148-18-5 | N,N-diethyl(sodiosulfanyl)carbothioamide

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$33.00	$23.00
5g	95%	in stock	$73.00	$51.00
25g	95%	in stock	$233.00	$163.00
100g	95%	in stock	$606.00	$424.00
500g	95%	in stock	$2,002.00	$1,402.00

Description

• Catalog Number: AA66363
• Chemical Name: N,N-diethyl(sodiosulfanyl)carbothioamide
• CAS Number: 148-18-5
• Molecular Formula: C5H10NNaS2
• Molecular Weight: 171.25937000000002
• MDL Number: MFCD00150617
• SMILES: CCN(C(=S)[S-])CC.[Na+]

Computed Properties

• Complexity: 83
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2

Literature

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• Evaluation of lipid-based carrier systems and inclusion complexes of diethyldithiocarbamate-iron to trap nitric oxide in biological systems.

  Magnetic resonance in medicine 20060101

• Mechanism of hepatic heme oxygenase-1 induction by isoflurane.

  Anesthesiology 20060101

• Real-time PCR: housekeeping genes in the INS-1E beta-cell line.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060101

• Cytochrome P450 and Parkinson's disease: protective role of neuronal CYP 2E1 from MPTP toxicity.

  Journal of neural transmission. Supplementum 20060101

• ESR techniques for the detection of nitric oxide in vivo as an index of endothelial function.

  Pharmacological reports : PR 20060101

• Diethyldithiocarbamate inhibits in vivo Cu,Zn-superoxide dismutase and perturbs free radical processes in the yeast Saccharomyces cerevisiae cells.

  Biochemical and biophysical research communications 20051230

• Release and hemodynamic influence of nitro-glycerine-derived nitric oxide in endotoxemic rats.

  Vascular pharmacology 20051201

• Dual effects of copper-zinc superoxide dismutase.

  Biochemical and biophysical research communications 20051104

• Role of CYP2E1 in deramciclane metabolism.

  Drug metabolism and disposition: the biological fate of chemicals 20051101

• Luminescence properties of metal(II)-diethyldithiocarbamate chelate complex particles and its analytical application.

  Journal of fluorescence 20051101

• Comparison of implantation and cytotoxicity testing for initially toxic biomaterials.

  Journal of biomedical materials research. Part A 20051001

• The effects of superoxide anion generators on responses to exogenous nitric oxide and non-adrenergic, non-cholinergic nerve stimulation in rat isolated penile bulb.

  Basic & clinical pharmacology & toxicology 20050901

• The development and use of an innovative laboratory method for measuring arsenic in drinking water from western Bangladesh.

  Environmental health perspectives 20050901

• Biochemical and biophysical changes induced by fungicide sodium diethyl dithiocarbamate (SDD), in phytocystatin purified from Phaseolus mungo (Urd): a commonly used Indian legume.

  Journal of agricultural and food chemistry 20050727

• Extraction of haptens from solid products and their delivery to the skin, exemplified by dithiocarbamates from rubber gloves.

  Contact dermatitis 20050701

• Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis.

  Acta pharmacologica Sinica 20050601

• Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in rats.

  Journal of gastroenterology and hepatology 20050601

• Purification and characterization of polyphenol oxidase from nettle (Urtica dioica L.) and inhibitory effects of some chemicals on enzyme activity.

  Journal of enzyme inhibition and medicinal chemistry 20050601

• Oxidative stress mediates drug-induced hepatotoxicity in rats: a possible role of DNA fragmentation.

  Toxicology 20050330

• Diethyldithiocarbamate inhibits iNOS expression in human lens epithelial cells stimulated by IFN-gamma and LPS.

  Acta pharmacologica Sinica 20050301

• Influences of DTC and zinc supplementation on the cellular response restoration in restrained mice.

  Journal of veterinary science 20050301

• c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells.

