146714-97-8 | WAY 100635

Packsize	Purity	Availability	Price	Discounted Price
10mg	99%	in stock	$289.00	$202.00
50mg	99%	in stock	$843.00	$590.00

Description

• Catalog Number: AE98840
• Chemical Name: WAY 100635
• CAS Number: 146714-97-8
• Molecular Formula: C25H37Cl3N4O2
• Molecular Weight: 531.9459
• MDL Number: MFCD03700823
• SMILES: COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1.Cl.Cl.Cl

Computed Properties

• Complexity: 546
• Covalently-Bonded Unit Count: 4
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 7

Literature

• 5-HTT and 5-HT(1A) receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20131001

• Serotonergic control of ingestive and post-ingestive behaviors in pigeons (Columba livia): the role of 5-HT1A receptor-mediated central mechanisms.

  Behavioural brain research 20130101

• Quantification of the radio-metabolites of the serotonin-1A receptor radioligand [carbonyl-11C]WAY-100635 in human plasma: an HPLC-assay which enables measurement of two patients in parallel.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20121201

• Preclinical and clinical characterization of the selective 5-HT(1A) receptor antagonist DU-125530 for antidepressant treatment.

  British journal of pharmacology 20121101

• Anti-dyskinetic mechanisms of amantadine and dextromethorphan in the 6-OHDA rat model of Parkinson's disease: role of NMDA vs. 5-HT1A receptors.

  The European journal of neuroscience 20121101

• Antidepressant-like effect of the novel MAO inhibitor 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice.

  Progress in neuro-psychopharmacology & biological psychiatry 20121001

• Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress.

  Journal of ethnopharmacology 20120928

• Light-dependent alteration of serotonin-1A receptor binding in cortical and subcortical limbic regions in the human brain.

  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20120901

• Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120901

• Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system.

  Psychopharmacology 20120801

• Combining image-derived and venous input functions enables quantification of serotonin-1A receptors with [carbonyl-11C]WAY-100635 independent of arterial sampling.

  NeuroImage 20120801

• Evaluation of the behavioral and pharmacokinetic profile of SYA013, a homopiperazine analog of haloperidol in rats.

  Pharmacology, biochemistry, and behavior 20120801

• Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors.

  Bioorganic & medicinal chemistry letters 20120715

• Electrophysiological impact of trazodone on the dopamine and norepinephrine systems in the rat brain.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20120701

• Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light-dark cycle.

  Journal of psychopharmacology (Oxford, England) 20120601

• 5-HT1A and 5-HT7 receptors contribute to lurasidone-induced dopamine efflux.

  Neuroreport 20120509

• In vivo electrophysiological and neurochemical effects of the selective 5-HT1A receptor agonist, F13640, at pre- and postsynaptic 5-HT1A receptors in the rat.

  Psychopharmacology 20120501

• Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.

  British journal of pharmacology 20120401

• Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT1A receptor in the caudal raphe region of the rat.

  Journal of sleep research 20120401

• Serotonin antagonists in the five-choice serial reaction time task and their interactions with nicotine.

  Behavioural pharmacology 20120401

• Ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: evidence for the involvement of the serotonergic system.

  European journal of pharmacology 20120315

• Differential respiratory control of the upper airway and diaphragm muscles induced by 5-HT1A receptor ligands.

  Sleep & breathing = Schlaf & Atmung 20120301

• Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor.

  Cellular and molecular life sciences : CMLS 20120201

• Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: descending monoamine system and opioid receptors are differentially involved.

  Neuropharmacology 20120201

• Clozapine Reverses Phencyclidine-Induced Desynchronization of Prefrontal Cortex through a 5-HT(1A) Receptor-Dependent Mechanism.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120201

• Intrahippocampal injection of brain-derived neurotrophic factor increases anxiety-related, but not panic-related defensive responses: involvement of serotonin.

  Behavioural pharmacology 20120201

• Cannabidiol injected into the bed nucleus of the stria terminalis reduces the expression of contextual fear conditioning via 5-HT1A receptors.

  Journal of psychopharmacology (Oxford, England) 20120101

• Improving voiding efficiency in the diabetic rat by a 5-HT1A serotonin receptor agonist.

  Neurourology and urodynamics 20120101

• Interactions between corticotropin-releasing factor and the serotonin 1A receptor system on acoustic startle amplitude and prepulse inhibition of the startle response in two rat strains.

  Neuropharmacology 20120101

• On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice.

  Neuropharmacology 20120101

• A role for 5-HT1A receptors in the basolateral amygdala in the development of conditioned defeat in Syrian hamsters.

  Pharmacology, biochemistry, and behavior 20120101

• Serotonin 1A receptors, depression, and memory in temporal lobe epilepsy.

  Epilepsia 20120101

• Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons.

  BMC neuroscience 20120101

• Effect of aripiprazole on anxiety associated with ethanol physical dependence and on ethanol-induced place preference.

  Journal of pharmacological sciences 20120101

• Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain.

  PloS one 20120101

• [Effect of the selective ligands 5-HT(1A) receptors administration on the impulsive and self-control behavior in rats].

  Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20120101

• Blockade of 5-HT(2) receptors in the periaqueductal grey matter (PAG) abolishes the anxiolytic-like effect of 5-HT(1A) receptor antagonism in the median raphe nucleus in mice.

  Behavioural brain research 20111201

• Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor.

  European journal of medicinal chemistry 20111201

• Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice.

  Journal of psychopharmacology (Oxford, England) 20111101

• Effects of the 5-HT(6) receptor agonist ST 1936 on depression- and anhedonia-like experimental models.

  Behavioural brain research 20111010

• Unilateral lesion of the nigrostriatal pathway decreases the response of fast-spiking interneurons in the medial prefrontal cortex to 5-HT1A receptor agonist and expression of the receptor in parvalbumin-positive neurons in the rat.

  Neurochemistry international 20111001

• Presynaptic 5-HT1A is related to 5-HTT receptor density in the human brain.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20111001

• Activation of 5-hydroxytryptamine-1A receptors suppresses cardiovascular responses evoked from the paraventricular nucleus.

  American journal of physiology. Regulatory, integrative and comparative physiology 20111001

• Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain.

  Brain research 20110926

• The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass).

  Journal of ethnopharmacology 20110901

• Potential serotonin 5-HT(1A) and dopamine D(4) receptor modulation of the discriminative stimulus effects of amphetamine in rats.

  Behavioural pharmacology 20110901

• Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1.

  European journal of medicinal chemistry 20110901

• MDMA-induced c-Fos expression in oxytocin-containing neurons is blocked by pretreatment with the 5-HT-1A receptor antagonist WAY 100635.

  Brain research bulletin 20110810

• PLA2G6 gene mutation in autosomal recessive early-onset parkinsonism in a Chinese cohort.

  Neurology 20110705

• In vivo kinetics of [F-18]MEFWAY: a comparison with [C-11]WAY100635 and [F-18]MPPF in the nonhuman primate.

  Synapse (New York, N.Y.) 20110701

• Serotonergic neurotransmission in the living human brain: a positron emission tomography study using [¹¹C]dasb and [¹¹C]WAY100635 in young healthy men.

  Synapse (New York, N.Y.) 20110701

• Effect of a 5-HT1A receptor agonist (8-OH-DPAT) on external urethral sphincter activity in a rat model of pudendal nerve injury.

  American journal of physiology. Regulatory, integrative and comparative physiology 20110701

• Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone.

  Journal of psychopharmacology (Oxford, England) 20110601

• Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor.

  Journal of medicinal chemistry 20110526

• Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze.

  Neuroscience letters 20110509

• l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity.

  Synapse (New York, N.Y.) 20110501

• Agonists at the serotonin receptor (5-HT(1A)) protect the retina from severe photo-oxidative stress.

  Investigative ophthalmology & visual science 20110404

• Mapping of CBV changes in 5-HT(1A) terminal fields by functional MRI in the mouse brain.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20110401

• Asenapine improves phencyclidine-induced object recognition deficits in the rat: evidence for engagement of a dopamine D1 receptor mechanism.

  Psychopharmacology 20110401

• Chronic stress is linked to 5-HT(1A) receptor changes and functional disintegration of the limbic networks.

  NeuroImage 20110401

• Interactions between endocannabinoid and serotonergic systems in mood disorders caused by nicotine withdrawal.

  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20110401

• Mirtazapine in combination with perospirone synergistically enhances dopamine release in the rat prefrontal cortex via 5-HT1A receptor activation.

  Psychiatry and clinical neurosciences 20110401

• The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors.

  Psychopharmacology 20110201

• Neuroadaptive responses to citalopram in rats using pharmacological magnetic resonance imaging.

  Psychopharmacology 20110201

• Role of 5-HT₁(A) receptors in induction and preservation of phrenic long-term facilitation in rats.

  Respiratory physiology & neurobiology 20110131

• Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin.

  Physiology & behavior 20110110

• Effects of serotonergic drugs on locomotor activity and vigilance states in ring doves.

  Behavioural brain research 20110101

• The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats.

  The journal of sexual medicine 20110101

• Combination of escitalopram and a 5-HT(₁A) receptor antagonist selectively decreases the extracellular levels of dopamine in the nucleus accumbens relative to striatum through 5-HT(₂C) receptor stimulation; suggestive of antipsychotic potential.

  Pharmacology, biochemistry, and behavior 20110101

• Pharmacological blockade of dopamine D2 receptors by aripiprazole is not associated with striatal sensitization.

  Naunyn-Schmiedeberg's archives of pharmacology 20110101

• Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity in rats.

  The European journal of neuroscience 20110101

• Progesterone level predicts serotonin-1a receptor binding in the male human brain.

  Neuroendocrinology 20110101

• Acute and chronic treatment with serotonin reuptake inhibitors exert opposite effects on respiration in rats: possible implications for panic disorder.

  Journal of psychopharmacology (Oxford, England) 20101201

• Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter.

  Behavioural brain research 20101201

• Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors.

  Behavioural brain research 20101201

• Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems.

  Neuropharmacology 20101201

• Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.

  Journal of medicinal chemistry 20101111

• Central serotonin 1A receptor binding in temporal lobe epilepsy: a [carbonyl-(11)C]WAY-100635 PET study.

  Epilepsy & behavior : E&B 20101101

• 5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians.

  Neuroscience letters 20101029

• Escitalopram enhances the association of serotonin-1A autoreceptors to heteroreceptors in anxiety disorders.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20101027

• Cortisol plasma levels in social anxiety disorder patients correlate with serotonin-1A receptor binding in limbic brain regions.

  The international journal of neuropsychopharmacology 20101001

• The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N'-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent.

  The Journal of pharmacology and experimental therapeutics 20100901

• Acute Ca(2+)-dependent desensitization of 5-HT(1A) receptors is mediated by activation of protein kinase A (PKA) in rat serotonergic neurons.

  Neuroscience 20100811

• 5-HT1A receptor blockade reverses GABA(A) receptor alpha3 subunit-mediated anxiolytic effects on stress-induced hyperthermia.

