149647-78-9 | N-hydroxy-N'-phenyloctanediamide

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$33.00	$23.00
1g	98%	in stock	$62.00	$44.00
5g	98%	in stock	$171.00	$120.00
25g	98%	in stock	$480.00	$336.00

Description

• Catalog Number: AB50225
• Chemical Name: N-hydroxy-N'-phenyloctanediamide
• CAS Number: 149647-78-9
• Molecular Formula: C14H20N2O3
• Molecular Weight: 264.3202
• MDL Number: MFCD00945317
• SMILES: ONC(=O)CCCCCCC(=O)Nc1ccccc1

Computed Properties

• Complexity: 276
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 19
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 8
• XLogP3: 1.9

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  International journal of breast cancer 20120101

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  Journal of oncology 20120101

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  Neoplasma 20120101

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• Novel Insights into the Interplay between Apoptosis and Autophagy.

  International journal of cell biology 20120101

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• Activating Death Receptor DR5 as a Therapeutic Strategy for Rhabdomyosarcoma.

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  Journal of neuroinflammation 20120101

• Epigenetics modifications and therapeutic prospects in human thyroid cancer.

  Frontiers in endocrinology 20120101

• Acute myeloid leukemia: focus on novel therapeutic strategies.

  Clinical Medicine Insights. Oncology 20120101

• Analyzing gene expression profile in K562 cells exposed to sodium valproate using microarray combined with the connectivity map database.

  Journal of biomedicine & biotechnology 20120101

• Valproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cells.

  Journal of biomedicine & biotechnology 20120101

• Targeted therapies in sarcomas: challenging the challenge.

  Sarcoma 20120101

• Adult T-cell leukemia/lymphoma: a retroviral malady.

  Indian journal of dermatology 20120101

• QT interval prolongation and torsades de pointes in a patient undergoing treatment with vorinostat: a case report and review of the literature.

  Cardiology journal 20120101

• The effect of vorinostat on the development of resistance to doxorubicin in neuroblastoma.

  PloS one 20120101

• A novel class of anti-HIV agents with multiple copies of enfuvirtide enhances inhibition of viral replication and cellular transmission in vitro.

  PloS one 20120101

• Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression.

  BMC urology 20120101

• Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines.

  PloS one 20120101

• Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma.

  Radiation oncology (London, England) 20120101

• [Multikinase inhibitor sorafenib and HDAC inhibitor suberoylanilide hydroxamic acid suppress confluent resistance of cancer cells to recombinant protein izTRAIL].

  Biofizika 20120101

• Mechanisms of resistance to histone deacetylase inhibitors.

  Advances in cancer research 20120101

• Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents.

  Bioorganic & medicinal chemistry letters 20111215

• Histone deacetylase inhibitors: emerging mechanisms of resistance.

  Molecular pharmaceutics 20111205

• Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro.

  Journal of cellular physiology 20111201

• Grand rounds at the National Institutes of Health: HDAC inhibitors as radiation modifiers, from bench to clinic.

  Journal of cellular and molecular medicine 20111201

• SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis.

  Cell death and differentiation 20111201

• Efficacy and safety of the third-generation chloroethylnitrosourea fotemustine for the treatment of chemorefractory T-cell lymphomas.

  European journal of haematology 20111201

• Antitumor activity of a novel histone deacetylase inhibitor (S)-HDAC42 in oral squamous cell carcinoma.

  Oral oncology 20111201

• MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells.

  Endocrine-related cancer 20111201

• Identification of selective class II histone deacetylase inhibitors using a novel dual-parameter binding assay based on fluorescence anisotropy and lifetime.

  Journal of biomolecular screening 20111201

• A new target for personalized medicine.

  EMBO reports 20111201

• Diagnostic and prognostic markers in differentiated thyroid cancer.

  Current genomics 20111201

• miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells.

  The Journal of biological chemistry 20111125

• Reversible molecular pathology of skeletal muscle in spinal muscular atrophy.

  Human molecular genetics 20111115

• Enhanced suppression of tumor growth by concomitant treatment of human lung cancer cells with suberoylanilide hydroxamic acid and arsenic trioxide.

  Toxicology and applied pharmacology 20111115

• 4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors.

  Bioorganic & medicinal chemistry letters 20111115

• Determination of HS270, a new histone deacetylase inhibitor, in rat plasma by LC-MS/MS--application to a preclinical pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111115

• Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.

  Journal of medicinal chemistry 20111110

• Design, synthesis and biological evaluation of hydroxamic acid derivatives as potential high density lipoprotein (HDL) receptor CLA-1 up-regulating agents.

  Molecules (Basel, Switzerland) 20111102

• Addition of a histone deacetylase inhibitor redirects tamoxifen-treated breast cancer cells into apoptosis, which is opposed by the induction of autophagy.

  Breast cancer research and treatment 20111101

• STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction.

  Inflammatory bowel diseases 20111101

• A 5-aza-2'-deoxycytidine/valproate combination induces cytotoxic T-cell response against mesothelioma.

  The European respiratory journal 20111101

• Vorinostat modulates cell cycle regulatory proteins in glioma cells and human glioma slice cultures.

  Journal of neuro-oncology 20111101

• Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and clinical outcomes in Asian women with breast cancer.

  Pharmacogenetics and genomics 20111101

• A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat.

  Acta neuropathologica 20111101

• HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes.

  Journal of lipid research 20111101

• Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma.

  Molecular cancer therapeutics 20111101

• Unexpected high levels of vorinostat when combined with vinorelbine in patients with advanced cancer.

  Current clinical pharmacology 20111101

• Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.

  Journal of natural products 20111028

• p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia.

  The Journal of biological chemistry 20111028

• The use of molecular profiling for diagnosis and research in non-Hodgkin's lymphoma.

  Hematology reports 20111028

• The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.

  Bioorganic & medicinal chemistry letters 20111015

• Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug.

  Journal of controlled release : official journal of the Controlled Release Society 20111010

• Synergistic induction of apoptosis in brain cancer cells by targeted codelivery of siRNA and anticancer drugs.

  Molecular pharmaceutics 20111003

• A phase I pharmacokinetic study of pulse-dose vorinostat with flavopiridol in solid tumors.

  Investigational new drugs 20111001

• Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.

  Cancer 20111001

• Vorinostat, SAHA, represses telomerase activity via epigenetic regulation of telomerase reverse transcriptase in non-small cell lung cancer cells.

  Journal of cellular biochemistry 20111001

• Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling.

  American journal of physiology. Cell physiology 20111001

• Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds.

  Current cancer drug targets 20111001

• MCF10A and MDA-MB-231 human breast basal epithelial cell co-culture in silicon micro-arrays.

  Biomaterials 20111001

• SAHA Capture Compound--a novel tool for the profiling of histone deacetylases and the identification of additional vorinostat binders.

  Proteomics 20111001

• Analysis of apoptosis regulatory genes altered by histone deacetylase inhibitors in chronic lymphocytic leukemia cells.

  Epigenetics 20111001

• Prevention of mouse lung tumors by combinations of chemopreventive agents using concurrent and sequential administration.

  Anticancer research 20111001

• Vitamin D deficiency in a man with multiple myeloma.

  North American journal of medical sciences 20111001

• Disruption of IkappaB kinase (IKK)-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to histone deacetylase (HDAC) inhibitors.

  The Journal of biological chemistry 20110930

• Discovery, synthesis, and biological evaluation of novel SMN protein modulators.

  Journal of medicinal chemistry 20110922

• Chemotherapy and targeted therapies for unresectable malignant mesothelioma.

  Lung cancer (Amsterdam, Netherlands) 20110901

• Vorinostat induced cellular stress disrupts the p38 mitogen activated protein kinase and extracellular signal regulated kinase pathways leading to apoptosis in Waldenström macroglobulinemia cells.

  Leukemia & lymphoma 20110901

• HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT.

  Journal of cellular physiology 20110901

• HDAC inhibitors potentiate the apoptotic effect of enzastaurin in lymphoma cells.

  Apoptosis : an international journal on programmed cell death 20110901

• Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor.

  Cancer chemotherapy and pharmacology 20110901

• Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.

  European journal of medicinal chemistry 20110901

• Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target.

  Human reproduction (Oxford, England) 20110901

• Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo.

  Molecular cancer therapeutics 20110901

• Proteomic analysis identifies differentially expressed proteins after HDAC vorinostat and EGFR inhibitor gefitinib treatments in Hep-2 cancer cells.

  Proteomics 20110901

• Targeting Waldenstrom macroglobulinemia with histone deacetylase inhibitors.

  Leukemia & lymphoma 20110901

• Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock.

  Surgery 20110901

• Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities.

  Journal of medicinal chemistry 20110811

• In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).

  Journal of medicinal chemistry 20110811

• Antitumor effects of (S)-HDAC42, a phenylbutyrate-derived histone deacetylase inhibitor, in multiple myeloma cells.

