceptor agonists on tetrodotoxin-resistant Na+ channels in rat dorsal root ganglion neurons.

  European journal of anaesthesiology 20071101

• Analysis of the antinociceptive effect of systemic administration of tramadol and dexmedetomidine combination on rat models of acute and neuropathic pain.

  Pharmacology, biochemistry, and behavior 20071101

• The impact of perioperative dexmedetomidine infusion on postoperative narcotic use and duration of stay after laparoscopic bariatric surgery.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20071101

• A comparison of dexmedetomidine and midazolam for sedation in third molar surgery.

  Anaesthesia 20071101

• The effect of dexmedetomidine on electrocorticography in patients with temporal lobe epilepsy under sevoflurane anesthesia.

  Anesthesia and analgesia 20071101

• Effect of dexmedetomidine on blood pressure and bleeding in maxillo-facial surgery.

  European journal of anaesthesiology 20071101

• Dexmedetomidine-induced pulmonary alterations in sheep.

  Research in veterinary science 20071001

• Dexmedetomidine as an analgesic for pediatric tonsillectomy and adenoidectomy.

  Paediatric anaesthesia 20071001

• Dexmedetomidine sedation for the treatment of tetanus in the intensive care unit.

  British journal of anaesthesia 20071001

• Autonomic dysfunction in tetanus - what lessons can be learnt with specific reference to alpha-2 agonists?

  Anaesthesia 20071001

• Activation of a G protein-coupled inwardly rectifying K+ current and suppression of Ih contribute to dexmedetomidine-induced inhibition of rat hypothalamic paraventricular nucleus neurons.

  Anesthesiology 20071001

• Translational research: addressing problems facing the anesthesiologist.

  Anesthesia and analgesia 20071001

• Intravenous infusion of dexmedetomidine can prevent the degeneration of spinal ventral neurons induced by intrathecal morphine after a noninjurious interval of spinal cord ischemia in rats.

  Anesthesia and analgesia 20071001

• Dexmedetomidine relieves pain associated with acute sickle cell crisis.

  Journal of pain and symptom management 20071001

• Dexmedetomidine produces dual alpha2-adrenergic agonist and alpha1-adrenergic antagonist actions on human isolated internal mammary artery.

  Journal of cardiothoracic and vascular anesthesia 20071001

• [Efficacy of dexmedetomidine for controlling delirium in intensive care unit patients].

  Masui. The Japanese journal of anesthesiology 20071001

• [Usability of AirWay Scope for awake tracheal intubation in a burn patient with difficult airway].

  Masui. The Japanese journal of anesthesiology 20071001

• Effects of dexmedetomidine in morbidly obese patients undergoing laparoscopic gastric bypass.

  Middle East journal of anaesthesiology 20071001

• The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts.

  Resuscitation 20070901

• Dexmedetomidine for pediatric MRI sedation: a review of a series of cases.

  Paediatric anaesthesia 20070901

• Pharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: preliminary study.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20070901

• Dexmedetomidine during coronary artery bypass grafting surgery: is it neuroprotective?--A preliminary study.

  Acta anaesthesiologica Scandinavica 20070901

• Dexmedetomidine sedation during cataract surgery under regional anaesthesia.

  British journal of anaesthesia 20070901

• Deep sedation with dexmedetomidine in a porcine model does not compromise the viability of free microvascular flap as depicted by microdialysis and tissue oxygen tension.

  Anesthesia and analgesia 20070901

• Dexmedetomidine related cardiac arrest in a patient with permanent pacemaker; a cautionary tale.

  Pacing and clinical electrophysiology : PACE 20070901

• Dexmedetomidine: do we know enough?

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20070901

• Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans.

  Journal of the American College of Cardiology 20070814

• Characterization of spinal alpha-adrenergic modulation of nociceptive transmission and hyperalgesia throughout postnatal development in rats.

  British journal of pharmacology 20070801

• Anesthesia in the patient for awake craniotomy.

  Current opinion in anaesthesiology 20070801

• Current state of sedation/analgesia care in dentistry.

  Current opinion in anaesthesiology 20070801

• Current world literature.

  Current opinion in anaesthesiology 20070801

• Neonates have a spinal alpha receptor too, as do adults.

  British journal of pharmacology 20070801

• A double-blind, crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine.

  Anesthesia and analgesia 20070801

• The effect of dexmedetomidine on middle ear pressure.

  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20070801

• [Experience in postoperative sedation with dexmedetomidine for mandibular osteotomy].

  Masui. The Japanese journal of anesthesiology 20070801

• Dexmedetomidine as sole sedative for awake intubation in management of the critical airway.

  Journal of clinical anesthesia 20070801

• Ageing and leg postjunctional alpha-adrenergic vasoconstrictor responsiveness in healthy men.

  The Journal of physiology 20070701

• Ageing and vascular adrenoceptor desensitization: too little, too late?

  The Journal of physiology 20070701

• Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenopus oocytes and muscarine-induced intracellular Ca2+ elevation in cultured rat dorsal root ganglia cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20070701

• Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children.

  Paediatric anaesthesia 20070701

• Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy.

  Journal of neurosurgical anesthesiology 20070701

• Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole.

  The Veterinary record 20070630

• Effects of dexmedetomidine on the duration of anaesthesia and wakefulness in bupivacaine epidural block.

  European journal of anaesthesiology 20070601

• Does dexmedetomidine reduce the injection pain due to propofol and rocuronium?

  European journal of anaesthesiology 20070601

• Sensitive and specific liquid chromatography-tandem mass spectrometric method for the quantitation of dexmedetomidine in pediatric plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

• Dexmedetomidine as a total intravenous anesthetic in infants.

  Paediatric anaesthesia 20070601

• The effects of dexmedetomidine on myogenic motor evoked potentials in rabbits.

  Anesthesia and analgesia 20070601

• [Airway management with dexmedetomidine for difficult airway].

  Masui. The Japanese journal of anesthesiology 20070601

• Opioid consumption in total intravenous anesthesia is reduced with dexmedetomidine: a comparative study with remifentanil in gynecologic videolaparoscopic surgery.

