146954-75-8 | Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$29.00	$20.00
5g	95%	in stock	$116.00	$81.00
25g	95%	in stock	$535.00	$374.00

Description

• Catalog Number: AA65226
• Chemical Name: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• CAS Number: 146954-75-8
• Molecular Formula: C39H46FN4O8P
• Molecular Weight: 748.7767
• MDL Number: MFCD11113919
• SMILES: N#CCCOP(N(C(C)C)C(C)C)O[C@@H]1[C@@H](COC(c2ccc(cc2)OC)(c2ccc(cc2)OC)c2ccccc2)O[C@H]([C@@H]1F)n1ccc(=O)[nH]c1=O

Upstream Synthesis Route

The 2'-F-dU Phosphoramidite is a highly versatile and valuable tool in chemical synthesis, particularly in the field of oligonucleotide synthesis. This phosphoramidite derivative contains a 2'-fluoro (2'-F) modification on the deoxyuridine base, which imparts unique properties to the resulting oligonucleotide chains.The incorporation of 2'-F-dU Phosphoramidite into oligonucleotides offers several advantages in chemical synthesis. Due to the presence of the 2'-fluoro group, the modified nucleotide confers enhanced stability and nuclease resistance to the oligonucleotide sequence. This increased stability is particularly beneficial in applications such as antisense technologies, where the oligonucleotide must resist degradation by cellular nucleases.Moreover, the 2'-F modification in 2'-F-dU Phosphoramidite can also influence the hybridization properties of the oligonucleotide, leading to improved specificity and binding affinity with complementary nucleic acid targets. This makes the modified oligonucleotides ideal for applications in gene silencing, PCR assays, and other molecular biology techniques that require precise and efficient hybridization.Additionally, the 2'-F-dU Phosphoramidite is compatible with standard phosphoramidite chemistry commonly used in oligonucleotide synthesis, enabling easy and efficient incorporation into oligonucleotide chains. This compatibility allows researchers to seamlessly integrate the benefits of the 2'-F modification into their synthetic oligonucleotide sequences, expanding the range of applications and possibilities in nucleic acid research and biotechnology.