  Cancer chemotherapy and pharmacology 20110801

• Cytotoxicity and genotoxicity of capecitabine in head and neck cancer and normal cells.

  Molecular biology reports 20110801

• Effects and mechanisms of the combination of suberoylanilide hydroxamic acid and bortezomib on the anticancer property of gemcitabine in pancreatic cancer.

  Pancreas 20110801

• Histone deacetylase inhibitors induce thymidine phosphorylase expression in cultured breast cancer cell lines.

  Oncology reports 20110801

• Structure-based optimization of click-based histone deacetylase inhibitors.

  European journal of medicinal chemistry 20110801

• Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110801

• Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors.

  Neuro-oncology 20110801

• Romidepsin: a novel histone deacetylase inhibitor for cancer.

  Expert opinion on investigational drugs 20110801

• Design, synthesis and biological evaluation of tyrosine-based hydroxamic acid analogs as novel histone deacetylases (HDACs) inhibitors.

  Bioorganic & medicinal chemistry 20110801

• [Histone deacetylase inhibitors in the treatment of hematological malignancies].

  Bulletin du cancer 20110801

• [Development of novel agents for multiple myeloma; now and the future].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20110801

• [Present status and perspective of targeted therapy for B-cell lymphoma].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20110801

• Subcutaneous panniculitis-like T-cell lymphoma: a clinical and pathologic study of 14 korean patients.

  Annals of dermatology 20110801

• Epigenetic treatment of neurological disease.

  Epigenomics 20110801

• Epigenetic regulation of prostate cancer.

  Clinical epigenetics 20110801

• Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies.

  Clinical epigenetics 20110801

• Targeting Huntington's disease through histone deacetylases.

  Clinical epigenetics 20110801

• Epigenetic approaches in stem cell transplantation.

  Clinical epigenetics 20110801

• Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms.

  Cancer letters 20110728

• Vaccination with epigenetically treated mesothelioma cells induces immunisation and blocks tumour growth.

  Vaccine 20110726

• A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.

  Bioorganic & medicinal chemistry letters 20110715

• Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.

  Journal of medicinal chemistry 20110714

• Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.

  Journal of medicinal chemistry 20110714

• Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.

  Journal of medicinal chemistry 20110714

• Combination of vorinostat and adenovirus-TRAIL exhibits a synergistic antitumor effect by increasing transduction and transcription of TRAIL in lung cancer cells.

  Cancer gene therapy 20110701

• Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.

  Cancer research 20110701

• The synthesis and evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), a PET radiotracer designed for the delineation of histone deacetylase expression in cancer.

  Nuclear medicine and biology 20110701

• [Epigenetic therapy in myelodysplastic syndromes].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20110701

• Efficient organic monoliths prepared by γ-radiation induced polymerization in the evaluation of histone deacetylase inhibitors by capillary(nano)-high performance liquid chromatography and ion trap mass spectrometry.

  Journal of chromatography. A 20110624

• Epigenetic profiling of the antitumor natural product psammaplin A and its analogues.

  Bioorganic & medicinal chemistry 20110615

• Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs).

  Bioorganic & medicinal chemistry 20110615

• Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110615

• A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer.

  British journal of cancer 20110607

• Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.

  Neuropathology and applied neurobiology 20110601

• Leukemia cutis in association With Grover's disease.

  The American Journal of dermatopathology 20110601

• Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor.

  Kidney international 20110601

• Suberoylanilide hydroxamic acid, a potent histone deacetylase inhibitor; its X-ray crystal structure and solid state and solution studies of its Zn(II), Ni(II), Cu(II) and Fe(III) complexes.

  Journal of inorganic biochemistry 20110601

• Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.

  Cancer research 20110601

• Metabolism as a key to histone deacetylase inhibition.

  Critical reviews in biochemistry and molecular biology 20110601

• HDAC1 inhibition by maspin abrogates epigenetic silencing of glutathione S-transferase pi in prostate carcinoma cells.

  Molecular cancer research : MCR 20110601

• Myeloproliferative neoplasms: from JAK2 mutations discovery to JAK2 inhibitor therapies.

  Oncotarget 20110601

• Clinical development of panobinostat in classical Hodgkin's lymphoma.

  Expert review of hematology 20110601

• SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.

  PLoS genetics 20110601

• Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737.

  Cancer research 20110515

• HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110515

• Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.

  The Journal of biological chemistry 20110506

• Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts.

  Bone 20110501

• Discovery of histone deacetylase 8 selective inhibitors.

  Bioorganic & medicinal chemistry letters 20110501

• Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism.

  The American journal of pathology 20110501

• Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.

  Journal of medicinal chemistry 20110428

• Development of tetrahydroisoquinoline-based hydroxamic acid derivatives: potent histone deacetylase inhibitors with marked in vitro and in vivo antitumor activities.

  Journal of medicinal chemistry 20110428

• Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.

  Bioorganic & medicinal chemistry letters 20110415

• Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110415

• Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.

  Journal of medicinal chemistry 20110414

• The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110401

• Decitabine-induced apoptosis is derived by Puma and Noxa induction in chronic myeloid leukemia cell line as well as in PBL and is potentiated by SAHA.

  Molecular and cellular biochemistry 20110401

• The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.

  British journal of pharmacology 20110401

• Loss of RUNX3 expression by histone deacetylation is associated with biliary tract carcinogenesis.

  Cancer science 20110401

• KRAS-mutated non-small cell lung cancer cells are responsive to either co-treatment with erlotinib or gefitinib and histone deacetylase inhibitors or single treatment with lapatinib.

  Oncology reports 20110401

• Differentiation of NUT midline carcinoma by epigenomic reprogramming.

  Cancer research 20110401

• The efficacy of vorinostat in combination with interferon alpha and extracorporeal photopheresis in late stage mycosis fungoides and Sezary syndrome.

  Journal of drugs in dermatology : JDD 20110401

• Phase II study of vorinostat for treatment of relapsed or refractory indolent non-Hodgkin's lymphoma and mantle cell lymphoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110320

• Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110315

• Potentiation of apoptosis by histone deacetylase inhibitors and doxorubicin combination: cytoplasmic cathepsin B as a mediator of apoptosis in multiple myeloma.

  British journal of cancer 20110315

• Pretreatment with anti-oxidants sensitizes oxidatively stressed human cancer cells to growth inhibitory effect of suberoylanilide hydroxamic acid (SAHA).

  Cancer chemotherapy and pharmacology 20110301

• The emerging role of histone deacetylase inhibitors in treating T-cell lymphomas.

  Current hematologic malignancy reports 20110301

• Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation.

  Leukemia 20110301

• HDAC inhibitors downregulate MRP2 expression in multidrug resistant cancer cells: implication for chemosensitization.

  International journal of oncology 20110301

• 1,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer.

  The Journal of steroid biochemistry and molecular biology 20110301

• Phase I clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours.

  British journal of cancer 20110301

• New drug therapies in peripheral T-cell lymphoma.

  Expert review of anticancer therapy 20110301

• Epigenetics in cancer: what's the future?

  Oncology (Williston Park, N.Y.) 20110301

• [Design, synthesis, and biological activities of histone deacetylase inhibitors with diketo ester as zinc binding group].

  Yao xue xue bao = Acta pharmaceutica Sinica 20110301

• Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis.

  The Journal of biological chemistry 20110225

• Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2.

  Biochemical pharmacology 20110215

• Histone deacetylase inhibitors as a tool to up-regulate new fungal biosynthetic products: isolation of EGM-556, a cyclodepsipeptide, from Microascus sp.

  Organic letters 20110204

• Vorinostat in acute myeloid leukemia and myelodysplastic syndromes.

  Expert opinion on investigational drugs 20110201

• Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer.

  Future oncology (London, England) 20110201

• Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts.

  Cell death & disease 20110201

• Therapeutic advances in cutaneous T-cell lymphoma.

  Skin therapy letter 20110201

• Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events.

  Neuron 20110127

• Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors.

  Analytical biochemistry 20110115

• Acetylation of EGF receptor contributes to tumor cell resistance to histone deacetylase inhibitors.

  Biochemical and biophysical research communications 20110107

• Synthetic lethality: general principles, utility and detection using genetic screens in human cells.

  FEBS letters 20110103

• Identification of genes associated with chemosensitivity to SAHA/taxane combination treatment in taxane-resistant breast cancer cells.

  Breast cancer research and treatment 20110101

• Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases.

  Molecular pharmacology 20110101

• Identification of clinically used drugs that activate pregnane X receptors.

  Drug metabolism and disposition: the biological fate of chemicals 20110101

• The Role of Allogeneic Stem Cell Transplantation in Relapsed/Refractory Hodgkin's Lymphoma Patients.

  Advances in hematology 20110101

• Rationale for possible targeting of histone deacetylase signaling in cancer diseases with a special reference to pancreatic cancer.

