14875-96-8 | Heme

Packsize	Purity	Availability	Price	Discounted Price
1mg	90%	in stock	$114.00	$80.00
5mg	90%	in stock	$237.00	$166.00
25mg	90%	in stock	$420.00	$294.00
50mg	90%	in stock	$796.00	$557.00
100mg	90%	in stock	$1,183.00	$828.00

Description

• Catalog Number: AE98135
• Chemical Name: Heme
• CAS Number: 14875-96-8
• Molecular Formula: C34H30FeN4O4
• Molecular Weight: 616.4873
• MDL Number: MFCD00870215
• SMILES: C=CC1=C(C)[C]2N3C1=CC1=C(C)C(=C4[N-]1[Fe+2]13N3C(=C4)C(=C([C]3C=C3[N-]1C(=C2)C(=C3C)C=C)C)CCC(=O)[O-])CCC(=O)[O-].[H+].[H+]

Computed Properties

• Complexity: 1010
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 43
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 8

Literature

• Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.

  Toxicology and applied pharmacology 20170415

• Anaerobic Heme Degradation: ChuY Is an Anaerobilin Reductase That Exhibits Kinetic Cooperativity.

  Biochemistry 20170214

• Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures.

  Toxicology and applied pharmacology 20161115

• Radical new paradigm for heme degradation in Escherichia coli O157:H7.

  Proceedings of the National Academy of Sciences of the United States of America 20161025

• The role of myoglobin degradation in nephrotoxicity after rhabdomyolysis.

  Chemico-biological interactions 20160825

• Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium.

  Toxicological sciences : an official journal of the Society of Toxicology 20160501

• An alternative reaction for heme degradation catalyzed by the Escherichia coli O157:H7 ChuS protein: Release of hematinic acid, tripyrrole and Fe(III).

  Journal of inorganic biochemistry 20160101

• Characterization of the Ala62Pro polymorphic variant of human cytochrome P450 1A1 using recombinant protein expression.

  Toxicology and applied pharmacology 20150615

• Key roles for tyrosine 10 in aβ-heme complexes and its relevance to oxidative stress.

  Chemical research in toxicology 20150316

• Nitration of Y10 in Aβ1-40: is it a compensatory reaction against oxidative/nitrative stress and Aβ aggregation?

  Chemical research in toxicology 20150316

• Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin.

  Proceedings of the National Academy of Sciences of the United States of America 20150217

• Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.

  The Journal of biological chemistry 20141024

• Structure of REV-ERBβ ligand-binding domain bound to a porphyrin antagonist.

  The Journal of biological chemistry 20140718

• Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21.

  Obesity (Silver Spring, Md.) 20140301

• Quinoline-pyrimidine hybrids: synthesis, antiplasmodial activity, SAR, and mode of action studies.

  Journal of medicinal chemistry 20140123

• The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide.

  Toxicology and applied pharmacology 20140101

• Protective action of antioxidants on hepatic damage induced by griseofulvin.

  TheScientificWorldJournal 20140101

• Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.

  Pharmacological research 20131001

• Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.

  European journal of medicinal chemistry 20130801

• A new way to degrade heme: the Mycobacterium tuberculosis enzyme MhuD catalyzes heme degradation without generating CO.

  The Journal of biological chemistry 20130405

• Aβ interacts with both the iron center and the porphyrin ring of heme: mechanism of heme's action on Aβ aggregation and disaggregation.

  Chemical research in toxicology 20130218

• Role of 15-hydroxyeicosatetraenoic acid in hemozoin-induced lysozyme release from human adherent monocytes.

  BioFactors (Oxford, England) 20130101

• Treatment with heme arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of Human primary aldosteronism.

  Free radical biology & medicine 20121215

• A new, simple method for the production of meat-curing pigment under optimised conditions using response surface methodology.

  Meat science 20121201

• Propylbenzmethylation at Val-1(α) markedly increases the tetramer stability of the PEGylated hemoglobin: a comparison with propylation at Val-1(α).

  Biochimica et biophysica acta 20121201

• Pleiotropic neuroprotective and metabolic effects of Actovegin's mode of action.

  Journal of the neurological sciences 20121115

• Allosteric communication between the pyridoxal 5'-phosphate (PLP) and heme sites in the H2S generator human cystathionine β-synthase.

  The Journal of biological chemistry 20121102

• Tryptophan tryptophylquinone biosynthesis: a radical approach to posttranslational modification.

  Biochimica et biophysica acta 20121101

• How do heme-protein sensors exclude oxygen? Lessons learned from cytochrome c', Nostoc puntiforme heme nitric oxide/oxygen-binding domain, and soluble guanylyl cyclase.

  Antioxidants & redox signaling 20121101

• Optical and magneto-optical activity of cytochrome bd from Geobacillus thermodenitrificans.

  Biochimica et biophysica acta 20121101

• Heme and heme biosynthesis intermediates induce heme oxygenase-1 and cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: different requirement for transcription factor nuclear factor erythroid- derived 2-like 2.

  Toxicological sciences : an official journal of the Society of Toxicology 20121101

• Human serum albumin-based peroxidase having an iron protoporphyrin IX in artificial heme pocket.

  Chemistry, an Asian journal 20121101

• Effect of quaternary structure change on the low-lying electronic states of the ferrous heme in deoxy-Hb studied by multi-frequency EPR.

  Journal of inorganic biochemistry 20121101

• Cadmium-induced apoptosis in the BJAB human B cell line: involvement of PKC/ERK1/2/JNK signaling pathways in HO-1 expression.

  Toxicology 20121028

• Identification of antischistosomal leads by evaluating bridged 1,2,4,5-tetraoxanes, alphaperoxides, and tricyclic monoperoxides.

  Journal of medicinal chemistry 20121025

• Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR).

  Biochemistry 20121023

• A label-free real time fluorometric assay for protease and inhibitor screening with a released heme.

  Chemical communications (Cambridge, England) 20121018

• Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy.

  The Journal of biological chemistry 20121012

• The role of the distal histidine in H2O2 activation and heme protection in both peroxidase and globin functions.

  The journal of physical chemistry. B 20121011

• Absorption by isolated ferric heme nitrosyl cations in vacuo.

  Angewandte Chemie (International ed. in English) 20121008

• Amino acid sequence of myoglobin from white-tailed deer (Odocoileus virginianus).

  Meat science 20121001

• Ligand binding, reactivity and biological activity of a distal pocket mutant of neuroglobin.

  International journal of biological macromolecules 20121001

• Identification of a haem domain in human soluble adenylate cyclase.

  Bioscience reports 20121001

• Influence of main channel structure on H(2)O(2) access to the heme cavity of catalase KatE of Escherichia coli.

  Archives of biochemistry and biophysics 20121001

• Bovine carbonyl lactoperoxidase structure at 2.0Å resolution and infrared spectra as a function of pH.

  The protein journal 20121001

• Analysis of the role of the Aspergillus niger aminolevulinic acid synthase (hemA) gene illustrates the difference between regulation of yeast and fungal haem- and sirohaem-dependent pathways.

  FEMS microbiology letters 20121001

• Heme modulates smooth muscle cell proliferation and migration via NADPH oxidase: a counter-regulatory role for heme oxygenase system.

  Atherosclerosis 20121001

• Disrupting the bimolecular binding of the haem-binding protein 5 (AtHBP5) to haem oxygenase 1 (HY1) leads to oxidative stress in Arabidopsis.

  Journal of experimental botany 20121001

• Structure of the haptoglobin-haemoglobin complex.

  Nature 20120920

• Functional importance of a pair of conserved glutamic acid residues and of Ca(2+) binding in the cbb(3)-type oxygen reductases from Rhodobacter sphaeroides and Vibrio cholerae.

  Biochemistry 20120918

• Mutation of Phe413 to Tyr in catalase KatE from Escherichia coli leads to side chain damage and main chain cleavage.

  Archives of biochemistry and biophysics 20120915

• Classical catalase: ancient and modern.

  Archives of biochemistry and biophysics 20120915

• The reaction mechanisms of heme catalases: an atomistic view by ab initio molecular dynamics.

  Archives of biochemistry and biophysics 20120915

• Why do bacteria use so many enzymes to scavenge hydrogen peroxide?

  Archives of biochemistry and biophysics 20120915

• Fungal catalases: function, phylogenetic origin and structure.

  Archives of biochemistry and biophysics 20120915

• Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin.

  Journal of molecular biology 20120914

• Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR).

  The Journal of biological chemistry 20120914

• Dissection of porphyrin-induced conformational dynamics in the heme biosynthesis enzyme ferrochelatase.

  Biochemistry 20120911

• A resonance Raman enhancement mechanism for axial vibrational modes in the pyridine adduct of myoglobin proximal cavity mutant (H93G).

  The journal of physical chemistry. B 20120906

• Melatonin attenuates hypochlorous acid-mediated heme destruction, free iron release, and protein aggregation in hemoglobin.

  Journal of pineal research 20120901

• A Ser residue influences the structure and stability of a Pro-kinked transmembrane helix dimer.

  Biochimica et biophysica acta 20120901

• Hypochlorous acid-induced heme damage of hemoglobin and its inhibition by flavonoids.

  Toxicology in vitro : an international journal published in association with BIBRA 20120901

• Structure, function, and assembly of heme centers in mitochondrial respiratory complexes.

  Biochimica et biophysica acta 20120901

• One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans.

  Biochimica et biophysica acta 20120901

• Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation.

  Molecular pharmacology 20120901

• Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme.

  Drug metabolism and disposition: the biological fate of chemicals 20120901

• Erythrocytes, leukocytes and platelets as a source of oxidative stress in chronic vascular diseases: detoxifying mechanisms and potential therapeutic options.

  Thrombosis and haemostasis 20120901

• Coordinated expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 and heme oxygenase 2: evidence for a regulatory link between glycolysis and heme catabolism.

  The Tohoku journal of experimental medicine 20120901

• Native N-terminus nitrophorin 2 from the kissing bug: similarities to and differences from NP2(D1A).

  Chemistry & biodiversity 20120901

• Octabromodiphenyl ether - porphyrogenicity after repeated administration to rats.

  International journal of occupational medicine and environmental health 20120901

• A multifunctional 5-aminolevulinic acid derivative induces erythroid differentiation of K562 human erythroleukemic cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120830

• Sulfur oxygenation in biomimetic non-heme iron-thiolate complexes.

  Dalton transactions (Cambridge, England : 2003) 20120828

• X-linked sideroblastic anemia due to carboxyl-terminal ALAS2 mutations that cause loss of binding to the β-subunit of succinyl-CoA synthetase (SUCLA2).

  The Journal of biological chemistry 20120817

• Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study.

  Antioxidants & redox signaling 20120815

• Iron metabolism in hepcidin1 knockout mice in response to phenylhydrazine-induced hemolysis.

  Blood cells, molecules & diseases 20120815

• Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase.

  Biochemistry 20120814

• 1,2,3-Triazole-heme interactions in cytochrome P450: functionally competent triazole-water-heme complexes.

  Biochemistry 20120814

• Tyrosine B10 triggers a heme propionate hydrogen bonding network loop with glutamine E7 moiety.

  Biochemical and biophysical research communications 20120810

• Why is the oxidation state of iron crucial for the activity of heme-dependent aldoxime dehydratase? A QM/MM study.

  The journal of physical chemistry. B 20120809

• Site E14 in hemoglobins and myoglobins: a key residue that affects hemin loss and lipid oxidation capacity.

  Journal of agricultural and food chemistry 20120808

• Interaction between the heme and a G-quartet in a heme-DNA complex.

  Inorganic chemistry 20120806

• Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration.

  The Journal of biological chemistry 20120803

• Functional consequence of positive selection revealed through rational mutagenesis of human myeloperoxidase.

  Molecular biology and evolution 20120801

• Crystallographic studies of heme oxygenase complexed with an unstable reaction intermediate, verdoheme.

  Journal of inorganic biochemistry 20120801

• Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials.

  European journal of medicinal chemistry 20120801

• Assignment of the 1H NMR resonances of protein residues in close proximity to the heme of the nitrophorins: similarities and differences among the four proteins from the saliva of the adult blood-sucking insect Rhodnius prolixus.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20120801

• Clocks, metabolism, and the epigenome.

  Molecular cell 20120727

• Self-assembled monolayers of Aβ peptides on Au electrodes: an artificial platform for probing the reactivity of redox active metals and cofactors relevant to Alzheimer's disease.

  Journal of the American Chemical Society 20120725

• Chemical rescue of the distal histidine mutants of tryptophan 2,3-dioxygenase.

  Journal of the American Chemical Society 20120725

• Influence of heme post-translational modification and distal ligation on the backbone dynamics of a monomeric hemoglobin.

  Biochemistry 20120724

• The crystal structure of human α(1)-microglobulin reveals a potential haem-binding site.

  The Biochemical journal 20120715

• Horse heart cytochrome c entrapped into the hydrated liquid-crystalline phases of phytantriol: X-ray diffraction and Raman spectroscopic characterization.

  Journal of colloid and interface science 20120715

• Is histidine dissociation a critical component of the NO/H-NOX signaling mechanism? Insights from X-ray absorption spectroscopy.

  Dalton transactions (Cambridge, England : 2003) 20120714

• Changes in the heme ligation during folding of a Geobacter sulfurreducens sensor GSU0935.

  Dalton transactions (Cambridge, England : 2003) 20120714

• A heme degradation enzyme, HutZ, from Vibrio cholerae.

  Chemical communications (Cambridge, England) 20120707

• The crystal structure of the extracellular 11-heme cytochrome UndA reveals a conserved 10-heme motif and defined binding site for soluble iron chelates.

  Structure (London, England : 1993) 20120703

• Enzyme or electrode?

  Structure (London, England : 1993) 20120703

• Dietary haem stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon.

  Gut 20120701

• Non-invasive evaluation of vasomotor and metabolic functions of microvascular endothelium in human skin.

  Microvascular research 20120701

• Impairment of heme biosynthesis induces short circadian period in body temperature rhythms in mice.

  American journal of physiology. Regulatory, integrative and comparative physiology 20120701

• Evaluation of unbound free heme in plant cells by differential acetone extraction.

  Plant & cell physiology 20120701

• Structural dynamics of proximal heme pocket in HemAT-Bs associated with oxygen dissociation.

  Biochimica et biophysica acta 20120701

• Aryl aryl methyl thio arenes prevent multidrug-resistant malaria in mouse by promoting oxidative stress in parasites.

  Free radical biology & medicine 20120701

• Heme carrier protein 1 transports heme and is involved in heme-Fe metabolism.

  American journal of physiology. Cell physiology 20120615

• Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.

  Journal of medicinal chemistry 20120614

• Exploration of the binding of curcumin analogues to human P450 2C9 based on docking and molecular dynamics simulation.

  Journal of molecular modeling 20120601

• Heme induced oxidative stress attenuates sirtuin1 and enhances adipogenesis in mesenchymal stem cells and mouse pre-adipocytes.

  Journal of cellular biochemistry 20120601

• 2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.

  European journal of medicinal chemistry 20120601

• Heme A biosynthesis.

  Biochimica et biophysica acta 20120601

• Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways.

  Archives of toxicology 20120601

• Acute intermittent porphyria: fatal complications of treatment.

  Clinical medicine (London, England) 20120601

• Inhibition and inactivation of cytochrome P450 2A6 and cytochrome P450 2A13 by menthofuran, β-nicotyrine and menthol.

  Chemico-biological interactions 20120530

• Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.

  Chemical research in toxicology 20120521

• Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase.

  The Journal of biological chemistry 20120511

• Nitric oxide regulated two-component signaling in Pseudoalteromonas atlantica.

  Biochemical and biophysical research communications 20120511

• Modeling and computations of the intramolecular electron transfer process in the two-heme protein cytochrome c(4).

  Physical chemistry chemical physics : PCCP 20120507

• Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat.

  Chembiochem : a European journal of chemical biology 20120507

• Unveiling the three-dimensional structure of the green pigment of nitrite-cured meat.

  Chemical communications (Cambridge, England) 20120504

• Photo-induced electron transfer in intact cells of Rubrivivax gelatinosus mutants deleted in the RC-bound tetraheme cytochrome: insight into evolution of photosynthetic electron transport.

  Biochimica et biophysica acta 20120501

• Tyrosine triad at the interface between the Rieske iron-sulfur protein, cytochrome c1 and cytochrome c2 in the bc1 complex of Rhodobacter capsulatus.

  Biochimica et biophysica acta 20120501

• An investigation of the catalytic activity of CYP2A13*4 with coumarin and polymorphisms of CYP2A13 in a Chinese Han population.

  Drug metabolism and disposition: the biological fate of chemicals 20120501

• The 18 kDa mitochondrial translocator protein (TSPO) prevents accumulation of protoporphyrin IX. Involvement of reactive oxygen species (ROS).

  Current molecular medicine 20120501

• Elucidating second coordination sphere effects in heme proteins using low-temperature magnetic circular dichroism spectroscopy.

  Journal of inorganic biochemistry 20120501

• Guanidine-ferroheme coordination in the mutant protein nitrophorin 4(L130R).

  Angewandte Chemie (International ed. in English) 20120427

• PpsR, a regulator of heme and bacteriochlorophyll biosynthesis, is a heme-sensing protein.

  The Journal of biological chemistry 20120420

• ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity.

  The Journal of biological chemistry 20120413

• Absorption band III kinetics probe the picosecond heme iron motion triggered by nitric oxide binding to hemoglobin and myoglobin.

  The journal of physical chemistry. B 20120405

• Mechanism of binding of NO to soluble guanylyl cyclase: implication for the second NO binding to the heme proximal site.

  Biochemistry 20120403

• Detection, characterization, and screening of heme-binding molecules by mass spectrometry for malaria drug discovery.

  Analytical chemistry 20120403

• Dynamics comparison of two myoglobins with a distinct heme active site.

  Journal of molecular modeling 20120401

• The origin of the Fe(IV)=O intermediates in cytochrome aa(3) oxidase.

  Biochimica et biophysica acta 20120401

• Molecular structure and function of bacterial nitric oxide reductase.

  Biochimica et biophysica acta 20120401

• Binding free energies of inhibitors to iron porphyrin complex as a model for Cytochrome P450.

  Biopolymers 20120401

• Structural studies on bovine heart cytochrome c oxidase.

  Biochimica et biophysica acta 20120401

• Urine heme dipsticks are useful in monitoring the impact of praziquantel treatment on Schistosoma haematobium in sentinel communities of Delta State, Nigeria.

  Acta tropica 20120401

• The dehaloperoxidase paradox.

  Biochimica et biophysica acta 20120401

• Surrogate genetics and metabolic profiling for characterization of human disease alleles.

  Genetics 20120401

• No effect of intravenous Actovegin® on peak aerobic capacity.

  International journal of sports medicine 20120401

• Synthesis and biological evaluation of acridine derivatives as antimalarial agents.

  ChemMedChem 20120401

• Heme-containing dioxygenases involved in tryptophan oxidation.

  Current opinion in chemical biology 20120401

• New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae).

  Experimental parasitology 20120401

• Concomitant induction of heme oxygenase-1 attenuates the cytotoxicity of arsenic species from lumbricus extract in human liver HepG2 cells.

  Chemistry & biodiversity 20120401

• Distal heme pocket residues of B-type dye-decolorizing peroxidase: arginine but not aspartate is essential for peroxidase activity.

  The Journal of biological chemistry 20120323

• Ultrafast dynamics of nonequilibrium resonance energy transfer and probing globular protein flexibility of myoglobin.

  The journal of physical chemistry. A 20120322

• Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)).

  Biochemistry 20120313

• Recent advances in cytochrome bc(1): inter monomer electronic communication?

  FEBS letters 20120309

• Redox active molecules cytochrome c and vitamin C enhance heme-enzyme peroxidations by serving as non-specific agents for redox relay.

  Biochemical and biophysical research communications 20120309

• Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.

  Blood 20120308

• Ruthenium(II) arene complexes with chelating chloroquine analogue ligands: synthesis, characterization and in vitro antimalarial activity.

  Dalton transactions (Cambridge, England : 2003) 20120307

• Measurement of the mitochondrial membrane potential and pH gradient from the redox poise of the hemes of the bc1 complex.

  Biophysical journal 20120307

• Isolation and characterization of free haem from the shell gland of quail and hen.

  Biomedical chromatography : BMC 20120301

• Can an iron-rich staple food help women to achieve dietary targets in pregnancy?

  International journal of food sciences and nutrition 20120301

• Leu65 in the heme distal side is critical for the stability of the Fe(II)-O2 complex of YddV, a globin-coupled oxygen sensor diguanylate cyclase.

  Journal of inorganic biochemistry 20120301

• Treatment with Actovegin® improves sensory nerve function and pathology in streptozotocin-diabetic rats via mechanisms involving inhibition of PARP activation.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20120301

• Heterologous production and characterisation of two distinct dihaem-containing membrane integral cytochrome b(561) enzymes from Arabidopsis thaliana in Pichia pastoris and Escherichia coli cells.

  Biochimica et biophysica acta 20120301

• Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals.

  Drug metabolism and disposition: the biological fate of chemicals 20120301

• Binding of cysteine thiolate to the Fe(III) heme complex is critical for the function of heme sensor proteins.

  Journal of inorganic biochemistry 20120301

• Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20120301

• Cobinamides are novel coactivators of nitric oxide receptor that target soluble guanylyl cyclase catalytic domain.

  The Journal of pharmacology and experimental therapeutics 20120301

• Heme oxygenases from Arabidopsis thaliana reveal different mechanisms of carbon monoxide binding.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120301

• Effects of the bHLH domain on axial coordination of heme in the PAS-A domain of neuronal PAS domain protein 2 (NPAS2): conversion from His119/Cys170 coordination to His119/His171 coordination.

  Journal of inorganic biochemistry 20120301

• δ-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva.

  European journal of cell biology 20120301

• Differential function of lip residues in the mechanism and biology of an anthrax hemophore.

  PLoS pathogens 20120301

• Hydroxylation of aromatics with the help of a non-haem FeOOH: a mechanistic study under single-turnover and catalytic conditions.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20120227

• Proline 107 is a major determinant in maintaining the structure of the distal pocket and reactivity of the high-spin heme of MauG.

  Biochemistry 20120227

• Distinct roles of isoforms of the heme-liganded nuclear receptor E75, an insect ortholog of the vertebrate Rev-erb, in mosquito reproduction.

  Molecular and cellular endocrinology 20120226

• Quaternary structure controls ligand dynamics in soluble guanylate cyclase.

  The Journal of biological chemistry 20120224

• Fluorescence detection of ligand binding to labeled cytochrome P450 BM3.

  Dalton transactions (Cambridge, England : 2003) 20120221

• Zinc-substituted cytochrome P450cam: characterization of protein conformers F420 and F450 by photoinduced electron transfer.

  Biochemistry 20120221

• Characterization of heme ligation properties of Rv0203, a secreted heme binding protein involved in Mycobacterium tuberculosis heme uptake.

  Biochemistry 20120221

• The mechanism of substrate inhibition in human indoleamine 2,3-dioxygenase.

  Journal of the American Chemical Society 20120215

• The membrane modulates internal proton transfer in cytochrome c oxidase.

  Biochemistry 20120214

• Topologically conserved residues direct heme transport in HRG-1-related proteins.

  The Journal of biological chemistry 20120210

• Inherently distorted heme as a novel tool for myoglobin-based oxygen carrier.

  Artificial organs 20120201

• Caffeine inhibits erythrocyte membrane derangement by antioxidant activity and by blocking caspase 3 activation.

  Biochimie 20120201

• Haem oxygenase-1: non-canonical roles in physiology and pathology.

  Clinical science (London, England : 1979) 20120201

• Heme breakdown and ischemia/reperfusion injury in grafted liver during living donor liver transplantation.

  International journal of molecular medicine 20120201

• Enhancement of nitrite on heme-induced oxidative reactions: A potential toxicological implication.

  Toxicology in vitro : an international journal published in association with BIBRA 20120201

• The role of a disulfide bridge in the stability and folding kinetics of Arabidopsis thaliana cytochrome c(6A).

  Biochimica et biophysica acta 20120201

• Therapeutic potential of carbon monoxide in multiple sclerosis.

  Clinical and experimental immunology 20120201

• Heme flattening is sufficient for signal transduction in the H-NOX family.

  Journal of the American Chemical Society 20120201

• A distal pocket Leu residue inhibits the binding of O2 and NO at the distal heme site of cytochrome c'.

  Journal of the American Chemical Society 20120125

• Mechanistic investigation of cyclohexane oxidation by a non-heme iron complex: evidence of product inhibition by UV/vis stopped-flow studies.

  Dalton transactions (Cambridge, England : 2003) 20120121

• Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulation.

  Circulation research 20120120

• A pivotal heme-transfer reaction intermediate in cytochrome c biogenesis.

  The Journal of biological chemistry 20120120

• Traces of certain drug molecules can enhance heme-enzyme catalytic outcomes.

  Biochemical and biophysical research communications 20120120

• Quantum mechanically derived AMBER-compatible heme parameters for various states of the cytochrome P450 catalytic cycle.

  Journal of computational chemistry 20120115

• Prediction of sites of metabolism in a substrate molecule, instanced by carbamazepine oxidation by CYP3A4.

  Bioorganic & medicinal chemistry 20120115

• Solution behavior of iron(III) and iron(II) porphyrins in DMSO and reaction with superoxide. Effect of neighboring positive charge on thermodynamics, kinetics and nature of iron-(su)peroxo product.

  Dalton transactions (Cambridge, England : 2003) 20120114

• Activating transcription factor 1 directs Mhem atheroprotective macrophages through coordinated iron handling and foam cell protection.

  Circulation research 20120106

• Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.

  The Journal of biological chemistry 20120106

• Physiological responses to temperature and haeme synthesis modifiers in earthworm Lumbricus terrestris (Annelida: Oligochaeta).

  Environmental toxicology 20120101

• Isolation and characterization of a heme oxygenase-1 gene from Chinese cabbage.

  Molecular biotechnology 20120101

• Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice.

  Biotechnology advances 20120101

• Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases.

  Journal of inorganic biochemistry 20120101

• Extracellular heme enhances the antimalarial activity of artemisinin.

  Biological & pharmaceutical bulletin 20120101

• Novel transporter required for biogenesis of cbb3-type cytochrome c oxidase in Rhodobacter capsulatus.

  mBio 20120101

• A putative P-type ATPase required for virulence and resistance to haem toxicity in Listeria monocytogenes.

  PloS one 20120101

• Motion and flexibility in human cytochrome p450 aromatase.

  PloS one 20120101

• Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase.

  PloS one 20120101

• Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage.

  Journal of neuroinflammation 20120101

• Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs.

  PloS one 20120101

• Biological activities of nitidine, a potential anti-malarial lead compound.

  Malaria journal 20120101

• Renal failure affects the enzymatic activities of the three first steps in hepatic heme biosynthesis in the acute intermittent porphyria mouse.

  PloS one 20120101

• Interactions between amyloid-β and hemoglobin: implications for amyloid plaque formation in Alzheimer's disease.

  PloS one 20120101

• Heme mediated STAT3 activation in severe malaria.

  PloS one 20120101

• Cytochrome C as an amplifier of ROS release in mitochondria.

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20120101

• Genes important for catalase activity in Enterococcus faecalis.

  PloS one 20120101

• [The changes of metabolism in myocardium at ischemia-reperfusion and activating of the ATP-sensitive potassium channels].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20120101

• Direct heme transfer reactions in the Group A Streptococcus heme acquisition pathway.

  PloS one 20120101

• Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials.

  Molecular medicine (Cambridge, Mass.) 20120101

• [Carbohydrate and nitrogenous metabolism condition in the rat tissue under experimental rhabdomyolysis].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20120101

• Heme degrading protein HemS is involved in oxidative stress response of Bartonella henselae.

  PloS one 20120101

• The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal.

  PloS one 20120101

• Structural insight into the substrate- and dioxygen-binding manner in the catalytic cycle of rieske nonheme iron oxygenase system, carbazole 1,9a-dioxygenase.

  BMC structural biology 20120101

• Heme arginate improves reperfusion patterns after ischemia: a randomized, placebo-controlled trial in healthy male subjects.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20120101

• Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection.

  PloS one 20120101

• [Peripheral mechanisms of action of oxatriazolium-5-olate derivative 3-(3-[1,2,4]-triazolo)oxatriazolium-5-olate in spontaneously hypertensive rats].

  Eksperimental'naia i klinicheskaia farmakologiia 20120101

• Influence of halogen substituents on the catalytic oxidation of 2,4,6-halogenated phenols by Fe(III)-tetrakis(p-hydroxyphenyl) porphyrins and potassium monopersulfate.

  Molecules (Basel, Switzerland) 20111222

• A highly reactive mononuclear non-heme manganese(IV)-oxo complex that can activate the strong C-H bonds of alkanes.

  Journal of the American Chemical Society 20111221

• Heme ligand identification and redox properties of the cytochrome c synthetase, CcmF.

  Biochemistry 20111220

• Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization.

  Nature medicine 20111218

• Dynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitization.

  The Journal of biological chemistry 20111216

• Probing a complex of cytochrome c and cardiolipin by magnetic circular dichroism spectroscopy: implications for the initial events in apoptosis.

  Journal of the American Chemical Society 20111214

• Oxygen-independent alkane formation by non-heme iron-dependent cyanobacterial aldehyde decarbonylase: investigation of kinetics and requirement for an external electron donor.

  Biochemistry 20111213

• 14-3-3 binding and phosphorylation of neuroglobin during hypoxia modulate six-to-five heme pocket coordination and rate of nitrite reduction to nitric oxide.

  The Journal of biological chemistry 20111209

• Red meat consumption and risk of heart failure in male physicians.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20111201

• Another look at the interaction between mitochondrial cytochrome c and flavocytochrome b (2).

  European biophysics journal : EBJ 20111201

• A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20111201

• Heme-mediated binding of α-casein to ferritin: evidence for preferential α-casein binding to ferrous iron.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20111201

• Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells.

  Molecular and cellular biochemistry 20111201

• Redox-based thrombelastographic method to detect carboxyhemefibrinogen-mediated hypercoagulability.

  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20111201

• Purple pigments: the pathophysiology of acute porphyric neuropathy.

  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20111201

• CodY regulation is required for full virulence and heme iron acquisition in Bacillus anthracis.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111201

• RNA and DNA complexes with hemin [Fe(III) heme] are efficient peroxidases and peroxygenases: how do they do it and what does it mean?

  Critical reviews in biochemistry and molecular biology 20111201

• Manipulating the proximal triad His-Asn-Arg in human myeloperoxidase.

  Archives of biochemistry and biophysics 20111201

• Nitration of tyrosines 46 and 48 induces the specific degradation of cytochrome c upon change of the heme iron state to high-spin.

  Biochimica et biophysica acta 20111201

• Neuroprotective and anti-oxidative effects of the hemodialysate actovegin on primary rat neurons in vitro.

  Neuromolecular medicine 20111201

• Heme arginate potentiates latent HIV-1 reactivation while inhibiting the acute infection.

  Antiviral research 20111201

• Carbon monoxide and nitric oxide modulate α₂-antiplasmin and plasmin activity: role of heme.

  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20111201

• A heme peroxidase of the ascomyceteous lichen Leptogium saturninum oxidizes high-redox potential substrates.

  Fungal genetics and biology : FG & B 20111201

• Faster heme loss from hemoglobin E than HbS, in acidic pH: effect of aminophospholipids.

  Journal of biosciences 20111201

• An Arabidopsis GluTR binding protein mediates spatial separation of 5-aminolevulinic acid synthesis in chloroplasts.

  The Plant cell 20111201

• Femtosecond UV studies of the electronic relaxation processes in Cytochrome c.

  The journal of physical chemistry. B 20111124

• Ferrochelatase catalyzes the formation of Zn-protoporphyrin of dry-cured ham via the conversion reaction from heme in meat.

  Journal of agricultural and food chemistry 20111123

• The conserved Trp-Cys hydrogen bond dampens the 'push effect' of the heme cysteinate proximal ligand during the first catalytic cycle of nitric oxide synthase.

  Biochemistry 20111122

• Probing the dynamics of a His73-heme alkaline transition in a destabilized variant of yeast iso-1-cytochrome c with conformationally gated electron transfer methods.

  Biochemistry 20111122

• 4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron.

  Chemical research in toxicology 20111121

• Isolated Hb Providence β82Asn and β82Asp fractions are more stable than native HbA(0) under oxidative stress conditions.

  Biochemistry 20111115

• Cytochrome c(552) from Thermus thermophilus engineered for facile substitution of prosthetic group.

  Biochemistry 20111115

• Influence of heme-thiolate in shaping the catalytic properties of a bacterial nitric-oxide synthase.

  The Journal of biological chemistry 20111111

• Aldoxime dehydratase: probing the heme environment involved in the synthesis of the carbon-nitrogen triple bond.

  The journal of physical chemistry. B 20111110

• Direct observation of vibrational energy flow in cytochrome c.

  The journal of physical chemistry. B 20111110

• Molecular hijacking of siroheme for the synthesis of heme and d1 heme.

  Proceedings of the National Academy of Sciences of the United States of America 20111108

• Gd(III) chelates as NMR probes of protein-protein interactions. Case study: rubredoxin and cytochrome c3.

  Inorganic chemistry 20111107

• Strong ligand-protein interactions revealed by ultrafast infrared spectroscopy of CO in the heme pocket of the oxygen sensor FixL.

  Journal of the American Chemical Society 20111102

• Molecular enzymology of 5-aminolevulinate synthase, the gatekeeper of heme biosynthesis.

  Biochimica et biophysica acta 20111101

• Predicting the functionally distinct residues in the heme, cation, and substrate-binding sites of peroxidase from stress-tolerant mangrove specie, Avicennia marina.

  Cell stress & chaperones 20111101

• Drugs in porphyria: From observation to a modern algorithm-based system for the prediction of porphyrogenicity.

  Pharmacology & therapeutics 20111101

• Oxidative stress modulates heme synthesis and induces peroxiredoxin-2 as a novel cytoprotective response in β-thalassemic erythropoiesis.

  Haematologica 20111101

• Stereoselective oxidation of regioisomeric octadecenoic acids by fatty acid dioxygenases.

  Journal of lipid research 20111101

• Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme.

  Molecular pharmacology 20111101

• Heme induces heme oxygenase 1 via Nrf2: role in the homeostatic macrophage response to intraplaque hemorrhage.

  Arteriosclerosis, thrombosis, and vascular biology 20111101

• Sampangine inhibits heme biosynthesis in both yeast and human.

  Eukaryotic cell 20111101

• The effects of ATP and sodium chloride on the cytochrome c-cardiolipin interaction: the contrasting behavior of the horse heart and yeast proteins.

  Journal of inorganic biochemistry 20111101

• Cytochrome c maturation system on the negative side of bioenergetic membranes: CCB or System IV.

  The FEBS journal 20111101

• Composition and function of cytochrome c biogenesis System II.

  The FEBS journal 20111101

• Reduction of the lipocalin type heme containing protein nitrophorin -- sensitivity of the fold-stabilizing cysteine disulfides toward routine heme-iron reduction.

  Journal of inorganic biochemistry 20111101

• Cytochrome c biogenesis System I.

  The FEBS journal 20111101

• Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.

  Investigative ophthalmology & visual science 20111101

• Iron-coordinating tyrosine is a key determinant of NEAT domain heme transfer.

  Journal of molecular biology 20111028

• 5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes.

  The Journal of biological chemistry 20111028

• A heme peroxidase with a functional role as an L-tyrosine hydroxylase in the biosynthesis of anthramycin.

  Biochemistry 20111018

• Role of VPO1, a newly identified heme-containing peroxidase, in ox-LDL induced endothelial cell apoptosis.

  Free radical biology & medicine 20111015

• Identification and functional and spectral characterization of a globin-coupled histidine kinase from Anaeromyxobacter sp. Fw109-5.

  The Journal of biological chemistry 20111014

• Direct spectroscopic evidence for binding of anastrozole to the iron heme of human aromatase. Peering into the mechanism of aromatase inhibition.

  Chemical communications (Cambridge, England) 20111014

• Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.

  Journal of medicinal chemistry 20111013

• The mechanism of formation of N-formylkynurenine by heme dioxygenases.

  Journal of the American Chemical Society 20111012

• Breaking the proximal Fe(II)-N(His) bond in heme proteins through local structural tension: lessons from the heme b proteins nitrophorin 4, nitrophorin 7, and related site-directed mutant proteins.

  Biochemistry 20111011

• Proton delivery to ferryl heme in a heme peroxidase: enzymatic use of the Grotthuss mechanism.

  Journal of the American Chemical Society 20111005

• Heme-Cu bound aβ peptides: spectroscopic characterization, reactivity, and relevance to Alzheimer's disease.

  Journal of the American Chemical Society 20111005

• Crystallographic trapping of heme loss intermediates during the nitrite-induced degradation of human hemoglobin.

  Biochemistry 20111004

• Reversible heme-dependent regulation of human cystathionine β-synthase by a flavoprotein oxidoreductase.

  Biochemistry 20111004

• Electron transfer pathways in cytochrome c oxidase.

  Biochimica et biophysica acta 20111001

• The D-channel of cytochrome oxidase: an alternative view.

  Biochimica et biophysica acta 20111001

• Hemoglobin-albumin crosslinked copolymers: reduced prooxidant reactivity.

  Artificial cells, blood substitutes, and immobilization biotechnology 20111001

• Isotopic labeling of the heme cofactor in cytochrome P450 and other heme proteins.

  Biotechnology letters 20111001

• Differential effects of glutamate-286 mutations in the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides and the cytochrome bo(3) ubiquinol oxidase from Escherichia coli.

  Biochimica et biophysica acta 20111001

• Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation.

  Haematologica 20111001

• Radical formation in cytochrome c oxidase.

  Biochimica et biophysica acta 20111001

• Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidised sGC.

  Atherosclerosis 20111001

• Functional significance of the ATP-binding cassette transporter B6 in hepatocellular carcinoma.

  Molecular oncology 20111001

• The ground states of iron(III) porphines: role of entropy-enthalpy compensation, Fermi correlation, dispersion, and zero-point energies.

  Journal of inorganic biochemistry 20111001

• Heme binding in gas-phase holo-myoglobin cations: distal becomes proximal?

  Journal of the American Society for Mass Spectrometry 20111001

• Solution-based structural analysis of the decaheme cytochrome, MtrA, by small-angle X-ray scattering and analytical ultracentrifugation.

  The journal of physical chemistry. B 20110929

• The five near-iron transporter (NEAT) domain anthrax hemophore, IsdX2, scavenges heme from hemoglobin and transfers heme to the surface protein IsdC.

  The Journal of biological chemistry 20110923

• Pulsed ENDOR determination of relative orientation of g-frame and molecular frame of imidazole-coordinated heme center of iNOS.

  The journal of physical chemistry. A 20110922

• Precise design of artificial cofactors for enhancing peroxidase activity of myoglobin: myoglobin mutant H64D reconstituted with a 'single-winged cofactor' is equivalent to native horseradish peroxidase in oxidation activity.

  Chemistry, an Asian journal 20110905

• Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes.

  Biochimica et biophysica acta 20110901

• Dynamics of heme in hemoproteins: proton NMR study of myoglobin reconstituted with iron 3-ethyl-2-methylporphyrin.

  Biochimica et biophysica acta 20110901

• eNOS activation and NO function: differential control of steroidogenesis by nitric oxide and its adaptation with hypoxia.

  The Journal of endocrinology 20110901

• EPR investigation of the role of B10 phenylalanine in neuroglobin - evidence that B10Phe mediates structural changes in the heme region upon disulfide-bridge formation.

  Journal of inorganic biochemistry 20110901

• The neurologic manifestations of the acute porphyrias.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20110901

• NMR studies of nitrophorin distal pocket side chain effects on the heme orientation and seating of NP2 as compared to NP1.

  Journal of inorganic biochemistry 20110901

• Experimental and computational investigations of oxygen reactivity in a heme and tyrosyl radical-containing fatty acid α-(di)oxygenase.

  Biochemistry 20110830

• C-H bond activation of methanol and ethanol by a high-spin Fe(IV)O biomimetic complex.

  Angewandte Chemie (International ed. in English) 20110829

• Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.

  Biochemistry 20110823

• Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation, a novel mechanism regulating eNOS function and coupling.

  The Journal of biological chemistry 20110819

• Effect of solution viscosity on intraprotein electron transfer between the FMN and heme domains in inducible nitric oxide synthase.

  FEBS letters 20110819

• Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.

  Nature 20110817

• The effects of nitrogen-heme-iron coordination on substrate affinities for cytochrome P450 2E1.

  Chemico-biological interactions 20110815

• Structural stability and heme binding potential of the truncated human dual oxidase 2 (DUOX2) peroxidase domain.

  Archives of biochemistry and biophysics 20110815

• Porphyrogenic effect of pentabromodiphenyl ether after repeated administration to rats.

  Archives of toxicology 20110801

• δ-Aminolevulinic acid dehydratase genotype predicts toxic effects of lead on workers' peripheral nervous system.

  Neurotoxicology 20110801

• Heme biosynthesis and its regulation: towards understanding and improvement of heme biosynthesis in filamentous fungi.

  Applied microbiology and biotechnology 20110801

• Redox potentials of oxoiron(IV) porphyrin π-cation radical complexes: participation of electron transfer process in oxygenation reactions.

  Inorganic chemistry 20110801

• A simple method for enrichment of polychromatic erythroblasts from rat bone marrow, and their proliferation and maturation in vitro.

  The Journal of toxicological sciences 20110801

• Crystal structure of the heme d1 biosynthesis enzyme NirE in complex with its substrate reveals new insights into the catalytic mechanism of S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferases.

  The Journal of biological chemistry 20110729

• Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells.

  The Journal of biological chemistry 20110729

• Iron(III) mesoporphyrin IX and iron(III) deuteroporphyrin IX bind to the Porphyromonas gingivalis HmuY hemophore.

  Biochemical and biophysical research communications 20110729

• Effects of storage atmosphere and heme state on the color and visible reflectance spectra of salmon ( Salmo salar ) fillets.

  Journal of agricultural and food chemistry 20110727

• Ibuprofen and warfarin modulate allosterically ferrous human serum heme-albumin nitrosylation.

  Biochemical and biophysical research communications 20110722

• Mapping the iron binding site(s) on the small tetraheme cytochrome of Shewanella oneidensis MR-1.

  Biochemistry 20110719

• Insights into structure and function of the active site of SoxAX cytochromes.

  The Journal of biological chemistry 20110715

• Mimicking heme enzymes in the solid state: metal-organic materials with selectively encapsulated heme.

  Journal of the American Chemical Society 20110713

• Spectroscopic characterization of mononitrosyl complexes in heme--nonheme diiron centers within the myoglobin scaffold (Fe(B)Mbs): relevance to denitrifying NO reductase.

  Biochemistry 20110705

• Oxidation and loss of heme in soluble guanylyl cyclase from Manduca sexta.

  Biochemistry 20110705

• Cation modulation of hemoglobin interaction with sodium n-dodecyl sulfate (SDS). I: Calcium modulation at pH 7.20.

  Cell biochemistry and biophysics 20110701

• Higher order organization of human placental aromatase.

  Steroids 20110701

• Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction.

  Drug metabolism and disposition: the biological fate of chemicals 20110701

• Fibrinogen is a heme-associated, carbon monoxide sensing molecule: a preliminary report.

  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20110701

• Co-administration of meso 2,3-dimercaptosuccinic acid monoesters reduces arsenic concentration and oxidative stress in gallium arsenide exposed rats.

  Clinical and experimental pharmacology & physiology 20110701

• Molecular dynamics simulation of carboxy and deoxy human cytoglobin in solution.

  Journal of inorganic biochemistry 20110701

• The catalytic mechanism of dye-decolorizing peroxidase DyP may require the swinging movement of an aspartic acid residue.

  The FEBS journal 20110701

• A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus.

  Diabetes care 20110701

• Highly selective ligand binding by Methylophilus methylotrophus cytochrome c''.

  Biochemistry 20110628

• Unique heme-iron coordination by the hemoglobin receptor IsdB of Staphylococcus aureus.

  Biochemistry 20110621

• Multifrequency electron paramagnetic resonance characterization of PpoA, a CYP450 fusion protein that catalyzes fatty acid dioxygenation.

  Journal of the American Chemical Society 20110615

• Proton-coupled electron transfer reactions at a heme-propionate in an iron-protoporphyrin-IX model compound.

  Journal of the American Chemical Society 20110608

• Sideroblastic anemia: molecular analysis of the ALAS2 gene in a series of 29 probands and functional studies of 10 missense mutations.

  Human mutation 20110601

• Biodiversity in sulfur metabolism in hemiascomycetous yeasts.

  FEMS yeast research 20110601

• Reduced catalytic activity of human CYP2C9 natural alleles for gliclazide: molecular dynamics simulation and docking studies.

  Biochimie 20110601

• Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110601

• Mg-protoporphyrin, haem and sugar signals double cellular total RNA against herbicide and high-light-derived oxidative stress.

  Plant, cell & environment 20110601

• Substituted imidazole of 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates cytochrome P450 2D6 by protein adduction.

  Drug metabolism and disposition: the biological fate of chemicals 20110601

• Autophagy involvement in responses to abscisic acid by plant cells.

  Autophagy 20110601

• The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae.

  Genetics 20110601

• Heme binding to the second, lower-affinity site of the global iron regulator Irr from Rhizobium leguminosarum promotes oligomerization.

  The FEBS journal 20110601

• Probing the local electronic and geometric properties of the heme iron center in a H-NOX domain.

  Journal of inorganic biochemistry 20110601

• Leukotriene B4 mediates neutrophil migration induced by heme.

  Journal of immunology (Baltimore, Md. : 1950) 20110601

• In silico prediction and characterization of 3D structure and binding properties of catalase from the commercially important crab, Scylla serrata.

  Interdisciplinary sciences, computational life sciences 20110601

• Sortase independent and dependent systems for acquisition of haem and haemoglobin in Listeria monocytogenes.

  Molecular microbiology 20110601

• Small colony variants of Staphylococcus aureus reveal distinct protein profiles.

  Proteomics 20110601

• Bioactive dietary polyphenols inhibit heme iron absorption in a dose-dependent manner in human intestinal Caco-2 cells.

  Journal of food science 20110601

• A small fluorophore reporter of protein conformation and redox state.

  Chemical communications (Cambridge, England) 20110528

• Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer.

  The Journal of biological chemistry 20110527

• Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation.

  Biochemistry 20110524

• Probing domain interactions in soluble guanylate cyclase.

  Biochemistry 20110524

• Zinc inhibition of bacterial cytochrome bc(1) reveals the role of cytochrome b E295 in proton release at the Q(o) site.

  Biochemistry 20110524

• Heme synthesis by plastid ferrochelatase I regulates nuclear gene expression in plants.

  Current biology : CB 20110524

• Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria.

  Blood 20110519

• Characterization of a high-spin non-heme Fe(III)-OOH intermediate and its quantitative conversion to an Fe(IV)═O complex.

  Journal of the American Chemical Society 20110518

• Role of the distal hydrogen-bonding network in regulating oxygen affinity in the truncated hemoglobin III from Campylobacter jejuni.

  Biochemistry 20110517

• Naked five-coordinate Fe(III)(NO) porphyrin complexes: vibrational and reactivity features.

  Inorganic chemistry 20110516

• Cobalt cystathionine β-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif.

  Inorganic chemistry 20110516

• Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.

  Bioorganic & medicinal chemistry letters 20110515

• DiGeorge critical region 8 (DGCR8) is a double-cysteine-ligated heme protein.

  The Journal of biological chemistry 20110513

• Oxygen binding and redox properties of the heme in soluble guanylate cyclase: implications for the mechanism of ligand discrimination.

  The Journal of biological chemistry 20110506

• Molecular modeling and dynamics simulation of a histidine-tagged cytochrome b₅.

  Journal of molecular modeling 20110501

• Dietary heme adversely affects experimental colitis in rats, despite heat-shock protein induction.

  Nutrition (Burbank, Los Angeles County, Calif.) 20110501

• The induction of macrophage hemeoxygenase-1 is protective during acute kidney injury in aging mice.

  Kidney international 20110501

• Early failure of N-methyl-D-aspartate receptors and deficient spine formation induced by reduction of regulatory heme in neurons.

  Molecular pharmacology 20110501

• An alternative view of the proposed alternative activities of hemopexin.

  Protein science : a publication of the Protein Society 20110501

• Characterization of heme-binding properties of Paracoccus denitrificans Surf1 proteins.

  The FEBS journal 20110501

• Electronic ground states and vibrational frequency shifts of diatomic ligands in heme adducts.

  Journal of computational chemistry 20110501

• Occurrence and formation of endogenous histidine hexa-coordination in cold-adapted hemoglobins.

  IUBMB life 20110501

• Involvement of the distal Arg residue in Cl⁻ binding of midge larval haemoglobin.

  Acta crystallographica. Section D, Biological crystallography 20110501

• Photosynthetic growth despite a broken Q-cycle.

  Nature communications 20110501

• Haem arginate as effective maintenance therapy for hereditary coproporphyria.

  The Australasian journal of dermatology 20110501

• Crystal structure and biochemical features of EfeB/YcdB from Escherichia coli O157: ASP235 plays divergent roles in different enzyme-catalyzed processes.

  The Journal of biological chemistry 20110429

• Functional and structural roles of residues in the third extramembrane segment of adrenal cytochrome b561.

  Biochemistry 20110419

• Cyclic di-GMP activation of polynucleotide phosphorylase signal-dependent RNA processing.

  Journal of molecular biology 20110415

• Regioselectivity of enzymatic and photochemical single electron transfer promoted carbon-carbon bond fragmentation reactions of tetrameric lignin model compounds.

  The Journal of organic chemistry 20110415

• Metal ion effect on the switch of mechanism from direct oxygen transfer to metal ion-coupled electron transfer in the sulfoxidation of thioanisoles by a non-heme iron(IV)-oxo complex.

  Journal of the American Chemical Society 20110413

• Crystal structures of CO and NO adducts of MauG in complex with pre-methylamine dehydrogenase: implications for the mechanism of dioxygen activation.

  Biochemistry 20110412

• A heme-peptide metalloenzyme mimetic with natural peroxidase-like activity.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110411

• SDS-facilitated in vitro formation of a transmembrane B-type cytochrome is mediated by changes in local pH.

  Journal of molecular biology 20110408

• Hypoxia up-regulates expression of hemoglobin in alveolar epithelial cells.

  American journal of respiratory cell and molecular biology 20110401

• Toxicity biomarkers in autism spectrum disorder: a blinded study of urinary porphyrins.

  Pediatrics international : official journal of the Japan Pediatric Society 20110401

• The heme oxygenase system and oral diseases.

  Oral diseases 20110401

• Ascorbate peroxidase activity of cytochrome c.

  Free radical research 20110401

• Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice.

  Journal of neurosurgery 20110401

• Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants.

  Drug metabolism and disposition: the biological fate of chemicals 20110401

• Biochemical characterization of purified OmcS, a c-type cytochrome required for insoluble Fe(III) reduction in Geobacter sulfurreducens.

  Biochimica et biophysica acta 20110401

• Chemical reactivity of Synechococcus sp. PCC 7002 and Synechocystis sp. PCC 6803 hemoglobins: covalent heme attachment and bishistidine coordination.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110401

• Crystal structure of the carbon monoxide complex of human cytoglobin.

  Proteins 20110401

• Structural and kinetic studies of imidazole binding to two members of the cytochrome c (6) family reveal an important role for a conserved heme pocket residue.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110401

• Reduction potential of yeast cytochrome c peroxidase and three distal histidine mutants: dependence on pH.

  Journal of inorganic biochemistry 20110401

• Low molecular mass thiols, disulfides and protein mixed disulfides in rat tissues: influence of sample manipulation, oxidative stress and ageing.

  Mechanisms of ageing and development 20110401

• Ribose sugars generate internal glycation cross-links in horse heart myoglobin.

  Biochemical and biophysical research communications 20110401

• Tin chloride enhances parvalbumin-positive interneuron survival by modulating heme metabolism in a model of cerebral ischemia.

  Neuroscience letters 20110329

• Modulation of heme orientation and binding by a single residue in catalase HPII of Escherichia coli.

  Biochemistry 20110329

• Kinetics of carbon monoxide migration and binding in solvated neuroglobin as revealed by molecular dynamics simulations and quantum mechanical calculations.

  The journal of physical chemistry. B 20110317

• Artesunate mitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase.

  Nitric oxide : biology and chemistry 20110315

• Lipid binding to cytoglobin leads to a change in haem co-ordination: a role for cytoglobin in lipid signalling of oxidative stress.

  The Biochemical journal 20110315

• Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone.

  Biochemistry 20110315

• Intermonomer electron transfer between the low-potential b hemes of cytochrome bc₁.

  Biochemistry 20110315

• Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway.

  The Journal of biological chemistry 20110304

• Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer.

  Archives of biochemistry and biophysics 20110301

• Reciprocal regulation of Ca²+-activated outward K+ channels of Pyrus pyrifolia pollen by heme and carbon monoxide.

  The New phytologist 20110301

• Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy.

  International immunopharmacology 20110301

• Molecular basis for the inability of an oxygen atom donor ligand to replace the natural sulfur donor heme axial ligand in cytochrome P450 catalysis. Spectroscopic characterization of the Cys436Ser CYP2B4 mutant.

  Archives of biochemistry and biophysics 20110301

• Spectroscopic features of cytochrome P450 reaction intermediates.

  Archives of biochemistry and biophysics 20110301

• Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme.

  American journal of physiology. Heart and circulatory physiology 20110301

• Red meat, dietary nitrosamines, and heme iron and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110301

• Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin.

  The American journal of pathology 20110301

• Blood meal-derived heme decreases ROS levels in the midgut of Aedes aegypti and allows proliferation of intestinal microbiota.

  PLoS pathogens 20110301

• Protonation of histidine 55 affects the oxygen access to heme in the alpha chain of the hemoglobin from the Antarctic fish Trematomus bernacchii.

  IUBMB life 20110301

• Theoretical insights into heme-catalyzed oxidation of cyclohexane to adipic acid.

  Inorganic chemistry 20110221

• Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.

  ACS chemical biology 20110218

• Guanine-rich RNAs and DNAs that bind heme robustly catalyze oxygen transfer reactions.

  Journal of the American Chemical Society 20110216

• Enantiospecificity of chloroperoxidase-catalyzed epoxidation: biased molecular dynamics study of a cis-β-methylstyrene/chloroperoxidase-compound I complex.

