1478-61-1 | 2,2-Bis(4-hydroxyphenyl)hexafluoropropane

Packsize	Purity	Availability	Price	Discounted Price
5g	95%	in stock	$8.00	$5.00
25g	95%	in stock	$15.00	$10.00
500g	95%	in stock	$195.00	$136.00

Description

• Catalog Number: AB66178
• Chemical Name: 2,2-Bis(4-hydroxyphenyl)hexafluoropropane
• CAS Number: 1478-61-1
• Molecular Formula: C15H10F6O2
• Molecular Weight: 336.22911919999996
• MDL Number: MFCD00000439
• SMILES: FC(C(C(F)(F)F)(c1ccc(cc1)O)c1ccc(cc1)O)(F)F
• NSC Number: 152522

Computed Properties

• Complexity: 352
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 4.5

Literature

• Effects of bisphenol analogs on thyroid endocrine system and possible interaction with 17β-estradiol using GH3 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20181201

• Mechanism of bisphenol AF-induced progesterone inhibition in human chorionic gonadotrophin-stimulated mouse Leydig tumor cell line (mLTC-1) cells.

  Environmental toxicology 20180601

• Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists.

  Reproductive toxicology (Elmsford, N.Y.) 20180401

• Estrogenicity of halogenated bisphenol A: in vitro and in silico investigations.

  Archives of toxicology 20180301

• Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay.

  Toxicology in vitro : an international journal published in association with BIBRA 20180201

• Binding interactions of halogenated bisphenol A with mouse PPARα: In vitro investigation and molecular dynamics simulation.

  Toxicology letters 20180201

• Differential in Vitro Biological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand-ERα Complexes.

  Environmental health perspectives 20180101

• Bisphenol AF as an activator of human estrogen receptor β1 (ERβ1) in breast cancer cell lines.

  The Journal of toxicological sciences 20180101

• Bisphenol AF negatively affects oocyte maturation of mouse in vitro through increasing oxidative stress and DNA damage.

  Chemico-biological interactions 20171225

• The in vitro comparative study of the effect of BPA, BPS, BPF and BPAF on human erythrocyte membrane; perturbations in membrane fluidity, alterations in conformational state and damage to proteins, changes in ATP level and Na(+)/K(+) ATPase and AChE activities.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171201

• Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol A and Its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae.

  Environmental science & technology 20171107

• Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway.

  Environmental science & technology 20171003

• Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites.

  Toxicology in vitro : an international journal published in association with BIBRA 20171001

• Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20170801

• Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study).

  Toxicology in vitro : an international journal published in association with BIBRA 20170601

• Differential Activation of a Mouse Estrogen Receptor β Isoform (mERβ2) with Endocrine-Disrupting Chemicals (EDCs).

  Environmental health perspectives 20170401

• Thyroid hormone disrupting potentials of bisphenol A and its analogues - in vitro comparison study employing rat pituitary (GH3) and thyroid follicular (FRTL-5) cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20170401

• In vitro and in silico assessment of the structure-dependent binding of bisphenol analogues to glucocorticoid receptor.

  Analytical and bioanalytical chemistry 20170301

• Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells.

  Biological & pharmaceutical bulletin 20170101

• Predicting anti-androgenic activity of bisphenols using molecular docking and quantitative structure-activity relationships.

  Chemosphere 20161101

• Gestational and lactational exposure to bisphenol AF in maternal rats increases testosterone levels in 23-day-old male offspring.

  Chemosphere 20161101

• Exposure to Bisphenol AF disrupts sex hormone levels and vitellogenin expression in zebrafish.

  Environmental toxicology 20160301

• Effects of bisphenol analogues on steroidogenic gene expression and hormone synthesis in H295R cells.

  Chemosphere 20160301

• Estrogenic Effects of Several BPA Analogs in the Developing Zebrafish Brain.

  Frontiers in neuroscience 20160101

• Bisphenol AF stimulates transcription and secretion of C-X-C chemokine ligand 12 to promote proliferation of cultured T47D breast cancer cells.

  Toxicology 20151202

• In vivo and in silico analyses of estrogenic potential of bisphenol analogs in medaka (Oryzias latipes) and common carp (Cyprinus carpio).

  Ecotoxicology and environmental safety 20151001

• Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S.

  Toxicology in vitro : an international journal published in association with BIBRA 20150801

• Long-term effects of bisphenol AF (BPAF) on hormonal balance and genes of hypothalamus-pituitary-gonad axis and liver of zebrafish (Danio rerio), and the impact on offspring.

  Chemosphere 20150601

• Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.

  Scientific reports 20140101

• Bioactivation of bisphenol A and its analogs (BPF, BPAF, BPZ and DMBPA) in human liver microsomes.

  Toxicology in vitro : an international journal published in association with BIBRA 20130601

• Bisphenol A affects androgen receptor function via multiple mechanisms.

  Chemico-biological interactions 20130525

• Biotransformation of bisphenol AF to its major glucuronide metabolite reduces estrogenic activity.

  PloS one 20130101

• Bisphenol AF may cause testosterone reduction by directly affecting testis function in adult male rats.

  Toxicology letters 20120601

• 5,7,13,15-Tetra-oxo-2,2,10,10-tetra-kis-(trifluoro-meth-yl)-4,8,12,16-tetra-oxa-1(1,4),3(1,4),6(1,2),9(1,4),11(1,4),14(1,2)-hexa-benzenahexa-deca-phane tetra-hydro-furan monosolvate.

  Acta crystallographica. Section E, Structure reports online 20120401

• Endocrine-mediated effects of 4,4'-(hexafluoroisopropylidene)diphenol in SD rats, based on a subacute oral toxicity study.

  Archives of toxicology 20120101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Bisphenol AF is a full agonist for the estrogen receptor ERalpha but a highly specific antagonist for ERbeta.

  Environmental health perspectives 20100901

• Development of a molecularly imprinted polymer for selective extraction of bisphenol A in water samples.

  Journal of separation science 20100601

• 1,1,1,3,3,3-Hexafluoro-2,2-bis-[4-(4-nitro-phen-oxy)phen-yl]propane.

  Acta crystallographica. Section E, Structure reports online 20080801

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• Comparison of the reporter gene assay for ER-alpha antagonists with the immature rat uterotrophic assay of 10 chemicals.

  Toxicology letters 20030430

• Measurement of estrogenic activity of chemicals for the development of new dental polymers.

  Toxicology in vitro : an international journal published in association with BIBRA 20010101