  Journal of biomedicine & biotechnology 20110101

• Epigenetic modulation of gene expression of human leukemia cell lines - induction of cell death and senescence.

  Neoplasma 20110101

• Roles and targets of class I and IIa histone deacetylases in cardiac hypertrophy.

  Journal of biomedicine & biotechnology 20110101

• Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.

  Journal of biomedicine & biotechnology 20110101

• Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors.

  Journal of biomedicine & biotechnology 20110101

• Manipulating protein acetylation in breast cancer: a promising approach in combination with hormonal therapies?

  Journal of biomedicine & biotechnology 20110101

• Psorinum therapy in treating stomach, gall bladder, pancreatic, and liver cancers: a prospective clinical study.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2.

  Journal of biomedicine & biotechnology 20110101

• Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay.

  Journal of biomedicine & biotechnology 20110101

• Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors.

  Silence 20110101

• HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter.

  Journal of biomedicine & biotechnology 20110101

• Finding a cure for HIV: will it ever be achievable?

  Journal of the International AIDS Society 20110101

• Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks.

  Genome integrity 20110101

• The role of HDACs inhibitors in childhood and adolescence acute leukemias.

  Journal of biomedicine & biotechnology 20110101

• Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis.

  PloS one 20110101

• Inhibition of histone deacetylases 1 and 6 enhances cytarabine-induced apoptosis in pediatric acute myeloid leukemia cells.

  PloS one 20110101

• C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo.

  Cell death & disease 20110101

• Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs.

  American journal of translational research 20110101

• Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin.

  Epigenetics & chromatin 20110101

• Histone deacetylase inhibitors for purging HIV-1 from the latent reservoir.

  Molecular medicine (Cambridge, Mass.) 20110101

• HDAC inhibition decreases the expression of EGFR in colorectal cancer cells.

  PloS one 20110101

• Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma.

  Core evidence 20110101

• Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapy.

  Radiation oncology (London, England) 20110101

• Identification of common differentially expressed genes in urinary bladder cancer.

  PloS one 20110101

• Apoptotic sphingolipid ceramide in cancer therapy.

  Journal of lipids 20110101

• p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin.

  PloS one 20110101

• Antitumor effect of suberoylanilide hydroxamic acid and topotecan in renal cancer cells.

  Oncology research 20110101

• Critical appraisal of nilotinib in frontline treatment of chronic myeloid leukemia.

  Cancer management and research 20110101

• Selectivity of Inhibition of N-Succinyl-l,l-Diaminopimelic Acid Desuccinylase in Bacteria: The product of dapE-gene Is Not the Target of l-Captopril Antimicrobial Activity.

  Bioinorganic chemistry and applications 20110101

• Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells.

  BMC neuroscience 20110101

• Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.

  Molecular cancer 20110101

• Interpreting clinical assays for histone deacetylase inhibitors.

  Cancer management and research 20110101

• Autophagic and apoptotic effects of HDAC inhibitors on cancer cells.

  Journal of biomedicine & biotechnology 20110101

• Myelodysplastic syndrome and histone deacetylase inhibitors: 'to be or not to be acetylated'?

  Journal of biomedicine & biotechnology 20110101

• Emerging role of carfilzomib in treatment of relapsed and refractory lymphoid neoplasms and multiple myeloma.

  Core evidence 20110101

• Epigenetic changes in cancer.

  F1000 biology reports 20110101

• Vorinostat induces reactive oxygen species and DNA damage in acute myeloid leukemia cells.

  PloS one 20110101

• Promising molecular targeted therapies in breast cancer.

  Indian journal of pharmacology 20110101

• Epigenetic predictor of age.

  PloS one 20110101

• Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors.

  Journal of biomedicine & biotechnology 20110101

• A pharmacogenomic method for individualized prediction of drug sensitivity.

  Molecular systems biology 20110101

• Synergistic activity of ixabepilone plus other anticancer agents: preclinical and clinical evidence.

  Therapeutic advances in medical oncology 20110101

• Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells.

  PloS one 20110101

• The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells.

  Cancer cell international 20110101

• Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90.

  Molecular cancer 20110101

• The biology of HDAC in cancer: the nuclear and epigenetic components.

  Handbook of experimental pharmacology 20110101

• Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells.

  PloS one 20110101

• Latency profiles of full length HIV-1 molecular clone variants with a subtype specific promoter.

  Retrovirology 20110101

• The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway.

  PloS one 20110101

• Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer.

  PloS one 20110101

• Combination of suberoylanilide hydroxamic acid with heavy ion therapy shows promising effects in infantile sarcoma cell lines.

  Radiation oncology (London, England) 20110101

• Targeting HDACs: a promising therapy for Alzheimer's disease.

  Oxidative medicine and cellular longevity 20110101

• Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia.

  OncoTargets and therapy 20110101

• Generation of reactive oxygen species during apoptosis induced by DNA-damaging agents and/or histone deacetylase inhibitors.

  Oxidative medicine and cellular longevity 20110101

• Promoting illiteracy in epigenetics: an emerging therapeutic strategy.

  Current chemical genomics 20110101

• GSTP1 DNA methylation and expression status is indicative of 5-aza-2'-deoxycytidine efficacy in human prostate cancer cells.

  PloS one 20110101

• Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells.

  Retrovirology 20110101

• Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study.

  BMC cancer 20110101

• A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.

  PloS one 20110101

• Potential non-oncological applications of histone deacetylase inhibitors.

  American journal of translational research 20110101

• The microenvironment in breast cancer progression: biology and implications for treatment.

  Breast cancer research : BCR 20110101

• Epigenetics in breast cancer: what's new?

  Breast cancer research : BCR 20110101

• Secretome Analysis of Skeletal Myogenesis Using SILAC and Shotgun Proteomics.

  International journal of proteomics 20110101

• A Systematic Review and Meta-Analysis of Front-line Anthracycline-Based Chemotherapy Regimens for Peripheral T-Cell Lymphoma.

  ISRN hematology 20110101

• Metastatic bladder cancer: a review of current management.

  ISRN urology 20110101

• Concurrent HDAC and mTORC1 inhibition attenuate androgen receptor and hypoxia signaling associated with alterations in microRNA expression.

  PloS one 20110101

• New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer.

  Prostate cancer 20110101

• SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease.

  PloS one 20110101

• Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy.

  Journal of translational medicine 20110101

• Epigenetics in prostate cancer.

  Prostate cancer 20110101

• Molecular mechanisms of bortezomib resistant adenocarcinoma cells.

  PloS one 20110101

• Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.

  Clinical epigenetics 20110101

• Romidepsin in the treatment of cutaneous T-cell lymphoma.

  Journal of blood medicine 20110101

• An update on the management of peripheral T-cell lymphoma and emerging treatment options.

  Journal of blood medicine 20110101

• Autophagy: friend or foe in breast cancer development, progression, and treatment.

  International journal of breast cancer 20110101

• The role of aryl hydrocarbon receptor and crosstalk with estrogen receptor in response of breast cancer cells to the novel antitumor agents benzothiazoles and aminoflavone.

  International journal of breast cancer 20110101

• In silico modification of suberoylanilide hydroxamic acid (SAHA) as potential inhibitor for class II histone deacetylase (HDAC).

  BMC bioinformatics 20110101

• Suffocating cancer: hypoxia-associated epimutations as targets for cancer therapy.

  Clinical epigenetics 20110101

• Cell death signaling and anticancer therapy.

  Frontiers in oncology 20110101

• Investigational approaches for mesothelioma.

  Frontiers in oncology 20110101

• Ocular manifestations and pathology of adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus type 1.

  Rare tumors 20101231

• Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells.

  Blood 20101223

• Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.

  Journal of medicinal chemistry 20101223

• Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor.

  Journal of medicinal chemistry 20101223

• Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase.

  Bioorganic & medicinal chemistry 20101215

• Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell.

  Investigational new drugs 20101201

• Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines.

  The pharmacogenomics journal 20101201

• Identification of genes related to a synergistic effect of taxane and suberoylanilide hydroxamic acid combination treatment in gastric cancer cells.

  Journal of cancer research and clinical oncology 20101201

• Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancer.

  Annals of surgical oncology 20101201

• Autophagy and tumorigenesis.

  Seminars in immunopathology 20101201

• A novel xenograft model of cutaneous T-cell lymphoma.

  Experimental dermatology 20101201

• Inhibition of class IIb histone deacetylase significantly improves cloning efficiency in mice.

  Biology of reproduction 20101201

• Suberoylanilide hydroxamic acid partly reverses resistance to paclitaxel in human ovarian cancer cell lines.

  Gynecologic oncology 20101201

• Inhibitors selective for HDAC6 in enzymes and cells.

  Bioorganic & medicinal chemistry letters 20101201

• Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans.

  The EMBO journal 20101201

• The DAC system and associations with multiple myeloma.

  Investigational new drugs 20101201

• Deactylase inhibition in myeloproliferative neoplasms.