  Arteriosclerosis, thrombosis, and vascular biology 20050201

• 9,10-Phenanthraquinone in diesel exhaust particles downregulates Cu,Zn-SOD and HO-1 in human pulmonary epithelial cells: intracellular iron scavenger 1,10-phenanthroline affords protection against apoptosis.

  Free radical biology & medicine 20050201

• Purification and characterization of phenoloxidase from clam Ruditapes philippinarum.

  Fish & shellfish immunology 20050101

• Effect of copper and diethyldithiocarbamate combination therapy on the macular mouse, an animal model of Menkes disease.

  Journal of inherited metabolic disease 20050101

• Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase.

  Circulation research 20041029

• Hippocampal CA3-region is crucial for acquisition and memory consolidation in Morris water maze task in mice.

  Behavioural brain research 20041005

• Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.

  Journal of neurochemistry 20041001

• An ocular drug delivery system containing zinc diethyldithiocarbamate and HPbetaCD inclusion complex--corneal permeability, anti-cataract effects and mechanism studies.

  The Journal of pharmacy and pharmacology 20041001

• High-resolution mapping of neuronal activity by thallium autometallography.

  NeuroImage 20041001

• Diethyldithiocarbamate can induce two different type of death: apoptosis and necrosis mediating the differential MAP kinase activation and redox regulation in HL60 cells.

  Molecular and cellular biochemistry 20041001

• N,N-diethyldithiocarbamate produces copper accumulation, lipid peroxidation, and myelin injury in rat peripheral nerve.

  Toxicological sciences : an official journal of the Society of Toxicology 20040901

• Vasomotor responses in MnSOD-deficient mice.

  American journal of physiology. Heart and circulatory physiology 20040901

• Effect of cytochrome P450 inhibitors (diethyl dithiocarbamate, ketoconazole and grapefruit juice) on the pharmacokinetics of all-trans-retinoic acid.

  Farmaco (Societa chimica italiana : 1989) 20040901

• Effects of local administrations of tempol and diethyldithio-carbamic on peripheral nerve activity.

  Hypertension (Dallas, Tex. : 1979) 20040801

• Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate.

  European journal of pharmacology 20040708

• Influence of selected inhibitors on the metabolism of the styrene metabolite 4-vinylphenol in wild-type and CYP2E1 knockout mice.

  Journal of toxicology and environmental health. Part A 20040625

• Radiation protection by diethyldithiocarbamate: protection of membrane and DNA in vitro and in vivo against gamma-radiation.

  Journal of radiation research 20040601

• Vibrio cholerae periplasmic superoxide dismutase: isolation of the gene and overexpression of the protein.

  Journal of biotechnology 20040408

• Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts.

  Journal of cellular biochemistry 20040401

• Cyp1a2 protects against reactive oxygen production in mouse liver microsomes.

  Free radical biology & medicine 20040301

• Influence of polyethylene-glycol-superoxide dismutase and combined depletion and repletion of antioxidants on nitrergic relaxation in the pig gastric fundus.

  European journal of pharmacology 20040220

• Chelation of synaptic zinc induces overexcitation in the hilar mossy cells of the rat hippocampus.

  Neuroscience letters 20040123

• The induction of amyloid precursor protein and alpha-synuclein in rat hippocampal astrocytes by diethyldithiocarbamate and copper with or without glutathione.

  Toxicology letters 20040115

• Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes.

  Redox report : communications in free radical research 20040101

• Benzene metabolism in human lung cell lines BEAS-2B and A549 and cells overexpressing CYP2F1.

  Journal of biochemical and molecular toxicology 20040101

• Disulfiram metabolites permanently inactivate the human multidrug resistance P-glycoprotein.

  Molecular pharmaceutics 20040101

• Sulfallate.

  Report on carcinogens : carcinogen profiles 20040101

• Nitric oxide inhibits superoxide-stimulated urea permeability in the rat inner medullary collecting duct.

  American journal of physiology. Renal physiology 20031201

• Decreased survival of prostate cancer cells in vitro by combined treatment of heat and an antioxidant inhibitor diethyldithiocarbamate (DDC).

