145821-59-6 | Tiagabine hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$31.00	$22.00
5mg	99%	in stock	$34.00	$24.00
25mg	99%	in stock	$63.00	$45.00
50mg	99%	in stock	$111.00	$78.00
100mg	99%	in stock	$186.00	$130.00
250mg	99%	in stock	$279.00	$195.00

Description

• Catalog Number: AA63874
• Chemical Name: Tiagabine hydrochloride
• CAS Number: 145821-59-6
• Molecular Formula: C20H26ClNO2S2
• Molecular Weight: 412.0089
• MDL Number: MFCD07369025
• SMILES: OC(=O)[C@@H]1CCCN(C1)CCC=C(c1sccc1C)c1sccc1C.Cl

Computed Properties

• Complexity: 474
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6

Literature

• Chronic tiagabine administration and aggressive responding in individuals with a history of substance abuse and antisocial behavior.

  Journal of psychopharmacology (Oxford, England) 20120701

• Separate and combined effects of the GABA reuptake inhibitor tiagabine and Δ9-THC in humans discriminating Δ9-THC.

  Drug and alcohol dependence 20120401

• Identification of tiagabine degradation products using liquid chromatography with electrospray ionization multistage mass spectrometry and ultra-performance liquid chromatography/high-resolution mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20120215

• Combinational spinal GAD65 gene delivery and systemic GABA-mimetic treatment for modulation of spasticity.

  PloS one 20120101

• [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels.

  PloS one 20120101

• Tiagabine add-on for drug-resistant partial epilepsy.

  The Cochrane database of systematic reviews 20120101

• A steered molecular dynamics study of binding and translocation processes in the GABA transporter.

  PloS one 20120101

• Tiagabine in the maintenance treatment of bipolar disorder.

  The Cochrane database of systematic reviews 20111207

• Blockade of GABA(B) receptors facilitates evoked neurotransmitter release at spinal dorsal horn synapse.

  Neuroscience 20111013

• Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol.

  The Journal of pharmacology and experimental therapeutics 20110701

• Analyte and internal standard cross signal contributions and their impact on quantitation in LC-MS based bioanalysis.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110701

• Clinical comparability of the new antiepileptic drugs in refractory partial epilepsy: a systematic review and meta-analysis.

  Epilepsia 20110701

• Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice.

  Epilepsy research 20110601

• An historical perspective on GABAergic drugs.

  Future medicinal chemistry 20110201

• An open pilot study of tiagabine in alcohol dependence: tolerability and clinical effects.

  Journal of psychopharmacology (Oxford, England) 20100901

• A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures.

  Neurochemical research 20100901

• A convergent approach to (R)-Tiagabine by a regio- and stereocontrolled hydroiodination of alkynes.

  Organic & biomolecular chemistry 20100807

• Intrinsic activation of GABA(A) receptors suppresses epileptiform activity in the cerebral cortex of immature mice.

  Epilepsia 20100801

• Homology modelling of the GABA transporter and analysis of tiagabine binding.

  ChemMedChem 20100705

• Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice.

  Journal of psychopharmacology (Oxford, England) 20100501

• Loss of GABAergic interneurons in laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain after spinal cord injury.

  Journal of neurotrauma 20100401

• Emergent complications of the newer anticonvulsants.

  The Journal of emergency medicine 20100201

• Behavioral and cognitive effects of anti-epileptic drugs.

  Discovery medicine 20100201

• [Therapeutic drug monitoring of tiagabine].

  Therapie 20100101

• Changes in CCK-4 induced panic after treatment with the GABA-reuptake inhibitor tiagabine are associated with an increase in 3alpha,5alpha-tetrahydrodeoxycorticosterone concentrations.

  Psychoneuroendocrinology 20091101

• Effects of the GABA-reuptake inhibitor tiagabine on panic and anxiety in patients with panic disorder.

  Pharmacopsychiatry 20091101

• Synergistic interaction of gabapentin with tiagabine in the formalin test in mice: an isobolographic analysis.