  Investigational new drugs 20101201

• Histone deacetylase inhibitors in Hodgkin lymphoma.

  Investigational new drugs 20101201

• Targeting histone deacetyalses in the treatment of B- and T-cell malignancies.

  Investigational new drugs 20101201

• The DAC system and associations with acute leukemias and myelodysplastic syndromes.

  Investigational new drugs 20101201

• The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss.

  Molecular cancer therapeutics 20101201

• Combination of vorinostat and flavopiridol is selectively cytotoxic to multidrug-resistant neuroblastoma cell lines with mutant TP53.

  Molecular cancer therapeutics 20101201

• Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect.

  Investigational new drugs 20101201

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20101201

• Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells.

  Bioorganic & medicinal chemistry letters 20101115

• Design and synthesis of novel pyrimidine hydroxamic acid inhibitors of histone deacetylases.

  Bioorganic & medicinal chemistry letters 20101115

• Poikilodermatous mycosis fungoides.

  Dermatology online journal 20101115

• Schwann cell autophagy induced by SAHA, 17-AAG, or clonazepam can reduce bortezomib-induced peripheral neuropathy.

  British journal of cancer 20101109

• Impact of histone deacetylase inhibitors SAHA and MS-275 on DNA repair pathways in human mesenchymal stem cells.

  Journal of cellular physiology 20101101

• Inhibition of radiation-induced DNA repair and prosurvival pathways contributes to vorinostat-mediated radiosensitization of pancreatic cancer cells.

  Pancreas 20101101

• Efficacy of MK-0457 and in combination with vorinostat against Philadelphia chromosome positive acute lymphoblastic leukemia cells.

  Annals of hematology 20101101

• HDAC inhibitors with different gene regulation activities depend on the mitochondrial pathway for the sensitization of leukemic T cells to TRAIL-induced apoptosis.

  Cancer letters 20101101

• In vitro and in vivo histone deacetylase inhibitor therapy with vorinostat and paclitaxel in ovarian cancer models: does timing matter?

  Gynecologic oncology 20101101

• The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances taxol-induced cell death in breast cancer.

  Cancer chemotherapy and pharmacology 20101101

• A histone deacetylase-dependent screen in yeast.

  Bioorganic & medicinal chemistry 20101101

• Induction of a less aggressive phenotype in human colon carcinoma HCT116 cells by chronic exposure to HDAC inhibitor SAHA.

  Oncology reports 20101101

• Synergistic killing effect between vorinostat and target of CD146 in malignant cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20101101

• Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma.

  Autophagy 20101101

• Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line.

  Experimental biology and medicine (Maywood, N.J.) 20101101

• Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.

  British journal of cancer 20101101

• Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types.

  British journal of cancer 20101026

• Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition.

  Blood 20101021

• Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanate.

  Blood 20101014

• Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation.

  Oncogene 20101014

• Phase I study of vorinostat in patients with advanced solid tumors and hepatic dysfunction: a National Cancer Institute Organ Dysfunction Working Group study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20101010

• Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation.

  Journal of cellular and molecular medicine 20101001

• Histone deacetylase inhibitors synergistically potentiate death receptor 4-mediated apoptotic cell death of human T-cell acute lymphoblastic leukemia cells.

  Apoptosis : an international journal on programmed cell death 20101001

• Protection of dopaminergic cells from MPP+-mediated toxicity by histone deacetylase inhibition.

  Brain research 20101001

• Regulation of apoptosis-associated genes by histone deacetylase inhibitors: implications in cancer therapy.

  Anti-cancer drugs 20101001

• The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.

  British journal of haematology 20101001

• Multigene expression-based predictors for sensitivity to Vorinostat and Velcade in non-small cell lung cancer.

  Molecular cancer therapeutics 20101001

• The combination of a histone deacetylase inhibitor with the BH3-mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy.

  Autophagy 20101001

• A pharmacogenetic study of vorinostat glucuronidation.

  Pharmacogenetics and genomics 20101001

• Solubilization of vorinostat by cyclodextrins.

  Journal of clinical pharmacy and therapeutics 20101001

• Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes.

  Aging 20101001

• HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2.

  Aging 20101001

• Histone deacetylase inhibitors prevent activation of tumour-reactive NK cells and T cells but do not interfere with their cytolytic effector functions.

  Cancer letters 20100928

• Vorinostat enhances the cytotoxic effects of the topoisomerase I inhibitor SN38 in glioblastoma cell lines.

  Journal of neuro-oncology 20100901

• Identification of type-specific anticancer histone deacetylase inhibitors: road to success.

  Cancer chemotherapy and pharmacology 20100901

• Actions of the anti-cancer drug suberoylanilide hydroxamic acid (SAHA) on human breast cancer cytoarchitecture in silicon microstructures.

  Biomaterials 20100901

• Treatment with histone deacetylase inhibitor attenuates MAP kinase mediated liver injury in a lethal model of septic shock.

  The Journal of surgical research 20100901

• Combination of suberoylanilide hydroxamic acid and ritonavir is effective against renal cancer cells.

  Urology 20100901

• Design and synthesis of novel isoxazole-based HDAC inhibitors.

  European journal of medicinal chemistry 20100901

• Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition.

  International journal of radiation oncology, biology, physics 20100901

• Investigational histone deacetylase inhibitors for non-Hodgkin lymphomas.

  Expert opinion on investigational drugs 20100901

• Histone deacetylase inhibitors in lymphoma.

  Current opinion in oncology 20100901

• Drug-induced regulation of target expression.

  PLoS computational biology 20100901

• [Development of HDAC inhibitors].

  Gan to kagaku ryoho. Cancer & chemotherapy 20100901

• Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton.

  Journal of medicinal chemistry 20100826

• Histone deacetylase inhibition as a mechanism for the therapeutic effect of statins (3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors) in follicular lymphoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100820

• Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.

  Proceedings of the National Academy of Sciences of the United States of America 20100817

• A novel Ca2+/calmodulin antagonist HBC inhibits angiogenesis and down-regulates hypoxia-inducible factor.

  The Journal of biological chemistry 20100813

• A structure-activity relationship study of the antimalarial and antileishmanial activities of nonpeptide macrocyclic histone deacetylase inhibitors.

  ChemMedChem 20100802

• Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant.

  The Journal of clinical investigation 20100802

• The histone deacetylase inhibitor vorinostat induces calreticulin exposure in childhood brain tumour cells in vitro.

  Cancer chemotherapy and pharmacology 20100801

• Histone deacetylase inhibitors MS-275 and SAHA induced growth arrest and suppressed lipopolysaccharide-stimulated NF-kappaB p65 nuclear accumulation in human rheumatoid arthritis synovial fibroblastic E11 cells.

  Rheumatology (Oxford, England) 20100801

• The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100801

• Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells.

  Autophagy 20100801

• Surviving lethal septic shock without fluid resuscitation in a rodent model.

  Surgery 20100801

• Anticancer effects of the MHY218 novel hydroxamic acid-derived histone deacetylase inhibitor in human ovarian cancer cells.

  International journal of oncology 20100801

• Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100801

• Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.

  Cancer research 20100801

• Validation of a novel statistical model for assessing the synergy of combined-agent cancer chemoprevention.

  Cancer prevention research (Philadelphia, Pa.) 20100801

• Serine proteases in histone deacetylase inhibitor-induced apoptosis.

  Molecular cancer therapeutics 20100801

• Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells.

  Molecular cancer therapeutics 20100801

• An experimental study of rabbit conjunctival epithelial toxicity using co-treatment with mitomycin-C and a histone deacetylase inhibitor.

  Archives of pharmacal research 20100801

• A phase I, pharmacokinetic, and pharmacodynamic study of two schedules of vorinostat in combination with 5-fluorouracil and leucovorin in patients with refractory solid tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100715

• The functional significance of microRNA-145 in prostate cancer.

  British journal of cancer 20100713

• The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis, down-regulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells.

  Haematologica 20100701

• The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice.

  Cardiovascular research 20100701

• A phase I study of vorinostat in combination with idarubicin in relapsed or refractory leukaemia.

  British journal of haematology 20100701

• Targeted treatment and new agents in peripheral T-cell lymphoma.

  International journal of hematology 20100701

• Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity.

  Bioorganic & medicinal chemistry letters 20100701

• A phase I study of the safety and pharmacokinetics of the histone deacetylase inhibitor belinostat administered in combination with carboplatin and/or paclitaxel in patients with solid tumours.

  British journal of cancer 20100629

• Suberoylanilide hydroxamic acid limits migration and invasion of glioma cells in two and three dimensional culture.

  Cancer letters 20100628

• Probing the probes: fitness factors for small molecule tools.

  Chemistry & biology 20100625

• Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.

  Journal of medicinal chemistry 20100624

• Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function .

  Biochemistry 20100622

• New aryldithiolethione derivatives as potent histone deacetylase inhibitors.