  Biophysical journal 20110216

• Structural design of the active site for covalent attachment of the heme to the protein matrix: studies on a thermostable cytochrome P450.

  Biochemistry 20110215

• Unusual heme binding in the bacterial iron response regulator protein: spectral characterization of heme binding to the heme regulatory motif.

  Biochemistry 20110215

• Nitric oxide dioxygenation reaction in DevS and the initial response to nitric oxide in Mycobacterium tuberculosis.

  Biochemistry 20110215

• Normal and abnormal heme biosynthesis. Part 7. Synthesis and metabolism of coproporphyrinogen-III analogues with acetate or butyrate side chains on rings C and D. Development of a modified model for the active site of coproporphyrinogen oxidase.

  Bioorganic & medicinal chemistry 20110215

• Thiol-disulfide redox dependence of heme binding and heme ligand switching in nuclear hormone receptor rev-erb{beta}.

  The Journal of biological chemistry 20110211

• The proapoptotic G41S mutation to human cytochrome c alters the heme electronic structure and increases the electron self-exchange rate.

  Journal of the American Chemical Society 20110209

• Cellular levels of heme affect the activity of dimeric glutamyl-tRNA reductase.

  Biochemical and biophysical research communications 20110204

• Axial ligation of the high-potential heme center in an Arabidopsis cytochrome b561.

  FEBS letters 20110204

• Glutathionyl-biliverdin IXα, a new heme catabolite in a marine annelid: Sex and cell specific accumulation.

  Biochimie 20110201

• Heme-binding characteristics of the isolated PAS-B domain of mouse Per2, a transcriptional regulatory factor associated with circadian rhythms.

  Biochimica et biophysica acta 20110201

• Conformational and thermal stability of mature dimeric human myeloperoxidase and a recombinant monomeric form from CHO cells.

  Biochimica et biophysica acta 20110201

• Egr-1 regulates the transcriptional repression of mouse δ-aminolevulinic acid synthase 1 by heme.

  Gene 20110201

• Intravenous immunoglobulins exposed to heme (heme IVIG) are more efficient than IVIG in attenuating autoimmune diabetes.

  Clinical immunology (Orlando, Fla.) 20110201

• Calcium carbonate suppresses haem toxicity markers without calcium phosphate side effects on colon carcinogenesis.

  The British journal of nutrition 20110201

• The mitochondrial protein frataxin is essential for heme biosynthesis in plants.

  The FEBS journal 20110201

• Reduction of oxaporphyrin ring of CO-bound α-verdoheme complexed with heme oxygenase-1 by NADPH-cytochrome P450 reductase.

  Journal of inorganic biochemistry 20110201

• Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme-albumin.

  The FEBS journal 20110201

• The axial ligand effect on aliphatic and aromatic hydroxylation by non-heme iron(IV)-oxo biomimetic complexes.

  Chemistry, an Asian journal 20110201

• Modeling the cis-oxo-labile binding site motif of non-heme iron oxygenases: water exchange and oxidation reactivity of a non-heme iron(IV)-oxo compound bearing a tripodal tetradentate ligand.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110201

• The structure of a haemopexin-fold protein from cow pea (Vigna unguiculata) suggests functional diversity of haemopexins in plants.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20110201

• CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.

  Current drug metabolism 20110201

• Actovegin®: a biological drug for more than 5 decades.

  Wiener medizinische Wochenschrift (1946) 20110201

• Topological study of the late steps of the artemisinin decomposition process: modeling the outcome of the experimentally obtained products.

  The journal of physical chemistry. B 20110120

• Catalytic mechanism of a heme and tyrosyl radical-containing fatty acid α-(di)oxygenase.

  Journal of the American Chemical Society 20110119

• The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials.

  The Journal of biological chemistry 20110114

• Nature of the ferryl heme in compounds I and II.

  The Journal of biological chemistry 20110114

• Structural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444.

  Chembiochem : a European journal of chemical biology 20110103

• The 'Raman spectroscopic signature of life' is closely related to haem function in budding yeasts.

  Journal of biophotonics 20110101

• Rapid, convenient method for screening imidazole-containing compounds for heme oxygenase inhibition.

  Journal of pharmacological and toxicological methods 20110101

• Expression, purification and characterization of two Clostridium acetobutylicum flavodoxins: potential electron transfer partners for CYP152A2.

  Biochimica et biophysica acta 20110101

• The explosive-degrading cytochrome P450 XplA: biochemistry, structural features and prospects for bioremediation.

  Biochimica et biophysica acta 20110101

• Stabilization and spectroscopic characterization of the dioxygen complex of wild-type cytochrome P4502B4 (CYP2B4) and its distal side E301Q, T302A and proximal side F429H mutants at subzero temperatures.

  Biochimica et biophysica acta 20110101

• Heme destruction, the main molecular event during the peroxide-mediated inactivation of chloroperoxidase from Caldariomyces fumago.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110101

• Bacterial sulfite-oxidizing enzymes.

  Biochimica et biophysica acta 20110101

• Understanding uncoupling in the multiredox centre P450 3A4-BMR model system.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110101

• Short circuiting a sulfite oxidising enzyme with direct electrochemistry: active site substitutions and their effect on catalysis and electron transfer.

  Biochimica et biophysica acta 20110101

• Isoniazid and rifampicin inhibit allosterically heme binding to albumin and peroxynitrite isomerization by heme-albumin.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110101

• Immunoregulatory properties of heme oxygenase-1.

  Methods in molecular biology (Clifton, N.J.) 20110101

• Inhibition of cytochrome P450 1A2-mediated metabolism and production of reactive oxygen species by heme oxygenase-1 in rat liver microsomes.

  Drug metabolism letters 20110101

• Mesohaem substitution reveals how haem electronic properties can influence the kinetic and catalytic parameters of neuronal NO synthase.

  The Biochemical journal 20110101

• Quantitating carbon monoxide production from heme by vascular plant preparations in vitro.

  Plant physiology and biochemistry : PPB 20110101

• Distal mutation modulates the heme sliding in mouse neuroglobin investigated by molecular dynamics simulation.

  Proteins 20110101

• Mammal cells double their total RNAs against diabetes, ischemia reperfusion and malaria-induced oxidative stress.

  Molecular medicine (Cambridge, Mass.) 20110101

• Production of recombinant multiheme cytochromes c in Wolinella succinogenes.

  Methods in enzymology 20110101

• A structural and functional analysis of type III periplasmic and substrate binding proteins: their role in bacterial siderophore and heme transport.

  Biological chemistry 20110101

• Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions.

  The American journal of pathology 20110101

• Structural analysis of heme proteins: implications for design and prediction.

  BMC structural biology 20110101

• HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by Porphyromonas gingivalis.

  PloS one 20110101

• Global gene expression profiling of endothelium exposed to heme reveals an organ-specific induction of cytoprotective enzymes in sickle cell disease.

  PloS one 20110101

• Structure and function of formate-dependent cytochrome c nitrite reductase, NrfA.

  Methods in enzymology 20110101

• Biochemical properties of indoleamine 2,3-dioxygenase: from structure to optimized design of inhibitors.

  Current medicinal chemistry 20110101

• A bioinformatics classifier and database for heme-copper oxygen reductases.

  PloS one 20110101

• Genomic characterization of Haemophilus parasuis SH0165, a highly virulent strain of serovar 5 prevalent in China.

  PloS one 20110101

• HemeBIND: a novel method for heme binding residue prediction by combining structural and sequence information.

  BMC bioinformatics 20110101

• Roles of porphyrin and iron metabolisms in the δ-aminolevulinic acid (ALA)-induced accumulation of protoporphyrin and photodamage of tumor cells.

  Photochemistry and photobiology 20110101

• Electron transfer function versus oxygen delivery: a comparative study for several hexacoordinated globins across the animal kingdom.

  PloS one 20110101

• Fish oil feeding up-regulates the expression of 5-aminolevulinate synthase 2 mRNA in rat brain.

  Bioscience, biotechnology, and biochemistry 20110101

• Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells.

  PloS one 20110101

• Cytochrome c-554 from Methylosinus trichosporium OB3b; a protein that belongs to the cytochrome c2 family and exhibits a HALS-Type EPR signal.

  PloS one 20110101

• Hb Lake Tapawingo [α46(CE4)Phe→Ser; HBA2:c.140T>C]: a new unstable α chain hemoglobin variant associated with low systemic arterial saturation.

  Hemoglobin 20110101

• High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment.

  PloS one 20110101

• Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts.

  PloS one 20110101

• Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells.

  PloS one 20110101

• Methods for analysis of photosynthetic pigments and steady-state levels of intermediates of tetrapyrrole biosynthesis.

  Methods in molecular biology (Clifton, N.J.) 20110101

• [Inhibition of no-dependent soluble human platelet guanylate cyclase by isatin].

  Biomeditsinskaia khimiia 20110101

• [miR-122, a microRNA gatekeeper of iron homeostasis].

  Medecine sciences : M/S 20110101

• [Pharmacologic neuroprotection of the brain in carotid artery surgeries].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

• A membrane-bound vertebrate globin.

  PloS one 20110101

• Computational prediction of heme-binding residues by exploiting residue interaction network.

  PloS one 20110101

• Heme-induced ROS in Trypanosoma cruzi activates CaMKII-like that triggers epimastigote proliferation. One helpful effect of ROS.

  PloS one 20110101

• The Escherichia coli protein YfeX functions as a porphyrinogen oxidase, not a heme dechelatase.

  mBio 20110101

• Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity.

  PloS one 20110101

• Up-regulation of A1M/α1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage.

  PloS one 20110101

• Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory diseases.

  PloS one 20110101

• Congenital sideroblastic anemias: iron and heme lost in mitochondrial translation.

  Hematology. American Society of Hematology. Education Program 20110101

• A real-time PCR antibiogram for drug-resistant sepsis.

  PloS one 20110101

• Characterization of a wheat heme oxygenase-1 gene and its responses to different abiotic stresses.

  International journal of molecular sciences 20110101

• [Comparative aspects of using neuroprotectors in the management of patients with ischemic stroke].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

• [Pharmacological neuroprotection against brain damage in ischemiai/reperfusion experiment].

  Eksperimental'naia i klinicheskaia farmakologiia 20110101

• [Neuroprotector therapy of patients with decompensated diabetes mellitus type 1].

  Eksperimental'naia i klinicheskaia farmakologiia 20110101

• Structural characterization of spectroscopic substates in carbonmonoxy neuroglobin.

  Faraday discussions 20110101

• Roles of SIRT1 in the acute and restorative phases following induction of inflammation.

  The Journal of biological chemistry 20101231

• Heme oxygenase system in hepatic ischemia-reperfusion injury.

  World journal of gastroenterology 20101228

• Perturbed heme binding is responsible for the blistering phenotype associated with mutations in the Caenorhabditis elegans dual oxidase 1 (DUOX1) peroxidase domain.

  The Journal of biological chemistry 20101224

• Characterization of a hemophore-like protein from Porphyromonas gingivalis.

  The Journal of biological chemistry 20101217

• A neutral zwitterionic molecular solid.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20101217

• Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential.

  Biochemical pharmacology 20101215

• Mercury modulates the CYP1A1 at transcriptional and posttranslational levels in human hepatoma HepG2 cells.

  Toxicology letters 20101215

• Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity.

  The Journal of biological chemistry 20101210

• Redox and electrocatalytic properties of mimochrome VI, a synthetic heme peptide adsorbed on gold.

  Langmuir : the ACS journal of surfaces and colloids 20101207

• Heme controls the regulation of protein tyrosine kinases Jak2 and Src.

  Biochemical and biophysical research communications 20101203

• Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression.

  The pharmacogenomics journal 20101201

• Characterization of two cytochrome b6 proteins from the cyanobacterium Gloeobacter violaceus PCC 7421.

  Journal of bioenergetics and biomembranes 20101201

• Essential histidine pairs indicate conserved haem binding in epsilonproteobacterial cytochrome c haem lyases.

  Microbiology (Reading, England) 20101201

• Haem arginate infusion stimulates haem oxygenase-1 expression in healthy subjects.

  British journal of pharmacology 20101201

• Role of domains within the autotransporter Hbp/Tsh.

  Acta crystallographica. Section D, Biological crystallography 20101201

• Changes in optical properties of rat cerebral cortical slices during oxygen glucose deprivation.

  Applied optics 20101201

• Variability of microsomal oxidation and porphyrin metabolism in rats.

  Bulletin of experimental biology and medicine 20101201

• Pregnancy loss and maternal methemoglobin levels: an indirect explanation of the association of environmental toxics and their adverse effects on the mother and the fetus.

  International journal of environmental research and public health 20101201

• [Recent progress in iron metabolism and iron-related anemia].

  Rinsho byori. The Japanese journal of clinical pathology 20101201

• Enzymatic ring opening of an iron corrole by plant-type heme oxygenases: unexpected substrate and protein selectivities.

  Biochemistry 20101130

• A specific interaction of L-tryptophan with CO of CO-bound indoleamine 2,3-dioxygenase identified by resonance Raman spectroscopy.

  Biochemistry 20101130

• Two stacked heme molecules in the binding pocket of the periplasmic heme-binding protein HmuT from Yersinia pestis.

  Journal of molecular biology 20101126

• Heme as trigger and target for trioxane-containing antimalarial drugs.

  Accounts of chemical research 20101116

• Functional importance of tyrosine 294 and the catalytic selectivity for the bis-Fe(IV) state of MauG revealed by replacement of this axial heme ligand with histidine .

  Biochemistry 20101116

• Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake.

  The Biochemical journal 20101115

• Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcus pyogenes.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20101101

• Nitroxide spin labels as EPR reporters of the relaxation and magnetic properties of the heme-copper site in cytochrome bo3, E. coli.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20101101

• Colour, lipid and protein stability of Rhea americana meat during air- and vacuum-packaged storage: influence of muscle on oxidative processes.

  Meat science 20101101

• Low temperature photo-oxidation of chloroperoxidase Compound II.

  Journal of inorganic biochemistry 20101101

• Human heme oxygenase-1 efficiently catabolizes heme in the absence of biliverdin reductase.

  Drug metabolism and disposition: the biological fate of chemicals 20101101

• Modification of the heme active site to increase the peroxidase activity of thermophilic cytochrome P450: a rational approach.

  Journal of inorganic biochemistry 20101101

• Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins.

  Journal of molecular graphics & modelling 20101101

• 4-Aminoquinoline derived antimalarials: synthesis, antiplasmodial activity and heme polymerization inhibition studies.

  European journal of medicinal chemistry 20101101

• Shr of group A streptococcus is a new type of composite NEAT protein involved in sequestering haem from methaemoglobin.

  Molecular microbiology 20101101

• The Fowler syndrome-associated protein FLVCR2 is an importer of heme.

  Molecular and cellular biology 20101101

• Cytochromes: Reactivity of the 'dark side' of the heme.

  Biophysical chemistry 20101101

• Effects of large-scale amino acid substitution in the polypeptide tether connecting the heme and molybdenum domains on catalysis in human sulfite oxidase.

  Metallomics : integrated biometal science 20101101

• Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir.

  Proceedings of the National Academy of Sciences of the United States of America 20101026

• Pro-healing potential of hemin: an inducer of heme oxygenase-1.

  European journal of pharmacology 20101025

• ABCG2 transports and transfers heme to albumin through its large extracellular loop.

  The Journal of biological chemistry 20101022

• Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation.

  The Journal of biological chemistry 20101022

• Electron transfer in a human inducible nitric oxide synthase oxygenase/FMN construct co-expressed with the N-terminal globular domain of calmodulin.

  FEBS letters 20101022

• Unprecedented peroxidase-like activity of Rhodnius prolixus nitrophorin 2: identification of the [FeIV=O Por•]+ and [FeIV=O Por](Tyr38•) intermediates and their role(s) in substrate oxidation.

  Biochemistry 20101019

• Improved cytochrome P450 3A4 molecular models accurately predict the Phe215 requirement for raloxifene dehydrogenation selectivity.

  Biochemistry 20101019

• GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.

  ACS chemical biology 20101015

• Intramolecular heme ligation of the cytochrome P450 2C9 R108H mutant demonstrates pronounced conformational flexibility of the B-C loop region: implications for substrate binding.

  Biochemistry 20101012

• A retrospective analysis of outcome of pregnancy in patients with acute porphyria.

  Journal of inherited metabolic disease 20101001

• The heme pocket of the globin domain of the globin-coupled sensor of Geobacter sulfurreducens--an EPR study.

  Journal of inorganic biochemistry 20101001

• Heme oxygenase-1 deficiency leads to alteration of soluble guanylate cyclase redox regulation.

  The Journal of pharmacology and experimental therapeutics 20101001

• A heme fusion tag for protein affinity purification and quantification.

  Protein science : a publication of the Protein Society 20101001

• c-type cytochrome assembly in Saccharomyces cerevisiae: a key residue for apocytochrome c1/lyase interaction.

  Genetics 20101001

• Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins.

  Periodontology 2000 20101001

• Structural determinants for the formation of sulfhemeprotein complexes.

  Biochemical and biophysical research communications 20101001

• A prospective, randomized, multi-center trial to investigate Actovegin in prevention and treatment of acute oral mucositis caused by chemoradiotherapy for nasopharyngeal carcinoma.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20101001

• The porphyrias: pathophysiology.

  Internal and emergency medicine 20101001

• Porphyrias at a glance: diagnosis and treatment.

  Internal and emergency medicine 20101001

• Porphyria cutanea tarda--when skin meets liver.

  Best practice & research. Clinical gastroenterology 20101001

• Drug binding to Sudlow's site I impairs allosterically human serum heme-albumin-catalyzed peroxynitrite detoxification.

  IUBMB life 20101001

• DsrJ, an essential part of the DsrMKJOP transmembrane complex in the purple sulfur bacterium Allochromatium vinosum, is an unusual triheme cytochrome c.

  Biochemistry 20100928

• Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.

  The Journal of biological chemistry 20100924

• Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase.

  Biochemical and biophysical research communications 20100924

• Enzymatic ring-opening mechanism of verdoheme by the heme oxygenase: a combined X-ray crystallography and QM/MM study.

  Journal of the American Chemical Society 20100922

• Kinetic analysis of 14-3-3-inhibited Arabidopsis thaliana nitrate reductase.

  Biochemistry 20100921

• Multiconformation continuum electrostatics analysis of the effects of a buried Asp introduced near heme a in Rhodobacter sphaeroides cytochrome c oxidase.

  Biochemistry 20100921

• Long-range electron transfer in recombinant peroxidases anisotropically orientated on gold electrodes.

  Physical chemistry chemical physics : PCCP 20100914

• Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin.

  The Journal of biological chemistry 20100910

• Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds.

  Journal of medicinal chemistry 20100909

• Variation and analysis of second-sphere interactions and axial histidinate character in c-type cytochromes.

  Inorganic chemistry 20100906

• Co-expression of ferrochelatase allows for complete heme incorporation into recombinant proteins produced in E. coli.

  Protein expression and purification 20100901

• The quinohaemoprotein alcohol dehydrogenase from Gluconacetobacter xylinus: molecular and catalytic properties.

  Archives of microbiology 20100901

• Heme-dependent and independent soluble guanylate cyclase activators and vasodilation.

  Journal of cardiovascular pharmacology 20100901

• Pulsed EPR determination of the distance between heme iron and FMN centers in a human inducible nitric oxide synthase.

  Journal of the American Chemical Society 20100901

• Role of dipstick in detection of haeme pigment due to rhabdomyolysis in victims of Bam earthquake.

  Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20100901

• Elucidating the catalytic mechanism of sulfite oxidizing enzymes using structural, spectroscopic, and kinetic analyses.

  Biochemistry 20100831

• Fluoride-dependent conversion of organic compounds mediated by manganese peroxidases in the absence of Mn(2+) ions.

  Biochemistry 20100831

• Absorption in the Q-band region by isolated ferric heme+ and heme+(histidine) in vacuo.

  The Journal of chemical physics 20100828

• Giardia lamblia encodes a functional flavohemoglobin.

  Biochemical and biophysical research communications 20100827

• Viscosity-dependent dynamics of CO rebinding to microperoxidase-8 in glycerol/water solution.

  The journal of physical chemistry. B 20100826

• Engineering of the heme pocket of an H-NOX domain for direct cyanide detection and quantification.

  Journal of the American Chemical Society 20100825

• Discovery and Characterization of HemQ: an essential heme biosynthetic pathway component.

  The Journal of biological chemistry 20100820

• Characterization of a six-coordinate ferrous high-spin heme with both intramolecular axial carboxylic acid and pyridine.

  Journal of the American Chemical Society 20100811

• Regulation of beta-lactamase activity by remote binding of heme: functional coupling of unrelated proteins through domain insertion.

  Biochemistry 20100810

• Heme induces DNA damage and hyperproliferation of colonic epithelial cells via hydrogen peroxide produced by heme oxygenase: a possible mechanism of heme-induced colon cancer.

  Molecular nutrition & food research 20100801

• Theoretical investigation of the ring opening process of verdoheme to biliverdin in the presence of dioxygen.

  Journal of molecular modeling 20100801

• Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter.

  Haematologica 20100801

• The IL-12p70/IL-10 interplay is differentially regulated by free heme and hemozoin in murine bone-marrow-derived macrophages.

  International journal for parasitology 20100801

• Redox properties of heme peroxidases.

  Archives of biochemistry and biophysics 20100801

• Reaction of N-hydroxyguanidine with the ferrous-oxy state of a heme peroxidase cavity mutant: a model for the reactions of nitric oxide synthase.

  Archives of biochemistry and biophysics 20100801

• Evolution of structure and function of Class I peroxidases.

  Archives of biochemistry and biophysics 20100801

• Structure and spin density of ferric low-spin heme complexes determined with high-resolution ESEEM experiments at 35 GHz.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100801

• Spectroscopic properties of rubber oxygenase RoxA from Xanthomonas sp., a new type of dihaem dioxygenase.

  Microbiology (Reading, England) 20100801

• Oxidative stability of gelatin coated pork at refrigerated storage.

  Meat science 20100801

• A computational analysis of electromerism in hemoprotein Fe(I) models.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100801

• A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells.

  Genome research 20100801

• Ferritin does not donate its iron for haem synthesis in macrophages.

  The Biochemical journal 20100801

• Direct assay of delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry.

  Analytical chemistry 20100801

• Molecular dynamics simulations of cytochrome c unfolding in AOT reverse micelles: The first steps.

  The European physical journal. E, Soft matter 20100801

• Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes.

  The Journal of biological chemistry 20100730

• Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis.

  Blood 20100729

• Functional switching of Amphitrite ornata dehaloperoxidase from O2-binding globin to peroxidase enzyme facilitated by halophenol substrate and H2O2.

  Biochemistry 20100727

• c-Type cytochrome biogenesis can occur via a natural Ccm system lacking CcmH, CcmG, and the heme-binding histidine of CcmE.

  The Journal of biological chemistry 20100723

• Electronic structure of heme-nitrosyls and its significance for nitric oxide reactivity, sensing, transport, and toxicity in biological systems.

  Inorganic chemistry 20100719

• Plastid-associated porphobilinogen synthase from Toxoplasma gondii: kinetic and structural properties validate therapeutic potential.

  The Journal of biological chemistry 20100716

• Binding of imidazole to the heme of cytochrome c1 and inhibition of the bc1 complex from Rhodobacter sphaeroides: I. Equilibrium and modeling studies.

  The Journal of biological chemistry 20100716

• Binding of imidazole to the heme of cytochrome c1 and inhibition of the bc1 complex from Rhodobacter sphaeroides: II. Kinetics and mechanism of binding.

  The Journal of biological chemistry 20100716

• Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.

  The Journal of biological chemistry 20100716

• Redox status affects the catalytic activity of glutamyl-tRNA synthetase.

  Biochemical and biophysical research communications 20100716

• Structural evidence for the functional importance of the heme domain mobility in flavocytochrome b2.

  Journal of molecular biology 20100716

• The structure of cbb3 cytochrome oxidase provides insights into proton pumping.

  Science (New York, N.Y.) 20100716

• Heme impairs prostaglandin E2 and TGF-beta production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria.

  Journal of immunology (Baltimore, Md. : 1950) 20100715

• Formation of cysteine sulfenic acid by oxygen atom transfer from nitrite.

  Journal of the American Chemical Society 20100714

• Structure and properties of a bis-histidyl ligated globin from Caenorhabditis elegans.

  Biochemistry 20100713

• Molecular insight into intrinsic heme distortion in ligand binding in hemoprotein.

  Biochemistry 20100713

• Long-range electron transfer reactions between hemes of MauG and different forms of tryptophan tryptophylquinone of methylamine dehydrogenase.

  Biochemistry 20100713

• The ternary complex of PrnB (the second enzyme in the pyrrolnitrin biosynthesis pathway), tryptophan, and cyanide yields new mechanistic insights into the indolamine dioxygenase superfamily.

  The Journal of biological chemistry 20100702

• Metal ions and electrolytes regulate the dissociation of heme from human hemopexin at physiological pH.

  The Journal of biological chemistry 20100702

• Spectral characterization of the recombinant mouse tumor suppressor 101F6 protein.

  European biophysics journal : EBJ 20100701

• Red cells, hemoglobin, heme, iron, and atherogenesis.

  Arteriosclerosis, thrombosis, and vascular biology 20100701

• Time-dependant protective effects of mangenese(III) tetrakis (1-methyl-4-pyridyl) porphyrin on mitochondrial function following renal ischemia-reperfusion injury.

  Free radical research 20100701

• Heme arginate therapy enhanced adiponectin and atrial natriuretic peptide, but abated endothelin-1 with attenuation of kidney histopathological lesions in mineralocorticoid-induced hypertension.

  The Journal of pharmacology and experimental therapeutics 20100701

• Regulation of adipogenesis by natural and synthetic REV-ERB ligands.

  Endocrinology 20100701

• New and classic families of secreted fungal heme peroxidases.

  Applied microbiology and biotechnology 20100701

• Meat processing and colon carcinogenesis: cooked, nitrite-treated, and oxidized high-heme cured meat promotes mucin-depleted foci in rats.

  Cancer prevention research (Philadelphia, Pa.) 20100701

• Conformational changes near the cytochrome P450 active site upon binding of two different ligands.

  Biochemistry. Biokhimiia 20100701

• Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans.

  PLoS genetics 20100701

• Nitric oxide binds to the proximal heme coordination site of the ferrocytochrome c/cardiolipin complex: formation mechanism and dynamics.

  The Journal of biological chemistry 20100625

• Identification of a thiol/disulfide redox switch in the human BK channel that controls its affinity for heme and CO.

  The Journal of biological chemistry 20100625

• Characterization of the decaheme c-type cytochrome OmcA in solution and on hematite surfaces by small angle x-ray scattering and neutron reflectometry.

  Biophysical journal 20100616

• Heme synthesis increases artemisinin-induced radical formation and cytotoxicity that can be suppressed by superoxide scavengers.

  Chemico-biological interactions 20100607

• Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding.

  The Journal of biological chemistry 20100604

• NirJ, a radical SAM family member of the d1 heme biogenesis cluster.

  FEBS letters 20100603

• Oxygen-dependence of metabolic rate in the muscles of craniates.

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20100601

• Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetylene.

  The Journal of pharmacology and experimental therapeutics 20100601

• Nitric oxide blocks cellular heme insertion into a broad range of heme proteins.

  Free radical biology & medicine 20100601

• H-NOX domains display different tunnel systems for ligand migration.

  Journal of molecular graphics & modelling 20100601

• Fe-heme structure in Cu, Zn superoxide dismutase from Haemophilus ducreyi by X-ray absorption spectroscopy.

  Archives of biochemistry and biophysics 20100601

• Ultrahigh (0.93A) resolution structure of manganese peroxidase from Phanerochaete chrysosporium: implications for the catalytic mechanism.

  Journal of inorganic biochemistry 20100601

• Cytochrome c biogenesis: the Ccm system.

  Trends in microbiology 20100601

• QM/MM methods: looking inside heme proteins biochemistry.

  Biophysical chemistry 20100601

• Structure and function of enzymes in heme biosynthesis.

  Protein science : a publication of the Protein Society 20100601

• Characterization of conformational changes and noncovalent complexes of myoglobin by electrospray ionization mass spectrometry, circular dichroism and fluorescence spectroscopy.

  Journal of mass spectrometry : JMS 20100601

• In vivo production of catalase containing haem analogues.

  The FEBS journal 20100601

• Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis.

  The Journal of biological chemistry 20100528

• Direct electrochemistry of cytochrome c at modified Si(100) electrodes.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20100525

• Normal and abnormal heme biosynthesis. 6. Synthesis and metabolism of a series of monovinylporphyrinogens related to harderoporphyrinogen. Further insights into the oxidative decarboxylation of porphyrinogen substrates by coproporphyrinogen oxidase.

  The Journal of organic chemistry 20100521

• Five- and six-coordinate adducts of nitrosamines with ferric porphyrins: structural models for the Type II interactions of nitrosamines with ferric cytochrome P450.

  Inorganic chemistry 20100517

• On the enzymatic activity of catalase: an iron L-edge X-ray absorption study of the active centre.

  Physical chemistry chemical physics : PCCP 20100514

• Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.

  Biochemistry 20100511

• Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts.

  The Journal of clinical investigation 20100503

• LICRED: a versatile drop-in vector for rapid generation of redox-self-sufficient cytochrome P450s.

  Chembiochem : a European journal of chemical biology 20100503

• Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats.

  Nutrition (Burbank, Los Angeles County, Calif.) 20100501

• A robust and extracellular heme-containing peroxidase from Thermobifida fusca as prototype of a bacterial peroxidase superfamily.

  Applied microbiology and biotechnology 20100501

• Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.

  Drug metabolism and disposition: the biological fate of chemicals 20100501

• Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule.

  The Journal of pharmacology and experimental therapeutics 20100501

• Binding of anti-Parkinson's disease drugs to human serum albumin is allosterically modulated.

  IUBMB life 20100501

• Alcohol dehydrogenase of acetic acid bacteria: structure, mode of action, and applications in biotechnology.

  Applied microbiology and biotechnology 20100501

• Allostery in a monomeric protein: the case of human serum albumin.

  Biophysical chemistry 20100501

• The effects of type II binding on metabolic stability and binding affinity in cytochrome P450 CYP3A4.

  Archives of biochemistry and biophysics 20100501

• Rapid dark repression of 5-aminolevulinic acid synthesis in green barley leaves.

  Plant & cell physiology 20100501

• Haem oxygenase (HO): an overlooked enzyme of plant metabolism and defence.

  Journal of experimental botany 20100501

• [The anti-athetotic effects of heme-L-lysinate in a rabbit model of atherosclerosis].

  Zhonghua xin xue guan bing za zhi 20100501

• How active-site protonation state influences the reactivity and ligation of the heme in chlorite dismutase.

  Journal of the American Chemical Society 20100428

• P450cam visits an open conformation in the absence of substrate.

  Biochemistry 20100427

• Understanding properties of cofactors in proteins: redox potentials of synthetic cytochromes b.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20100426

• Dioxygen activation for the self-degradation of heme: reaction mechanism and regulation of heme oxygenase.

  Inorganic chemistry 20100419

• Heme-copper-dioxygen complexes: toward understanding ligand-environmental effects on the coordination geometry, electronic structure, and reactivity.

  Inorganic chemistry 20100419

• Crystal structure of the electron carrier domain of the reaction center cytochrome c(z) subunit from green photosynthetic bacterium Chlorobium tepidum.

  Journal of molecular biology 20100416

• Electronic structures of heme a of cytochrome c oxidase in the redox states--charge density migration to the propionate groups of heme a.

  Journal of computational chemistry 20100415

• Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3.

  The Biochemical journal 20100414

• Aberrant attachment of heme to cytochrome by the Ccm system results in a cysteine persulfide linkage.

  Journal of the American Chemical Society 20100414

• Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition.

  Biochemistry 20100413

• A comparison of the higher order harmonic components derived from large-amplitude Fourier transformed ac voltammetry of myoglobin and heme in DDAB films at a pyrolytic graphite electrode.

  Langmuir : the ACS journal of surfaces and colloids 20100406

• Light-induced cytotoxicity after aminolevulinic acid treatment is mediated by heme and not by iron.

  Journal of photochemistry and photobiology. B, Biology 20100402

• Molecular dynamics simulation of a carboxy murine neuroglobin mutated on the proximal side: heme displacement and concomitant rearrangement in loop regions.

  Journal of molecular modeling 20100401

• On the diversity of physicochemical environments experienced by identical ligands in binding pockets of unrelated proteins.

  Proteins 20100401

• In-depth analysis of the distinctive effects of norflurazon implies that tetrapyrrole biosynthesis, organellar gene expression and ABA cooperate in the GUN-type of plastid signalling.

  Physiologia plantarum 20100401

• Lack of hemodynamic effects after extended heme synthesis inhibition by succinylacetone in rats.

  The Journal of pharmacology and experimental therapeutics 20100401

• Characterization of the Haemophilus influenzae tehB gene and its role in virulence.

  Microbiology (Reading, England) 20100401

• Chlorophyll-deficient mutants of Chlamydomonas reinhardtii that accumulate magnesium protoporphyrin IX.

  Plant molecular biology 20100401

• Structural insights into the molecular mechanism of H-NOX activation.

  Protein science : a publication of the Protein Society 20100401

• Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers.

  Free radical research 20100401

• Functional differentiation of two analogous coproporphyrinogen III oxidases for heme and chlorophyll biosynthesis pathways in the cyanobacterium Synechocystis sp. PCC 6803.

  Plant & cell physiology 20100401

• Heme-arginate suppresses phospholipase C and oxidative stress in the mesenteric arterioles of mineralcorticoid-induced hypertensive rats.

  Hypertension research : official journal of the Japanese Society of Hypertension 20100401

• Zinc intake and the risk of hyperglycemia among Chinese adults: the prospective Jiangsu Nutrition Study (JIN).

  The journal of nutrition, health & aging 20100401

• Two coregulated efflux transporters modulate intracellular heme and protoporphyrin IX availability in Streptococcus agalactiae.

  PLoS pathogens 20100401

• Physical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress.

  Journal of the American Chemical Society 20100324

• Formation of an end-on ferric peroxo intermediate upon one-electron reduction of a ferric superoxo heme.

  Journal of the American Chemical Society 20100324

• Electrochemical behavior of biocatalytical composite based on heme-proteins, didodecyldimethylammonium bromide and room-temperature ionic liquid.

  Analytica chimica acta 20100317

• CO binding and ligand discrimination in human myeloperoxidase.

  Biochemistry 20100316

• Role of C-terminal acidic cluster in stabilization of heme spin state of ascorbate peroxidase from Leishmania major.

  Archives of biochemistry and biophysics 20100315

• The evolution, metabolism and functions of the apicoplast.

  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20100312

• Role of arginine guanidinium moiety in nitric-oxide synthase mechanism of oxygen activation.

  The Journal of biological chemistry 20100305

• Mutagenesis studies of human cystathionine beta-synthase: residues important for heme binding and substrate interactions.

  Protein and peptide letters 20100301

• Neutralization of toxic haem by Porphyromonas gingivalis haemoglobin receptor.

  Journal of biochemistry 20100301

• How does a valine residue that modulates heme-NO binding kinetics in inducible NO synthase regulate enzyme catalysis?

  Journal of inorganic biochemistry 20100301

• Iron regulation through the back door: iron-dependent metabolite levels contribute to transcriptional adaptation to iron deprivation in Saccharomyces cerevisiae.

  Eukaryotic cell 20100301

• Unusual proximal heme pocket geometry in the deoxygenated Thermobifida fusca: A combined spectroscopic investigation.

  Biophysical chemistry 20100301

• Mitochondria isolated in nearly isotonic KCl buffer: focus on cardiolipin and organelle morphology.

  Biochimica et biophysica acta 20100301

• Correlation of atomic force microscopy and Raman micro-spectroscopy to study the effects of ex vivo treatment procedures on human red blood cells.

  The Analyst 20100301

• The IsdG-family of haem oxygenases degrades haem to a novel chromophore.

  Molecular microbiology 20100301

• Serological profiling of a Candida albicans protein microarray reveals permanent host-pathogen interplay and stage-specific responses during candidemia.

  PLoS pathogens 20100301

• DFT study of a model system for the dealkylation step catalyzed by AlkB.

  Interdisciplinary sciences, computational life sciences 20100301

• Effect of dietary melanoidins on lipid peroxidation during simulated gastric digestion: their possible role in the prevention of oxidative damage.

  Journal of agricultural and food chemistry 20100224

• Heme oxygenase reveals its strategy for catalyzing three successive oxygenation reactions.

  Accounts of chemical research 20100216

• Rational engineering of cytochromes P450 2B6 and 2B11 for enhanced stability: Insights into structural importance of residue 334.

  Archives of biochemistry and biophysics 20100215

• Reductive coupling of nitrogen monoxide (*NO) facilitated by heme/copper complexes.

  Inorganic chemistry 20100215

• The main role of inner histidines in the molecular mechanism of myoglobin oxidation catalyzed by copper compounds.

  Inorganic chemistry 20100215

• Crystallization of synthetic haemozoin (beta-haematin) nucleated at the surface of lipid particles.

  Dalton transactions (Cambridge, England : 2003) 20100207

• Nonadiabatic histidine dissociation of hexacoordinate heme in neuroglobin protein.

  The journal of physical chemistry. A 20100204

• Oxidative stress may modify zinc protoporphyrin/heme ratio in hematofluorometry.

  International journal of laboratory hematology 20100201

• Structure of the heme/hemoglobin outer membrane receptor ShuA from Shigella dysenteriae: heme binding by an induced fit mechanism.

  Proteins 20100201

• On the mechanism of SDS-induced protein denaturation.

  Biopolymers 20100201

• Structural characterization of a family of cytochromes c(7) involved in Fe(III) respiration by Geobacter sulfurreducens.

  Biochimica et biophysica acta 20100201

• Metabolism of haem in Caco-2 cells.

  Experimental physiology 20100201

• Visualizing changes in electron distribution in coupled chains of cytochrome bc(1) by modifying barrier for electron transfer between the FeS cluster and heme c(1).

  Biochimica et biophysica acta 20100201

• Influence of beta-galactose-specific mitochondrial lectins from prostate hyperplasic tissue on mitochondrial properties.

  Scandinavian journal of clinical and laboratory investigation 20100201

• L-glyceraldehyde 3-phosphate reductase from Escherichia coli is a heme binding protein.

  Bioorganic chemistry 20100201

• Meat and cancer.

  Meat science 20100201

• Ultrafast dynamics of resonance energy transfer in myoglobin: probing local conformation fluctuations.

  The journal of physical chemistry. B 20100128

• Trends in substrate hydroxylation reactions by heme and nonheme iron(IV)-oxo oxidants give correlations between intrinsic properties of the oxidant with barrier height.

  Journal of the American Chemical Society 20100127

• Successful stabilization of the elusive species {FeNO}8 in a heme model.

  Journal of the American Chemical Society 20100127

• EPR and Mössbauer spectroscopy show inequivalent hemes in tryptophan dioxygenase.

  Journal of the American Chemical Society 20100127

• A topological study of the decomposition of 6,7,8-trioxabicyclo[3.2.2]nonane induced by Fe(II): modeling the artemisinin reaction with heme.

  The journal of physical chemistry. B 20100121

• Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.

  Journal of the American Chemical Society 20100120

• Characterization of the haem oxygenase protein family in Arabidopsis thaliana reveals a diversity of functions.

  The Biochemical journal 20100115

• PpoC from Aspergillus nidulans is a fusion protein with only one active haem.

  The Biochemical journal 20100115

• Influence of the nitrogen donors on nonheme iron models of superoxide reductase: high-spin Fe(III)-OOR complexes.

  Journal of the American Chemical Society 20100113

• Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics.

  Journal of the American Chemical Society 20100113

• Mode of binding of the tuberculosis prodrug isoniazid to heme peroxidases: binding studies and crystal structure of bovine lactoperoxidase with isoniazid at 2.7 A resolution.

  The Journal of biological chemistry 20100108

• Fluoride-induced changes in haem biosynthesis pathway, neurological variables and tissue histopathology of rats.

  Journal of applied toxicology : JAT 20100101

• Site-specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b5-mediated heme reduction.

  Free radical biology & medicine 20100101

• Recombinant expression and redox properties of triheme c membrane-bound quinol peroxidase.

  FEMS microbiology letters 20100101

• Substrate specificity of three cytochrome c haem lyase isoenzymes from Wolinella succinogenes: unconventional haem c binding motifs are not sufficient for haem c attachment by NrfI and CcsA1.

  Molecular microbiology 20100101

• Determinants of ligand affinity and heme reactivity in H-NOX domains.

  Angewandte Chemie (International ed. in English) 20100101

• Relative roles of heme-irons and globin-thiols in the genesis of acellular hemoglobin mediated vasoconstriction.

  Artificial cells, blood substitutes, and immobilization biotechnology 20100101

• Mechanisms of cell protection by heme oxygenase-1.

  Annual review of pharmacology and toxicology 20100101

• Mutation of the heme axial ligand of Escherichia coli succinate-quinone reductase: implications for heme ligation in mitochondrial complex II from yeast.

  Biochimica et biophysica acta 20100101

• An evaluation of ondansetron binding interactions with human cytochrome P450 enzymes CYP3A4 and CYP2D6.

  Drug metabolism letters 20100101

• T-state stabilization of hemoglobin by nitric oxide to form alpha-nitrosyl heme causes constitutive release of ATP from human erythrocytes.

  Advances in experimental medicine and biology 20100101

• Lipoprotein modification and macrophage uptake: role of pathologic cholesterol transport in atherogenesis.

  Sub-cellular biochemistry 20100101

• Metagenomes from high-temperature chemotrophic systems reveal geochemical controls on microbial community structure and function.

  PloS one 20100101

• Characterization of a heme-regulated non-coding RNA encoded by the prrF locus of Pseudomonas aeruginosa.

  PloS one 20100101

• Identification of a siderophore utilization locus in nontypeable Haemophilus influenzae.

  BMC microbiology 20100101

• Measurements of heme levels and respiration rate in Salmonella enterica serovar typhimurium.

  Methods in molecular biology (Clifton, N.J.) 20100101

• [Acute intermittent porphyria: a diagnostic dilemma].

  Gastroenterologia y hepatologia 20100101

• Metabolic pathways in the apicoplast of apicomplexa.

  International review of cell and molecular biology 20100101

• From balsamic to healthy: traditional balsamic vinegar melanoidins inhibit lipid peroxidation during simulated gastric digestion of meat.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

• Synthesis of 5-hydroxyectoine from ectoine: crystal structure of the non-heme iron(II) and 2-oxoglutarate-dependent dioxygenase EctD.

  PloS one 20100101

• Explaining the atypical reaction profiles of heme enzymes with a novel mechanistic hypothesis and kinetic treatment.

  PloS one 20100101

• Heme and non-heme iron transporters in non-polarized and polarized cells.

  BMC cell biology 20100101

• Porcine ferrochelatase: the relationship between iron-removal reaction and the conversion of heme to Zn-protoporphyrin.

  Bioscience, biotechnology, and biochemistry 20100101

• Iron overload in diabetic retinopathy: a cause or a consequence of impaired mechanisms?

  Experimental diabetes research 20100101

• Increase on the initial soluble heme levels in acidic conditions is an important mechanism for spontaneous heme crystallization in vitro.

  PloS one 20100101

• Regulation and gene expression of heme synthesis under heavy metal exposure--review.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20100101

• Elevation of high-mobility group protein box-1 in serum correlates with severity of acute intracerebral hemorrhage.

  Mediators of inflammation 20100101

• Exploring neuroprotective drug therapies for intracerebral hemorrhage.

  Journal of pharmacological sciences 20100101

• The heme sensing response regulator HssR in Staphylococcus aureus but not the homologous RR23 in Listeria monocytogenes modulates susceptibility to the antimicrobial peptide plectasin.

  BMC microbiology 20100101

• Direct electrochemical analyses of human cytochromes b5 with a mutated heme pocket showed a good correlation between their midpoint and half wave potentials.

  Journal of biomedical science 20100101

• Comparative profiling of the transcriptional response to iron restriction in six serotypes of Actinobacillus pleuropneumoniae with different virulence potential.

  BMC genomics 20100101

• Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target.

  PloS one 20100101

• A novel pathway for the biosynthesis of heme in Archaea: genome-based bioinformatic predictions and experimental evidence.

  Archaea (Vancouver, B.C.) 20100101

• Physiological roles of ArcA, Crp, and EtrA and their interactive control on aerobic and anaerobic respiration in Shewanella oneidensis.

  PloS one 20100101

• [Efficacy and safety of the combined therapy with citicholine and actovegin in the acute period of ischemic stroke].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Effect of salinity on hydroxylamine oxidation in a marine ammonia-oxidizing gammaproteobacterium, Nitrosococcus oceani strain NS58: molecular and catalytic properties of tetraheme cytochrome c-554.

  Microbes and environments 20100101

• Communication between R481 and Cu(B) in cytochrome bo(3) ubiquinol oxidase from Escherichia coli.

  Biochemistry 20091229

• PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.

  Proceedings of the National Academy of Sciences of the United States of America 20091229

• Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site.

  The Journal of biological chemistry 20091225

• The distal pocket histidine residue in horse heart myoglobin directs the O-binding mode of nitrite to the heme iron.

  Journal of the American Chemical Society 20091223

• The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.

  The Journal of biological chemistry 20091218

• Relating the diffusion of small ligands in human neuroglobin to its structural and mechanical properties.

  The journal of physical chemistry. B 20091217

• Role of the cysteine protease interpain A of Prevotella intermedia in breakdown and release of haem from haemoglobin.

  The Biochemical journal 20091214

• Review: correlations between oxygen affinity and sequence classifications of plant hemoglobins.

  Biopolymers 20091201

• Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments.

  Journal of lipid research 20091201

• Effects of an onion by-product on bioactivity and safety markers in healthy rats.

  The British journal of nutrition 20091201

• Heme reversibly damps PERIOD2 rhythms in mouse suprachiasmatic nucleus explants.

  Neuroscience 20091201

• Molecular oxygen binding with alpha and beta subunits within the R quaternary state of human hemoglobin in solutions and porous sol-gel matrices.

  Biochimica et biophysica acta 20091201

• Interaction of artemisinins with oxyhemoglobin Hb-FeII, Hb-FeII, carboxyHb-FeII, heme-FeII, and carboxyheme FeII: significance for mode of action and implications for therapy of cerebral malaria.

  ChemMedChem 20091201

• Ligand orientation of human neuroglobin obtained from solution NMR and molecular dynamics simulation as compared with X-ray crystallography.

  Journal of inorganic biochemistry 20091201

• Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase.

  Bioorganic & medicinal chemistry letters 20091201

• Unusual stability of human neuroglobin at low pH--molecular mechanisms and biological significance.

  The FEBS journal 20091201

• (1)H, (15)N, and (13)C resonance assignments of the 2/2 hemoglobin from the cyanobacterium Synechococcus sp. PCC 7002 in the ferric bis-histidine state.

  Biomolecular NMR assignments 20091201

• A physiologically significant role in nitrite reduction of the CcoP subunit of the cytochrome oxidase cbb3 from Neisseria gonorrhoeae.

  FEMS microbiology letters 20091201

• Protein assay for heme oxygenase-1 (HO-1) induced by chemicals in HepG2 cells.

  The Journal of toxicological sciences 20091201

• Crystallization and preliminary X-ray crystallographic analysis of a new crystal form of hydroxylamine oxidoreductase from Nitrosomonas europaea.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20091201

• Metal ion facilitated dissociation of heme from b-type heme proteins.

  Journal of the American Chemical Society 20091125

• X-ray crystal structure of michaelis complex of aldoxime dehydratase.

  The Journal of biological chemistry 20091113

• Heme transfer to the bacterial cell envelope occurs via a secreted hemophore in the Gram-positive pathogen Bacillus anthracis.

  The Journal of biological chemistry 20091113

• Ligand and substrate migration in human indoleamine 2,3-dioxygenase.

  The Journal of biological chemistry 20091113

• Control of electrochemical and ferryloxy formation kinetics of cyt P450s in polyion films by heme iron spin state and secondary structure.

  Journal of the American Chemical Society 20091111

• Ibuprofen impairs allosterically peroxynitrite isomerization by ferric human serum heme-albumin.

  The Journal of biological chemistry 20091106

• Redox effects on the coordination geometry and heme conformation of bis(N-methylimidazole) complexes of superstructured Fe-porphyrins. A spectroscopic study.

  Inorganic chemistry 20091102

• Theoretical investigations on the hydrolysis pathway of tin verdoheme complexes: elucidation of tin's ring opening inhibition role.

  Journal of molecular modeling 20091101

• Identification of heme propionate vibrational modes in the resonance Raman spectra of cytochrome c oxidase.

  Analytical biochemistry 20091101

• Microperoxidase 11: a model system for porphyrin networks and heme-protein interactions.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20091101

• Expression of chlorophyll synthase is also involved in feedback-control of chlorophyll biosynthesis.

  Plant molecular biology 20091101

• Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein.

  The Journal of pharmacology and experimental therapeutics 20091101

• Inactivation of cystathionine beta-synthase with peroxynitrite.

  Archives of biochemistry and biophysics 20091101

• d(1) haem biogenesis - assessing the roles of three nir gene products.

  The FEBS journal 20091101

• Meat and meat-related compounds and risk of prostate cancer in a large prospective cohort study in the United States.

  American journal of epidemiology 20091101

• IlsA, a unique surface protein of Bacillus cereus required for iron acquisition from heme, hemoglobin and ferritin.

  PLoS pathogens 20091101

• Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species.

  Journal of cellular biochemistry 20091015

• Effective electrochemical method for investigation of hemoglobin unfolding based on the redox property of heme groups at glassy carbon electrodes.

  Analytical chemistry 20091015

• Heterogeneous electron transfer of a two-centered heme protein: redox and electrocatalytic properties of surface-immobilized cytochrome C(4).

  The journal of physical chemistry. B 20091015

• EPR and ENDOR characterization of the reactive intermediates in the generation of NO by cryoreduced oxy-nitric oxide synthase from Geobacillus stearothermophilus.

  Journal of the American Chemical Society 20091014

• The 1.5-A structure of XplA-heme, an unusual cytochrome P450 heme domain that catalyzes reductive biotransformation of royal demolition explosive.

  The Journal of biological chemistry 20091009

• Carbon monoxide and nitrogen monoxide ligand dynamics in synthetic heme and heme-copper complex systems.

  Journal of the American Chemical Society 20091007

• FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus.

  Organic & biomolecular chemistry 20091007

• Haemopexin affects iron distribution and ferritin expression in mouse brain.

  Journal of cellular and molecular medicine 20091001

• Critical structural role of R481 in cytochrome c oxidase from Rhodobacter sphaeroides.

  Biochimica et biophysica acta 20091001

• Identification and characterization of a cytochrome b559 Synechocystis 6803 mutant spontaneously generated from DCMU-inhibited photoheterotrophical growth conditions.

  Biochimica et biophysica acta 20091001

• The FG loop of a heme-based gas sensor enzyme, Ec DOS, functions in heme binding, autoxidation and catalysis.

  Journal of inorganic biochemistry 20091001

• The Pseudomonas aeruginosa nirE gene encodes the S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase required for heme d(1) biosynthesis.

  The FEBS journal 20091001

• The role of arginine-127 at the proximal NO-binding site in determining the electronic structure and function of 5-coordinate NO-heme in cytochrome c' of Rhodobacter sphaeroides.

  Biochemistry 20090929

• Kinetics and activation parameters for oxidations of styrene by Compounds I from the cytochrome P450(BM-3) (CYP102A1) heme domain and from CYP119.

  Biochemistry 20090929

• Isocyanides inhibit human heme oxygenases at the verdoheme stage.

  Biochemistry 20090922

• Essential role of proximal histidine-asparagine interaction in mammalian peroxidases.

  The Journal of biological chemistry 20090918

• Surf1, associated with Leigh syndrome in humans, is a heme-binding protein in bacterial oxidase biogenesis.

  The Journal of biological chemistry 20090918

• Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction.

  International journal of cancer 20090915

• Superoxide radical protects liposome-contained cytochrome c against oxidative damage promoted by peroxynitrite and free radicals.

  Free radical biology & medicine 20090915

• Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha.

  Genes & development 20090915

• Structure and catalytic behavior of myoglobin adsorbed onto nanosized hydrotalcites.

  Langmuir : the ACS journal of surfaces and colloids 20090915

• Regulation of interdomain electron transfer in the NOS output state for NO production.

  Dalton transactions (Cambridge, England : 2003) 20090914

• Ibuprofen modulates allosterically NO dissociation from ferrous nitrosylated human serum heme-albumin by binding to three sites.

  Biochemical and biophysical research communications 20090911

• Cardiovascular consequences when nitric oxide and lipid signaling converge.

  Circulation research 20090911

• Kinetic studies of lipid oxidation induced by hemoglobin measured by consumption of dissolved oxygen in a liposome model system.

  Journal of agricultural and food chemistry 20090909

• Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopy.

  Journal of the American Chemical Society 20090909

• Heme cavity dynamics of photodissociated CO from ba3-cytochrome c oxidase: the role of ring-D propionate.

  The journal of physical chemistry. B 20090903

• Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase.

  Journal of the American Chemical Society 20090902

• The interplay between iron and zinc metabolism in Aspergillus fumigatus.

  Fungal genetics and biology : FG & B 20090901

• 1H and 13C NMR spectroscopic studies of the ferriheme resonances of three low-spin complexes of wild-type nitrophorin 2 and nitrophorin 2(V24E) as a function of pH.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090901

• Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy.

  American journal of respiratory cell and molecular biology 20090901

• Effects of urea and acetic acid on the heme axial ligation structure of ferric myoglobin at very acidic pH.

  Archives of biochemistry and biophysics 20090901

• Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.

  Bioorganic & medicinal chemistry 20090901

• [Neurological complications of acute intermittent porphyria precipitated by porphyrinogenic drugs and efficiency of heme-arginate treatment].

  La Tunisie medicale 20090901

• Effect of the redox-dependent ionization state of the heme propionic acid side chain on the entropic contribution to the redox potential of Pseudomonas aeruginosa cytochrome c551.

  Biochemistry 20090825

• Heme/O2/*NO nitric oxide dioxygenase (NOD) reactivity: phenolic nitration via a putative heme-peroxynitrite intermediate.

  Journal of the American Chemical Society 20090819

• Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4.

  Archives of biochemistry and biophysics 20090815

• Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.