  European journal of pain (London, England) 20090801

• Questionable tolerability of tiagabine in generalized anxiety disorder.

  Journal of clinical psychopharmacology 20090601

• Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs.

  Journal of neurochemistry 20090501

• Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.

  European journal of pharmacology 20090301

• Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090201

• For publication: Tiagabine in the discontinuation of long-term benzodiazepine use.

  Psychiatry and clinical neurosciences 20090201

• Increase in tiagabine serum concentration with coadministration of gemfibrozil.

  The Annals of pharmacotherapy 20090201

• A PET study of tiagabine treatment implicates ventral medial prefrontal cortex in generalized social anxiety disorder.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090101

• Retention rates of new antiepileptic drugs in localization-related epilepsy: a single-center study.

  Acta neurologica Scandinavica 20090101

• Tiagabine augmentation to fluvoxamine-risperidone combination in the treatment of obsessive-compulsive disorder.

  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20090101

• Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.

  Advances in medical sciences 20090101

• Synergistic interaction of gabapentin with tiagabine in the hot-plate test in mice: an isobolographic analysis.

  Pharmacological reports : PR 20090101

• Effect of caffeine on the anticonvulsant effects of oxcarbazepine, lamotrigine and tiagabine in a mouse model of generalized tonic-clonic seizures.

  Pharmacological reports : PR 20090101

• Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.

  Naunyn-Schmiedeberg's archives of pharmacology 20081101

• Tiagabine for essential tremor: an open-label trial.

  Movement disorders : official journal of the Movement Disorder Society 20081015

• Metabolism of [1,6-(13)C]glucose and [U-(13)C]glutamine and depolarization induced GABA release in superfused mouse cerebral cortical mini-slices.

  Neurochemical research 20080801

• Tiagabine: let seizing dogs lie?

  Emergency medicine Australasia : EMA 20080801

• Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease.

  Neurobiology of disease 20080601

• Tiagabine in adult patients with generalized anxiety disorder: results from 3 randomized, double-blind, placebo-controlled, parallel-group studies.

  Journal of clinical psychopharmacology 20080601

• Interactions between tiagabine and conventional antiepileptic drugs in the rat model of complex partial seizures.

  Journal of neural transmission (Vienna, Austria : 1996) 20080501

• Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats.

  Psychopharmacology 20080501

• Seizure-freedom with combination therapy in localization-related epilepsy.

  Seizure 20080401

• Tiagabine, a GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats.

  Progress in neuro-psychopharmacology & biological psychiatry 20080401

• Effects of acute tiagabine administration on aggressive responses of adult male parolees.

  Journal of psychopharmacology (Oxford, England) 20080301

• Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC).

  Epilepsy research 20080301

• Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression.

  Pharmacopsychiatry 20080301

• Hypoalgesia in mice lacking GABA transporter subtype 1.

  Journal of neuroscience research 20080201

• Status epilepticus due to tiagabine ingestion.

  American journal of therapeutics 20080101

• Pilot study of lorazepam and tiagabine effects on sleep, motor learning, and impulsivity in cocaine abstinence.

  The American journal of drug and alcohol abuse 20080101

• GABI-balance--a non-interventional observational study on the effectiveness of tiagabine in add-on therapy in partial epilepsy.

  Neurologia i neurochirurgia polska 20080101

• Effect of cocaine on responsiveness of alpha(1)-adrenergic receptors in rat cerebral cortex: modulation by GABA-mimetic drugs.

  Pharmacological reports : PR 20080101

• [Treatment of epilepsy with third-line antiepileptic drugs: felbamate, tiagabine, and sulthiame].

  Der Nervenarzt 20071201

• A double-blind, placebo-controlled trial of tiagabine for the treatment of cocaine dependence.

  Drug and alcohol dependence 20071201

• Deliberate self-poisoning with tiagabine: an unusual toxidrome.

  Emergency medicine Australasia : EMA 20071201

• Tiagabine and exacerbation of essential tremor.