  Bioorganic & medicinal chemistry 20100615

• The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo.

  Blood 20100603

• Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.

  Journal of leukocyte biology 20100601

• Anti-melanoma effects of vorinostat in combination with polyphenolic antioxidant (-)-epigallocatechin-3-gallate (EGCG).

  Pharmaceutical research 20100601

• Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21(waf1/cip1) expression.

  Cancer science 20100601

• Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.

  Bioorganic & medicinal chemistry letters 20100601

• Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.

  Bioorganic & medicinal chemistry 20100601

• Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage.

  Cancer research 20100601

• Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids.

  Cancer 20100601

• Turning off the switch in medulloblastoma: the inhibitory acetylation of an oncogene.

  Cell cycle (Georgetown, Tex.) 20100601

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20100601

• Exciting new targets in lung cancer therapy: ALK, IGF-1R, HDAC, and Hh.

  Current treatment options in oncology 20100601

• Targeting histone deacetylases: development of vorinostat for the treatment of cancer.

  Epigenomics 20100601

• AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.

  Blood 20100527

• Suberoylanilide hydroxamic acid induces viral lytic cycle in Epstein-Barr virus-positive epithelial malignancies and mediates enhanced cell death.

  International journal of cancer 20100515

• Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.

  Bioorganic & medicinal chemistry letters 20100515

• Synthesis and anticancer evaluation of alpha-lipoic acid derivatives.

  Bioorganic & medicinal chemistry letters 20100515

• Histone deacetylase inhibitors: Are they here to stay?

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100515

• Vorinostat: A novel therapy for the treatment of cutaneous T-cell lymphoma.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100515

• Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease.

  Neuroscience letters 20100514

• Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study.

  The Lancet. Oncology 20100501

• Combined proteasome and histone deacetylase inhibition attenuates epithelial-mesenchymal transition through E-cadherin in esophageal cancer cells.

  The Journal of thoracic and cardiovascular surgery 20100501

• [Vorinostat in the treatment of cutaneous T-cell lymphomas. Treatment with histone deacetylases inhibitors].

  Pharmazie in unserer Zeit 20100501

• SAHA and curcumin combinations co-enhance histone acetylation in human cancer cells but operate antagonistically in exerting cytotoxic effects.

  Journal of Asian natural products research 20100501

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20100501

• Diagnosis and management of mycosis fungoides.

  Oncology (Williston Park, N.Y.) 20100501

• [Three different drug interaction mathematical models used to evaluate the cytotoxicity of SAHA and arsenic trioxide in combination].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100501

• Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity.

  Journal of medicinal chemistry 20100422

• SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy.

  Human molecular genetics 20100415

• Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100415

• Synthesis of N-hydroxycinnamides capped with a naturally occurring moiety as inhibitors of histone deacetylase.

  ChemMedChem 20100406

• Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells.

  Breast cancer research and treatment 20100401

• Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex.

  International journal of cancer 20100401

• A phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy.

  Cancer chemotherapy and pharmacology 20100401

• Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma.

  Haematologica 20100401

• Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats.

  British journal of pharmacology 20100401

• Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics.

  International journal of oncology 20100401

• The role of histone deacetylase inhibitors in the treatment of patients with cutaneous T-cell lymphoma.

  Clinical lymphoma, myeloma & leukemia 20100401

• Vorinostat plus bortezomib for the treatment of relapsed/refractory multiple myeloma: a case series illustrating utility in clinical practice.

  Clinical lymphoma, myeloma & leukemia 20100401

• Emerging role of epigenetic therapies in cutaneous T-cell  lymphomas.

  Expert review of hematology 20100401

• The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice.

  Blood 20100325

• SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors.

  Bioorganic & medicinal chemistry letters 20100315

• Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.

  Journal of medicinal chemistry 20100311

• Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring.

  Journal of medicinal chemistry 20100311

• Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation.

  Molecular therapy : the journal of the American Society of Gene Therapy 20100301

• Vorinostat enhances the antimyeloma effects of melphalan and bortezomib.

  European journal of haematology 20100301

• Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100301

• Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100301

• The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition.

  Cellular and molecular life sciences : CMLS 20100301

• Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells.

  Proteomics 20100301

• Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy.

  Leukemia 20100301

• Chemical phylogenetics of histone deacetylases.

  Nature chemical biology 20100301

• Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors.

  Bioorganic & medicinal chemistry 20100301

• SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer.

  Molecular cancer therapeutics 20100301

• Current and emerging treatment strategies for cutaneous T-cell lymphoma.

  Drugs 20100212

• Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.

  Journal of medicinal chemistry 20100211

• Vorinostat increases carboplatin and paclitaxel activity in non-small-cell lung cancer cells.

  International journal of cancer 20100201

• Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells.

  American journal of physiology. Renal physiology 20100201

• Induction of thyroid gene expression and radioiodine uptake in thyroid cancer cells by targeting major signaling pathways.

  The Journal of clinical endocrinology and metabolism 20100201

• Histone deacetylase inhibitors in malignant pleural mesothelioma: preclinical rationale and clinical trials.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20100201

• Suberoylanilide hydroxyamic acid modification of chromatin architecture affects DNA break formation and repair.

  International journal of radiation oncology, biology, physics 20100201

• HDAC inhibitors in cancer care.

  Oncology (Williston Park, N.Y.) 20100201

• Will DNA methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors.

  Epigenomics 20100201

• Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex.

  Chemistry & biology 20100129

• Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.

  Journal of medicinal chemistry 20100128

• Fluoroalkene modification of mercaptoacetamide-based histone deacetylase inhibitors.

  Bioorganic & medicinal chemistry 20100115

• Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation.

  Oncogene 20100107

• Potential efficacy of the oral histone deacetylase inhibitor vorinostat in a phase I trial in follicular and mantle cell lymphoma.

  Cancer science 20100101

• Suberoylanilide hydroxamic acid (SAHA) potentiates paclitaxel-induced apoptosis in ovarian cancer cell lines.

  Gynecologic oncology 20100101

• Nonclinical safety assessment of the histone deacetylase inhibitor vorinostat.

  International journal of toxicology 20100101

• Suberoylanilide hydroxamic acid (SAHA) at subtoxic concentrations increases the adhesivity of human leukemic cells to fibronectin.

  Journal of cellular biochemistry 20100101

• Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.

  Bioorganic & medicinal chemistry 20100101

• Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100101

• HDAC inhibition radiosensitizes human normal tissue cells and reduces DNA Double-Strand Break repair capacity.

  Oncology reports 20100101

• Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

  Nature chemical biology 20100101

• Vorinostat enhances the activity of temsirolimus in renal cell carcinoma through suppression of survivin levels.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100101

• Histone deacetylase inhibitor therapy in epithelial ovarian cancer.

  Journal of oncology 20100101

• The saving switch.

  Nature medicine 20100101

• Activation of the unfolded protein response contributes toward the antitumor activity of vorinostat.

  Neoplasia (New York, N.Y.) 20100101

• Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.

  PloS one 20100101

• Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents.

  Journal of hematology & oncology 20100101

• EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis.

  Molecular cancer 20100101

• PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells.

  International journal of cell biology 20100101

• Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.

  International journal of cell biology 20100101

• Preclinical studies of chemotherapy using histone deacetylase inhibitors in endometrial cancer.

  Obstetrics and gynecology international 20100101

• BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer.

  Journal of oncology 20100101

• Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection.

  PloS one 20100101

• Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo.

  Molecular cancer 20100101

• Response to hydralazine-valproate in a patient with mycosis fungoides.

  Case reports in medicine 20100101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20100101

• Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma.

  Journal of oncology 20100101

• Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights.

  Journal of hematology & oncology 20100101

• Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.

  BMC molecular biology 20100101

• Updates in non-small cell lung cancer--insights from the 2009 45th annual meeting of the American Society of Clinical Oncology.

  Journal of hematology & oncology 20100101

• Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides.

  Marine drugs 20100101

• Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.

  PloS one 20100101

• The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo.

  PloS one 20100101

• Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies.

  Journal of translational medicine 20100101

• Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner.

  PloS one 20100101

• Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor.

  PloS one 20100101

• An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes.

  OncoTargets and therapy 20100101

• Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat.

  PloS one 20100101

• Molecular and therapeutic potential and toxicity of valproic acid.

  Journal of biomedicine & biotechnology 20100101

• Activating Transcription Factor 3 regulates in part the enhanced tumour cell cytotoxicity of the histone deacetylase inhibitor M344 and cisplatin in combination.

  Cancer cell international 20100101

• Suberoylanilide hydroxamic acid induces apoptosis and sub-G1 arrest of 320 HSR colon cancer cells.

  Journal of biomedical science 20100101

• Epigenetic approaches in the treatment of myelodysplastic syndromes: clinical utility of azacitidine.

  OncoTargets and therapy 20100101

• A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer.

  PloS one 20100101

• Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor.