  Psychopharmacology 20100801

• The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter.

  Neuroscience letters 20100726

• Effect of electroconvulsive therapy on 5-HT1A receptor binding in patients with depression: a PET study with [11C]WAY 100635.

  The international journal of neuropsychopharmacology 20100701

• Robust fitting of [11C]-WAY-100635 PET data.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20100701

• Role of 5-HT(1A) receptors in fluoxetine-induced lordosis inhibition.

  Hormones and behavior 20100701

• Serotonin receptor 1A modulates actin dynamics and restricts dendritic growth in hippocampal neurons.

  The European journal of neuroscience 20100701

• Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors.

  Behavioural pharmacology 20100701

• Roles of the rostroventromedial medulla and the spinal 5-HT(1A) receptor in descending antinociception induced by motor cortex stimulation in the neuropathic rat.

  Neuroscience letters 20100607

• Hypothalamic serotonin-1A receptor binding measured by PET predicts the plasma level of dehydroepiandrosterone sulfate in healthy women.

  Neuroscience letters 20100607

• 5-HT(1A) receptor binding in euthymic bipolar patients using positron emission tomography with [carbonyl-(11)C]WAY-100635.

  Journal of affective disorders 20100601

• Involvement of presynaptic 5-HT(1A) receptors in immunomodulation in conditions of psychoemotional tension.

  Neuroscience and behavioral physiology 20100601

• Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission.

  Molecular psychiatry 20100501

• Serotonergic projection from nucleus raphe pallidus to rostral ventrolateral medulla modulates cardiovascular reflex responses during acupuncture.

  Journal of applied physiology (Bethesda, Md. : 1985) 20100501

• Characterization of a spinal, urine storage reflex, inhibitory center and its regulation by 5-HT1A receptors in female cats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100501

• Serotonin-induced region-specific responses of the arcuate and ventromedial hypothalamic nuclei.

  The International journal of neuroscience 20100501

• WAY100635 blocks the hypophagia induced by 8-OH-DPAT in the hypothalamic nuclei.

  Physiology & behavior 20100419

• Involvement of the 5-HT(1A) receptor in the anti-immobility effects of fluvoxamine in the forced swimming test and mouse strain differences in 5-HT(1A) receptor binding.

  European journal of pharmacology 20100310

• Role of 5-HT1A receptors in control of lower urinary tract function in anesthetized rats.

  American journal of physiology. Renal physiology 20100301

• Endogenous activation of spinal 5-hydroxytryptamine (5-HT) receptors contributes to the thermoregulatory activation of brown adipose tissue.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100301

• Early-life blockade of 5-HT(1A) receptors alters adult anxiety behavior and benzodiazepine sensitivity.

  Biological psychiatry 20100215

• Serotonergic mechanisms on breathing modulation in the rat locus coeruleus.

  Pflugers Archiv : European journal of physiology 20100201

• LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor.

  Psychopharmacology 20100201

• Notch1 signaling related hippocampal neurogenesis in adult poststroke depression rats: a valid index for an efficient combined citalopram and WAY100635 pharmacotherapy.

  Behavioural pharmacology 20100201

• Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20100101

• Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors.

  British journal of pharmacology 20100101

• Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat.

  PloS one 20100101

• Clozapine does not require 5-HT1A receptors to block the locomotor hyperactivity induced by MK-801 Clz and MK-801 in KO1A mice.

  Neuropharmacology 20100101

• Differential involvement of 5-HT(1A) and 5-HT(1B/1D) receptors in human interferon-alpha-induced immobility in the mouse forced swimming test.

  Arzneimittel-Forschung 20100101

• Involvement of the serotonergic system in the anxiolytic-like effect caused by m-trifluoromethyl-diphenyl diselenide in mice.

  Behavioural brain research 20091228

• Effect of estradiol benzoate microinjection into the median raphe nucleus on contextual conditioning.

  Behavioural brain research 20091201

• Influence of escitalopram treatment on 5-HT 1A receptor binding in limbic regions in patients with anxiety disorders.

  Molecular psychiatry 20091101

• Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2.

  European journal of medicinal chemistry 20091101

• Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives.

  European journal of medicinal chemistry 20091101

• Evidence that 5-hydroxytryptamine(7) receptors play a role in the mediation of afferent transmission within the nucleus tractus solitarius in anaesthetized rats.

  British journal of pharmacology 20091101

• Using cerebral white matter for estimation of nondisplaceable binding of 5-HT1A receptors in temporal lobe epilepsy.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20091101

• F15063, a potential antipsychotic with dopamine D(2)/D(3) receptor antagonist and 5-HT(1A) receptor agonist properties: influence on immediate-early gene expression in rat prefrontal cortex and striatum.

  European journal of pharmacology 20091012

• Mutant 5-hydroxytryptamine 1A receptor D116A is a receptor activated solely by synthetic ligands with a rich pharmacology.

  The Journal of pharmacology and experimental therapeutics 20091001

• Role of spinal serotonergic pathways in sneeze-induced urethral continence reflex in rats.

  American journal of physiology. Renal physiology 20091001

• The firing activity of pyramidal neurons in medial prefrontal cortex and their response to 5-hydroxytryptamine-1A receptor stimulation in a rat model of Parkinson's disease.

  Neuroscience 20090915

• Serotonin targets inhibitory synapses to induce modulation of network functions.

  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20090912

• Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice.

  The international journal of neuropsychopharmacology 20090901

• Elevated serotonin 1A binding in remitted major depressive disorder: evidence for a trait biological abnormality.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090901

• 5-HT1A receptor activation is necessary for 5-MeODMT-dependent potentiation of feeding inhibition.

  Pharmacology, biochemistry, and behavior 20090901

• Differential effects of M1 and 5-hydroxytryptamine1A receptors on atypical antipsychotic drug-induced dopamine efflux in the medial prefrontal cortex.

  The Journal of pharmacology and experimental therapeutics 20090901

• Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090901

• The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems.

  Neuropharmacology 20090901

• Serotonergic modulation of the trigeminocardiac reflex neurotransmission to cardiac vagal neurons in the nucleus ambiguus.

  Journal of neurophysiology 20090901

• Blockade of 5-HT(1A) receptors in the phrenic nucleus of the rat attenuated raphe induced activation of the phrenic nerve activity.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090901

• Memory time-course: mRNA 5-HT1A and 5-HT7 receptors.

  Behavioural brain research 20090824

• Behavioural and electroencephalographic effects of systemic injections of 8-OH-DPAT in the pigeon (Columba livia).

  Behavioural brain research 20090812

• Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects.

  Human brain mapping 20090801

• Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression.

  Biological psychiatry 20090801

• Individual differences in the sensitivity to serotonergic drugs: a pharmacobehavioural approach using rats selected on the basis of their response to novelty.

  Psychopharmacology 20090801

• Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats.

  International journal of molecular medicine 20090801

• Gene expression in the anterior cingulate cortex and amygdala of adolescent marmoset monkeys following parental separations in infancy.

  The international journal of neuropsychopharmacology 20090701

• Enhancement of cortical extracellular 5-HT by 5-HT1A and 5-HT2C receptor blockade restores the antidepressant-like effect of citalopram in non-responder mice.

  The international journal of neuropsychopharmacology 20090701

• Serotonin transporter genotype is associated with cognitive performance but not regional 5-HT1A receptor binding in humans.

  The international journal of neuropsychopharmacology 20090701

• The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism.

  Psychopharmacology 20090701

• Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine.

  British journal of pharmacology 20090701

• The contribution of serotonin 1A receptors to kappa opioid immunosuppression.

  Neuroscience and behavioral physiology 20090701

• Differential associations between brain 5-HT(1A) receptor binding and response to pain versus touch.

  Journal of neural transmission (Vienna, Austria : 1996) 20090701

• Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation.

  Journal of psychiatry & neuroscience : JPN 20090701

• Activation of 5-HT receptors in the periaqueductal gray attenuates the tachycardia evoked from dorsomedial hypothalamus.

  Autonomic neuroscience : basic & clinical 20090615

• The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in rats.

  Psychopharmacology 20090601

• Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model.

  Planta medica 20090601

• The selective 5-hydroxytryptamine 1A antagonist, AZD7371 [3(R)-(N,N-dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide (R,R)-tartrate monohydrate] (robalzotan tartrate monohydrate), inhibits visceral pain-related visceromotor, but not autonomic cardiovascular, responses to colorectal distension in rats.

  The Journal of pharmacology and experimental therapeutics 20090601

• Imipramine counteracts corticosterone-induced alterations in the effects of the activation of 5-HT(7) receptors in rat hippocampus.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090601

• Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats.

  Journal of neuroscience research 20090515

• 5-HT(1A) receptor and 5-HTT binding during the menstrual cycle in healthy women examined with [(11)C] WAY100635 and [(11)C] MADAM PET.

  Psychiatry research 20090430

• Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI.

  Psychopharmacology 20090401

• Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, part 1.

  European journal of medicinal chemistry 20090401

• Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper.

  Endocrinology 20090401

• Lateralization of the serotonin-1A receptor distribution in language areas revealed by PET.

  NeuroImage 20090401

• Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts.

  Planta medica 20090401

• Interactions between the serotonergic and histaminergic systems in the central cardiovascular regulation in haemorrhage-shocked rats: involvement of 5-HT(1A) receptors.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090401

• The counteraction of opioid-induced ventilatory depression by the serotonin 1A-agonist 8-OH-DPAT does not antagonize antinociception in rats in situ and in vivo.

  Anesthesia and analgesia 20090401

• Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20090401

• Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons.

  Biological & pharmaceutical bulletin 20090401

• The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test.

  Progress in neuro-psychopharmacology & biological psychiatry 20090317

• Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal firing of the midbrain raphe nuclei 5-HT neurons and a decrease of their response to 5-HT(1A) receptor stimulation in the rat.

  Neuroscience 20090317

• Effects of bifeprunox and aripiprazole on rat serotonin and dopamine neuronal activity and anxiolytic behaviour.

  Journal of psychopharmacology (Oxford, England) 20090301

• Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice.

  Biological psychiatry 20090301

• Characterization of serotonin receptors in pregnant human myometrium.

  The Journal of pharmacology and experimental therapeutics 20090301

• Decline in serotonergic firing activity and desensitization of 5-HT1A autoreceptors after chronic unpredictable stress.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090301

• Antagonism of 5-HT(1A) receptors uncovers an excitatory effect of SSRIs on 5-HT neuronal activity, an action probably mediated by 5-HT(7) receptors.

  Journal of neurochemistry 20090301

• An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice.

  Journal of pharmacological sciences 20090301

• Serotonin 5-HT(2) and 5-HT(1A)-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster.

  Neuroscience 20090218

• Role of serotonin 5-HT1A receptors in the antidepressant-like effect and the antinociceptive effect of venlafaxine in mice.

  The international journal of neuropsychopharmacology 20090201

• Allosteric modulation of 5-HT(1A) receptors by zinc: Binding studies.