  Bioorganic & medicinal chemistry letters 20090815

• The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols.

  The Journal of biological chemistry 20090814

• Binding of Pseudomonas aeruginosa apobacterioferritin-associated ferredoxin to bacterioferritin B promotes heme mediation of electron delivery and mobilization of core mineral iron.

  Biochemistry 20090811

• Measurements of heme relaxation and ligand recombination in strong magnetic fields.

  The journal of physical chemistry. B 20090806

• Properties of Arg481 mutants of the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides suggest that neither R481 nor the nearby D-propionate of heme a3 is likely to be the proton loading site of the proton pump.

  Biochemistry 20090804

• Superoxide oxidase and reductase activity of cytochrome b559 in photosystem II.

  Biochimica et biophysica acta 20090801

• Preparation of a biologically active apo-cytochrome b5 via heterologous expression in Escherichia coli.

  Protein expression and purification 20090801

• Verdoheme formation in Proteus mirabilis catalase.

  Biochimica et biophysica acta 20090801

• Treatment of symptomatic polyneuropathy with actovegin in type 2 diabetic patients.

  Diabetes care 20090801

• The acute porphyrias: a diagnostic and therapeutic challenge in internal and emergency medicine.

  Internal and emergency medicine 20090801

• Oxidative aromatization of 1,4-dihydropyridines and pyrazolines using HbA-H(2)O(2): An efficient biomimetic catalyst system providing metabolites of drug candidates.

  Bioorganic & medicinal chemistry letters 20090801

• Effect of processed and red meat on endogenous nitrosation and DNA damage.

  Carcinogenesis 20090801

• Reaction of nitric oxide with the oxidized di-heme and heme-copper oxygen-reducing centers of terminal oxidases: Different reaction pathways and end-products.

  Journal of inorganic biochemistry 20090801

• Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.

  Cell metabolism 20090801

• Heme regulatory motifs in heme oxygenase-2 form a thiol/disulfide redox switch that responds to the cellular redox state.

  The Journal of biological chemistry 20090731

• Is the redox state of the ci heme of the cytochrome b6f complex dependent on the occupation and structure of the Qi site and vice versa?

  The Journal of biological chemistry 20090731

• Binding modes of aromatic ligands to mammalian heme peroxidases with associated functional implications: crystal structures of lactoperoxidase complexes with acetylsalicylic acid, salicylhydroxamic acid, and benzylhydroxamic acid.

  The Journal of biological chemistry 20090724

• Guanidine hydrochloride-induced unfolding of the three heme coordination states of the CO-sensing transcription factor, CooA.

  Biochemistry 20090721

• Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complex.

  The Journal of biological chemistry 20090717

• Caenorhabditis elegans and human dual oxidase 1 (DUOX1) 'peroxidase' domains: insights into heme binding and catalytic activity.

  The Journal of biological chemistry 20090710

• Antioxidant activity of wine pigments derived from anthocyanins: hydrogen transfer reactions to the dpph radical and inhibition of the heme-induced peroxidation of linoleic acid.

  Journal of agricultural and food chemistry 20090708

• Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteasomal degradation.

  Circulation research 20090702

• Modeling of peroxide activation in artemisinin derivatives by serial docking.

  Journal of molecular modeling 20090701

• Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.

  European journal of medicinal chemistry 20090701

• The prominent conformational plasticity of lactoperoxidase: a chemical and pH stability analysis.

  Biochimica et biophysica acta 20090701

• Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells.

  Mitochondrion 20090701

• Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease.

  Free radical biology & medicine 20090701

• Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides.

  The Biochemical journal 20090701

• Evidence for the presence of prostaglandin H synthase like enzyme in female Setaria cervi and its inhibition by diethylcarbamazine.

  Acta tropica 20090701

• Heme arginate suppresses cardiac lesions and hypertrophy in deoxycorticosterone acetate-salt hypertension.

  Experimental biology and medicine (Maywood, N.J.) 20090701

• Benzylic oxidation of gemfibrozil-1-O-beta-glucuronide by P450 2C8 leads to heme alkylation and irreversible inhibition.

  Chemical research in toxicology 20090701

• Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.

  British journal of pharmacology 20090701

• Role of Phe113 at the distal side of the heme domain of an oxygen-sensor (Ec DOS) in the characterization of the heme environment.

  Journal of inorganic biochemistry 20090701

• Trp180 of endothelial NOS and Trp56 of bacterial saNOS modulate sigma bonding of the axial cysteine to the heme.

  Journal of inorganic biochemistry 20090701

• Electron transfer processes in subunit I mutants of cytochrome bo quinol oxidase in Escherichia coli.

  Bioscience, biotechnology, and biochemistry 20090701

• The heme biosynthetic pathway of the obligate Wolbachia endosymbiont of Brugia malayi as a potential anti-filarial drug target.

  PLoS neglected tropical diseases 20090701

• Longitudinal study of a mouse model of familial porphyria cutanea tarda.

  Cellular and molecular biology (Noisy-le-Grand, France) 20090701

• The expression of protoporphyrinogen oxidase in human tissues.

  Cellular and molecular biology (Noisy-le-Grand, France) 20090701

• Sevoflurane: its action on heme metabolism and Phase I drug metabolizing system.

  Cellular and molecular biology (Noisy-le-Grand, France) 20090701

• High-resolution structural analysis of a novel octaheme cytochrome c nitrite reductase from the haloalkaliphilic bacterium Thioalkalivibrio nitratireducens.

  Journal of molecular biology 20090626

• Dipyridamole inhibits cobalt chloride-induced osteopontin expression in NRK52E cells.

  European journal of pharmacology 20090624

• Magnetic interactions sense changes in distance between heme b(L) and the iron-sulfur cluster in cytochrome bc(1).

  Biochemistry 20090623

• Redox-dependent conformational changes in cytochrome C oxidase suggest a gating mechanism for proton uptake.

  Biochemistry 20090616

• Two synthetic peptides corresponding to the proximal heme-binding domain and CD1 domain of human endothelial nitric-oxide synthase inhibit the oxygenase activity by interacting with CaM.

  Archives of biochemistry and biophysics 20090615

• Direct evidence for mode-specific vibrational energy relaxation from quantum time-dependent perturbation theory. III. The nu(4) and nu(7) modes of nonplanar nickel porphyrin models.

  The Journal of chemical physics 20090607

• Soluble guanylate cyclase: not a dull enzyme.

  Circulation 20090602

• Role for copper in the cellular and regulatory effects of heme-hemopexin.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20090601

• Mitochondrial ABC proteins in health and disease.

  Biochimica et biophysica acta 20090601

• Post-transcriptional regulation of the expression of ferrochelatase by its variant mRNA.

  Journal of biochemistry 20090601

• Limited reversibility of transmembrane proton transfer assisting transmembrane electron transfer in a dihaem-containing succinate:quinone oxidoreductase.

  Biochimica et biophysica acta 20090601

• Role of phospholipids in respiratory cytochrome bc(1) complex catalysis and supercomplex formation.

  Biochimica et biophysica acta 20090601

• Probing the haem d-binding site in cytochrome bd quinol oxidase by site-directed mutagenesis.

  Journal of biochemistry 20090601

• Linking conformation change to hemoglobin activation via chain-selective time-resolved resonance Raman spectroscopy of protoheme/mesoheme hybrids.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090601

• On the fate of extracellular hemoglobin and heme in brain.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090601

• Cloning, expression, and biochemical properties of CPOX4, a genetic variant of coproporphyrinogen oxidase that affects susceptibility to mercury toxicity in humans.

  Toxicological sciences : an official journal of the Society of Toxicology 20090601

• High resolution crystal structure of Paracoccus denitrificans cytochrome c oxidase: new insights into the active site and the proton transfer pathways.

  Biochimica et biophysica acta 20090601

• Auxin-responsive genes AIR12 code for a new family of plasma membrane b-type cytochromes specific to flowering plants.

  Plant physiology 20090601

• Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia.

  Nature genetics 20090601

• Potential application of the recombinant Escherichia coli-synthesized heme as a bioavailable iron source.

  Journal of microbiology and biotechnology 20090601

• Heme environment in HmuY, the heme-binding protein of Porphyromonas gingivalis.

  Biochemical and biophysical research communications 20090529

• The mechanism of oxidative halophenol dehalogenation by Amphitrite ornata dehaloperoxidase is initiated by H2O2 binding and involves two consecutive one-electron steps: role of ferryl intermediates.

  Biochemistry 20090526

• Discovery of dual function acridones as a new antimalarial chemotype.

  Nature 20090514

• Structural insight into the heme-based redox sensing by DosS from Mycobacterium tuberculosis.

  The Journal of biological chemistry 20090508

• Heme d1 nitrosyl complex of cd1 nitrite reductase studied by high-field-pulse electron paramagnetic resonance spectroscopy.

  Inorganic chemistry 20090504

• Molecular and functional characteristics of proton-coupled folate transporter.

  Journal of pharmaceutical sciences 20090501

• Engineering heme binding sites in monomeric rop.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090501

• Probing structure of heme A synthase from Bacillus subtilis by site-directed mutagenesis.

  Journal of biochemistry 20090501

• Effects of replacement of low-spin haem b by haem O on Escherichia coli cytochromes bo and bd quinol oxidases.

  Journal of biochemistry 20090501

• Over-expression and characterization of Bacillus subtilis heme O synthase.

  Journal of biochemistry 20090501

• Intramolecular electron transfer processes in Cu(B)-deficient cytochrome bo studied by pulse radiolysis.

  Journal of biochemistry 20090501

• Antimalarial drugs and heme in detergent micelles: An NMR study.

  Journal of inorganic biochemistry 20090501

• Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation.

  Journal of inorganic biochemistry 20090501

• Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach.

  Toxicology and applied pharmacology 20090501

• Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine.

  Arteriosclerosis, thrombosis, and vascular biology 20090501

• Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P450.

  The Journal of biological chemistry 20090501

• Peroxisome proliferator-activated receptor alpha controls hepatic heme biosynthesis through ALAS1.

  Journal of molecular biology 20090501

• Ineffective erythropoiesis and thalassemias.

  Current opinion in hematology 20090501

• Peroxide-dependent formation of a covalent link between Trp51 and the heme in cytochrome c peroxidase.

  Biochemistry 20090428

• Role of substrate functional groups in binding to nitric oxide synthase.

  Biochemical and biophysical research communications 20090424

• Active site of cytochrome cbb3.

  The Journal of biological chemistry 20090424

• Experimental validation and complexity of miRNA-mRNA target interaction during zebrafish primitive erythropoiesis.

  Biochemical and biophysical research communications 20090417

• Crystal structure of rat haem oxygenase-1 in complex with ferrous verdohaem: presence of a hydrogen-bond network on the distal side.

  The Biochemical journal 20090415

• Catalytic reduction of O2 by cytochrome C using a synthetic model of cytochrome C oxidase.

  Journal of the American Chemical Society 20090415

• Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.

  Journal of cell science 20090415

• Activation parameters for heme-NO binding in alcaligenes xylosoxidans cytochrome c': the putative dinitrosyl intermediate forms via a dissociative mechanism.

  Journal of the American Chemical Society 20090408

• Low-frequency heme, iron-ligand, and ligand modes of imidazole and imidazolate complexes of iron protoporphyrin and microperoxidase in aqueous solution. An analysis by far-infrared difference spectroscopy.

  The journal of physical chemistry. B 20090402

• Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1).

  The British journal of nutrition 20090401

• Kinetic characterization of recombinant human cystathionine beta-synthase purified from E. coli.

  Protein expression and purification 20090401

• Localisation of Plasmodium falciparum uroporphyrinogen III decarboxylase of the heme-biosynthetic pathway in the apicoplast and characterisation of its catalytic properties.

  International journal for parasitology 20090401

• Variant c-type cytochromes as probes of the substrate specificity of the E. coli cytochrome c maturation (Ccm) apparatus.

  The Biochemical journal 20090401

• 15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS.

  Carcinogenesis 20090401

• Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6.

  The Journal of pharmacology and experimental therapeutics 20090401

• Heme-binding storage proteins in the Chelicerata.

  Journal of insect physiology 20090401

• Purification and characterization of a chlorite dismutase from Pseudomonas chloritidismutans.

  FEMS microbiology letters 20090401

• Comparison of direct and mediated electron transfer for cellobiose dehydrogenase from Phanerochaete sordida.

  Analytical chemistry 20090401

• Reassessment of the reaction mechanism in the heme dioxygenases.

  Journal of the American Chemical Society 20090401

• Structure and heme binding properties of Escherichia coli O157:H7 ChuX.

  Protein science : a publication of the Protein Society 20090401

• Lipopolysaccharide biosynthesis-related genes are required for colony pigmentation of Porphyromonas gingivalis.

  Microbiology (Reading, England) 20090401

• Design of recombinant hemoglobins for use in transfusion fluids.

  Critical care clinics 20090401

• Structure-based CoMFA as a predictive model - CYP2C9 inhibitors as a test case.

  Journal of chemical information and modeling 20090401

• Intracellular substrates of a heme-containing ascorbate oxidase in Pleurotus ostreatus.

  Journal of microbiology (Seoul, Korea) 20090401

• Ilicicolin Inhibition and Binding at Center N of the Dimeric Cytochrome bc1 Complex Reveal Electron Transfer and Regulatory Interactions between Monomers.

  The Journal of biological chemistry 20090327

• The binding of lignans, flavonoids and coumestrol to CYP450 aromatase: a molecular modelling study.

  Molecular and cellular endocrinology 20090325

• Design and engineering of an O(2) transport protein.

  Nature 20090319

• Different modes of binding of mono-, di-, and trihalogenated phenols to the hemoglobin dehaloperoxidase from Amphitrite ornata.

  Biochemistry 20090317

• Comparative analysis of gene expression changes mediated by individual constituents of hemozoin.

  Chemical research in toxicology 20090316

• 4,4-Difluorinated analogues of l-arginine and N(G)-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase.

  Bioorganic & medicinal chemistry letters 20090315

• Molecular biosensor based on a coordinated iron complex.

  The Journal of chemical physics 20090314

• Role of the oxyferrous heme intermediate and distal side adduct radical in the catalase activity of Mycobacterium tuberculosis KatG revealed by the W107F mutant.

  The Journal of biological chemistry 20090313

• An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG).

  The Journal of biological chemistry 20090313

• Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.

  Journal of medicinal chemistry 20090312

• Comparative computational analysis of active and inactive cofactors of nitric oxide synthase.

  The journal of physical chemistry. B 20090312

• Direct evidence for mode-specific vibrational energy relaxation from quantum time-dependent perturbation theory. II. The nu(4) and nu(7) modes of iron-protoporphyrin IX and iron porphine.

  The Journal of chemical physics 20090307

• The oligomeric assembly of the novel haem-degrading protein HbpS is essential for interaction with its cognate two-component sensor kinase.

  Journal of molecular biology 20090306

• Why do cysteine dioxygenase enzymes contain a 3-His ligand motif rather than a 2His/1Asp motif like most nonheme dioxygenases?

  The journal of physical chemistry. A 20090305

• Ultrafast proteinquake dynamics in cytochrome c.

  Journal of the American Chemical Society 20090304

• Probing the heme-binding site of the cytochrome c maturation protein CcmE.

  Biochemistry 20090303

• Biochemical characterization and mutational analysis of the mononuclear non-haem Fe2+ site in Dke1, a cupin-type dioxygenase from Acinetobacter johnsonii.

  The Biochemical journal 20090301

• Covalent heme attachment to the protein in human heme oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand.

  Journal of inorganic biochemistry 20090301

• Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis.

  Haematologica 20090301

• Comparison of the crystal structure and function to wild-type and His25Ala mutant human heme oxygenase-1.

  International journal of molecular medicine 20090301

• Plasma porphobilinogen as a sensitive biomarker to monitor the clinical and therapeutic course of acute intermittent porphyria attacks.

  European journal of internal medicine 20090301

• Flexible structure of cytochrome P450: promiscuity of ligand binding in the CYP3A4 heme pocket.

  Anticancer research 20090301

• Photodissociation of isolated ferric heme and heme-His cations in an electrostatic ion storage ring.

  The journal of physical chemistry. A 20090226

• Highly reactive porphyrin-iron-oxo derivatives produced by photolyses of metastable porphyrin-iron(IV) diperchlorates.

  Journal of the American Chemical Society 20090225

• Structural basis of heme binding in the Cu,Zn superoxide dismutase from Haemophilus ducreyi.

  Journal of molecular biology 20090220

• Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and imidazole complexes.

  Journal of the American Chemical Society 20090218

• Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q.

  Biophysical journal 20090218

• 5-aminolevulinate synthase: catalysis of the first step of heme biosynthesis.

  Cellular and molecular biology (Noisy-le-Grand, France) 20090216

• New insights into the role of Fur proteins: FurB (All2473) from Anabaena protects DNA and increases cell survival under oxidative stress.

  The Biochemical journal 20090215

• HisE11 and HisF8 provide bis-histidyl heme hexa-coordination in the globin domain of Geobacter sulfurreducens globin-coupled sensor.

  Journal of molecular biology 20090213

• Mapping the interaction between the hemophore HasA and its outer membrane receptor HasR using CRINEPT-TROSY NMR spectroscopy.

  Journal of the American Chemical Society 20090211

• A role of the heme-7-propionate side chain in cytochrome P450cam as a gate for regulating the access of water molecules to the substrate-binding site.

  Journal of the American Chemical Society 20090204

• Geometric constraints for porphyrin binding in helical protein binding sites.

  Proteins 20090201

• PBRL, a putative peripheral benzodiazepine receptor, in primitive erythropoiesis.

  Gene expression patterns : GEP 20090201

• Replacement of the axial histidine heme ligand with cysteine in nitrophorin 1: spectroscopic and crystallographic characterization.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090201

• Reversible two-step unfolding of heme-human serum albumin: a (1)H-NMR relaxometric and circular dichroism study.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090201

• Trypanosoma brucei brucei: effects of ferrous iron and heme on ecto-nucleoside triphosphate diphosphohydrolase activity.

  Experimental parasitology 20090201

• Tuning of functional heme reduction potentials in Shewanella fumarate reductases.

  Biochimica et biophysica acta 20090201

• Temporal signaling and differential expression of Bordetella iron transport systems: the role of ferrimones and positive regulators.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20090201

• Heme oxygenase-1: from biology to therapeutic potential.

  Trends in molecular medicine 20090201

• Control of oxidative reactions of hemoglobin in the design of blood substitutes: role of the ascorbate-glutathione antioxidant system.

  Artificial organs 20090201

• The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.

  PLoS biology 20090201

• The novel heme oxygenase-like protein from Plasmodiumfalciparum converts heme to bilirubin IXalpha in the apicoplast.

  FEBS letters 20090122

• Competition between reversible aggregation and loop formation in denatured iso-1-cytochrome c.

  Biochemistry 20090120

• A one-residue switch reverses the orientation of a heme b cofactor. Investigations of the ferriheme NO transporters nitrophorin 2 and 7 from the blood-feeding insect Rhodnius prolixus.

  Biochemistry 20090120

• The second step of the nitric oxide synthase reaction: evidence for ferric-peroxo as the active oxidant.

  Journal of the American Chemical Society 20090114

• First half-reaction mechanism of nitric oxide synthase: the role of proton and oxygen coupled electron transfer in the reaction by quantum mechanics/molecular mechanics.

  The journal of physical chemistry. B 20090108

• Quantum mechanical investigations of heme structure and vibrational spectra: effects of conformation, oxidation state, and electric field.

  Langmuir : the ACS journal of surfaces and colloids 20090106

• Stability of the heme Fe-N-terminal amino group coordination bond in denatured cytochrome c.

  Inorganic chemistry 20090105

• Nitration of solvent-exposed tyrosine 74 on cytochrome c triggers heme iron-methionine 80 bond disruption. Nuclear magnetic resonance and optical spectroscopy studies.

  The Journal of biological chemistry 20090102

• The role of the cytoplasmic heme-binding protein (PhuS) of Pseudomonas aeruginosa in intracellular heme trafficking and iron homeostasis.

  The Journal of biological chemistry 20090102

• Novel haem co-ordination variants of flavocytochrome P450BM3.

  The Biochemical journal 20090101

• Stability enhancement of cytochrome c through heme deprotonation and mutations.

  Biophysical chemistry 20090101

• PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.

  Pharmacology & therapeutics 20090101

• The role of the heme distal ligand in the post-translational modification of Synechocystis hemoglobin.

  Journal of inorganic biochemistry 20090101

• Inhibition of heme synthesis alters Amyloid Precursor Protein processing.

  Journal of neural transmission (Vienna, Austria : 1996) 20090101

• Chaperone-like activity of heme group against amyloid-like fibril formation by hen egg ovalbumin: possible mechanism of action.

  International journal of biological macromolecules 20090101

• NO-independent, haem-dependent soluble guanylate cyclase stimulators.

  Handbook of experimental pharmacology 20090101

• NO- and haem-independent soluble guanylate cyclase activators.

  Handbook of experimental pharmacology 20090101

• Nutritional value of traditional Italian meat-based dishes: influence of cooking methods and recipe formulation.

  International journal of food sciences and nutrition 20090101

• The effect of an exon 12 polymorphism of the human thromboxane synthase (CYP5A1) gene in stroke patients.

  Medical science monitor : international medical journal of experimental and clinical research 20090101

• The iron/heme regulated genes of Haemophilus influenzae: comparative transcriptional profiling as a tool to define the species core modulon.

  BMC genomics 20090101

• Crystallization and diffraction patterns of the oxy and cyano forms of the Lucina pectinata haemoglobins complex.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20090101

• The bilirubin level is negatively correlated with the incidence of hypertension in normotensive Korean population.

  Journal of Korean medical science 20090101

• siRNA-mediated knockdown of the heme synthesis and degradation pathways: modulation of treatment effect of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines.

  Photochemistry and photobiology 20090101

• Anemia after bariatric surgery: more than just iron deficiency.

  Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 20090101

• How does the axial ligand of cytochrome P450 biomimetics influence the regioselectivity of aliphatic versus aromatic hydroxylation?

  Chemistry (Weinheim an der Bergstrasse, Germany) 20090101

• Formation of heme-iron complexes with nitric oxide (NO) and peroxynitrite (ONOO-) after ultraviolet radiation as a protective mechanism in rat skin.

  In vivo (Athens, Greece) 20090101

• High-level production of recombinant Arenicola marina globin chains in Escherichia coli: a new generation of blood substitute.

  Artificial cells, blood substitutes, and immobilization biotechnology 20090101

• [Differential approaches to intensive care of patients with severe acute porphyria].

  Anesteziologiia i reanimatologiia 20090101

• Application of the linear interaction energy method for rational design of artemisinin analogues as haeme polymerisation inhibitors.

  SAR and QSAR in environmental research 20090101

• [A novel strategy to design specific iNOS inhibitors].

  Medecine sciences : M/S 20090101

• Assessing the contribution of heme-iron acquisition to Staphylococcus aureus pneumonia using computed tomography.

  PloS one 20090101

• Alpha-glucosidase promotes hemozoin formation in a blood-sucking bug: an evolutionary history.

  PloS one 20090101

• Characterization of heme coordination structure in heme-DNA complex possessing gaseous molecule as an exogenous ligand.

  Nucleic acids symposium series (2004) 20090101

• An ATP and oxalate generating variant tricarboxylic acid cycle counters aluminum toxicity in Pseudomonas fluorescens.

  PloS one 20090101

• Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target.

  PloS one 20090101

• [Antioxidant effects of L-arginine in the rat heart in experimental rhabdomyolysis].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20090101

• Regulation of heme synthesis and proteasomal activity by copper: possible implications for Wilson's disease.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20090101

• Stringency of the 2-His-1-Asp active-site motif in prolyl 4-hydroxylase.

  PloS one 20090101

• Crystal structure of Bfr A from Mycobacterium tuberculosis: incorporation of selenomethionine results in cleavage and demetallation of haem.

  PloS one 20090101

• [Effect of L-arginine on pro- and antioxidant status of the rat vessels and lungs in experimental rhabdomyolysis].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20090101

• Unusual flexibility of distal and proximal histidine residues in the haem pocket of Drosophila melanogaster haemoglobin.

  Metallomics : integrated biometal science 20090101

• Cytochrome P450 2C9 type II binding studies on quinoline-4-carboxamide analogues.

  Journal of medicinal chemistry 20081225

• Prostaglandin D2 induces heme oxygenase-1 mRNA expression through the DP2 receptor.

  Biochemical and biophysical research communications 20081219

• How do azoles inhibit cytochrome P450 enzymes? A density functional study.

  The journal of physical chemistry. A 20081218

• QM/MM modeling of benzene hydroxylation in human cytochrome P450 2C9.

  The journal of physical chemistry. A 20081218

• Electron transfer in the P450cam/PDX complex. The QM/MM e-pathway.

  The journal of physical chemistry. A 20081218

• Compound I in heme thiolate enzymes: a comparative QM/MM study.

  The journal of physical chemistry. A 20081218

• Ligand binding to the Fe(III)-protoporphyrin IX complex of phosphodiesterase from Escherichia coli (Ec DOS) markedly enhances catalysis of cyclic di-GMP: roles of Met95, Arg97, and Phe113 of the putative heme distal side in catalytic regulation and ligand binding.

  Biochemistry 20081216

• Identification and characterization of VPO1, a new animal heme-containing peroxidase.

  Free radical biology & medicine 20081215

• Vibrational assignments of six-coordinate ferrous heme nitrosyls: new insight from nuclear resonance vibrational spectroscopy.

  Inorganic chemistry 20081215

• Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone.

  The Journal of biological chemistry 20081212

• Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation.

  Journal of medicinal chemistry 20081211

• Heme-mediated production of free radicals via preformed lipid hydroperoxide fragmentation.

  Journal of agricultural and food chemistry 20081210

• Mapping protein electron transfer pathways with QM/MM methods.

  Journal of the Royal Society, Interface 20081206

• The crystal structure of Desulfovibrio vulgaris dissimilatory sulfite reductase bound to DsrC provides novel insights into the mechanism of sulfate respiration.

  The Journal of biological chemistry 20081205

• Resonance Raman interrogation of the consequences of heme rotational disorder in myoglobin and its ligated derivatives.

  Biochemistry 20081202

• Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway.

  European journal of medicinal chemistry 20081201

• Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin.

  Molecular and cellular biochemistry 20081201

• Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia.

  Journal of thrombosis and haemostasis : JTH 20081201

• The hmuUV genes of Sinorhizobium meliloti 2011 encode the permease and ATPase components of an ABC transport system for the utilization of both haem and the hydroxamate siderophores, ferrichrome and ferrioxamine B.

  Molecular microbiology 20081201

• Cytochrome c6A: discovery, structure and properties responsible for its low haem redox potential.

  Biochemical Society transactions 20081201

• Structural and functional comparison of 2-His-1-carboxylate and 3-His metallocentres in non-haem iron(II)-dependent enzymes.

  Biochemical Society transactions 20081201

• Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway.

  The FEBS journal 20081201

• The chemistry and biochemistry of heme c: functional bases for covalent attachment.

  Natural product reports 20081201

• Manifestation of psychiatric behaviors in a mouse model of griseofulvin-induced hepatic porphyria.

  The Journal of toxicological sciences 20081201

• Complex formation between protoporphyrinogen IX oxidase and ferrochelatase during haem biosynthesis in Thermosynechococcus elongatus.

  Microbiology (Reading, England) 20081201

• Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase.

  The Journal of biological chemistry 20081128

• Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates.

  The Journal of biological chemistry 20081128

• Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.

  The Journal of biological chemistry 20081128

• 2.3 A X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis.

  Biochemistry 20081125

• A twist on heme signaling.

  ACS chemical biology 20081121

• Probing the function of heme distortion in the H-NOX family.

  ACS chemical biology 20081121

• Binding of CO, NO, and O2 to heme by density functional and multireference ab initio calculations.

  The journal of physical chemistry. A 20081120

• Electronic structure of six-coordinate iron(III)-porphyrin NO adducts: the elusive iron(III)-NO(radical) state and its influence on the properties of these complexes.

  Journal of the American Chemical Society 20081119

• Modulation of the ligand-field anisotropy in a series of ferric low-spin cytochrome c mutants derived from Pseudomonas aeruginosa cytochrome c-551 and Nitrosomonas europaea cytochrome c-552: a nuclear magnetic resonance and electron paramagnetic resonance study.

  Journal of the American Chemical Society 20081119

• Changes in quaternary structure in the signaling mechanisms of PAS domains.

  Biochemistry 20081118

• Ligand preference and orientation in b- and c-type heme-binding proteins.

  Proteins 20081115

• hem6: an ENU-induced recessive hypochromic microcytic anemia mutation in the mouse.

  Blood 20081115

• Protein and electrode engineering for the covalent immobilization of P450 BMP on gold.

  Analytical chemistry 20081115

• The IsdC protein from Staphylococcus aureus uses a flexible binding pocket to capture heme.

  The Journal of biological chemistry 20081114

• Variation of the oxidation state of verdoheme in the heme oxygenase reaction.

  Biochemical and biophysical research communications 20081114

• Density functional studies on thromboxane biosynthesis: mechanism and role of the heme-thiolate system.

  Chemistry, an Asian journal 20081113

• MG-132 inhibits the TCDD-mediated induction of Cyp1a1 at the catalytic activity but not the mRNA or protein levels in Hepa 1c1c7 cells.

  Toxicology letters 20081110

• UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis.

  The Journal of biological chemistry 20081107

• Proton-dependent electron transfer from CuA to heme a and altered EPR spectra in mutants close to heme a of cytochrome oxidase.

  Biochemistry 20081104

• X-ray absorption spectroscopy of hemes and hemeproteins in solution: multiple scattering analysis.

  Inorganic chemistry 20081103

• A mechanistic and electrochemical study of the interaction between dimethyl sulfide dehydrogenase and its electron transfer partner cytochrome c2.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20081101

• Nitric oxide bioavailability in the microcirculation: insights from mathematical models.

  Microcirculation (New York, N.Y. : 1994) 20081101

• Heme-binding to the nuclear receptor retinoid X receptor alpha (RXRalpha) leads to the inhibition of the transcriptional activity.

  Gene 20081101

• Biochemical and spectroscopic characterization of the membrane-bound nitrate reductase from Marinobacter hydrocarbonoclasticus 617.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20081101

• Characterization of Bacillus anthracis iron-regulated surface determinant (Isd) proteins containing NEAT domains.

  Molecular microbiology 20081101

• Synthesis and anti-inflammatory activity of chalcones and related Mannich bases.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20081101

• A predictive model of the oxygen and heme regulatory network in yeast.

  PLoS computational biology 20081101

• Interaction of fatty acid with myoglobin.

  FEBS letters 20081029

• Structural basis for the heterotropic and homotropic interactions of invertebrate giant hemoglobin.

  Biochemistry 20081028

• Heme electron transfer in peroxidases: the propionate e-pathway.

  The journal of physical chemistry. B 20081023

• Multiple step assembly of the transmembrane cytochrome b6.

  Journal of molecular biology 20081017

• On the mechanism of quinol oxidation at the QP site in the cytochrome bc1 complex: studied using mutants lacking cytochrome bL or bH.

  The Journal of biological chemistry 20081017

• Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase.

  The Biochemical journal 20081015

• Identification of heme uptake genes in the fish pathogen Aeromonas salmonicida subsp. salmonicida.

  Archives of microbiology 20081001

• Differential expression of Bordetella pertussis iron transport system genes during infection.

  Molecular microbiology 20081001

• Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities.

  Antioxidants & redox signaling 20081001

• Re-engineering of CYP2C9 to probe acid-base substrate selectivity.

  Drug metabolism and disposition: the biological fate of chemicals 20081001

• Haem-regulated eIF2alpha kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency.

  British journal of haematology 20081001

• Heme transport and detoxification in nematodes: subproteomics evidence of differential role of glutathione transferases.

  Journal of proteome research 20081001

• Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress.

  American journal of physiology. Heart and circulatory physiology 20081001

• A cytochrome c containing nitrate reductase plays a role in electron transport for denitrification in Thermus thermophilus without involvement of the bc respiratory complex.

  Molecular microbiology 20081001

• Is the bound substrate in nitric oxide synthase protonated or neutral and what is the active oxidant that performs substrate hydroxylation?

  Journal of the American Chemical Society 20081001

• The role of multihaem cytochromes in the respiration of nitrite in Escherichia coli and Fe(III) in Shewanella oneidensis.

  Biochemical Society transactions 20081001

• Experience in the use of Actovegin in the treatment of patients with cognitive disorders in the acute period of stroke.

  Neuroscience and behavioral physiology 20081001

• pH dependence of cyanide binding to the ferric heme domain of the direct oxygen sensor from Escherichia coli and the effect of alkaline denaturation.

  Biochemistry 20080930

• Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).

  The Journal of biological chemistry 20080919

• Assigning vibrational spectra of ferryl-oxo intermediates of cytochrome C oxidase by periodic orbits and molecular dynamics.

  Journal of the American Chemical Society 20080917

• Role of the conserved distal heme asparagine of coral allene oxide synthase (Asn137) and human catalase (Asn148): mutations affect the rate but not the essential chemistry of the enzymatic transformations.

  Archives of biochemistry and biophysics 20080915

• Modulation of metal displacements in a saddle distorted macrocycle: synthesis, structure, and properties of high-spin Fe(III) porphyrins and implications for the hemoproteins.

  Inorganic chemistry 20080915

• C-terminal deletions in the ALAS2 gene lead to gain of function and cause X-linked dominant protoporphyria without anemia or iron overload.

  American journal of human genetics 20080912

• A Soret marker band for four-coordinate ferric heme proteins from absorption spectra of isolated Fe(III)-Heme+ and Fe(III)-Heme+(His) ions in vacuo.

  Journal of the American Chemical Society 20080910

• Dynamical characterization of the heme NO oxygen binding (HNOX) domain. Insight into soluble guanylate cyclase allosteric transition.

  Biochemistry 20080909

• Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on heme oxygenase-1, biliverdin IXalpha reductase and delta-aminolevulinic acid synthetase 1 in rats with wild-type or variant AH receptor.

  Toxicology 20080904

• Ibuprofen induces an allosteric conformational transition in the heme complex of human serum albumin with significant effects on heme ligation.

  Journal of the American Chemical Society 20080903

• The Rieske/cytochrome b complex of Heliobacteria.

  Biochimica et biophysica acta 20080901

• His92 and His110 selectively affect different heme centers of adrenal cytochrome b(561).

  Biochimica et biophysica acta 20080901

• Acceptor side effects on the electron transfer at cryogenic temperatures in intact photosystem II.

  Biochimica et biophysica acta 20080901

• Down-regulation of the carcinogen-metabolizing enzyme cytochrome P450 1a1 by vanadium.

  Drug metabolism and disposition: the biological fate of chemicals 20080901

• Intraspecific variation in expression of candidate genes for osmoregulation, heme biosynthesis and stress resistance suggests local adaptation in European flounder (Platichthys flesus).

  Heredity 20080901

• A Porphyromonas gingivalis tyrosine phosphatase is a multifunctional regulator of virulence attributes.

  Molecular microbiology 20080901

• In silico description of differential enantioselectivity in methoxychlor O-demethylation by CYP2C enzymes.

  Biochimica et biophysica acta 20080901

• Direct and mediated electron transfer between intact succinate:quinone oxidoreductase from Bacillus subtilis and a surface modified gold electrode reveals redox state-dependent conformational changes.

  Biochimica et biophysica acta 20080901

• The heme precursor delta-aminolevulinate blocks peripheral myelin formation.

  Journal of neurochemistry 20080901

• Evaluation of the (haem)Fe--Nepsilon(2)(HisF8) bond distances from haemoglobin structures deposited in the Protein Data Bank.

  Acta crystallographica. Section D, Biological crystallography 20080901

• Acute depletion of heme by succinylacetone alters vascular responses but does not induce hypertension.

  Canadian journal of physiology and pharmacology 20080901

• Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations.

  Bioscience, biotechnology, and biochemistry 20080901

• Metal ion substrate inhibition of ferrochelatase.

  The Journal of biological chemistry 20080829

• Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.

  Journal of medicinal chemistry 20080828

• Arg97 at the heme-distal side of the isolated heme-bound PAS domain of a heme-based oxygen sensor from Escherichia coli (Ec DOS) plays critical roles in autoxidation and binding to gases, particularly O2.

  Biochemistry 20080826

• Variants of the tetrahaem cytochrome c quinol dehydrogenase NrfH characterize the menaquinol-binding site, the haem c-binding motifs and the transmembrane segment.

  The Biochemical journal 20080815

• A sample extraction and chromatographic strategy for increasing LC/MS detection coverage of the erythrocyte metabolome.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080815

• BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite.

  The Journal of biological chemistry 20080815

• Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin.

  Bioorganic & medicinal chemistry 20080815

• SoxAX cytochromes, a new type of heme copper protein involved in bacterial energy generation from sulfur compounds.

  The Journal of biological chemistry 20080808

• Functional characterization of the Shigella dysenteriae heme ABC transporter.

  Biochemistry 20080805

• Assignment of the ferriheme resonances of high- and low-spin forms of the symmetrical hemin-reconstituted nitrophorins 1-4 by 1H and 13C NMR spectroscopy: the dynamics of heme ruffling deformations.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080801

• Solution 1H NMR study of the active site structure for the double mutant H64Q/V68F cyanide complex from mouse neuroglobin.

  Biophysical chemistry 20080801

• Electrochemical interrogations of the Mtr cytochromes from Shewanella: opening a potential window.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080801

• Effects of amino acids on malarial heme crystallization.

  Biological & pharmaceutical bulletin 20080801

• The lipocalin alpha1-microglobulin protects erythroid K562 cells against oxidative damage induced by heme and reactive oxygen species.

  Free radical research 20080801

• Low-frequency mode activity of heme: femtosecond coherence spectroscopy of iron porphine halides and nitrophorin.

  Journal of the American Chemical Society 20080730

• Glutamate 107 in subunit I of cytochrome bd from Escherichia coli is part of a transmembrane intraprotein pathway conducting protons from the cytoplasm to the heme b595/heme d active site.

  Biochemistry 20080729

• Allostery in recombinant soluble guanylyl cyclase from Manduca sexta.

  The Journal of biological chemistry 20080725

• Lead poisoning from the beauty case: neurologic manifestations in an elderly woman.

  Neurology 20080722

• Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone.

  Archives of biochemistry and biophysics 20080715

• Isoporphyrin intermediate in heme oxygenase catalysis. Oxidation of alpha-meso-phenylheme.

  The Journal of biological chemistry 20080711

• Regulation of eNOS-derived superoxide by endogenous methylarginines.

  Biochemistry 20080708

• Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium.

  Inorganic chemistry 20080707

• Roles of Arg-97 and Phe-113 in regulation of distal ligand binding to heme in the sensor domain of Ec DOS protein. Resonance Raman and mutation study.

  The Journal of biological chemistry 20080704

• Theoretical insight into the hydroxylamine oxidoreductase mechanism.

  Journal of inorganic biochemistry 20080701

• An X-ray diffraction and X-ray absorption spectroscopy joint study of neuroglobin.

  Archives of biochemistry and biophysics 20080701

• Ferric species of the giant extracellular hemoglobin of Glossoscolex paulistus as function of pH: an EPR study on the irreversibility of the heme transitions.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20080701

• Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.

  The Journal of biological chemistry 20080620

• Structure of the dissimilatory sulfite reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus.

  Journal of molecular biology 20080620

• Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.

  Nature 20080619

• Probing the bottom of a folding funnel using conformationally gated electron transfer reactions.

  Journal of the American Chemical Society 20080618

• Theoretical and experimental evaluation of a CYP106A2 low homology model and production of mutants with changed activity and selectivity of hydroxylation.

  Chembiochem : a European journal of chemical biology 20080616

• The biochemistry of heme biosynthesis.

  Archives of biochemistry and biophysics 20080615

• The effect of haem biosynthesis inhibitors and inducers on intestinal iron absorption and liver haem biosynthetic enzyme activities.

  Toxicology and applied pharmacology 20080615

• Tissue-specific expression of ALA synthase-1 and heme oxygenase-1 and their expression in livers of rats chronically exposed to ethanol.

  FEBS letters 20080611

• On the functional role of a water molecule in clade 3 catalases: a proposal for the mechanism by which NADPH prevents the formation of compound II.

  Journal of the American Chemical Society 20080611

• Heme-binding characteristics of the isolated PAS-A domain of mouse Per2, a transcriptional regulatory factor associated with circadian rhythms.

  Biochemistry 20080610

• An investigation of hemopexin redox properties by spectroelectrochemistry: biological relevance for heme uptake.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20080601

• Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function.

  American journal of respiratory cell and molecular biology 20080601

• The mechanism of antimalarial action of the ruthenium(II)-chloroquine complex [RuCl(2)(CQ)] (2).

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080601

• Heme content of recombinant catalase from Psychrobacter sp. T-3 altered by host Escherichia coli cell growth conditions.

  Protein expression and purification 20080601

• Comparing the electronic properties and docking calculations of heme derivatives on CYP2B4.

  Journal of molecular modeling 20080601

• Characterization of heme-coordinating histidyl residues of an engineered six-coordinated myoglobin mutant based on the reactivity with diethylpyrocarbonate, mass spectrometry, and electron paramagnetic resonance spectroscopy.

  Journal of bioscience and bioengineering 20080601

• Membrane tetraheme cytochrome c(m552) of the ammonia-oxidizing nitrosomonas europaea: a ubiquinone reductase.

  Biochemistry 20080528

• Ultrafast heme-residue bond formation in six-coordinate heme proteins: implications for functional ligand exchange.

  Biochemistry 20080527

• The pH dependence of heme pocket hydration and ligand rebinding kinetics in photodissociated carbonmonoxymyoglobin.

  The Journal of biological chemistry 20080516

• Chemical and steady-state kinetic analyses of a heterologously expressed heme dependent chlorite dismutase.

  Biochemistry 20080513

• Relative axial ligand orientation in bis(imidazole)iron(II) porphyrinates: are 'picket fence' derivatives different?

  Inorganic chemistry 20080505

• Selenolate complexes of CYP101 and the heme-bound hHO-1/H25A proximal cavity mutant.

  Inorganic chemistry 20080505

• Isolated cytochrome c oxidase deficiency in G93A SOD1 mice overexpressing CCS protein.

  The Journal of biological chemistry 20080502

• Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium.

  The British journal of nutrition 20080501

• Exploring the molecular basis of heme coordination in human neuroglobin.

  Proteins 20080501

• Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex.

  Molecular pharmacology 20080501

• How does reorganization energy change upon protein unfolding? Monitoring the structural perturbations in the heme cavity of cytochrome c.

  Biophysical chemistry 20080501

• Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae.

  Eukaryotic cell 20080501

• Interaction between artemisinin and heme. A Density Functional Theory study of structures and interaction energies.

  Bioorganic & medicinal chemistry 20080501

• Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems?

  The FEBS journal 20080501

• Hemin arginate-induced heme oxygenase 1 expression improves liver microcirculation and mediates an anti-inflammatory cytokine response after hemorrhagic shock.

  Shock (Augusta, Ga.) 20080501

• Bis-histidine-coordinated hemes in four-helix bundles: how the geometry of the bundle controls the axial imidazole plane orientations in transmembrane cytochromes of mitochondrial complexes II and III and related proteins.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080501

• Polyvalent display of heme on hepatitis B virus capsid protein through coordination to hexahistidine tags.

  Chemistry & biology 20080501

• Effector-induced structural fluctuation regulates the ligand affinity of an allosteric protein: binding of inositol hexaphosphate has distinct dynamic consequences for the T and R states of hemoglobin.

  Biochemistry 20080429

• Novel fluorescence method for real-time monitoring of nitric oxide dynamics in nanoscale concentration.

  Journal of biochemical and biophysical methods 20080424

• Density functional theory calculations of the lowest energy quintet and triplet states of model hemes: role of functional, basis set, and zero-point energy corrections.

  The journal of physical chemistry. A 20080424

• Modulation of redox potential and alteration in reactivity via the peroxide shunt pathway by mutation of cytochrome P450 around the proximal heme ligand.

  Biochemistry 20080422

• ATP-driven reduction by dark-operative protochlorophyllide oxidoreductase from Chlorobium tepidum mechanistically resembles nitrogenase catalysis.

  The Journal of biological chemistry 20080418

• Coherence spectroscopy investigations of the low-frequency vibrations of heme: effects of protein-specific perturbations.

  Journal of the American Chemical Society 20080416

• Structures and solution properties of two novel periplasmic sensor domains with c-type heme from chemotaxis proteins of Geobacter sulfurreducens: implications for signal transduction.

  Journal of molecular biology 20080411

• Modeling the active-site structure of the cbb3-type oxidase from Rhodobacter sphaeroides.

  Biochemistry 20080408

• Structure and ligand selection of hemoglobin II from Lucina pectinata.

  The Journal of biological chemistry 20080404

• Alkyl peroxides reveal the ring opening mechanism of verdoheme catalyzed by heme oxygenase.

  Journal of the American Chemical Society 20080402

• Leishmania spp.: delta-aminolevulinate-inducible neogenesis of porphyria by genetic complementation of incomplete heme biosynthesis pathway.

  Experimental parasitology 20080401

• BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase.

  Molecular pharmacology 20080401

• Probing the presence of the ligand-binding haem in cellular nitric oxide receptors.

  British journal of pharmacology 20080401

• Phospholipid membranes affect tertiary structure of the soluble cytochrome b5 heme-binding domain.

  Biochimica et biophysica acta 20080401

• Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase.

  Analytical chemistry 20080401

• Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Porphobilinogen deaminase.

  Analytical chemistry 20080401

• HDP-a novel heme detoxification protein from the malaria parasite.

  PLoS pathogens 20080401

• Cellular and mitochondrial remodeling upon defects in iron-sulfur protein biogenesis.

  The Journal of biological chemistry 20080328

• Role of locus coeruleus heme oxygenase-carbon monoxide-cGMP pathway during hypothermic response to restraint.

  Brain research bulletin 20080328

• Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel.

  Biochemistry 20080325

• Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes.

  Biochemistry 20080325

• A density functional theory investigation on the mechanism of the second half-reaction of nitric oxide synthase.

  Journal of the American Chemical Society 20080319

• A comparative density-functional study of the reaction mechanism of the O2-dependent coproporphyrinogen III oxidase.

  Bioorganic & medicinal chemistry 20080315

• Cytotoxic effects of metal protoporphyrins in glioblastoma cells: roles of albumin, reactive oxygen species, and heme oxygenase-1.

  Toxicology letters 20080315

• Protein conformation changes of HemAT-Bs upon ligand binding probed by ultraviolet resonance Raman spectroscopy.

  The Journal of biological chemistry 20080314

• Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies.

  Journal of medicinal chemistry 20080313

• Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase.

  Biochemistry 20080311

• The tuberculosis prodrug isoniazid bound to activating peroxidases.

  The Journal of biological chemistry 20080307

• Hydrogen atom transfer reactions of iron-porphyrin-imidazole complexes as models for histidine-ligated heme reactivity.

  Journal of the American Chemical Society 20080305

• Macrophages function as a ferritin iron source for cultured human erythroid precursors.

  Journal of cellular biochemistry 20080301

• Heme oxygenase-1 induction depletes heme and attenuates pulmonary artery relaxation and guanylate cyclase activation by nitric oxide.

  American journal of physiology. Heart and circulatory physiology 20080301

• Heme-heme communication during the alkaline-induced structural transition in cytochrome c oxidase.

  Journal of inorganic biochemistry 20080301

• Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism.

  Biochimica et biophysica acta 20080301

• Heme binding in the NEAT domains of IsdA and IsdC of Staphylococcus aureus.

  Journal of inorganic biochemistry 20080301

• Expression of the phytochrome operon in Pseudomonas aeruginosa is dependent on the alternative sigma factor RpoS.

  FEMS microbiology letters 20080301

• Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1.

  Biochimica et biophysica acta 20080301

• Mutations in cytochrome b that affect kinetics of the electron transfer reactions at center N in the yeast cytochrome bc1 complex.

  Biochimica et biophysica acta 20080301

• Heme, a plastid-derived regulator of nuclear gene expression in Chlamydomonas.

  The Plant cell 20080301

• Deciphering the structural role of histidine 83 for heme binding in hemophore HasA.

  The Journal of biological chemistry 20080227

• Crystal structure of lactoperoxidase at 2.4 A resolution.

  Journal of molecular biology 20080227

• Assessing and influencing the fractional contribution of erythrocyte-bound 59Fe to individual 59Fe tissue content in murine 59Fe distribution studies.

  Toxicology 20080227

• Protonation of the proximal histidine ligand in heme peroxidases.

  The journal of physical chemistry. B 20080227

• Role of the spinal cord heme oxygenase-carbon monoxide-cGMP pathway in the nociceptive response of rats.

  European journal of pharmacology 20080226

• DFT analysis of axial and equatorial effects on heme-CO vibrational modes: applications to CooA and H-NOX heme sensor proteins.

  Biochemistry 20080226

• Revisiting heme mechanisms. A perspective on the mechanisms of nitric oxide synthase (NOS), Heme oxygenase (HO), and cytochrome P450s (CYP450s).

  Biochemistry 20080226

• Novel heme ligand displacement by CO in the soluble hemophore HasA and its proximal ligand mutants: implications for heme uptake and release.

  Biochemistry 20080219

• Production and separation of manganese peroxidase from heme amended yeast cultures.

  Biotechnology and bioengineering 20080215

• A heme export protein is required for red blood cell differentiation and iron homeostasis.

  Science (New York, N.Y.) 20080208

• Near-IR MCD of the nonheme ferrous active site in naphthalene 1,2-dioxygenase: correlation to crystallography and structural insight into the mechanism of Rieske dioxygenases.

  Journal of the American Chemical Society 20080206

• Protective role of heme oxygenase 1 in the intestinal tissue injury in hemorrhagic shock in rats.

  Shock (Augusta, Ga.) 20080201

• Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080201

• Body iron stores and dietary iron intake in relation to diabetes in adults in North China.

  Diabetes care 20080201

• Catalytic turnover dependent modification of the Pseudomonas aeruginosa heme oxygenase (pa-HO) by 5,6-O-isopropyledine-2-O-allyl-ascorbic acid.

  Journal of inorganic biochemistry 20080201

• Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(omega-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone.

  Bioorganic & medicinal chemistry 20080201

• Spectroscopic study on the communication between a heme a3 propionate, Asp399 and the binuclear center of cytochrome c oxidase from Paracoccus denitrificans.

  Biochimica et biophysica acta 20080201

• Redox-coupled proton pumping in cytochrome c oxidase: further insights from computer simulation.

  Biochimica et biophysica acta 20080201

• Role of heme in the antifungal activity of the azaoxoaporphine alkaloid sampangine.

  Eukaryotic cell 20080201

• Essential role of the AH receptor in the dysfunction of heme metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  Chemical research in toxicology 20080201

• A cysteine residue near the propionate side chain of heme is the radical site in ascorbate peroxidase.

  The FEBS journal 20080201

• Dietary heme injures surface epithelium resulting in hyperproliferation, inhibition of apoptosis and crypt hyperplasia in rat colon.

  Carcinogenesis 20080201

• Iron chelators can protect against oxidative stress through ferryl heme reduction.

  Free radical biology & medicine 20080201

• Tyrosine as a redox-active center in electron transfer to ferryl heme in globins.

  Free radical biology & medicine 20080201

• Plesiomonas shigelloides hugZ encodes an iron-regulated heme binding protein required for heme iron utilization.

  Canadian journal of microbiology 20080201

• Ligand dynamics and early signaling events in the heme domain of the sensor protein Dos from Escherichia coli.

  The Journal of biological chemistry 20080125

• The role of the conserved threonine in P450 BM3 oxygen activation: substrate-determined hydroxylation activity of the Thr268Ala mutant.

  Chembiochem : a European journal of chemical biology 20080125

• Evaluation of the functional role of the heme-6-propionate side chain in cytochrome P450cam.

  Journal of the American Chemical Society 20080116

• Microvascular endothelial cells express a phosphatidylserine receptor: a functionally active receptor for phosphatidylserine-positive erythrocytes.

  Blood 20080115

• Dietary iron and haem iron intake and risk of endometrial cancer: a prospective cohort study.

  British journal of cancer 20080115

• Effect of reversed heme orientation on circular dichroism and cooperative oxygen binding of human adult hemoglobin.

  Biochemistry 20080115

• Implication for using heme methyl hyperfine shifts as indicators of heme seating as related to stereoselectivity in the catabolism of heme by heme oxygenase: in-plane heme versus axial his rotation.

  Biochemistry 20080108

• Broad substrate Cytochrome P450 monooxygenase activity in the cells of Aspergillus terreus MTCC 6324.

  Bioresource technology 20080101

• Dietary animal-derived iron and fat intake and breast cancer risk in the Shanghai Breast Cancer Study.

  Breast cancer research and treatment 20080101

• SFH2 regulates fatty acid synthase activity in the yeast Saccharomyces cerevisiae and is critical to prevent saturated fatty acid accumulation in response to haem and oleic acid depletion.

  The Biochemical journal 20080101

• Active-site structure, binding and redox activity of the heme-thiolate enzyme CYP2D6 immobilized on coated Ag electrodes: a surface-enhanced resonance Raman scattering study.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080101

• Characterization of N-terminal amino group-heme ligation emerging upon guanidine hydrochloric acid induced unfolding of Hydrogenobacter thermophilus ferricytochrome c552.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080101

• Role of Tyr residues on the protein surface of cationic cell-wall-peroxidase (CWPO-C) from poplar: potential oxidation sites for oxidative polymerization of lignin.

  Phytochemistry 20080101

• Noninnocent effect of axial ligand on the heme degradation process: a theoretical approach to hydrolysis pathway of verdoheme to biliverdin.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080101

• Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change.

  The Journal of biological chemistry 20080101

• A structural perspective on mechanism and function of the cytochrome bc (1) complex.

  Results and problems in cell differentiation 20080101

• Probing inducible nitric oxide synthase with a pterin-ruthenium(II) sensitizer wire.

  Angewandte Chemie (International ed. in English) 20080101

• A two-state reactivity rationale for counterintuitive axial ligand effects on the C-H activation reactivity of nonheme FeIV=O oxidants.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• The surface protein Shr of Streptococcus pyogenes binds heme and transfers it to the streptococcal heme-binding protein Shp.

  BMC microbiology 20080101

• Heme rescues a two-component system Leptospira biflexa mutant.

  BMC microbiology 20080101

• Structural studies on flavohemoglobins.