  Molecular cancer 20100101

• Oral systemic therapy: Not all 'win-win'.

  Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology 20100101

• Safety and efficacy of azacitidine in myelodysplastic syndromes.

  Drug design, development and therapy 20100101

• Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery.

  International journal of cell biology 20100101

• Targeted therapy in lymphoma.

  Journal of hematology & oncology 20100101

• Proteasome inhibition and its therapeutic potential in multiple myeloma.

  Biologics : targets & therapy 20100101

• Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

  PloS one 20100101

• Proteomic profile of differentially expressed plasma proteins from dystrophic mice and following suberoylanilide hydroxamic acid treatment.

  Proteomics. Clinical applications 20100101

• Temsirolimus in the treatment of relapsed and/or refractory mantle cell lymphoma.

  Cancer management and research 20100101

• An update in management of noncutaneous T-cell lymphomas.

  Advances in hematology 20100101

• CoFactor: Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy.

  Journal of oncology 20100101

• Peripheral T-cell lymphoma: review and updates of current management strategies.

  Advances in hematology 20100101

• Relapsed multiple myeloma.

  Hematology. American Society of Hematology. Education Program 20100101

• Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors.

  PloS one 20100101

• New treatments for myelodysplastic syndromes.

  Mediterranean journal of hematology and infectious diseases 20100101

• Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA.

  Molecular medicine reports 20100101

• A putrescine-anthracene conjugate: a paradigm for selective drug delivery.

  The Biochemical journal 20091215

• Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): trial results and interleukin-6 analysis: a study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago Phase 2 Consortium.

  Cancer 20091201

• HTS and hit finding in academia--from chemical genomics to drug discovery.

  Drug discovery today 20091201

• Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide.

  Bioorganic & medicinal chemistry letters 20091201

• MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells.

  International journal of oncology 20091201

• Molecular targets in malignant pleural mesothelioma treatment.

  Current drug targets 20091201

• Emerging treatment combinations: integrating therapy into clinical practice.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091201

• New patented histone deacetylase inhibitors.

  Expert opinion on therapeutic patents 20091201

• Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T-cell lymphoma.

  Clinical lymphoma & myeloma 20091201

• Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20091201

• New treatment strategy enhances outcome for lung cancer.

  Cancer biology & therapy 20091201

• A single supratherapeutic dose of vorinostat does not prolong the QTc interval in patients with advanced cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20091115

• Hydroxamates: relationships between structure and plasma stability.

  Journal of medicinal chemistry 20091112

• Histone deacetylase inhibitors in cancer therapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091110

• Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells.

  Cancer chemotherapy and pharmacology 20091101

• Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents.

  Shock (Augusta, Ga.) 20091101

• Response of an adult patient with pineoblastoma to vorinostat and retinoic acid.

  Journal of neuro-oncology 20091101

• Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni.

  Molecular and biochemical parasitology 20091101

• Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetylase inhibitors.

  European journal of medicinal chemistry 20091101

• Pathway targets to explore in the treatment of small cell and large cell lung cancers.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20091101

• Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications.

  European journal of cancer (Oxford, England : 1990) 20091101

• Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis.

  Molecular cancer therapeutics 20091101

• Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach.

  Molecular cancer therapeutics 20091101

• Leukonychia related to vorinostat.

  Archives of dermatology 20091101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20091101

• Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene.

  Journal of molecular biology 20091023

• Suberoylanilide hydroxamic acid promotes cardiomyocyte differentiation of rat mesenchymal stem cells.

  Experimental cell research 20091015

• Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor.

  Journal of medicinal chemistry 20091008

• Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker.

  British journal of cancer 20091006

• Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells.

  The Journal of pharmacology and experimental therapeutics 20091001

• Vorinostat interferes with Wnt and NF-kappaB pathways in the M-07e cell line.

  Leukemia 20091001

• A novel histone deacetylase inhibitor, CG0006, induces cell death through both extrinsic and intrinsic apoptotic pathways.

  Anti-cancer drugs 20091001

• Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.

  Bioorganic & medicinal chemistry letters 20091001

• Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20091001

• A phase 2 study of vorinostat in acute myeloid leukemia.

  Haematologica 20091001

• Antidepressant actions of histone deacetylase inhibitors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090916

• SAHA treatment overcomes the anti-apoptotic effects of Bcl-2 and is associated with the formation of mature PML nuclear bodies in human leukemic U937 cells.

  Chemico-biological interactions 20090914

• Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.

  Oncogene 20090903

• Inhibition of histone deacetylase suppresses EGF signaling pathways by destabilizing EGFR mRNA in ER-negative human breast cancer cells.

  Breast cancer research and treatment 20090901

• Antitumor activity of suberoylanilide hydroxamic acid against human oral squamous cell carcinoma cell lines in vitro and in vivo.

  Oral oncology 20090901

• Molecular sequelae of histone deacetylase inhibition in human retinoblastoma cell lines: clinical implications.

  Investigative ophthalmology & visual science 20090901

• Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program.

  Pediatric blood & cancer 20090901

• Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger.

  Journal of industrial microbiology & biotechnology 20090901

• KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57(Kip2).

  Apoptosis : an international journal on programmed cell death 20090901

• Cell cycle and apoptotic effects of SAHA are regulated by the cellular microenvironment in HCT116 multicellular tumour spheroids.

  European journal of cancer (Oxford, England : 1990) 20090901

• Phase I and pharmacokinetic study of vorinostat (suberoylanilide hydroxamic acid) in Japanese patients with solid tumors.

  Cancer science 20090901

• MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells.

  International journal of oncology 20090901

• The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation.

  European journal of cancer (Oxford, England : 1990) 20090901

• Short communication: activation of latent HIV type 1 gene expression by suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor approved for use to treat cutaneous T cell lymphoma.

  AIDS research and human retroviruses 20090901

• Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.

  Cancer research 20090901

• Suberoylanilide hydroxamic acid sensitizes human oral cancer cells to TRAIL-induced apoptosis through increase DR5 expression.

  Molecular cancer therapeutics 20090901

• Vorinostat for the treatment of bullous pemphigoid in the setting of advanced, refractory cutaneous T-cell lymphoma.

  Archives of dermatology 20090901

• The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation.

  Free radical biology & medicine 20090815

• Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.

  Cancer research 20090815

• Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090815

• Lysine acetylation targets protein complexes and co-regulates major cellular functions.

  Science (New York, N.Y.) 20090814

• Recent advances in the development of polyamine analogues as antitumor agents.

  Journal of medicinal chemistry 20090813

• MeCP2 function in the basolateral amygdala in Rett syndrome.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090812

• Development of vorinostat: current applications and future perspectives for cancer therapy.

  Cancer letters 20090808

• HDAC inhibitors: magic bullets, dirty drugs or just another targeted therapy.

  Cancer letters 20090808

• Histone deacetylase inhibitors as anti-neoplastic agents.

  Cancer letters 20090808

• Enhancing the apoptotic and therapeutic effects of HDAC inhibitors.

  Cancer letters 20090808

• The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis.

  Leukemia 20090801

• Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.

  Molecular pharmacology 20090801

• BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.

  Molecular pharmacology 20090801

• HDAC inhibitor-based therapies and haematological malignancy.

  Annals of oncology : official journal of the European Society for Medical Oncology 20090801

• Histone modifier, the gatekeeper of good memory.

  Cell research 20090801

• In vitro evaluation of histone deacetylase inhibitors as combination agents for colorectal cancer.

  Anticancer research 20090801

• Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells.

  International journal of cancer 20090715

• Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.

  Bioorganic & medicinal chemistry 20090715

• Clinical efficacy of vorinostat in a patient with essential thrombocytosis and subsequent myelofibrosis.

  Annals of hematology 20090701

• Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis?

  The European respiratory journal 20090701

• Novel therapies for peripheral T-cell non-Hodgkin's lymphomas.

  Current opinion in hematology 20090701

• Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer.

  Cancer biology & therapy 20090701

• Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells.

  Cancer biology & therapy 20090701

• Epigenetic modulation and attacking the hedgehog pathway: potentially synergistic therapeutic targets for pancreatic cancer.

  Cancer biology & therapy 20090701

• Histone deacetylase inhibitors: Potential in cancer therapy.

  Journal of cellular biochemistry 20090701

• Suberoylanilide hydroxamic acid (SAHA) changes microRNA expression profiles in A549 human non-small cell lung cancer cells.

  International journal of molecular medicine 20090701

• A novel regimen of vorinostat with interferon gamma for refractory Sézary syndrome.

  Journal of the American Academy of Dermatology 20090701

• Clinical roundtable monograph. Combination therapies for MDS.

  Clinical advances in hematology & oncology : H&O 20090701

• Epigenetic modifiers: basic understanding and clinical development.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090615

• Clinical studies of histone deacetylase inhibitors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090615

• Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.