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20031101

• Diethyldithiocarbamate inhibits the catalytic activity of xanthine oxidase.

  FEBS letters 20030911

• Inhibition of nitrification in soil by metal diethyldithiocarbamates.

  Journal of environmental sciences (China) 20030901

• EPR investigation of in vivo inhibitory effect of guanidine compounds on nitric oxide production in rat tissues.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20030901

• Detection and description of various stores of nitric oxide store in vascular wall.

  Bulletin of experimental biology and medicine 20030901

• Effects of monoamine oxidase inhibitors on the diethyldithiocarbamate-induced enhancement of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in C57BL/6 mice.

  Journal of neural transmission (Vienna, Austria : 1996) 20030801

• Recovery of motor function and dopaminergic parameters in a mouse model of Parkinson's disease induced by co-administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and diethyldithiocarbamate.

  Journal of neural transmission (Vienna, Austria : 1996) 20030801

• Involvement of the hippocampal CA3-region in acquisition and in memory consolidation of spatial but not in object information in mice.

  Neurobiology of learning and memory 20030701

• Increased renal medullary H2O2 leads to hypertension.

  Hypertension (Dallas, Tex. : 1979) 20030701

• Diethyldithiocarbamate-induced cytotoxicity and apoptosis in leukemia cell lines.

  Biological & pharmaceutical bulletin 20030701

• Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A).

  Journal of neurochemistry 20030701

• Detection and evaluation of NO stores in awake rats.

  Bulletin of experimental biology and medicine 20030701

• Strong hg(II) complexation in municipal wastewater effluent and surface waters.

  Environmental science & technology 20030615

• The chemical reactivity of BNP7787 and its metabolite mesna with the cytostatic agent cisplatin: comparison with the nucleophiles thiosulfate, DDTC, glutathione and its disulfide GSSG.

  Cancer chemotherapy and pharmacology 20030601

• Parenteral N,N-diethyldithiocarbamate produces segmental demyelination in the rat that is not dependent on cysteine carbamylation.

  Toxicology and applied pharmacology 20030601

• Dextromethorphan prevents the diethyldithiocarbamate enhancement of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice.

  Brain research 20030530

• Glutathione depletion increases nitric oxide-induced oxidative stress in primary rat hepatocyte cultures: involvement of low-molecular-weight iron.

  Free radical biology & medicine 20030515

• Fos protein expression following acute administration of diethyldithiocarbamate in rats.

  Neuroscience letters 20030515

• Mechanisms of the protective action of diethyldithiocarbamate-iron complex on acute cardiac allograft rejection.

  American journal of physiology. Heart and circulatory physiology 20030501

• Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism.

  Archives of toxicology 20030501

• Triple vs. quadruple therapy for treating Helicobacter pylori infection: a meta-analysis.

  Alimentary pharmacology & therapeutics 20030501

• Inhibition of high K+-evoked gamma-aminobutyric acid release by sodium nitroprusside in rat hippocampus.

  European journal of pharmacology 20030425

• Tissue-engineered cartilage using an injectable and in situ gelable thermoresponsive gelatin: fabrication and in vitro performance.

  Tissue engineering 20030401

• Calretinin/PSA-NCAM immunoreactive granule cells after hippocampal damage produced by kainic acid and DEDTC treatment in mouse.

  Brain research 20030321

• Truffle thio-flavours reversibly inhibit truffle tyrosinase.

  FEMS microbiology letters 20030314

• Identification of the hydroxyl radical and other reactive oxygen species in human neutrophil granulocytes exposed to a fragment of the amyloid beta peptide.

  Free radical research 20030301

• Inhibition of Japanese encephalitis virus infection by diethyldithiocarbamate is independent of its antioxidant potential.

  Antiviral chemistry & chemotherapy 20030301

• Renal sympathetic nerve responses to tempol in spontaneously hypertensive rats.

  Hypertension (Dallas, Tex. : 1979) 20030201

• The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance.