  Methods in enzymology 20080101

• Assay and characterization of the NO dioxygenase activity of flavohemoglobins.

  Methods in enzymology 20080101

• Mapping heme-ligand tunnels in group I truncated(2/2) hemoglobins.

  Methods in enzymology 20080101

• Measurement of distal histidine coordination equilibrium and kinetics in hexacoordinate hemoglobins.

  Methods in enzymology 20080101

• Cerebroprotective functions of HO-2.

  Current pharmaceutical design 20080101

• Bioavailability of heme iron in biscuit filling using piglets as an animal model for humans.

  International journal of biological sciences 20080101

• The phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions.

  BMC evolutionary biology 20080101

• Structural propensities in the heme binding region of apocytochrome b5. I. Free peptides.

  Biopolymers 20080101

• Structural propensities in the heme binding region of apocytochrome b5. II. Heme conjugates.

  Biopolymers 20080101

• High catalytic activities of artificial peroxidases based on supramolecular hydrogels that contain heme models.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• NO dioxygenase activity in hemoglobins is ubiquitous in vitro, but limited by reduction in vivo.

  PloS one 20080101

• Molecular interactions of the neuronal GPI-anchored lipocalin Lazarillo.

  Journal of molecular recognition : JMR 20080101

• Genetic and biochemical studies in Argentinean patients with variegate porphyria.

  BMC medical genetics 20080101

• Functional role of Ile264 in CYP2C8: mutations affect haem incorporation and catalytic activity.

  Drug metabolism and pharmacokinetics 20080101

• Relation of iron and red meat intake to blood pressure: cross sectional epidemiological study.

  BMJ (Clinical research ed.) 20080101

• Mechanism and role of covalent heme binding in the CYP4 family of P450 enzymes and the mammalian peroxidases.

  Drug metabolism reviews 20080101

• Proton- and reductant-assisted dioxygen activation by a nonheme iron(II) complex to form an oxoiron(IV) intermediate.

  Angewandte Chemie (International ed. in English) 20080101

• Adenine nucleotide translocator transports haem precursors into mitochondria.

  PloS one 20080101

• [The mechanism of oxymyoglobin oxidation by copper ions and complexes: myoglobins carboxymethylated and carboxyamidated at histidine residues].

  Biofizika 20080101

• [Influence of cattle cord blood fraction below 5 kD on biochemical parameters of blood in experimental chronic stomach ulcer in rats].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20080101

• [Heme oxygenase activity in the tissues of the vessels and heart of rats under co-administration of NO-synthase inhibitor and hemin chloride].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20080101

• Functional identification of HugZ, a heme oxygenase from Helicobacter pylori.

  BMC microbiology 20080101

• [Phenotypic properties of Sulfobacillus thermotolerans: comparative aspects].

  Mikrobiologiia 20080101

• [Metabolic effects of mexidol in complex treatment of chronic brain ischemia].

  Eksperimental'naia i klinicheskaia farmakologiia 20080101

• Heme oxygenase (HO-1) is involved in the negative regulation of contact sensitivity reaction.

  Pharmacological reports : PR 20080101

• [Bioregulating therapy and life quality in aged patients with hypertonic angioretinopathy].

  Advances in gerontology = Uspekhi gerontologii 20080101

• Characterization of a globin-coupled oxygen sensor with a gene-regulating function.

  The Journal of biological chemistry 20071228

• Characterization of temperature-dependent iron-imidazole vibrational modes in far infrared.

  The journal of physical chemistry. B 20071227

• Heme synthase (ferrochelatase) catalyzes the removal of iron from heme and demetalation of metalloporphyrins.

  Biochemistry 20071225

• Dioxygen activation at non-heme diiron centers: oxidation of a proximal residue in the I100W variant of toluene/o-xylene monooxygenase hydroxylase.

  Biochemistry 20071225

• Magnetic circular dichroism evidence for a weakly coupled heme-radical pair at the active site of cytochrome cd1, a nitrite reductase.

  Inorganic chemistry 20071224

• Identification of two heme-binding sites in the cytoplasmic heme-trafficking protein PhuS from Pseudomonas aeruginosa and their relevance to function.

  Biochemistry 20071218

• Versatile regulation of neuronal nitric oxide synthase by specific regions of its C-terminal tail.

  Biochemistry 20071218

• Measurement of the heme affinity for yeast dap1p, and its importance in cellular function.

  Biochemistry 20071218

• Tuning the formation of a covalent haem-protein link by selection of reductive or oxidative conditions as exemplified by ascorbate peroxidase.

  The Biochemical journal 20071215

• Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein.

  The Biochemical journal 20071215

• Low frequency spectral density of ferrous heme: perturbations induced by axial ligation and protein insertion.

  Biophysical journal 20071215

• Response of lead-induced oxidative stress and alterations in biogenic amines in different rat brain regions to combined administration of DMSA and MiADMSA.

  Chemico-biological interactions 20071215

• DyP, a unique dye-decolorizing peroxidase, represents a novel heme peroxidase family: ASP171 replaces the distal histidine of classical peroxidases.

  The Journal of biological chemistry 20071214

• Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.

  The Journal of biological chemistry 20071214

• Circadian rhythms. Daily watch on metabolism.

  Science (New York, N.Y.) 20071214

• Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.

  Science (New York, N.Y.) 20071214

• Alteration of P450 distal pocket solvent leads to impaired proton delivery and changes in heme geometry.

  Biochemistry 20071211

• The hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells.

  Biochemistry 20071211

• Unraveling the reactive species of a functional non-heme iron monooxygenase model using stopped-flow UV-vis spectroscopy.

  Inorganic chemistry 20071210

• Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide.

  The Journal of biological chemistry 20071207

• Development of a bacterial system for high yield expression of fully functional adrenal cytochrome b561.

  Protein expression and purification 20071201

• Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor.

  The Journal of pharmacology and experimental therapeutics 20071201

• Therapeutic applications of bilirubin and biliverdin in transplantation.

  Antioxidants & redox signaling 20071201

• Involvement of 101F6, a homologue of cytochrome b561, in the reduction of ferric ions.

  Journal of biochemistry 20071201

• Regulation of human liver delta-aminolevulinic acid synthase by bile acids.

  Hepatology (Baltimore, Md.) 20071201

• The Saccharomyces cerevisiae succinate dehydrogenase does not require heme for ubiquinone reduction.

  Biochimica et biophysica acta 20071201

• Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta.

  Nature structural & molecular biology 20071201

• Targeting parasite-mediated host hemoglobin degradation in malaria.

  IDrugs : the investigational drugs journal 20071201

• Helicoverpa zea CYP6B8 and CYP321A1: different molecular solutions to the problem of metabolizing plant toxins and insecticides.

  Protein engineering, design & selection : PEDS 20071201

• Lead hepatotoxicity & potential health effects.

  The Indian journal of medical research 20071201

• Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, beta-globin, and NADP(H) quinone (oxido) reductase1.

  The Journal of biological chemistry 20071123

• Nitrite controls the release of nitric oxide in Pseudomonas aeruginosa cd1 nitrite reductase.

  Biochemical and biophysical research communications 20071123

• The reactivity of heme in biological systems: autocatalytic formation of both tyrosine-heme and tryptophan-heme covalent links in a single protein architecture.

  Biochemistry 20071120

• Investigation of the redox centres of periplasmic selenate reductase from Thauera selenatis by EPR spectroscopy.

  The Biochemical journal 20071115

• Ferrous human cystathionine beta-synthase loses activity during enzyme assay due to a ligand switch process.

  Biochemistry 20071113

• Heme binding properties of Staphylococcus aureus IsdE.

  Biochemistry 20071106

• Studies on direct electron transfer and biocatalytic properties of hemoglobin in polyacrylonitrile matrix.

  Bioelectrochemistry (Amsterdam, Netherlands) 20071101

• Interaction of iron(II)-heme and artemisinin with a peptide mimic of Plasmodium falciparum HRP-II.

  Journal of inorganic biochemistry 20071101

• Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif.

  Proteins 20071101

• Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA.

  Proteins 20071101

• Theoretical investigation on the oxidative chlorination performed by a biomimetic non-heme iron catalyst.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20071101

• Histidine cycle mechanism for the concerted proton/electron transfer from ascorbate to the cytosolic haem b centre of cytochrome b561: a unique machinery for the biological transmembrane electron transfer.

  Journal of biochemistry 20071101

• Peroxynitrite inactivation of human cytochrome P450s 2B6 and 2E1: heme modification and site-specific nitrotyrosine formation.

  Chemical research in toxicology 20071101

• Ligand migration in nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana.

  The journal of physical chemistry. B 20071101

• The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation.

  The Journal of clinical investigation 20071101

• Intermittent unexplained abdominal pain: is it porphyria?

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20071101

• [Favorable outcome of acute porphyric neuropathy after treatment with heme arginate].

  Revue neurologique 20071101

• Non-native heme-histidine ligation promotes microsecond time scale secondary structure formation in reduced horse heart cytochrome c.

  Biochemistry 20071030

• The second enzyme in pyrrolnitrin biosynthetic pathway is related to the heme-dependent dioxygenase superfamily.

  Biochemistry 20071030

• Bis-methionine ligation to heme iron in the streptococcal cell surface protein Shp facilitates rapid hemin transfer to HtsA of the HtsABC transporter.

  The Journal of biological chemistry 20071026

• Kinetic resolution of a tryptophan-radical intermediate in the reaction cycle of Paracoccus denitrificans cytochrome c oxidase.

  The Journal of biological chemistry 20071026

• Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency.

  Journal of molecular biology 20071026

• Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release.

  Biochemistry 20071023

• Heme attachment motif mobility tunes cytochrome c redox potential.

  Biochemistry 20071023

• Mechanism of formation of the ester linkage between heme and Glu310 of CYP4B1: 18O protein labeling studies.

  Biochemistry 20071016

• The roles of Tyr(CD1) and Trp(G8) in Mycobacterium tuberculosis truncated hemoglobin O in ligand binding and on the heme distal site architecture.

  Biochemistry 20071016

• Effect of strain in the proximal ligand on the binding of nitric oxide and carbon monoxide to chelated protoheme complexes.

  Inorganic chemistry 20071015

• Myeloperoxidase-catalyzed taurine chlorination: initial versus equilibrium rate.

  Archives of biochemistry and biophysics 20071015

• The DOMON domains are involved in heme and sugar recognition.

  Bioinformatics (Oxford, England) 20071015

• Human tryptophanyl-tRNA synthetase binds with heme to enhance its aminoacylation activity.

  Biochemistry 20071009

• Cytochrome bd from Azotobacter vinelandii: evidence for high-affinity oxygen binding.

  Biochemistry 20071002

• Electrochemical reduction of ferrous alpha-verdoheme in complex with heme oxygenase-1.

  Journal of inorganic biochemistry 20071001

• Heme oxygenase-1 protects against radiocontrast-induced acute kidney injury by regulating anti-apoptotic proteins.

  Kidney international 20071001

• Haeme-regulated degradation of delta-aminolevulinate synthase 1 in rat liver mitochondria.

  Journal of biochemistry 20071001

• X-ray crystal structural analysis of the binding site in the ferric and oxyferrous forms of the recombinant heme dehaloperoxidase cloned from Amphitrite ornata.

  Acta crystallographica. Section D, Biological crystallography 20071001

• Tyrosinase-generated quinones induce covalent modification, unfolding, and aggregation of human holo-myoglobin.

  Biomacromolecules 20071001

• Heme regulates exocrine peptidase precursor genes in zebrafish.

  Experimental biology and medicine (Maywood, N.J.) 20071001

• [Gene defects identified in porphyrias and their participation in onset of this disease].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20071001

• Site-directed mutagenesis of five conserved residues of subunit i of the cytochrome cbb3 oxidase in Rhodobacter capsulatus.

  Journal of biochemistry and molecular biology 20070930

• Heme coordination by Staphylococcus aureus IsdE.

  The Journal of biological chemistry 20070928

• Theoretical DFT study of fragmentation and association of heme and hemin.

  The journal of physical chemistry. A 20070927

• The hydrogen-bonding network in heme oxygenase also functions as a modulator of enzyme dynamics: chaotic motions upon disrupting the H-bond network in heme oxygenase from Pseudomonas aeruginosa.

  Journal of the American Chemical Society 20070926

• Activation of the cytochrome cd1 nitrite reductase from Paracoccus pantotrophus. Reaction of oxidized enzyme with substrate drives a ligand switch at heme c.

  The Journal of biological chemistry 20070921

• Impact of two novel mutations on the structure and function of human myeloperoxidase.

  The Journal of biological chemistry 20070921

• Alkaline conformational transition and gated electron transfer with a Lys 79 --> his variant of iso-1-cytochrome c.

  Biochemistry 20070918

• A comparative study on axial coordination and ligand binding in ferric mini myoglobin and horse heart myoglobin.

  Biophysical journal 20070915

• Dietary antioxidants as inhibitors of the heme-induced peroxidation of linoleic acid: mechanism of action and synergism.

  Free radical biology & medicine 20070915

• Myeloperoxidase is a key regulator of oxidative stress mediated apoptosis in myeloid leukemic cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070915

• [Heme-iron in the human body].

  Orvosi hetilap 20070909

• Signaling and DNA-binding activities of the Staphylococcus aureus HssR-HssS two-component system required for heme sensing.

  The Journal of biological chemistry 20070907

• Two conserved non-canonical histidines are essential for activity of the cbb (3)-type oxidase in Rhodobacter capsulatus: non-canonical histidines are essential for cbb (3)-type oxidase activity in R. capsulatus.

  Molecular biology reports 20070901

• Solution conformation of the His-47 to Ala-47 mutant of Pseudomonas stutzeri ZoBell ferrocytochrome c-551.

  Biophysical journal 20070901

• Redox reactivity of the heme Fe3+/Fe 2+ couple in native myoglobins and mutants with peroxidase-like activity.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070901

• Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhaemoglobin.

  Archives of biochemistry and biophysics 20070901

• Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.

  Bioorganic & medicinal chemistry letters 20070901

• Interaction of heme and heme-hemopexin with an extracellular oxidant system used to measure cell growth-associated plasma membrane electron transport.

  Biochimica et biophysica acta 20070901

• Dynamics of the glutamic acid 242 side chain in cytochrome c oxidase.

  Biochimica et biophysica acta 20070901

• Modulation of heme and myristate binding to human serum albumin by anti-HIV drugs. An optical and NMR spectroscopic study.

  The FEBS journal 20070901

• A critical role for the co-repressor N-CoR in erythroid differentiation and heme synthesis.

  Cell research 20070901

• Heme as a magnificent molecule with multiple missions: heme determines its own fate and governs cellular homeostasis.

  The Tohoku journal of experimental medicine 20070901

• [Hematocornea].

  Klinische Monatsblatter fur Augenheilkunde 20070901

• Electronic structure and FeNO conformation of nonheme iron-thiolate-NO complexes: an experimental and DFT study.

  Journal of the American Chemical Society 20070829

• Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.

  The Journal of biological chemistry 20070824

• Structure and ligand binding properties of myoglobins reconstituted with monodepropionated heme: functional role of each heme propionate side chain.

  Biochemistry 20070821

• Sequence composition effects on denatured state loop formation in iso-1-cytochrome c variants: polyalanine versus polyglycine inserts.

  Journal of molecular biology 20070817

• Detection of heme oxygenase activity in a library of four-helix bundle proteins: towards the de novo synthesis of functional heme proteins.

  Journal of molecular biology 20070817

• Transient ligand docking sites in Cerebratulus lacteus mini-hemoglobin.

  Gene 20070815

• Neuroglobin and cytoglobin as potential enzyme or substrate.

  Gene 20070815

• Different roles of protein dynamics and ligand migration in non-symbiotic hemoglobins AHb1 and AHb2 from Arabidopsis thaliana.

  Gene 20070815

• Crystal structures of two hemoglobin components from the midge larva Propsilocerus akamusi (Orthocladiinae, Diptera).

  Gene 20070815

• Intramolecular electron transfer in the dihaem cytochrome c peroxidase of Pseudomonas aeruginosa.

  Chembiochem : a European journal of chemical biology 20070813

• Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070808

• Tricarballylate catabolism in Salmonella enterica. The TcuB protein uses 4Fe-4S clusters and heme to transfer electrons from FADH2 in the tricarballylate dehydrogenase (TcuA) enzyme to electron acceptors in the cell membrane.

  Biochemistry 20070807

• An octaheme c-type cytochrome from Shewanella oneidensis can reduce nitrite and hydroxylamine.

  FEBS letters 20070807

• Reactivity studies on Fe(III)-(O2(2-))-Cu(II) compounds: influence of the ligand architecture and copper ligand denticity.

  Inorganic chemistry 20070806

• Oleamide synthesizing activity from rat kidney: identification as cytochrome c.

  The Journal of biological chemistry 20070803

• In vitro synthesis of oleoylglycine by cytochrome c points to a novel pathway for the production of lipid signaling molecules.

  The Journal of biological chemistry 20070803

• Asymmetric binding of stigmatellin to the dimeric Paracoccus denitrificans bc1 complex: evidence for anti-cooperative ubiquinol oxidation and communication between center P ubiquinol oxidation sites.

  The Journal of biological chemistry 20070803

• Cloning and characterization of a novel periplasmic heme-transport protein from the human pathogen Pseudomonas aeruginosa.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070801

• A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6.

  Drug metabolism and disposition: the biological fate of chemicals 20070801

• Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.

  The Journal of pharmacology and experimental therapeutics 20070801

• Activation of the cytochrome c peroxidase of Pseudomonas aeruginosa. The role of a heme-linked protein loop: a mutagenesis study.

  Journal of inorganic biochemistry 20070801

• HEMA RNAi silencing reveals a control mechanism of ALA biosynthesis on Mg chelatase and Fe chelatase.

  Plant molecular biology 20070801

• Identification of Cys385 in the isolated kinase insertion domain of heme-regulated eIF2 alpha kinase (HRI) as the heme axial ligand by site-directed mutagenesis and spectral characterization.

  Journal of inorganic biochemistry 20070801

• DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis.

  Protein science : a publication of the Protein Society 20070801

• Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium.

  Toxicology letters 20070801

• Modulation of heme redox potential in the cytochrome c6 family.

  Journal of the American Chemical Society 20070801

• Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation.

  Neurology 20070731

• What is the active species of cytochrome P450 during camphor hydroxylation? QM/MM studies of different electronic states of compound I and of reduced and oxidized iron-oxo intermediates.

  Journal of the American Chemical Society 20070725

• Axial ligation and stoichiometry of heme centers in adrenal cytochrome b561.

  Biochemistry 20070724

• Crystal structure of the 16 heme cytochrome from Desulfovibrio gigas: a glycosylated protein in a sulphate-reducing bacterium.

  Journal of molecular biology 20070720

• Critical role of the heme axial ligand, Met95, in locking catalysis of the phosphodiesterase from Escherichia coli (Ec DOS) toward Cyclic diGMP.

  The Journal of biological chemistry 20070720

• Substrate-specific interactions with the heme-bound oxygen molecule of nitric-oxide synthase.

  The Journal of biological chemistry 20070720

• The crystal structure of cytochrome P460 of Nitrosomonas europaea reveals a novel cytochrome fold and heme-protein cross-link.

  Biochemistry 20070717

• PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme.

  Biochemistry 20070717

• Molecular dynamics simulation of deoxy and carboxy murine neuroglobin in water.

  Biophysical journal 20070715

• Evidence for oxygen as the master regulator of the responsiveness of soluble guanylate cyclase and cytochrome c oxidase to nitric oxide.

  The Biochemical journal 20070715

• Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress.

  The Journal of biological chemistry 20070713

• Conformational dynamics of the cytochrome P450 BM3/N-palmitoylglycine complex: the proposed 'proximal-distal' transition probed by temperature-jump spectroscopy.

  The journal of physical chemistry. B 20070712

• The unusal redox centers of SoxXA, a novel c-type heme-enzyme essential for chemotrophic sulfur-oxidation of Paracoccus pantotrophus.

  Biochemistry 20070703

• Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket.

  Biochemistry 20070703

• A cohort study of dietary iron and heme iron intake and risk of colorectal cancer in women.

  British journal of cancer 20070702

• A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.

  Experimental parasitology 20070701

• CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysis.

  Drug metabolism and disposition: the biological fate of chemicals 20070701

• The contribution of heme propionate groups to the conformational dynamics associated with CO photodissociation from horse heart myoglobin.

  Journal of inorganic biochemistry 20070701

• Interdiction of the diabetic state in NOD mice by sustained induction of heme oxygenase: possible role of carbon monoxide and bilirubin.

  Antioxidants & redox signaling 20070701

• Replacement of non-heme Fe(II) with Cu(II) in the alpha-ketoglutarate dependent DNA repair enzyme AlkB: spectroscopic characterization of the active site.

  Journal of inorganic biochemistry 20070701

• Respiration of metal (hydr)oxides by Shewanella and Geobacter: a key role for multihaem c-type cytochromes.

  Molecular microbiology 20070701

• A kinetic approach to the dependence of dissimilatory metal reduction by Shewanella oneidensis MR-1 on the outer membrane cytochromes c OmcA and OmcB.

  The FEBS journal 20070701

• Structure of the cytochrome b6f complex: quinone analogue inhibitors as ligands of heme cn.

  Journal of molecular biology 20070629

• Simulation of heme using DFT + U: a step toward accurate spin-state energetics.

  The journal of physical chemistry. B 20070628

• Probing heme coordination states of inducible nitric oxide synthase with a ReI(imidazole-alkyl-nitroarginine) sensitizer-wire.

  The journal of physical chemistry. B 20070621

• A mass spectrometric investigation of native and oxidatively inactivated chloroperoxidase.

  Chembiochem : a European journal of chemical biology 20070618

• Static normal coordinate deformations of the heme group in mutants of ferrocytochrome c from Saccharomyces cerevisiae probed by resonance Raman spectroscopy.

  The journal of physical chemistry. B 20070614

• Induction of 5-aminolevulinate synthase by activators of steroid biosynthesis.

  Life sciences 20070613

• Effect of the N-terminus on heme cavity structure, ligand equilibrium, rate constants, and reduction potentials of nitrophorin 2 from Rhodnius prolixus.

  Biochemistry 20070612

• Biglutaminyl-biliverdin IX alpha as a heme degradation product in the dengue fever insect-vector Aedes aegypti.

  Biochemistry 20070612

• Structure of the human lung cytochrome P450 2A13.

  The Journal of biological chemistry 20070608

• Disruption of the aspartate to heme ester linkage in human myeloperoxidase: impact on ligand binding, redox chemistry, and interconversion of redox intermediates.

  The Journal of biological chemistry 20070608

• A new dinuclear heme-copper complex derived from functionalized protoporphyrin IX.

  Dalton transactions (Cambridge, England : 2003) 20070607

• Iron acquisition mechanisms of the Burkholderia cepacia complex.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20070601

• Bordetella iron transport and virulence.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20070601

• Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070601

• Air-stable, heme-like water-soluble iron(II) porphyrin: in situ preparation and characterization.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070601

• The role of transporters in cellular heme and porphyrin homeostasis.

  Pharmacology & therapeutics 20070601

• Two reaction pathways for transformation of high potential cytochrome b559 of PS II into the intermediate potential form.

  Biochimica et biophysica acta 20070601

• Unique peroxidase reaction mechanism in prostaglandin endoperoxide H synthase-2: compound I in prostaglandin endoperoxide H synthase-2 can be formed without assistance by distal glutamine residue.

  The Journal of biological chemistry 20070601

• Induction of isoforms of tetrapyrrole biosynthetic enzymes, AtHEMA2 and AtFC1, under stress conditions and their physiological functions in Arabidopsis.

  Plant physiology 20070601

• Iron utilization and metabolism in plants.

  Current opinion in plant biology 20070601

• Inhibition of cyclooxygenases by dipyrone.

  British journal of pharmacology 20070601

• Irreversible cross-linking of heme to the distal tryptophan of stromal ascorbate peroxidase in response to rapid inactivation by H2O2.

  The FEBS journal 20070601

• Tyrosine-heme ligation in heme-peptide complex: design based on conserved motif of catalase.

  Journal of peptide science : an official publication of the European Peptide Society 20070601

• Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase.

  Natural product reports 20070601

• Probing the role of the conserved beta-II turn Pro-76/Gly-77 of mitochondrial cytochrome c.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20070601

• Expression of genes involved in heme biosynthesis in the human retinoblastoma cell lines WERI-Rb-1 and Y79: implications for photodynamic therapy.

  Journal of experimental & clinical cancer research : CR 20070601

• Combined experimental and theoretical study on aromatic hydroxylation by mononuclear nonheme iron(IV)-oxo complexes.

  Inorganic chemistry 20070528

• Non-heme iron(II) complexes are efficient olefin aziridination catalysts.

  Chemical communications (Cambridge, England) 20070528

• GATA-1 self-association controls erythroid development in vivo.

  The Journal of biological chemistry 20070525

• Laser photoexcitation of NAD(P)H induces reduction of P450 BM3 heme domain on the microsecond time scale.

  Journal of the American Chemical Society 20070523

• Resonance Raman observation of the structural dynamics of FixL on signal transduction and ligand discrimination.

  Biochemistry 20070522

• Characterization of the outer membrane receptor ShuA from the heme uptake system of Shigella dysenteriae. Substrate specificity and identification of the heme protein ligands.

  The Journal of biological chemistry 20070518

• Induction of heme oxygenase-1 in renovascular hypertension is associated with inhibition of apoptosis.

  Cellular and molecular biology (Noisy-le-Grand, France) 20070515

• Iron(II) complexes with amide-containing macrocycles as non-heme porphyrin analogues.

  Inorganic chemistry 20070514

• Further insights into the spectroscopic properties, electronic structure, and kinetics of formation of the heme-peroxo-copper complex [(F8TPP)FeIII-(O2(2-)-CuII(TMPA)]+.

  Inorganic chemistry 20070514

• High-stability semiquinone intermediate in nitrate reductase A (NarGHI) from Escherichia coli is located in a quinol oxidation site close to heme bD.

  Biochemistry 20070508

• Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.

  Journal of medicinal chemistry 20070503

• Direct measurement by laser flash photolysis of intraprotein electron transfer in a rat neuronal nitric oxide synthase.

  Journal of the American Chemical Society 20070502

• Targeting heme-oxidized soluble guanylate cyclase: solution for all cardiorenal problems in heart failure?

  Hypertension (Dallas, Tex. : 1979) 20070501

• Targeting heme-oxidized soluble guanylate cyclase in experimental heart failure.

  Hypertension (Dallas, Tex. : 1979) 20070501

• NikA binds heme: a new role for an Escherichia coli periplasmic nickel-binding protein.

  Biochemistry 20070501

• Loss of ATP hydrolysis activity by CcmAB results in loss of c-type cytochrome synthesis and incomplete processing of CcmE.

  The FEBS journal 20070501

• A dedicated haem lyase is required for the maturation of a novel bacterial cytochrome c with unconventional covalent haem binding.

  Molecular microbiology 20070501

• The potential of increased meat intake to improve iron nutrition in rural Kenyan schoolchildren.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20070501

• Modulation by heme and zinc protoporphyrin of colonic heme oxygenase-1 and experimental inflammatory bowel disease in the rat.

  European journal of pharmacology 20070430

• N-methyltetrahydro-beta-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic beta-carbolinium cations by heme peroxidases.

  Biochemical and biophysical research communications 20070427

• Proton-directed redox control of O-O bond activation by heme hydroperoxidase models.

  Journal of the American Chemical Society 20070425

• A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence.

  Cell host & microbe 20070419

• RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload.

  Blood 20070415

• The structures and electronic configuration of compound I intermediates of Helicobacter pylori and Penicillium vitale catalases determined by X-ray crystallography and QM/MM density functional theory calculations.

  Journal of the American Chemical Society 20070411

• Crystal structure of the heme-IsdC complex, the central conduit of the Isd iron/heme uptake system in Staphylococcus aureus.

  The Journal of biological chemistry 20070406

• Arthromyces ramosus peroxidase produces two chlorinating species.

  Biochemical and biophysical research communications 20070406

• Kinetic analysis of the conversion of nonheme (alkylperoxo)iron(III) species to iron(IV) complexes.

  Inorganic chemistry 20070402

• Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias.

  Blood 20070401

• Visible spectra of type II cytochrome P450-drug complexes: evidence that 'incomplete' heme coordination is common.

  Drug metabolism and disposition: the biological fate of chemicals 20070401

• The inactivation of cytochrome P450 3A5 by 17alpha-ethynylestradiol is cytochrome b5-dependent: metabolic activation of the ethynyl moiety leads to the formation of glutathione conjugates, a heme adduct, and covalent binding to the apoprotein.

  The Journal of pharmacology and experimental therapeutics 20070401

• Effect of active site and surface mutations on the reduction potential of yeast cytochrome c peroxidase and spectroscopic properties of the oxidized and reduced enzyme.

  Journal of inorganic biochemistry 20070401

• Method for determination of association and dissociation rate constants of reversible bimolecular reactions by isothermal titration calorimeters.

  Analytical chemistry 20070401

• Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium.

  Experimental cell research 20070401

• Sequence and the developmental and tissue-specific regulation of the first complete vitellogenin messenger RNA from ticks responsible for heme sequestration.

  Insect biochemistry and molecular biology 20070401

• Structures of cyanide, nitric oxide and hydroxylamine complexes of Arthromyces ramosusperoxidase at 100 K refined to 1.3 A resolution: coordination geometries of the ligands to the haem iron.

  Acta crystallographica. Section D, Biological crystallography 20070401

• Glutamic acid-141: a heme 'bodyguard' in anionic tobacco peroxidase.

  Biological chemistry 20070401

• Heme requirement and intracellular trafficking in Trypanosoma cruzi epimastigotes.

  Biochemical and biophysical research communications 20070330

• Crystal structure of CO-sensing transcription activator CooA bound to exogenous ligand imidazole.

  Journal of molecular biology 20070330

• Molecular dynamics study on the solvent dependent heme cooling following ligand photolysis in carbonmonoxy myoglobin.

  The journal of physical chemistry. B 20070329

• Glutamate 107 in subunit I of the cytochrome bd quinol oxidase from Escherichia coli is protonated and near the heme d/heme b595 binuclear center.

  Biochemistry 20070320

• Assignment of the ferriheme resonances of the low-spin complexes of nitrophorins 1 and 4 by (1)H and (13)C NMR spectroscopy: comparison to structural data obtained from X-ray crystallography.

  Inorganic chemistry 20070319

• Cardiolipin is associated with the terminal oxidase of an extremely halophilic archaeon.

  Biochemical and biophysical research communications 20070316

• Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration.

  Circulation research 20070316

• Up-regulation of alpha1-microglobulin by hemoglobin and reactive oxygen species in hepatoma and blood cell lines.

  Free radical biology & medicine 20070315

• An IR study of protonation changes associated with heme-heme electron transfer in bovine cytochrome c oxidase.

  Journal of the American Chemical Society 20070314

• FTIR studies of the redox partner interaction in cytochrome P450: the Pdx-P450cam couple.

  Biochimica et biophysica acta 20070301

• The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract.

  Carcinogenesis 20070301

• Structural analysis of cytochromes P450 shows differences in flexibility of heme 2- and 4-vinyls.

  Biochimica et biophysica acta 20070301

• Modulation of protein tyrosine nitration and inflammatory mediators by isoprenylhydroquinone glucoside.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070301

• Theoretical investigations of the hydrolysis pathway of verdoheme to biliverdin.

  Journal of inorganic biochemistry 20070301

• Theoretical density functional theory studies on interactions of small biologically active molecules with isolated heme group.

  Journal of computational chemistry 20070301

• Inhibition of reversed electron transfer and proton transport in the beef heart cytochrome bc1 complex by chemical modification.

  Journal of biochemistry 20070301

• Heme binding inhibits the fibrillization of amyloidogenic apomyoglobin and determines lack of aggregate cytotoxicity.

  Protein science : a publication of the Protein Society 20070301

• Cloning, characterization and localization of a novel basic peroxidase gene from Catharanthus roseus.

  The FEBS journal 20070301

• Functional roles of the heme architecture and its environment in tetraheme cytochrome c.

  Accounts of chemical research 20070301

• Intrarenal renin-angiotensin system and counteracting protective mechanisms in angiotensin II-dependent hypertension.

  Acta physiologica Hungarica 20070301

• Comment on: 'A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production' by Heyer et al. [Toxicol. Lett. 161 (2006) 159-166].

  Toxicology letters 20070227

• Autocatalytic formation of a covalent link between tryptophan 41 and the heme in ascorbate peroxidase.

  Biochemistry 20070227

• Reaction of Aplysia limacina metmyoglobin with hydrogen peroxide.

  Dalton transactions (Cambridge, England : 2003) 20070227

• Synchronous photoinitiation of endothelial NO synthase activity by a nanotrigger targeted at its NADPH site.

  Journal of the American Chemical Society 20070221

• X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase.

  Biochemistry 20070220

• Molecular basis for nitric oxide dynamics and affinity with Alcaligenes xylosoxidans cytochrome c.

  The Journal of biological chemistry 20070216

• Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway.

  The Journal of biological chemistry 20070216

• Axial coordination of heme in ferric CcmE chaperone characterized by EPR spectroscopy.

  Biophysical journal 20070215

• Cytochrome C in a dry trehalose matrix: structural and dynamical effects probed by x-ray absorption spectroscopy.

  Biophysical journal 20070215

• Radical energies and the regiochemistry of addition to heme groups. Methylperoxy and nitrite radical additions to the heme of horseradish peroxidase.

  Journal of the American Chemical Society 20070214

• Abacavir modulates peroxynitrite-mediated oxidation of ferrous nitrosylated human serum heme-albumin.

  Biochemical and biophysical research communications 20070209

• Ab initio molecular dynamics of heme in cytochrome c.

  The journal of physical chemistry. B 20070208

• Role of the peripheral heme oxygenase-carbon monoxide pathway on the nociceptive response of rats to the formalin test: evidence for a cGMP signaling pathway.

  European journal of pharmacology 20070205

• Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats.

  Carcinogenesis 20070201

• DNA binding by an imidazole-sensing CooA variant is dependent on the heme redox state.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070201

• Optical band splitting and electronic perturbations of the heme chromophore in cytochrome C at room temperature probed by visible electronic circular dichroism spectroscopy.

  Biophysical journal 20070201

• Roles of distal arginine in activity and stability of Coprinus cinereus peroxidase elucidated by kinetic and NMR analysis of the Arg51Gln, -Asn, -Leu, and -Lys mutants.

  Journal of inorganic biochemistry 20070201

• Thioquinolobactin, a Pseudomonas siderophore with antifungal and anti-Pythium activity.

  Environmental microbiology 20070201

• Enterohaemorrhagic Escherichia coli O157 and non-O157 serovars differ in their mechanisms for iron supply.

  International journal of medical microbiology : IJMM 20070201

• Compensatory secondary structure alterations in protein glycation.

  Biochimica et biophysica acta 20070201

• Covalent heme attachment in Synechocystis hemoglobin is required to prevent ferrous heme dissociation.

  Protein science : a publication of the Protein Society 20070201

• Alcohols induce beta-hematin formation via the dissociation of aggregated heme and reduction in interfacial tension of the solution.

  Acta tropica 20070201

• Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.

  Cell metabolism 20070201

• Genetic aspects of porphyria cutanea tarda.

  Seminars in liver disease 20070201

• Aminolevulinic acid and photodynamic combination therapy in the treatment of actinic keratoses: caring for the patient.

  Dermatology nursing 20070201

• Cloning and expression of zebrafish genes encoding the heme synthesis enzymes uroporphyrinogen III synthase (UROS) and protoporphyrinogen oxidase (PPO).

  DNA sequence : the journal of DNA sequencing and mapping 20070201

• De novo design of DeltaF -containing heme-binding peptides.

  Chemical biology & drug design 20070201

• The crystal structure of the secreted dimeric form of the hemophore HasA reveals a domain swapping with an exchanged heme ligand.

  Journal of molecular biology 20070126

• NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism.

  The EMBO journal 20070124

• Design of a functional membrane protein by engineering a heme-binding site in glycophorin A.

  Journal of the American Chemical Society 20070124

• Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation.

  Biochemistry 20070116

• [Main symptom jaundice--differential diagnosis at the bedside].

  Medizinische Klinik (Munich, Germany : 1983) 20070115

• Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs.

  The Journal of biological chemistry 20070112

• Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis.

  Biochemistry 20070109

• Thermodynamic investigation into the mechanisms of proton-coupled electron transfer events in heme protein maquettes.

  Biochemistry 20070109

• Weak-field anions displace the histidine ligand in a synthetic heme peptide but not in N-acetylmicroperoxidase-8: possible role of heme geometry differences.

  Inorganic chemistry 20070108

• Oxidative N-dealkylation reactions by oxoiron(IV) complexes of nonheme and heme ligands.

  Inorganic chemistry 20070108

• Electronic effects of peripheral substituents at porphyrin meso positions.

  The Journal of organic chemistry 20070105

• Role of the locus coeruleus carbon monoxide pathway in endotoxin fever in rats.

  Pflugers Archiv : European journal of physiology 20070101

• Interactions between substrates and the haem-bound nitric oxide of ferric and ferrous bacterial nitric oxide synthases.

  The Biochemical journal 20070101

• Motexafin gadolinium-induced cell death correlates with heme oxygenase-1 expression and inhibition of P450 reductase-dependent activities.

  Molecular pharmacology 20070101

• Protonated heme.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• Heme of consumed red meat can act as a catalyst of oxidative damage and could initiate colon, breast and prostate cancers, heart disease and other diseases.

  Medical hypotheses 20070101

• Concomitant administration of Moringa oleifera seed powder in the remediation of arsenic-induced oxidative stress in mouse.

  Cell biology international 20070101

• Two alternative substrate paths for compound I formation and reduction in catalase-peroxidase KatG from Burkholderia pseudomallei.

  Proteins 20070101

• Heme crevice disorder after sixth ligand displacement in the cytochrome c-551 family.

  Archives of biochemistry and biophysics 20070101

• Protein tyrosine nitration induced by heme/hydrogen peroxide: inhibitory effect of hydroxycinnamoyl conjugates.

  Planta medica 20070101

• Oxidative stress impairs heme detoxification in the midgut of the cattle tick, Rhipicephalus (Boophilus) microplus.

  Molecular and biochemical parasitology 20070101

• Crystal structure and ligand binding properties of the truncated hemoglobin from Geobacillus stearothermophilus.

  Archives of biochemistry and biophysics 20070101

• When is a heme transporter not a heme transporter? When it's a folate transporter.

  Cell metabolism 20070101

• Haem recognition by a Staphylococcus aureus NEAT domain.

  Molecular microbiology 20070101

• 4-hydroxynonenal in foodstuffs: heme concentration, fatty acid composition and freeze-drying are determining factors.

  Redox report : communications in free radical research 20070101

• Iron bioavailability as a protective factor against anemia among children aged 12 to 16 months.

  Jornal de pediatria 20070101

• [On the mechanism of photoinduced electron transfer in photosystem II reaction centers].

  Biofizika 20070101

• DNA-directed immobilization of horseradish peroxidase-DNA conjugates on microelectrode arrays: towards electrochemical screening of enzyme libraries.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease.

  Cardiovascular drug reviews 20070101

• Methods for studying iron metabolism in yeast mitochondria.

  Methods in cell biology 20070101

• Synthetic models of the active site of cytochrome C oxidase: influence of tridentate or tetradentate copper chelates bearing a His--Tyr linkage mimic on dioxygen adduct formation by heme/Cu complexes.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• Blood pressure-independent effect of long-term treatment with the soluble heme-independent guanylyl cyclase activator HMR1766 on progression in a model of noninflammatory chronic renal damage.

  Kidney & blood pressure research 20070101

• Albumin-quercetin combination offers a therapeutic advantage in the prevention of reduced survival of erythrocytes in visceral leishmaniasis.

  Blood cells, molecules & diseases 20070101

• Raman microscopy of porcine inner retinal layers from the area centralis.

  Molecular vision 20070101

• Iron chelated cyclic peptide, ferrichrysin, for oral treatment of iron deficiency: solution properties and efficacy in anemic rats.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20070101

• Histidine and not tyrosine is required for the peroxide-induced formation of haem to protein cross-linked myoglobin.

  IUBMB life 20070101

• Bach1, a heme-dependent transcription factor, reveals presence of multiple heme binding sites with distinct coordination structure.

  IUBMB life 20070101

• A global role for zebrafish klf4 in embryonic erythropoiesis.

  Mechanisms of development 20070101

• [Heme oxygenase as a potential therapeutic target for hepatoprotection].

  Przeglad lekarski 20070101

• Analysis of the interactions of cytochrome b5 with flavocytochrome P450 BM3 and its domains.

  Drug metabolism reviews 20070101

• Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice.

  Drug metabolism reviews 20070101

• [Management of pregnancy in women with acute porphyria. Case reports].

  Terapevticheskii arkhiv 20070101

• The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily.

  BMC biochemistry 20070101

• A new mutation within the porphobilinogen deaminase gene leading to a truncated protein as a cause of acute intermittent porphyria in an extended Indian family.

  Folia biologica 20070101

• Differential sensing of protein influences by NO and CO vibrations in heme adducts.

  Journal of the American Chemical Society 20061227

• Evolutionary migration of a post-translationally modified active-site residue in the proton-pumping heme-copper oxygen reductases.

  Biochemistry 20061226

• Glutamates 99 and 107 in transmembrane helix III of subunit I of cytochrome bd are critical for binding of the heme b595-d binuclear center and enzyme activity.

  Biochemistry 20061226

• Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.

  The Journal of biological chemistry 20061222

• Haem carrier protein 1 (HCP1): Expression and functional studies in cultured cells.

  FEBS letters 20061222

• Experimental evidence for proton motive force-dependent catalysis by the diheme-containing succinate:menaquinone oxidoreductase from the Gram-positive bacterium Bacillus licheniformis.

  Biochemistry 20061219

• X-ray structure of the membrane-bound cytochrome c quinol dehydrogenase NrfH reveals novel haem coordination.

  The EMBO journal 20061213

• Fungal heme oxygenases: Functional expression and characterization of Hmx1 from Saccharomyces cerevisiae and CaHmx1 from Candida albicans.

  Biochemistry 20061212

• Divergent evolutionary lines of fungal cytochrome c peroxidases belonging to the superfamily of bacterial, fungal and plant heme peroxidases.

  FEBS letters 20061211

• Stoichiometric and catalytic secondary O-atom transfer by Fe(III)-NO2 complexes derived from a planar tetradentate non-heme ligand: reminiscence of heme chemistry.

  Inorganic chemistry 20061211

• Low frequency resonance Raman spectra of isolated alpha and beta subunits of hemoglobin and their deuterated analogues.

  Biopolymers 20061205

• Resonance Raman study of ferric heme adducts of dehaloperoxidase from Amphitrite ornata.

  Biochemistry 20061205

• Electrochemistry of cytochrome P450 BM3 in sodium dodecyl sulfate films.

  Langmuir : the ACS journal of surfaces and colloids 20061205

• Dynamics of NO rebinding to the heme domain of NO synthase-like proteins from bacterial pathogens.

  Nitric oxide : biology and chemistry 20061201

• Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects.

  The Journal of pharmacology and experimental therapeutics 20061201

• Infrared absorption study of the heme pocket dynamics of carbonmonoxyheme proteins.

  Biophysical journal 20061201

• Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase.

  The Journal of biological chemistry 20061201

• Soluble guanylate cyclase.

  Current opinion in structural biology 20061201

• Structure of the Escherichia coli O157:H7 heme oxygenase ChuS in complex with heme and enzymatic inactivation by mutation of the heme coordinating residue His-193.

  The Journal of biological chemistry 20061201

• Structural insights into pathogenic mutations in heme-dependent cystathionine-beta-synthase.

  Journal of inorganic biochemistry 20061201

• Contribution of the heme propionate groups to the electron transfer and electrostatic properties of myoglobin.

  Journal of inorganic biochemistry 20061201

• Spectroscopic characterization of a higher plant heme oxygenase isoform-1 from Glycine max (soybean)--coordination structure of the heme complex and catabolism of heme.

  The FEBS journal 20061201

• Spectroscopic investigations of intermediates in the reaction of cytochrome P450(BM3)-F87G with surrogate oxygen atom donors.

  Journal of inorganic biochemistry 20061201

• Molecular replacement in the 'twilight zone': structure determination of the non-haem iron oxygenase NovR from Streptomyces spheroides through repeated density modification of a poor molecular-replacement solution.

  Acta crystallographica. Section D, Biological crystallography 20061201

• The formation of g=2.49-species of cytochrome P450 in the rat liver by PCB126 oral administration: identification of heme axial ligands by EPR spectroscopy.

  Bioscience, biotechnology, and biochemistry 20061201

• Effect of lead (Pb) exposure on the activity of superoxide dismutase and catalase in battery manufacturing workers (BMW) of Western Maharashtra (India) with reference to heme biosynthesis.

  International journal of environmental research and public health 20061201

• Inhibition of cytochrome P450 3A4 by a pyrimidineimidazole: Evidence for complex heme interactions.

  Chemical research in toxicology 20061201

• Characterization of carbon monoxide photodissociation from Fe(II)LPO with photoacoustic calorimetry.

  The journal of physical chemistry. B 20061130

• An isocyanide probe for heme electronic structure: bis(tert-butylisocyanide) complex of diazaporphyrin showing a unique (dxy)2(dxz, dyz)3 ground state.

  Chemical communications (Cambridge, England) 20061128

• Structural and dynamic repercussions of heme binding and heme-protein cross-linking in Synechococcus sp. PCC 7002 hemoglobin.

  Biochemistry 20061128

• The cytochrome P450 gene family CYP157 does not contain EXXR in the K-helix reducing the absolute conserved P450 residues to a single cysteine.

  FEBS letters 20061127

• Small molecule directed aggregation of a heme peptide on gold: an STM study.

  The journal of physical chemistry. B 20061123

• A histidine/tryptophan pi-stacking interaction stabilizes the heme-independent folding core of microsomal apocytochrome b5 relative to that of mitochondrial apocytochrome b5.

  Biochemistry 20061121

• Spectroelectrochemistry of type II cytochrome c3 on a glycosylated self-assembled monolayer.

  Langmuir : the ACS journal of surfaces and colloids 20061121

• NADPH oxidase-derived ROS: key modulators of heme-induced mitochondrial stability in human neutrophils.

  Experimental cell research 20061115

• A functional model for the cysteinate-ligated non-heme iron enzyme superoxide reductase (SOR).

  Journal of the American Chemical Society 20061115

• Moving toward a more physiological model: application of mucin to refine the in vitro digestion/Caco-2 cell culture system.

  Journal of agricultural and food chemistry 20061115

• Heme-heme interactions in the cytochrome b6f complex: EPR spectroscopy and correlation with structure.

  Journal of the American Chemical Society 20061108

• An adolescent girl with Meyer-Betz syndrome.

  Clinical rheumatology 20061101

• Carbon monoxide contributes to hypotension-induced cerebrovascular vasodilation in piglets.

  American journal of physiology. Heart and circulatory physiology 20061101

• Oxidation and haem loss kinetics of poly(ethylene glycol)-conjugated haemoglobin (MP4): dissociation between in vitro and in vivo oxidation rates.

  The Biochemical journal 20061101

• Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo.

  The Biochemical journal 20061101

• Analysis of conserved glutamate residues in Porphyromonas gingivalis outer membrane receptor HmuR: toward a further understanding of heme uptake.

  Archives of microbiology 20061101

• Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450(cam) by an L244A mutation.

  Protein engineering, design & selection : PEDS 20061101

• Elevated zinc protoporphyrin/heme ratios in umbilical cord blood after diabetic pregnancy.

  Journal of perinatology : official journal of the California Perinatal Association 20061101

• New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acid.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20061101

• Heme binding to Amyloid-beta peptide: mechanistic role in Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 20061101

• Role of prostaglandins in heme-induced fever.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101

• Conformation of the c552:aa3 electron transfer complex in Paracoccus denitrificans studied by EPR on oriented samples.

  FEBS letters 20061030

• 13C NMR spectroscopy of core heme carbons as a simple tool to elucidate the coordination state of ferric high-spin heme proteins.

  Inorganic chemistry 20061030

• The quinone binding site in Escherichia coli succinate dehydrogenase is required for electron transfer to the heme b.

  The Journal of biological chemistry 20061027

• Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin.

  Circulation research 20061027

• Characterization of the heme binding properties of Staphylococcus aureus IsdA.

  Biochemistry 20061024

• Pentacoordinate and hexacoordinate ferric hemes in acid medium: EPR, UV-Vis and CD studies of the giant extracellular hemoglobin of Glossoscolex paulistus.

  Biophysical chemistry 20061020

• The first structure from the SOUL/HBP family of heme-binding proteins, murine P22HBP.

  The Journal of biological chemistry 20061020

• Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier.

  The Journal of biological chemistry 20061020

• The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase. Electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN.

  The Journal of biological chemistry 20061020

• Evaluating the roles of the heme a side chains in cytochrome c oxidase using designed heme proteins.

  Biochemistry 20061017

• Heme coordination states of unfolded ferrous cytochrome C.

  Biophysical journal 20061015

• Regulatory interactions between ubiquinol oxidation and ubiquinone reduction sites in the dimeric cytochrome bc1 complex.

  The Journal of biological chemistry 20061013

• State preparation and excited electronic and vibrational behavior in hemes.

  The journal of physical chemistry. B 20061012

• Cofacial heme binding is linked to dimerization by a bacterial heme transport protein.

  Journal of molecular biology 20061006

• Identification of a mammalian mitochondrial porphyrin transporter.

  Nature 20061005

• Solution 1H NMR characterization of the axial bonding of the two His in oxidized human cytoglobin.

  Journal of the American Chemical Society 20061004

• Polymerization efficacy of simplified adhesive systems studied by NMR and MRI techniques.

  Dental materials : official publication of the Academy of Dental Materials 20061001

• In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin.

  Blood 20061001

• Respiratory chain deficiency slows down cell-cycle progression via reduced ROS generation and is associated with a reduction of p21CIP1/WAF1.

  Journal of cellular physiology 20061001

• Redox infrared markers of the heme and axial ligands in microperoxidase: Bases for the analysis of c-type cytochromes.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20061001

• Expression and characterization of the assimilatory NADH-nitrite reductase from the phototrophic bacterium Rhodobacter capsulatus E1F1.

  Archives of microbiology 20061001

• Characterization of peroxide-bound heme species generated in the reaction of thermally tolerant cytochrome c552 with hydrogen peroxide.

  Chembiochem : a European journal of chemical biology 20061001

• Characterization of heme-coordinating histidyl residues of cytochrome b5 based on the reactivity with diethylpyrocarbonate: a mechanism for the opening of axial imidazole rings.

  Journal of biochemistry 20061001

• Proximal influences in two-on-two globins: effect of the Ala69Ser replacement on Synechocystis sp. PCC 6803 hemoglobin.

  Biochemistry 20060926

• Expression of human myoglobin in H9c2 cells enhances toxicity to added hydrogen peroxide.

  Biochemical and biophysical research communications 20060922

• Roles of the heme and heme ligands in the activation of CooA, the CO-sensing transcriptional activator.

  Biochemical and biophysical research communications 20060922

• Probing the unusual oxidation/reduction behavior of Paracoccus pantotrophus cytochrome cd1 nitrite reductase by replacing a switchable methionine heme iron ligand with histidine.

  Biochemistry 20060919

• Active-site models of bacterial nitric oxide reductase featuring tris-histidyl and glutamic acid mimics: influence of a carboxylate ligand on Fe(B) binding and the heme Fe/Fe(B) redox potential.

  Inorganic chemistry 20060918

• Structure and dynamics of dioxygen bound to cobalt and iron heme.

  Biophysical journal 20060915

• Measurement of nitric oxide levels in the red cell: validation of tri-iodide-based chemiluminescence with acid-sulfanilamide pretreatment.

  The Journal of biological chemistry 20060915

• Structural and chemical changes of the P(M) intermediate of paracoccus denitrificans cytochrome c oxidase revealed by IR spectroscopy with labeled tyrosines and histidine.

  Biochemistry 20060912

• The role of tetrahydrobiopterin in catalysis by nitric oxide synthase.

  Chemical communications (Cambridge, England) 20060907

• Role of the PEWY glutamate in hydroquinone-quinone oxidation-reduction catalysis in the Qo Site of cytochrome bc1.

  Biochemistry 20060905

• Regulation of soluble guanylyl cyclase: looking beyond NO.

  American journal of physiology. Lung cellular and molecular physiology 20060901

• Proton NMR study of myoglobin reconstituted with 3, 7-diethyl-2, 8-dimethyl iron porphyrin: remarkable influence of peripheral substitution on heme rotation.

  Journal of inorganic biochemistry 20060901

• Theoretical investigations of the reactivity of verdoheme analogues: opening of the planar macrocycle by amide, dimethyl amide, and hydroxide nucleophiles to form helical biliverdin type complexes.

  Journal of inorganic biochemistry 20060901

• A role for sterol levels in oxygen sensing in Saccharomyces cerevisiae.

  Genetics 20060901

• Iron(III) complexes of certain meridionally coordinating tridentate ligands as models for non-heme iron enzymes: the role of carboxylate coordination.

  Journal of inorganic biochemistry 20060901

• Protoporphyrin IX generation from delta-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation.

  American journal of physiology. Lung cellular and molecular physiology 20060901

• Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.

  The Journal of clinical investigation 20060901

• Cardiolipin activates cytochrome c peroxidase activity since it facilitates H(2)O(2) access to heme.

  Biochemistry. Biokhimiia 20060901

• Iron dysregulation in Friedreich ataxia.

  Seminars in pediatric neurology 20060901

• Darwin at the molecular scale: selection and variance in electron tunnelling proteins including cytochrome c oxidase.

  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20060829

• Conformational mobility in the active site of a heme peroxidase.

  The Journal of biological chemistry 20060825

• Estimation of the orientation of heme in cytochrome C immobilized on a carboxylate-terminated alkanethiol monolayer on a au electrode by the use of electroreflectance spectroscopy with polarized light incidence.

  The journal of physical chemistry. B 20060824

• Cyanide binding and heme cavity conformational transitions in Drosophila melanogaster hexacoordinate hemoglobin.

  Biochemistry 20060822

• Drosophila nuclear receptor E75 is a thiolate hemoprotein.

  Biochemistry 20060815

• Role of phenylalanine B10 in plant nonsymbiotic hemoglobins.