  Neuropharmacology 20090201

• Antinociceptive activity of Tilia americana var. mexicana inflorescences and quercetin in the formalin test and in an arthritic pain model in rats.

  Neuropharmacology 20090201

• WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation.

  Behavioural pharmacology 20090201

• Inhibition of monoamine oxidases desensitizes 5-HT1A autoreceptors and allows nicotine to induce a neurochemical and behavioral sensitization.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090128

• A fully automated one-pot synthesis of [carbonyl-11C]WAY-100635 for clinical PET applications.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20090101

• Cocaine conditioning: reversal by autoreceptor dose levels of 8-OHDPAT.

  Pharmacology, biochemistry, and behavior 20090101

• 5-HT(1A) receptors in the frontal cortical brain areas in Cloninger type 1 and 2 alcoholics measured by whole-hemisphere autoradiography.

  Alcohol and alcoholism (Oxford, Oxfordshire) 20090101

• 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats.

  British journal of pharmacology 20090101

• [Involvement of presynaptic 5-HT1A receptors in immunomodulation under conditions of psychoemotional state].

  Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20090101

• Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans.

  BMC neuroscience 20090101

• Reduction of the number of new cells reaching olfactory bulbs impairs olfactory perception in the adult opossum.

  Acta neurobiologiae experimentalis 20090101

• Bidirectional modulation of classical fear conditioning in mice by 5-HT(1A) receptor ligands with contrasting intrinsic activities.

  Neuropharmacology 20090101

• The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation.

  Behavioural brain research 20081216

• Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia.

  Behavioural brain research 20081216

• The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635.

  European journal of nuclear medicine and molecular imaging 20081201

• Social instigation and aggressive behavior in mice: role of 5-HT1A and 5-HT1B receptors in the prefrontal cortex.

  Psychopharmacology 20081201

• Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice.

  Psychopharmacology 20081201

• WAY100635 prevents the changes induced by fluoxetine upon the 5-HT1A receptor functionality.

  Neuropharmacology 20081201

• Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat.

  Neuropharmacology 20081201

• Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract is mediated via the GABAergic system.

  Planta medica 20081201

• 5-HT(1A) and 5-HT(1B) receptors in the ventrolateral striatum differentially modulate apomorphine-induced jaw movements in rats.

  Journal of oral science 20081201

• Involvement of median raphe nucleus 5-HT1A receptors in the regulation of generalized anxiety-related defensive behaviours in rats.

  Neuroscience letters 20081121

• Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2.

  Journal of medicinal chemistry 20081113

• Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081101

• Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.

  Psychopharmacology 20081101

• Involvement of glutamate neurotransmission and N-methyl-d-aspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: an electrophysiological study in the rat.

  Neuroscience 20081028

• Cholesterol reduction attenuates 5-HT1A receptor-mediated signaling in human primary neuronal cultures.

  Naunyn-Schmiedeberg's archives of pharmacology 20081001

• Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms.

  European journal of pharmacology 20080911

• Evidence for serotonin synthesis-dependent regulation of in vitro neuronal firing rates in the midbrain raphe complex.

  European journal of pharmacology 20080820

• Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats.

  European journal of pharmacology 20080820

• Improvement of phencyclidine-induced social behaviour deficits in rats: involvement of 5-HT1A receptors.

  Behavioural brain research 20080805

• Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats.

  Psychopharmacology 20080801

• Diphenyl diselenide exerts anxiolytic-like effect in Wistar rats: putative roles of GABAA and 5HT receptors.

  Progress in neuro-psychopharmacology & biological psychiatry 20080801

• Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system.

  European journal of pharmacology 20080728

• Serotonin inhibits GABA synaptic transmission in presympathetic paraventricular nucleus neurons.

  Neuroscience letters 20080711

• Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition.

  Science (New York, N.Y.) 20080704

• Behavior selectively elicited by novel stimuli: modulation by the 5-HT1A agonist 8-OHDPAT and antagonist WAY-100635.

  Behavioural pharmacology 20080701

• [Impact of serotonin 1A receptors in the kappa-opioid immunosuppression].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20080701

• Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080611

• Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080601

• Further evidence for an antidepressant potential of the selective sigma1 agonist SA 4503: electrophysiological, morphological and behavioural studies.

  The international journal of neuropsychopharmacology 20080601

• Role of spinal 5-HT receptors in cutaneous hypersensitivity induced by REM sleep deprivation.

  Pharmacological research 20080601

• Effect of co-administration of the selective 5-HT1A receptor antagonist WAY 100,635 and selective 5-HT1B/1D receptor antagonist GR 127,935 on anxiolytic effect of citalopram in conditioned fear stress in the rat.

  European journal of pharmacology 20080531

• Reduced sensitivity to MDMA-induced facilitation of social behaviour in MDMA pre-exposed rats.

  Progress in neuro-psychopharmacology & biological psychiatry 20080515

• 5-HT1A receptors of the lateral septum regulate inhibitory avoidance but not escape behavior in rats.

  Pharmacology, biochemistry, and behavior 20080501

• Nicotine-activated descending facilitation on spinal NMDA-dependent reflex potentiation from pontine tegmentum in rats.

  American journal of physiology. Renal physiology 20080501

• Serotonin decreases HIV-1 replication in primary cultures of human macrophages through 5-HT(1A) receptors.

  British journal of pharmacology 20080501

• Role of serotonergic input to the ventrolateral medulla in expression of the 10-Hz sympathetic nerve rhythm.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080501

• Behavioral characterization of serotonergic activation in the flatworm Planaria.

  Behavioural pharmacology 20080501

• Evidence for topographically organized endogenous 5-HT-1A receptor-dependent feedback inhibition of the ascending serotonin system.

  The European journal of neuroscience 20080501

• 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080401

• Modeling considerations for 11C-CUMI-101, an agonist radiotracer for imaging serotonin 1A receptor in vivo with PET.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080401

• Fish on Prozac: effect of serotonin reuptake inhibitors on cognition in goldfish.

  Behavioral neuroscience 20080401

• Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study.

  Fertility and sterility 20080301

• Regulation of conditioned and unconditioned fear in rats by 5-HT1A receptors in the dorsal periaqueductal gray.

  Pharmacology, biochemistry, and behavior 20080301

• Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581.

  Pharmacology, biochemistry, and behavior 20080301

• Phrenic nerve activity is enhanced by 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anesthetized rats.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080301

• Do selective serotonin reuptake inhibitors acutely increase frontal cortex levels of serotonin?

  European journal of pharmacology 20080212

• 5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice.

  Behavioural brain research 20080211

• Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET.

  NeuroImage 20080201

• Perinatal exposure to 5-methoxytryptamine, behavioural-stress reactivity and functional response of 5-HT1A receptors in the adolescent rat.

  Behavioural brain research 20080110

• A positron emission tomography study to assess binding of lecozotan, a novel 5-hydroxytryptamine-1A silent antagonist, to brain 5-HT1A receptors in healthy young and elderly subjects, and in patients with Alzheimer's disease.

  Clinical pharmacology and therapeutics 20080101

• In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs.

  Pharmacology, biochemistry, and behavior 20080101

• Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents.

  Pharmacology, biochemistry, and behavior 20080101

• Activation of septal 5-HT1A receptors alters spatial memory encoding, interferes with consolidation, but does not affect retrieval in rats subjected to a water-maze task.

  Hippocampus 20080101

• The stimulus effects of 8-OH-DPAT: evidence for a 5-HT2A receptor-mediated component.

  Pharmacology, biochemistry, and behavior 20080101

• Activation of 5-HT(1A) receptors attenuates tachycardia induced by restraint stress in rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080101

• A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain.

  Psychopharmacology 20071201

• WAY-100635 has high selectivity for serotonin 5-HT(1A) versus dopamine D(4) receptors.

  European journal of pharmacology 20071121

• 3,4-Methylenedioxymethamphetamine- and 8-hydroxy-2-di-n-propylamino-tetralin-induced hypothermia: role and location of 5-hydroxytryptamine 1A receptors.

  The Journal of pharmacology and experimental therapeutics 20071101

• Characterization of 4-(2-hydroxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-fluorobenzamido]ethyl]piperazine (p-DMPPF) as a new potent 5-HT1A antagonist.

  British journal of pharmacology 20071101

• Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent.

  Neuropharmacology 20071101

• Diabetes-induced changes in 5-hydroxytryptamine modulation of vagally-induced bradycardia in rat heart.

  Clinical and experimental pharmacology & physiology 20071101

• Reciprocal effects of combined administration of serotonin, noradrenaline and dopamine reuptake inhibitors on serotonin and dopamine levels in the rat prefrontal cortex: the role of 5-HT1A receptors.

  Journal of psychopharmacology (Oxford, England) 20071101

• The selective 5-HT1A receptor antagonist WAY-100635 inhibits neuronal activity of the ventromedial prefrontal cortex in a rodent model of Parkinson's disease.

  Neuroscience bulletin 20071101

• Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain.

  Brain research 20071003

• Effect of early rearing conditions on alcohol drinking and 5-HT1A receptor function in C57BL/6J mice.

  The international journal of neuropsychopharmacology 20071001

• A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease.

  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20071001

• Descending facilitation of spinal NMDA-dependent reflex potentiation from pontine tegmentum in rats.

  American journal of physiology. Renal physiology 20071001

• Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice.

  Neuropharmacology 20071001

• Serotonin-1A receptor imaging in recurrent depression: replication and literature review.

  Nuclear medicine and biology 20071001

• [Presynaptic 5-HT1A receptors in immunomodulation].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20071001

• Regulation of serotonin-1A receptor function in inducible brain-derived neurotrophic factor knockout mice after administration of corticosterone.

  Biological psychiatry 20070901

• Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons.

  Psychopharmacology 20070901

• Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study.

  The American journal of psychiatry 20070901

• Hippocampal Bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-HT(1A) or 5-HT(2C/2B) receptor antagonists.

  European journal of pharmacology 20070813

• Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice.

  Pain 20070801

• Parametric and regional maps of free serotonin 5HT1A receptor sites in human brain as function of age in healthy humans.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070801

• 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.

  Drug metabolism and disposition: the biological fate of chemicals 20070801

• Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats.

  Psychopharmacology 20070701

• A PET study of effects of chronic 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on serotonin markers in Göttingen minipig brain.

  Synapse (New York, N.Y.) 20070701

• Antagonist-induced increase in 5-HT1A-receptor expression in adult rat hippocampus and cortex.

  Synapse (New York, N.Y.) 20070701

• Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635.

  Synapse (New York, N.Y.) 20070701

• Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity.

  Behavioural pharmacology 20070701

• Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus.

  Nature neuroscience 20070701

• Role of 5-HT receptor antagonists in mediating intracavernous pressure response induced by fluvoxamine in conscious rats.

  The journal of sexual medicine 20070701

• Anxiolytic-like effects of sinapic acid in mice.

  Life sciences 20070627

• Antipsychotic-like effect by combined treatment with citalopram and WAY 100635: involvement of the 5-HT2C receptor.