  The British journal of dermatology 20030201

• Chemical modifications to study mutations that affect the ability of the general base (E268) to function in human liver mitochondrial aldehyde dehydrogenase.

  Chemico-biological interactions 20030201

• Role of superoxide anion in pancreatic islet blood flow regulation in anesthetized rats.

  European journal of pharmacology 20030110

• Zinc chelation during non-lesioning overexcitation results in neuronal death in the mouse hippocampus.

  Neuroscience 20030101

• Apoptosis in growing hair follicles following gamma-irradiation and application for the evaluation of radioprotective agents.

  In vivo (Athens, Greece) 20030101

• Kinetics of increased generation of (.)NO in endotoxaemic rats as measured by EPR.

  Acta biochimica Polonica 20030101

• DDTC, a metabolite of disulfiram, reduces the stimulating effect on ethanol's locomotor activity in mice.

  Psychopharmacology bulletin 20030101

• Fluorescence microplate assay for the detection of oxidative burst products in tobacco cell suspensions using 2',7'-dichlorofluorescein.

  Methods in cell science : an official journal of the Society for In Vitro Biology 20030101

• Intracellular superoxide induces apoptosis in VSMCs: role of mitochondrial membrane potential, cytochrome C and caspases.

  Apoptosis : an international journal on programmed cell death 20021201

• Effects of thymomimetic drugs and zinc supplementation on the cellular immune response in hydrocortisone-suppressed mice.

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20021201

• Angiotensin II induces a rapid and transient increase of reactive oxygen species.

  Antioxidants & redox signaling 20021201

• Inhibition of the microsomal metabolism of 1,8-cineole in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals.

  Xenobiotica; the fate of foreign compounds in biological systems 20021201

• Measurement of ascorbic acid (vitamin C) induced hydroxyl radical generation in household drinking water.

  Free radical research 20021201

• Do mast cells play any role in the pathogenesis of experimental pancreatic fibrosis in rats?

  Pancreas 20021101

• Postnatal maturation in nitric oxide-induced pulmonary artery relaxation involving cyclooxygenase-1 activity.

  American journal of physiology. Lung cellular and molecular physiology 20021001

• Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen.

  American journal of physiology. Heart and circulatory physiology 20021001

• Effect of the inhibition of the metabolism of 4-vinylphenol on its hepatotoxicity and pneumotoxicity in rats and mice.

  Toxicology 20020930

• Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells.

  The Biochemical journal 20020801

• Modulation of heat-induced cell death in PC-3 prostate cancer cells by the antioxidant inhibitor diethyldithiocarbamate.

  BJU international 20020801

• Evaluation of the cytotoxicity of polyetherurethane (PU) film containing zinc diethyldithiocarbamate (ZDEC) on various cell lines.

  Yonsei medical journal 20020801

• [Photometric determination of cobalt by the formation of a multi-ligand complex of Co(II)-C16H16N2S2O2-DEA].

  Guang pu xue yu guang pu fen xi = Guang pu 20020801

• Increased NADPH oxidase activity, gp91phox expression, and endothelium-dependent vasorelaxation during neointima formation in rabbits.

  Circulation research 20020712

• Effects of the dithiocarbamate fungicide propineb in primary neuronal cell cultures and skeletal muscle cells of the rat.

  Archives of toxicology 20020701

• Functional analysis of the copper-dependent quercetin 2,3-dioxygenase. 1. Ligand-induced coordination changes probed by X-ray crystallography: inhibition, ordering effect, and mechanistic insights.

  Biochemistry 20020625

• Sleep impairment by diethyldithiocarbamate in rat. Protective effects of pre-conditioning and antioxidants.

  Brain research 20020607

• Production of superoxide through NADH oxidase in thick ascending limb of Henle's loop in rat kidney.

  American journal of physiology. Renal physiology 20020601

• EPR characterization of the mononuclear Cu-containing Aspergillus japonicus quercetin 2,3-dioxygenase reveals dramatic changes upon anaerobic binding of substrates.