  Biochemistry 20060815

• Electronic coupling between heme electron-transfer centers and its decay with distance depends strongly on relative orientation.

  The journal of physical chemistry. B 20060810

• Immobilized hemin affinity chromatography as a probe for proteins having potentiality to bind with heme.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060807

• Mitochondria in hematopoiesis and hematological diseases.

  Oncogene 20060807

• Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase beta1 H-NOX domain.

  The Journal of biological chemistry 20060804

• Towards the mechanism of proton pumping by the haem-copper oxidases.

  Biochimica et biophysica acta 20060801

• S-nitrosohemoglobin: a mechanism for its formation in conjunction with nitrite reduction by deoxyhemoglobin.

  Nitric oxide : biology and chemistry 20060801

• The reactions of neuroglobin with CO: evidence for two forms of the ferrous protein.

  Journal of inorganic biochemistry 20060801

• Optical and EPR spectroscopic studies of demetallation of hemin by L-chain apoferritins.

  Journal of inorganic biochemistry 20060801

• Iron nutrition and physiological responses to iron stress in Nitrosomonas europaea.

  Archives of microbiology 20060801

• Carbon monoxide: from the origin of life to molecular medicine.

  Trends in molecular medicine 20060801

• Effect of mutation on the dissociation and recombination dynamics of CO in transcriptional regulator CooA: a picosecond infrared transient absorption study.

  Biochemistry 20060801

• Siro(haem)amide in Allochromatium vinosum and relevance of DsrL and DsrN, a homolog of cobyrinic acid a,c-diamide synthase, for sulphur oxidation.

  FEMS microbiology letters 20060801

• Staphylococcus aureus redirects central metabolism to increase iron availability.

  PLoS pathogens 20060801

• The mechanism of direct heme transfer from the streptococcal cell surface protein Shp to HtsA of the HtsABC transporter.

  The Journal of biological chemistry 20060728

• A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum.

  The Journal of biological chemistry 20060728

• Structure of cytochrome c6A, a novel dithio-cytochrome of Arabidopsis thaliana, and its reactivity with plastocyanin: implications for function.

  Journal of molecular biology 20060728

• Hydrophobic distal pocket affects NO-heme geminate recombination dynamics in dehaloperoxidase and H64V myoglobin.

  The journal of physical chemistry. B 20060727

• Ligand interactions in the distal heme pocket of Mycobacterium tuberculosis truncated hemoglobin N: roles of TyrB10 and GlnE11 residues.

  Biochemistry 20060725

• Identification of residues crucially involved in soluble guanylate cyclase activation.

  FEBS letters 20060724

• Interactions between nitric oxide and indoleamine 2,3-dioxygenase.

  Biochemistry 20060718

• Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.

  Biochemistry 20060711

• Study on the redox state dependent gamma(CH) vibrational modes of the c-type heme.

  Biopolymers 20060701

• Heme oxygenase induction and biliverdin excretion: implications for the bile fluorescence biomarker.

  Marine environmental research 20060701

• Modeling proline ligation in the heme-dependent CO sensor, CooA, using small-molecule analogs.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20060701

• Metabolic maps and functions of the Plasmodium mitochondrion.

  FEMS microbiology reviews 20060701

• Time-dependent atomic coordinates for the dissociation of carbon monoxide from myoglobin.

  Acta crystallographica. Section D, Biological crystallography 20060701

• Quenchers induce wavelength dependence on protein fluorescence lifetimes.

  Journal of fluorescence 20060701

• Biosynthesis of heme in mammals.

  Biochimica et biophysica acta 20060701

• Oxidative alterations of cyclooxygenase during atherogenesis.

  Prostaglandins & other lipid mediators 20060701

• Existence of aa3-type ubiquinol oxidase as a terminal oxidase in sulfite oxidation of Acidithiobacillus thiooxidans.

  Bioscience, biotechnology, and biochemistry 20060701

• Relationship between NMR shielding and heme binding strength for a series of 7-substituted quinolines.

  The journal of physical chemistry. A 20060629

• Ultrafast heme dynamics in ferrous versus ferric cytochrome c studied by time-resolved resonance Raman and transient absorption spectroscopy.

  The journal of physical chemistry. B 20060629

• Crystal structure of oxidized cytochrome c(6A) from Arabidopsis thaliana.

  FEBS letters 20060626

• Role of MIF and glutathione, in association with fetal ovine globin chain (Hbgamma) and LPS, in induction of TNFalpha from cells of young and aged mice, and PBL from healthy human populations.

  Immunology letters 20060615

• Carbon monoxide and biliverdin prevent endothelial cell sloughing in rats with type I diabetes.

  Free radical biology & medicine 20060615

• Electron transfer among the CuA-, heme b- and a3-centers of Thermus thermophilus cytochrome ba3.

  FEBS letters 20060612

• Evaluation of electron-withdrawing group effects on heme binding in designed proteins: implications for heme a in cytochrome c oxidase.

  Inorganic chemistry 20060612

• Heme oxygenase-1 enhances renal mitochondrial transport carriers and cytochrome C oxidase activity in experimental diabetes.

  The Journal of biological chemistry 20060609

• Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity.

  Oncogene 20060608

• Heme oxygenase-1 and cardiovascular disease.

  Histology and histopathology 20060601

• The heme environment of mouse neuroglobin: histidine imidazole plane orientations obtained from solution NMR and EPR spectroscopy as compared with X-ray crystallography.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20060601

• The haemoxisome: a haem-iron containing structure in the Rhodnius prolixus midgut cells.

  Journal of insect physiology 20060601

• Heme oxygenase-1 and transplantation tolerance.

  Human immunology 20060601

• The HA2 haemagglutinin domain of the lysine-specific gingipain (Kgp) of Porphyromonas gingivalis promotes micro-oxo bishaem formation from monomeric iron(III) protoporphyrin IX.

  Microbiology (Reading, England) 20060601

• [Laboratory tests and therapeutic strategies for the porphyrias].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20060601

• Multielectron transfer at heme-functionalized nanocrystalline TiO2: reductive dechlorination of DDT and CCl4 forms stable carbene compounds.

  Nano letters 20060601

• Roles for heme-copper oxidases in extreme high-light and oxidative stress response in the cyanobacterium Synechococcus sp. PCC 7002.

  Archives of microbiology 20060601

• Treatment of an acute attack of porphyria during pregnancy.

  European journal of neurology 20060601

• [A quantum chemistry investigation on antimalarial mechanism of Qinghaosu based on cleavage of the peroxide bridge].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060601

• Catalytic reduction of NO to N2O by a designed heme copper center in myoglobin: implications for the role of metal ions.

  Journal of the American Chemical Society 20060531

• Nitric oxide inhibits peroxidase activity of cytochrome c.cardiolipin complex and blocks cardiolipin oxidation.

  The Journal of biological chemistry 20060526

• Intraprotein electron transfer in a two-domain construct of neuronal nitric oxide synthase: the output state in nitric oxide formation.

  Biochemistry 20060523

• Role of distal arginine in early sensing intermediates in the heme domain of the oxygen sensor FixL.

  Biochemistry 20060516

• Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy.

  Biochemical and biophysical research communications 20060512

• Inhibition of the ERK/MAP kinase pathway attenuates heme oxygenase-1 expression and heme-mediated neuronal injury.

  Neuroscience letters 20060508

• On the relationship of coral allene oxide synthase to catalase. A single active site mutation that induces catalase activity in coral allene oxide synthase.

  The Journal of biological chemistry 20060505

• Hap4 is not essential for activation of respiration at low specific growth rates in Saccharomyces cerevisiae.

  The Journal of biological chemistry 20060505

• Raman evidence for specific substrate-induced structural changes in the heme pocket of human cytochrome P450 aromatase during the three consecutive oxygen activation steps.

  Biochemistry 20060502

• Redox titration of all electron carriers of cytochrome c oxidase by Fourier transform infrared spectroscopy.

  Biochemistry 20060502

• Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors.

  Bioorganic & medicinal chemistry 20060501

• Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite.

  Journal of lipid research 20060501

• Anti-Plasmodium activity of imidazole-dioxolane compounds.

  Bioorganic & medicinal chemistry letters 20060501

• Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance.

  Trends in molecular medicine 20060501

• Transcription factor NNR from Paracoccus denitrificans is a sensor of both nitric oxide and oxygen: isolation of nnr* alleles encoding effector-independent proteins and evidence for a haem-based sensing mechanism.

  Microbiology (Reading, England) 20060501

• Recombinant cytochromes c biogenesis systems I and II and analysis of haem delivery pathways in Escherichia coli.

  Molecular microbiology 20060501

• NMR and EPR studies of chloroiron(III) tetraphenyl-chlorin and its complexes with imidazoles and pyridines of widely differing basicities.

  Inorganic chemistry 20060501

• Heme arginate pretreatment attenuates pulmonary NF-kappaB and AP-1 activation induced by hemorrhagic shock via heme oxygenase-1 induction.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20060501

• Multiple active site conformers in the carbon monoxide complexes of trematode hemoglobins.

  The Journal of biological chemistry 20060428

• Hydroxyl radical scavenging reactivity of proton pump inhibitors.

  Biochemical pharmacology 20060428

• Evidence for displacements of the C-helix by CO ligation and DNA binding to CooA revealed by UV resonance Raman spectroscopy.

  The Journal of biological chemistry 20060421

• Deactivation mechanisms of chloroperoxidase during biotransformations.

  Biotechnology and bioengineering 20060420

• Cytochrome b(5) is a major reductant in vivo of human indoleamine 2,3-dioxygenase expressed in yeast.

  FEBS letters 20060417

• A weak Fe-O bond in the oxygenated complex of the nitric-oxide synthase of Staphylococcus aureus.

  The Journal of biological chemistry 20060414

• Role of heme iron coordination and protein structure in the dynamics and geminate rebinding of nitric oxide to the H93G myoglobin mutant: implications for nitric oxide sensors.

  The Journal of biological chemistry 20060414

• Photon echo spectroscopy of porphyrins and heme proteins: effects of quasidegenerate electronic structure on the peak shift decay.

  The Journal of chemical physics 20060414

• Structure and reactivity of a thermostable prokaryotic nitric-oxide synthase that forms a long-lived oxy-heme complex.

  The Journal of biological chemistry 20060407

• Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.

  The Journal of biological chemistry 20060407

• Proton-coupled electron transfer drives the proton pump of cytochrome c oxidase.

  Nature 20060406

• Characterization and redox properties of cytochrome c552 from Thermus thermophilus adsorbed on different self-assembled thiol monolayers, used to model the chemical environment of the redox partner.

  Biopolymers 20060405

• Influence of reduction of heme a and Cu(A) on the oxidized catalytic center of cytochrome c oxidase: insight from organic solvents.

  Biochemistry 20060404

• Biochemistry and pharmacology of novel anthranilic acid derivatives activating heme-oxidized soluble guanylyl cyclase.

  Molecular pharmacology 20060401

• Lack of allosterically controlled intramolecular transfer of nitric oxide from the heme to cysteine in the beta subunit of hemoglobin.

  Blood 20060401

• Linker chains of the gigantic hemoglobin of the earthworm Lumbricus terrestris: primary structures of linkers L2, L3, and L4 and analysis of the connectivity of the disulfide bonds in linker L1.

  Proteins 20060401

• The metal complexes of N-confused porphyrin as heme model compounds.

  Journal of inorganic biochemistry 20060401

• The role of the heme propionates in heme biochemistry.

  Journal of inorganic biochemistry 20060401

• Nitric oxide signaling: no longer simply on or off.

  Trends in biochemical sciences 20060401

• Uroporphyrinogen III synthase knock-in mice have the human congenital erythropoietic porphyria phenotype, including the characteristic light-induced cutaneous lesions.

  American journal of human genetics 20060401

• Bradyrhizobium japonicum senses iron through the status of haem to regulate iron homeostasis and metabolism.

  Molecular microbiology 20060401

• Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats.

  The Journal of pharmacy and pharmacology 20060401

• Roles of environmental heme, and menaquinone, in streptococcus agalactiae.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20060401

• Effect of glycation of hemoglobin on its interaction with trifluoperazine.

  The protein journal 20060401

• The effect of heme environment on the hydrogen abstraction reaction of camphor in P450cam catalysis: a QM/MM study.

  Journal of the American Chemical Society 20060329

• Dynamics of proteins encapsulated in silica sol-gel glasses studied with IR vibrational echo spectroscopy.

  Journal of the American Chemical Society 20060329

• Differential effects of alkyl- and arylguanidines on the stability and reactivity of inducible NOS heme-dioxygen complexes.

  Biochemistry 20060328

• Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide.

  The Journal of biological chemistry 20060324

• Direct measurement by laser flash photolysis of intramolecular electron transfer in a two-domain construct of murine inducible nitric oxide synthase.

  Journal of the American Chemical Society 20060322

• Crystal structure of human cytochrome P450 2D6.

  The Journal of biological chemistry 20060317

• The 1.6A X-ray structure of the unusual c-type cytochrome, cytochrome cL, from the methylotrophic bacterium Methylobacterium extorquens.

  Journal of molecular biology 20060317

• Rates and Equilibrium of CuA to heme a electron transfer in Paracoccus denitrificans cytochrome c oxidase.

  Biophysical journal 20060315

• Dynamic ligation properties of the Escherichia coli heme chaperone CcmE to non-covalently bound heme.

  The Journal of biological chemistry 20060310

• Comparison of the binding and reactivity of plant and mammalian peroxidases to indole derivatives by computational docking.

  Biochemistry 20060307

• Mitoferrin is essential for erythroid iron assimilation.

  Nature 20060302

• The development of an efficient system for heterologous expression of cytochrome P450s in Escherichia coli using hemA gene co-expression.

  Protein expression and purification 20060301

• Heme deficiency is associated with senescence and causes suppression of N-methyl-D-aspartate receptor subunits expression in primary cortical neurons.

  Molecular pharmacology 20060301

• Interaction of arsine with hemoglobin in arsine-induced hemolysis.

  Toxicological sciences : an official journal of the Society of Toxicology 20060301

• pH-dependent redox and CO binding properties of chelated protoheme-L-histidine and protoheme-glycyl-L-histidine complexes.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20060301

• Three-dimensional model of the human aromatase enzyme and density functional parameterization of the iron-containing protoporphyrin IX for a molecular dynamics study of heme-cysteinato cytochromes.

  Proteins 20060301

• Dissociation and unfolding of inducible nitric oxide synthase oxygenase domain identifies structural role of tetrahydrobiopterin in modulating the heme environment.

  Molecular and cellular biochemistry 20060301

• Products of heme oxygenase and their potential therapeutic applications.

  American journal of physiology. Renal physiology 20060301

• A direct and simultaneous detection of zinc protoporphyrin IX, free protoporphyrin IX, and fluorescent heme degradation product in red blood cell hemolysates.

  Free radical research 20060301

• Recent advances in mammalian haem transport.

  Trends in biochemical sciences 20060301

• Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a heme-regulated phosphodiesterase from Escherichia coli.

  The FEBS journal 20060301

• [Acute intermittent porphyria and oral contraception. Case report].

  Ginekologia polska 20060301

• Roles of the heme distal residues of FixL in O2 sensing: a single convergent structure of the heme moiety is relevant to the downregulation of kinase activity.

  Biochemistry 20060227

• Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation.

  Biochemistry 20060227

• Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease.

  Proceedings of the National Academy of Sciences of the United States of America 20060227

• Phytol-modified heme in mesoporous silica: conjugates as models of hemoproteins.

  Biotechnology and bioengineering 20060220

• A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production.

  Toxicology letters 20060220

• Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450.

  Biotechnology and bioengineering 20060220

• Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.

  Biochemical and biophysical research communications 20060217

• Inhibition assay of beta-hematin formation initiated by lecithin for screening new antimalarial drugs.

  Analytical biochemistry 20060215

• Redox interaction of cytochrome c3 with [NiFe] hydrogenase from Desulfovibrio vulgaris Miyazaki F.

  Biochemistry 20060214

• The copper-enzyme family of dopamine beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase: resolving the chemical pathway for substrate hydroxylation.

  The Journal of biological chemistry 20060210

• Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages.

  The Journal of biological chemistry 20060210

• Resonance Raman study of Bacillus subtilis NO synthase-like protein: similarities and differences with mammalian NO synthases.

  Biochemistry 20060207

• Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes.

  Biochemical and biophysical research communications 20060203

• Multiple haem lyase genes indicate substrate specificity in cytochrome c biogenesis.

  Biochemical Society transactions 20060201

• What is the substrate specificity of the System I cytochrome c biogenesis apparatus?

  Biochemical Society transactions 20060201

• Compound I of heme oxygenase cannot hydroxylate its heme meso-carbon.

  Journal of the American Chemical Society 20060201

• Tetrapyrrole biosynthesis in Rhodobacter capsulatus is transcriptionally regulated by the heme-binding regulatory protein, HbrL.

  Journal of bacteriology 20060201

• Pyrroloquinoline quinone-dependent dehydrogenases from Ketogulonicigenium vulgare catalyze the direct conversion of L-sorbosone to L-ascorbic acid.

  Applied and environmental microbiology 20060201

• Electrochemistry of xanthine oxidase and its interaction with nitric oxide.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060201

• Dehydration in the folding of reduced cytochrome c revealed by the electron-transfer-triggered folding under high pressure.

  Journal of the American Chemical Society 20060125

• Evidence for redox cooperativity between c-type hemes of MauG which is likely coupled to oxygen activation during tryptophan tryptophylquinone biosynthesis.

  Biochemistry 20060124

• Tetranuclear iron(III) complexes of an octadentate pyridine-carboxylate ligand and their catalytic activity in alkane oxidation by hydrogen peroxide.

  Dalton transactions (Cambridge, England : 2003) 20060121

• Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation.

  Blood 20060115

• Non-covalent modification of the heme-pocket of apomyoglobin by a 1,10-phenanthroline derivative.

  Bioorganic & medicinal chemistry letters 20060115

• Easy oxidation and nitration of human myoglobin by nitrite and hydrogen peroxide.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20060111

• Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network.

  Biochemistry 20060110

• Characterization of the Desulfovibrio desulfuricans ATCC 27774 DsrMKJOP complex--a membrane-bound redox complex involved in the sulfate respiratory pathway.

  Biochemistry 20060110

• The membrane anchors of the heme chaperone CcmE and the periplasmic thioredoxin CcmG are functionally important.

  FEBS letters 20060109

• Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism.

  The Journal of pharmacology and experimental therapeutics 20060101

• The effectiveness of oral tin mesoporphyrin prophylaxis in reducing bilirubin production after an oral heme load in a transgenic mouse model.

  Biology of the neonate 20060101

• Modeling truncated hemoglobin vibrational dynamics.

  Proteins 20060101

• Photoaffinity labeling of P450Cam by an imidazole-tethered benzophenone probe.

  Archives of biochemistry and biophysics 20060101

• Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates.

  The FEBS journal 20060101

• Activation and catalysis of the di-heme cytochrome c peroxidase from Paracoccus pantotrophus.

  Structure (London, England : 1993) 20060101

• Regulation of globin gene transcription by heme in erythroleukemia cells: analysis of putative heme regulatory motifs in the p45 NF-E2 transcription factor.

  Antioxidants & redox signaling 20060101

• The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiation.

  Antioxidants & redox signaling 20060101

• Homology modeling and molecular docking study of translationally controlled tumor protein and artemisinin.

  Archives of pharmacal research 20060101

• Poly(ethylene glycol)-conjugated human serum albumin including iron porphyrins: surface modification improves the O2-transporting ability.

  Bioconjugate chemistry 20060101

• Use of ALA and ALA derivatives for optimizing ALA-based photodynamic therapy: a review of our experience.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20060101

• Fluorescence diagnosis using enzyme-related metabolic abnormalities of neoplasia.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20060101

• Frataxin, iron-sulfur clusters, heme, ROS, and aging.

  Antioxidants & redox signaling 20060101

• Soret spectral and bioinformatic approaches provide evidence for a critical role of the alpha -subunit in assembly of tetrameric hemoglobin.

  The protein journal 20060101

• Transmembrane traffic in the cytochrome b6f complex.

  Annual review of biochemistry 20060101

• Consequences of the structure of the cytochrome b6f complex for its charge transfer pathways.

  Biochimica et biophysica acta 20060101

• [Interaction between dinitrosyl iron complexes and intermediate products of oxidative stress].

  Biofizika 20060101

• Phototherapy and malignancy: possible enhancement by iron administration and hyperbaric oxygen.

  Medical hypotheses 20060101

• CYP4B1: an enigmatic P450 at the interface between xenobiotic and endobiotic metabolism.

  Drug metabolism reviews 20060101

• The structure and function of frataxin.

  Critical reviews in biochemistry and molecular biology 20060101

• Chimeric antibody-binding Vitreoscilla hemoglobin (VHb) mediates redox-catalysis reaction: new insight into the functional role of VHb.

  International journal of biological sciences 20060101

• Identification and characterization of the heme-binding proteins SeShp and SeHtsA of Streptococcus equi subspecies equi.

  BMC microbiology 20060101

• Ursodesoxycholic acid and heme-arginate are unable to improve hematopoiesis and liver injury in an erythropoietic protoporphyria mouse model.

  Physiological research 20060101

• Biochemical aspects of lead exposure in silver jewelry workers in western Maharashtra (India).

  Journal of basic and clinical physiology and pharmacology 20060101

• Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase.

  Biochimica et biophysica acta 20051230

• Pro-oxidative characteristics of trout hemoglobin and myoglobin: a role for released heme in oxidation of lipids.

  Journal of agricultural and food chemistry 20051228

• The heme of cystathionine beta-synthase likely undergoes a thermally induced redox-mediated ligand switch.

  Biochemistry 20051227

• The ferrous verdoheme-heme oxygenase complex is six-coordinate and low-spin.

  Journal of the American Chemical Society 20051221

• Spectroscopic characterization of hydroxide and aqua complexes of Fe(II)-protoheme, structural models for the axial coordination of the atypical heme of membrane cytochrome b6f complexes.

  Journal of the American Chemical Society 20051221

• Probing heme propionate involvement in transmembrane proton transfer coupled to electron transfer in dihemic quinol:fumarate reductase by 13C-labeling and FTIR difference spectroscopy.

  Biochemistry 20051220

• Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p.

  Biochemistry 20051220

• Clotrimazole inhibits hemoperoxidase of Plasmodium falciparum and induces oxidative stress. Proposed antimalarial mechanism of clotrimazole.

  The Journal of biological chemistry 20051216

• Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells.

  Human molecular genetics 20051215

• Reversible thermal inactivation and conformational states in denaturant guanidinium of a calcium-dependent peroxidase from Euphorbia characias.

  International journal of biological macromolecules 20051215

• Second half-reaction of nitric oxide synthase: computational insights into the initial step and key proposed intermediate.

  The journal of physical chemistry. B 20051215

• Heme binding by the N-terminal fragment 1-44 of human growth hormone.

  Biochemistry 20051213

• Characterization of functional heme domains from soluble guanylate cyclase.

  Biochemistry 20051213

• Evidence for the hydrophobic cavity of heme oxygenase-1 to be a CO-trapping site.

  Biochemical and biophysical research communications 20051209

• Thirty years of microbial P450 monooxygenase research: peroxo-heme intermediates--the central bus station in heme oxygenase catalysis.

  Biochemical and biophysical research communications 20051209

• Freeze-quenched iron-oxo intermediates in cytochromes P450.

  Biochemical and biophysical research communications 20051209

• A kinetic study of the mechanism of conversion of alpha-hydroxyheme to verdoheme while bound to heme oxygenase.

  Biochemical and biophysical research communications 20051209

• Rieske business: structure-function of Rieske non-heme oxygenases.

  Biochemical and biophysical research communications 20051209

• Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase.

  Brain research. Molecular brain research 20051207

• Self-hydroxylation of perbenzoic acids at a nonheme iron(II) center.

  Chemical communications (Cambridge, England) 20051207

• Temperature-dependent studies of NO recombination to heme and heme proteins.

  Journal of the American Chemical Society 20051207

• Suppression of the pro-apoptotic function of cytochrome c by singlet oxygen via a haem redox state-independent mechanism.

  The Biochemical journal 20051201

• Mosaic origin of the heme biosynthesis pathway in photosynthetic eukaryotes.

  Molecular biology and evolution 20051201

• Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species.

  Toxicology 20051201

• Studies on nitrosyl hemes in Ni(II)-Fe(II) hybrid hemoglobins.

  Nitric oxide : biology and chemistry 20051201

• Reorganization and conformational changes in the reduction of tetraheme cytochromes.

  Biophysical journal 20051201

• A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases.

  EMBO reports 20051201

• Enhancing the stability of microsomal cytochrome b5: a rational approach informed by comparative studies with the outer mitochondrial membrane isoform.

  Protein engineering, design & selection : PEDS 20051201

• Iron Imports. II. Iron uptake at the apical membrane in the intestine.

  American journal of physiology. Gastrointestinal and liver physiology 20051201

• Increase in heme oxygenase-1 levels ameliorates renovascular hypertension.

  Kidney international 20051201

• Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051201

• Allosteric modulation of anti-HIV drug and ferric heme binding to human serum albumin.

  The FEBS journal 20051201

• Enzymes of the heme biosynthetic pathway in the nonphotosynthetic alga Polytomella sp.

  Eukaryotic cell 20051201

• Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group.

  Chemical research in toxicology 20051201

• Carbon monoxide: endogenous production, physiological functions, and pharmacological applications.

  Pharmacological reviews 20051201

• Role of heme types in heme-copper oxidases: effects of replacing a heme b with a heme o mimic in an engineered heme-copper center in myoglobin.

  Journal of the American Chemical Society 20051130

• The challenge of being straight: explaining the linearity of a low-spin [FeNO]7 unit in a tropocoronand complex.

  Inorganic chemistry 20051128

• C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase.

  The Journal of biological chemistry 20051125

• Heme release in myoglobin-DDAB films and its role in electrochemical NO reduction.

  Journal of the American Chemical Society 20051123

• Heme iron, zinc and upper digestive tract cancer: the Iowa Women's Health Study.

  International journal of cancer 20051120

• Superoxide-dependent oxidation of melatonin by myeloperoxidase.

  The Journal of biological chemistry 20051118

• The position 68(E11) side chain in myoglobin regulates ligand capture, bond formation with heme iron, and internal movement into the xenon cavities.

  The Journal of biological chemistry 20051118

• Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires.

  Journal of the American Chemical Society 20051116

• Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH.

  The Biochemical journal 20051115

• Metabolism of pentacarboxylate porphyrinogens by highly purified human coproporphyrinogen oxidase: further evidence for the existence of an abnormal pathway for heme biosynthesis.

  Bioorganic & medicinal chemistry 20051115

• Picosecond structural dynamics of myoglobin following photodissociation of carbon monoxide as revealed by ultraviolet time-resolved resonance Raman spectroscopy.

  Biochemistry 20051115

• A role for the protein in internal electron transfer to the catalytic center of cytochrome c oxidase.

  Biochemistry 20051115

• Heme axial methionine fluxion in Pseudomonas aeruginosa Asn64Gln cytochrome c551.

  Inorganic chemistry 20051114

• A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem.

  Journal of molecular biology 20051111

• Excited state property of hardly photodissociable heme-CO adduct studied by time-dependent density functional theory.

  The journal of physical chemistry. B 20051110

• Why isn't 'standard' heme good enough for c-type and d1-type cytochromes?

  Dalton transactions (Cambridge, England : 2003) 20051107

• Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases.

  Dalton transactions (Cambridge, England : 2003) 20051107

• Cryoreduction EPR and 13C, 19F ENDOR study of substrate-bound substates and solvent kinetic isotope effects in the catalytic cycle of cytochrome P450cam and its T252A mutant.

  Dalton transactions (Cambridge, England : 2003) 20051107

• QM/MM studies of the electronic structure of the compound I intermediate in cytochrome c peroxidase and ascorbate peroxidase.

  Dalton transactions (Cambridge, England : 2003) 20051107

• Geminate carbon monoxide rebinding to a c-type haem.

  Dalton transactions (Cambridge, England : 2003) 20051107

• High pressure enhances hexacoordination in neuroglobin and other globins.

  The Journal of biological chemistry 20051104

• O(2)- and H(2)O(2)-dependent verdoheme degradation by heme oxygenase: reaction mechanisms and potential physiological roles of the dual pathway degradation.

  The Journal of biological chemistry 20051104

• Functional characterization of the C-terminal domain of the cytochrome c maturation protein CcmE.

  The Journal of biological chemistry 20051104

• Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants.

  The Journal of biological chemistry 20051104

• Detection of the His-heme Fe2+-NO species in the reduction of NO to N2O by ba3-oxidase from thermus thermophilus.

  Journal of the American Chemical Society 20051102

• Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051101

• Novel mutation of the CYP17 gene in two unrelated patients with combined 17alpha-hydroxylase/17,20-lyase deficiency: demonstration of absent enzyme activity by expressing the mutant CYP17 gene and by three-dimensional modeling.

  The Journal of steroid biochemistry and molecular biology 20051101

• A new sensitive assay reveals that hemoglobin is oxidatively modified in vivo.

  Free radical biology & medicine 20051101

• Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study.

  Biochemistry 20051101

• Redox and spectroscopic properties of human indoleamine 2,3-dioxygenase and a His303Ala variant: implications for catalysis.

  Biochemistry 20051101

• Cimetidine and acute intermittent porphyria.

  Annals of internal medicine 20051101

• Identification of a novel two-component system SenS/SenR modulating the production of the catalase-peroxidase CpeB and the haem-binding protein HbpS in Streptomyces reticuli.

  Microbiology (Reading, England) 20051101

• The importance of dietary composition for efficacy of iron absorption measured in a whole diet that includes rye bread fortified with ferrous fumerate: a radioisotope study in young women.

  The British journal of nutrition 20051101

• Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency.

  Biological chemistry 20051101

• Toward modeling H-NOX domains: a DFT study of heme-NO complexes as hydrogen bond acceptors.

  Inorganic chemistry 20051031

• FTIR difference spectra of Wolinella succinogenes quinol:fumarate reductase support a key role of Glu C180 within the 'E-pathway hypothesis' of coupled transmembrane electron and proton transfer.

  Biochemistry 20051025

• Characterization of the oxidase activity in mammalian catalase.

  The Journal of biological chemistry 20051021

• Heme carbonyls: environmental effects on nu(C-O) and Fe-C/C-O bond length correlations.

  Journal of the American Chemical Society 20051019

• Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin.

  Biochemistry 20051011

• Midpoint potentials of hemes a and a3 in the quinol oxidase from Acidianus ambivalens are inverted.

  Journal of the American Chemical Society 20051005

• The source of endogenous carbon monoxide formation in human placental chorionic villi.

  Cellular and molecular biology (Noisy-le-Grand, France) 20051003

• Monitoring circulatory heme level in hemin therapy for lowering blood pressure in rats.

  Cellular and molecular biology (Noisy-le-Grand, France) 20051003

• Induction of mitochondrial oxidative stress in astrocytes by nitric oxide precedes disruption of energy metabolism.

  Journal of neurochemistry 20051001

• Proximal effects in the modulation of nitric oxide synthase reactivity: a QM-MM study.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20051001

• Axial ligation and polypeptide matrix effects on the reduction potential of heme proteins probed on their cyanide adducts.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20051001

• Upregulation of alpha globin promotes apoptotic cell death in the hematopoietic cell line FL5.12.

  Apoptosis : an international journal on programmed cell death 20051001

• Structure and coordination of CuB in the Acidianus ambivalens aa3 quinol oxidase heme-copper center.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20051001

• Coverage-dependent changes of cytochrome c transverse location in phospholipid membranes revealed by FRET.

  Biochimica et biophysica acta 20051001

• Absolute configuration of the hydroxyfarnesylethyl group of haem A, determined by X-ray structural analysis of bovine heart cytochrome c oxidase using methods applicable at 2.8 Angstrom resolution.

  Acta crystallographica. Section D, Biological crystallography 20051001

• Fast track to the porphyrias.

  Nature medicine 20051001

• Mg-protoporphyrin IX and heme control HEMA, the gene encoding the first specific step of tetrapyrrole biosynthesis, in Chlamydomonas reinhardtii.

  Eukaryotic cell 20051001

• Spectroscopic characterization of the iron-oxo intermediate in cytochrome P450.

  Biological chemistry 20051001

• Electron transfer within complex II. Succinate:ubiquinone oxidoreductase of Escherichia coli.

  The Journal of biological chemistry 20050930

• Structural and functional changes in heart mitochondria from sucrose-fed hypertriglyceridemic rats.

  Biochimica et biophysica acta 20050930

• Heme oxygenase-1 transduction in endothelial cells causes downregulation of monocyte chemoattractant protein-1 and of genes involved in inflammation and growth.

  Cellular and molecular biology (Noisy-le-Grand, France) 20050930

• Ultrahigh resolution structures of nitrophorin 4: heme distortion in ferrous CO and NO complexes.

  Biochemistry 20050927

• Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans.

  The EMBO journal 20050921

• Site-directed modifications indicate differences in axial haem c iron ligation between the related NrfH and NapC families of multihaem c-type cytochromes.

  The Biochemical journal 20050915

• An improved colorimetric method for quantitation of heme using tetramethylbenzidine as substrate.

  Analytical biochemistry 20050915

• Photosystem II assembly in CP47 mutant of Synechocystis sp. PCC 6803 is dependent on the level of chlorophyll precursors regulated by ferrochelatase.

  The Journal of biological chemistry 20050909

• Peroxidase activity of the hemeoctapeptide N-acetylmicroperoxidase-8.

  Inorganic chemistry 20050905

• Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin.

  Blood 20050901

• Effects of nitroglycerin/L-cysteine on soluble guanylate cyclase: evidence for an activation/inactivation equilibrium controlled by nitric oxide binding and haem oxidation.

  The Biochemical journal 20050901

• Heme impairs allosterically drug binding to human serum albumin Sudlow's site I.

  Biochemical and biophysical research communications 20050826

• PGC-1alpha: looking behind the sweet treat for porphyria.

  Cell 20050826

• Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.

  Cell 20050826

• Mapping antimalarial pharmacophores as a useful tool for the rapid discovery of drugs effective in vivo: design, construction, characterization, and pharmacology of metaquine.

  Journal of medicinal chemistry 20050825

• Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis.

  Nature 20050825

• Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern.

  Journal of molecular biology 20050819

• Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.

  Nature 20050818

• Candida yeast long chain fatty alcohol oxidase is a c-type haemoprotein and plays an important role in long chain fatty acid metabolism.

  Biochimica et biophysica acta 20050815

• Mechanism of arsenite-mediated decreases in CYP3A23 in rat hepatocytes.

  Biochemical and biophysical research communications 20050812

• An arginine to lysine mutation in the vicinity of the heme propionates affects the redox potentials of the hemes and associated electron and proton transfer in cytochrome c oxidase.

  Biochemistry 20050809

• The protonation state of a heme propionate controls electron transfer in cytochrome c oxidase.

  Biochemistry 20050809

• Water chain formation and possible proton pumping routes in Rhodobacter sphaeroides cytochrome c oxidase: a molecular dynamics comparison of the wild type and R481K mutant.

  Biochemistry 20050809

• Binding dynamics at the quinone reduction (Qi) site influence the equilibrium interactions of the iron sulfur protein and hydroquinone oxidation (Qo) site of the cytochrome bc1 complex.

  Biochemistry 20050809

• Structural and dynamic properties of cytochrome P450 BM-3 in pure water and in a dimethylsulfoxide/water mixture.

  Biopolymers 20050805

• High-valent nonheme iron. Two distinct iron(IV) species derived from a common iron(II) precursor.

  Journal of the American Chemical Society 20050803

• Water-assisted oxo mechanism for heme metabolism.

  Journal of the American Chemical Society 20050803

• Heme reduction by intramolecular electron transfer in cysteine mutant myoglobin under carbon monoxide atmosphere.

  Biochemistry 20050802

• Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.

  Drug metabolism and disposition: the biological fate of chemicals 20050801

• Purification and characterization of succinate:menaquinone oxidoreductase from Corynebacterium glutamicum.

  Archives of microbiology 20050801

• Sterol uptake in Candida glabrata: rescue of sterol auxotrophic strains.

  Diagnostic microbiology and infectious disease 20050801

• Effects of repeated administration with CP-55,940, a cannabinoid CB1 receptor agonist on the metabolism of the hepatic heme.

  The international journal of biochemistry & cell biology 20050801

• Structural and dynamic properties of Synechocystis sp. PCC 6803 Hb revealed by reconstitution with Zn-protoporphyrin IX.

  Journal of inorganic biochemistry 20050801

• Regulation of tetrapyrrole biosynthesis in higher plants.

  Biochemical Society transactions 20050801

• Covalent cofactor attachment to proteins: cytochrome c biogenesis.

  Biochemical Society transactions 20050801

• A study of the horseradish peroxidase catalytic site by FTIR spectroscopy.

  Biochemical Society transactions 20050801

• Tracing heme in a living cell: hemoglobin degradation and heme traffic in digest cells of the cattle tick Boophilus microplus.

  The Journal of experimental biology 20050801

• The highly conserved Glu149 and Tyr190 residues contribute to peroxynitrite-mediated nitrotyrosine formation and the catalytic activity of cytochrome P450 2B1.

  Chemical research in toxicology 20050801

• The ABC transporter Abcg2/Bcrp: role in hypoxia mediated survival.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20050801

• Cytochrome aa3 in facultatively aerobic and hyperthermophilic archaeon Pyrobaculum oguniense.

  Canadian journal of microbiology 20050801

• [Effect of aggregation extent of microperoxidase-8 on its interaction with La3+].

  Guang pu xue yu guang pu fen xi = Guang pu 20050801

• Quantitative calcium measurements in subcellular compartments of Plasmodium falciparum-infected erythrocytes.

  The Journal of biological chemistry 20050729

• The Drosophila nuclear receptor e75 contains heme and is gas responsive.

  Cell 20050729

• Bishistidyl heme hexacoordination, a key structural property in Drosophila melanogaster hemoglobin.

  The Journal of biological chemistry 20050722

• Defining the structural basis for assembly of a transmembrane cytochrome.

  Journal of molecular biology 20050722

• Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2.

  Molecular cell 20050722

• The histidine of the c-type cytochrome CXXCH haem-binding motif is essential for haem attachment by the Escherichia coli cytochrome c maturation (Ccm) apparatus.

  The Biochemical journal 20050715

• Y25S variant of Paracoccus pantotrophus cytochrome cd1 provides insight into anion binding by d1 heme and a rare example of a critical difference between solution and crystal structures.

  The Journal of biological chemistry 20050715

• Wolbachia genomes: insights into an intracellular lifestyle.

  Current biology : CB 20050712

• ENDOR investigation of the liganding environment of mixed-spin ferric cytochrome c'.

  Journal of the American Chemical Society 20050706

• Mechanistic insight into alcohol oxidation by high-valent iron-oxo complexes of heme and nonheme ligands.

  Angewandte Chemie (International ed. in English) 20050704

• Heme-reversible impairment of CYP2B1/2 induction in heme-depleted rat hepatocytes in primary culture: translational control by a hepatic alpha-subunit of the eukaryotic initiation factor kinase?

  The Journal of pharmacology and experimental therapeutics 20050701

• Local compressibilities of proteins: comparison of optical experiments and simulations for horse heart cytochrome-c.

  Biophysical journal 20050701

• Molecular dynamics simulation of sperm whale myoglobin: effects of mutations and trapped CO on the structure and dynamics of cavities.

  Biophysical journal 20050701

• Molecular basis of intramolecular electron transfer in sulfite-oxidizing enzymes is revealed by high resolution structure of a heterodimeric complex of the catalytic molybdopterin subunit and a c-type cytochrome subunit.

  The Journal of biological chemistry 20050701

• Structural determinants of factor IX(a) binding in nitrophorin 2, a lipocalin inhibitor of the intrinsic coagulation pathway.

  The Journal of biological chemistry 20050701

• Structure and redox properties of the haem centre in the C357M mutant of cytochrome P450cam.

  Chembiochem : a European journal of chemical biology 20050701

• Entamoeba histolytica: construction and applications of subgenomic databases.

  Experimental parasitology 20050701

• Development of a food frequency questionnaire module and databases for compounds in cooked and processed meats.

  Molecular nutrition & food research 20050701

• Re-colorization of museum specimens: a modification of Romhanyi's technique based on pyridine/nicotine hemochromogen reactions.

  Virchows Archiv : an international journal of pathology 20050701

• [Structure and mechanism of heme oxygenase].

  Seikagaku. The Journal of Japanese Biochemical Society 20050701

• Pork meat increases iron absorption from a 5-day fully controlled diet when compared to a vegetarian diet with similar vitamin C and phytic acid content.

  The British journal of nutrition 20050701

• The Chlamydomonas reinhardtii gtr gene encoding the tetrapyrrole biosynthetic enzyme glutamyl-trna reductase: structure of the gene and properties of the expressed enzyme.

  Plant molecular biology 20050701

• Ferric cycle activity and Alzheimer disease.

  Current neurovascular research 20050701

• Accessibility of the distal heme face, rather than Fe-His bond strength, determines the heme-nitrosyl coordination number of cytochromes c': evidence from spectroscopic studies.

  Biochemistry 20050621

• Rapid electron transfer between monomers when the cytochrome bc1 complex dimer is reduced through center N.

  The Journal of biological chemistry 20050617

• The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG): autocatalytic formation and effect on enzyme catalysis and spectroscopic properties.

  The Journal of biological chemistry 20050617

• Determination of carbon monoxide (CO) in rodent tissue: effect of heme administration and environmental CO exposure.

  Analytical biochemistry 20050615

• Heme deficiency suppresses the expression of key neuronal genes and causes neuronal cell death.

  Brain research. Molecular brain research 20050613

• Sulfoxidation mechanisms catalyzed by cytochrome P450 and horseradish peroxidase models: spin selection induced by the ligand.

  Biochemistry 20050607

• Redox potential of cytochrome c550 in the cyanobacterium Thermosynechococcus elongates.

  FEBS letters 20050606

• CO-dependent activity-controlling mechanism of heme-containing CO-sensor protein, neuronal PAS domain protein 2.

  The Journal of biological chemistry 20050603

• Synthesis and characterization of azole isoflavone inhibitors of aromatase.

  Bioorganic & medicinal chemistry 20050602

• Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem.

  Nature 20050602

• Electric-field-induced redox potential shifts of tetraheme cytochromes c3 immobilized on self-assembled monolayers: surface-enhanced resonance Raman spectroscopy and simulation studies.

  Biophysical journal 20050601

• The single chlorophyll a molecule in the cytochrome b6f complex: unusual optical properties protect the complex against singlet oxygen.

  Biophysical journal 20050601

• New AMBER force field parameters of heme iron for cytochrome P450s determined by quantum chemical calculations of simplified models.

  Journal of computational chemistry 20050601

• Computational studies on imidazole heme conformations.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20050601

• Internal dynamics and protein-matrix coupling in trehalose-coated proteins.

  Biochimica et biophysica acta 20050601

• Prevention of hemorrhagic shock-induced lung injury by heme arginate treatment in rats.

  Biochemical pharmacology 20050601

• A hierarchy of functionally important relaxations within myoglobin based on solvent effects, mutations and kinetic model.

  Biochimica et biophysica acta 20050601

• Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia.

  The Journal of clinical investigation 20050601

• Iron absorption from concentrated hemoglobin hydrolysate by rat.

  The Journal of nutritional biochemistry 20050601

• Electron transfer chain reaction of the extracellular flavocytochrome cellobiose dehydrogenase from the basidiomycete Phanerochaete chrysosporium.

  The FEBS journal 20050601

• Desferrioxamine inhibits production of cytotoxic heme to protein cross-linked myoglobin: a mechanism to protect against oxidative stress without iron chelation.

  Chemical research in toxicology 20050601

• Reaction of ferric cytochrome P450cam with peracids: kinetic characterization of intermediates on the reaction pathway.

  The Journal of biological chemistry 20050527

• Glutathione depletion and anaesthesia in mice alter heme and drug metabolising enzymes.

  Biochimica et biophysica acta 20050525

• Mechanism of horseradish peroxidase-catalyzed heme oxidation and polymerization (beta-hematin formation).

  Biochimica et biophysica acta 20050525

• Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.

  Journal of medicinal chemistry 20050519

• A biophysical investigation of recombinant hemoglobins with aromatic B10 mutations in the distal heme pockets.

  Biochemistry 20050517

• Structure of the complex between plastocyanin and cytochrome f from the cyanobacterium Nostoc sp. PCC 7119 as determined by paramagnetic NMR. The balance between electrostatic and hydrophobic interactions within the transient complex determines the relative orientation of the two proteins.

  The Journal of biological chemistry 20050513

• Sulfur dehydrogenase of Paracoccus pantotrophus: the heme-2 domain of the molybdoprotein cytochrome c complex is dispensable for catalytic activity.

  Biochemistry 20050510

• Two faces of a biomimetic non-heme HO-Fe(v)=O oxidant: olefin epoxidation versus cis-dihydroxylation.

  Angewandte Chemie (International ed. in English) 20050506

• Photoinduced carbon monoxide migration in a synthetic heme-copper complex.

  Journal of the American Chemical Society 20050504

• Insight into molecular stability and physiological properties of the diheme cytochrome CYC41 from the acidophilic bacterium Acidithiobacillus ferrooxidans.

  Biochemistry 20050503

• Role of the covalent glutamic acid 242-heme linkage in the formation and reactivity of redox intermediates of human myeloperoxidase.

  Biochemistry 20050503

• Redox-dependent structural changes in an engineered heme-copper center in myoglobin: insights into chloride binding to CuB in heme copper oxidases.

  Biochemistry 20050503

• Purification and biochemical characterization of a heme containing peroxidase from the human parasite P. falciparum.

  Protein expression and purification 20050501

• Solution 1H NMR study of the accommodation of the side chain of n-butyl-etiohemin-I incorporated into the active site of cyano-metmyoglobin.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20050501

• Heme-dependent rubber oxygenase RoxA of Xanthomonas sp. cleaves the carbon backbone of poly(cis-1,4-Isoprene) by a dioxygenase mechanism.

  Applied and environmental microbiology 20050501

• Electrochemical and spectroscopic investigations of immobilized de novo designed heme proteins on metal electrodes.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20050501

• The effect of replacing the axial methionine ligand with a lysine residue in cytochrome c-550 from Paracoccus versutus assessed by X-ray crystallography and unfolding.

  The FEBS journal 20050501

• Effects of Y132H and F145L substitutions on the activity, azole resistance and spectral properties of Candida albicans sterol 14-demethylase P450 (CYP51): a live example showing the selection of altered P450 through interaction with environmental compounds.

  Journal of biochemistry 20050501

• Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure.

  The Journal of biological chemistry 20050429

• Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli.

  The Journal of biological chemistry 20050429

• Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants.

  The Journal of biological chemistry 20050429

• Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells.

  The Journal of biological chemistry 20050429

• CO rebinding to protoheme: investigations of the proximal and distal contributions to the geminate rebinding barrier.

  Journal of the American Chemical Society 20050427

• Expression, mutagenesis, and characterization of recombinant low-potential cytochrome c550 of photosystem II.

  Biochemistry 20050426

• A recombinant diheme SoxAX cytochrome - implications for the relationship between EPR signals and modified heme-ligands.

  FEBS letters 20050425

• Insights into the structure and function of redox-active tyrosines from model compounds.

  The journal of physical chemistry. B 20050421

• Prosthetic heme modification during halide ion oxidation. Demonstration of chloride oxidation by horseradish peroxidase.

  Journal of the American Chemical Society 20050420

• Mechanistic studies on the binding of nitric oxide to a synthetic heme-thiolate complex relevant to cytochrome p450.

  Journal of the American Chemical Society 20050420

• Characterization of a large subunit catalase truncated by proteolytic cleavage.

  Biochemistry 20050419

• Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.

  European journal of pharmacology 20050418

• Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A.

  The Journal of biological chemistry 20050415

• Role of arginine 220 in the oxygen sensor FixL from Bradyrhizobium japonicum.

  The Journal of biological chemistry 20050415

• Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes.

  Archives of biochemistry and biophysics 20050415

• Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways.

  Archives of biochemistry and biophysics 20050415

• Major artifacts encountered in studying biological samples containing ferric protoporphyrin IX.

  Analytical biochemistry 20050415

• Control of the redox potential of Pseudomonas aeruginosa cytochrome c551 through the Fe-Met coordination bond strength and pKa of a buried heme propionic acid side chain.

  Biochemistry 20050412

• Axial coordination of carboxylate activates the non-heme FeIV=O unit.

  Angewandte Chemie (International ed. in English) 20050408

• Synthesis and reactivity studies of a manganese 'microperoxidase' containing b-type heme.

  Dalton transactions (Cambridge, England : 2003) 20050407

• Resonance Raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase.

  Journal of the American Chemical Society 20050406

• Multielectron redox chemistry of iron porphyrinogens.

  Journal of the American Chemical Society 20050406

• Suppression of axial methionine fluxion in Hydrogenobacter thermophilus Gln64Asn cytochrome c552.

  Biochemistry 20050405

• beta-Hematin (hemozoin) mediated decompostion of polyunsaturated fatty acids to 4-hydroxy-2-nonenal.

  Inorganic chemistry 20050404

• Photoinduced electron transfer between cytochrome c and a novel 1,4,5,8-naphthalenetetracarboxylic diimide with amphiphilic character.

  Journal of photochemistry and photobiology. B, Biology 20050404

• The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.

  The Journal of pharmacology and experimental therapeutics 20050401

• Biophysical and kinetic characterization of HemAT, an aerotaxis receptor from Bacillus subtilis.

  Biophysical journal 20050401

• Monooxygenation of an aromatic ring by F43W/H64D/V68I myoglobin mutant and hydrogen peroxide. Myoglobin mutants as a model for P450 hydroxylation chemistry.

  The Journal of biological chemistry 20050401

• Proteomics of Shewanella oneidensis MR-1 biofilm reveals differentially expressed proteins, including AggA and RibB.

  Proteomics 20050401

• Haem conformation of amphibian nytrosylhaemoglobins detected by XANES spectroscopy.

  The European physical journal. E, Soft matter 20050401

• The effects of ligand exchange and mobility on the peroxidase activity of a bacterial cytochrome c upon unfolding.

  Chembiochem : a European journal of chemical biology 20050401

• Heme alkylation by artesunic acid and trioxaquine DU1301, two antimalarial trioxanes.

  Chembiochem : a European journal of chemical biology 20050401

• Aquisition, mobilization and utilization of cellular iron and heme: endless findings and growing evidence of tight regulation.

  The Tohoku journal of experimental medicine 20050401

• The influence of substrate on the spectral properties of oxyferrous wild-type and T252A cytochrome P450-CAM.

  Archives of biochemistry and biophysics 20050401

• Functional characterization and purification of a Saccharomyces cerevisiae ADP/ATP carrier-iso 1 cytochrome c fusion protein.

  Protein expression and purification 20050401

• Purification and characterization of bovine adrenal cytochrome b561 expressed in insect and yeast cell systems.

  Protein expression and purification 20050401

• Binding of gaseous Fe(III)-heme cation to model biological molecules: direct association and ligand transfer reactions.

  Journal of the American Society for Mass Spectrometry 20050401

• Hepatic gene expression in protoporphyic Fech mice is associated with cholestatic injury but not a marked depletion of the heme regulatory pool.

  The American journal of pathology 20050401

• Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum.

  The FEBS journal 20050401

• Heme oxygenase-1-generated biliverdin ameliorates experimental murine colitis.

  Inflammatory bowel diseases 20050401

• Ligand specificity of H-NOX domains: from sGC to bacterial NO sensors.

  Journal of inorganic biochemistry 20050401

• Invertebrate hemoglobins and nitric oxide: how heme pocket structure controls reactivity.

  Journal of inorganic biochemistry 20050401

• Insights into heme-based O2 sensing from structure-function relationships in the FixL proteins.

  Journal of inorganic biochemistry 20050401

• Respiration metabolism of Group B Streptococcus is activated by environmental haem and quinone and contributes to virulence.

  Molecular microbiology 20050401

• Acute intermittent porphyria.

  Best practice & research. Clinical gastroenterology 20050401

• Direct electrochemistry of heme multicofactor-containing enzymes on alkanethiol-modified gold electrodes.

  Bioelectrochemistry (Amsterdam, Netherlands) 20050401

• Toward selectivity control of a heme peptide electrode by modification with a phase-transition polymer.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050401

• Oral aspects of porphyria.

  International dental journal 20050401

• Expression of Nox genes in rat organs, mouse oocytes, and sea urchin eggs.

  DNA sequence : the journal of DNA sequencing and mapping 20050401

• Heme oxygenase overexpression attenuates glucose-mediated oxidative stress in quiescent cell phase: linking heme to hyperglycemia complications.

  Current neurovascular research 20050401

• S-Nitrosation and regulation of inducible nitric oxide synthase.

  Biochemistry 20050329

• A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.

  Biochemistry 20050329

• Unusual heme-histidine bond in the active site of a chaperone.

  Journal of the American Chemical Society 20050323

• Ligand, cofactor, and residue vibrations in the catalytic site of endothelial nitric oxide synthase.

  Biochemistry 20050322

• Proton interactions with hemes a and a3 in bovine heart cytochrome c oxidase.

  Biochemistry 20050322

• Cytochrome b6 arginine 214 of Synechococcus sp. PCC 7002, a key residue for quinone-reductase site function and turnover of the cytochrome bf complex.

  The Journal of biological chemistry 20050318

• Heme/non-heme diiron(II) complexes and O2, CO, and NO adducts as reduced and substrate-bound models for the active site of bacterial nitric oxide reductase.

  Journal of the American Chemical Society 20050316

• P450 active site architecture and reversibility: inactivation of cytochromes P450 2B4 and 2B4 T302A by tert-butyl acetylenes.

  Biochemistry 20050315

• Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domain.

  Biochemistry 20050315

• The P450cam G248E mutant covalently binds its prosthetic heme group.

  Biochemistry 20050315

• Tyrosine B10 and heme-ligand interactions of Lucina pectinata hemoglobin II: control of heme reactivity.

  Biochimica et biophysica acta 20050314

• Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis.

  The Journal of biological chemistry 20050311

• The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation.

  The Journal of biological chemistry 20050311

• Dioxygen reactivity of copper and heme-copper complexes possessing an imidazole-phenol cross-link.

  Inorganic chemistry 20050307

• NMR analysis of the transient complex between membrane photosystem I and soluble cytochrome c6.

  The Journal of biological chemistry 20050304

• Two heme binding sites are involved in the regulated degradation of the bacterial iron response regulator (Irr) protein.