  Journal of clinical anesthesia 20070601

• Hypothermia-induced bradycardia in a neonate receiving dexmedetomidine.

  Journal of clinical anesthesia 20070601

• Dexmedetomidine: a novel anesthetic agent for middle ear surgery.

  Recent patents on CNS drug discovery 20070601

• Effect of dexmedetomidine on bleeding during tympanoplasty or septorhinoplasty.

  European journal of anaesthesiology 20070501

• Lack in effects of therapeutic concentrations of dexmedetomidine and clonidine on the neuromuscular blocking action of rocuronium in isolated rat diaphragms.

  Anesthesia and analgesia 20070501

• Hemodynamic and respiratory changes following dexmedetomidine administration during general anesthesia: sevoflurane vs desflurane.

  Paediatric anaesthesia 20070501

• [Dexmedetomidine is a useful concomitant anesthetic agent for perioperative management during tracheobronchial Dumon stent surgery].

  Masui. The Japanese journal of anesthesiology 20070501

• Alternative to ganglionic blockade with anticholinergic and alpha-2 receptor agents.

  Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20070401

• Dexmedetomidine infusion as a supplement to isoflurane anaesthesia for vitreoretinal surgery.

  British journal of anaesthesia 20070401

• Dexmedetomidine for the treatment of postanesthesia shivering in children.

  Paediatric anaesthesia 20070401

• Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.

  British journal of anaesthesia 20070401

• Untying the Gordian knot.

  Anesthesia and analgesia 20070401

• [Effect of dexmedetomidine on hemodynamics in pediatric patients following cardiac surgery].

  Masui. The Japanese journal of anesthesiology 20070401

• Intrathecal infusion therapy with dexmedetomidine-supplemented morphine in cancer pain.

  Acta anaesthesiologica Scandinavica 20070301

• Dexmedetomidine: applications in pediatric critical care and pediatric anesthesiology.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20070301

• Adjunctive dexmedetomidine therapy in the intensive care unit: a retrospective assessment of impact on sedative and analgesic requirements, levels of sedation and analgesia, and ventilatory and hemodynamic parameters.

  Pharmacotherapy 20070301

• Dexmedetomidine for conscious sedation in difficult awake fiberoptic intubation cases.

  Journal of clinical anesthesia 20070301

• Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception.

  European journal of pharmacology 20070205

• Cardiovascular reactivity to mental stress is not affected by alpha2-adrenoreceptor activation or inhibition.

  Psychopharmacology 20070201

• Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302.

  British journal of pharmacology 20070201

• Initial experience with dexmedetomidine for diagnostic and interventional cardiac catheterization in children.

  Paediatric anaesthesia 20070201

• Loss of transcranial electric motor evoked potentials during pediatric spine surgery with dexmedetomidine.

  Anesthesiology 20070201

• Procedural sedation and analgesia research: state of the art.

  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20070201

• Dexmedetomidine: an updated review.

  The Annals of pharmacotherapy 20070201

• Autonomic activity during dexmedetomidine or fentanyl infusion with desflurane anesthesia.

  Journal of clinical anesthesia 20070201

• Assessing the depth of dexmedetomidine-induced sedation with electroencephalogram (EEG)-based spectral entropy.

  Acta anaesthesiologica Scandinavica 20070101

• Sedation and analgesia in the intensive care unit: evaluating the role of dexmedetomidine.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070101

• Dexmedetomidine sedation during awake craniotomy for seizure resection: effects on electrocorticography.

  Journal of neurosurgical anesthesiology 20070101

• The comparison of dexmedetomidine and midazolam used for sedation of patients during upper endoscopy: A prospective, randomized study.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20070101

• Alpha2-adrenoceptor agonists.

  Current opinion in investigational drugs (London, England : 2000) 20070101

• Dexmedetomidine for the treatment of paroxysmal autonomic instability with dystonia.

  Neurocritical care 20070101

• Use of dexmedetomidine in patients with trisomy 21 after cardiac surgery.

  Pediatric cardiology 20070101

• Renal function and histology after acute hemorrhage in rats under dexmedetomidine action.

  Acta cirurgica brasileira 20070101

• Effects of dexmedetomidine on respiratory mechanics and control of breathing in normal rats.

  Respiratory physiology & neurobiology 20061201

• Comparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam.

  European journal of anaesthesiology 20061201

• Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models.

  Neuroscience letters 20061201

• Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.

  British journal of pharmacology 20061201

• Prolonged use of dexmedetomidine in an infant with respiratory failure following living donor liver transplantation.

  Paediatric anaesthesia 20061201

• Using dexmedetomidine to manage patients with cocaine and opioid withdrawal, who are undergoing cerebral angioplasty for cerebral vasospasm.

  Anesthesia and analgesia 20061201

• Do the right thing (or Do the market exclusivity thing?).

  Anesthesiology 20061201

• A phase I, two-center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children.

  Anesthesiology 20061201

• [Effects of dexmedetomidine hydrochloride on postoperative sedation in cardiovascular surgery].

  Kyobu geka. The Japanese journal of thoracic surgery 20061201

• Comparison of buccal and intramuscular dexmedetomidine premedication for arthroscopic knee surgery.

  Journal of clinical anesthesia 20061201

• Cardiopulmonary effects of dexmedetomidine in goats and sheep anaesthetised with sevoflurane.

  The Veterinary record 20061104

• Dexmedetomidine as an anaesthetic adjuvant in patients undergoing intracranial tumour surgery: a double-blind, randomized and placebo-controlled study.

  British journal of anaesthesia 20061101

• The effects of pre-operative dexmedetomidine infusion on hemodynamics in patients with pulmonary hypertension undergoing mitral valve replacement surgery.

  Acta anaesthesiologica Scandinavica 20061101

• The effects of dexmedetomidine/remifentanil and midazolam/remifentanil on auditory-evoked potentials and electroencephalogram at light-to-moderate sedation levels in healthy subjects.