  European journal of biochemistry 20020601

• Change of Cu,Zn-superoxide dismutase activity of guinea pig lung in experimental asthma.

  Free radical research 20020601

• The effects of ebselen on cisplatin and diethyldithiocarbamate (DDC) cytotoxicity in rat hippocampal astrocytes.

  Toxicology letters 20020528

• Production of interleukin-6 by skeletal myotubes: role of reactive oxygen species.

  American journal of respiratory cell and molecular biology 20020501

• Microglia activation and cell death in response to diethyl-dithiocarbamate acute administration.

  The Journal of comparative neurology 20020429

• Peripheral 5-HT(2A)-receptor-mediated formation of an inhibitor of atrial natriuretic peptide binding involves inflammation.

  European journal of pharmacology 20020405

• Concurrent administration of diethyldithiocarbamate and 4-methylpyrazole enhances ethanol-induced locomotor activity: the role of brain ALDH.

  Psychopharmacology 20020401

• Effects of N-acetylcysteine in an esophageal carcinogenesis model in rats treated with diethylnitrosamine and diethyldithiocarbamate.

  International journal of cancer 20020401

• Reduction of toxic metabolite formation of acetaminophen.

  Biochemical and biophysical research communications 20020308

• Diethyldithiocarbamate inhibition of galactosamine-induced hepatitis in rats.

  Pharmacological research 20020301

• In vivo inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate.

  Indian journal of experimental biology 20020301

• Palmitate-induced apoptosis in neonatal cardiomyocytes is not dependent on the generation of ROS.

  American journal of physiology. Heart and circulatory physiology 20020201

• Nitric oxide blockade enhances renal responses to superoxide dismutase inhibition in dogs.

  Hypertension (Dallas, Tex. : 1979) 20020201

• Influence of antioxidant depletion on nitrergic relaxation in the pig gastric fundus.

  British journal of pharmacology 20020201

• Increased renal medullary oxidative stress produces hypertension.

  Hypertension (Dallas, Tex. : 1979) 20020201

• Effect of a high salt diet on microvascular antioxidant enzymes.

  Journal of vascular research 20020101

• [Poisoning by chromium and its long lasting detoxication].

  Medicina (Kaunas, Lithuania) 20020101

• Advanced spin trapping of vascular nitric oxide using colloid iron diethyldithiocarbamate.

  Methods in enzymology 20020101

• Influence of diethyldithiocarbamate on the activity of ecto-ATPase in lymphocytes of rats: ex vivo studies.

  Polish journal of pharmacology 20020101

• Sulfallate.

  Report on carcinogens : carcinogen profiles 20020101

• Effects of vanilloid receptor agonists and antagonists on gastric antral ulcers in rats.

  European journal of pharmacology 20011207

• Oxidative stress enhances the production and actions of adenosine in the kidney.

  American journal of physiology. Regulatory, integrative and comparative physiology 20011201

• ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species.

  American journal of physiology. Lung cellular and molecular physiology 20011101

• Nitric oxide donors retard wound healing in cultured rabbit gastric epithelial cell monolayers.

  American journal of physiology. Gastrointestinal and liver physiology 20011101

• Nitric oxide and iron overload. Limitations of ESR detection by DETC.

  Toxicology 20011030

• Use of the chemiluminescent probe lucigenin to monitor the production of the superoxide anion radical in a recombinant Aspergillus niger (B1-D).

  Biotechnology and bioengineering 20011020

• Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD.

  American journal of physiology. Heart and circulatory physiology 20011001

• Quantification of copper in biological materials by use of electron spin resonance.

  Clinical chemistry 20011001

• Volumetric and horseradish peroxidase tracing analysis of rat olfactory bulb following reversible olfactory nerve lesions.

  Chemical senses 20011001

• Chronic and cyclical neuronal loss in hippocampal slice cultures following transient inhibition of the type 1 isoform of superoxide dismutase.