  The Journal of biological chemistry 20050304

• Effect of altered iron metabolism on markers of haem biosynthesis and intestinal iron absorption in mice.

  Annals of hematology 20050301

• Examination of mitochondrial protein targeting of haem synthetic enzymes: in vivo identification of three functional haem-responsive motifs in 5-aminolaevulinate synthase.

  The Biochemical journal 20050301

• Characterization of a novel microperoxidase from Marinobacter hydrocarbonoclasticus by electrospray ionization tandem mass spectrometry.

  Journal of mass spectrometry : JMS 20050301

• A comparative reactivity study of microperoxidases based on hemin, mesohemin and deuterohemin.

  Journal of inorganic biochemistry 20050301

• Cobalt protoporphyrin protects against hepatic parenchymal injury and microvascular dysfunction during experimental rhabdomyolysis.

  Shock (Augusta, Ga.) 20050301

• The intrinsic axial ligand effect on propene oxidation by horseradish peroxidase versus cytochrome P450 enzymes.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20050301

• ED presentation of acute porphyria.

  The American journal of emergency medicine 20050301

• Dynamic cytoplasmic anchoring of the transcription factor Bach1 by intracellular hyaluronic acid binding protein IHABP.

  Journal of biochemistry 20050301

• Direct electrochemistry of hemoglobin in dimethyldioctadecyl ammonium bromide film and its electrocatalysis to nitric oxide.

  Journal of biochemical and biophysical methods 20050227

• Reaction of haem containing proteins and enzymes with hydroperoxides: the radical view.

  Biochimica et biophysica acta 20050225

• Molecular dynamics assignment of NMR correlation times to specific motions in a 'basket-handle porphyrin' heme.

  The journal of physical chemistry. B 20050224

• Quantum chemical evaluation of protein control over heme ligation: CO/O2 discrimination in myoglobin.

  The journal of physical chemistry. B 20050224

• Rapid freeze-quench 57Fe Mössbauer spectroscopy: monitoring changes of an iron-containing active site during a biochemical reaction.

  Inorganic chemistry 20050221

• Cytochrome c-crown ether complexes as supramolecular catalysts: cold-active synzymes for asymmetric sulfoxide oxidation in methanol.

  Inorganic chemistry 20050221

• Regulation of aldoxime dehydratase activity by redox-dependent change in the coordination structure of the aldoxime-heme complex.

  The Journal of biological chemistry 20050218

• Successful recombinant production of Allochromatium vinosum cytochrome c' requires coexpression of cmm genes in heme-rich Escherichia coli JCB712.

  Biochemical and biophysical research communications 20050218

• Metal ion binding to human hemopexin.

  Biochemistry 20050215

• Formation of a misfolded conformation during refolding of HRPA1 in the presence of calcium.

  Biochimica et biophysica acta 20050214

• An alternatively-spliced exon in the 5'-UTR of human ALAS1 mRNA inhibits translation and renders it resistant to haem-mediated decay.

  FEBS letters 20050214

• Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S center.

  The Journal of biological chemistry 20050211

• Down-regulation of iron regulatory protein 1 activities and expression in superoxide dismutase 1 knock-out mice is not associated with alterations in iron metabolism.

  The Journal of biological chemistry 20050211

• Endoproteolytic cleavage of human thyroperoxidase: role of the propeptide in the protein folding process.

  The Journal of biological chemistry 20050211

• Effects of heme on the structure of the denatured state and folding kinetics of cytochrome b562.

  Journal of molecular biology 20050211

• Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor.

  Journal of the American Chemical Society 20050209

• Energetics and structural consequences of axial ligand coordination in nonplanar nickel porphyrins.

  Journal of the American Chemical Society 20050202

• Heme oxygenase-1-mediated partial cytoprotective effect by NO on cadmium-induced cytotoxicity in C6 rat glioma cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20050201

• Abolition of oxygenase function, retention of NADPH oxidase activity, and emergence of peroxidase activity upon replacement of the axial cysteine-436 ligand by histidine in cytochrome P450 2B4.

  Archives of biochemistry and biophysics 20050201

• Heterologous expression of hexaheme fragments of a multidomain cytochrome from Geobacter sulfurreducens representing a novel class of cytochromes c.

  Protein expression and purification 20050201

• Effects of metal ions in the CuB center on the redox properties of heme in heme-copper oxidases: spectroelectrochemical studies of an engineered heme-copper center in myoglobin.

  Biochemistry 20050201

• The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria.

  Biochemistry 20050201

• Protein expressed by the ho2 gene of the cyanobacterium Synechocystis sp. PCC 6803 is a true heme oxygenase. Properties of the heme and enzyme complex.

  The FEBS journal 20050201

• Functional and structural analysis of catalase oxidized by singlet oxygen.

  Biochimie 20050201

• Regiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant.

  The Journal of biological chemistry 20050128

• Roles of distal Asp in heme oxygenase from Corynebacterium diphtheriae, HmuO: A water-driven oxygen activation mechanism.

  The Journal of biological chemistry 20050128

• Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification.

  Journal of the American Chemical Society 20050126

• Resonance Raman evidence for the presence of two heme pocket conformations with varied activities in CO-bound bovine soluble guanylate cyclase and their conversion.

  Biochemistry 20050125

• Laser photoinitiated nitrosylation of 3-electron reduced Nm europaea hydroxylamine oxidoreductase: kinetic and thermodynamic properties of the nitrosylated enzyme.

  Inorganic chemistry 20050124

• Reaction of artemisinin with haemoglobin: implications for antimalarial activity.

  The Biochemical journal 20050115

• Thermodynamic and kinetic analysis of the nitrosyl, carbonyl, and dioxy heme complexes of neuronal nitric-oxide synthase. The roles of substrate and tetrahydrobiopterin in oxygen activation.

  The Journal of biological chemistry 20050114

• Identification and characterization of a novel vitamin B12 (cobalamin) biosynthetic enzyme (CobZ) from Rhodobacter capsulatus, containing flavin, heme, and Fe-S cofactors.

  The Journal of biological chemistry 20050114

• The origin of stark splitting in the initial photoproduct state of MbCO.

  Journal of the American Chemical Society 20050112

• Unusual ligand discrimination by a myoglobin reconstituted with a hydrophobic domain-linked heme.

  Journal of the American Chemical Society 20050112

• Conversion of the Escherichia coli cytochrome b562 to an archetype cytochrome b: a mutant with bis-histidine ligation of heme iron.

  Biochemistry 20050111

• A molecular dynamics study of water chain formation in the proton-conducting K channel of cytochrome c oxidase.

  Biochimica et biophysica acta 20050107

• Intracellular kinetics of iron in reticulocytes: evidence for endosome involvement in iron targeting to mitochondria.

  Blood 20050101

• Bilirubin from heme oxygenase-1 attenuates vascular endothelial activation and dysfunction.

  Arteriosclerosis, thrombosis, and vascular biology 20050101

• Differential gene expression in rat colon by dietary heme and calcium.

  Carcinogenesis 20050101

• Cytoplasmic membrane iron permease systems in the bacterial cell envelope.

  Frontiers in bioscience : a journal and virtual library 20050101

• Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein.

  Archives of biochemistry and biophysics 20050101

• Heme-copper/dioxygen adduct formation relevant to cytochrome c oxidase: spectroscopic characterization of [(6L)FeIII-(O2(2-))-CuII]+.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20050101

• Understanding the unexpected linearity of the trans-{Mn(NO)2}8 unit in a phthalocyanine complex: some thoughts on dinitrosylheme intermediates in biology.

  Journal of inorganic biochemistry 20050101

• Nuclear resonance vibrational spectroscopy--NRVS.

  Journal of inorganic biochemistry 20050101

• Nitric oxide reductases of prokaryotes with emphasis on the respiratory, heme-copper oxidase type.

  Journal of inorganic biochemistry 20050101

• Nitric oxide interaction with insect nitrophorins and thoughts on the electron configuration of the {FeNO}6 complex.

  Journal of inorganic biochemistry 20050101

• Ligand-protein interactions in nitric oxide synthase.

  Journal of inorganic biochemistry 20050101

• Studies on heme release from normal and metal ion reconstituted hemoglobin mediated through ionic surfactant.

  Biopolymers 20050101

• Tobacco Mg protoporphyrin IX methyltransferase is involved in inverse activation of Mg porphyrin and protoheme synthesis.

  The Plant journal : for cell and molecular biology 20050101

• An analysis of 112 acute porphyric attacks in Cape Town, South Africa: Evidence that acute intermittent porphyria and variegate porphyria differ in susceptibility and severity.

  Medicine 20050101

• Functional implications of pigments bound to a cyanobacterial cytochrome b6f complex.

  The FEBS journal 20050101

• Intracellular redistribution of heme in rat liver under oxidative stress: the role of heme synthesis.

  Cell biology international 20050101

• Oxidative reactions of normal and abnormal hemoglobins in the presence of phosphatidylserine vesicles.

  Hemoglobin 20050101

• The role of charge distribution on the antimalarial activity of artemisinin analogues.

  Journal of chemical information and modeling 20050101

• Du-zhong (Eucommia ulmoides Oliv.) cortex water extract alters heme biosynthesis and erythrocyte antioxidant defense system in lead-administered rats.

  Journal of medicinal food 20050101

• The role of cystathionine beta-synthase in homocysteine metabolism.

  Antioxidants & redox signaling 20050101

• [Lead: indicators of dose and effects on heme].

  Giornale italiano di medicina del lavoro ed ergonomia 20050101

• Hemoglobins with high oxygen affinity leading to erythrocytosis. New variants and new concepts.

  Hemoglobin 20050101

• Probing the stability and structure of metalloporphyrin complexes with basic peptides by mass spectrometry.

  European journal of mass spectrometry (Chichester, England) 20050101

• Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging.

  Molecular aspects of medicine 20050101

• Interaction among heme iron, zinc, and supplemental vitamin C intake on the risk of lung cancer: Iowa Women's Health Study.

  Nutrition and cancer 20050101

• Xanthones as antimalarial agents: discovery, mode of action, and optimization.

  Current medicinal chemistry 20050101

• Cytochrome c superstructure biocomposite nucleated by gold nanoparticle: thermal stability and voltammetric behavior.

  Biomacromolecules 20050101

• Molecular orientation of porphyrins accompanying the formation of chain-aligned DNA films.

  Biomacromolecules 20050101

• Albumin clusters: structurally defined protein tetramer and oxygen carrier including thirty-two iron(II) porphyrins.

  Biomacromolecules 20050101

• Soluble guanylyl cyclase: the nitric oxide receptor.

  Methods in enzymology 20050101

• Purification and characterization of NO-sensitive guanylyl cyclase.

  Methods in enzymology 20050101

• Band 3/complement-mediated recognition and removal of normally senescent and pathological human erythrocytes.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20050101

• Neurovisceral porphyrias: what a hematologist needs to know.

  Hematology. American Society of Hematology. Education Program 20050101

• Hemoglobin and myoglobin associated oxidative stress: from molecular mechanisms to disease States.

  Current medicinal chemistry 20050101

• Complex kinetics of the electron transfer between the photoactive redox label TUPS and the heme of cytochrome c.

  Journal of chemical information and modeling 20050101

• [Primary prophylaxis of cerebrovascular complications in patients with metabolic syndrome].

  Terapevticheskii arkhiv 20050101

• Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia.

  Annals of the New York Academy of Sciences 20050101

• [Change in hemoproteid metabolism and its importance in the development of disorders of detoxication processes in patients with iron-deficiency anemia].

  Likars'ka sprava 20050101

• Mechanisms for vasoconstriction and decreased blood flow following intravenous administration of cell-free native hemoglobin solutions.

  Advances in experimental medicine and biology 20050101

• Free heme pool and activity of key enzyme of heme synthesis in the rat liver under action of agents affecting reduced glutathione level.

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20050101

• Structural and functional characterization of novel G-quadruplexed DNA-heme coordination complex.

  Nucleic acids symposium series (2004) 20050101

• Characterization of the high-spin heme x in the cytochrome b6f complex of oxygenic photosynthesis.

  Biochemistry 20041228

• Photochemical organic oxidations and dechlorinations with a mu-oxo bridged heme/non-heme diiron complex.

  Inorganic chemistry 20041227

• Reduction of the ferrous alpha-verdoheme-cytochrome b5 complex.

  Inorganic chemistry 20041227

• Arginine 391 in subunit I of the cytochrome bd quinol oxidase from Escherichia coli stabilizes the reduced form of the hemes and is essential for quinol oxidase activity.

  The Journal of biological chemistry 20041224

• Effect of axial coordination on the kinetics of assembly and folding of the two halves of horse heart cytochrome C.

  The Journal of biological chemistry 20041217

• Cytochrome c550 in the cyanobacterium Thermosynechococcus elongatus: study of redox mutants.

  The Journal of biological chemistry 20041217

• Role of Tyr-288 at the dioxygen reduction site of cytochrome bo studied by stable isotope labeling and resonance raman spectroscopy.

  The Journal of biological chemistry 20041217

• Cell biology. Oxygen sensing: it's a gas!

  Science (New York, N.Y.) 20041217

• Autocatalytic formation of green heme: evidence for H2O2-dependent formation of a covalent methionine-heme linkage in ascorbate peroxidase.

  Journal of the American Chemical Society 20041215

• Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS.

  The Journal of biological chemistry 20041210

• The interaction of covalently bound heme with the cytochrome c maturation protein CcmE.

  The Journal of biological chemistry 20041210

• Molecular modeling and small angle X-ray scattering studies of Hoplosternum littorale cathodic haemoglobin.

  Biochemical and biophysical research communications 20041210

• Dynamics of hemoglobin in human erythrocytes and in solution: influence of viscosity studied by ultrafast vibrational echo experiments.

  Journal of the American Chemical Society 20041208

• Modified microperoxidases exhibit different reactivity towards phenolic substrates.

  Chembiochem : a European journal of chemical biology 20041203

• Redox behaviour of the haem domain of flavocytochrome c3 from Shewanella frigidimarina probed by NMR.

  FEBS letters 20041203

• Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days.

  The Journal of pharmacology and experimental therapeutics 20041201

• Heme transport exhibits polarity in Caco-2 cells: evidence for an active and membrane protein-mediated process.

  American journal of physiology. Gastrointestinal and liver physiology 20041201

• Calculated coupling of transmembrane electron and proton transfer in dihemic quinol:fumarate reductase.

  Biophysical journal 20041201

• Short-term inhibitory effects of nitric oxide on cytochrome P450-mediated drug metabolism: time dependency and reversibility profiles in isolated perfused rat livers.

  Drug metabolism and disposition: the biological fate of chemicals 20041201

• The 40s Omega-loop plays a critical role in the stability and the alkaline conformational transition of cytochrome c.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20041201

• A proteomic analysis of thioacetamide-induced hepatotoxicity and cirrhosis in rat livers.

  Proteomics 20041201

• Carbon monoxide actuates O(2)-limited heme degradation in the rat brain.

  Free radical biology & medicine 20041201

• Hemoglobin-binding protein HgbA in the outer membrane of Actinobacillus pleuropneumoniae: homology modelling reveals regions of potential interactions with hemoglobin and heme.

  Journal of molecular graphics & modelling 20041201

• Heme degradation by reactive oxygen species.

  Antioxidants & redox signaling 20041201

• Siderophore and haem iron use by Tritrichomonas foetus.

  Microbiology (Reading, England) 20041201

• Concurrent interactions of heme and FLU with Glu tRNA reductase (HEMA1), the target of metabolic feedback inhibition of tetrapyrrole biosynthesis, in dark- and light-grown Arabidopsis plants.

  The Plant journal : for cell and molecular biology 20041201

• The heme iron coordination of unfolded ferric and ferrous cytochrome c in neutral and acidic urea solutions. Spectroscopic and electrochemical studies.

  Biochimica et biophysica acta 20041201

• [Activity of heme synthesis enzymes in the bone marrow cells of rats with alimentary iron-deficient anemia].

  Likars'ka sprava 20041201

• Iron availability: An updated review.

  International journal of food sciences and nutrition 20041201

• Oxidative verdoheme formation and stabilization by axial isocyanide ligation.

  Inorganic chemistry 20041129

• Femtomolar sensitivity of a NO sensor from Clostridium botulinum.

  Science (New York, N.Y.) 20041126

• The redox behavior of the heme in cystathionine beta-synthase is sensitive to pH.

  Biochemistry 20041123

• Semihemoglobins, high oxygen affinity dimeric forms of human hemoglobin respond efficiently to allosteric effectors without forming tetramers.

  The Journal of biological chemistry 20041119

• 4-cyanopyridine, a versatile spectroscopic probe for cytochrome P450 BM3.

  The Journal of biological chemistry 20041119

• Steric effects of isoleucine 107 on heme reorientation reaction in human myoglobin.

  Biochemical and biophysical research communications 20041119

• ATR-FTIR spectroscopy and isotope labeling of the PM intermediate of Paracoccus denitrificans cytochrome c oxidase.

  Biochemistry 20041116

• An effective chromatographic separation of chicken red blood cell coproporphyrinogen oxidase and uroporphyrinogen decarboxylase, two enzymes in heme biosynthesis.

  Bioorganic & medicinal chemistry letters 20041115

• Protein microarray system for detecting protein-protein interactions using an anti-His-tag antibody and fluorescence scanning: effects of the heme redox state on protein-protein interactions of heme-regulated phosphodiesterase from Escherichia coli.

  Analytical chemistry 20041115

• Field-flow fractionation of cells with chemiluminescence detection.

  Journal of chromatography. A 20041112

• NO activation of guanylyl cyclase.

  The EMBO journal 20041110

• Dioxygenation of human serum albumin having a prosthetic heme group in a tailor-made heme pocket.

  Journal of the American Chemical Society 20041110

• NO binding and dynamics in reduced heme-copper oxidases aa3 from Paracoccus denitrificans and ba3 from Thermus thermophilus.

  Biochemistry 20041109

• Investigation of the role of the N-terminal proline, the distal heme ligand in the CO sensor CooA.

  Biochemistry 20041109

• In situ effects of mutations of the extrinsic cytochrome c550 of photosystem II in Synechocystis sp. PCC6803.

  Biochemistry 20041109

• SOUL in mouse eyes is a new hexameric heme-binding protein with characteristic optical absorption, resonance Raman spectral, and heme-binding properties.

  Biochemistry 20041109

• Synthesis of protoheme IX derivatives with a covalently linked proximal base and their human serum albumin hybrids as artificial hemoprotein.

  Organic & biomolecular chemistry 20041107

• The C-helix in CooA rolls upon CO binding to ferrous heme.

  The Journal of biological chemistry 20041105

• Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells.

  Biochemical and biophysical research communications 20041105

• Consumption of nitric oxide by endothelial cells: evidence for the involvement of a NAD(P)H-, flavin- and heme-dependent dioxygenase reaction.

  FEBS letters 20041105

• Photodissociation of heme distal methionine in ferrous cytochrome C revealed by subpicosecond time-resolved resonance Raman spectroscopy.

  Journal of the American Chemical Society 20041103

• Modulation of the folding energy landscape of cytochrome C with salt.

  Journal of the American Chemical Society 20041103

• Crystal structures of ferrous and ferrous-NO forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage.

  Journal of inorganic biochemistry 20041101

• Models and mechanisms of O-O bond activation by cytochrome P450. A critical assessment of the potential role of multiple active intermediates in oxidative catalysis.

  European journal of biochemistry 20041101

• Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme.

  European journal of biochemistry 20041101

• Methyl phenyl selenide causes heme biosynthesis impairment and its toxicity is not modified by dimethyl sulphoxide in vivo.

  Drug and chemical toxicology 20041101

• The heme oxygenase(s)-phytochrome system of Pseudomonas aeruginosa.

  The Journal of biological chemistry 20041029

• Identification of a heme-sensing domain in iron regulatory protein 2.

  The Journal of biological chemistry 20041029

• Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase.

  The Journal of biological chemistry 20041029

• Changing the ligand specificity of CooA, a highly specific heme-based CO sensor.

  The Journal of biological chemistry 20041029

• Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase.

  Biochemistry 20041019

• Upstream stimulatory factors, USF1 and USF2, bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription.

  The Biochemical journal 20041015

• Effects of systematic peripheral group deuteration on the low-frequency resonance Raman spectra of myoglobin derivatives.

  Biopolymers 20041015

• Hydroxyl radical oxidation of cytochrome c by aerobic radiolysis.

  Free radical biology & medicine 20041015

• Direct electron transfer to the oxygenase domain of neuronal nitric oxide synthase (NOS): exploring unique redox properties of NOS enzymes.

  Journal of the American Chemical Society 20041013

• Oxidation of carboxylic acids by horseradish peroxidase results in prosthetic heme modification and inactivation.

  Journal of the American Chemical Society 20041013

• L358P mutation on cytochrome P450cam simulates structural changes upon putidaredoxin binding: the structural changes trigger electron transfer to oxy-P450cam from electron donors.

  The Journal of biological chemistry 20041008

• Human heme oxygenase oxidation of 5- and 15-phenylhemes.

  The Journal of biological chemistry 20041008

• Cyanide binding to hexacoordinate cyanobacterial hemoglobins: hydrogen-bonding network and heme pocket rearrangement in ferric H117A Synechocystis hemoglobin.

  Biochemistry 20041005

• Reactions of meso-hydroxyhemes with carbon monoxide and reducing agents in search of the elusive species responsible for the g = 2.006 resonance of carbon monoxide-treated heme oxygenase. Isolation of diamagnetic iron(II) complexes of octaethyl-meso-hydroxyporphyrin.

  Inorganic chemistry 20041004

• Identification of amino acid residues involved in the inactivation of cytochrome P450 2B1 by two acetylenic compounds: the role of three residues in nonsubstrate recognition Sites.

  The Journal of pharmacology and experimental therapeutics 20041001

• Ubiquitination and degradation of neuronal nitric-oxide synthase in vitro: dimer stabilization protects the enzyme from proteolysis.

  Molecular pharmacology 20041001

• Purification and spectropotentiometric characterization of Escherichia coli NrfB, a decaheme homodimer that transfers electrons to the decaheme periplasmic nitrite reductase complex.

  The Journal of biological chemistry 20041001

• Structure and function of the Gondwanian hemoglobin of Pseudaphritis urvillii, a primitive notothenioid fish of temperate latitudes.

  Protein science : a publication of the Protein Society 20041001

• Characterization of a heme oxygenase of Clostridium tetani and its possible role in oxygen tolerance.

  Archives of microbiology 20041001

• Why heme needs to be degraded to iron, biliverdin IXalpha, and carbon monoxide?

  Antioxidants & redox signaling 20041001

• Heme oxygenase and its products in the nervous system.

  Antioxidants & redox signaling 20041001

• Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase.

  Protein expression and purification 20041001

• Octaheme tetrathionate reductase is a respiratory enzyme with novel heme ligation.

  Nature structural & molecular biology 20041001

• Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control.

  European journal of biochemistry 20041001

• Refractory status epilepticus due to acute hepatic porphyria in a pregnant woman: induced abortion as the sole therapeutic option?

  European journal of neurology 20041001

• Candida albicans lacking the frataxin homologue: a relevant yeast model for studying the role of frataxin.

  Molecular microbiology 20041001

• Interaction of oxaliplatin, cisplatin, and carboplatin with hemoglobin and the resulting release of a heme group.

  Chemical research in toxicology 20041001

• Bis-histidyl hexacoordination in hemoglobins facilitates heme reduction kinetics.

  Journal of the American Chemical Society 20040929

• Cytochrome rC552, formed during expression of the truncated, Thermus thermophilus cytochrome c552 gene in the cytoplasm of Escherichia coli, reacts spontaneously to form protein-bound 2-formyl-4-vinyl (Spirographis) heme.

  Biochemistry 20040928

• A relationship between heme binding and protein stability in cytochrome b5.

  Biochemistry 20040928

• Regulation of hem gene expression in Rhodobacter capsulatus by redox and photosystem regulators RegA, CrtJ, FnrL, and AerR.

  Journal of molecular biology 20040924

• Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin.

  FEBS letters 20040924

• Reconstruction and functional characterization of the human mitochondrial metabolic network based on proteomic and biochemical data.

  The Journal of biological chemistry 20040917

• Unusual Cys-Tyr covalent bond in a large catalase.

  Journal of molecular biology 20040917

• Identification of a human heme exporter that is essential for erythropoiesis.

  Cell 20040917

• Nitric oxide-induced modification of protein thiolate clusters as determined by spectral fluorescence resonance energy transfer in live endothelial cells.

  Free radical biology & medicine 20040915

• Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae.

  The Journal of biological chemistry 20040910

• Crystal structure of Mycobacterium tuberculosis catalase-peroxidase.

  The Journal of biological chemistry 20040910

• Enzyme-catalyzed mechanism of isoniazid activation in class I and class III peroxidases.

  The Journal of biological chemistry 20040910

• Viscosity-dependent relaxation significantly modulates the kinetics of CO recombination in the truncated hemoglobin TrHbN from Mycobacterium tuberculosis.

  The Journal of biological chemistry 20040910

• The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution.

  The Journal of biological chemistry 20040910

• Role of H164 in a unique dye-decolorizing heme peroxidase DyP.

  Biochemical and biophysical research communications 20040910

• A site-selective dual anchoring strategy for artificial metalloprotein design.

  Journal of the American Chemical Society 20040908

• Purification and biochemical characterization of simplified eukaryotic nitrate reductase expressed in Pichia pastoris.

  Protein expression and purification 20040901

• The catalase activity of Nalpha-acetyl-microperoxidase-8.

  The journal of peptide research : official journal of the American Peptide Society 20040901

• Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3.

  Journal of inorganic biochemistry 20040901

• Stability of the heme environment of the nitric oxide synthase from Staphylococcus aureus in the absence of pterin cofactor.

  Biophysical journal 20040901

• Non-thermal effects of electromagnetic fields at mobile phone frequency on the refolding of an intracellular protein: myoglobin.

  Journal of cellular biochemistry 20040901

• Hydroperoxoferric heme intermediate as a second electrophilic oxidant in cytochrome P450-catalyzed reactions.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20040901

• Mechanism of in vitro heme-induced LDL oxidation: effects of antioxidants.

  European journal of clinical investigation 20040901

• Roles of noncoordinated aromatic residues in redox regulation of cytochrome c3 from Desulfovibrio vulgaris Miyazaki F.

  Biochemistry 20040831

• Investigations of photolysis and rebinding kinetics in myoglobin using proximal ligand replacements.

  Biochemistry 20040831

• The role of the length and sequence of the linker domain of cytochrome b5 in stimulating cytochrome P450 2B4 catalysis.

  The Journal of biological chemistry 20040827

• The function of the small insertion in the hinge subdomain in the control of constitutive mammalian nitric-oxide synthases.

  The Journal of biological chemistry 20040827

• Compound 800, a natural product isolated from genetically engineered Pseudomonas: proposed structure, reactivity, and putative relation to heme d1.

  Biochemistry 20040824

• Ancestral gene fusion in cellobiose dehydrogenases reflects a specific evolution of GMC oxidoreductases in fungi.

  Gene 20040818

• S-Nitrosohemoglobin: an allosteric mediator of NO group function in mammalian vasculature.

  Free radical biology & medicine 20040815

• Identification of key elements that are responsible for heme-mediated induction of the avian heme oxygenase-1 gene.

  Biochimica et biophysica acta 20040812

• 1H NMR characterization of the solution active site structure of substrate-bound, cyanide-inhibited heme oxygenase from Neisseria meningitidis: comparison to crystal structures.

  Biochemistry 20040810

• Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from Vibrio cholerae and Thermoanaerobacter tengcongensis.

  Biochemistry 20040810

• De novo design, synthesis, and function of semiartificial myoglobin conjugated with coiled-coil two-alpha-helix peptides.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20040806

• Design and synthesis of de novo cytochromes c.

  Biochemistry 20040803

• Redox characterization of Geobacter sulfurreducens cytochrome c7: physiological relevance of the conserved residue F15 probed by site-specific mutagenesis.

  Biochemistry 20040803

• Homology modeling of lanosterol 14alpha-demethylase of Candida albicans and Aspergillus fumigatus and insights into the enzyme-substrate Interactions.

  Journal of biomolecular structure & dynamics 20040801

• Electrocatalytic oxidation of ascorbate by heme-FeIII/heme-FeII redox couple of the HRP and its effect on the electrochemical behaviour of an L-lactate biosensor.

  Bioelectrochemistry (Amsterdam, Netherlands) 20040801

• Heme inhibits human neutrophil apoptosis: involvement of phosphoinositide 3-kinase, MAPK, and NF-kappaB.

  Journal of immunology (Baltimore, Md. : 1950) 20040801

• The three-dimensional structure of catalase from Enterococcus faecalis.

  Acta crystallographica. Section D, Biological crystallography 20040801

• The comparative study on the solution structures of the oxidized bovine microsomal cytochrome b5 and mutant V45H.

  Protein science : a publication of the Protein Society 20040801

• Characterization of noncovalent complexes of antimalarial agents of the artemisinin-type and FE(III)-heme by electrospray mass spectrometry and collisional activation tandem mass spectrometry.

  Journal of the American Society for Mass Spectrometry 20040801

• Temperature control of a 3,4-dihydroxybenzoate (protocatechuate)-based siderophore in Bacillus anthracis.

  Current microbiology 20040801

• Isolation and transcriptional regulation of the Kluyveromyces lactis FBA1 (fructose-1,6-bisphosphate aldolase) gene.

  Canadian journal of microbiology 20040801

• Role of the heme regulatory motif in the heme-mediated inhibition of mitochondrial import of 5-aminolevulinate synthase.

  Journal of biochemistry 20040801

• A comparative study of O2, CO and CN binding to heme IX protein models.

  Molecules (Basel, Switzerland) 20040731

• Refolding processes of cytochrome P450cam from ferric and ferrous acid forms to the native conformation. Formations of folding intermediates with non-native heme coordination state.

  The Journal of biological chemistry 20040730

• Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin.

  The Journal of biological chemistry 20040730

• Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.

  Science (New York, N.Y.) 20040730

• The quinone chemistry of bc complexes.

  Biochimica et biophysica acta 20040723

• Heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo.

  Circulation 20040720

• NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum.

  The Journal of biological chemistry 20040716

• The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase.

  The Journal of biological chemistry 20040716

• Hemoglobin site-mutants reveal dynamical role of interhelical H-bonds in the allosteric pathway: time-resolved UV resonance Raman evidence for intra-dimer coupling.

  Journal of molecular biology 20040716

• Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base.

  Archives of biochemistry and biophysics 20040715

• Thiocyanate catalyzes myeloperoxidase-initiated lipid oxidation in LDL.

  Free radical biology & medicine 20040715

• Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue.

  Nature 20040715

• Heme A synthase does not incorporate molecular oxygen into the formyl group of heme A.

  Biochemistry 20040713

• Crystal structure of the ascorbate peroxidase-salicylhydroxamic acid complex.

  Biochemistry 20040713

• Characterization of the heme environment in Arabidopsis thaliana fatty acid alpha-dioxygenase-1.

  The Journal of biological chemistry 20040709

• Heme deficiency causes apoptosis but does not increase ROS generation in HeLa cells.

  Biochemical and biophysical research communications 20040709

• Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1.

  The EMBO journal 20040707

• Heme structures of five variants of hemoglobin M probed by resonance Raman spectroscopy.

  Biochemistry 20040706

• Design and characterisation of an artificial DNA-binding cytochrome.

  Chembiochem : a European journal of chemical biology 20040705

• Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability.

  The Journal of biological chemistry 20040702

• The sulphur oxygenase reductase from Acidianus ambivalens is a multimeric protein containing a low-potential mononuclear non-haem iron centre.

  The Biochemical journal 20040701

• The structure of murine neuroglobin: Novel pathways for ligand migration and binding.

  Proteins 20040701

• Inactivation of Plasmodium falciparum by photodynamic excitation of heme-cycle intermediates derived from delta-aminolevulinic acid.

  The Journal of infectious diseases 20040701

• Structure and direct electrochemistry of cytochrome P450 from the thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain 7.

  Journal of inorganic biochemistry 20040701

• Analysis of the kinetics of CO binding to neuronal nitric oxide synthase by flash photolysis: dual effects of substrates, inhibitors, and tetrahydrobiopterin.

  Journal of inorganic biochemistry 20040701

• CO exchange of the oxyferrous complexes of endothelial nitric-oxide synthase oxygenase domain in the presence of 4-amino-tetrahydrobiopterin.

  Journal of inorganic biochemistry 20040701

• Synthesis and solid-state molecular structures of nitrosoalkane complexes of iron porphyrins containing methanol, pyridine, and 1-methylimidazole ligands.

  Journal of inorganic biochemistry 20040701

• Heme, iron, and the mitochondrial decay of ageing.

  Ageing research reviews 20040701

• [Structure and function of the cytochrome b6f complex of oxygenic photosynthesis].

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20040701

• Meat and meat products consumption in Italy: contribution to trace elements, heme iron and selected B vitamins supply.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20040701

• Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions.

  Biochemistry 20040629

• Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding.

  The Journal of biological chemistry 20040625

• Heme distortion modulated by ligand-protein interactions in inducible nitric-oxide synthase.

  The Journal of biological chemistry 20040618

• Structural and functional characterization of the unusual triheme cytochrome bound to the reaction center of Rhodovulum sulfidophilum.

  The Journal of biological chemistry 20040618

• Heme environment in aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis.

  FEBS letters 20040618

• Paclitaxel-HSA interaction. Binding sites on HSA molecule.

  Bioorganic & medicinal chemistry 20040615

• Electron-transfer chemistry of Ru-linker-(heme)-modified myoglobin: rapid intraprotein reduction of a photogenerated porphyrin cation radical.

  Inorganic chemistry 20040614

• Structural basis of human cytoglobin for ligand binding.

  Journal of molecular biology 20040611

• Oxygen binding and oxidation reactions of human hemoglobin conjugated to carboxylate dextran.

  Biochimica et biophysica acta 20040611

• Mechanistic studies of the isomerization of peroxynitrite to nitrate catalyzed by distal histidine metmyoglobin mutants.

  Journal of the American Chemical Society 20040609

• Proximal and distal influences on ligand binding kinetics in microperoxidase and heme model compounds.

  Biochemistry 20040608

• Effector-mediated alteration of substrate orientation in cytochrome P450 2C9.

  Biochemistry 20040608

• Horseradish peroxidase mutants that autocatalytically modify their prosthetic heme group: insights into mammalian peroxidase heme-protein covalent bonds.

  The Journal of biological chemistry 20040604

• The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.

  The Journal of biological chemistry 20040604

• A medicinal chemistry perspective on artemisinin and related endoperoxides.

  Journal of medicinal chemistry 20040603

• Preparation and reactivity studies of synthetic microperoxidases containing b-type heme.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20040601

• Spectroelectrochemical study of heme- and molybdopterin cofactor-containing chicken liver sulphite oxidase.

  Bioelectrochemistry (Amsterdam, Netherlands) 20040601

• Redox reactions of hemoglobin.

  Antioxidants & redox signaling 20040601

• Structure of a novel c7-type three-heme cytochrome domain from a multidomain cytochrome c polymer.

  Protein science : a publication of the Protein Society 20040601

• Theoretical study of the ligand-CYP2B4 complexes: effect of structure on binding free energies and heme spin state.

  Proteins 20040601

• A model for the misfolded bis-His intermediate of cytochrome c: the 1-56 N-fragment.

  Journal of inorganic biochemistry 20040601

• Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases.

  Drug metabolism and disposition: the biological fate of chemicals 20040601

• An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.

  Biochemistry 20040601

• Protective role of heme oxygenase in the blood vessel wall during atherogenesis.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20040601

• Evidence for two different electron transfer pathways in the same enzyme, nitrate reductase A from Escherichia coli.

  European journal of biochemistry 20040601

• Unusual heme iron-lipid acyl chain coordination in Escherichia coli flavohemoglobin.

  Biophysical journal 20040601

• A novel Arabidopsis thaliana protein is a functional peripheral-type benzodiazepine receptor.

  Plant & cell physiology 20040601

• Delaying the mitochondrial decay of aging.

  Annals of the New York Academy of Sciences 20040601

• Structural basis for the mechanism of Ca(2+) activation of the di-heme cytochrome c peroxidase from Pseudomonas nautica 617.

  Structure (London, England : 1993) 20040601

• High-throughput non-heme iron assay for animal tissues.

  Journal of biochemical and biophysical methods 20040531

• A single mutation in cytochrome P450 BM3 induces the conformational rearrangement seen upon substrate binding in the wild-type enzyme.

  The Journal of biological chemistry 20040528

• Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set.

  The Journal of biological chemistry 20040528

• Formation of a highly oxidized iron biliverdin complex upon treatment of a five-coordinate verdoheme with dioxygen.

  Journal of the American Chemical Society 20040526

• The effects of axial ligands on electron distribution and spin states in iron complexes of octaethyloxophlorin, intermediates in heme degradation.

  Journal of the American Chemical Society 20040526

• Conformational substates of the oxyheme centers in alpha and beta subunits of hemoglobin as disclosed by EPR and ENDOR studies of cryoreduced protein.

  Biochemistry 20040525

• Conformational properties of the iso-1-cytochrome C denatured state: dependence on guanidine hydrochloride concentration.

  Journal of molecular biology 20040521

• Role of the conserved arginine pair in proton and electron transfer in cytochrome C oxidase.

  Biochemistry 20040518

• Quantitative determination of heme for forensic characterization of bacillus spores using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

  Analytical chemistry 20040515

• Heme-ligand tunneling in group I truncated hemoglobins.

  The Journal of biological chemistry 20040514

• Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.

  Biochemistry 20040511

• Mixed regioselectivity in the Arg-177 mutants of Corynebacterium diphtheriae heme oxygenase as a consequence of in-plane heme disorder.

  Biochemistry 20040511

• Conversion of the 2,2,6,6-tetramethylpiperidine moiety to a 2,2-dimethylpyrrolidine by cytochrome P450: evidence for a mechanism involving nitroxide radicals and heme iron.

  Biochemistry 20040511

• Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium.

  Biochemistry 20040511

• A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor.

  The Journal of biological chemistry 20040507

• Evidence of two distinct oxygen complexes of reduced endothelial nitric oxide synthase.

  The Journal of biological chemistry 20040507

• Paracoccus pantotrophus NapC can reductively activate cytochrome cd1 nitrite reductase.

  FEBS letters 20040507

• Determination of the nature of the heme environment in nitrosyl indoleamine 2,3-dioxygenase using Multiple-scattering analyses of X-ray absorption fine structure.

  Biochemistry 20040504

• pH Dependence of heme iron coordination, hydrogen peroxide reactivity, and cyanide binding in cytochrome c peroxidase(H52K).

  Biochemistry 20040504

• Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells.

  Blood 20040501

• Heme-iron increases levels of AP65-mediated adherence by Trichomonas vaginalis.

  Microbial pathogenesis 20040501

• Influence of stereoisomer of dispiro-1,2,4,5-tetraoxanes on their binding mode with heme and on antimalarial activity: molecular docking studies.

  Bioorganic & medicinal chemistry 20040501

• The mechanism-based inactivation of p450 2B4 by tert-butyl 1-methyl-2-propynyl ether: structural determination of the adducts to the p450 heme.

  Archives of biochemistry and biophysics 20040501

• Expression of human heme oxygenase-1 in the thick ascending limb attenuates angiotensin II-mediated increase in oxidative injury.

  Kidney international 20040501

• Chronic arsenic poisoning in the rat: treatment with combined administration of succimers and an antioxidant.

  Ecotoxicology and environmental safety 20040501

• Crystallization and preliminary X-ray diffraction analysis of the 16-haem cytochrome of Desulfovibrio gigas.

  Acta crystallographica. Section D, Biological crystallography 20040501

• Noninvasive auto-photoreduction used as a tool for studying structural changes in heme-copper oxidases by FTIR spectroscopy.

  Biophysical journal 20040501

• Cryptic O2- -generating NADPH oxidase in dendritic cells.

  Journal of cell science 20040501

• On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation.

  Current medicinal chemistry. Anti-cancer agents 20040501

• Resonance Raman study on synergistic activation of soluble guanylate cyclase by imidazole, YC-1 and GTP.

  Journal of inorganic biochemistry 20040501

• Correct interpretation of heme protein spectra allows distinguishing between the heme and the protein dynamics.

  Biopolymers 20040501

• Manipulating the covalent link between distal side tryptophan, tyrosine, and methionine in catalase-peroxidases: an electronic absorption and resonance Raman study.

  Biopolymers 20040501

• pH dependence of heme electrochemistry in cytochromes investigated by multiconformation continuum electrostatic calculations.

  Biopolymers 20040501

• Involvement of a Glu71-Arg64 couple in the access channel for NADH in cytochrome p450nor.

  Bioscience, biotechnology, and biochemistry 20040501

• Functional characterization of the purified holo form of hemoglobin I from Lucina pectinata overexpressed in Escherichia coli.

  The protein journal 20040501

• Aminoacyl-tRNA synthesis by pre-translational amino acid modification.

  RNA biology 20040501

• Thermodynamics of oxidation-reduction reactions in mammalian nitric-oxide synthase isoforms.

  The Journal of biological chemistry 20040430

• A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis.

  The Journal of biological chemistry 20040430

• A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles.

  The Journal of biological chemistry 20040430

• Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis.

  The EMBO journal 20040421

• Heme ferrous-hydroperoxo complexes: some theoretical considerations.

  Archives of biochemistry and biophysics 20040415

• Structural change of the heme pocket due to disulfide bridge formation is significantly larger for neuroglobin than for cytoglobin.

  Journal of the American Chemical Society 20040414

• The use of stable isotopes and spectroscopy to investigate the energy transducing function of cytochrome c oxidase.

  Biochimica et biophysica acta 20040412

• UV optical absorption by protein radicals in cytochrome c oxidase.

  Biochimica et biophysica acta 20040412

• FTIR studies of internal proton transfer reactions linked to inter-heme electron transfer in bovine cytochrome c oxidase.

  Biochimica et biophysica acta 20040412

• NMR analysis shows that a b-type variant of Hydrogenobacter thermophilus cytochrome c552 retains its native structure.

  The Journal of biological chemistry 20040409

• How O2 binds to heme: reasons for rapid binding and spin inversion.

  The Journal of biological chemistry 20040409

• Anti-cooperative oxidation of ubiquinol by the yeast cytochrome bc1 complex.

  The Journal of biological chemistry 20040409

• The use of the novel substrate-heme complex approach in the derivation of a representation of the active site of the enzyme complex 17alpha-hydroxylase and 17,20-lyase.

  Biochemical and biophysical research communications 20040409

• Crystal structure of human heme oxygenase-1 in a complex with biliverdin.

  Biochemistry 20040406

• Haptoglobin phenotypes differ in their ability to inhibit heme transfer from hemoglobin to LDL.

  Biochemistry 20040406

• Biochemical and spectroscopic characterization of the covalent binding of heme to cytochrome b6.

  Biochemistry 20040406

• Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040401

• Heme as an optical probe of a conformational transition of ovine recPrP.

  Protein science : a publication of the Protein Society 20040401

• New activities of a catalytic antibody with a peroxidase activity: formation of Fe(II)-RNO complexes and stereoselective oxidation of sulfides.

  European journal of biochemistry 20040401

• Probing the Q-proton pathway of ba3-cytochrome c oxidase by time-resolved Fourier transform infrared spectroscopy.

  Biophysical journal 20040401

• Biology of heme in health and disease.

  Current medicinal chemistry 20040401

• The effects of inhibition of haem biosynthesis by griseofulvin on intestinal iron absorption.

  Basic & clinical pharmacology & toxicology 20040401

• The source of heme for vascular heme oxygenase I: heme uptake in rat aorta.

  Canadian journal of physiology and pharmacology 20040401

• The source of heme for vascular heme oxygenase II: de novo heme biosynthesis in rat aorta.

  Canadian journal of physiology and pharmacology 20040401

• Microanalysis of non-heme iron in animal tissues.

  Journal of biochemical and biophysical methods 20040331

• Protein radical formation during lactoperoxidase-mediated oxidation of the suicide substrate glutathione: immunochemical detection of a lactoperoxidase radical-derived 5,5-dimethyl-1-pyrroline N-oxide nitrone adduct.

  The Journal of biological chemistry 20040326

• Novel endoperoxide antimalarials: synthesis, heme binding, and antimalarial activity.

  Journal of medicinal chemistry 20040325

• Structure of Helicobacter pylori catalase, with and without formic acid bound, at 1.6 A resolution.

  Biochemistry 20040323

• The crystal structures of the ferric and ferrous forms of the heme complex of HmuO, a heme oxygenase of Corynebacterium diphtheriae.

  The Journal of biological chemistry 20040319

• Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues.

  The Journal of biological chemistry 20040319

• A catalysis-based selection for peroxidase antibodies with increased activity.

  Journal of the American Chemical Society 20040317

• Proton uptake upon anaerobic reduction of the Paracoccus denitrificans cytochrome c oxidase: a kinetic investigation of the K354M and D124N mutants.

  Biochemistry 20040316

• Lipid dynamics in yeast under haem-induced unsaturated fatty acid and/or sterol depletion.

  The Biochemical journal 20040315

• Protonation of two adjacent tyrosine residues influences the reduction of cytochrome c by diphenylacetaldehyde: a possible mechanism to select the reducer agent of heme iron.

  Free radical biology & medicine 20040315

• Characterization of the solution reactivity of a basic heme peroxidase from Cucumis sativus.

  Archives of biochemistry and biophysics 20040315

• Heme controls the expression of cell cycle regulators and cell growth in HeLa cells.

  Biochemical and biophysical research communications 20040312

• Identification of the heme axial ligands in the cytochrome b562 of the Saccharomyces cerevisiae succinate dehydrogenase.

  The Journal of biological chemistry 20040305

• An EPR, ESEEM, structural NMR, and DFT study of a synthetic model for the covalently ring-linked tyrosine-histidine structure in the heme-copper oxidases.

  Journal of the American Chemical Society 20040303

• Direct detection of formate ligation in cytochrome c oxidase by ATR-FTIR spectroscopy.

  Journal of the American Chemical Society 20040303

• Characterization of the heme-histidine cross-link in cyanobacterial hemoglobins from Synechocystis sp. PCC 6803 and Synechococcus sp. PCC 7002.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20040301

• Carbon monoxide in biology and medicine.

  BioEssays : news and reviews in molecular, cellular and developmental biology 20040301

• Enhancement of heme-induced membrane damage by the anti-malarial clotrimazole: the role of colloid-osmotic forces.

  Biological & pharmaceutical bulletin 20040301

• The occurrence of two types of hemopexin-like protein in medaka and differences in their affinity to heme.

  The Journal of experimental biology 20040301

• Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast.

  Nature reviews. Microbiology 20040301

• Enzymes for heme biosynthesis are found in both the mitochondrion and plastid of the malaria parasite Plasmodium falciparum.

  Protist 20040301

• Phe393 mutants of cytochrome P450 BM3 with modified heme redox potentials have altered heme vinyl and propionate conformations.

  Biochemistry 20040224

• Delta-aminolevulinic acid dehydratase from Plasmodium falciparum: indigenous versus imported.

  The Journal of biological chemistry 20040220

• Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase.

  The Journal of biological chemistry 20040220

• Mechanism of dioxygen activation in 2-oxoglutarate-dependent enzymes: a hybrid DFT study.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20040220

• A possible role for the covalent heme-protein linkage in cytochrome c revealed via comparison of N-acetylmicroperoxidase-8 and a synthetic, monohistidine-coordinated heme peptide.

  Biochemistry 20040217

• Myoglobin/sol-gel film modified electrode: direct electrochemistry and electrochemical catalysis.

  Langmuir : the ACS journal of surfaces and colloids 20040217

• Residues in the distal heme pocket of neuroglobin. Implications for the multiple ligand binding steps.

  The Journal of biological chemistry 20040213

• Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.

  The Journal of biological chemistry 20040213

• Reversible redox energy coupling in electron transfer chains.

  Nature 20040212

• Dynamic regulation of the inducible nitric-oxide synthase by NO: comparison with the endothelial isoform.

  The Journal of biological chemistry 20040206

• Hydrophobic effect of trityrosine on heme ligand exchange during folding of cytochrome c.

  Biochemical and biophysical research communications 20040206

• Mammalian mitochondrial and microsomal cytochromes b(5) exhibit divergent structural and biophysical characteristics.

  Biochemical and biophysical research communications 20040206

• Family of cytochrome c7-type proteins from Geobacter sulfurreducens: structure of one cytochrome c7 at 1.45 A resolution.

  Biochemistry 20040203

• Engineering peroxidase activity in myoglobin: the haem cavity structure and peroxide activation in the T67R/S92D mutant and its derivative reconstituted with protohaemin-l-histidine.

  The Biochemical journal 20040201

• Volatile anaesthetics induce biochemical alterations in the heme pathway in a B-lymphocyte cell line established from hepatoerythropoietic porphyria patients (LBHEP) and in mice inoculated with LBHEP cells.

  The international journal of biochemistry & cell biology 20040201

• The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis.

  The international journal of biochemistry & cell biology 20040201

• Hemoglobin hydrolysis and heme acquisition by Porphyromonas gingivalis.

  Oral microbiology and immunology 20040201

• Dietary iron intake and Type 2 diabetes incidence in postmenopausal women: the Iowa Women's Health Study.

  Diabetologia 20040201

• Spectrophotometric determination of de novo hemozoin/beta-hematin formation in an in vitro assay.

  Analytical biochemistry 20040201

• Identification of variable amino acids in the SRS1 region of CYP6B1 modulating furanocoumarin metabolism.

  Archives of biochemistry and biophysics 20040201

• Horseradish peroxidase: a modern view of a classic enzyme.

  Phytochemistry 20040201

• Models of the bis-histidine-ligated electron-transferring cytochromes. Comparative geometric and electronic structure of low-spin ferro- and ferrihemes.

  Chemical reviews 20040201

• Potential of peroxynitrite to promote the conversion of oxyhemoglobin to methemoglobin.

  Acta biochimica et biophysica Sinica 20040201

• Effect of gossypol in association with chromium protoporphyrin on heme metabolic enzymes.

  Artificial cells, blood substitutes, and immobilization biotechnology 20040201

• Structure of a cDNA for Ciona Cytochrome b(5) and the ubiquitous expression of mRNA in embryonic tissues.

  Journal of biochemistry 20040201

• Binding of oxygen and carbon monoxide to a heme-regulated phosphodiesterase from Escherichia coli. Kinetics and infrared spectra of the full-length wild-type enzyme, isolated PAS domain, and Met-95 mutants.

  The Journal of biological chemistry 20040130

• Heme oxygenase in Candida albicans is regulated by hemoglobin and is necessary for metabolism of exogenous heme and hemoglobin to alpha-biliverdin.

  The Journal of biological chemistry 20040130

• Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclase.

  The Journal of biological chemistry 20040123

• Hybridization of modified-heme reconstitution and distal histidine mutation to functionalize sperm whale myoglobin.

  Journal of the American Chemical Society 20040121

• Facile ring opening of iron(III) and iron(II) complexes of meso-amino-octaethylporphyrin by dioxygen.

  Journal of the American Chemical Society 20040121

• Mechanism of spinach chloroplast ferredoxin-dependent nitrite reductase: spectroscopic evidence for intermediate states.

  Biochemistry 20040120

• Proton NMR study of the heme environment in bacterial quinol oxidases.

  Archives of biochemistry and biophysics 20040115

• Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin.

  Biochemistry 20040113

• Folding of Aplysia limacina apomyoglobin involves an intermediate in common with other evolutionarily distant globins.

  Biochemistry 20040113

• The 2.0 A resolution crystal structure of prostaglandin H2 synthase-1: structural insights into an unusual peroxidase.

  Journal of molecular biology 20040109

• Formation and spectroscopic characterization of the dioxygen adduct of a heme-Cu complex possessing a cross-linked tyrosine-histidine mimic: modeling the active site of cytochrome c oxidase.

  Chemical communications (Cambridge, England) 20040107

• IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus.

  The Journal of biological chemistry 20040102

• Alkylation of human hemoglobin A0 by the antimalarial drug artemisinin.

  FEBS letters 20040102

• Properties of a novel periplasmic catalase-peroxidase from Escherichia coli O157:H7.

  Archives of biochemistry and biophysics 20040101

• Molecular basis for redox-Bohr and cooperative effects in cytochrome c3 from Desulfovibrio desulfuricans ATCC 27774: crystallographic and modeling studies of oxidized and reduced high-resolution structures at pH 7.6.

  Proteins 20040101

• Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha.

  Bioscience, biotechnology, and biochemistry 20040101

• Intake of dietary iron is low in patients with Crohn's disease: a case-control study.

  The British journal of nutrition 20040101

• HeLp, a heme-transporting lipoprotein with an antioxidant role.

  Insect biochemistry and molecular biology 20040101

• Properties of two distinct heme centers of cytochrome b561 from bovine chromaffin vesicles studied by EPR, resonance Raman, and ascorbate reduction assay.

  Journal of biochemistry 20040101

• Coupling of the heme and an internal disulfide bond in human neuroglobin.

  Micron (Oxford, England : 1993) 20040101

• Lysine-specific gingipain K and heme/hemoglobin receptor HmuR are involved in heme utilization in Porphyromonas gingivalis.

  Acta biochimica Polonica 20040101

• Mass spectrometric detection of protein, lipid and heme components of cytochrome c oxidase from R. sphaeroides and the stabilization of non-covalent complexes from the enzyme.

  European journal of mass spectrometry (Chichester, England) 20040101

• Identification of 42 possible cytochrome C genes in the Shewanella oneidensis genome and characterization of six soluble cytochromes.

  Omics : a journal of integrative biology 20040101

• Heme oxygenase system in ischemia and reperfusion injury.

  Annals of transplantation 20040101

• Interactions of two amphiphilic penicillins with myoglobin in aqueous buffered solutions: a thermodynamic and spectroscopy study.

  Biomacromolecules 20040101

• Guanylyl cyclase: NO hits its target.

  Biochemical Society symposium 20040101

• Activation of cytochrome c to a peroxidase compound I-type intermediate by H2O2: relevance to redox signalling in apoptosis.

  Biochemical Society symposium 20040101

• Reversible hexa- to penta-coordination of the heme Fe atom modulates ligand binding properties of neuroglobin and cytoglobin.

  IUBMB life 20040101

• Tracing the structure-function relationship of neuroglobin and cytoglobin using resonance Raman and electron paramagnetic resonance spectroscopy.