  Anesthesia and analgesia 20061101

• Clinical experience with dexmedetomidine for implantation of deep brain stimulators in Parkinson's disease.

  Anesthesia and analgesia 20061101

• Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects.

  Anesthesiology 20061101

• General anesthesia with dexmedetomidine in a malignant hyperthermia-susceptible woman.

  Acta anaesthesiologica Scandinavica 20061101

• Dexmedetomidine for fiberoptic intubation of a patient with severe mental retardation and atlantoaxial instability.

  Acta anaesthesiologica Scandinavica 20061101

• Clinical efficacy and safety of dexmedetomidine and buprenorphine, butorphanol or diazepam for canine hip radiography.

  The Journal of small animal practice 20061101

• Dexmedetomidine does not increase the incidence of intracarotid shunting in patients undergoing awake carotid endarterectomy.

  Anesthesia and analgesia 20061001

• Hemodynamic and anesthetic advantages of dexmedetomidine, an alpha 2-agonist, for surgery in prone position.

  The Tohoku journal of experimental medicine 20061001

• [Anesthetic management of awake coronary artery bypass grafting using dexmedetomidine--high-dose administration and pharmacokinetic simulation].

  Masui. The Japanese journal of anesthesiology 20061001

• [Validity of intraoperative administration of dexmedetomidine in a patient with dermatomyositis-derived respiratory failure].

  Masui. The Japanese journal of anesthesiology 20061001

• Perioperative uses of dexmedetomidine.

  Middle East journal of anaesthesiology 20061001

• Dexmedetomidine versus midazolam in outpatient third molar surgery.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20060901

• Ketamine and N-acetylaspartylglutamate peptidase inhibitor exert analgesia in bone cancer pain.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060901

• Dexmedetomidine infusion is associated with enhanced renal function after thoracic surgery.

  Journal of clinical anesthesia 20060901

• Tracheal resection in the morbidly obese patient: the role of dexmedetomidine.

  Journal of clinical anesthesia 20060901

• A comparison of the effect on gastric emptying of propofol or dexmedetomidine in critically ill patients: preliminary study.

  European journal of anaesthesiology 20060801

• Response entropy is more reactive than bispectral index during laparoscopic gastric banding.

  Journal of clinical monitoring and computing 20060801

• Clonidine decreases stress response in patients undergoing carotid endarterectomy under regional anesthesia: a prospective, randomized, double-blinded, placebo-controlled study.

  Anesthesia and analgesia 20060801

• Propofol acts at the sigma-1 receptor and inhibits pentazocine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices.

  Acta anaesthesiologica Scandinavica 20060801

• Dexmedetomidine-ketamine and propofol-ketamine combinations for anesthesia in spontaneously breathing pediatric patients undergoing cardiac catheterization.

  Journal of cardiothoracic and vascular anesthesia 20060801

• [Pharmacokinetic simulation of high-dose administration of dexmedetomidine for decubitus treatment].

  Masui. The Japanese journal of anesthesiology 20060801

• Opposite to alpha2-adrenergic agonists, an imidazoline I1 selective compound does not influence reflex bradycardia in rabbits.

  Autonomic neuroscience : basic & clinical 20060730

• Evaluation of the clinical efficacy and safety of dexmedetomidine or medetomidine in cats and their reversal with atipamezole.

  Veterinary anaesthesia and analgesia 20060701

• Pediatric research and scholarship: another Gordian knot?

  Anesthesia and analgesia 20060701

• The use of dexmedetomidine in pediatric cardiac surgery.

  Anesthesia and analgesia 20060701

• Dexmedetomidine for pediatric sedation for computed tomography imaging studies.

  Anesthesia and analgesia 20060701

• A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging.

  Anesthesia and analgesia 20060701

• Short duration large dose dexmedetomidine in a pediatric patient during procedural sedation.

  Anesthesia and analgesia 20060701

• Untying the Gordian knot.

  Anesthesia and analgesia 20060701

• Preliminary experience with dexmedetomidine in pediatric anesthesia.

  Anesthesia and analgesia 20060701

• Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060701

• [Dexmedetomidine].

  Masui. The Japanese journal of anesthesiology 20060701

• Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery.

  Paediatric anaesthesia 20060701

• Monitored anesthesia care with a combination of ketamine and dexmedetomidine during magnetic resonance imaging in three children with trisomy 21 and obstructive sleep apnea.

  Paediatric anaesthesia 20060701

• Safety and efficacy of dexmedetomidine in neurosurgical patients.

  Brain injury 20060701

• Benzo(alpha)pyrene-induced up-regulation of CYP1A2 gene expression: role of adrenoceptor-linked signaling pathways.

  Life sciences 20060620

• Estimation of cardiac output in a pharmacological trial using a simple method based on arterial blood pressure signal waveform: a comparison with pulmonary thermodilution and echocardiographic methods.

  European journal of clinical pharmacology 20060601

• Dexmedetomidine vs midazolam for monitored anaesthesia care during cataract surgery.

  British journal of anaesthesia 20060601

• Dexmedetomidine or medetomidine premedication before propofol-desflurane anaesthesia in dogs.

  Journal of veterinary pharmacology and therapeutics 20060601

• Addition of dexmedetomidine to standard sedation regimens after cardiac surgery: an outcomes analysis.

  Pharmacotherapy 20060601

• Propofol-induced dyskinesias controlled with dexmedetomidine during deep brain stimulation surgery.

  Anesthesiology 20060601

• The effects of esmolol and dexmedetomidine on myocardial oxygen consumption during sympathetic stimulation in dogs.

  Journal of cardiothoracic and vascular anesthesia 20060601

• A question of semantics.

  Journal of cataract and refractive surgery 20060601

• The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists.

  The Journal of pharmacology and experimental therapeutics 20060501

• Perioperative use of alpha2-adrenoceptor agonists and the cardiac patient.

  European journal of anaesthesiology 20060501

• Dexmedetomidine as rescue drug during awake craniotomy for cortical motor mapping and tumor resection.