  Movement disorders : official journal of the Movement Disorder Society 20071031

• Neurochemical regulation of sleep.

  Journal of psychiatric research 20071001

• Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1.

  Biochemical and biophysical research communications 20070921

• Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons.

  Drug and alcohol dependence 20070710

• Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors.

  Bioorganic & medicinal chemistry letters 20070701

• Tiagabine for social anxiety disorder.

  Human psychopharmacology 20070601

• Diverse effects of GABA-mimetic drugs on cocaine-evoked self-administration and discriminative stimulus effects in rats.

  Psychopharmacology 20070501

• Tiagabine does not attenuate alcohol-induced activation of the human reward system.

  Psychopharmacology 20070501

• Absence seizures are reduced by the enhancement of GABA-ergic inhibition in the hippocampus in WAG/Rij rats.

  Neuroscience letters 20070406

• New therapies for ataxia-telangiectasia.

  Archives of neurology 20070401

• Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy.

  Progress in neuro-psychopharmacology & biological psychiatry 20070330

• Anticonvulsants in sports: ethical considerations.

  Epilepsy & behavior : E&B 20070301

• Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients.

  Drug and alcohol dependence 20070223

• The efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder.

  Journal of clinical psychopharmacology 20070201

• Tiagabine-induced myoclonic status epilepticus in a nonepileptic patient.

  Neurology 20070123

• Novel anticonvulsant drugs.

  Pharmacology & therapeutics 20070101

• High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study.

  Neurochemistry international 20070101

• An open-label study to evaluate switching from an SSRI or SNRI to tiagabine to alleviate antidepressant-induced sexual dysfunction in generalized anxiety disorder.

  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20070101

• Influence of tiagabine on the antinociceptive action of morphine, metamizole and indomethacin in mice.

  Acta poloniae pharmaceutica 20070101

• [Tiagabine overdose--report of two cases].

  Przeglad lekarski 20070101

• Is tiagabine helpful in generalized anxiety disorder?

  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20070101

• Effect of NG-nitro-L-arginine on the anticonvulsant action of four second-generation antiepileptic drugs in pentetrazole-induced clonic seizures in mice.

  Pharmacological reports : PR 20070101

• An open-label study of tiagabine in panic disorder.

  Psychopharmacology bulletin 20070101

• [Caffeine and antiepileptic drugs: experimental and clinical data].

  Przeglad lekarski 20070101

• Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice.

  Inflammopharmacology 20061201

• Seizures in a pediatric patient with a tiagabine overdose.

  Journal of medical toxicology : official journal of the American College of Medical Toxicology 20061201

• Tiagabine-induced nonconvulsive status epilepticus in an adolescent without epilepsy.

  Neurology 20061024

• [Adult-onset ataxia-telangiectasia. A clinical and therapeutic observation].

  Neurologia (Barcelona, Spain) 20061001

• Tiagabine in anxiety disorders.

  Expert opinion on pharmacotherapy 20061001

• Effect of the administration of tiagabine and gabapentin on rabbit electroencephalogram activity.

  The Journal of pharmacy and pharmacology 20061001

• Altered cortico-striatal synaptic plasticity and related behavioural impairments in reeler mice.

  The European journal of neuroscience 20061001

• Tiagabine withdrawal-emergent mania.

  The Australian and New Zealand journal of psychiatry 20060801

• Tiagabine in the treatment of acute affective episodes in bipolar disorder: efficacy and acceptability.

  The Cochrane database of systematic reviews 20060719

• Tiagabine in the maintenance treatment of bipolar disorders.

  The Cochrane database of systematic reviews 20060719

• Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization.

  European journal of pharmacology 20060717

• Comparison of the cognitive effects of tiagabine and carbamazepine as monotherapy in newly diagnosed adult patients with partial epilepsy: pooled analysis of two long-term, randomized, follow-up studies.