  IUBMB life 20040101

• Structure-function relationships in the growing hexa-coordinate hemoglobin sub-family.

  IUBMB life 20040101

• An iron-peroxo porphyrin complex: new synthesis and reactivity toward a Cu(II) complex giving a heme-peroxo-copper adduct.

  Journal of the American Chemical Society 20031231

• 1H NMR structural characterization of the cytochrome c modifications in a micellar environment.

  Biochemistry 20031230

• Dynamic features of a heme delivery system for cytochrome C maturation.

  The Journal of biological chemistry 20031226

• Reversal of cyanide inhibition of cytochrome c oxidase by the auxiliary substrate nitric oxide: an endogenous antidote to cyanide poisoning?

  The Journal of biological chemistry 20031226

• A cytochrome b562 variant with a c-type cytochrome CXXCH heme-binding motif as a probe of the Escherichia coli cytochrome c maturation system.

  The Journal of biological chemistry 20031226

• HYSCORE spectroscopy in the cytochrome b(559) of the photosystem II reaction center.

  Journal of the American Chemical Society 20031224

• Low-spin ferriheme models of the cytochromes: correlation of molecular structure with EPR spectral type.

  Journal of the American Chemical Society 20031224

• Time-resolved resonance Raman and time-resolved step-scan FTIR studies of nitric oxide reductase from Paracoccus denitrificans: comparison of the heme b3-FeB site to that of the heme-CuB in oxidases.

  Biochemistry 20031223

• Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species.

  The Journal of biological chemistry 20031212

• A mechanism of oxygen sensing in yeast. Multiple oxygen-responsive steps in the heme biosynthetic pathway affect Hap1 activity.

  The Journal of biological chemistry 20031212

• Overlapping specificities of the mitochondrial cytochrome c and c1 heme lyases.

  The Journal of biological chemistry 20031212

• Oxygen activation and electron transfer in flavocytochrome P450 BM3.

  Journal of the American Chemical Society 20031210

• Effects of site-directed mutations on heme reduction in Escherichia coli nitrate reductase A by menaquinol: a stopped-flow study.

  Biochemistry 20031209

• Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene.

  The Journal of biological chemistry 20031205

• Compressibility and uncoupling of cytochrome P450cam: high pressure FTIR and activity studies.

  Biochemical and biophysical research communications 20031205

• Ligand binding in a docking site of cytochrome C oxidase: a time-resolved step-scan Fourier transform infrared study.

  Journal of the American Chemical Society 20031203

• CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis.

  Nature structural biology 20031201

• Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery.

  Biochemical pharmacology 20031201

• Characterization of Met95 mutants of a heme-regulated phosphodiesterase from Escherichia coli. Optical absorption, magnetic circular dichroism, circular dichroism, and redox potentials.

  European journal of biochemistry 20031201

• Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics.

  Environmental microbiology 20031201

• Red blood cells upregulate cytoprotective proteins and the labile iron pool in dividing human T cells despite a reduction in oxidative stress.

  Free radical biology & medicine 20031201

• 1H-NMR study of dynamics and thermodynamics of Cl- binding to ferric hemoglobin of a midge larva (Tokunagayusurika akamusi).

  Biochimica et biophysica acta 20031201

• Structural studies of Proteus mirabilis catalase in its ground state, oxidized state and in complex with formic acid.

  Acta crystallographica. Section D, Biological crystallography 20031201

• Co-ordination of iron acquisition, iron porphyrin chelation and iron-protoporphyrin export via the cytochrome c biogenesis protein CcmC in Pseudomonas fluorescens.

  Microbiology (Reading, England) 20031201

• The distinct heme coordination environments and heme-binding stabilities of His39Ser and His39Cys mutants of cytochrome b5.

  Protein engineering 20031201

• Wolinella succinogenes quinol:fumarate reductase and its comparison to E. coli succinate:quinone reductase.

  FEBS letters 20031127

• An atypical haem in the cytochrome b(6)f complex.

  Nature 20031127

• Protein-based radicals in the catalase-peroxidase of synechocystis PCC6803: a multifrequency EPR investigation of wild-type and variants on the environment of the heme active site.

  Journal of the American Chemical Society 20031119

• Histidine 61: an important heme ligand in the soluble fumarate reductase from Shewanella frigidimarina.

  Biochemistry 20031118

• Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity.

  Biochemistry 20031118

• Accessibility of oxygen with respect to the heme pocket in horseradish peroxidase.

  Proteins 20031115

• Export of a heterologous cytochrome P450 (CYP105D1) in Escherichia coli is associated with periplasmic accumulation of uroporphyrin.

  The Journal of biological chemistry 20031114

• Histidine 386 and its role in cyclooxygenase and peroxidase catalysis by prostaglandin-endoperoxide H synthases.

  The Journal of biological chemistry 20031114

• Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK.

  The Journal of biological chemistry 20031107

• Rapid formation of compound II and a tyrosyl radical in the Y229F mutant of Mycobacterium tuberculosis catalase-peroxidase disrupts catalase but not peroxidase function.

  The Journal of biological chemistry 20031107

• Structure of the cytochrome b6f complex of oxygenic photosynthesis: tuning the cavity.

  Science (New York, N.Y.) 20031107

• Radiation-induced enhancement of nitrite reducing activity of cytochrome c.

  Journal of agricultural and food chemistry 20031105

• Kinetic stability of the peroxidase activity of unfolded cytochrome c: heme degradation and catalyst inactivation by hydrogen peroxide.

  Inorganic chemistry 20031103

• Mechanism of horseradish peroxidase inactivation by benzhydrazide: a critical evaluation of arylhydrazides as peroxidase inhibitors.

  The Biochemical journal 20031101

• Variation of the axial haem ligands and haem-binding motif as a probe of the Escherichia coli c-type cytochrome maturation (Ccm) system.

  The Biochemical journal 20031101

• Role of the aromatic ring of Tyr43 in tetraheme cytochrome c(3) from Desulfovibrio vulgaris Miyazaki F.

  Biophysical journal 20031101

• Let's Sco1, Oxidase! Let's Sco!

  Structure (London, England : 1993) 20031101

• Identification of rate-limiting steps in yeast heme biosynthesis.

  Biochemical and biophysical research communications 20031031

• Formation and isolation of an iron-tripyrrole complex from heme degradation.

  Journal of the American Chemical Society 20031022

• The regulatory effect of heme on erythroid aminolevulinate synthase in natural erythroid cells.

  Biochimica et biophysica acta 20031020

• A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions.

  The Journal of biological chemistry 20031017

• Nanosecond photoreduction of cytochrome p450cam by channel-specific Ru-diimine electron tunneling wires.

  Journal of the American Chemical Society 20031015

• Role of the non-respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae.

  Yeast (Chichester, England) 20031015

• NMR study on the structural changes of cytochrome P450cam upon the complex formation with putidaredoxin. Functional significance of the putidaredoxin-induced structural changes.

  The Journal of biological chemistry 20031010

• Modeling features of the non-heme diiron cores in O2-activating enzymes through the synthesis, characterization, and oxidation of 1,8-naphthyridine-based complexes.

  Inorganic chemistry 20031006

• Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesis.

  The Journal of biological chemistry 20031003

• Factors affecting the catalytic epoxidation of olefins by iron porphyrin complexes and H2O2 in protic solvents.

  The Journal of organic chemistry 20031003

• Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats.

  Carcinogenesis 20031001

• Effects of exogenous heme on renal function: role of heme oxygenase and cyclooxygenase.

  Hypertension (Dallas, Tex. : 1979) 20031001

• Synthesis of biotinylated heme and its application to panning heme-binding proteins.

  Analytical biochemistry 20031001

• Reversible binding of nitric oxide and carbon-carbon bond formation in a meso-hydroxylated heme.

  Journal of the American Chemical Society 20031001

• Mimicking photosynthesis in a computationally designed synthetic metalloprotein.

  Journal of the American Chemical Society 20031001

• The rate of O2 and CO binding to a copper complex, determined by a 'flash-and-trap' technique, exceeds that for hemes.

  Journal of the American Chemical Society 20031001

• Ligand delivery by haem carrier proteins: the binding of Serratia marcescens haemophore to its outer membrane receptor is mediated by two distinct peptide regions.

  Molecular microbiology 20031001

• CcpA regulation of aerobic and respiration growth in Lactococcus lactis.

  Molecular microbiology 20031001

• Solvent dependent and independent motions of CO-horseradish peroxidase examined by infrared spectroscopy and molecular dynamics calculations.

  Biophysical chemistry 20031001

• Mechanism-based inhibition of CYP activities in rat liver by fluoxetine and structurally similar alkylamines.

  Xenobiotica; the fate of foreign compounds in biological systems 20031001

• Electrochemical and electrocatalytic properties of myoglobin and hemoglobin incorporated in carboxymethyl cellulose films.

  Bioelectrochemistry (Amsterdam, Netherlands) 20031001

• 1H NMR studies of the effect of mutation at Valine45 on heme microenvironment of cytochrome b5.

  Biochimie 20031001

• Thermally induced stoichiometric and catalytic O-atom transfer by a non-heme iron(III)-nitro complex: first example of reversible [Fe-NO]7<-->FeIII-NO2 transformation in the presence of dioxygen.

  Angewandte Chemie (International ed. in English) 20030929

• Distinct influence of N-terminal elements on neuronal nitric-oxide synthase structure and catalysis.

  The Journal of biological chemistry 20030926

• Nonplanar distortions of bis-base low-spin iron(II)-porphyrinates: absorption and resonance Raman investigations of cross-trans-linked iron(II)-basket-handle porphyrin complexes.

  Journal of the American Chemical Society 20030924

• Chemical and kinetic reaction mechanisms of quinohemoprotein amine dehydrogenase from Paracoccus denitrificans.

  Biochemistry 20030923

• Absorption and resonance Raman investigations of ligand rotation and nonplanar heme distortion in bis-base low-spin iron(II)-tetrakis(o-pivalamidophenyl)porphyrin complexes.

  Inorganic chemistry 20030922

• Purification and characterization of the MQH2:NO oxidoreductase from the hyperthermophilic archaeon Pyrobaculum aerophilum.

  The Journal of biological chemistry 20030919

• Intra- and intermolecular transfers of protein radicals in the reactions of sperm whale myoglobin with hydrogen peroxide.

  The Journal of biological chemistry 20030919

• Temperature, pH, and solvent isotope dependent properties of the active sites of resting-state and cyanide-ligated recombinant cytochrome c peroxidase (H52L) revealed by proton hyperfine resonance spectra.

  Biochemistry 20030916

• The naphthoquinol oxidizing cytochrome bc1 complex of the hyperthermophilic knallgasbacterium Aquifex aeolicus: properties and phylogenetic relationships.

  Biochemistry 20030916

• Reductive activation of HCFC-123 by methaemalbumin.

  Toxicology letters 20030915

• Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity.

  Biochemical pharmacology 20030915

• Direct electron transfer of heme- and molybdopterin cofactor-containing chicken liver sulfite oxidase on alkanethiol-modified gold electrodes.

  Analytical chemistry 20030915

• Activation mechanism of the CO sensor CooA. Mutational and resonance Raman spectroscopic studies.

  The Journal of biological chemistry 20030912

• Flavohemoglobin Hmp, but not its individual domains, confers protection from respiratory inhibition by nitric oxide in Escherichia coli.

  The Journal of biological chemistry 20030912

• A pH-dependent aquomet-to-hemichrome transition in crystalline horse methemoglobin.

  Biochemistry 20030902

• Molecular engineering of myoglobin: influence of residue 68 on the rate and the enantioselectivity of oxidation reactions catalyzed by H64D/V68X myoglobin.

  Biochemistry 20030902

• Inversion of axial coordination in myoglobin to create a 'proximal' ligand binding pocket.

  Biochemistry 20030902

• Significance of beta116 His (G18) at alpha1beta1 contact sites for alphabeta assembly and autoxidation of hemoglobin.

  Biochemistry 20030902

• DNA-protein cross-linking via guanine oxidation: dependence upon protein and photosensitizer.

  Biochemistry 20030902

• An internal enhancer regulates heme- and cadmium-mediated induction of human heme oxygenase-1.

  American journal of physiology. Renal physiology 20030901

• Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase.

  Nature structural biology 20030901

• Preparation of heme-free soluble guanylate cyclase.

  Protein expression and purification 20030901

• Resonance Raman spectroscopy of cytochrome c peroxidase variants that mimic manganese peroxidase.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030901

• Overproduction of highly active trypanosome alternative oxidase in Escherichia coli heme-deficient mutant.

  Parasitology international 20030901

• Biophysical and structural analysis of a novel heme B iron ligation in the flavocytochrome cellobiose dehydrogenase.

  The Journal of biological chemistry 20030829

• Synthesis, characterization, and laser flash photolysis reactivity of a carbonmonoxy heme complex.

  Inorganic chemistry 20030825

• Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate. Conformational change of the distal helix during the heme cleavage reaction.

  The Journal of biological chemistry 20030822

• A novel double heme substitution produces a functional bo3 variant of the quinol oxidase aa3 of Bacillus cereus. Purification and paratial characterization.

  The Journal of biological chemistry 20030822

• Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane.

  Organic & biomolecular chemistry 20030821

• Redox-driven proton pumping by heme-copper oxidases.

  Biochimica et biophysica acta 20030818

• CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis.

  The Journal of biological chemistry 20030815

• An electrical potential in the access channel of catalases enhances catalysis.

  The Journal of biological chemistry 20030815

• EPR spectroscopy studies on the structural transition of nitrosyl hemoglobin in the arterial-venous cycle of DEANO-treated rats as it relates to the proposed nitrosyl hemoglobin/nitrosothiol hemoglobin exchange.

  Free radical biology & medicine 20030815

• Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding.

  Biochemistry 20030812

• A dramatic push effect on the homolysis of FeIII(OOR) intermediates to form non-heme FeIV=O complexes.

  Angewandte Chemie (International ed. in English) 20030811

• Evidence for the role of a peroxidase compound I-type intermediate in the oxidation of glutathione, NADH, ascorbate, and dichlorofluorescin by cytochrome c/H2O2. Implications for oxidative stress during apoptosis.

  The Journal of biological chemistry 20030808

• Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase.

  The Journal of biological chemistry 20030808

• Conservation in the CYP51 family. Role of the B' helix/BC loop and helices F and G in enzymatic function.

  Biochemistry 20030805

• 5-Aminolevulinic acid synthesis in epimastigotes of Trypanosoma cruzi.

  The international journal of biochemistry & cell biology 20030801

• Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic group.

  Archives of biochemistry and biophysics 20030801

• Protein engineering of thromboxane synthase: conversion of membrane-bound to soluble form.

  Archives of biochemistry and biophysics 20030801

• Leptospira spp. possess a complete haem biosynthetic pathway and are able to use exogenous haem sources.

  Molecular microbiology 20030801

• P450 on drugs.

  Nature structural biology 20030801

• The solution structure of the oxidized bovine microsomal cytochrome b(5) mutant V61H.

  Biochemical and biophysical research communications 20030801

• Metabolic control of the tetrapyrrole biosynthetic pathway for porphyrin distribution in the barley mutant albostrians.

  The Plant journal : for cell and molecular biology 20030801

• Heme oxygenase-1: unleashing the protective properties of heme.

  Trends in immunology 20030801

• Correction of the biochemical defect in porphobilinogen deaminase deficient cells by non-viral gene delivery.

  Molecular and cellular biochemistry 20030801

• Understanding functional diversity and substrate specificity in haem peroxidases: what can we learn from ascorbate peroxidase?

  Natural product reports 20030801

• An ubiquitin ligase recognizing a protein oxidized by iron: implications for the turnover of oxidatively damaged proteins.

  Journal of biochemistry 20030801

• Whey proteins protect more than red meat against azoxymethane induced ACF in Wistar rats.

  Cancer letters 20030730

• Compound I formation in artichoke (Cynara scolymus L.) peroxidase is modulated by the equilibrium between pentacoordinated and 6-aquo hexacoordinated forms of the heme and by calcium ions.

  Biochemistry 20030729

• Role of acidic and aromatic amino acids in Rhodobacter capsulatus cytochrome c1. A site-directed mutagenesis study.

  Biochemistry 20030729

• Critical role of Ca2+ ions in the reaction mechanism of Euphorbia characias peroxidase.

  Biochemistry 20030729

• Identification and characterization of heme-interacting proteins in the malaria parasite, Plasmodium falciparum.

  The Journal of biological chemistry 20030725

• Kinetic modulation in carbonmonoxy derivatives of truncated hemoglobins: the role of distal heme pocket residues and extended apolar tunnel.

  The Journal of biological chemistry 20030718

• Scavenging with TEMPO* to identify peptide- and protein-based radicals by mass spectrometry: advantages of spin scavenging over spin trapping.

  Journal of the American Chemical Society 20030716

• The heme-heme oxygenase system: a molecular switch in wound healing.

  Blood 20030715

• NO orientation and tilting in (nitrosyl)iron(II) deuteroporphyrin IX.

  Inorganic chemistry 20030714

• Stereoselective in vitro formation of c-type cytochrome variants from Hydrogenobacter thermophilus containing only a single thioether bond.

  The Journal of biological chemistry 20030704

• Regulation of CO production in cerebral microvessels of newborn pigs.

  American journal of physiology. Heart and circulatory physiology 20030701

• Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization.

  American journal of physiology. Heart and circulatory physiology 20030701

• Modulation of the NO trans effect in heme proteins: implications for the activation of soluble guanylate cyclase.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030701

• Perfusion-Perls and -Turnbull methods supplemented by DAB intensification for nonheme iron histochemistry: demonstration of the superior sensitivity of the methods in the liver, spleen, and stomach of the rat.

  Histochemistry and cell biology 20030701

• Effects of occupational exposure to diesel exhaust on porphyrin metabolism in lymphocytes of workers employed at black coal and oil-shale mines.

  American journal of industrial medicine 20030701

• Either soluble or plastidic expression of recombinant protoporphyrinogen oxidase modulates tetrapyrrole biosynthesis and photosynthetic efficiency in transgenic rice.

  Bioscience, biotechnology, and biochemistry 20030701

• The effect of lead bioaccumulation on haem biosynthetic enzymes in fish.

  Journal of environmental biology 20030701

• Characterization of Drosophila nitric oxide synthase: a biochemical study.

  Biochemical and biophysical research communications 20030627

• MauG, a novel diheme protein required for tryptophan tryptophylquinone biogenesis.

  Biochemistry 20030624

• Stereoselectivity of each of the three steps of the heme oxygenase reaction: hemin to meso-hydroxyhemin, meso-hydroxyhemin to verdoheme, and verdoheme to biliverdin.

  Biochemistry 20030624

• Rupture of the hydrogen bond linking two Omega-loops induces the molten globule state at neutral pH in cytochrome c.

  Biochemistry 20030624

• The origin of the low-spin character of the resting state of cytochrome P450cam investigated by means of active site analogues.

  Chemical communications (Cambridge, England) 20030621

• Watching a protein as it functions with 150-ps time-resolved x-ray crystallography.

  Science (New York, N.Y.) 20030620

• Spectroscopic study of [Fe2O2(5-Et3-TPA)2]3+: nature of the Fe2O2 diamond core and its possible relevance to high-valent binuclear non-heme enzyme intermediates.

  Journal of the American Chemical Society 20030618

• Mechanism of low-density lipoprotein oxidation by hemoglobin-derived iron.

  Biochemistry 20030617

• Direct determination of the complete set of iron normal modes in a porphyrin-imidazole model for carbonmonoxy-heme proteins: [Fe(TPP)(CO)(1-MeIm)].

  Journal of the American Chemical Society 20030611

• Interaction of heme with variants of the heme chaperone CcmE carrying active site mutations and a cleavable N-terminal His tag.

  The Journal of biological chemistry 20030606

• Spectroscopic evidence for a heme-superoxide/Cu(I) intermediate in a functional model of cytochrome c oxidase.

  Journal of the American Chemical Society 20030604

• Symmetry and bonding in metalloporphyrins. A modern implementation for the bonding analyses of five- and six-coordinate high-spin iron(III)-porphyrin complexes through density functional calculation and NMR spectroscopy.

  Journal of the American Chemical Society 20030604

• Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes.

  Biochemistry 20030603

• Architecture of the Qo site of the cytochrome bc1 complex probed by superoxide production.

  Biochemistry 20030603

• Role of the interdomain linker probed by kinetics of CO ligation to an endothelial nitric oxide synthase mutant lacking the calmodulin binding peptide (residues 503-517 in bovine).

  Biochemistry 20030603

• Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI.

  Biochemistry 20030603

• Vasoactivity of S-nitrosohemoglobin: role of oxygen, heme, and NO oxidation states.

  Blood 20030601

• Molecular dynamics simulations of lignin peroxidase in solution.

  Biophysical journal 20030601

• A two-faced molecule offers NO explanation: the proximal binding of nitric oxide to haem.

  Biochemical Society transactions 20030601

• The essential role of fumarate reductase in haem-dependent growth stimulation of Bacteroides fragilis.

  Microbiology (Reading, England) 20030601

• In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum.

  Parasitology research 20030601

• NMR investigation of the alkaline-like conformational transition of horse heart cytochrome c in the presence of exogenous thiazole.

  Biophysical chemistry 20030601

• Relationships of ligand binding, redox properties, and protonation in Coprinus cinereus peroxidase.

  The Journal of biological chemistry 20030523

• Is a Q-cycle-like mechanism operative in dihaemic succinate:quinone and quinol:fumarate oxidoreductases?

  FEBS letters 20030522

• Reactions of Mycobacterium tuberculosis truncated hemoglobin O with ligands reveal a novel ligand-inclusive hydrogen bond network.

  Biochemistry 20030520

• Interaction with membrane lipids and heme ligand binding properties of Escherichia coli flavohemoglobin.

  Biochemistry 20030520

• Nitrosylation of cytochrome c during apoptosis.

  The Journal of biological chemistry 20030516

• Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.

  European journal of pharmacology 20030516

• Distal site aspartate is essential in the catalase activity of catalase-peroxidases.

  Biochemistry 20030513

• Transient kinetic studies of heme reduction in Escherichia coli nitrate reductase A (NarGHI) by menaquinol.

  Biochemistry 20030513

• Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans.

  Biochemistry 20030506

• Synthesis and characterization of reduced heme and heme/copper carbonmonoxy species.

  Inorganic chemistry 20030505

• Single-step immunoaffinity purification and characterization of dodecylmaltoside-solubilized human neutrophil flavocytochrome b.

  Biochimica et biophysica acta 20030502

• A new intracellular pathway of haem detoxification in the midgut of the cattle tick Boophilus microplus: aggregation inside a specialized organelle, the hemosome.

  The Journal of experimental biology 20030501

• Apoptosis is induced by decline of mitochondrial ATP synthesis in erythroleukemia cells.

  Free radical biology & medicine 20030501

• Cytochrome P460 of Nitrosomonas europaea. Formation of the heme-lysine cross-link in a heterologous host and mutagenic conversion to a non-cross-linked cytochrome c'.

  European journal of biochemistry 20030501

• Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP.

  Experimental biology and medicine (Maywood, N.J.) 20030501

• Heme structural perturbation of PEG-modified horseradish peroxidase C in aromatic organic solvents probed by optical absorption and resonance Raman dispersion spectroscopy.

  Biophysical journal 20030501

• The structure of Acidithiobacillus ferrooxidans c(4)-cytochrome: a model for complex-induced electron transfer tuning.

  Structure (London, England : 1993) 20030501

• Diffusion measurements by electrospray mass spectrometry for studying solution-phase noncovalent interactions.

  Journal of the American Society for Mass Spectrometry 20030501

• Cytochrome b559 content in isolated photosystem II reaction center preparations.

  European journal of biochemistry 20030501

• Green or red: what stops the traffic in the tetrapyrrole pathway?

  Trends in plant science 20030501

• Partial purification and characterization of an ascorbate-reducible b-type cytochrome from the plasma membrane of Arabidopsis thaliana leaves.

  Protoplasma 20030501

• Proton conduction through full-length gp91phox requires histidine 115.

  Protoplasma 20030501

• Neutralization of toxic heme by Plasmodium falciparum histidine-rich protein 2.

  Journal of biochemistry 20030501

• [Structure-function relationships of NO synthase: electron transfer reaction].

  Seikagaku. The Journal of Japanese Biochemical Society 20030501

• Potential mechanism by which resveratrol, a red wine constituent, protects neurons.

  Annals of the New York Academy of Sciences 20030501

• Heme cleavage with remarkable ease: paramagnetic intermediates formed by aerobic oxidation of a meso-amino-substituted iron porphyrin.

  Journal of the American Chemical Society 20030423

• Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate.

  Biochemistry 20030422

• A novel heme and peroxide-dependent tryptophan-tyrosine cross-link in a mutant of cytochrome c peroxidase.

  Journal of molecular biology 20030418

• The heme domain of cellobiose oxidoreductase: a one-electron reducing system.

  Biochimica et biophysica acta 20030418

• Involvement of ABC7 in the biosynthesis of heme in erythroid cells: interaction of ABC7 with ferrochelatase.

  Blood 20030415

• Reaction mechanism and regulation of cystathionine beta-synthase.

  Biochimica et biophysica acta 20030411

• Structural insights into mutations of cystathionine beta-synthase.

  Biochimica et biophysica acta 20030411

• Coupled oxidation vs heme oxygenation: insights from axial ligand mutants of mitochondrial cytochrome b5.

  Journal of the American Chemical Society 20030409

• Conformational differences in Mycobacterium tuberculosis catalase-peroxidase KatG and its S315T mutant revealed by resonance Raman spectroscopy.

  Biochemistry 20030408

• Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode.

  Biochemistry 20030408

• Structure and kinetic properties of Paracoccus pantotrophus cytochrome cd1 nitrite reductase with the d1 heme active site ligand tyrosine 25 replaced by serine.

  The Journal of biological chemistry 20030404

• A functional domain of the alpha1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding.

  The Journal of biological chemistry 20030404

• Bcl-XL is required for heme synthesis during the chemical induction of erythroid differentiation of murine erythroleukemia cells independently of its antiapoptotic function.

  Blood 20030401

• Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.

  Nature cell biology 20030401

• Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.

  Proceedings of the National Academy of Sciences of the United States of America 20030401

• pH-induced alteration and oxidative destruction of heme in purified chromaffin granule cytochrome b(561): implications for the oxidative stress in catecholaminergic neurons.

  Biochemistry 20030401

• Proton NMR study of chemically modified horse heart ferricytochrome c confirms the presence of histidine and lysine-ligated conformers in 30% acetonitrile solution.

  Journal of inorganic biochemistry 20030401

• Chemiluminescent-based methods to detect subpicomole levels of c-type cytochromes.

  Analytical biochemistry 20030401

• Deregulation of iron homeostasis and cold-preservation injury to rat liver stored in University of Wisconsin solution.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20030401

• S-nitrosylation in health and disease.

  Trends in molecular medicine 20030401

• A density functional investigation of the extradiol cleavage mechanism in non-heme iron catechol dioxygenases.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030401

• Cytochrome c location in phosphatidylcholine/cardiolipin model membranes: resonance energy transfer study.

  Biophysical chemistry 20030325

• Alkylation of manganese(II) tetraphenylporphyrin by antimalarial fluorinated artemisinin derivatives.

  Bioorganic & medicinal chemistry letters 20030324

• Design of a ruthenium-labeled cytochrome c derivative to study electron transfer with the cytochrome bc1 complex.

  Biochemistry 20030318

• Hydrogen-peroxide-induced heme degradation in red blood cells: the protective roles of catalase and glutathione peroxidase.

  Biochimica et biophysica acta 20030317

• Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells.

  The Journal of biological chemistry 20030314

• Resonance Raman investigation of the interaction of thromboxane synthase with substrate analogues.

  Biochemistry 20030311

• Effect of protein dynamics upon reactions that occur in the heme pocket of horseradish peroxidase.

  Biochemistry 20030311

• Two-dimensional NMR study of the heme active site structure of chloroperoxidase.

  The Journal of biological chemistry 20030307

• Analysis of heme structural heterogeneity in Mycobacterium tuberculosis catalase-peroxidase (KatG).

  The Journal of biological chemistry 20030307

• Spectroscopic characterization of five- and six-coordinate ferrous-NO heme complexes. Evidence for heme Fe-proximal cysteinate bond cleavage in the ferrous-NO adducts of the Trp-409Tyr/Phe proximal environment mutants of neuronal nitric oxide synthase.

  Biochemistry 20030304

• Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megaterium.

  The Biochemical journal 20030301

• Endogenous carbon monoxide is an endothelial-derived vasodilator factor in the mesenteric circulation.

  American journal of physiology. Heart and circulatory physiology 20030301

• Receptor binding assay for nitric oxide- and heme-independent activators of soluble guanylate cyclase.

  Analytical biochemistry 20030301

• Regulation of the aerobic respiratory chain in the facultatively aerobic and hyperthermophilic archaeon Pyrobaculum oguniense.

  Microbiology (Reading, England) 20030301

• The generation of free radicals by nitric oxide synthase.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030301

• Aluminum-induced oxidative stress in rat brain: response to combined administration of citric acid and HEDTA.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030301

• [Heme biosynthesis and iron metabolism].

  Seikagaku. The Journal of Japanese Biochemical Society 20030301

• [Diversity and anti-oxidative effects of bilirubin].

  Seikagaku. The Journal of Japanese Biochemical Society 20030301

• [Genetic defect of bilirubin-glucuronosyltransferase].

  Seikagaku. The Journal of Japanese Biochemical Society 20030301

• Solution 1H NMR investigation of the active site molecular and electronic structures of substrate-bound, cyanide-inhibited HmuO, a bacterial heme oxygenase from Corynebacterium diphtheriae.

  The Journal of biological chemistry 20030227

• Irradiation and modified atmosphere packaging effects on residual nitrite, ascorbic acid, nitrosomyoglobin, and color in sausage.

  Journal of agricultural and food chemistry 20030226

• Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase.

  Biochemistry 20030225

• Effect of pH on the iso-1-cytochrome c denatured state: changing constraints due to heme ligation.

  Biochemistry 20030225

• Phospholipid assisted folding of a denatured heme protein: effect of phosphatidylethanolamine.

  Biochemical and biophysical research communications 20030221

• Substitutions for glutamate 101 in subunit II of cytochrome c oxidase from Rhodobacter sphaeroides result in blocking the proton-conducting K-channel.

  Biochemistry 20030218

• Structure of the Clade 1 catalase, CatF of Pseudomonas syringae, at 1.8 A resolution.

  Proteins 20030215

• Cytochrome c maturation. The in vitro reactions of horse heart apocytochrome c and Paracoccus dentrificans apocytochrome c550 with heme.

  The Journal of biological chemistry 20030214

• Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi.

  Journal of medicinal chemistry 20030213

• Phosphatase activity of non-heme chloroperoxidase from the bacterium Serratia marcescens.

  FEBS letters 20030211

• Purification of a cytochrome bc-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunity of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1.

  The Journal of biological chemistry 20030207

• Passage of heme-iron across the envelope of Staphylococcus aureus.

  Science (New York, N.Y.) 20030207

• Aberrant iron accumulation and oxidized status of erythroid-specific delta-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts.

  Blood 20030201

• Distal heme pocket regulation of ligand binding and stability in soybean leghemoglobin.

  Proteins 20030201

• High-resolution structure and biochemical properties of a recombinant Proteus mirabilis catalase depleted in iron.

  Proteins 20030201

• Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

  The Journal of pharmacology and experimental therapeutics 20030201

• High-pressure 1H NMR study of pressure-induced structural changes in the heme environments of metcyanomyoglobins.

  Protein science : a publication of the Protein Society 20030201

• An automatic method to generate force-field parameters for hetero-compounds.

  Acta crystallographica. Section D, Biological crystallography 20030201

• Crystallization and preliminary X-ray diffraction analysis of the di-haem cytochrome c peroxidase from Pseudomonas stutzeri.

  Acta crystallographica. Section D, Biological crystallography 20030201

• Expression and characterization of cyanobacterium heme oxygenase, a key enzyme in the phycobilin synthesis. Properties of the heme complex of recombinant active enzyme.

  European journal of biochemistry 20030201

• Different pathways of radical translocation in yeast cytochrome c peroxidase and its W191F mutant on reaction with H(2)O(2) suggest an antioxidant role.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030201

• 1H NMR structure of the heme pocket of HNO-myoglobin.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030201

• A novel iron centre in the split-Soret cytochrome c from Desulfovibrio desulfuricans ATCC 27774.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030201

• Iron depletion without anemia is not associated with impaired selenium status in college-aged women.

  Biological trace element research 20030201

• Effects of degree of hydrolysis and pH on the solubility of heme-iron enriched peptide in hemoglobin hydrolysate.

  Bioscience, biotechnology, and biochemistry 20030201

• Role of conserved tyrosine 343 in intramolecular electron transfer in human sulfite oxidase.

  The Journal of biological chemistry 20030131

• Structural biology. Complex II is complex too.

  Science (New York, N.Y.) 20030131

• Architecture of succinate dehydrogenase and reactive oxygen species generation.

  Science (New York, N.Y.) 20030131

• Mössbauer studies of the non-heme iron and cytochrome b559 in a Chlamydomonas reinhardtii PSI- mutant and their interactions with alpha-tocopherol quinone.

  FEBS letters 20030130

• Assignment of heme resonances and determination of the electronic structures of high- and low-spin nitrophorin 2 by 1H and 13C NMR spectroscopy: an explanation of the order of heme methyl resonances in high-spin ferriheme proteins.

  Biochemistry 20030128

• Selective one-electron reduction of Nitrosomonas europaea hydroxylamine oxidoreductase with nitric oxide.

  Inorganic chemistry 20030127

• Essential histidine and tryptophan residues in CcsA, a system II polytopic cytochrome c biogenesis protein.

  The Journal of biological chemistry 20030124

• The role of the hydrophobic distal heme pocket of CooA in ligand sensing and response.

  The Journal of biological chemistry 20030124

• High-pressure FTIR study of the stability of horseradish peroxidase. Effect of heme substitution, ligand binding, Ca++ removal, and reduction of the disulfide bonds.

  Biochemistry 20030121

• Comparison of substrate metabolism by cytochromes P450 2B1, 2B4, and 2B6: relationship of heme spin state, catalysis, and the effects of cytochrome b5.

  Journal of inorganic biochemistry 20030115

• NMR study of the conformational transition of cytochrome c upon the displacement of Met80 by exogenous ligand: structural and magnetic characterization of azidoferricytochrome c.

  Biophysical chemistry 20030108

• Hypoxic up-regulation of erythroid 5-aminolevulinate synthase.

  Blood 20030101

• Unfolding and pH studies on manganese peroxidase: role of heme and calcium on secondary structure stability.

  Biopolymers 20030101

• Spectroscopic and electrochemical studies of horse myoglobin in dimethyl sulfoxide.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030101

• Multiple mechanisms and multiple oxidants in P450-catalyzed hydroxylations.

  Archives of biochemistry and biophysics 20030101

• Structural alterations of the heme environment of cytochrome P450cam and the Y96F mutant as deduced by resonance Raman spectroscopy.

  Archives of biochemistry and biophysics 20030101

• Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy.

  American journal of human genetics 20030101

• Effects of continuous light exposure on antioxidant enzymes, porphyric enzymes and cellular damage in the Harderian gland of the Syrian hamster.

  Journal of pineal research 20030101

• Molecular profiling of anemia in acute renal allograft rejection using DNA microarrays.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20030101

• Expression of recombinant Pseudomonas stutzeri di-heme cytochrome c4 by high-cell-density fed-batch cultivation of Pseudomonas putida.

  Protein expression and purification 20030101

• Antileishmanial drug development: exploitation of parasite heme dependency.

  Molecular and biochemical parasitology 20030101

• Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteins.

  BMC genomics 20030101

• Antioxidant protein 2 prevents methemoglobin formation in erythrocyte hemolysates.

  European journal of biochemistry 20030101

• Heme oxygenase activity and some indices of antioxidant protection in rat liver and kidney in glycerol model of rhabdomyolysis.

  Bulletin of experimental biology and medicine 20030101

• [Methemalbuminnemia after massive hemolysis during blackwater fever].

  Annales de biologie clinique 20030101

• [Mechanisms of nitric oxide synthesis and action in cells].

  Medicina (Kaunas, Lithuania) 20030101

• Resonance Raman spectroscopy study of change of iron spin state in horseradish peroxidase C induced by removal of calcium.

  Biopolymers 20030101

• [Clinical manifestations of porphyrin metabolism disorders].

  Terapevticheskii arkhiv 20030101

• [Metabolism of heme and hemeproteins and some indices of the antioxidant system in rat erythrocytes and tissues under anemia caused by phenylhydrazine].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20030101

• The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.

  Blood cells, molecules & diseases 20030101

• Mechanism of peroxynitrite interaction with cytochrome c.

  Acta biochimica Polonica 20030101

• [Structure and electronic properties of heme complexes with various ligands].

  Biofizika 20030101

• Function and structure of complex II of the respiratory chain.

  Annual review of biochemistry 20030101

• [Activity of key enzymes of heme metabolism and cytochrome P-450 content in the rat liver in experimental rhabdomyolysis and hemolytic anemia].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20030101

• [Porphyria].

  Ryoikibetsu shokogun shirizu 20030101

• Control of the nitric oxide-cytochrome c oxidase signaling pathway under pathological and physiological conditions.

  IUBMB life 20030101

• [Hydrolysis of phosphoether bonds of heme-independent chloride peroxidase from Serratia marcescens].

  Bioorganicheskaia khimiia 20030101

• Double-drug development against antioxidant enzymes from Plasmodium falciparum.

  Redox report : communications in free radical research 20030101

• Biochemical characterization of porphobilinogen deaminase-deficient mice during phenobarbital induction of heme synthesis and the effect of enzyme replacement.

  Molecular medicine (Cambridge, Mass.) 20030101

• Characterization of the redox centers in dimethyl sulfide dehydrogenase from Rhodovulum sulfidophilum.

  Biochemistry 20021224

• Structural changes are induced in human neutrophil cytochrome b by NADPH oxidase activators, LDS, SDS, and arachidonate: intermolecular resonance energy transfer between trisulfopyrenyl-wheat germ agglutinin and cytochrome b(558).

  Biochimica et biophysica acta 20021223

• Oxidation of heme to beta- and delta-biliverdin by Pseudomonas aeruginosa heme oxygenase as a consequence of an unusual seating of the heme.

  Journal of the American Chemical Society 20021218

• A directional electron transfer regulator based on heme-chain architecture in the small tetraheme cytochrome c from Shewanella oneidensis.

  FEBS letters 20021218

• Structural basis for the molecular properties of cytochrome c6.

  Biochemistry 20021217

• Heme inhibits the mitochondrial import of coproporphyrinogen oxidase.

  Blood 20021215

• Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation.

  The Journal of biological chemistry 20021213

• The solution structure of the recombinant hemoglobin from the cyanobacterium Synechocystis sp. PCC 6803 in its hemichrome state.

  Journal of molecular biology 20021213

• A chlorine isotope effect for enzyme-catalyzed chlorination.

  Journal of the American Chemical Society 20021211

• Sulfate respiration in Desulfovibrio vulgaris Hildenborough. Structure of the 16-heme cytochrome c HmcA AT 2.5-A resolution and a view of its role in transmembrane electron transfer.

  The Journal of biological chemistry 20021206

• Theories on malarial pigment formation and quinoline action.

  International journal for parasitology 20021204

• Identification of two domains and distal histidine ligands to the four haems in the bacterial c-type cytochrome NapC; the prototype connector between quinol/quinone and periplasmic oxido-reductases.

  The Biochemical journal 20021201

• Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus.

  Structure (London, England : 1993) 20021201

• Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein.

  Chemical research in toxicology 20021201

• Hemin-mediated restoration of allylisopropylacetamide-inactivated CYP2B1: a role for glutathione and GRP94 in the heme-protein assembly.

  Archives of biochemistry and biophysics 20021201

• Effects of voluntary resistance exercise on heme biosynthesis in rats given glucocorticoid-injections.

  Bioscience, biotechnology, and biochemistry 20021201

• Molecular characterization of porphyrias in Italy: a diagnostic flow-chart.

  Cellular and molecular biology (Noisy-le-Grand, France) 20021201

• Interaction of heme with nitroxyl or nitric oxide amplifies heme oxygenase-1 induction: involvement of the transcription factor Nrf2.

  Cellular and molecular biology (Noisy-le-Grand, France) 20021201

• Unusual cyanide bindings to a heme-regulated phosphodiesterase from Escherichia coli: effect of Met95 mutations.

  Biochemical and biophysical research communications 20021129

• Molecular mechanism of the electron transfer reaction in cytochrome P450(cam)--putidaredoxin: roles of glutamine 360 at the heme proximal site.

  Biochemistry 20021126

• NO-induced activation mechanism of the heme-regulated eIF2alpha kinase.

  Journal of the American Chemical Society 20021120

• Nitrosyliron(III) porphyrinates: porphyrin core conformation and FeNO geometry. Any correlation?

  Journal of the American Chemical Society 20021120

• A new approach to the study of protein-protein interaction by FTIR: complex formation between cytochrome P450BM-3 heme domain and FMN reductase domain.

  Biochemistry 20021119

• Spectroelectrochemical evaluation of redox potentials of cysteine tryptophylquinone and two hemes c in quinohemoprotein amine dehydrogenase from Paracoccus denitrificans.

  Biochemistry 20021119

• Characterization of a human and mouse tetrapyrrole-binding protein.

  Archives of biochemistry and biophysics 20021115

• A mutation in subunit I of cytochrome oxidase from Rhodobacter sphaeroides results in an increase in steady-state activity but completely eliminates proton pumping.

  Biochemistry 20021112

• Fine-tuning of the binding and dissociation of CO by the amino acids of the heme pocket of Coprinus cinereus peroxidase.

  Biochemistry 20021105

• Expression analysis of the two ferrochelatase genes in Arabidopsis in different tissues and under stress conditions reveals their different roles in haem biosynthesis.

  Plant molecular biology 20021101

• A novel haem compound accumulated in Escherichia coli overexpressing the cydDC operon, encoding an ABC-type transporter required for cytochrome assembly.

  Archives of microbiology 20021101

• Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20021101

• Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme.

  Molecular pharmacology 20021101

• The reactivity of alpha-hydroxyhaem and verdohaem bound to haem oxygenase-1 to dioxygen and sodium dithionite.

  European journal of biochemistry 20021101

• The antithyroid agent 6-n-propyl-2-thiouracil is a mechanism-based inactivator of the neuronal nitric oxide synthase isoform.

  Archives of biochemistry and biophysics 20021101

• Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme.

  The EMBO journal 20021101

• NMR structure of the heme chaperone CcmE reveals a novel functional motif.

  Structure (London, England : 1993) 20021101

• Effect of isotope substitution and controlled dehydration on the photoinduced electron transport reactions of quinone acceptors and multiheme cytochrome C in bacterial photosynthetic reaction center.

  Biochemistry. Biokhimiia 20021101

• On the biosynthesis of Rhodnius prolixus heme-binding protein.

  Insect biochemistry and molecular biology 20021101

• Structure-based mechanism of O2 sensing and ligand discrimination by the FixL heme domain of Bradyrhizobium japonicum.

  Biochemistry 20021029

• Redox-linked protonation of cytochrome c oxidase: the effect of chloride bound to CuB.

  Biochemistry 20021029

• Cyclic and hairpin peptide complexes of heme.

  Journal of the American Chemical Society 20021023

• Involvement of delta-aminolaevulinate synthase encoded by the parasite gene in de novo haem synthesis by Plasmodium falciparum.

  The Biochemical journal 20021015

• Carbon monoxide dilates cerebral arterioles by enhancing the coupling of Ca2+ sparks to Ca2+-activated K+ channels.

  Circulation research 20021004

• Influence of amino acid side chain packing on Fe-methionine coordination in thermostable cytochrome C.

  Journal of the American Chemical Society 20021002

• Crystal structures of unligated and CN-ligated Glycera dibranchiata monomer ferric hemoglobin components III and IV.

  Proteins 20021001

• Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase.

  Biochemistry 20021001

• Ligand binding properties and structural studies of recombinant and chemically modified hemoglobins altered at beta 93 cysteine.

  Biochemistry 20021001

• Binding and relaxometric properties of heme complexes with cyanogen bromide fragments of human serum albumin.

  Biophysical journal 20021001

• Electrochemical, FT-IR and UV/VIS spectroscopic properties of the caa3 oxidase from T. thermophilus.

  European journal of biochemistry 20021001

• Proximal ligand motions in H93G myoglobin.

  European journal of biochemistry 20021001

• Spectroscopic characterization and ligand-binding properties of chlorite dismutase from the chlorate respiring bacterial strain GR-1.

  European journal of biochemistry 20021001

• Cloning and expression of a Porphyromonas gingivalis gene for protoporphyrinogen oxidase by complementation of a hemG mutant of Escherichia coli.

  Oral microbiology and immunology 20021001

• Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-1.

  Journal of molecular medicine (Berlin, Germany) 20021001

• Composition of the heme centers in chromaffin granule cytochrome b(561).

  Annals of the New York Academy of Sciences 20021001

• The aerobic electron transport system of Eikenella corrodens.

  Canadian journal of microbiology 20021001

• Reductive activation of dioxygen by a myoglobin reconstituted with a flavohemin.

  Journal of the American Chemical Society 20020925

• Assembly and activation of heme-deficient neuronal NO synthase with various porphyrins.

  Journal of inorganic biochemistry 20020920

• Mesopone cytochrome c peroxidase: functional model of heme oxygenated oxidases.

  Journal of inorganic biochemistry 20020920

• Influence of the distal his in imparting imidazolate character to the proximal his in heme peroxidase: (1)h NMR spectroscopic study of cyanide-inhibited his42-->ala horseradish peroxidase.

  Journal of the American Chemical Society 20020918

• Structure of a nitric oxide synthase heme protein from Bacillus subtilis.

  Biochemistry 20020917

• Semi-quantitative estimation of heme/hemoprotein with dichlorodihydrofluorescin diacetate.

  Analytical biochemistry 20020915

• The Escherichia coli cytochrome c maturation (Ccm) system does not detectably attach heme to single cysteine variants of an apocytochrome c.

  The Journal of biological chemistry 20020913

• Analysis of the L116K variant of CooA, the heme-containing CO sensor, suggests the presence of an unusual heme ligand resulting in novel activity.

  The Journal of biological chemistry 20020913

• Identification of novel hemes generated by heme A synthase: evidence for two successive monooxygenase reactions.

  Biochemistry 20020910

• Inter- and intra-molecular electron transfer in the cytochrome bc(1) complex.

  Biochimica et biophysica acta 20020910

• Stationary and time-resolved resonance Raman spectra of His77 and Met95 mutants of the isolated heme domain of a direct oxygen sensor from Escherichia coli.

  The Journal of biological chemistry 20020906

• Bidentate ligation of heme analogues; novel biomimetics of peroxidase active site.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20020902

• Structure-function relationship in type II cytochrome c(3) from Desulfovibrio africanus: a novel function in a familiar heme core.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020901

• Denaturant dependence of equilibrium unfolding intermediates and denatured state structure of horse ferricytochrome c.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020901

• Atypical attack of acute intermittent porphyria--paresis but no abdominal pain.

  Journal of internal medicine 20020901

• Heme deficiency interferes with the Ras-mitogen-activated protein kinase signaling pathway and expression of a subset of neuronal genes.

  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20020901

• The unfolding of oxidized c-type cytochromes: the instructive case of Bacillus pasteurii.

  Journal of molecular biology 20020823

• EPR and ENDOR characterization of intermediates in the cryoreduced oxy-nitric oxide synthase heme domain with bound L-arginine or N(G)-hydroxyarginine.

  Biochemistry 20020820

• Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme.

  Biochemistry 20020820

• Mass tool for diagnosis.

  Nature 20020815

• Direct wiring of cytochrome c's heme unit to an electrode: electrochemical studies.

  Journal of the American Chemical Society 20020814

• Multiple active intermediates in oxidation reaction catalyzed by synthetic heme-thiolate complex relevant to cytochrome p450.

  Journal of the American Chemical Society 20020814

• The kinetics of uptake and accumulation of 3,6-bis-omega-diethylamino-amyloxyxanthone by the human malaria parasite Plasmodium falciparum.

  Molecular and biochemical parasitology 20020807

• Structures of V45E and V45Y mutants and structure comparison of a variety of cytochrome b5 mutants.

  Acta crystallographica. Section D, Biological crystallography 20020801

• Process development for heme-enriched peptide by enzymatic hydrolysis of hemoglobin.

  Bioresource technology 20020801

• Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives.

  Journal of medicinal chemistry 20020801

• Erythroid 5-aminolevulinate synthase, ferrochelatase and DMT1 expression in erythroid progenitors: differential pathways for erythropoietin and iron-dependent regulation.

  British journal of haematology 20020801

• Terminal steps of haem biosynthesis.

  Biochemical Society transactions 20020801

• Production of cobalamin and sirohaem in Bacillus megaterium: an investigation into the role of the branchpoint chelatases sirohydrochlorin ferrochelatase (SirB) and sirohydrochlorin cobalt chelatase (CbiX).

  Biochemical Society transactions 20020801

• Haem degradation in animals and plants.

  Biochemical Society transactions 20020801

• Cytochrome c maturation: a complex pathway for a simple task?

  Biochemical Society transactions 20020801

• Iron targeting to mitochondria in erythroid cells.

  Biochemical Society transactions 20020801

• A molecular, enzymatic and clinical study in a family with hereditary coproporphyria.

  Journal of inherited metabolic disease 20020801

• Heme degradation and human disease: diversity is the soul of life.

  Antioxidants & redox signaling 20020801

• Heme oxygenase: evolution, structure, and mechanism.

  Antioxidants & redox signaling 20020801

• Probing the role of active site histidine residues in the catalytic activity of lacrimal gland peroxidase.

  Molecular and cellular biochemistry 20020801

• An extracellular source of heme can induce a significant heme oxygenase mediated relaxation in the rat aorta.

  Canadian journal of physiology and pharmacology 20020801

• Hydrogen sulfide as a neuromodulator.

  Molecular neurobiology 20020801

• Thromboxane synthase: structure and function of protein and gene.

  Prostaglandins & other lipid mediators 20020801

• Carbon monoxide and bile pigments: surprising mediators of vascular function.

  Vascular medicine (London, England) 20020801

• Regioselective peroxo-dependent heme alkylation in P450(BM3)-F87G by aromatic aldehydes: effects of alkylation on cataysis.

  Biochemistry 20020730

• Novel histidine-heme covalent linkage in a hemoglobin.

  Journal of the American Chemical Society 20020724

• New insights into the heme cavity structure of catalase-peroxidase: a spectroscopic approach to the recombinant synechocystis enzyme and selected distal cavity mutants.

  Biochemistry 20020723

• Kinetics of inter-domain electron transfer in flavocytochrome cellobiose dehydrogenase from the white-rot fungus Phanerochaete chrysosporium.

  The Biochemical journal 20020715

• Responses of normal and sickle cell hemoglobin to S-nitroscysteine: implications for therapeutic applications of NO in treatment of sickle cell disease.

  Biophysical chemistry 20020710

• The interplay between heme iron and protein sulfhydryls in the reaction of dimeric Scapharca inaequivalvis hemoglobin with nitric oxide.

  Biophysical chemistry 20020710

• Heme nitrosylation of deoxyhemoglobin by s-nitrosoglutathione requires copper.

  The Journal of biological chemistry 20020705

• Modification of heme c binding motifs in the small subunit (NrfH) of the Wolinella succinogenes cytochrome c nitrite reductase complex.

  FEBS letters 20020703

• Nature of the displaceable heme-axial residue in the EcDos protein, a heme-based sensor from Escherichia coli.

  Biochemistry 20020702

• Oxophlorin and metallooxophlorin radicals--DFT studies.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20020702

• Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by N(G)-amino-L-arginine in vitro and in vivo.

  Molecular pharmacology 20020701

• NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle.

  British journal of pharmacology 20020701

• Erythrocyte aminolevulinate dehydratase activity as a lead marker in patients with chronic renal failure.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20020701

• Membrane heme as a host factor in reducing effectiveness of dihydroartemisinin.

  Biochemical pharmacology 20020701

• Mechanistic and molecular investigations on stabilization of horseradish peroxidase C.

  Analytical chemistry 20020701

• Stopped-flow kinetic analysis of the reaction catalyzed by the full-length yeast cystathionine beta-synthase.

  The Journal of biological chemistry 20020621

• Local dynamic properties of the heme pocket in native and solvent-induced molten-globule-like states of cytochrome c.

  Biophysical chemistry 20020619

• Spectroscopic properties of a mitochondrial cytochrome C with a single thioether bond to the heme prosthetic group.

  Biochemistry 20020618

• Binding of L-arginine and imidazole suggests heterogeneity of rat brain neuronal nitric oxide synthase.

  Biochemistry 20020618

• Crystal structures of deoxy- and carbonmonoxyhemoglobin F1 from the hagfish Eptatretus burgeri.

  The Journal of biological chemistry 20020614

• [Iron, infection and anemia--a classical triad].

  Wiener klinische Wochenschrift 20020614

• Crystal structure of rat apo-heme oxygenase-1 (HO-1): mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms.

  Biochemistry 20020611

• Site-specific cross-linking of human and bovine hemoglobins differentially alters oxygen binding and redox side reactions producing rhombic heme and heme degradation.

  Biochemistry 20020611

• Spectral properties of bacterial nitric-oxide reductase: resolution of pH-dependent forms of the active site heme b3.

  The Journal of biological chemistry 20020607

• hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90.

  The Journal of biological chemistry 20020607

• Novel oxazolidinone based compounds as inhibitors of aromatase and the use of the substrate-heme complex approach in the rationalisation of these compounds.

  Biochemical and biophysical research communications 20020607

• Heme oxygenase activity in placenta: direct dependence on oxygen availability.

  American journal of physiology. Heart and circulatory physiology 20020601

• New insights into the allosteric mechanism of human hemoglobin from molecular dynamics simulations.

  Biophysical journal 20020601

• Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6.

  The Journal of pharmacology and experimental therapeutics 20020601

• The carbon monoxide derivative of human hemoglobin carrying the double mutation LeuB10-->Tyr and HisE7-->Gln on alpha and beta chains probed by infrared spectroscopy.

  Archives of biochemistry and biophysics 20020601

• Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: effects of hemin and biliverdin.

  Toxicology and applied pharmacology 20020601

• Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and aminolevulinic acid synthase.

