145733-36-4 | Tasosartan

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$164.00	$115.00
50mg	98%	in stock	$214.00	$150.00

Description

• Catalog Number: AA63784
• Chemical Name: Tasosartan
• CAS Number: 145733-36-4
• Molecular Formula: C23H21N7O
• Molecular Weight: 411.4591
• MDL Number: MFCD00865905
• SMILES: Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2

Computed Properties

• Complexity: 625
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 3

Literature

• Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

  Chemical research in toxicology 20170515

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.

  Bioorganic & medicinal chemistry 20101215

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists.

  Journal of medicinal chemistry 20050630

• Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.

  Journal of medicinal chemistry 20030605

• Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects.

  Bioorganic & medicinal chemistry letters 20020805

• Pharmacology of AT1-receptor blockers.

  Blood pressure. Supplement 20010101

• Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding.

  The Journal of pharmacology and experimental therapeutics 20001101

• Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.

  Journal of medicinal chemistry 19960202