147859-80-1 | Ca-074 me

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$156.00	$109.00
5mg	95%	in stock	$210.00	$147.00
10mg	95%	in stock	$366.00	$256.00
25mg	95%	in stock	$733.00	$513.00

Description

• Catalog Number: AF00162
• Chemical Name: Ca-074 me
• CAS Number: 147859-80-1
• Molecular Formula: C19H31N3O6
• Molecular Weight: 397.4659
• MDL Number: MFCD00797532
• SMILES: CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)OC)C(CC)C

Computed Properties

• Complexity: 611
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 5
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 10
• XLogP3: 1.2

Literature

• Interplay between lysosomal, mitochondrial and death receptor pathways during manganese-induced apoptosis in glial cells.

  Archives of toxicology 20170901

• Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation.

  Oncotarget 20161108

• GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death.

  Cancer letters 20130201

• Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120815

• Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process.

  Cell death and differentiation 20120801

• Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20120101

• Pepstatin A alters host cell autophagic machinery and leads to a decrease in influenza A virus production.

  Journal of cellular physiology 20111201

• An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001

• Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.

  The Journal of biological chemistry 20110930

• Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B.

  American journal of physiology. Cell physiology 20110501

• Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion.

  Breast cancer research : BCR 20110101

• Doxorubicin-induced cell death requires cathepsin B in HeLa cells.

  Biochemical pharmacology 20101115

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• A role for the lysosomal protease cathepsin B in zebrafish follicular apoptosis.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20100601

• Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.

  PLoS neglected tropical diseases 20100601

• Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.

  International journal of cancer 20100515

• Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells.

  Biological chemistry 20100501

• Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition.

  Cellular microbiology 20100201

• Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke.

  Brain research 20100122

• Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts.

  Photochemistry and photobiology 20100101

• Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.

  Virology 20091125

• Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice.

  Chinese medical journal 20091020

• Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells.

  Immunology letters 20090427

• Role of cathepsin B-mediated apoptosis in fulminant hepatic failure in mice.

  World journal of gastroenterology 20090314

• Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75.

  Molecular cancer 20090101

• IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts.

  Journal of cellular physiology 20081101

• Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat.

  Neuroscience letters 20080919

• Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.

  Nature immunology 20080801

• Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages.

  Journal of immunology (Baltimore, Md. : 1950) 20080701

• Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.

  The Journal of biological chemistry 20080321

• Fluid shear-induced activation and cleavage of CD18 during pseudopod retraction by human neutrophils.

  Journal of cellular physiology 20080201

• Calcium signaling leads to mitochondrial depolarization in impact-induced chondrocyte death in equine articular cartilage explants.

  Arthritis and rheumatism 20070701

• Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitis.

  American journal of physiology. Gastrointestinal and liver physiology 20070601

• Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells.

  Blood 20070401

• Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease.

  Biological chemistry 20070201

• Endogenous expression and endocytosis of tartrate-resistant acid phosphatase (TRACP) by osteoblast-like cells.

  Bone 20050601

• Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown.

  Cell death and differentiation 20041201

• Inhibitors of cysteine cathepsin and calpain do not prevent ultraviolet-B-induced apoptosis in human keratinocytes and HeLa cells.

  Archives of dermatological research 20040701

• Cysteine proteases and cell differentiation: excystment of the ciliated protist Sterkiella histriomuscorum.

  Eukaryotic cell 20031201

• Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin.

  Cell death and differentiation 20030901

• Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis.

  The Journal of biological chemistry 20030606

• Cathepsin B in osteoblasts.

  Biochimica et biophysica acta 20030502

• Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity.

  American journal of physiology. Gastrointestinal and liver physiology 20020901

• Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells.

  The Journal of biological chemistry 20020705

• Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas.

  International journal of cancer 20020220

• CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells.

  Biological chemistry 20020101

• Treatment with cathepsin L inhibitor potentiates Th2-type immune response in Leishmania major-infected BALB/c mice.

  International immunology 20010801

• Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions.

  The Journal of biological chemistry 20010427