  The international journal of neuropsychopharmacology 20070601

• Optimal metabolite curve fitting for kinetic modeling of 11C-WAY-100635.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070601

• A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ('ecstasy').

  Neuroscience 20070511

• Reduced serotonin-1A receptor binding in social anxiety disorder.

  Biological psychiatry 20070501

• Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa.

  Biological psychiatry 20070501

• F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. II. Activity in models of positive symptoms of schizophrenia.

  British journal of pharmacology 20070501

• Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system.

  Pharmacology, biochemistry, and behavior 20070501

• Involvement of 5-HT1A and GABAA receptors in the anxiolytic-like effects of Cinnamomum cassia in mice.

  Pharmacology, biochemistry, and behavior 20070501

• 8-Hydroxy-2-(di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors.

  Methods and findings in experimental and clinical pharmacology 20070501

• 5-HT2A serotoninergic receptor in the locus coeruleus participates in the first phase of lipopolysaccharide-induced fever.

  Canadian journal of physiology and pharmacology 20070501

• Role of peripheral 5-HT1A receptors in detrusor over activity associated with partial bladder outlet obstruction in female rats.

  European journal of pharmacology 20070430

• Changes in the firing activity of serotonergic neurons in the dorsal raphe nucleus in a rat model of Parkinson's disease.

  Sheng li xue bao : [Acta physiologica Sinica] 20070425

• Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test.

  Journal of ethnopharmacology 20070404

• Serotonin receptor involvement in effects of restraint on female rat lordosis behavior.

  Pharmacology, biochemistry, and behavior 20070401

• Role of postsynaptic serotonin1A receptors in risperidone-induced increase in acetylcholine release in rat prefrontal cortex.

  European journal of pharmacology 20070322

• The effects of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) on food intake in non-deprived C57BL6 mice.

  European journal of pharmacology 20070322

• Serotonergic drugs and spinal cord transections indicate that different spinal circuits are involved in external urethral sphincter activity in rats.

  American journal of physiology. Renal physiology 20070301

• Native rat hippocampal 5-HT1A receptors show constitutive activity.

  Molecular pharmacology 20070301

• Serotonin 5-HT1A receptor stimulates c-Jun N-terminal kinase and induces apoptosis in Chinese hamster ovary fibroblasts.

  Biochimica et biophysica acta 20070301

• Effects of the reference tissue setting on the parametric image of 11C-WAY 100635.

  Nuclear medicine communications 20070301

• Pharmacological characterization of 5-Hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach.

  Biological & pharmaceutical bulletin 20070301

• 3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors.

  Bioorganic & medicinal chemistry letters 20070215

• Screening of 5-HT1A receptor antagonists using molecularly imprinted polymers.

  Journal of the American Chemical Society 20070214

• Effects of metabotropic glutamate 2/3 receptor antagonists in the stress-induced hyperthermia test in singly housed mice.

  Psychopharmacology 20070201

• 5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats.

  European journal of pharmacology 20070126

• 5-HT1A receptor activation counteracted the effect of acute immobilization of noradrenergic neurons in the rat locus coeruleus.

  Neuroscience letters 20070122

• Desensitization of 5-HT(1A) autoreceptors induced by neonatal DSP-4 treatment.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070115

• Cellular and behavioral effects of 5-HT1A receptor agonist 8-OH-DPAT in a rat model of levodopa-induced motor complications.

  Brain research 20070105

• Effects of OPC-14523, a combined sigma and 5-HT1a ligand, on pre- and post-synaptic 5-HT1a receptors.

  Journal of psychopharmacology (Oxford, England) 20070101

• Changes in central 5-HT(1A) receptor binding in mesial temporal epilepsy measured by positron emission tomography with [(11)C]WAY100635.

  Epilepsy research 20070101

• Effects of serotonin on the intrinsic membrane properties of layer II medial entorhinal cortex neurons.

  Hippocampus 20070101

• Neurochemical identification of stereotypic burst-firing neurons in the rat dorsal raphe nucleus using juxtacellular labelling methods.

  The European journal of neuroscience 20070101

• Antidepressant-like effect of leptin in streptozotocin-induced diabetic mice.

  Pharmacology, biochemistry, and behavior 20070101

• 5-HT1A receptor agonist properties of antipsychotics determined by [35S]GTPgammaS binding in rat hippocampal membranes.

  Clinical and experimental pharmacology & physiology 20070101

• Serotonin decreases aggression via 5-HT1A receptors in the fighting fish Betta splendens.

  Pharmacology, biochemistry, and behavior 20070101

• Effects of repetitive administration of tianeptine, zinc hydroaspartate and electroconvulsive shock on the reactivity of 5-HT(7) receptors in rat hippocampus.

  Pharmacological reports : PR 20070101

• Antidepressant-like effect of combined treatment with selective sigma receptor agonists and a 5-HT1A receptor agonist in the forced swimming test in rats.

  Pharmacological reports : PR 20070101

• Zimelidine decreases seizure susceptibility in stressed mice.

  Journal of neural transmission (Vienna, Austria : 1996) 20061201

• Quantification of serotonin 5-HT1A receptors in monkey brain with [11C](R)-(-)-RWAY.

  Synapse (New York, N.Y.) 20061201

• Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635.

  Psychopharmacology 20061201

• In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (R)-(+)-8-OHDPAT inhibits levodopa-induced dyskinesia but only with\ increased motor disability.

  The Journal of pharmacology and experimental therapeutics 20061201

• In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism.

  British journal of pharmacology 20061201

• A PET study of 5-HT1A receptors at different phases of the menstrual cycle in women with premenstrual dysphoria.

  Psychiatry research 20061201

• Anxiolytic effects of the aqueous extract of Uncaria rhynchophylla.

  Journal of ethnopharmacology 20061124

• Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice.

  European journal of pharmacology 20061121

• Systemic morphine produce antinociception mediated by spinal 5-HT7, but not 5-HT1A and 5-HT2 receptors in the spinal cord.

  British journal of pharmacology 20061101

• Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity.

  Nature neuroscience 20061101

• Gender-dependent regulation of G-protein-gated inwardly rectifying potassium current in dorsal raphe neurons in knock-out mice devoid of the 5-hydroxytryptamine transporter.

  Journal of neurobiology 20061101

• Role of serotonin type 1A receptors in fluvoxamine-induced inhibition of marble-burying behavior in mice.

  Behavioural pharmacology 20061101

• Long-term effects of nicotine on the forced swimming test in mice: an experimental model for the study of depression caused by smoke.

  Neurochemistry international 20061001

• A comparison of recent parametric neuroreceptor mapping approaches based on measurements with the high affinity PET radioligands [11C]FLB 457 and [11C]WAY 100635.

  NeuroImage 20061001

• WAY-100635 is a potent dopamine D4 receptor agonist.

  Psychopharmacology 20061001

• Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20061001

• Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions.

  Brain research 20060927

• Antipsychotic-like vs cataleptogenic actions in mice of novel antipsychotics having D2 antagonist and 5-HT1A agonist properties.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060901

• Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060901

• Differential role of 5-HT1A and 5-HT1B receptors on the antinociceptive and antidepressant effect of tramadol in mice.

  Psychopharmacology 20060901

• Significance of initial emotional state for neuroimmunomodulation in conditions of activation and blockade of 5-HT(1A) receptors.

  Neuroscience and behavioral physiology 20060901

• Facilitating antidepressant-like actions of estrogens are mediated by 5-HT1A and estrogen receptors in the rat forced swimming test.

  Psychoneuroendocrinology 20060901

• SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain.

  Neuropharmacology 20060901

• Attenuation by the 5-HT1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice.

  Neuropharmacology 20060901

• Characteristics of binding of [3H]WAY100635 to rat hippocampal membranes.

  Neurochemical research 20060901

• Activation of lumbosacral 5-HT2C receptors induces bursts of rhythmic activity in sympathetic nerves to the vas deferens in male rats.

  British journal of pharmacology 20060801

• Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse.

  The European journal of neuroscience 20060801

• Alteration of 5-HIAA levels in frontal cortex and dorsal raphe nucleus in rats treated with combined administration of tryptophan and ethanol.

  The Journal of toxicological sciences 20060801

• Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.

  Journal of medicinal chemistry 20060727

• Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice.

  European journal of pharmacology 20060710

• Roles of glutamatergic and serotonergic mechanisms in reflex control of the external urethral sphincter in urethane-anesthetized female rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060701

• In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties.

  Neuropharmacology 20060701

• WAY-100635 antagonist-induced plasticity of 5-HT receptors: regulatory differences between a stable cell line and an in vivo native system.

  Journal of neurochemistry 20060701

• Suppression of bladder reflex activity in chronic spinal cord injured cats by activation of serotonin 5-HT1A receptors.

  Experimental neurology 20060601

• Synthesis and in vivo biodistribution of F-18 labeled 3-cis-, 3-trans-, 4-cis-, and 4-trans-fluorocyclohexane derivatives of WAY 100635.

  Bioorganic & medicinal chemistry 20060601

• Modulation of delta opioid-evoked hypothermia in rats by WAY 100635 and fluoxetine.

  Neuroscience letters 20060508

• Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060501

• Repeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist.

  The Journal of pharmacology and experimental therapeutics 20060501

• Development of 5-HT1A receptor radioligands to determine receptor density and changes in endogenous 5-HT.

  Synapse (New York, N.Y.) 20060501

• 5-HT1A receptor activation counteracts c-Fos immunoreactivity induced in serotonin neurons of the raphe nuclei after immobilization stress in the male rat.

  Neuroscience letters 20060424

• Dissociable contribution of 5-HT1A and 5-HT2A receptors in the medial prefrontal cortex to different aspects of executive control such as impulsivity and compulsive perseveration in rats.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060401

• 5-HT receptor subtypes involved in the anxiogenic-like action and associated Fos response of acute fluoxetine treatment in rats.

  Psychopharmacology 20060401

• Augmentation by citalopram of risperidone-induced monoamine release in rat prefrontal cortex.

  Psychopharmacology 20060401

• 5-HT(1A) receptors in endogenous regulation of neuropathic hypersensitivity in the rat.

  European journal of pharmacology 20060327

• Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat.

  European journal of pharmacology 20060327

• Determination of metabolic stability of positron emission tomography tracers by LC-MS/MS: an example in WAY-100635 and two analogues.

  Journal of pharmaceutical and biomedical analysis 20060303

• Effects of 8-OH-DPAT on hippocampal NADH fluorescence in vivo in anaesthetized rats.

  Journal of neuroscience research 20060301

• Emerging drugs for premature ejaculation.

  Expert opinion on emerging drugs 20060301

• Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits.

  Brain research 20060216

• Participation of the 5-HT1A receptor in the antidepressant-like effect of estrogens in the forced swimming test.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060201

• Selective serotonin re-uptake inhibition attenuates evoked glutamate release in the dorsal horn of the anaesthetised rat in vivo.