  Anesthesia and analgesia 20060501

• Use of dexmedetomidine to facilitate extubation in surgical intensive-care-unit patients who failed previous weaning attempts following prolonged mechanical ventilation: a pilot study.

  Respiratory care 20060501

• The correlation between the Richmond agitation-sedation scale and bispectral index during dexmedetomidine sedation.

  European journal of anaesthesiology 20060401

• Dexmedetomidine facilitates withdrawal of ventilatory support.

  Anesthesiology 20060401

• Suspected malignant hyperthermia in a child with laminin alpha2 (merosin) deficiency in the absence of a triggering agent.

  Paediatric anaesthesia 20060401

• Use of dexmedetomidine in children after cardiac and thoracic surgery.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060301

• Changes in the minimum alveolar concentration of isoflurane and some cardiopulmonary measurements during three continuous infusion rates of dexmedetomidine in dogs.

  Veterinary anaesthesia and analgesia 20060301

• Dexmedetomidine for peri-operative sedation and analgesia in alcohol addiction.

  Anaesthesia 20060301

• Use of dexmedetomidine in awake craniotomy in adolescents: report of two cases.

  Paediatric anaesthesia 20060301

• A comparison of dexmedetomidine versus conventional therapy for sedation and hemodynamic control during carotid endarterectomy performed under regional anesthesia.

  Anesthesia and analgesia 20060301

• Differential effects of intravenous anesthetics on ciliary motility in cultured rat tracheal epithelial cells.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060301

• Pediatric sedation: Still a hard long way to go.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060301

• The adrenergic alpha2 receptor and sexual incentive motivation in male rats.

  Pharmacology, biochemistry, and behavior 20060301

• Dexmedetomidine and meperidine prevent postanaesthetic shivering.

  European journal of anaesthesiology 20060201

• Dexmedetomidine-induced decreases in accumbal dopamine in the rat are partly mediated via the locus coeruleus.

  Anesthesia and analgesia 20060201

• The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype.

  Anesthesia and analgesia 20060201

• Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block.

  Acta anaesthesiologica Scandinavica 20060201

• Dexmedetomidine as a sole sedating agent with local anesthesia in a high risk patient for axillofemoral bypass graft.

  AANA journal 20060201

• Fentanyl or dexmedetomidine combined with desflurane for bariatric surgery.

  Journal of clinical anesthesia 20060201

• Dexmedetomidine during local anesthesia.

  Journal of anesthesia 20060101

• [Preoperative sedation with dexmedetomidine in patients with aneurysmal subarachnoid hemorrhage].

  Masui. The Japanese journal of anesthesiology 20060101

• Cardiorespiratory and minimum alveolar concentration sparing effects of a continuous intravenous infusion of dexmedetomidine in halothane or isoflurane-anaesthetized rats.

  Laboratory animals 20060101

• [Dexmedetomidine as preventive postoperative analgesia in inguinal hernioplasty].

  Gaceta medica de Mexico 20060101

• Sedation using dexmedetomidine in pediatric burn patients.

  Journal of burn care & research : official publication of the American Burn Association 20060101

• Effect of dexmedetomidine on haemodynamic responses to laryngoscopy and intubation : perioperative haemodynamics and anaesthetic requirements.

  Drugs in R&D 20060101

• Dexmedetomidine: a novel analgesic with palliative medicine potential.

  Journal of pain & palliative care pharmacotherapy 20060101

• The effects of dexmedetomidine on spontaneous contractions of isolated gravid rat myometrium.

  Advances in therapy 20060101

• Dexmedetomidine as an adjuvant in the treatment of alcohol withdrawal delirium: a case report.

  General hospital psychiatry 20060101

• Effects of dexmedetomidine on cerebral circulation and systemic hemodynamics after cardiopulmonary resuscitation in dogs.

  Journal of anesthesia 20060101

• Repeated dexmedetomidine infusions, a postoperative living-donor liver transplantation patient.

  Journal of anesthesia 20060101

• Systemic analgesia and co-analgesia.

  Acta anaesthesiologica Belgica 20060101

• Dexmedetomidine to treat opioid withdrawal in infants following prolonged sedation in the pediatric ICU.

  Journal of opioid management 20060101

• Central apnoea after balanced general anaesthesia that included dexmedetomidine.

  British journal of anaesthesia 20051201

• Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia?

  Paediatric anaesthesia 20051201

• Alpha(1)-adrenergic and alpha(2)-adrenergic balance in the dorsal pons and gross behavioral activity of mice in a novel environment.

  Psychopharmacology 20051101

• Preliminary experience with oral dexmedetomidine for procedural and anesthetic premedication.

  Paediatric anaesthesia 20051101

• Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions.

  Anesthesiology 20051101

• Dexmedetomidine prolongs spinal anaesthesia induced by levobupivacaine 0.5% in guinea-pigs.

  The Journal of pharmacy and pharmacology 20051101

• Dexmedetomidine selectively suppresses dominant behaviour in aggressive and sociable mice.

  European journal of pharmacology 20051031

• Fiberoptic intubation with dexmedetomidine in two children with spinal cord impingements.

  Anesthesia and analgesia 20051001

• A prospective, double-blind, randomized, placebo-controlled study of dexmedetomidine as an adjunct to epidural analgesia after thoracic surgery.

  Journal of cardiothoracic and vascular anesthesia 20051001

• Dexmedetomidine as a sole sedating agent with local anesthesia in a high-risk patient for axillofemoral bypass graft: a case report.

  AANA journal 20051001

• [Effects of dexmedetomidine on intracranial hemodynamics in severe head injured patients].

  Neurocirugia (Asturias, Spain) 20051001

• Single-dose dexmedetomidine attenuates airway and circulatory reflexes during extubation.

  Acta anaesthesiologica Scandinavica 20050901

• Single-dose dexmedetomidine reduces agitation and provides smooth extubation after pediatric adenotonsillectomy.

  Paediatric anaesthesia 20050901

• Tolerance and withdrawal issues with sedation.

