146204-42-4 | BM 212

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$42.00	$29.00
5mg	98%	in stock	$179.00	$126.00
10mg	98%	in stock	$336.00	$235.00

Description

• Catalog Number: AE81622
• Chemical Name: BM 212
• CAS Number: 146204-42-4
• Molecular Formula: C23H25Cl2N3
• Molecular Weight: 414.3707
• MDL Number: MFCD30489752
• SMILES: CN1CCN(CC1)Cc1cc(n(c1C)c1ccc(cc1)Cl)c1ccc(cc1)Cl

Computed Properties

• Complexity: 480
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 5.3

Literature

• Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity.

  Bioorganic & medicinal chemistry 20170901

• Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.

  Bioorganic & medicinal chemistry letters 20130215

• Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection.

  PloS one 20130101

• 1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation.

  European journal of medicinal chemistry 20091101

• 1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings.

  Journal of medicinal chemistry 20080626

• New derivatives of BM212: A class of antimycobacterial compounds based on the pyrrole ring as a scaffold.

  Mini reviews in medicinal chemistry 20070101

• Antimycobacterial agents. Novel diarylpyrrole derivatives of BM212 endowed with high activity toward Mycobacterium tuberculosis and low cytotoxicity.

  Journal of medicinal chemistry 20060810

• New small-molecule synthetic antimycobacterials.

  Antimicrobial agents and chemotherapy 20050601

• Antimycobacterial compounds. Optimization of the BM 212 structure, the lead compound for a new pyrrole derivative class.

  Bioorganic & medicinal chemistry 20050215

• Antimycobacterial compounds. New pyrrole derivatives of BM212.

  Bioorganic & medicinal chemistry 20040315

• Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212.

  Bioorganic & medicinal chemistry 20030220

• BM 212 and its derivatives as a new class of antimycobacterial active agents.

  Current medicinal chemistry 20021101

• New pyrrole derivatives as antimycobacterial agents analogs of BM212.

  Bioorganic & medicinal chemistry letters 19991018

• Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains.

  Antimicrobial agents and chemotherapy 19981101