  Pharmacological research 20060201

• The 5-HT(1A) receptor agonist 8-OH-DPAT prevents prefrontocortical glutamate and serotonin release in response to blockade of cortical NMDA receptors.

  Journal of neurochemistry 20060201

• Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in mice.

  Biological & pharmaceutical bulletin 20060201

• Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory: involvement of 5-HT1A receptors in the dorsal hippocampus in rats.

  Brain research 20060119

• Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study.

  Biological psychiatry 20060115

• Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.

  Journal of medicinal chemistry 20060112

• Light/dark cycle manipulation influences mice behaviour in the elevated plus maze.

  Behavioural brain research 20060106

• Serotonin1A autoreceptor activation by S 15535 enhances circadian activity rhythms in hamsters: evaluation of potential interactions with serotonin2A and serotonin2C receptors.

  Neuroscience 20060101

• 5-HT1a receptor antagonists block perforant path-dentate LTP induced in novel, but not familiar, environments.

  Learning & memory (Cold Spring Harbor, N.Y.) 20060101

• Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats.

  Pharmacology, biochemistry, and behavior 20060101

• Activation of serotonergic 5-HT(1A) receptors in the lateral parabrachial nucleus increases NaCl intake.

  Brain research 20051220

• Stimulation of 5-HT 1A receptors increases the seizure threshold for picrotoxin in mice.

  European journal of pharmacology 20051219

• Brain serotonin1A receptor binding in major depression is related to psychic and somatic anxiety.

  Biological psychiatry 20051215

• Effects of novel antipsychotics with mixed D(2) antagonist/5-HT(1A) agonist properties on PCP-induced social interaction deficits in the rat.

  Neuropharmacology 20051201

• 5-HT(1A) and 5-HT(2A) receptors in the rat dorsal periaqueductal gray mediate the antipanic-like effect induced by the stimulation of serotonergic neurons in the dorsal raphe nucleus.

  Psychopharmacology 20051201

• Roles of extracellular signal-regulated kinase and Akt signaling in coordinating nuclear transcription factor-kappaB-dependent cell survival after serotonin 1A receptor activation.

  Journal of neurochemistry 20051201

• Single-unit responses of serotonergic medullary raphe neurons to cardiovascular challenges in freely moving cats.

  The European journal of neuroscience 20051201

• Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.

  Proceedings of the National Academy of Sciences of the United States of America 20051129

• Repeated administration of citalopram and imipramine alters the responsiveness of rat hippocampal circuitry to the activation of 5-HT7 receptors.

  European journal of pharmacology 20051107

• Harmane inhibits serotonergic dorsal raphe neurons in the rat.

  Psychopharmacology 20051101

• Differential effects of simultaneous or sequential administration of paroxetine and WAY-100,635 on ejaculatory behavior.

  Pharmacology, biochemistry, and behavior 20051101

• The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain.

  European journal of pharmacology 20051031

• Co-administration of fluoxetine and WAY100635 improves short-term memory function.

  European journal of pharmacology 20051017

• 5-HT1A receptor-mediated G protein activation assessed by [35S]GTPgammaS binding in rat cerebral cortex.

  European journal of pharmacology 20051003

• Differential effects of the 5-hydroxytryptamine (5-HT)1A receptor inverse agonists Rec 27/0224 and Rec 27/0074 on electrophysiological responses to 5-HT1A receptor activation in rat dorsal raphe nucleus and hippocampus in vitro.

  The Journal of pharmacology and experimental therapeutics 20051001

• Contrasting contribution of 5-hydroxytryptamine 1A receptor activation to neurochemical profile of novel antipsychotics: frontocortical dopamine and hippocampal serotonin release in rat brain.

  The Journal of pharmacology and experimental therapeutics 20051001

• The 5-HT1A receptor and the stimulus effects of LSD in the rat.

  Psychopharmacology 20051001

• No interruption of lactation is needed after (11)C-WAY 100635 or (11)C-raclopride PET.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20051001

• Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor.

  The Journal of pharmacy and pharmacology 20051001

• Antidepressant-like effect of coadministration of sulpiride and fluvoxamine in mice.

  European journal of pharmacology 20050927

• 5-HT1A receptor expression during memory formation.

  Psychopharmacology 20050901

• Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test.

  Pain 20050901

• Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635.

  Archives of general psychiatry 20050901

• Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task.

  Behavioural brain research 20050830

• Differential autoinhibition of 5-hydroxytryptamine neurons by 5-hydroxytryptamine in the dorsal raphe nucleus.

  Neuroreport 20050822

• Novel antipsychotic agents with 5-HT(1A) agonist properties: role of 5-HT(1A) receptor activation in attenuation of catalepsy induction in rats.

  Neuropharmacology 20050801

• Serotonin 5-HT receptor blockade enhances Ca(2+)/calmodulin-dependent protein kinase II function and membrane expression of AMPA receptor subunits in the rat hippocampus: implications for memory formation.

  Journal of neurochemistry 20050801

• Lithium differs from anticonvulsant mood stabilizers in prefrontal cortical and accumbal dopamine release: role of 5-HT(1A) receptor agonism.

  Brain research 20050712

• In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors.

  European journal of pharmacology 20050711

• alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons.

  European journal of pharmacology 20050704

• Effect of vilazodone on 5-HT efflux and re-uptake in the guinea-pig dorsal raphe nucleus.

  European journal of pharmacology 20050704

• Effects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission: an in vivo electrophysiological study in rat brain.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050701

• Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors.

  Psychopharmacology 20050701

• Paroxetine is effective in desensitizing 5-HT1A receptor function in adult offspring exposed prenatally to cocaine.

  Psychopharmacology 20050701

• Prenatal stress influences 8-OH-DPAT modulated startle responding and [3H]-8-OH-DPAT binding in rats.

  Pharmacology, biochemistry, and behavior 20050701

• Activation of 5-hydroxytryptamine 1A receptors suppresses the cardiovascular response evoked from the dorsomedial hypothalamic nucleus.

  Hypertension (Dallas, Tex. : 1979) 20050701

• A comparison of the effects of the 5HT1A antagonists MM-77 and WAY-100635 on the mouse isolated vasa deferentia.

  Autonomic & autacoid pharmacology 20050701

• Enhanced serotonin response in the hippocampus of Galphaz protein knock-out mice.

  Neuroreport 20050621

• Gender-specific 5-HT1A receptor changes in BrdU nuclear labeling patterns in neonatal dentate gyrus.

  Brain research. Developmental brain research 20050609

• Serotonergic neurons in the median raphe nucleus regulate inhibitory avoidance but not escape behavior in the rat elevated T-maze test of anxiety.

  Psychopharmacology 20050601

• The role of 5-HT in the impairment of thermoregulation observed in rats administered MDMA ('ecstasy') when housed at high ambient temperature.

  Psychopharmacology 20050601

• 5-Hydroxytryptamine 1A receptors in the paraventricular nucleus of the hypothalamus mediate oxytocin and adrenocorticotropin hormone release and some behavioral components of the serotonin syndrome.

  The Journal of pharmacology and experimental therapeutics 20050601

• Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat.

  Progress in neuro-psychopharmacology & biological psychiatry 20050601

• Dopamine and serotonin modulate the onset of metamorphosis in the ascidian Phallusia mammillata.

  Developmental biology 20050601

• Regional reductions in serotonin 1A receptor binding in juvenile myoclonic epilepsy.

  Archives of neurology 20050601

• Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan.

  Journal of medicinal chemistry 20050519

• Differential effects of 5-HT2C receptor ligands on place conditioning and locomotor activity in rats.

  European journal of pharmacology 20050516

• Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: role of 5-HT1A receptor activation.

  Brain research 20050510

• In vivo effects of local activation and blockade of 5-HT1B receptors on globus pallidus neuronal spiking.

  Brain research 20050510

• Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat.

  Neuropharmacology 20050501

• The 5-HT1A receptor and recognition memory. Possible modulation of its behavioral effects by the nitrergic system.

  Behavioural brain research 20050430

• Serotonin-induced enhancement of vasopressin and oxytocin secretion in rat neurohypophyseal tissue culture.

  Regulatory peptides 20050415

• Differential effects of intra-midbrain raphe and systemic 8-OH-DPAT on VTA self-stimulation thresholds in rats.

  Psychopharmacology 20050401

• Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050401

• [11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS.

  Brain : a journal of neurology 20050401

• Spinal 5-HT1A receptors differentially influence nociceptive processing according to the nature of the noxious stimulus in rats: effect of WAY-100635 on the antinociceptive activities of paracetamol, venlafaxine and 5-HT.

  Pain 20050401

• Biodistribution and radiation dosimetry of 11C-WAY100,635 in humans.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050401

• Role of 5-HT1A and 5-HT1B receptors in the antinociceptive effect of tramadol.

  European journal of pharmacology 20050321

• Serotonin1A-receptor antagonism blocks psychostimulant properties of diethylpropion in marmosets (Callithrix penicillata).

  European journal of pharmacology 20050321

• Selective modulation of Ca(2+) influx pathways by 5-HT regulates synaptic long-term plasticity in the hippocampus.

  Brain research 20050310

• A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050309

• Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.

  European journal of pharmacology 20050307

• A study of the brain structures involved in the acute effects of fluoxetine on REM sleep in the rat.

  The international journal of neuropsychopharmacology 20050301

• Role of 5-HT1A and 5-HT1B receptors in the hypophagic effect of 5-HT on the structure of feeding behavior.

  Medical science monitor : international medical journal of experimental and clinical research 20050301

• Citalopram combined with WAY 100635 inhibits ejaculation and ejaculation-related Fos immunoreactivity.

  European journal of pharmacology 20050210

• Evidence that the 5-HT1A autoreceptor is an important pharmacological target for the modulation of cocaine behavioral stimulant effects.

  Brain research 20050209

• Anticataleptic properties of alpha2 adrenergic antagonists in the crossed leg position and bar tests: differential mediation by 5-HT1A receptor activation.

  Psychopharmacology 20050201

• Partial 5-HT(1A) receptor agonist activity by the 5-HT(2C) receptor antagonist SB 206,553 is revealed in rats spinalized as neonates.

  Experimental neurology 20050201

• N-oxide analogs of WAY-100635: new high affinity 5-HT(1A) receptor antagonists.

  Bioorganic & medicinal chemistry 20050201

• Activation of 5-HT1A and 5-HT7 receptors in the parafascicular nucleus suppresses the affective reaction of rats to noxious stimulation.

  Pain 20050201

• Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635.

  Biological psychiatry 20050201

• In-vivo effects of the 1,2,4-piperazine derivatives MM5 and MC1, putative 5-HT agonists, on dopamine and serotonin release in rat prefrontal cortex.

  The Journal of pharmacy and pharmacology 20050201

• Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases.

  The European journal of neuroscience 20050201

• Membrane receptors involved in modulation of responses of spinal dorsal horn interneurons evoked by feline group II muscle afferents.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050119

• Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.