  Critical care nursing clinics of North America 20050901

• Long-term changes in the antinociceptive potency of morphine or dexmedetomidine after a single treatment.

  Anesthesia and analgesia 20050901

• The use of dexmedetomidine to facilitate acute discontinuation of opioids after cardiac transplantation in children.

  Critical care medicine 20050901

• Medications to provide cooperation in the critically ill pediatric patient: a rose with a thorn.

  Critical care medicine 20050901

• [Sedation of a pediatric patient using dexmedetomidine for day-care MRI].

  Masui. The Japanese journal of anesthesiology 20050901

• [Postoperative management and extubation under sedation using dexmedetomidine in a patient with old myocardial infarction after carotid endarterectomy].

  Masui. The Japanese journal of anesthesiology 20050901

• Comparison of dexmedetomidine and midazolam sedation for cataract surgery under topical anesthesia.

  Journal of cataract and refractive surgery 20050901

• Dexmedetomidine for awake craniotomy without laryngeal mask.

  Arquivos de neuro-psiquiatria 20050901

• Cardiopulmonary effects of dexmedetomidine in sevoflurane-anesthetized sheep with and without nitric oxide inhalation.

  American journal of veterinary research 20050901

• Selective alpha2-adrenergic properties of dexmedetomidine over clonidine in the human forearm.

  Journal of applied physiology (Bethesda, Md. : 1985) 20050801

• Dexmedetomidine in the treatment of cyclic vomiting syndrome.

  Paediatric anaesthesia 20050801

• Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy.

  Anesthesiology 20050801

• Dexmedetomidine facilitates the withdrawal of ventilatory support in palliative care.

  Anesthesiology 20050801

• Dexmedetomidine--does it have a role in the perioperative setting?

  Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20050801

• Prolonged infusion of dexmedetomidine for sedation following tracheal resection.

  Paediatric anaesthesia 20050701

• Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20050701

• Dexmedetomidine for neurological surgery.

  Neurosurgery 20050701

• Dexmedetomidine: promising drug for pediatric sedation?

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20050701

• Transcanal cochlear implantation under monitored anesthesia care.

  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20050701

• Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results.

  British journal of anaesthesia 20050601

• Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo.

  Pharmacogenetics and genomics 20050601

• Developmental age influences the effect of epidural dexmedetomidine on inflammatory hyperalgesia in rat pups.

  Anesthesiology 20050601

• Addition of dexmedetomidine to lidocaine for intravenous regional anaesthesia.

  European journal of anaesthesiology 20050601

• Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats.

  Anesthesia and analgesia 20050501

• Case series or uncontrolled clinical study?

  Anesthesiology 20050501

• Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction.

  Pharmacogenetics and genomics 20050501

• The prevention of pain from injection of propofol by dexmedetomidine and comparison with lidocaine.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050501

• Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog.

  Veterinary anaesthesia and analgesia 20050501

• Dexmedetomidine does not improve patient satisfaction when compared with propofol during mechanical ventilation.

  Critical care medicine 20050501

• 'If you cannot measure it, you cannot improve it'.

  Critical care medicine 20050501

• The effect of pre-anaesthetic administration of intravenous dexmedetomidine on postoperative pain in patients receiving patient-controlled morphine.

  European journal of anaesthesiology 20050501

• The in vitro effects of clonidine and dexmedetomidine on human myometrium.

  International journal of obstetric anesthesia 20050401

• Preventing pain on injection of rocuronium: two doses of dexmedetomidine.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050401

• Dexmedetomidine and awake fiberoptic intubation for possible cervical spine myelopathy: a clinical series.

  Journal of neurosurgical anesthesiology 20050401

• Rescue sedation with dexmedetomidine for diagnostic imaging: a preliminary report.

  Paediatric anaesthesia 20050301

• Dexmedetomidine as the primary sedative agent for brain radiation therapy in a 21-month old child.

  Paediatric anaesthesia 20050301

• The effects of dexmedetomidine on left ventricular function during hypoxia and reoxygenation in isolated rat hearts.

  Anesthesia and analgesia 20050301

• Dexmedetomidine decreases the convulsive potency of bupivacaine and levobupivacaine in rats: involvement of alpha2-adrenoceptor for controlling convulsions.

  Anesthesia and analgesia 20050301

• Effect of alpha2B-adrenoceptor polymorphism on peripheral vasoconstriction in healthy volunteers.

  Anesthesiology 20050301

• Synergistic and additive interactions of the cannabinoid agonist CP55,940 with mu opioid receptor and alpha2-adrenoceptor agonists in acute pain models in mice.

  British journal of pharmacology 20050301

• Dexmedetomidine in awake craniotomy: a technical note.

  Surgical neurology 20050201

• Anesthesia for a patient with morbid obesity using dexmedetomidine without narcotics.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050201

• Effects of exercise-induced stress and dexamethasone on plasma hormone and glucose concentrations and sedation in dogs treated with dexmedetomidine.

  American journal of veterinary research 20050201

• Synergy between intrathecal omega-conotoxin CVID and dexmedetomidine to attenuate mechanical hypersensitivity in the rat.

  European journal of pharmacology 20050104

• Cardiopulmonary effects and pharmacokinetics of i.v. dexmedetomidine in ponies.

  Equine veterinary journal 20050101

• Dexmedetomidine in the treatment of withdrawal syndromes in cardiothoracic surgery patients.

  Journal of intensive care medicine 20050101

• Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response.

  Pharmacogenetics and genomics 20050101

• Narcotic-based sedation regimens for critically ill mechanically ventilated patients.

  Critical care (London, England) 20050101

• Dexmedetomidine sedation in a pediatric cardiac patient scheduled for MRI.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050101

• Dexmedetomidine is a useful adjunct for awake intubation.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050101

• Use of dexmedetomidine in a pediatric heart transplant patient.

  Pediatric cardiology 20050101

• Effect of subhypnotic doses of dexmedetomidine on antitumor immunity in mice.