  Epilepsia 20060701

• Tiagabine and vigabatrin reduce the severity of NMDA-induced excitotoxicity in chick retina.

  Experimental brain research 20060601

• Long-term effects of tiagabine monotherapy on cognition and mood in adult patients with chronic partial epilepsy.

  Epilepsy & behavior : E&B 20060601

• The use of tiagabine in pediatric spasticity management.

  Developmental medicine and child neurology 20060601

• Age-correlated decline in [3H]tiagabine binding to GAT-1 in human frontal cortex.

  Aging clinical and experimental research 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Pregabalin exerts oppositional effects on different inhibitory circuits in human motor cortex: a double-blind, placebo-controlled transcranial magnetic stimulation study.

  Epilepsia 20060501

• Transient athetosis induced by tiagabine.

  Epilepsia 20060401

• Tiagabine is associated with sustained attention during sleep restriction: evidence for the value of slow-wave sleep enhancement?

  Sleep 20060401

• Tiagabine enhances slow wave sleep and sleep maintenance in primary insomnia.

  Sleep medicine 20060301

• Emerging pharmacological strategies in the fight against cocaine addiction.

  Expert opinion on emerging drugs 20060301

• Effect of tiagabine on sleep in elderly subjects with primary insomnia: a randomized, double-blind, placebo-controlled study.

  Sleep 20060301

• Seizure activity and off-label use of tiagabine.

  The New England journal of medicine 20060216

• Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomnia.

  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20060115

• Design, synthesis, and biological evaluation of the N-diarylalkenyl-piperidinecarboxylic acid derivatives as GABA uptake inhibitors (I).

  Bioorganic & medicinal chemistry letters 20060101

• Tiagabine for posttraumatic stress disorder: effects of open-label and double-blind discontinuation treatment.

  Psychopharmacology 20060101

• Open-label tiagabine monotherapy for major depressive disorder with anxiety.

  The Journal of clinical psychiatry 20060101

• Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed?

  Clinical pharmacokinetics 20060101

• Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors.

  Advances in pharmacology (San Diego, Calif.) 20060101

• Effect of combined administration of ethanol and tiagabine on rabbit EEG.

  Pharmacological reports : PR 20060101

• Effects of GABAergic modulators on food and cocaine self-administration in baboons.

  Drug and alcohol dependence 20051212

• Color vision and contrast sensitivity in epilepsy patients treated with initial tiagabine monotherapy.

  Epilepsy research 20051201

• A retrospective chart review comparing tiagabine and benzodiazepines for the treatment of alcohol withdrawal.

  Journal of psychoactive drugs 20051201

• Tiagabine affects the subjective responses to cocaine in humans.

  Pharmacology, biochemistry, and behavior 20051101

• The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study.

  The Journal of clinical psychiatry 20051101

• Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant.

  European journal of pharmacology 20051003

• Status epilepticus and tiagabine therapy revisited.

  Epilepsia 20051001

• Recent pharmacologic updates.

  Journal of child and adolescent psychopharmacology 20051001

• Effects of tiagabine in combination with intravenous nicotine in overnight abstinent smokers.

  Psychopharmacology 20050901

• Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.

  Naunyn-Schmiedeberg's archives of pharmacology 20050701

• Tiagabine reduces ethanol reward in C57BL/6 mice under acute and chronic administration regimens.

  Synapse (New York, N.Y.) 20050601

• Dose-response effects of tiagabine on the sleep of older adults.

  Sleep 20050601

• Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy.

  Epilepsy & behavior : E&B 20050501

• Tiagabine as add-on therapy may be more effective with valproic acid--open label, multicentre study of patients with focal epilepsy.

  European journal of neurology 20050301

• A randomised open-label study of tiagabine given two or three times daily in refractory epilepsy.

  Seizure 20050301

• A placebo-controlled screening trial of tiagabine, sertraline and donepezil as cocaine dependence treatments.

  Addiction (Abingdon, England) 20050301

• Cocaine Rapid Efficacy Screening Trial (CREST): a paradigm for the controlled evaluation of candidate medications for cocaine dependence.