  Journal of medicinal chemistry 20050113

• Effects of GABA(B), 5-HT(1A), and 5-HT(2) receptor stimulation on activation and inhibition of the rat lateral amygdala following medial geniculate nucleus stimulation in vivo.

  Brain research 20050107

• Modulation of the activity of pyramidal neurons in rat prefrontal cortex by raphe stimulation in vivo: involvement of serotonin and GABA.

  Cerebral cortex (New York, N.Y. : 1991) 20050101

• Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050101

• Autoradiographic characterisation of [35S]GTPgammaS binding stimulation mediated by 5-HT1B receptor in postmortem human brain.

  Neuropharmacology 20050101

• Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo.

  Naunyn-Schmiedeberg's archives of pharmacology 20050101

• [Activation and blocking of 5-HT1A receptors influence on the immune response in CBA mice].

  Eksperimental'naia i klinicheskaia farmakologiia 20050101

• Two C-methyl derivatives of [11C]WAY-100635--effects of an amido alpha-methyl group on metabolism and brain 5-HT1A receptor radioligand behavior in monkey.

  Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20050101

• [Significance of initial emotional state for neuroimmunomodulation under conditions of activation or blockade of 5-HT1A receptors].

  Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20050101

• A review of the neuroprotective properties of the 5-HT1A receptor agonist repinotan HCl (BAYx3702) in ischemic stroke.

  CNS drug reviews 20050101

• The 5HT1A receptor agonist, 8-OH-DPAT, protects neurons and reduces astroglial reaction after ischemic damage caused by cortical devascularization.

  Brain research 20041231

• 5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors.

  Life sciences 20041210

• Role of hippocampal CaMKII in serotonin 5-HT(1A) receptor-mediated learning deficit in rats.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20041201

• Serotonin 1A receptor binding and treatment response in late-life depression.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20041201

• Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures.

  Neuropharmacology 20041201

• Acute effect of milnacipran on the relationship between the locus coeruleus noradrenergic and dorsal raphe serotonergic neuronal transmitters.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041201

• 5-HT1A receptors are differentially involved in the anxiolytic- and antidepressant-like effects of 8-OH-DPAT and fluoxetine in the rat.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041201

• Facilitatory effects of WAY-100635, a 5-HT1A receptor antagonist, on lordosis in female rats.

  Neuroscience letters 20041123

• Endogenously released 5-hydroxytryptamine depresses the spinal monosynaptic reflex via 5-HT1D receptors.

  European journal of pharmacology 20041025

• Combined treatment of quetiapine with haloperidol in animal models of antipsychotic effect and extrapyramidal side effects: comparison with risperidone and chlorpromazine.

  Psychopharmacology 20041001

• Electrophysiological evidence for the tonic activation of 5-HT(1A) autoreceptors in the rat dorsal raphe nucleus.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20041001

• Positron emission tomographic evaluation of the putative dopamine-D3 receptor ligand, [11C]RGH-1756 in the monkey brain.

  Neurochemistry international 20041001

• Intracerebroventricular injection of trazodone produces 5-HT receptor subtype mediated anti-nociception at the supraspinal and spinal levels.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041001

• Regulators of G-protein signaling 4: modulation of 5-HT1A-mediated neurotransmitter release in vivo.

  Brain research 20041001

• Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis.

  Brain research 20040917

• Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression?

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040901

• Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury.

  The Journal of pharmacology and experimental therapeutics 20040901

• A positron emission tomography study of the 5-HT1A receptor in schizophrenia and during clozapine treatment.

  Journal of psychopharmacology (Oxford, England) 20040901

• A 5-HT7 heteroreceptor-mediated inhibition of [3H]serotonin release in raphe nuclei slices of the rat: evidence for a serotonergic-glutamatergic interaction.

  Neurochemical research 20040801

• WAY100635 and female rat lordosis behavior.

  Brain research 20040709

• Toward brain imaging of serotonin 5-HT1A autoreceptor internalization.

  NeuroImage 20040701

• Failure of repeated electroconvulsive shock treatment on 5-HT4-receptor-mediated depolarization due to protein kinase A system in young rat hippocampal CA1 neurons.

  Journal of pharmacological sciences 20040701

• Perospirone, a novel atypical antipsychotic drug, potentiates fluoxetine-induced increases in dopamine levels via multireceptor actions in the rat medial prefrontal cortex.

  Neuroscience letters 20040624

• Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain.

  European journal of pharmacology 20040616

• Role of spinal 5-HT(1A) receptors in morphine analgesia and tolerance in rats.

  European journal of pain (London, England) 20040601

• 5-HT1A receptor activation before acute stress counteracted the induced long-term behavioral effects.

  Annals of the New York Academy of Sciences 20040601

• Blockade of supraspinal 5-HT1A receptors potentiates the inhibitory effect of venlafaxine on wind-up activity in mononeuropathic rats.

  Brain research 20040522

• Effects of the 5-HT1A receptor ligands flesinoxan and WAY 100635 given systemically or microinjected into the laterodorsal tegmental nucleus on REM sleep in the rat.

  Behavioural brain research 20040505

• Occupancy of agonist drugs at the 5-HT1A receptor.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040501

• Limbic reductions of 5-HT1A receptor binding in human temporal lobe epilepsy.

  Neurology 20040427

• Brain serotonin 1A receptor binding in bulimia nervosa.

  Biological psychiatry 20040415

• Pharmacological studies of 8-OH-DPAT-induced pupillary dilation in anesthetized rats.

  European journal of pharmacology 20040412

• Effects of nociceptin on the exploratory behavior of mice in the hole-board test.

  European journal of pharmacology 20040405

• Aripiprazole (OPC-14597) fully substitutes for the 5-HT1A receptor agonist LY293284 in the drug discrimination assay in rats.

  Psychopharmacology 20040401

• Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex.

  Psychopharmacology 20040401

• Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635.

  Molecular psychiatry 20040401

• Effect of combined administration of 5-HT1A or 5-HT1B/1D receptor antagonists and antidepressants in the forced swimming test.

  European journal of pharmacology 20040308

• Decreased 5-HT1A receptor binding in amygdala of schizophrenia.

  Biological psychiatry 20040301

• 5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus.

  Neuroscience research 20040301

• Chronic fluoxetine-induced desensitization of 5-HT1A and 5-HT1B autoreceptors: regional differences and effects of WAY-100635.

  European journal of pharmacology 20040213

• Further characterization of the 5-HT1 receptors mediating cardiac sympatho-inhibition in pithed rats: pharmacological correlation with the 5-HT1B and 5-HT1D subtypes.

  Naunyn-Schmiedeberg's archives of pharmacology 20040201

• Differential autoreceptor control of extracellular 5-HT in guinea pig and rat: species and regional differences.

  Psychopharmacology 20040201

• Involvement of 5-HT1A receptors in behavioural effects of the cannabinoid receptor agonist CP 55,940 in male rats.

  Behavioural pharmacology 20040201

• 5-HT1A-mediated promotion of mitogen-activated T and B cell survival and proliferation is associated with increased translocation of NF-kappaB to the nucleus.

  Brain, behavior, and immunity 20040101

• OS-EM and FBP reconstructions at low count rates: effect on 3D PET studies of [11C] WAY-100635.

  NeuroImage 20040101

• The pyridinyl-6 position of WAY-100635 as a site for radiofluorination--effect on 5-HT1A receptor radioligand behavior in vivo.

  Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20040101

• Endogenous 5-HT inhibits firing activity of hippocampal CA1 pyramidal neurons during conditioned fear stress-induced freezing behavior through stimulating 5-HT1A receptors.

  Hippocampus 20040101

• Direct activation by dopamine of recombinant human 5-HT1A receptors: comparison with human 5-HT2C and 5-HT3 receptors.

  Synapse (New York, N.Y.) 20031215

• Anxiolytic-like effects of the selective 5-HT1A receptor antagonist WAY 100635 in non-human primates.

  European journal of pharmacology 20031215

• 5-HT7 receptors increase the excitability of rat hippocampal CA1 pyramidal neurons.

  Brain research 20031212

• SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist. I: Neurochemical and electrophysiological profile.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031201

• Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031201

• Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors.

  Cellular signalling 20031201

• The serotonergic system may be involved in the sleep-inducing action of oleamide in rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20031201

• Determination of volume of distribution using likelihood estimation in graphical analysis: elimination of estimation bias.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20031201

• 5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy.

  Experimental neurology 20031201

• LABORAS: Initial pharmacological validation of a system allowing continuous monitoring of laboratory rodent behaviour.

  Journal of neuroscience methods 20031130

• Lack of effect of a single dose of hydrocortisone on serotonin(1A) receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635.

  Biological psychiatry 20031101

• The serotonin system and spiritual experiences.

  The American journal of psychiatry 20031101

• The 5-HT1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice.

  Psychopharmacology 20031001

• 5-Hydroxytryptamine 1A receptors inhibit cold-induced sympathetically mediated cutaneous vasoconstriction in rabbits.

  The Journal of physiology 20031001

• Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors.

  British journal of pharmacology 20031001

• Sex hormone-dependent desensitization of 5-HT1A autoreceptors in knockout mice deficient in the 5-HT transporter.

  The European journal of neuroscience 20031001

• Orienting and defensive behaviors elicited by superior colliculus stimulation in rats: effects of 5-HT depletion, uptake inhibition, and direct midbrain or frontal cortex application.

  Behavioural brain research 20030915

• The 5-HT 1A receptor antagonist WAY 100635 improves rats performance in different models of amnesia evaluated by the object recognition task.

  Brain research 20030905

• Cerebrospinal fluid monoamine and metabolite concentrations and aggression in rats.

  Hormones and behavior 20030901

• Suppression of the micturition reflex in urethane-anesthetized rats by intracerebroventricular injection of WAY100635, a 5-HT(1A) receptor antagonist.

  Brain research 20030808

• Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors.

  British journal of pharmacology 20030801

• Responses to serotonin (5HT) in isolated corpus cavernosum penis of rabbit.

  International journal of impotence research 20030801

• Activation of post-synaptic 5-HT(1A) receptors in the dorsal hippocampus prevents learned helplessness development.

  Brain research 20030718

• Synthesis of a [6-pyridinyl-18F]-labelled fluoro derivative of WAY-100635 as a candidate radioligand for brain 5-HT1A receptor imaging with PET.

  Bioorganic & medicinal chemistry 20030703

• Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice.

  Journal of neurochemistry 20030701

• Do different mechanisms underlie two anxiogenic effects of systemic nicotine?

  Behavioural pharmacology 20030701

• Involvement of presynaptic 5-HT(1A) and benzodiazepine receptors in the anticonflict activity of 5-HT(1A) receptor antagonists.

  European journal of pharmacology 20030613

• The novel analgesic and high-efficacy 5-HT1A receptor agonist, F 13640 induces c-Fos protein expression in spinal cord dorsal horn neurons.

  Brain research 20030606

• A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in rats.

  Psychopharmacology 20030601

• Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists.

  Neuropharmacology 20030601

• Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate-early gene Arc in rat brain.