  Journal of medicinal chemistry 20090611

• Pharmacokinetics and tissue distribution of Kendine 91, a novel histone deacetylase inhibitor, in mice.

  Cancer chemotherapy and pharmacology 20090601

• An apicomplexan ankyrin-repeat histone deacetylase with relatives in photosynthetic eukaryotes.

  International journal for parasitology 20090601

• Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in cutaneous T cell lymphoma.

  European journal of haematology 20090601

• Suberoylanilide hydroxamic acid (SAHA) induces growth arrest and apoptosis in pituitary adenoma cells.

  Endocrine 20090601

• Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities.

  Anti-cancer drugs 20090601

• Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.

  Bioorganic & medicinal chemistry letters 20090601

• Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.

  Bioorganic & medicinal chemistry letters 20090601

• Radiosensitization by SAHA in experimental colorectal carcinoma models-in vivo effects and relevance of histone acetylation status.

  International journal of radiation oncology, biology, physics 20090601

• Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090601

• American Association for Cancer Research 100th Annual Meeting.

  The Lancet. Oncology 20090601

• Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts.

  Molecular cancer therapeutics 20090601

• Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice.

  Molecular cancer therapeutics 20090601

• Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.

  Bioorganic & medicinal chemistry letters 20090515

• Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases.

  Journal of medicinal chemistry 20090514

• Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors.

  Journal of medicinal chemistry 20090514

• HDAC2 negatively regulates memory formation and synaptic plasticity.

  Nature 20090507

• Histone deacetylase inhibitors promote apoptosis and senescence in human mesenchymal stem cells.

  Stem cells and development 20090501

• Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.

  European journal of medicinal chemistry 20090501

• Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain.

  Molecular pharmacology 20090501

• Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed.

  Cancer biology & therapy 20090501

• Efficient continuous flow synthesis of hydroxamic acids and suberoylanilide hydroxamic acid preparation.

  The Journal of organic chemistry 20090501

• A phase I, pharmacokinetic and pharmacodynamic study on vorinostat in combination with 5-fluorouracil, leucovorin, and oxaliplatin in patients with refractory colorectal cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090501

• Targeted therapies for renal cell carcinoma: more gains from using them again.

  Current oncology (Toronto, Ont.) 20090501

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20090501

• Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells.

  Blood 20090430

• Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77-based mechanism.

  Blood 20090423

• Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.

  Journal of medicinal chemistry 20090423

• Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.

  Journal of medicinal chemistry 20090423

• Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090420

• Valproate, in combination with pemetrexed and cisplatin, provides additional efficacy to the treatment of malignant mesothelioma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090415

• Zn(II)-dependent histone deacetylase inhibitors: suberoylanilide hydroxamic acid and trichostatin A.

  The international journal of biochemistry & cell biology 20090401

• ErbB-3 expression is associated with E-cadherin and their coexpression restores response to gefitinib in non-small-cell lung cancer (NSCLC).

  Annals of oncology : official journal of the European Society for Medical Oncology 20090401

• Characterization of UGTs active against SAHA and association between SAHA glucuronidation activity phenotype with UGT genotype.

  Cancer research 20090401

• Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain.

  Nuclear medicine and biology 20090401

• Variations in c-Myc and p21WAF1 expression protect normal peripheral blood lymphocytes against BimEL-mediated cell death.

  Cell biochemistry and function 20090401

• Melding a New 3-Dimensional Agarose Colony Assay with the E(max) Model to Determine the Effects of Drug Combinations on Cancer Cells.

  Technology in cancer research & treatment 20090401

• MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090401

• Vorinostat (NSC# 701852) in patients with relapsed non-small cell lung cancer: a Wisconsin Oncology Network phase II study.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20090401

• A kernel for open source drug discovery in tropical diseases.

  PLoS neglected tropical diseases 20090401

• Regulation of adipocyte differentiation by histone deacetylase inhibitors.

  Archives of pharmacal research 20090401

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20090401

• HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling.

  The Journal of biological chemistry 20090320

• Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity.

  Oncogene 20090319

• Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives.

  Bioorganic & medicinal chemistry 20090315

• Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells.

  The Journal of biological chemistry 20090313

• Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells.

  Arteriosclerosis, thrombosis, and vascular biology 20090301

• Elevated NCOR1 disrupts a network of dietary-sensing nuclear receptors in bladder cancer cells.

  Carcinogenesis 20090301

• Preclinical studies of vorinostat (suberoylanilide hydroxamic acid) combined with cytosine arabinoside and etoposide for treatment of acute leukemias.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090301

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20090301

• Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors.

  Blood 20090226

• Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells.

  International journal of cancer 20090215

• Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models.

  Molecular cancer therapeutics 20090201

• Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid.

  AIDS research and human retroviruses 20090201

• The anticancer effect of histone deacetylase inhibitors and combination with the cytotoxic agents in lung cancer cells: biological analyses for future clinical application.

  Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20090201

• High-throughput screening compatible cell-based assay for interrogating activated notch signaling.

  Assay and drug development technologies 20090201

• Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition.

  Human molecular genetics 20090115

• Sulfamides as novel histone deacetylase inhibitors.

  Bioorganic & medicinal chemistry letters 20090115

• Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090115

• A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma.

  British journal of cancer 20090113

• Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinoma.

  The Journal of clinical endocrinology and metabolism 20090101

• Structure-activity relationship studies of novel oxygen-incorporated SAHA analogues.

  Archives of pharmacal research 20090101

• Targeting histone deacetylases in neuroblastoma.

  Current pharmaceutical design 20090101

• Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy.

  Molecular cancer 20090101

• Toxicity of targeted therapy in non-small-cell lung cancer management.

  Clinical lung cancer 20090101

• Assays for histone deacetylases.

  Current topics in medicinal chemistry 20090101

• Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and beta-hemoglobinopathies.

  Current topics in medicinal chemistry 20090101

• Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitors.

  Cellular immunology 20090101

• New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer.

  Journal of hematology & oncology 20090101

• 'Shock and kill' effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence.

  Retrovirology 20090101

• Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

  PloS one 20090101

• Vorinostat in solid and hematologic malignancies.

  Journal of hematology & oncology 20090101

• Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth.

  PloS one 20090101

• Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions.

  PloS one 20090101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20090101

• Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival.

  Molecular cancer 20090101

• High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo.

  BMC cancer 20090101

• DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines.

  BMC medical genomics 20090101

• Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies.

  Retrovirology 20090101

• Managing myelodysplastic symptoms in elderly patients.

  Clinical interventions in aging 20090101

• Targeted therapy in the treatment of malignant gliomas.

  OncoTargets and therapy 20090101

• Lenalidomide in multiple myeloma: an evidence-based review of its role in therapy.

  Core evidence 20090101

• Effects of a selection of histone deacetylase inhibitors on mast cell activation and airway and colonic smooth muscle contraction.

  International immunopharmacology 20081220

• Histone deacetylase inhibitors through click chemistry.

  Journal of medicinal chemistry 20081211

• HDAC inhibition upregulates the expression of angiostatic ADAMTS1.

  FEBS letters 20081210

• Histone deacetylase inhibitors sensitize tumour cells for cytotoxic effects of natural killer cells.

  Cancer letters 20081208

• Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo.

  Journal of leukocyte biology 20081201

• Drug Insight: histone deacetylase inhibitor-based therapies for cutaneous T-cell lymphomas.

  Nature clinical practice. Oncology 20081201

• SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway.

  The Journal of pathology 20081201

• Molecular biology and targeted therapy of cutaneous T-cell lymphomas.

  Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20081201

• Proteomic analysis of cervical cancer cells treated with suberonylanilide hydroxamic acid.

  Journal of biosciences 20081201

• Denileukin diftitox for the treatment of cutaneous T-cell lymphoma.

  Biologics : targets & therapy 20081201

• Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.

  Journal of medicinal chemistry 20081127

• Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells.

  Breast cancer research and treatment 20081101

• Sensitization of RPE cells by alphaB-crystallin siRNA to SAHA-induced stage 1 apoptosis through abolishing the association of alphaB-crystallin with HDAC1 in SC35 speckles.

  Investigative ophthalmology & visual science 20081101

• A multiple-loop, double-cube microarray design applied to prostate cancer cell lines with variable sensitivity to histone deacetylase inhibitors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081101

• A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081101

• Comparative molecular dynamics simulations of histone deacetylase-like protein: binding modes and free energy analysis to hydroxamic acid inhibitors.

  Proteins 20081001

• The potential role of histone deacetylase inhibitors in the treatment of non-small-cell lung cancer.

  Critical reviews in oncology/hematology 20081001

• Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer.

  Investigational new drugs 20081001

• Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.

  Blood 20081001

• Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells.

  Blood 20081001

• HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2.

  Biochimica et biophysica acta 20081001

• Regulation of autophagy by ceramide-CD95-PERK signaling.

  Autophagy 20081001

• Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment.

  Cancer biology & therapy 20081001

• Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.