  Addiction (Abingdon, England) 20050301

• First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.

  The Journal of pharmacology and experimental therapeutics 20050201

• Tiagabine-induced generalised non convulsive status epilepticus in patients with lesional focal epilepsy.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20050201

• Trauma, resilience and saliostasis: effects of treatment in post-traumatic stress disorder.

  International clinical psychopharmacology 20050101

• Antiepileptic action induced by a combination of vigabatrin and tiagabine.

  Neuroscience 20050101

• Tiagabine for rage, aggression, and anxiety.

  The Journal of neuropsychiatry and clinical neurosciences 20050101

• Tiagabine and gabapentin for the management of chronic pain.

  The Clinical journal of pain 20050101

• Saccadic eye velocity after selective GABAergic treatment with tiagabine in healthy volunteers.

  Neuropsychobiology 20050101

• Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats.

  Epilepsy research 20050101

• Tiagabine may reduce bruxism and associated temporomandibular joint pain.

  Anesthesia progress 20050101

• Depression of extra-cellular GABA and increase of NMDA-induced nitric oxide following acute intra-nuclear administration of alcohol in the cerebellar nuclei of the rat.

  Cerebellum (London, England) 20050101

• [GEOS (Gabitril Epilepsy Observational Study) -- Polish results of the international study of tiagabine in partial epilepsy].

  Neurologia i neurochirurgia polska 20050101

• Role of opioidergic mechanisms and GABA uptake inhibition in the heroin-induced discriminative stimulus effects in rats.

  Pharmacological reports : PR 20050101

• An open-label study of tiagabine as augmentation therapy for anxiety.

  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20050101

• Retrospective evaluation of tiagabine overdose.

  Clinical toxicology (Philadelphia, Pa.) 20050101

• Tiagabine overdose: a case of status epilepticus in a non-epileptic patient.

  Clinical toxicology (Philadelphia, Pa.) 20050101

• The pharmacokinetic inter-relationship of tiagabine in blood, cerebrospinal fluid and brain extracellular fluid (frontal cortex and hippocampus).

  Seizure 20041201

• GABA transporters as drug targets for modulation of GABAergic activity.

  Biochemical pharmacology 20041015

• Acute administration of the GABA reuptake inhibitor tiagabine does not alter the effects of oral cocaine in humans.

  Drug and alcohol dependence 20041005

• Intentional overdose with tiagabine: an unusual clinical presentation.

  The Journal of emergency medicine 20041001

• Behavioural correlates of an altered balance between synaptic and extrasynaptic GABAAergic inhibition in a mouse model.

  The European journal of neuroscience 20041001

• [Progressive encephalomyelitis with rigidity responsive to gabapentin: a pharmacological update].

  Neurologia (Barcelona, Spain) 20041001

• Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA.

  Epilepsia 20040901

• Vigabatrin and tiagabine might have antipanic properties.

  Journal of psychopharmacology (Oxford, England) 20040901

• New pharmacotherapies for pediatric seizures.

  Pediatric annals 20040601

• Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.

  Epilepsia 20040501

• Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.

  Epilepsia 20040501

• Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat.

  Epilepsia 20040501

• Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society.

  Neurology 20040427

• Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study.

  Naunyn-Schmiedeberg's archives of pharmacology 20040401

• Interaction between anticonvulsants and human placental carnitine transporter.

  Epilepsia 20040301

• Anticonvulsants as anxiolytics, part 1: tiagabine and other anticonvulsants with actions on GABA.

  The Journal of clinical psychiatry 20040301

• The new antiepileptic drugs: scientific review.

  JAMA 20040204

• Coactivation of GABA(A) and GABA(B) receptor results in neuroprotection during in vitro ischemia.

  Stroke 20040201

• Tiagabine for treating painful tonic spasms in multiple sclerosis: a pilot study.