  Neuropharmacology 20030601

• Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration.

  Journal of neurochemistry 20030601

• Administration of the 5-hydroxytryptamine(1A) receptor antagonist WAY100635 suppresses acute experimental allergic encephalomyelitis in Lewis rats.

  Neuroscience letters 20030515

• Effects of 8-OH-DPAT and WAY-100635 on performance on a time-constrained progressive-ratio schedule.

  Psychopharmacology 20030501

• 5-HT1A agonists: alcohol drinking in rats and squirrel monkeys.

  Psychopharmacology 20030501

• A comparison of the effects of loxapine with ziprasidone and thioridazine on the release of dopamine and acetylcholine in the prefrontal cortex and nucleus accumbens.

  Psychopharmacology 20030501

• WAY-100635, an antagonist of 5-HT(1A) receptor, causes malformations of the CNS in ascidian embryos.

  Development genes and evolution 20030501

• Adaptive changes in the reactivity of 5-HT1A and 5-HT2 receptors induced in rat frontal cortex by repeated imipramine and citalopram.

  Naunyn-Schmiedeberg's archives of pharmacology 20030501

• Serotonin upregulates the activity of phagocytosis through 5-HT1A receptors.

  British journal of pharmacology 20030501

• Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain.

  Pharmacology 20030401

• Reversal of visual attention dysfunction after AMPA lesions of the nucleus basalis magnocellularis (NBM) by the cholinesterase inhibitor donepezil and by a 5-HT1A receptor antagonist WAY 100635.

  Psychopharmacology 20030401

• Positron emission tomographic analysis of dose-dependent NAD-299 binding to 5-hydroxytryptamine-1A receptors in the human brain.

  Psychopharmacology 20030401

• Ambient temperature influences core body temperature response in rat lines bred for differences in sensitivity to 8-hydroxy-dipropylaminotetralin.

  The Journal of pharmacology and experimental therapeutics 20030401

• Alpha2-adrenoreceptor activation inhibits LTP and LTD in the basolateral amygdala: involvement of Gi/o-protein-mediated modulation of Ca2+-channels and inwardly rectifying K+-channels in LTD.

  The European journal of neuroscience 20030401

• Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant.

  Pharmacology, biochemistry, and behavior 20030401

• Pharmacological characterization of MP349, a novel 5-HT1A-receptor antagonist with anxiolytic-like activity, in mice and rats.

  The Journal of pharmacy and pharmacology 20030401

• Occupancy of 5-HT1A receptors by clozapine in the primate brain: a PET study.

  Psychopharmacology 20030301

• Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorder.

  Psychopharmacology 20030301

• Tremor in Parkinson's disease and serotonergic dysfunction: an 11C-WAY 100635 PET study.

  Neurology 20030225

• Discriminative stimulus properties of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(+/-)DOI] in C57BL/6J mice.

  Psychopharmacology 20030201

• Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory.

  The American journal of psychiatry 20030201

• Selective 5-HT1A antagonists WAY 100635 and NAD-299 attenuate the impairment of passive avoidance caused by scopolamine in the rat.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030201

• Activation of 5-HT(1A) autoreceptors enhances the inhibitory effect of galanin on hippocampal 5-HT release in vivo.

  Neuropharmacology 20030201

• The 5-HT1A receptor agonist MKC-242 increases the exploratory activity of mice in the elevated plus-maze.

  European journal of pharmacology 20030101

• Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture.

  Neuroscience 20030101

• An in vitro assay for predicting successful imaging radiotracers.

  Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20030101

• Molecular dynamics simulations of the ligand-induced chemical information transfer in the 5-HT(1A) receptor.

  Journal of chemical information and computer sciences 20030101

• In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response.

  Psychopharmacology 20021201

• Antagonism by WAY-100635 of the effects of 8-OH-DPAT on performance on a free-operant timing schedule in intact and 5-HT-depleted rats.

  Behavioural pharmacology 20021201

• Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study.

  Journal of psychopharmacology (Oxford, England) 20021201

• Effect of 5-HT1A receptor-mediated serotonin augmentation on Fos immunoreactivity in rat brain.

  European journal of pharmacology 20021129

• Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635.

  Brain research 20021108

• Modulation of reflexly evoked vagal bradycardias by central 5-HT1A receptors in anaesthetized rabbits.

  British journal of pharmacology 20021101

• 5-HT1A receptor-mediated autoinhibition does not function at physiological firing rates: evidence from in vitro electrophysiological studies in the rat dorsal raphe nucleus.

  Neuropharmacology 20021101

• Effects of sigma(1) receptor ligand MS-377 on D(2) antagonists-induced behaviors.

  Pharmacology, biochemistry, and behavior 20021001

• Mechanisms of nicotine actions on dorsal raphe serotoninergic neurons.

  European journal of pharmacology 20020927

• Effects of long-term acetyl-L-carnitine administration in rats: I. increased dopamine output in mesocorticolimbic areas and protection toward acute stress exposure.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020901

• Evaluation of EMD 128 130 occupancy of the 5-HT1A and the D2 receptor: a human PET study with [11C]WAY-100635 and [11C]raclopride.

  Journal of psychopharmacology (Oxford, England) 20020901

• The selective serotonin(1A)-receptor antagonist WAY 100635 blocks behavioral stimulating effects of cocaine but not ventral striatal dopamine increase.

  Behavioural brain research 20020821

• The role of 5-HT(1A) receptors in control of lower urinary tract function in cats.

  Brain research 20020816

• Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1a-receptor antagonism blocks behavioral but potentiates serotonergic activation.

  Synapse (New York, N.Y.) 20020801

• Influence of forced swimming-induced stress on the anxiolytic-like effect of 5HT(1A) agents in mice.

  Psychopharmacology 20020701

• Aging alters in a region-specific manner serotonin transporter sites and 5-HT(1A) receptor-G protein interactions in hamster brain.

  Neuropharmacology 20020701

• 5-HT(1A) and 5-HT(2A) receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex.

  Brain research 20020607

• 5-Hydroxytryptamine1A receptor occupancy by novel full antagonist 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2H)-one-1,1-dioxide: a[11C][O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide trihydrochloride (WAY-100635) positron emission tomography study in humans.

  The Journal of pharmacology and experimental therapeutics 20020601

• Involvement of 5-HT1A receptors in homeostatic and stress-induced adaptive regulations of paradoxical sleep: studies in 5-HT1A knock-out mice.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020601

• Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635.

  Archives of general psychiatry 20020601

• Effect of chronic fluoxetine and WAY-100635 treatment on serotonergic neurotransmission in the frontal cortex.

  Journal of psychopharmacology (Oxford, England) 20020601

• Evidence that the hypotensive effect of WAY 100635, a 5-HT1A receptor antagonist, is related to vascular alpha 1-adrenoceptor blockade in the adult rat.

  Autonomic & autacoid pharmacology 20020601

• Extended action of MKC-242, a selective 5-HT(1A) receptor agonist, on light-induced Per gene expression in the suprachiasmatic nucleus in mice.

  Journal of neuroscience research 20020515

• Behavioural and biochemical studies of citalopram and WAY 100635 in rat chronic mild stress model.

  Pharmacology, biochemistry, and behavior 20020501

• Enhanced detection of receptor constitutive activity in the presence of regulators of G protein signaling: applications to the detection and analysis of inverse agonists and low-efficacy partial agonists.

  Molecular pharmacology 20020501

• Synthesis, biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high affinity for the 5-HT(1A) receptor and the alpha1-adrenergic receptor.

  Nuclear medicine and biology 20020501

• Synthesis and biological evaluation of technetium(III) mixed-ligand complexes with high affinity for the cerebral 5-HT(1A) receptor and the alpha1-adrenergic receptor.

  Nuclear medicine and biology 20020501

• Modulation by 5-hT2A receptors of aggressive behavior in isolated mice.

  Japanese journal of pharmacology 20020501

• 5-HT1A agonist/antagonist modification of cocaine stimulant effects: implications for cocaine mechanisms.

  Behavioural brain research 20020415

• Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT(1A) receptors in the rat medial frontal cortex.

  Neurochemistry international 20020401

• A database of [(11)C]WAY-100635 binding to 5-HT(1A) receptors in normal male volunteers: normative data and relationship to methodological, demographic, physiological, and behavioral variables.

  NeuroImage 20020301

• The PET radioligand [carbonyl-(11)C]desmethyl-WAY-100635 binds to 5-HT(1A) receptors and provides a higher radioactive signal than [carbonyl-(11)C]WAY-100635 in the human brain.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020301

• Anxiolytic-like effect of way-100635 microinfusions into the median (but not dorsal) raphe nucleus in mice exposed to the plus-maze: influence of prior test experience.

  Brain research 20020222

• Effects of intra-hippocampal infusion of WAY-100635 on plus-maze behavior in mice. Influence of site of injection and prior test experience.

  Brain research 20020208

• Increased REM sleep after intra-dorsal raphe nucleus injection of flesinoxan or 8-OHDPAT: prevention with WAY 100635.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020201

• Electroencephalographic activation by fluoxetine in rats: role of 5-HT(1A) receptors and enhancement of concurrent acetylcholinesterase inhibitor treatment.

  Neuropharmacology 20020201

• Renal sympathoinhibition mediated by 5-HT(1A) receptors in the RVLM during severe hemorrhage in rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20020101

• 5-HT7 receptors modulate synchronized network activity in rat hippocampus.

  Neuropharmacology 20020101

• A competitive interaction model predicts the effect of WAY-100,635 on the time course of R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia.

  The Journal of pharmacology and experimental therapeutics 20020101

• 5-HT(1B) receptor knockout mice show no adaptive changes in 5-HT(1A) receptor function as measured telemetrically on body temperature and heart rate responses.

  Brain research bulletin 20020101

• Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus: kinetic beta measurements combined with microdialysis.

  Journal of neurochemistry 20020101

• Nad-299 antagonises 5-HT-stimulated and spiperone-inhibited [35S]GTPgammaS binding in cloned 5-HT1A receptors.

  Journal of receptor and signal transduction research 20020101

• Serotonin (1A) receptor ligands act on norepinephrine neuron firing through excitatory amino acid and GABA(A) receptors: a microiontophoretic study in the rat locus coeruleus.

  Synapse (New York, N.Y.) 20011215

• Effects of aging on 5-HT(1A) receptors and their functional response to 5-HT(1a) agonist in the living brain: PET study with [carbonyl-(11)C]WAY-100635 in conscious monkeys.

  Synapse (New York, N.Y.) 20011215

• Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons.

  Brain research 20011213

• Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT(1A) receptor activation in isolated mice.

  European journal of pharmacology 20011207

• Effects of the selective norepinephrine reuptake inhibitor reboxetine on norepinephrine and serotonin transmission in the rat hippocampus.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011201

• Effects of standardized extracts of St. John's wort on the single-unit activity of serotonergic dorsal Raphe neurons in awake cats: comparisons with fluoxetine and sertraline.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011201

• Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635.