  Immunopharmacology and immunotoxicology 20050101

• Dexmedetomidine infusion for more than 24 hours in critically ill patients: sedative and cardiovascular effects.

  Intensive care medicine 20041201

• Dexmedetomidine for resection of a large phaeochromocytoma with invasion into the inferior vena cava.

  British journal of anaesthesia 20041201

• Cardiac arrest, a preventable yet a possible risk of dexmedetomidine: fact or fiction?

  Anesthesiology 20041201

• Dexmedetomidine and asystole.

  Anesthesiology 20041201

• Central dexmedetomidine attenuates cardiac dysfunction in a rodent model of intracranial hypertension.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20041201

• Dexmedetomidine infusion without loading dose in surgical patients requiring mechanical ventilation: haemodynamic effects and efficacy.

  Anaesthesia and intensive care 20041201

• Sedation for paediatric stereotactic radiosurgery: the dexmedetomidine experience.

  Anaesthesia and intensive care 20041201

• Comparison of the effects of dexmedetomidine and esmolol on myocardial oxygen consumption in dogs.

  European journal of anaesthesiology 20041201

• Supraclinical concentrations of dexmedetomidine evoke norepinephrine release from rat cerebrocortical slices possible involvement of the orexin-1 receptor.

  Neuroscience letters 20041130

• Altered glucose homeostasis in alpha2A-adrenoceptor knockout mice.

  European journal of pharmacology 20041128

• Dexmedetomidine and opioid interactions: defining the role of dexmedetomidine for intensive care unit sedation.

  Anesthesiology 20041101

• Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers.

  Anesthesiology 20041101

• Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers.

  Anesthesiology 20041101

• Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype.

  European journal of pharmacology 20041011

• In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens.

  Journal of neurochemistry 20041001

• Information loss over time defines the memory defect of propofol: a comparative response with thiopental and dexmedetomidine.

  Anesthesiology 20041001

• Dexmedetomidine as primary sedative in CEA patients.

  Journal of neurosurgical anesthesiology 20041001

• Enhanced visual memory effect for negative versus positive emotional content is potentiated at sub-anaesthetic concentrations of thiopental.

  British journal of anaesthesia 20040901

• Dexmedetomidine: another arrow for the clinician's quiver.

  Anesthesiology 20040901

• Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans.

  Anesthesiology 20040901

• Dexmedetomidine as a total intravenous anesthetic agent.

  Anesthesiology 20040901

• [Dexmedetomidine hydrochloride (Precedex), a new sedative in intensive care, its pharmacological characteristics and clinical study result].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040901

• Ligand-induced alpha2-adrenoceptor endocytosis: relationship to Gi protein activation.

  Biochemical and biophysical research communications 20040813

• Alpha2A-adrenoceptors are important modulators of the effects of D-amphetamine on startle reactivity and brain monoamines.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040701

• Dexmedetomidine in pediatrics: controlled studies needed.

  Paediatric anaesthesia 20040601

• The use of dexmedetomidine to facilitate opioid and benzodiazepine detoxification in an infant.

  Anesthesia and analgesia 20040601

• Dexmedetomidine in pediatrics: controlled studies needed.

  Anesthesia and analgesia 20040601

• Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats.

  Critical care medicine 20040601

• Difficult extubation: calming the sympathetic storm.

  Anaesthesia and intensive care 20040601

• Comparison of medetomidine-ketamine and dexmedetomidine-ketamine anesthesia in golden-headed lion tamarins.

  The Canadian veterinary journal = La revue veterinaire canadienne 20040601

• Dexmedetomidine overdose in the perioperative setting.

  The Annals of pharmacotherapy 20040501

• Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans.

  NeuroImage 20040501

• Sedation during mechanical ventilation in infants and children: dexmedetomidine versus midazolam.

  Southern medical journal 20040501

• Cardiovascular and parasympathetic effects of dexmedetomidine in healthy subjects.

  Canadian journal of physiology and pharmacology 20040501

• Dexmedetomidine for awake carotid endarterectomy: efficacy, hemodynamic profile, and side effects.

  Journal of neurosurgical anesthesiology 20040401

• Assessment of dexmedetomidine/ketamine anesthesia in golden-headed lion tamarins (Leontopithecus chrysomelas).

  Veterinary anaesthesia and analgesia 20040401

• Dexmedetomidine in combination with morphine PCA provides superior analgesia for shockwave lithotripsy.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20040401

• Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action.

  Anesthesiology 20040401

• Adding dexmedetomidine to lidocaine for intravenous regional anesthesia.

  Anesthesia and analgesia 20040301

• Dexmedetomidine and cardiac arrest.

  Anesthesiology 20040301

• Dexmedetomidine infusion for sedation during fiberoptic intubation: a report of three cases.

  Journal of clinical anesthesia 20040301

• [Clonidine and anesthesia].

  La Tunisie medicale 20040301

• Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040201

• Effects of the alpha2-adrenoceptor agonist dexmedetomidine on bronchoconstriction in dogs.

  Anesthesiology 20040201

• Hypothermia attenuates the vasodilator effects of dexmedetomidine on pial vessels in rabbits in vivo.

  Anesthesia and analgesia 20040201

• Stress-mediated modulation of B(alpha)P-induced hepatic CYP1A1: role of catecholamines.

  Chemico-biological interactions 20040115

• Alpha2-adrenergic receptor-induced vascular constriction in blacks and whites.

  Hypertension (Dallas, Tex. : 1979) 20040101

• Dexmedetomidine and neurocognitive testing in awake craniotomy.

  Journal of neurosurgical anesthesiology 20040101

• Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.

  Anesthesia and analgesia 20040101

• The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery.

  Anesthesia and analgesia 20040101

• Comparing dexmedetomidine prescribing patterns and safety in the naturalistic setting versus published data.

  The Annals of pharmacotherapy 20040101

• Simultaneous quantitation of dexmedetomidine and glucuronide metabolites (G-Dex-1 and G-Dex-2) in human plasma utilizing liquid chromatography with tandem mass spectrometric detection.