  Journal of neurology, neurosurgery, and psychiatry 20040201

• GABA-B receptor activation in the rat globus pallidus potently suppresses pentylenetetrazol-induced tonic seizures.

  Journal of biomedical science 20040101

• Newer anticonvulsants in the treatment of bipolar disorder.

  The Journal of clinical psychiatry 20040101

• Antiepileptic drugs in migraine prophylaxis: state of the art.

  La Clinica terapeutica 20040101

• [New molecular targets in pharmacological treatment of anxiety disorders].

  Vertex (Buenos Aires, Argentina) 20040101

• Low-dose tiagabine effectiveness in anxiety disorders.

  MedGenMed : Medscape general medicine 20040101

• Non-convulsive status epilepticus associated with tiagabine therapy in children.

  Seizure 20031201

• Tiagabine for posttraumatic stress disorder: a case series of 7 women.

  The Journal of clinical psychiatry 20031201

• Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study.

  Addiction (Abingdon, England) 20031101

• Tiagabine synergistically interacts with gabapentin in the electroconvulsive threshold test in mice.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031001

• Non-convulsive status epilepticus associated with tiagabine in a pediatric patient.

  Brain & development 20031001

• [Clinical and neurochemical aspects of diaphragmatic myoclonus].

  Neurologia (Barcelona, Spain) 20031001

• Tiagabine for the treatment of generalized anxiety disorder: a randomized, open-label, clinical trial with paroxetine as a positive control.

  The Journal of clinical psychiatry 20031001

• Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus.

  Experimental brain research 20030901

• Nonconvulsive status epilepticus due to a de novo contralateral focus during tiagabine adjunctive therapy.

  Seizure 20030701

• [Significance of GABAA receptors for the pathophysiology and therapy of panic disorders].

  Der Nervenarzt 20030701

• Clinical and EEG findings in six patients with altered mental status receiving tiagabine therapy.

  Epilepsy & behavior : E&B 20030601

• Interactions of tiagabine with some antiepileptics in the maximal electroshock in mice.

  Pharmacology, biochemistry, and behavior 20030501

• The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?

  Epileptic disorders : international epilepsy journal with videotape 20030501

• Altered gene expression in frontal cortex and midbrain of 3,4-methylenedioxymethamphetamine (MDMA) treated mice: differential regulation of GABA transporter subtypes.

  Journal of neuroscience research 20030415

• Vigabatrin, tiagabine, and visual fields.

  Journal of neurology, neurosurgery, and psychiatry 20030301

• A controlled study comparing visual function in patients treated with vigabatrin and tiagabine.

  Journal of neurology, neurosurgery, and psychiatry 20030301

• Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction.

  Epilepsia 20030301

• Treating bipolar depression.

  The Journal of family practice 20030301

• Pre-clinical studies with the GABAergic compounds vigabatrin and tiagabine.

  Epileptic disorders : international epilepsy journal with videotape 20030301

• Novel mechanisms of action of three antiepileptic drugs, vigabatrin, tiagabine, and topiramate.

  Neurochemical research 20030201

• Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.

  Neuroscience letters 20030102

• Stability of tiagabine in two oral liquid vehicles.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030101

• Unaltered control of extracellular GABA-concentration through GAT-1 in the hippocampus of rats after pilocarpine-induced status epilepticus.

  Epilepsy research 20030101

• The role of GABA in anxiety disorders.

  The Journal of clinical psychiatry 20030101

• Tiagabine for the treatment of anxiety.

  Depression and anxiety 20030101

• [Determinants of tiagabine (TGB) efficacy and safety. A Polish multicenter study of 1307 patients with focal epilepsy].

  Neurologia i neurochirurgia polska 20030101

• Effects of tiagabine on cholecystokinin-tetrapeptide (CCK-4)-induced anxiety in healthy volunteers.

  Depression and anxiety 20030101

• Pre- rather than co-application of vigabatrin increases the efficacy of tiagabine in hippocampal slices.

  Epilepsia 20021201

• Antiepileptic drug therapy for adults: when to initiate and how to choose.