  The international journal of neuropsychopharmacology 20011201

• 5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats.

  European journal of pharmacology 20011130

• Cocaine and serotonin: a role for the 5-HT(1A) receptor site in the mediation of cocaine stimulant effects.

  Behavioural brain research 20011129

• Agonist-induced internalization of serotonin-1a receptors in the dorsal raphe nucleus (autoreceptors) but not hippocampus (heteroreceptors).

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20011101

• Effects of endogenous neurotransmitters on the in vivo binding of dopamine and 5-HT radiotracers in mice.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011101

• The role of central 5-HT(1A) receptors in the control of B-fibre cardiac and bronchoconstrictor vagal preganglionic neurones in anaesthetized cats.

  The Journal of physiology 20011101

• Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices.

  Journal of neurochemistry 20011101

• 5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20011015

• Efficacy of antipsychotic agents at human 5-HT(1A) receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation.

  European journal of pharmacology 20011005

• The role of 5-HT1B receptors in the regulation of serotonin cell firing and release in the rat brain.

  Journal of neurochemistry 20011001

• Nicotine stimulation of dorsal raphe neurons: effects on laterodorsal and pedunculopontine neurons.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20011001

• Stimulation of 5-HT(1A) receptors in the dorsal raphe ameliorates the impairment of spatial learning caused by intrahippocampal 7-chloro-kynurenic acid in naive and pretrained rats.

  Psychopharmacology 20011001

• Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype.

  The Journal of pharmacy and pharmacology 20011001

• Changes in rat cerebral blood volume due to modulation of the 5-HT(1A) receptor measured with susceptibility enhanced contrast MRI.

  Brain research 20010921

• Genetic regulation of extracellular serotonin by 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) autoreceptors in different brain regions of the mouse.

  The Journal of pharmacology and experimental therapeutics 20010901

• Regional patterns of compensation following genetic deletion of either 5-hydroxytryptamine(1A) or 5-hydroxytryptamine(1B) receptor in the mouse.

  The Journal of pharmacology and experimental therapeutics 20010901

• Inhibitory effects of tandospirone, a 5-HT1A agonist, on medial vestibular nucleus neurons responding to lateral roll tilt stimulation in rats.

  Brain research 20010810

• Effect of 5-HT on binding of [(11)C] WAY 100635 to 5-HT(IA) receptors in rat brain, assessed using in vivo microdialysis nd PET after fenfluramine.

  Synapse (New York, N.Y.) 20010801

• Inverse relationship between serotonin 5-HT(1A) receptor binding and anxiety: a [(11)C]WAY-100635 PET investigation in healthy volunteers.

  The American journal of psychiatry 20010801

• In vivo evaluation of 4-[123I]iodo-N-[2[4-(6-trifluoromethyl-2-pyridinyl)-1-piperazinyl]ethyl]benzamide, a potential SPECT radioligand for the 5-HT1A receptor.

  Nuclear medicine and biology 20010801

• DOI, a 5-HT2A/2C receptor agonist, attenuates clozapine-induced cortical dopamine release.

  Brain research 20010713

• Agonist properties of pindolol at h5-HT1A receptors coupled to mitogen-activated protein kinase.

  European journal of pharmacology 20010713

• Serotonin 5-HT1A receptor imaging in the human brain with positron-emission tomography: coordination and the standardization and dissemination of methodology.

  Journal of clinical pharmacology 20010701

• SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue.

  British journal of pharmacology 20010701

• Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man.

  Pharmacopsychiatry 20010701

• Interaction between 5-HT(1A) and 5-HT(1B) receptors: effects of 8-OH-DPAT-induced hypothermia in 5-HT(1B) receptor knockout mice.

  European journal of pharmacology 20010615

• In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia.

  European journal of pharmacology 20010608

• WAY-100635, a specific 5-HT1A antagonist, can increase the responsiveness of the mammalian circadian pacemaker to photic stimuli.

  Neuroscience letters 20010601

• Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20010601

• Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors.

  Neuroscience letters 20010525

• 5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential.

  European journal of pharmacology 20010525

• In vivo binding properties of [carbonyl-11C]WAY-100635: effect of endogenous serotonin.

  Synapse (New York, N.Y.) 20010501

• Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010501

• Effects of WAY100635, a selective 5-HT1A-receptor antagonist on the micturition-reflex pathway in the rat.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010501

• Biochemical, electrophysiological and neurohormonal studies with B-20991, a selective 5-HT1A receptor agonist.

  Pharmacology 20010501

• The differential effects of intravenously administered 8-OH-DPAT on operant food intake in satiated and food-deprived pigs are mediated by central 5-HT(1A) receptors.

  Physiology & behavior 20010501

• Differential effect of serotonin 5-HT(1A) receptor antagonists on the secretion of corticotropin and prolactin.

  Neuroendocrinology 20010501

• 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors.

  Bioorganic & medicinal chemistry letters 20010423

• Activation of 5-HT(1B/1D) receptors in the mesolimbic dopamine system increases dopamine release from the nucleus accumbens: a microdialysis study.

  European journal of pharmacology 20010420

• Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010401

• Sympathoinhibition from ventrolateral periaqueductal gray mediated by 5-HT(1A) receptors in the RVLM.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010401

• Stress-induced hyperthermia in the 5-HT(1A) receptor knockout mouse is normal.

  Biological psychiatry 20010401

• Involvement of 5-HT1A and 5-HT1B receptors for citalopram-induced hypothermia in the rat.

  Psychopharmacology 20010401

• Gender-specific aging effects on the serotonin 1A receptor.

  Brain research 20010323

• Differential occupancy of somatodendritic and postsynaptic 5HT(1A) receptors by pindolol: a dose-occupancy study with [11C]WAY 100635 and positron emission tomography in humans.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010301

• Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study.

  The Journal of pharmacology and experimental therapeutics 20010301

• Potentiation of the antinociceptive effect of clomipramine by a 5-ht(1A) antagonist in neuropathic pain in rats.

  British journal of pharmacology 20010301

• Activation of 5-HT(1A) but not 5-HT(1B) receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation.

  Journal of neurochemistry 20010301

• 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release.

  Journal of neurochemistry 20010301

• Multiple 5-HT(1) autoreceptor subtypes govern serotonin release in dorsal and median raphé nuclei.

  Neuropharmacology 20010301

• Acute and chronic effects of citalopram on postsynaptic 5-hydroxytryptamine(1A) receptor-mediated feedback: a microdialysis study in the amygdala.

  Journal of neurochemistry 20010301

• Short and efficient syntheses of analogues of WAY-100635: new and potent 5-HT1A receptor antagonists.

  Bioorganic & medicinal chemistry 20010301

• Development of novel mixed-ligand oxotechnetium [SNS/S] complexes as potential 5-HT1A receptor imaging agents.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20010301

• Corticosterone selectively attenuates 8-OH-DPAT-mediated hypothermia in mice.

  The international journal of neuropsychopharmacology 20010301

• Selective inhibition of amine oxidases differently potentiate the hypophagic effect of benzylamine in mice.

  European journal of pharmacology 20010209

• Endogenous 5-HT tonically inhibits spontaneous firing activity of dorsal hippocampus CA1 pyramidal neurons through stimulation of 5-HT(1A) receptors in quiet awake rats: in vivo electrophysiological evidence.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010201

• Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram.

  Naunyn-Schmiedeberg's archives of pharmacology 20010201

• Serotonergic modulation of retinal input to the mouse suprachiasmatic nucleus mediated by 5-HT1B and 5-HT7 receptors.

  Journal of biological rhythms 20010201

• New halogenated [11C]WAY analogues, [11C]6FPWAY and [11C]6BPWAY--radiosynthesis and assessment as radioligands for the study of brain 5-HT1A receptors in living monkey.

  Nuclear medicine and biology 20010201

• Exhaustion of the coital reflex in spinal male rats is reversed by the serotonergic agonist 8-OH-DPAT.

  Behavioural brain research 20010129

• Catalepsy induced by the 5-HT(1A) receptor antagonist WAY 100635 in rats pretreated with the selective serotonin reuptake inhibitor citalopram.

  European journal of pharmacology 20010112

• Desensitization of 5-HT(1A) autoreceptors by a low chronic fluoxetine dose effect of the concurrent administration of WAY-100635.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101

• Role of dorsal raphe neurons in paradoxical sleep generation in the cat: no evidence for a serotonergic mechanism.

  The European journal of neuroscience 20010101

• Differential modulation by GTPgammaS of agonist and inverse agonist binding to h5-HT(1A) receptors revealed by [3H]-WAY100,635.

  British journal of pharmacology 20010101

• Regulation of 5-HT(1A) receptor-stimulated [35S]-GtpgammaS binding as measured by quantitative autoradiography following chronic agonist administration.

  British journal of pharmacology 20010101

• Selectively bred male rat lines differ in naïve and experienced sexual behavior.

  Physiology & behavior 20010101

• Involvement of somatodendritic 5-HT(1A) receptors in Delta(9)-tetrahydrocannabinol-induced hypothermia in the rat.

  Pharmacology, biochemistry, and behavior 20010101

• The hypotensive effect of BMY 7378 is antagonized by a silent 5-HT(1A) receptor antagonist: comparison with 8-hydroxy-dipropylamino tetralin.

  Archives of medical research 20010101

• Interactive effects of cholecystokinin-8S and various serotonin receptor agonists on the firing activity of neostriatal neuronesin rats.

  Neuropeptides 20010101

• 5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20001201

• Effects of the serotonin 5-HT(2) antagonist, ritanserin, and the serotonin 5-HT(1A) antagonist, WAY 100635, on cocaine-seeking in rats.

  Pharmacology, biochemistry, and behavior 20001001

• S 15535, a benzodioxopiperazine acting as presynaptic agonist and postsynaptic 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine.

  British journal of pharmacology 19991101

• RU-24969 disrupts d-amphetamine self-administration and responding for conditioned reward via stimulation of 5-HT1B receptors.

  Behavioural pharmacology 19990301

• The effects of 5-HT1A receptor agonists, 5-HT1A receptor antagonists and their interaction on the fear-potentiated startle response.

  Psychopharmacology 19981001

• Anxiolytic effects of flesinoxan in the stress-induced hyperthermia paradigm in singly-housed mice are 5-HT1A receptor mediated.

  European journal of pharmacology 19980126

• The pharmacological characterization of a novel selective 5-hydroxytryptamine1A receptor antagonist, NAD-299.

  The Journal of pharmacology and experimental therapeutics 19971001

• Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy.

  Naunyn-Schmiedeberg's archives of pharmacology 19970601

• The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.

  European journal of pharmacology 19970501

• Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors.

  European journal of pharmacology 19970305

• Pharmacological characterization of recombinant human 5-hydroxytryptamine1A receptors using a novel antagonist radioligand, [3H]WAY-100635.

  Life sciences 19970101

• 5-HT1A receptors are not involved in clozapine's lack of cataleptogenic potential.

  Neuropharmacology 19960101