146998-34-7 | S15535

Packsize	Purity	Availability	Price	Discounted Price
5mg	99%	1 week	$190.00	$133.00
10mg	99%	1 week	$276.00	$193.00
25mg	99%	1 week	$500.00	$350.00
50mg	99%	1 week	$770.00	$539.00
100mg	99%	1 week	$1,202.00	$841.00

Description

• Catalog Number: AE93590
• Chemical Name: S15535
• CAS Number: 146998-34-7
• Molecular Formula: C21H24N2O2
• Molecular Weight: 336.4275
• MDL Number: MFCD00911672
• SMILES: C1COc2c(O1)cccc2N1CCN(CC1)C1Cc2c(C1)cccc2

Computed Properties

• Complexity: 437
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• XLogP3: 3.6

Literature

• Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110601

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• Bidirectional modulation of classical fear conditioning in mice by 5-HT(1A) receptor ligands with contrasting intrinsic activities.

  Neuropharmacology 20090101

• Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats.

  Psychopharmacology 20081001

• Serotonin1A autoreceptor activation by S 15535 enhances circadian activity rhythms in hamsters: evaluation of potential interactions with serotonin2A and serotonin2C receptors.

  Neuroscience 20060101

• Differences in the effects of 5-HT(1A) receptor agonists on forced swimming behavior and brain 5-HT metabolism between low and high aggressive mice.

  Psychopharmacology 20050301

• The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis.

  The Journal of pharmacology and experimental therapeutics 20041001

• The control of feather pecking by serotonin.

  Behavioral neuroscience 20040601

• Cerebrospinal fluid monoamine and metabolite concentrations and aggression in rats.

  Hormones and behavior 20030901

• Serotonergic serotonin (1A) mixed agonists/antagonists elicit large-magnitude phase shifts in hamster circadian wheel-running rhythms.

  Neuroscience 20030101

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols.

  Journal of medicinal chemistry 20020103

• Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression.

  Physiology & behavior 20010901

• Population pharmacokinetic-pharmacodynamic modelling of S 15535, a 5-HT(1A) receptor agonist, using a behavioural model in rats.

  European journal of pharmacology 20010302

• Differential modulation by GTPgammaS of agonist and inverse agonist binding to h5-HT(1A) receptors revealed by [3H]-WAY100,635.

  British journal of pharmacology 20010101

• S 15535, a benzodioxopiperazine acting as presynaptic agonist and postsynaptic 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine.

  British journal of pharmacology 19991101

• Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists.

  Naunyn-Schmiedeberg's archives of pharmacology 19980301

• The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.

  European journal of pharmacology 19970501