  Rapid communications in mass spectrometry : RCM 20040101

• Addition of dexmedetomidine prolongs duration of vasodilation induced by sympathetic block with mepivacaine in dogs.

  Regional anesthesia and pain medicine 20040101

• A new method using flow cytometry to measure the effects of drugs on gastric emptying and gastrointestinal transit in mice.

  Arzneimittel-Forschung 20040101

• Bioavailability of dexmedetomidine after extravascular doses in healthy subjects.

  British journal of clinical pharmacology 20031201

• Clinical use of dexmedetomidine as premedicant in cats undergoing propofol-sevoflurane anaesthesia.

  Journal of feline medicine and surgery 20031001

• ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens.

  Journal of cardiothoracic and vascular anesthesia 20031001

• Additional experience with dexmedetomidine in pediatric patients.

  Southern medical journal 20030901

• Constitutive precoupling to G(i) and increased agonist potency in the alpha(2B)-adrenoceptor.

  Biochemical and biophysical research communications 20030711

• Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans.

  Anesthesiology 20030701

• Measurement of the low-frequency component of blood pressure variability can assist the interpretation of heart rate variability data.

  Anesthesiology 20030701

• Awake craniotomy with dexmedetomidine in pediatric patients.

  Journal of neurosurgical anesthesiology 20030701

• Different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-A knockout mice.

  The European journal of neuroscience 20030701

• Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: a meta-analysis.

  The American journal of medicine 20030615

• Alpha2-adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the alpha2A-adrenoceptor subtype.

  Neuropharmacology 20030601

• A comparison of propofol infusion and propofol/isoflurane anaesthesia in dexmedetomidine premedicated dogs.

  Journal of veterinary pharmacology and therapeutics 20030601

• Is attenuation of extracellular dopamine increase in the nucleus accumbens the major mechanism by which dexmedetomidine increases the cocaine seizure threshold in rats?

  Anesthesiology 20030601

• The effects of dexmedetomidine and halothane on Fos expression in the spinal dorsal horn using a rat postoperative pain model.

  Neuroscience letters 20030529

• Dexmedetomidine and meperidine additively reduce the shivering threshold in humans.

  Stroke 20030501

• Agonist-dependent trafficking of alpha2-adrenoceptor subtypes: dependence on receptor subtype and employed agonist.

  European journal of cell biology 20030501

• Endogenous opioids support the spinal inhibitory action of an alpha 2-adrenoceptor agonist in the decerebrated, spinalised rabbit.

  Neuroscience letters 20030410

• Prolonged dexmedetomidine infusion as an adjunct in treating sedation-induced withdrawal.

  Anesthesia and analgesia 20030401

• Preservation of the cortical somatosensory-evoked potential during dexmedetomidine infusion in rats.

  Anesthesia and analgesia 20030401

• Development of bradycardia during sedation with dexmedetomidine in an infant concurrently receiving digoxin.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20030401

• Dexmedetomidine decreases perioperative myocardial lactate release in dogs.

  Anesthesia and analgesia 20030301

• Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats.

  Acta anaesthesiologica Scandinavica 20030301

• The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats.

  Anesthesia and analgesia 20030201

• The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects.

  Anesthesiology 20030201

• Dexmedetomidine to facilitate drug withdrawal.

  Anesthesiology 20030201

• A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit.

  Intensive care medicine 20030201

• Dexmedetomidine fails to cause hyperalgesia after cessation of chronic administration.

  Anesthesia and analgesia 20030101

• Evaluation of the sedative and cardiorespiratory effects of dexmedetomidine, dexmedetomidine-butorphanol, and dexmedetomidine-ketamine in cats.

  Journal of the American Veterinary Medical Association 20030101

• Cardiovascular reflex responses after intrathecal omega-conotoxins or dexmedetomidine in the rabbit.

  Clinical and experimental pharmacology & physiology 20030101

• Dexmedetomidine and low-dose ketamine provide adequate sedation for awake fibreoptic intubation.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20030101

• Preliminary experience with dexmedetomidine in the treatment of cyclic vomiting syndrome.

  American journal of therapeutics 20030101

• The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit.

  Journal of intensive care medicine 20030101

• Clonidine and dexmedetomidine potently inhibit peristalsis in the Guinea pig ileum in vitro.

  Anesthesiology 20021201

• Alpha 2C-adrenoceptor mediated regulation of cortical EEG arousal.

  Neuropharmacology 20021201

• [Next generation of drugs used in anesthesia].

  Masui. The Japanese journal of anesthesiology 20021201

• 24-hour Holter-monitoring in the perianaesthetic period in dogs premedicated with dexmedetomidine.

  Veterinary journal (London, England : 1997) 20021101

• Dexmedetomidine-induced sedation in volunteers decreases regional and global cerebral blood flow.

  Anesthesia and analgesia 20021001

• [Preliminary experience with dexmedetomidine treatment of confusional state and hyperadrenergic states at an intensive care unit].

  Revista espanola de anestesiologia y reanimacion 20021001

• [Dexmedetomidine, a promising drug].

  Revista espanola de anestesiologia y reanimacion 20021001

• New concepts in intensive care: dexmedetomidine and immunonutrition.

  Middle East journal of anaesthesiology 20021001

• Dexmedetomidine: a novel drug for sedation and analgesia in the ICU.

  Middle East journal of anaesthesiology 20021001

• Dexmedetomidine: a sedative-analgesic drug for the 21st century.

  Middle East journal of anaesthesiology 20021001

• Dexmedetomidine in intensive care unit: a study of hemodynamic changes.

  Middle East journal of anaesthesiology 20021001

• Phase III study on dexmedetomidine used for postoperative sedation of patients requiring mechanical ventilation for less than 24 hours: the French experience.

  Middle East journal of anaesthesiology 20021001

• Autonomic nervous system responses during sedative infusions of dexmedetomidine.

  Anesthesiology 20020901

• Dexmedetomidine increases the cocaine seizure threshold in rats.