  Mayo Clinic proceedings 20021201

• Tolerability of tiagabine: a prospective open-label study.

  Epileptic disorders : international epilepsy journal with videotape 20021201

• New antiepileptic drug therapies.

  Neurologic clinics 20021101

• Treatment of posttraumatic stress disorder with tiagabine.

  Canadian journal of psychiatry. Revue canadienne de psychiatrie 20021001

• Tiagabine in treatment refractory bipolar disorder: a clinical case series.

  Bipolar disorders 20021001

• [(3)H]Tiagabine binding to GABA transporter-1 (GAT-1) in suicidal depression.

  Journal of affective disorders 20020901

• An open case series on the utility of tiagabine as an augmentation in refractory bipolar outpatients.

  Journal of affective disorders 20020901

• Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception.

  The Journal of pharmacology and experimental therapeutics 20020901

• [Characteristics and indications of tiagabine].

  Revista de neurologia 20020901

• Selective suppression of hippocampal region hyperexcitability related to seizure susceptibility in epileptic El mice by the GABA-transporter inhibitor tiagabine.

  Brain research 20020830

• Neuroprotective effect of tiagabine in transient forebrain global ischemia: an in vivo microdialysis, behavioral, and histological study.

  Brain research 20020816

• Tiagabine, a gamma-amino-butyric acid transporter inhibitor impairs spatial learning of rats in the Morris water-maze.

  Behavioural brain research 20020718

• Aggravation of partial seizures by antiepileptic drugs: is there evidence from clinical trials?

  Neurology 20020709

• Tiagabine overdose can induce convulsive status epilepticus.

  Epilepsia 20020701

• Tiagabine-related non-convulsive status epilepticus in partial epilepsy: three case reports and a review of the literature.

  Seizure 20020601

• Effects of tiagabine, a gamma-aminobutyric acid re-uptake inhibitor, on normal rat bladder function.

  The Journal of urology 20020501

• Contribution of GABAergic cortical circuitry in shaping somatosensory evoked scalp responses: specific changes after single-dose administration of tiagabine.

  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20020501

• Anxiolytic-like effects of acute and chronic GABA transporter inhibition in rats.

  Journal of neural transmission (Vienna, Austria : 1996) 20020501

• Occurrence of psychosis in patients with epilepsy randomized to tiagabine or placebo treatment.

  Epilepsia 20020401

• Free-choice ethanol consumption under the influence of GABAergic drugs in rats.

  Alcoholism, clinical and experimental research 20020401

• Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendations.

  The Journal of clinical psychiatry 20020401

• The 'number needed to treat' with levetiracetam (LEV): comparison with the other new antiepileptic drugs (AEDs).

  Seizure 20020401

• [Adult GM2 gangliosidosis: improvement of ataxia with GABAergic drugs].

  Neurologia (Barcelona, Spain) 20020301

• Visual field defects.

  Seizure 20020301

• Tiagabine in glial tumors.

  Epilepsy research 20020301

• Recurrent complex partial status epilepticus associated with tiagabine rechallenge.

  Acta neurologica Belgica 20020301

• Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1.

  British journal of pharmacology 20020101

• Increased [(3)H]tiagabine binding to GAT-1 in the cingulate cortex in schizophrenia.

  Neuropsychobiology 20020101

• The use of tiagabine in affective disorders.

  Pharmacopsychiatry 20020101

• Non-convulsive status epilepticus induced by tiagabine in a patient with pseudoseizure.

  Seizure 20020101

• Effects of tiagabine and diazepam on operant ethanol self-administration in the rat.

  Journal of studies on alcohol 20020101

• Tiagabine add-on for drug-resistant partial epilepsy.

  The Cochrane database of systematic reviews 20020101

• The use of tiagabine augmentation for treatment-resistant anxiety disorders: a case series.

  Psychopharmacology bulletin 20020101

• Effectiveness of adjunctive therapy with tiagabine in mentally disabled patients with epilepsy.

  Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20020101

• Treatment of painful sensory neuropathy with tiagabine: a pilot study.

  Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20011201

• [Monitoring of renal function in epileptic children and teenagers treated with valproic acid or carbamazepine in concomitant therapy with tiagabine].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20011201

• [Experience with tiagabine in the clinical practice; new insights as to the efficacy and safety profile].

  Der Nervenarzt 20011001

• Visual fields and tiagabine: a quandary.

  Seizure 20011001

• Drug-induced nonconvulsive status epilepticus with low dose of tiagabine.

  Epileptic disorders : international epilepsy journal with videotape 20010901

• Tiagabine improves panic and agoraphobia in panic disorder patients.

  The Journal of clinical psychiatry 20010801

• Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina.

  Neurology 20010724

• Improvement of stiff-person syndrome with tiagabine.

  Neurology 20010724

• Effect of tiagabine and topiramate on porphyrin metabolism in an in vivo model of porphyria.

  Pharmacology & toxicology 20010701

• Transient dystonias in three patients treated with tiagabine.

  Epilepsia 20010701

• Tiagabine treatment and DNA damage in rat astrocytes: an in vitro study by comet assay.

  Neuroscience letters 20010622

• Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.

  Journal of medicinal chemistry 20010621

• Efficacy of background GABA uptake in rat hippocampal slices.

  Neuroreport 20010613

• Tiagabine, a specific gamma-aminobutyric acid transporter-1 inhibitor, in the treatment of psychosis.

  Journal of clinical psychopharmacology 20010601

• Comparison of twice- and three times daily tiagabine for the adjunctive treatment of partial seizures in refractory patients with epilepsy: an open label, randomised, parallel-group study.

  Epileptic disorders : international epilepsy journal with videotape 20010601

• [An open study of tiagabine in partial epilepsy].

  Revista de neurologia 20010601

• Tiagabine: efficacy and safety in adjunctive treatment of partial seizures.

  Epilepsia 20010401

• Status epilepticus and tiagabine therapy: review of safety data and epidemiologic comparisons.

  Epilepsia 20010301

• Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model.

  Journal of the Association for Research in Otolaryngology : JARO 20010301

• Localization and pharmacological characterization of voltage dependent calcium channels in cultured neocortical neurons.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20010201

• Non-convulsive status epilepticus in two patients receiving tiagabine add-on treatment.

  Journal of neurology 20010201

• [Antiepileptic drugs and neuropathic pain].

  Revista de neurologia 20010201

• The GABA uptake inhibitor tiagabine promotes slow wave sleep in normal elderly subjects.

  Neurobiology of aging 20010101

• Pharmacology and clinical experience with tiagabine.

  Expert opinion on pharmacotherapy 20010101

• Effects of antiepileptic drugs on cognition.

  Epilepsia 20010101

• Management strategies for refractory localization-related seizures.

  Epilepsia 20010101

• Tiagabine in clinical practice.

  Epilepsia 20010101

• Long-term safety of tiagabine.

  Epilepsia 20010101

• Tiagabine (gabitril) experience in children.

  Epilepsia 20010101

• Epilepsy in the elderly: the use of tiagabine.

  Epilepsia 20010101

• The short-term impact of adjunctive tiagabine on health-related quality of life.

  Epilepsia 20010101

• Antiepileptic drugs for the acute and maintenance treatment of bipolar disorder.

  Harvard review of psychiatry 20010101

• Ethical dilemmas of potential adverse events.

  Medicine and law 20010101

• Developments in mood stabilisers.

  British medical bulletin 20010101

• Clinical evaluation of Gabitril and Lamictal for drug-resistant epilepsy in adults.

  Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20010101

• Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables.

  Seizure 20000601

• 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.

  British journal of pharmacology 19970301

• Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.

  European journal of pharmacology 19941014

• Tiagabine inhibits haloperidol-induced oral dyskinesias in rats.

  Journal of neural transmission. General section 19940101