  Brain research 20010921

• Effects of diethyldithiocarbamate on proliferation, redifferention, and apoptosis in human hepatoma cells.

  Acta pharmacologica Sinica 20010901

• Lipopolysaccharide and interferon-gamma-induced nitric oxide production and protein oxidation in mouse peritoneal macrophages are affected by glutathione peroxidase-1 gene knockout.

  Free radical biology & medicine 20010815

• Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process.

  Free radical biology & medicine 20010815

• Patch testing discordance alert: false-negative findings with rubber additives and fragrances.

  Journal of the American Academy of Dermatology 20010801

• 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca(2+) channel via superoxide anion generation.

  British journal of pharmacology 20010801

• Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.

  FEBS letters 20010706

• Pituitary adenylyl cyclase-activating peptides and alpha-amidation in olfactory neurogenesis and neuronal survival in vitro.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010701

• Activation of the nuclear factor-kappaB is a key event in brain tolerance.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010701

• Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway?

  Synapse (New York, N.Y.) 20010615

• The NF-kappaB inhibitor diethyldithiocarbamate (DDTC) increases brain cell death in a transient middle cerebral artery occlusion model of ischemia.

  Brain research bulletin 20010601

• Experimental evidence suggesting that nitric oxide diffuses from tissue into blood but not from blood into tissue.

  Biochimica et biophysica acta 20010531

• Antioxidants inhibit JNK and p38 MAPK activation but not ERK 1/2 activation by angiotensin II in rat aortic smooth muscle cells.

  Hypertension research : official journal of the Japanese Society of Hypertension 20010501

• Placental superoxide is increased in pre-eclampsia.

  Placenta 20010401

• Rat liver microsomal lipid peroxidation produced during the oxidative metabolism of ethacrynic acid.

  Pharmacology & toxicology 20010401

• Enhanced superoxide anion formation in vascular tissues from spontaneously hypertensive and desoxycorticosterone acetate-salt hypertensive rats.

  Journal of hypertension 20010401

• On-line preconcentration system using a packed-bed filter for the determination of lead in tap water by inductively coupled plasma atomic emission spectrometry with ultrasonic nebulization.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20010301

• Coprecipitation of trace metal ions in water with bismuth(III) diethyldithiocarbamate for an electrothermal atomic absorption spectrometric determination.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20010301

• Sodium nitroprusside-induced seizures and adenosine release in rat hippocampus.

  European journal of pharmacology 20010216

• Effects of sodium diethyldithiocarbamate on type II pulmonary epithelial cells in vitro.

  Journal of toxicology and environmental health. Part A 20010209

• Metabolism of a disulfiram metabolite, S-methyl N,N-diethyldithiocarbamate, by flavin monooxygenase in human renal microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20010201

• Production and actions of superoxide in the renal medulla.

  Hypertension (Dallas, Tex. : 1979) 20010201

• Overview--in vitro inhibition of aldehyde dehydrogenase by disulfiram and metabolites.

  Chemico-biological interactions 20010130

• In vivo inhibition of aldehyde dehydrogenase by disulfiram.

  Chemico-biological interactions 20010130

• Preventive effect of diethyldithiocarbamate on selenite-induced opacity in cultured rat lenses.

  Ophthalmic research 20010101

• Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts.

  American journal of physiology. Cell physiology 20010101

• Study on free radicals and pancreatic fibrosis--pancreatic fibrosis induced by repeated injections of superoxide dismutase inhibitor.

  Pancreas 20010101

• S-methyl-N,N-diethylthiocarbamate sulfoxide elicits neuroprotective effect against N-methyl-D-aspartate receptor-mediated neurotoxicity.

  Journal of biomedical science 20010101

• Oxygen metabolites in immune- stimulated ion transport in rat colon: modulation by taurine.

  Digestion 20010101

• Combined pulmonary toxicity of cadmium chloride and sodium diethyldithiocarbamate.

  Journal of applied toxicology : JAT 20010101

• Modification of radiation response in mice by Panax ginseng and diethyldithiocarbamate.