  Anesthesiology 20020901

• Treatment of persistent tachycardia with dexmedetomidine during off-pump cardiac surgery.

  Anesthesia and analgesia 20020801

• The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation.

  Anesthesia and analgesia 20020801

• Effect of synthesis parameters of the sol-gel-processed spray-dried silica gel microparticles on the release rate of dexmedetomidine.

  Biomaterials 20020701

• The effects of dexmedetomidine on the ventilatory response to hypercapnia in rabbits.

  Intensive care medicine 20020701

• Dexmedetomidine may impair cognitive testing during endovascular embolization of cerebral arteriovenous malformations: a retrospective case report series.

  Journal of neurosurgical anesthesiology 20020701

• Dexmedetomidine: a new option for intractable distress in the dying.

  Journal of pain and symptom management 20020701

• Dual alpha(2)-adrenergic agonist and alpha(1)-adrenergic antagonist actions of dexmedetomidine on human isolated endothelium-denuded gastroepiploic arteries.

  Anesthesia and analgesia 20020601

• In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse prefrontal cortex.

  The European journal of neuroscience 20020601

• Bispectral index-guided sedation with dexmedetomidine in intensive care: a prospective, randomized, double blind, placebo-controlled phase II study.

  Critical care medicine 20020501

• New agents, new monitors, same unanswered questions.

  Critical care medicine 20020501

• Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive caret.

  British journal of anaesthesia 20020501

• Dexmedetomidine may be effective, but is it safe?

  British journal of anaesthesia 20020301

• Effect of the alpha2-agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats.

  Anesthesiology 20020201

• The use of alpha2-agonists during off-pump coronary artery bypass and the effects of hypothermia.

  Journal of cardiothoracic and vascular anesthesia 20020201

• Initial experience with dexmedetomidine in paediatric-aged patients.

  Paediatric anaesthesia 20020201

• Effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury: comparison of clonidine and dexmedetomidine.

  Anesthesiology 20020101

• Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems.

  Neuroscience 20020101

• The role of mu-opioid receptors in inflammatory hyperalgesia and alpha 2-adrenoceptor-mediated antihyperalgesia.

  Neuroscience 20020101

• Dexmedetomidine decreases extracellular dopamine concentrations in the rat nucleus accumbens.

  Brain research 20011116

• Spatial working memory improvement by an alpha2-adrenoceptor agonist dexmedetomidine is not mediated through alpha2C-adrenoceptor.

  Progress in neuro-psychopharmacology & biological psychiatry 20011101

• The pharmacokinetics of dexmedetomidine in volunteers with severe renal impairment.

  Anesthesia and analgesia 20011101

• Dexmedetomidine: a real innovation or more of the same?

  British journal of anaesthesia 20011101

• Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions.

  British journal of anaesthesia 20011101

• Alkyl-substituted silica gel as a carrier in the controlled release of dexmedetomidine.

  Journal of controlled release : official journal of the Controlled Release Society 20011019

• The synergistic antinociceptive interactions of endomorphin-1 with dexmedetomidine and/or S(+)-ketamine in rats.

  Anesthesia and analgesia 20011001

• Clinical comparison of preanaesthetic intramuscular medetomidine and dexmedetomidine in domestic sheep.

  DTW. Deutsche tierarztliche Wochenschrift 20011001

• Dexmedetomidine infusion and somatosensory evoked potentials.

  Journal of neurosurgical anesthesiology 20011001

• Use of propofol and other nonbenzodiazepine sedatives in the intensive care unit.

  Critical care clinics 20011001

• New agents for sedation in the intensive care unit.

  Critical care clinics 20011001

• Noradrenergic modulation of serotonin release in rat dorsal and median raphé nuclei via alpha(1) and alpha(2A) adrenoceptors.

  Neuropharmacology 20010901

• Dexmedetomidine.

  Current opinion in critical care 20010801

• Dextromethorphan and dexmedetomidine: new agents for the control of perioperative pain.

  The European journal of surgery = Acta chirurgica 20010801

• Comparison of medetomidine and dexmedetomidine as premedicants in dogs undergoing propofol-isoflurane anesthesia.

  American journal of veterinary research 20010701

• Sedative but not analgesic alpha2 agonist tolerance is blocked by NMDA receptor and nitric oxide synthase inhibitors.

  Anesthesiology 20010701

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  International journal of pharmaceutics 20010619

• The use of dexmedetomidine infusion for awake craniotomy.

  Anesthesia and analgesia 20010501

• The effect of intravenous dexmedetomidine premedication on the dose requirement of propofol to induce loss of consciousness in patients receiving alfentanil.

  Anaesthesia 20010501

• Dexmedetomidine, a novel alpha 2-adrenergic agonist for short-term sedation in the intensive care unit.

  Connecticut medicine 20010501

• Comparison of medetomidine and dexmedetomidine as premedication in isoflurane anaesthesia for orthopaedic surgery in domestic sheep.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20010501

• Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit.

  British journal of anaesthesia 20010501

• Evaluation of the alpha2C-adrenoceptor as a neuropsychiatric drug target studies in transgenic mouse models.

  Life sciences 20010406

• Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: characterization of alpha2-adrenoceptor.

  Neurochemistry international 20010401

• Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine.

  British journal of pharmacology 20010401

• Sedative, analgesic, and cardiovascular effects of levomedetomidine alone and in combination with dexmedetomidine in dogs.

  American journal of veterinary research 20010401

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  Zentralblatt fur Chirurgie 20010401

• Effect of dexmedetomidine on propofol requirements in healthy subjects.

  Journal of pharmaceutical sciences 20010201

• Effect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia.

  British journal of clinical pharmacology 20010101

• Effects of dexmedetomidine after transient and permanent occlusion of the middle cerebral artery in the rat.

  Journal of neural transmission (Vienna, Austria : 1996) 20010101

• Noradrenergic regulation of hippocampal place cells.

  Hippocampus 20010101

• Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors.

  British journal of pharmacology 20000401

• Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit.

  Anaesthesia 19991201