  Free radical research 20020601

• Esterification of the propionate groups promotes alpha/beta hemoglobin chain homogeneity of CN-hemin binding.

  Biochemical and biophysical research communications 20020524

• Kinetics of iron release from pig spleen ferritin with bare platinum electrode reduction.

  Biophysical chemistry 20020523

• ['Acute intermittent porphyria' diagnosis. An odyssey in diagnosis].

  MMW Fortschritte der Medizin 20020523

• Electron-transfer mechanisms through biological redox chains in multicenter enzymes.

  Journal of the American Chemical Society 20020522

• Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization.

  Blood 20020515

• Ligand and oxidation-state specific regulation of the heme-based oxygen sensor FixL from Sinorhizobium meliloti.

  Biochemistry 20020514

• Interactions between the isolated oxygenase and reductase domains of neuronal nitric-oxide synthase: assessing the role of calmodulin.

  The Journal of biological chemistry 20020510

• Oxygen reduction by cellobiose oxidoreductase: the role of the haem group.

  FEBS letters 20020508

• Resonance Raman detection of the Fe-S bond in endothelial nitric oxide synthase.

  Biochemistry 20020507

• Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family.

  Biochemistry 20020507

• Low-temperature UV-visible and NMR spectroscopic investigations of O(2) binding to ((6)L)Fe(II), a ferrous heme bearing covalently tethered axial pyridine ligands.

  Inorganic chemistry 20020506

• The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions.

  The Journal of biological chemistry 20020503

• Spectroscopic characterization of mutations at the Phe41 position in the distal haem pocket of horseradish peroxidase C: structural and functional consequences.

  The Biochemical journal 20020501

• Characterization and crystallization of a novel haemoglobinase from pathogenic Escherichia coli.

  Acta crystallographica. Section D, Biological crystallography 20020501

• Cerebrovasodilatory contribution of endogenous carbon monoxide during seizures in newborn pigs.

  Pediatric research 20020501

• The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase.

  The EMBO journal 20020501

• Small Cab-like proteins regulating tetrapyrrole biosynthesis in the cyanobacterium Synechocystis sp. PCC 6803.

  Plant molecular biology 20020501

• Management of acute and cutaneous porphyrias.

  International journal of clinical practice 20020501

• A novel strategy against ischemia and reperfusion injury: cytoprotection with heme oxygenase system.

  Transplant immunology 20020501

• [Acute intermittent porphyria].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20020430

• Heme redox properties of S-nitrosated hemoglobin A0 and hemoglobin S: implications for interactions of nitric oxide with normal and sickle red blood cells.

  The Journal of biological chemistry 20020426

• Sol-gel encapsulated horseradish peroxidase: a catalytic material for peroxidation.

  Journal of the American Chemical Society 20020424

• Biomimetic studies of terminal oxidases: trisimidazole picket metalloporphyrins.

  Inorganic chemistry 20020422

• Electron transfer at the low-spin heme b of cytochrome bo(3) induces an environmental change of the catalytic enhancer glutamic acid-286.

  Biochimica et biophysica acta 20020422

• The role of the cross-link His-Tyr in the functional properties of the binuclear center in cytochrome c oxidase.

  The Journal of biological chemistry 20020419

• A comparative resonance Raman analysis of heme-binding PAS domains: heme iron coordination structures of the BjFixL, AxPDEA1, EcDos, and MtDos proteins.

  Biochemistry 20020416

• The 1.25 A resolution structure of the diheme NapB subunit of soluble nitrate reductase reveals a novel cytochrome c fold with a stacked heme arrangement.

  Biochemistry 20020416

• Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family.

  The Journal of biological chemistry 20020412

• Regulation of the heme A biosynthetic pathway in Saccharomyces cerevisiae.

  FEBS letters 20020410

• Control of nitric oxide synthase dimer assembly by a heme-NO-dependent mechanism.

  Biochemistry 20020409

• Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase.

  Biochemistry 20020409

• Unprecedented overmetabolism of a porphyrinogen substrate by coproporphyrinogen oxidase.

  Bioorganic & medicinal chemistry letters 20020408

• Structural dynamics of myoglobin: ligand migration among protein cavities studied by Fourier transform infrared/temperature derivative spectroscopy.

  The Journal of biological chemistry 20020405

• Heme distortions in sperm-whale carbonmonoxy myoglobin: correlations between rotational strengths and heme distortions in MD-generated structures.

  Journal of the American Chemical Society 20020403

• Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein.

  The Journal of pharmacology and experimental therapeutics 20020401

• Histidine pK(a) shifts and changes of tautomeric states induced by the binding of gallium-protoporphyrin IX in the hemophore HasA(SM).

  Protein science : a publication of the Protein Society 20020401

• Redox control in heme proteins: electrostatic substitution in the active site of leghemoglobin.

  Archives of biochemistry and biophysics 20020401

• Chemical shift-based constraints for solution structure determination of paramagnetic low-spin heme proteins with bis-His and His-CN axial ligands: the cases of oxidized cytochrome b(5) and Met80Ala cyano-cytochrome c.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020401

• Solution structure of cyanoferricytochrome c: ligand-controlled conformational flexibility and electronic structure of the heme moiety.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020401

• Purification and characterization of a membrane-bound enzyme complex from the sulfate-reducing archaeon Archaeoglobus fulgidus related to heterodisulfide reductase from methanogenic archaea.

  European journal of biochemistry 20020401

• Effects of modulators of protein phosphorylation on heme metabolism in human hepatic cells: induction of delta-aminolevulinic synthase mRNA and protein by okadaic acid.

  DNA and cell biology 20020401

• An examination of heme action in gene expression: heme and heme deficiency affect the expression of diverse genes in erythroid k562 and neuronal PC12 cells.

  DNA and cell biology 20020401

• Membrane phospholipid reorganization differentially regulates metallothionein and heme oxygenase by heme-hemopexin.

  DNA and cell biology 20020401

• Pharmacological interventions for the treatment of neonatal jaundice.

  Seminars in neonatology : SN 20020401

• Central heme oxygenase-carbon monoxide pathway in the control of breathing under normoxia and hypoxia.

  Respiratory physiology & neurobiology 20020401

• Mitochondrial ferredoxin is required for heme A synthesis in Saccharomyces cerevisiae.

  The Journal of biological chemistry 20020322

• Kinetic characterization of compound I formation in the thermostable cytochrome P450 CYP119.

  The Journal of biological chemistry 20020322

• Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress.

  The Journal of biological chemistry 20020315

• Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties.

  Blood 20020315

• Mapping of the chick heme oxygenase-1 proximal promoter for responsiveness to metalloporphyrins.

  Archives of biochemistry and biophysics 20020315

• Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer.

  Biochemistry 20020312

• A bacterial cytochrome c heme lyase. CcmF forms a complex with the heme chaperone CcmE and CcmH but not with apocytochrome c.

  The Journal of biological chemistry 20020308

• Site-directed mutagenesis reveals the essentiality of the conserved residues in the putative diiron active site of the trypanosome alternative oxidase.

  The Journal of biological chemistry 20020308

• Evaluation of lead exposure in workers at secondary lead smelters in South Korea: with focus on activity of erythrocyte pyrimidine 5'-nucleotidase (P5N).

  The Science of the total environment 20020308

• Alterations of heme metabolism in lymphocytes and metal content in blood plasma as markers of diesel fuels effects on human organism.

  The Science of the total environment 20020308

• Alkylation of heme by the antimalarial drug artemisinin.

  Chemical communications (Cambridge, England) 20020307

• Structure and spectroscopy of the periplasmic cytochrome c nitrite reductase from Escherichia coli.

  Biochemistry 20020305

• Nitric oxide (NO) traffic in endothelial NO synthase. Evidence for a new NO binding site dependent on tetrahydrobiopterin?

  The Journal of biological chemistry 20020301

• The mutation K30D disrupts the only salt bridge at the subunit interface of the homodimeric hemoglobin from Scapharca inaequivalvis and changes the mechanism of cooperativity.

  The Journal of biological chemistry 20020301

• Controlling ligand binding in myoglobin by mutagenesis.

  The Journal of biological chemistry 20020301

• The molecular chaperone Hsp90 mediates heme activation of the yeast transcriptional activator Hap1.

  The Journal of biological chemistry 20020301

• Asp-225 and glu-375 in autocatalytic attachment of the prosthetic heme group of lactoperoxidase.

  The Journal of biological chemistry 20020301

• Increasing the redox potential of isoform 1 of yeast cytochrome c through the modification of select haem interactions.

  The Biochemical journal 20020301

• Measurement of ferrochelatase activity using a novel assay suggests that plastids are the major site of haem biosynthesis in both photosynthetic and non-photosynthetic cells of pea (Pisum sativum L.).

  The Biochemical journal 20020301

• Effect of antifungal azoles on the heme detoxification system of malarial parasite.

  Journal of biochemistry 20020301

• Sideroblastic anaemias.

  British journal of haematology 20020301

• From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs.

  Accounts of chemical research 20020301

• Heme-artemisinin adducts are crucial mediators of the ability of artemisinin to inhibit heme polymerization.

  Chemistry & biology 20020301

• Spectroscopic studies on human serum albumin and methemalbumin: optical, steady-state, and picosecond time-resolved fluorescence studies, and kinetics of substrate oxidation by methemalbumin.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020301

• Catalytic mechanism of heme oxygenase through EPR and ENDOR of cryoreduced oxy-heme oxygenase and its Asp 140 mutants.

  Journal of the American Chemical Society 20020227

• Reactivity of hydroperoxide bound to a mononuclear non-heme iron site.

  Inorganic chemistry 20020225

• Reactivity of iron verdohemes with phenylmagnesium bromide. Formation of paramagnetic iron-phenyl complexes.

  Inorganic chemistry 20020225

• Characterization of a cytochrome b(558) ferric/cupric reductase from rabbit duodenal brush border membranes.

  Biochemical and biophysical research communications 20020222

• Nitrones are suitable ligands for heme models: X-ray crystal structure of the first metalloporphyrin nitrone complex.

  Chemical communications (Cambridge, England) 20020221

• Mutants of the CuA site in cytochrome c oxidase of Rhodobacter sphaeroides: I. Spectral and functional properties.

  Biochemistry 20020219

• Six- to five-coordinate heme-nitrosyl conversion in cytochrome c' and its relevance to guanylate cyclase.

  Biochemistry 20020219

• Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor.

  The Biochemical journal 20020215

• The leghemoglobin proximal heme pocket directs oxygen dissociation and stabilizes bound heme.

  Proteins 20020215

• On the pro-oxidant effects of haemozoin.

  FEBS letters 20020213

• Interaction of cimetidine with P450 in a mouse model of hepatocarcinogenesis initiation.

  British journal of cancer 20020212

• Clotrimazole binds to heme and enhances heme-dependent hemolysis: proposed antimalarial mechanism of clotrimazole.

  The Journal of biological chemistry 20020208

• Role of the preoptic carbon monoxide pathway in endotoxin fever in rats.

  Brain research 20020208

• Alkylating capacity and reaction products of antimalarial trioxanes after activation by a heme model.

  The Journal of organic chemistry 20020208

• Interactions between heme d and heme b595 in quinol oxidase bd from Escherichia coli: a photoselection study using femtosecond spectroscopy.

  Biochemistry 20020205

• Induction of microsomal cytochrome P450s by tire-leachate compounds, habitat components of Aedes albopictus mosquito larvae.

  Archives of insect biochemistry and physiology 20020201

• Kinetic studies of novel di- and tri-propionate substrates for the chicken red blood cell enzyme coproporphyrinogen oxidase.

  Journal of biochemistry 20020201

• Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme.

  Free radical biology & medicine 20020201

• Exploration of the diaphorase activity of neutrophil NADPH oxidase.

  European journal of biochemistry 20020201

• Rapid intrachain binding of histidine-26 and histidine-33 to heme in unfolded ferrocytochrome C.

  Biochemistry 20020129

• Complex formation of cytochrome P450cam with Putidaredoxin. Evidence for protein-specific interactions involving the proximal thiolate ligand.

  The Journal of biological chemistry 20020125

• The Saccharomyces cerevisiae mitochondrial succinate:ubiquinone oxidoreductase.

  Biochimica et biophysica acta 20020117

• Quinol:fumarate oxidoreductases and succinate:quinone oxidoreductases: phylogenetic relationships, metal centres and membrane attachment.

  Biochimica et biophysica acta 20020117

• Purification, crystallisation and preliminary crystallographic studies of succinate:ubiquinone oxidoreductase from Escherichia coli.

  Biochimica et biophysica acta 20020117

• Replacement of the methionine axial ligand in cytochrome c(550) by a lysine: effects on the haem electronic structure.

  FEBS letters 20020116

• Perferryl complex of nitric oxide synthase: role in secondary free radical formation.

  Biochimica et biophysica acta 20020115

• A physiochemical mechanism of hemozoin (beta-hematin) synthesis by malaria parasite.

  Biochemical and biophysical research communications 20020111

• Characteristics and mechanism of formation of peroxide-induced heme to protein cross-linking in myoglobin.

  Biochemistry 20020108

• Role of CO in attenuated vasoconstrictor reactivity of mesenteric resistance arteries after chronic hypoxia.

  American journal of physiology. Heart and circulatory physiology 20020101

• The enzyme horseradish peroxidase is less compressible at higher pressures.

  Biophysical journal 20020101

• Regulation of cyclooxygenase by the heme-heme oxygenase system in microvessel endothelial cells.

  The Journal of pharmacology and experimental therapeutics 20020101

• The 2.6 A resolution structure of Rhodobacter capsulatus bacterioferritin with metal-free dinuclear site and heme iron in a crystallographic 'special position'.

  Acta crystallographica. Section D, Biological crystallography 20020101

• X-ray structure of nitric oxide reductase (cytochrome P450nor) at atomic resolution.

  Acta crystallographica. Section D, Biological crystallography 20020101

• Co-ordinate regulation of lactate metabolism genes in yeast: the role of the lactate permease gene JEN1.

  Molecular genetics and genomics : MGG 20020101

• dpp genes of Rhizobium leguminosarum specify uptake of delta-aminolevulinic acid.

  Molecular plant-microbe interactions : MPMI 20020101

• Studies of the reduction and protonation behavior of tetraheme cytochromes using atomic detail.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020101

• Metallothionein protects retinal pigment epithelial cells against apoptosis and oxidative stress.

  Experimental eye research 20020101

• Melatonin protects against oxidative stress caused by delta-aminolevulinic acid: implications for cancer reduction.

  Cancer investigation 20020101

• Functional expression of human heme oxygenase-1 (HO-1) driven by HO-1 promoter in vitro and in vivo.

  Journal of cellular biochemistry 20020101

• Probing electrostatic interactions in cytochrome c using site-directed chemical modification.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20020101

• Effect of heme structure on O(2)-binding properties of human serum albumin-heme hybrids: intramolecular histidine coordination provides a stable O(2)-adduct complex.

  Bioconjugate chemistry 20020101

• H93G myoglobin cavity mutant as versatile template for modeling heme proteins: magnetic circular dichroism studies of thiolate- and imidazole-ligated complexes.

  Biopolymers 20020101

• Time-resolved resonance Raman study on ultrafast structural relaxation and vibrational cooling of photodissociated carbonmonoxy myoglobin.

  Biopolymers 20020101

• Optical and IR absorption as probe of dynamics of heme proteins.

  Biopolymers 20020101

• Active site structure and dynamics of cytochrome c3 from Desulfovibrio gigas immobilized on electrodes.

  Biopolymers 20020101

• Raman evidence that the lyoprotectant poly(ethylene glycol) does not restore nativity to the heme active site of horseradish peroxidase suspended in organic solvents.

  Biomacromolecules 20020101

• Redox signaling.

  Molecular and cellular biochemistry 20020101

• Ferritin induction protects cortical astrocytes from heme-mediated oxidative injury.

  Neuroscience 20020101

• [Nephrologists and porphyrias].

  Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20020101

• [Conformational states of the water-soluble fragment of cytochrome b5. I. pH-induced denaturation].

  Molekuliarnaia biologiia 20020101

• Haematological, hepatic and renal alterations after repeated oral or intraperitoneal administration of monoisoamyl DMSA. I. Changes in male rats.

  Journal of applied toxicology : JAT 20020101

• [Heme oxygenase and carbon monoxide: the protection or the injury of cells?].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20020101

• A novel heme-DNA coordination complex and its stability.

  Nucleic acids research. Supplement (2001) 20020101

• Heme oxygenase-1 as a protective gene.

  Wiener klinische Wochenschrift 20020101

• Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III.

  The Journal of biological chemistry 20011228

• Effect of a charge relay on the vibrational frequencies of carbonmonoxy iron porphine adducts: the coupling of changes in axial ligand bond strength and porphine core size.

  Journal of the American Chemical Society 20011219

• Mechanism of peroxynitrite interaction with ferric hemoglobin and identification of nitrated tyrosine residues. CO(2) inhibits heme-catalyzed scavenging and isomerization.

  Biochemistry 20011218

• Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice.

  Blood 20011215

• Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme.

  Journal of inorganic biochemistry 20011215

• Mercuric chloride-induced spin or ligation state changes in ferric or ferrous human cystathionine beta-synthase inhibit enzyme activity.

  Journal of inorganic biochemistry 20011215

• Critical role of the neuronal nitric-oxide synthase heme proximal side residue, Arg418, in catalysis and electron transfer.

  Journal of inorganic biochemistry 20011215

• Role of conformational changes in the heme-dependent regulation of human soluble guanylate cyclase.

  Journal of inorganic biochemistry 20011215

• Control of nitric oxide dynamics by guanylate cyclase in its activated state.

  The Journal of biological chemistry 20011214

• Identification and biochemical characterization of Arabidopsis thaliana sulfite oxidase. A new player in plant sulfur metabolism.

  The Journal of biological chemistry 20011214

• The cytochrome c fold can be attained from a compact apo state by occupancy of a nascent heme binding site.

  The Journal of biological chemistry 20011207

• Controlling the functionality of cytochrome c(1) redox potentials in the Rhodobacter capsulatus bc(1) complex through disulfide anchoring of a loop and a beta-branched amino acid near the heme-ligating methionine.

  Biochemistry 20011204

• Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency.

  The EMBO journal 20011203

• Photodynamic and light independent action of 8 to 2 carboxylic free porphyrins on some haem-enzymes.

  The international journal of biochemistry & cell biology 20011201

• The structure of greylag goose oxy haemoglobin: the roles of four mutations compared with bar-headed goose haemoglobin.

  Acta crystallographica. Section D, Biological crystallography 20011201

• Influence of static and dynamic disorder on the visible and infrared absorption spectra of carbonmonoxy horseradish peroxidase.

  Biophysical journal 20011201

• Adrenodoxin-cytochrome P450scc interaction as revealed by EPR spectroscopy: comparison with the putidaredoxin-cytochrome P450cam system.

  Journal of biochemistry 20011201

• Effect of ibuprofen and warfarin on the allosteric properties of haem-human serum albumin. A spectroscopic study.

  European journal of biochemistry 20011201

• Steady-state and picosecond time-resolved fluorescence studies on native and apo seed coat soybean peroxidase.

  Biochemical and biophysical research communications 20011130

• Reactivity of mono-meso-substituted iron(II) octaethylporphyrin complexes with hydrogen peroxide in the absence of dioxygen. Evidence for nucleophilic attack on the heme.

  Journal of the American Chemical Society 20011128

• Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis.

  Biochemistry 20011127

• Thermodynamic analysis of the binding of aromatic hydroxamic acid analogues to ferric horseradish peroxidase.

  Biochemistry 20011120

• The covalent structure of the small subunit from Pseudomonas putida amine dehydrogenase reveals the presence of three novel types of internal cross-linkages, all involving cysteine in a thioether bond.

  The Journal of biological chemistry 20011116

• Neuronal nitric oxide synthase generates superoxide from the oxygenase domain.

  The Biochemical journal 20011115

• Phenylalanine 393 exerts thermodynamic control over the heme of flavocytochrome P450 BM3.

  Biochemistry 20011113

• Pivotal role of water in the mechanism of P450BM-3.

  Biochemistry 20011113

• The heme pocket afforded by Gly117 is crucial for proper heme ligation and activity of CooA.

  The Journal of biological chemistry 20011109

• Mapping of heme-binding domains in soluble guanylyl cyclase beta1 subunit.

  Biochemical and biophysical research communications 20011109

• Glu375Gln and Asp225Val mutants: about the nature of the covalent linkages between heme group and apo-Protein in bovine lactoperoxidase.

  Bioorganic & medicinal chemistry letters 20011105

• (F(8)TPP)Fe(II)/O(2) reactivity studies [F(8)TPP = tetrakis(2,6-difluorophenyl)porphyrinate(2-)]: spectroscopic (UV-Visible and NMR) and kinetic study of solvent-dependent (Fe/O(2) = 1:1 or 2:1) reversible O(2)-reduction and ferryl formation.

  Inorganic chemistry 20011105

• The critical role of the proximal calcium ion in the structural properties of horseradish peroxidase.

  The Journal of biological chemistry 20011102

• Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes.

  European journal of obstetrics, gynecology, and reproductive biology 20011101

• Insights into the alkaline transformation of ferricytochrome c from (1)H NMR studies in 30% acetonitrile-water.

  Protein science : a publication of the Protein Society 20011101

• Disturbance of cellular iron uptake and utilisation by aluminium.

  Journal of inorganic biochemistry 20011101

• A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin.

  Biochemistry 20011030

• Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.

  Biochemistry 20011030

• Covalent linkage of prosthetic heme to CYP4 family P450 enzymes.

  Biochemistry 20011030

• The electric field generated by photosynthetic reaction center induces rapid reversed electron transfer in the bc1 complex.

  Biochemistry 20011023

• Ring-opening and meso substitution from the reaction of cyanide ion with zinc verdohemes.

  Inorganic chemistry 20011022

• Identification of a spectrally stable proteolytic fragment of human neutrophil flavocytochrome b composed of the NH2-terminal regions of gp91(phox) and p22(phox).

  The Journal of biological chemistry 20011019

• The distal heme pocket of Escherichia coli flavohemoglobin probed by infrared spectroscopy.

  Biochimica et biophysica acta 20011018

• Regulation of the properties of the heme-NO complexes in nitric-oxide synthase by hydrogen bonding to the proximal cysteine.

  The Journal of biological chemistry 20011012

• The crystal structure of bar-headed goose hemoglobin in deoxy form: the allosteric mechanism of a hemoglobin species with high oxygen affinity.

  Journal of molecular biology 20011012

• Expression, purification, characterization, and NMR studies of highly deuterated recombinant cytochrome c peroxidase.

  Biochemistry 20011009

• Investigations of the roles of the distal heme environment and the proximal heme iron ligand in peroxide activation by heme enzymes via molecular engineering of myoglobin.

  Accounts of chemical research 20011001

• Induction of heme oxygenase-1 by phenylarsine oxide. Studies in cultured primary liver cells.

  Molecular and cellular biochemistry 20011001

• Isolation and characterization of a cDNA from soybean and its homolog from Escherichia coli, which both complement the light sensitivity of Escherichia coli hemH mutant strain VS101.

  Genes & genetic systems 20011001

• Inhibition of succinate-cytochrome C reductase by a ferromacrocyclic complex.

  Journal of enzyme inhibition 20011001

• Oxidative modification of tryptophan 43 in the heme vicinity of the F43W/H64L myoglobin mutant.

  The Journal of biological chemistry 20010928

• Unfolding of apomyoglobin examined by synchrotron footprinting.

  Biochemical and biophysical research communications 20010928

• Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides.

  Biochemistry 20010925

• Ligand-induced heme ruffling and bent no geometry in ultra-high-resolution structures of nitrophorin 4.

  Biochemistry 20010925

• Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase.

  Biochemistry 20010925

• Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa.

  Journal of molecular biology 20010921

• A structural role for tryptophan 188 of inducible nitric oxide synthase.

  Biochemical and biophysical research communications 20010914

• The solution structure and heme binding of the presequence of murine 5-aminolevulinate synthase.

  FEBS letters 20010914

• Interrogation of heme pocket environment of mammalian peroxidases with diatomic ligands.

  Biochemistry 20010911

• Binding of NO and CO to the d(1) Heme of cd(1) nitrite reductase from Pseudomonas aeruginosa.

  Biochemistry 20010911

• Verdoheme reactivity. Remarkable paramagnetically shifted (1)H NMR spectra of intermediates from the addition of hydroxide or methoxide with Fe(II) and Fe(III) verdohemes.

  Inorganic chemistry 20010910

• Hydrophobic modulation of heme properties in heme protein maquettes.

  Biochemistry 20010904

• Novel heme ligation in a c-type cytochrome involved in thiosulfate oxidation: EPR and MCD of SoxAX from Rhodovulum sulfidophilum.

  Biochemistry 20010904

• Inhibition of the neutrophil NADPH oxidase and associated H+ channel by diethyl pyrocarbonate (DEPC), a histidine-modifying agent: evidence for at least two target sites.

  The Biochemical journal 20010901

• Molecular requirements for inhibition of cytochrome p450 activities by roquefortine.

  Chemical research in toxicology 20010901

• Factors determining the special redox properties of photosynthetic cytochrome b559.

  European journal of biochemistry 20010901

• A spectroscopic investigation of the binding interactions between 4,5-dihydroxyxanthone and heme.

  Journal of inorganic biochemistry 20010901

• Regulatory network of tetrapyrrole biosynthesis--studies of intracellular signalling involved in metabolic and developmental control of plastids.

  Planta 20010901

• Factors that determine the unusually low reduction potential of cytochrome c550 in cyanobacterial photosystem II.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20010901

• In vivo hemoglobin allotropy in magnetic field.

  Bulletin of experimental biology and medicine 20010901

• Kinetic stability of designed glycosylation mutants of Coprinus cinereus peroxidase.

  Biochemical and biophysical research communications 20010831

• Denatured state thermodynamics: residual structure, chain stiffness and scaling factors.

  Journal of molecular biology 20010831

• Cationic ascorbate peroxidase isoenzyme II from tea: structural insights into the heme pocket of a unique hybrid peroxidase.

  Biochemistry 20010828

• N-hydroxyguanidines as new heme ligands: UV-visible, EPR, and resonance Raman studies of the interaction of various compounds bearing a C=NOH function with microperoxidase-8.

  Biochemistry 20010821

• Heme-ligating histidines in flavocytochrome b(558): identification of specific histidines in gp91(phox).

  The Journal of biological chemistry 20010817

• Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase.

  The Journal of biological chemistry 20010817

• Substrate flow in catalases deduced from the crystal structures of active site variants of HPII from Escherichia coli.

  Proteins 20010815

• Kinetics of CO binding to the haem domain of murine inducible nitric oxide synthase: differential effects of haem domain ligands.

  The Biochemical journal 20010815

• A novel heme protein, the Cu,Zn-superoxide dismutase from Haemophilus ducreyi.

  The Journal of biological chemistry 20010810

• Heme histidine ligands within gp91(phox) modulate proton conduction by the phagocyte NADPH oxidase.

  The Journal of biological chemistry 20010810

• Expression and characterization of the terminal heme synthetic enzymes from the hyperthermophile Aquifex aeolicus.

  FEMS microbiology letters 20010807

• Structure--function relationships of rat hepatic tryptophan 2,3-dioxygenase: identification of the putative heme-ligating histidine residues.

  Archives of biochemistry and biophysics 20010801

• X-ray absorption spectroscopic analysis of the high-spin ferriheme site in substrate-bound neuronal nitric-oxide synthase.

  Journal of biochemistry 20010801

• Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein.

  The EMBO journal 20010801

• The peroxidase activity of cytochrome c-550 from Paracoccus versutus.

  European journal of biochemistry 20010801

• The Rhizobium leguminosarum tonB gene is required for the uptake of siderophore and haem as sources of iron.

  Molecular microbiology 20010801

• Heme oxygenase-2 interaction with metalloporphyrins: function of heme regulatory motifs.

  Antioxidants & redox signaling 20010801

• [Pathophysiological roles of two types of gingipains in periodontal diseases].

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20010801

• The succinate dehydrogenase from the thermohalophilic bacterium Rhodothermus marinus: redox-Bohr effect on heme bL.

  Journal of bioenergetics and biomembranes 20010801

• Intramolecular electron transfer from c heme to d1 heme in bacterial cytochrome cd1 nitrite reductase occurs over the same distances at very different rates depending on the source of the enzyme.

  Biochemistry 20010724

• Site-directed mutation of the highly conserved region near the Q-loop of the cytochrome bd quinol oxidase from Escherichia coli specifically perturbs heme b595.

  Biochemistry 20010724

• Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.

  The Journal of biological chemistry 20010713

• A role for highly conserved carboxylate, aspartate-140, in oxygen activation and heme degradation by heme oxygenase-1.

  Journal of the American Chemical Society 20010711

• Kinetics of histidine deligation from the heme in GuHCl-unfolded Fe(III) cytochrome C studied by a laser-induced pH-jump technique.

  Journal of the American Chemical Society 20010711

• Monooxygenation mechanism by cytochrome p-450.

  Journal of the American Chemical Society 20010704

• Iron absorption: relative importance of iron transport pathways.

  American journal of hematology 20010701

• Influence of the heme pocket conformation on the structure and vibrations of the Fe-CO bond in myoglobin: a QM/MM density functional study.

  Biophysical journal 20010701

• Nitric oxide induces murine thymocyte apoptosis by oxidative injury and a p53-dependent mechanism.

  Journal of leukocyte biology 20010701

• Treatment of acute porphyria.

  Hospital medicine (London, England : 1998) 20010701

• Haemophore-mediated bacterial haem transport: evidence for a common or overlapping site for haem-free and haem-loaded haemophore on its specific outer membrane receptor.

  Molecular microbiology 20010701

• Chimeras of nitric-oxide synthase types I and III establish fundamental correlates between heme reduction, heme-NO complex formation, and catalytic activity.

  The Journal of biological chemistry 20010629

• Calmodulin activates intersubunit electron transfer in the neuronal nitric-oxide synthase dimer.

  The Journal of biological chemistry 20010629

• Artificial cytochrome b: computer modeling and evaluation of redox potentials.

  Journal of the American Chemical Society 20010627

• Very high resolution structure of a trematode hemoglobin displaying a TyrB10-TyrE7 heme distal residue pair and high oxygen affinity.

  Journal of molecular biology 20010622

• Carbon monoxide adducts of KatG and KatG(S315T) as probes of the heme site and isoniazid binding.

  Biochemistry 20010619

• Spectral studies of tert-butyl isothiocyanate-inactivated P450 2E1.

  Biochemistry 20010619

• Soret-excited Raman spectroscopy of the spinach cytochrome b6f complex. Structures of the b- and c-type hemes, chlorophyll a, and beta-carotene.

  Biochemistry 20010619

• Site-directed mutagenesis of the heme axial ligands in the hemoflavoenzyme cellobiose dehydrogenase.

  Archives of biochemistry and biophysics 20010615

• Regulation of inducible nitric oxide synthase by self-generated NO.

  Biochemistry 20010612

• Peroxidase self-inactivation in prostaglandin H synthase-1 pretreated with cyclooxygenase inhibitors or substituted with mangano protoporphyrin IX.

  The Journal of biological chemistry 20010608

• Retention of heme in axial ligand mutants of succinate-ubiquinone xxidoreductase (complex II) from Escherichia coli.

  The Journal of biological chemistry 20010601

• Ubiquinol:cytochrome c oxidoreductase (complex III). Effect of inhibitors on cytochrome b reduction in submitochondrial particles and the role of ubiquinone in complex III.

  The Journal of biological chemistry 20010601

• Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme.

  The Journal of biological chemistry 20010601

• Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines.

  American journal of physiology. Gastrointestinal and liver physiology 20010601

• Impaired heme binding and aggregation of mutant cystathionine beta-synthase subunits in homocystinuria.

  American journal of human genetics 20010601

• Normal and abnormal heme biosynthesis. 3.(1)Synthesis and metabolism of tripropionate analogues of coproporphyrinogen-III: novel probes for the active site of coproporphyrinogen oxidase.

  The Journal of organic chemistry 20010601

• Avian haemoglobins and structural basis of high affinity for oxygen: structure of bar-headed goose aquomet haemoglobin.

  Acta crystallographica. Section D, Biological crystallography 20010601

• Vasoregulatory function of the heme-heme oxygenase-carbon monoxide system.

  American journal of hypertension 20010601

• Dimethyl propionate ester heme-containing cytochrome b5: structure and stability.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20010601

• Relaxometric characterization of human hemalbumin.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20010601

• How does heme axial ligand deletion affect the structure and the function of cytochrome b(562)?

  Protein engineering 20010601

• Roles of the proximal heme thiolate ligand in cytochrome p450(cam).

  Journal of the American Chemical Society 20010530

• Binding of ferric heme by the recombinant globin from the cyanobacterium Synechocystis sp. PCC 6803.

  Biochemistry 20010529

• Characterization of Rhodobacter sphaeroides cytochrome c(2) proteins with altered heme attachment sites.

  Archives of biochemistry and biophysics 20010515

• Water penetration and binding to ferric myoglobin.

  Biochemistry 20010515

• Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-gamma-activated human macrophages: posttranslational regulation by pyrrolidine dithiocarbamate.

  Journal of immunology (Baltimore, Md. : 1950) 20010515

• Growth inhibition of Bacteroides fragilis by hemopexin: proteolytic degradation of hemopexin to overcome heme limitation.

  FEMS microbiology letters 20010515

• Solution 1H NMR of the active site of substrate-bound, cyanide-inhibited human heme oxygenase. comparison to the crystal structure of the water-ligated form.

  The Journal of biological chemistry 20010511

• Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.

  Biochemistry 20010508

• The heme-regulated eukaryotic initiation factor 2alpha kinase. A potential regulatory target for control of protein synthesis by diffusible gases.

  The Journal of biological chemistry 20010504

• Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes.

  Biochemical and biophysical research communications 20010504

• Electron transfer from heme bL to the [3Fe-4S] cluster of Escherichia coli nitrate reductase A (NarGHI).

  Biochemistry 20010501

• Electron and proton transfer in the arginine-54-methionine mutant of cytochrome c oxidase from Paracoccus denitrificans.

  Biochemistry 20010501

• A photolysis-triggered heme ligand switch in H93G myoglobin.

  Biochemistry 20010501

• pH-dependent structural changes at the Heme-Copper binuclear center of cytochrome c oxidase.

  Biophysical journal 20010501

• Zinc mesoporphyrin represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria.

  Hepatology (Baltimore, Md.) 20010501

• The role of distal tryptophan in the bifunctional activity of catalase-peroxidases.

  Biochemical Society transactions 20010501

• Engineering the active site of ascorbate peroxidase.

  Biochemical Society transactions 20010501

• Lignin peroxidase structure and function.

  Biochemical Society transactions 20010501

• Spectroscopic investigation and determination of reactivity and structure of the tetraheme cytochrome c3 from Desulfovibrio desulfuricans Essex 6.

  European journal of biochemistry 20010501

• Role of THR501 residue in substrate binding and catalytic activity of cytochrome P4501A1.

  Archives of biochemistry and biophysics 20010501

• Haem arginate interferes with estimation of carcinoembryonic antigen.

  Annals of clinical biochemistry 20010501

• Abortive assembly of succinate-ubiquinone reductase (complex II) in a ferrochelatase-deficient mutant of Escherichia coli.

  Molecular genetics and genomics : MGG 20010501

• Expression and purification of recombinant hemoglobin I from Lucina pectinata.

  Journal of protein chemistry 20010501

• Measurement of heme concentration.

  Current protocols in toxicology 20010501

• Solution structure of Methylophilus methylotrophus cytochrome c': insights into the structural basis of haem-ligand detachment.

  Journal of molecular biology 20010427

• Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A: relevance of heme transfer reactions.

  Biochemistry 20010424

• Structural and dynamic perturbations induced by heme binding in cytochrome b5.

  Biochemistry 20010417

• Prooxidant activity of beta-hematin (synthetic malaria pigment) in arachidonic acid micelles and phospholipid large unilamellar vesicles.

  Biochemical pharmacology 20010415

• Covalently linked heme in cytochrome p4504a fatty acid hydroxylases.

  The Journal of biological chemistry 20010406

• Contribution of the DDDD motif of H. influenzae e (P4) to phosphomonoesterase activity and heme transport.

  FEBS letters 20010406

• Thiouracil antithyroid drugs as a new class of neuronal nitric oxide synthase inhibitors.

  Biochemical and biophysical research communications 20010406

• Resonance Raman studies of cytochrome c' support the binding of NO and CO to opposite sides of the heme: implications for ligand discrimination in heme-based sensors.

  Biochemistry 20010403

• Contributions of prostacyclin and nitric oxide to carbon monoxide-induced cerebrovascular dilation in piglets.

  American journal of physiology. Heart and circulatory physiology 20010401

• Oxygen affinity and amino acid sequence of myoglobins from endothermic and ectothermic fish.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010401

• Trehalose effect on low temperature protein dynamics: fluctuation and relaxation phenomena.

  Biophysical journal 20010401

• Heme oxygenase isoform-specific expression and distribution in the rat kidney.

  Kidney international 20010401

• Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver.

  Gastroenterology 20010401

• The diheme cytochrome b subunit (Narl) of Escherichia coli nitrate reductase A (NarGHI): structure, function, and interaction with quinols.

  Journal of molecular microbiology and biotechnology 20010401

• Isolation and characterization of two peroxidases from Cucumis sativus.

  Archives of biochemistry and biophysics 20010401

• High-resolution structures of the oxidized and reduced states of cytochrome c554 from Nitrosomonas europaea.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20010401

• Redox dependent conformational changes in the mixed valence form of the cytochrome c oxidase from p. The reorganization of glutamic acid 278 is coupled to the electron transfer from/to heme a and the binuclear center. denitrificans.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010401

• Effect of bezafibrate and clofibrate on the heme-iron geometry of ferrous nitrosylated heme-human serum albumin: an EPR study.

  Journal of inorganic biochemistry 20010401

• Spontaneous nucleophilic addition of hydroxide ions to the meso-position of high-valent antimony-oxo porphyrin complexes.

  Journal of inorganic biochemistry 20010401

• [Effect of glutamate on spontaneous secretion of acetylcholine in the nerve-muscle synapse in rats].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20010401

• Developmental profile, isolation, and biochemical characterization of a novel lipoglycoheme-carrier protein from the American dog tick, Dermacentor variabilis (Acari: Ixodidae) and observations on a similar protein in the soft tick, Ornithodoros parkeri (Acari: Argasidae).

  Insect biochemistry and molecular biology 20010315

• Heme biosynthesis and oogenesis in the blood-sucking bug, Rhodnius prolixus.

  Insect biochemistry and molecular biology 20010315

• Uroporphyrinogen III synthase erythroid promoter mutations in adjacent GATA1 and CP2 elements cause congenital erythropoietic porphyria.

  The Journal of clinical investigation 20010315

• Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges.

  Journal of medicinal chemistry 20010315

• Redox properties and coordination structure of the heme in the co-sensing transcriptional activator CooA.

  The Journal of biological chemistry 20010309

• Active site structure of the catalase-peroxidases from Mycobacterium tuberculosis and Escherichia coli by extended X-ray absorption fine structure analysis.

  Biochimica et biophysica acta 20010309

• NO-independent regulatory site on soluble guanylate cyclase.

  Nature 20010308

• Recombinant cytochrome rC557 obtained from Escherichia coli cells expressing a truncated Thermus thermophilus cycA gene. Heme inversion in an improperly matured protein.

  The Journal of biological chemistry 20010302

• Ligand migration in human myoglobin: steric effects of isoleucine 107(G8) on O(2) and CO binding.

  Biophysical journal 20010301

• Turning green to gold.

  Nature structural biology 20010301

• Crystal structure of rat biliverdin reductase.

  Nature structural biology 20010301

• Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease.

  The American journal of pathology 20010301

• Expression of coproporphyrinogen oxidase and synthesis of hemoglobin in human erythroleukemia K562 cells.

  European journal of biochemistry 20010301

• Haemoproteus and Schistosoma synthesize heme polymers similar to Plasmodium hemozoin and beta-hematin.

  Molecular and biochemical parasitology 20010301

• Is delta-aminolevulinic acid dehydratase rate limiting in heme biosynthesis following exposure of cells to delta-aminolevulinic acid?

  Photochemistry and photobiology 20010301

• A novel copper A containing menaquinol NO reductase from Bacillus azotoformans.

  Biochemistry 20010227

• CCME, a nuclear-encoded heme-binding protein involved in cytochrome c maturation in plant mitochondria.

  The Journal of biological chemistry 20010223

• Chromaffin granule membranes contain at least three heme centers: direct evidence from EPR and absorption spectroscopy.

  FEBS letters 20010223

• Photoinduced electron transfer in the cytochrome c/cytochrome c oxidase complex using thiouredopyrenetrisulfonate-labeled cytochrome c. Optical multichannel detection.

  Biochemistry 20010220

• Characterization of the coral allene oxide synthase active site with UV-visible absorption, magnetic circular dichroism, and electron paramagnetic resonance spectroscopy: evidence for tyrosinate ligation to the ferric enzyme heme iron.

  Biochemistry 20010220

• Mapping the pathways for O2 entry into and exit from myoglobin.

  The Journal of biological chemistry 20010216

• A positively charged cluster formed in the heme-distal pocket of cytochrome P450nor is essential for interaction with NADH.

  The Journal of biological chemistry 20010216

• Expression, purification, and characterization of human hemoglobins Gower-1 (zeta(2)epsilon(2)), Gower-2 (alpha(2)epsilon(2)), and Portland-2 (zeta(2)beta(2)) assembled in complex transgenic-knockout mice.

  Blood 20010215

• Administration of heme arginate, but not hematin, caused anaphylactic shock.

  The American journal of medicine 20010215

• The heme-globin and dimerization equilibria of recombinant human hemoglobins carrying site-specific beta chains mutations.

  Archives of biochemistry and biophysics 20010215

• Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.

  Biochemistry 20010206

• Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 2. Effects on heme coordination and function.

  Biochemistry 20010206

• Rate of intrachain contact formation in an unfolded protein: temperature and denaturant effects.

  Journal of molecular biology 20010202

• Molecular dynamics simulation of carboxy-myoglobin embedded in a trehalose-water matrix.

  Biophysical journal 20010201

• Inhibition of neuronal nitric oxide synthase by N-phenacyl imidazoles.

  Nitric oxide : biology and chemistry 20010201

• Mutagenesis of key residues identifies the connection subdomain of HIV-1 reverse transcriptase as the site of inhibition by heme.

  European journal of biochemistry 20010201

• Design, synthesis, and characterization of a novel hemoprotein.

  Protein science : a publication of the Protein Society 20010201

• Antioxidant treatment inhibits activation of myocardial nuclear factor kappa B and inhibits nitrosylation of myocardial heme protein in cardiac transplant rejection.

  Antioxidants & redox signaling 20010201

• Synthetic active site analogues of heme-thiolate proteins. Characterization and identification of intermediates of the catalytic cycles of cytochrome P450cam and chloroperoxidase.

  Journal of inorganic biochemistry 20010201

• A proximal tryptophan in NO synthase controls activity by a novel mechanism.

  Journal of inorganic biochemistry 20010201

• Effects of reduction and ligation of heme iron on the thermal stability of heme-hemopexin complexes.

  Journal of protein chemistry 20010201

• Crystal structures of pristine and oxidatively processed lignin peroxidase expressed in Escherichia coli and of the W171F variant that eliminates the redox active tryptophan 171. Implications for the reaction mechanism.

  Journal of molecular biology 20010126

• NMR structure of the haem core of a novel tetrahaem cytochrome isolated from Shewanella frigidimarina: identification of the haem-specific axial ligands and order of oxidation.

  FEBS letters 20010126

• Resonance Raman characterization of the heme cofactor in cystathionine beta-synthase. Identification of the Fe-S(Cys) vibration in the six-coordinate low-spin heme.

  Biochemistry 20010116

• Haem regulation of the mitochondrial import of the Kluyveromyces lactis 5-aminolaevulinate synthase: an organelle approach.

  Yeast (Chichester, England) 20010115

• Haem-linked interactions in horseradish peroxidase revealed by spectroscopic analysis of the Phe-221-->Met mutant.

  The Biochemical journal 20010115

• Role of LYS271 and LYS279 residues in the interaction of cytochrome P4501A1 with NADPH-cytochrome P450 reductase.

  Archives of biochemistry and biophysics 20010115

• The kinetic and spectral characterization of the E. coli-expressed mammalian CYP4A7: cytochrome b5 effects vary with substrate.

  Archives of biochemistry and biophysics 20010115

• Neuronal nitric-oxide synthase mutant (Ser-1412 --> Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis.

  The Journal of biological chemistry 20010112

• A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase.

  The Journal of biological chemistry 20010112

• Kinetic evidence for surface residues influencing the active site of Coprinus cinereus peroxidase: analysis of the pH dependence of G154E, P90H and P90H-G154E substrate entrance mutants.

  Biochimica et biophysica acta 20010112

• Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase.

  The Journal of biological chemistry 20010105

• Reconstitution of pterin-free inducible nitric-oxide synthase.

  The Journal of biological chemistry 20010105

• Effect of heme iron valence state on the conformation of cytochrome c and its association with membrane interfaces. A CD and EPR investigation.

  The Journal of biological chemistry 20010105

• Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase.

  The Journal of biological chemistry 20010105

• Functional properties of the active core of human cystathionine beta-synthase crystals.

  The Journal of biological chemistry 20010105

• Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site.

  Drug metabolism and disposition: the biological fate of chemicals 20010101

• Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme.

  Molecular pharmacology 20010101

• Hydroxyurea-induced oxidative damage of normal and sickle cell hemoglobins in vitro: amelioration by radical scavengers.

  Journal of clinical laboratory analysis 20010101

• Hemin (Fe(3+))-- and heme (Fe(2+))--smectite conjugates as a model of hemoprotein based on spectrophotometry.

  Bioconjugate chemistry 20010101

• Nitrate respiratory metabolism in an obligately autotrophic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus TK-6.

  Archives of microbiology 20010101

• Non-enzymatic reduction of aliphatic tertiary amine N-oxides mediated by the haem moiety of cytochrome P450.

  Xenobiotica; the fate of foreign compounds in biological systems 20010101

• ABC transporter-mediated uptake of iron, siderophores, heme and vitamin B12.

  Research in microbiology 20010101

• [Oxidation of indole and its derivatives by heme-independent chloroperoxidases].

  Prikladnaia biokhimiia i mikrobiologiia 20010101

• [Changes in the activity of enzymes of heme synthesis and catabolism, and level of microsomal hemoproteins during the liver acute intoxication by thioacetamide].

  Voprosy meditsinskoi khimii 20010101

• Photoreduction of autooxidized albumin-heme hybrid in saline solution: revival of its O(2)-binding ability.

  Bioconjugate chemistry 20010101

• [Morphofunctional characteristics of erythron (review of the literature)].

  Klinicheskaia laboratornaia diagnostika 20010101

• Modification of the heme electronic structure induced by complex formation with nitric oxide and the atomic backbone dynamics at room temperature.

  Doklady. Biochemistry and biophysics 20010101

• Loss of charged versus neutral heme from gaseous holomyoglobin ions.

  Rapid communications in mass spectrometry : RCM 20010101

• Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site.

  Advances in experimental medicine and biology 20010101

• Anaerobic growth of Saccharomyces cerevisiae alleviates the lethal effect of phosphotyrosyl phosphatase activators depletion.

  Acta biochimica Polonica 20010101

• [The antimalarial mechanism of artemisinin and its derivatives].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20010101

• Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donors.

  Gut 20001201

• A key role for the mitochondrial benzodiazepine receptor in cellular photosensitisation with delta-aminolaevulinic acid.

  European journal of pharmacology 20001013

• Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor.

  The Journal of biological chemistry 20000908

• Induction of the heme oxygenase-1 gene by metalloporphyrins.

  Archives of biochemistry and biophysics 20000815

• Erythropoietin induction in Hep3B cells is not affected by inhibition of heme biosynthesis.

  Biochimica et biophysica acta 20000227

• Novel heme-containing lyase, phenylacetaldoxime dehydratase from Bacillus sp. strain OxB-1: purification, characterization, and molecular cloning of the gene.

  Biochemistry 20000201

• The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties.

  Free radical biology & medicine 20000115

• Role for copper in transient oxidation and nuclear translocation of MTF-1, but not of NF-kappa B, by the heme-hemopexin transport system.

  Antioxidants & redox signaling 20000101

• Spectroscopic characterization of the heme-binding sites in Plasmodium falciparum histidine-rich protein 2.

  Biochemistry 19991221

• Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution.

  Nature 19991125

• Deconstructing heme.

  Nature structural biology 19991001

• Disruption of myoglobin in mice induces multiple compensatory mechanisms.

  Proceedings of the National Academy of Sciences of the United States of America 19990831

• Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of delta-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats.

  Biochemical pharmacology 19990815

• Structure of cytochrome c nitrite reductase.

  Nature 19990729

• Cyclooxygenase dependent release of heme from microsomal hemeproteins correlates with induction of heme oxygenase 1 transcription in human fibroblasts.

  Free radical biology & medicine 19990301

• Non-iron metalloporphyrins: potent antibacterial compounds that exploit haem/Hb uptake systems of pathogenic bacteria.

  Molecular microbiology 19990101

• Functional properties of a naturally occurring isoform of soluble guanylyl cyclase.

  The Biochemical journal 19981001

• Enhancement of estrogen-induced renal tumorigenesis in hamsters by dietary iron.

  Carcinogenesis 19980701

• Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases.

  The Journal of biological chemistry 19980410

• Role of H2O2 and heme-containing O2 sensors in hypoxic regulation of tyrosine hydroxylase gene expression.

  The American journal of physiology 19980101

• Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase.

  British journal of pharmacology 19980101

• Regulation of expression of the human heme oxygenase-1 gene in transfected chick embryo liver cell cultures.

  Biochimica et biophysica acta 19970626

• Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response.

  Molecular and cellular biochemistry 19970401

• Regulation of CYP 2 A 5 induction by porphyrinogenic agents in mouse primary hepatocytes.

  Naunyn-Schmiedeberg's archives of pharmacology 19970101

• Preparation and reactions of myoglobin mutants bearing both proximal cysteine ligand and hydrophobic distal cavity: protein models for the active site of P-450.

  Biochemistry 19961008

• The heme-responsive element of the mouse heme oxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for MAF and NF-E2 transcription factors.

  Biochemical and biophysical research communications 19960425

• Reductive activation of 1,1-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital- and pyridine-induced rat liver microsomal cytochrome P450.

  Xenobiotica; the fate of foreign compounds in biological systems 19960401

• Inhibition of human immunodeficiency virus-1 reverse transcriptase by heme and synthetic heme analogs.

  Proceedings of the Association of American Physicians 19960101

• Identification of a second region upstream of the mouse heme oxygenase-1 gene that functions as a basal level and inducer-dependent transcription enhancer.

  The Journal of biological chemistry 19950519

• STZ-induced diabetes in mice and heme pathway enzymes. Effect of allylisopropylacetamide and alpha-tocopherol.

  Chemico-biological interactions 19950414

• Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.

  Naunyn-Schmiedeberg's archives of pharmacology 19950401

• Aromatic substrate molecules bind at the distal heme pocket of myeloperoxidase.

  The Journal of biological chemistry 19940318

• Identification of a cytochrome P450 gene by reverse transcription--PCR using degenerate primers containing inosine.

  Proceedings of the National Academy of Sciences of the United States of America 19931215

• Additive effect of erythropoietin and heme on murine hematopoietic recovery after azidothymidine treatment.

  Blood 19931215

• Ro 09-1470 is a selective inhibitor of P-450 lanosterol C-14 demethylase of fungi.

  Antimicrobial agents and chemotherapy 19931201

• Long-term bone marrow stromal and hemopoietic toxicity to AZT: protective role of heme and IL-1.

  Experimental hematology 19930201

• The influence of mannitol on myoglobinuric acute renal failure: functional, biochemical, and morphological assessments.

  Journal of the American Society of Nephrology : JASN 19911001

• Heme inhibits human immunodeficiency virus 1 replication in cell cultures and enhances the antiviral effect of zidovudine.

  Proceedings of the National Academy of Sciences of the United States of America 19910301

• High-level expression of Escherichia coli NADPH-sulfite reductase: requirement for a cloned cysG plasmid to overcome limiting siroheme cofactor.

  Journal of bacteriology 19910101

• Pharmacokinetics of tin-mesoporphyrin in man and the effects of tin-chelated porphyrins on hyperexcretion of heme pathway precursors in patients with acute inducible porphyria.

  Hepatology (Baltimore, Md.) 19890601

• Depletion of liver regulatory heme in benzene exposed rats.

  Toxicology 19880301

• Interaction of heme with a synthetic peptide mimicking the putative heme-binding site of histidine-rich glycoprotein.

  Biochemical and biophysical research communications 19871231

• Structure and regulation of eukaryotic initiation factor eIF-2. Sequence of the site in the alpha subunit phosphorylated by the haem-controlled repressor and by the double-stranded RNA-activated inhibitor.

  European journal of biochemistry 19870715

• Carbamazepine-induced non-hereditary acute porphyria.

  Lancet (London, England) 19830409

• Selective inhibition of delta-aminolevulinic acid dehydratase by indium chloride in rat kidney: biochemical and ultrastructural studies.

  Experimental and molecular pathology 19820601

• Effect of Griseofulvin on 5-aminolevulinate synthase and on ferrochelatase in mouse liver neoplastic nodules.

  Cancer research 19810401

• The effect of chloramphenicol on erythropoiesis in X-irradiated mice.

  Chemotherapy 19810101

• Haem synthesis in sideroblastic anaemia.

  British journal of haematology 19790501

• Reversal of ineffective erythropoiesis in pernicious anaemia following vitamin B12 therapy.

  British journal of haematology 19770201

• Red cell aplasia following prolonged D-penicillamine therapy.

  Journal of clinical pathology 19760201

• Studies on cytochrome oxidase. Partial resolution of enzymes containing seven or six subunits, from yeast and beef heart, respectively.

  The Journal of biological chemistry 19760125

• Proceedings: Proton magnetic relaxation of some high spin hemoproteins in aqueous solutions.

  Israel journal of medical sciences 19751101

• Effects of chlorpromazine on bilirubin metabolism and biliary secretion in the rat.

  Gastroenterology 19751001

• Commentary: the year in nuclear receptor control of metabolism.

  Molecular endocrinology (Baltimore, Md.)