  In vivo (Athens, Greece) 20010101

• A Genetically engineered cell-based system for detecting metabolism-mediated toxicity.

  Alternatives to laboratory animals : ATLA 20010101

• Redox regulation of p53 during hypoxia.

  Oncogene 20000810

• Protective role of copper, zinc superoxide dismutase against UVB-induced injury of the human keratinocyte cell line HaCaT.

  The Journal of investigative dermatology 20000301

• Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression.

  Archives of toxicology 19990201

• Antiviral oligo- and polyribonucleotides containing selected triazolo[2,3-a]purines.

  Journal of medicinal chemistry 19981203

• Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus.

  The Journal of antimicrobial chemotherapy 19981201

• The detection of cytochrome P450 2E1 and its catalytic activity in rat testis.

  Biochemical and biophysical research communications 19980529

• Protective effect of diethyldithiocarbamate pretreatment on chromium (VI)-induced cytotoxicity and lipid peroxidation in primary cultures of rat hepatocytes.

  The Journal of veterinary medical science 19980101

• Zinc ejection as a new rationale for the use of cystamine and related disulfide-containing antiviral agents in the treatment of AIDS.

  Journal of medicinal chemistry 19970620

• Examination of purported probes of human CYP2B6.

  Pharmacogenetics 19970601

• Involvement of cytochrome P4502E1 in the toxicity of dichloropropanol to rat hepatocyte cultures.

  Toxicology 19970328

• Effect of diethyldithiocarbamate on Cryptosporidium parvum infection in immunosuppressed rats.

  The Journal of parasitology 19960201

• Differences in rates of benzene metabolism correlate with observed genotoxicity.

  Toxicology and applied pharmacology 19960101

• Drug interaction effects on antitumour drugs (XV): Disulfiram as protective agent against cyclophosphamide-induced urotoxicity without compromising antitumour activity in mice.

  Pharmacology & toxicology 19940101

• Effects of inhibition of catalase and superoxide dismutase activity on antioxidant enzyme mRNA levels.

  The American journal of physiology 19931201

• Regulation of cytochrome P450 2B1/2 genes by diallyl sulfone, disulfiram, and other organosulfur compounds in primary cultures of rat hepatocytes.

  Biochemical pharmacology 19930609

• Dominant role of cytochrome P-450 2E1 in human hepatic microsomal oxidation of the CFC-substitute 1,1,1,2-tetrafluoroethane.

  Drug metabolism and disposition: the biological fate of chemicals 19920101

• Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-on e (TIBO) derivatives. 2.

  Journal of medicinal chemistry 19911101

• Nephrotoxicity of paracetamol in the rat--mechanistic and therapeutic aspects.

  Journal of applied toxicology : JAT 19910401

• Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects.

  Chemical research in toxicology 19910101

• Cellular response after mobilization of metals by diethyldithiocarbamate in rat hepatocyte cultures.

  Toxicology 19901217

• Inhibition of HIV progression by dithiocarb. German DTC Study Group.

  Lancet (London, England) 19900324

• Methamphetamine-induced neuronal damage: a possible role for free radicals.

  Neuropharmacology 19891001

• Stress by restraining potentiates morphine catalepsy in rats.

  Experientia 19851215

• In-vitro inhibition of LAV/HTLV-III infected lymphocytes by dithiocarb and inosine pranobex.

  Lancet (London, England) 19851201

• Dose-response characteristics of various peptides with growth hormone-releasing activity in the unanesthetized male rat.

  Endocrinology 19850701

• The generation and regulation of human T lymphocytes by Imuthiol. Evidence from an in vitro differentiation induction system.

  International journal of immunopharmacology 19850101

• In vitro interaction of dithiocarb with rat liver glutathione S-transferases.

  Pharmacological research communications 19840201

• Central action of narcotic analgesics. Part III. The role of endogenous noradrenaline in hyperactivity induced by morphine or fentanyl in mice.

  Polish journal of pharmacology and pharmacy 19780101