  Cancer biology & therapy 20081001

• Treatment of cutaneous T-cell lymphoma: focus on vorinostat.

  Journal of the American Academy of Dermatology 20081001

• Future directions in myelodysplastic syndrome: newer agents and the role of combination approaches.

  Cancer control : journal of the Moffitt Cancer Center 20081001

• Histone deacetylase inhibitors: apoptotic effects and clinical implications (Review).

  International journal of oncology 20081001

• Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081001

• [Epigenetics in hematological disorders].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20081001

• Histone deacetylase inhibitors as novel anticancer therapeutics.

  Current oncology (Toronto, Ont.) 20081001

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20081001

• Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents.

  Bioorganic & medicinal chemistry letters 20080915

• Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

  British journal of cancer 20080902

• Synthesis of benzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities.

  ChemMedChem 20080901

• In vitro plasma stability, permeability and solubility of mercaptoacetamide histone deacetylase inhibitors.

  International journal of pharmaceutics 20080901

• Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma.

  Annals of surgical oncology 20080901

• Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma.

  Histopathology 20080901

• Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer.

  Cancer biology & therapy 20080901

• Recent advances in the treatment of malignant pleural mesothelioma.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20080901

• Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080901

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20080901

• Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.

  Journal of the American Chemical Society 20080820

• Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines.

  Blood 20080815

• Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.

  Journal of medicinal chemistry 20080814

• Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate.

  Blood 20080801

• The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells.

  International journal of oncology 20080801

• Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans.

  Surgery 20080801

• Differential responsiveness of human hepatoma cells versus normal hepatocytes to TRAIL in combination with either histone deacetylase inhibitors or conventional cytostatics.

  Cancer science 20080801

• Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type beta-catenin nuclear accumulation in lung tumorigenesis.

  Oncogene 20080724

• Experimental design and interaction analysis of combination studies of drugs with log-linear dose responses.

  Statistics in medicine 20080720

• Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles.

  Journal of medicinal chemistry 20080710

• Proteomic analysis identifies protein targets responsible for depsipeptide sensitivity in tumor cells.

  Journal of proteome research 20080701

• Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice.

  The Journal of clinical investigation 20080701

• Isoform-selective histone deacetylase inhibitors.

  Chemical Society reviews 20080701

• Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells.

  Oncology reports 20080701

• Evaluation of the effects of histone deacetylase inhibitors on cells from canine cancer cell lines.

  American journal of veterinary research 20080701

• Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model.

  Molecular cancer therapeutics 20080701

• Histone deacetylase inhibitors: mechanism of action and therapeutic use in cancer.

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20080701

• Targeted treatment and new agents in diffuse large B-cell lymphoma.

  Seminars in hematology 20080701

• A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.

  Journal of medicinal chemistry 20080626

• Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents.

  The Journal of pharmacology and experimental therapeutics 20080601

• Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias.

  Current medicinal chemistry 20080601

• Targeting autophagy: a novel anticancer strategy with therapeutic implications for imatinib resistance.

  Biologics : targets & therapy 20080601

• The use of diversity profiling to characterize chemical modulators of the histone deacetylases.

  Life sciences 20080523

• Structural origin of selectivity in class II-selective histone deacetylase inhibitors.

  Journal of medicinal chemistry 20080522

• Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma.

  Cancer research 20080515

• OSU-HDAC42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model.

  Cancer research 20080515

• Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080515

• Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.

  Gut 20080501

• A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study.

  Gynecologic oncology 20080501

• Phase II trial of oral vorinostat (suberoylanilide hydroxamic acid) in relapsed diffuse large-B-cell lymphoma.

  Annals of oncology : official journal of the European Society for Medical Oncology 20080501

• Histone deacetylase inhibitor SAHA induces ERalpha degradation in breast cancer MCF-7 cells by CHIP-mediated ubiquitin pathway and inhibits survival signaling.

  Biochemical pharmacology 20080501

• Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group.

  Bioorganic & medicinal chemistry 20080501

• Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases.

  Bioorganic & medicinal chemistry letters 20080501

• Monitoring the effect of belinostat in solid tumors by H4 acetylation.

  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20080501

• KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.

  Molecular cancer therapeutics 20080501

• Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin.

  Molecular cancer therapeutics 20080501

• Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor.

  Molecular cancer therapeutics 20080501

• Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate.

  Journal of the American Academy of Dermatology 20080501

• Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors.

  Journal of medicinal chemistry 20080424

• Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.

  Bioorganic & medicinal chemistry letters 20080415

• Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid.

  Cancer chemotherapy and pharmacology 20080401

• Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA).

  Journal of neuro-oncology 20080401

• Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma.

  Experimental hematology 20080401

• Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2.

  Cancer research 20080401

• Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts.

  Neoplasia (New York, N.Y.) 20080401

• MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo.

  Molecular cancer therapeutics 20080401

• HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen.

  Proceedings of the National Academy of Sciences of the United States of America 20080325

• Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.

  Bioorganic & medicinal chemistry 20080315

• Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.

  Bioorganic & medicinal chemistry letters 20080315

• Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.

  Journal of medicinal chemistry 20080313

• Vorinostat and bortezomib significantly inhibit WT1 gene expression in MO7-e and P39 cell lines.

  Leukemia 20080301

• Combined effects of sulindac and suberoylanilide hydroxamic acid on apoptosis induction in human lung cancer cells.

  Molecular pharmacology 20080301

• Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells.

  Haematologica 20080301

• Phase I trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma.

  Leukemia & lymphoma 20080301

• Co-treatment of suberoylanilide hydroxamic acid and mitomycin-C induces the apoptosis of rabbit tenon's capsule fibroblast and improves the outcome of glaucoma filtration surgery.

  Current eye research 20080301

• Histone deacetylase inhibitors in lymphoma and solid malignancies.

  Expert review of anticancer therapy 20080301

• Effects of histone deacetylase inhibitor SAHA on effector and FOXP3+regulatory T cells in rhesus macaques.

  Transplantation proceedings 20080301

• Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes.

  Journal of the American Chemical Society 20080220

• Simultaneous determination of decitabine and vorinostat (Suberoylanalide hydroxamic acid, SAHA) by liquid chromatography tandem mass spectrometry for clinical studies.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080215

• Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor kappaB.

  Leukemia research 20080201

• Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer.

  Investigational new drugs 20080201

• Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes.

  Blood 20080201

• Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma.

  European journal of haematology 20080201

• Assessment of female and male fertility in Sprague-Dawley rats administered vorinostat, a histone deacetylase inhibitor.

  Birth defects research. Part B, Developmental and reproductive toxicology 20080201

• Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors.

  The Biochemical journal 20080115

• Autophagy induced by suberoylanilide hydroxamic acid in Hela S3 cells involves inhibition of protein kinase B and up-regulation of Beclin 1.

  The international journal of biochemistry & cell biology 20080101

• Amino acid derivatives as histone deacetylase inhibitors.

  Bioorganic & medicinal chemistry letters 20080101

• Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects.

  International journal of oncology 20080101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20080101

• EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma.

  PloS one 20080101

• A simple and robust method for connecting small-molecule drugs using gene-expression signatures.

  BMC bioinformatics 20080101

• Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells.

  Molecular cancer 20080101

• Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways.

  Journal of hematology & oncology 20080101

• Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines.

  Anticancer research 20080101

• Prostate 25-hydroxyvitamin D-1alpha-hydroxylase is up-regulated by suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor.

  Anticancer research 20080101

• FDG-PET/CT for the evaluation of response to therapy of cutaneous T-cell lymphoma to vorinostat (suberoylanilide hydroxamic acid, SAHA) in a phase II trial.

  Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20080101

• Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells.

  Molecular cancer 20080101

• Gateways to clinical trials. July-August 2008.

  Methods and findings in experimental and clinical pharmacology 20080101

• Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?

  Arthritis research & therapy 20080101

• Ovarian cancer plasticity and epigenomics in the acquisition of a stem-like phenotype.

  Journal of ovarian research 20080101

• Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer.

  BMC cancer 20080101

• A Single Institution's Experience with Bevacizumab in Combination with Cytotoxic Chemotherapy in Progressive Malignant Glioma.

  Clinical medicine. Oncology 20080101

• Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.

  Journal of medicinal chemistry 20071227

• Mechanisms of resistance to histone deacetylase inhibitors and their therapeutic implications.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20071215

• Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment.

  Immunology 20071201

• Combined effects of histone deacetylase inhibitor and rituximab on non-Hodgkin's B-lymphoma cells apoptosis.

  Experimental hematology 20071201

• Epigenetic regulation of chemosensitivity to 5-fluorouracil and cisplatin by zebularine in oral squamous cell carcinoma.

  International journal of oncology 20071201

• Anti-estrogenic actions of histone deacetylase inhibitors in MCF-7 breast cancer cells.

  Endocrine-related cancer 20071201

• Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.

  Cancer research 20071201

• Epigenetic regulation as a new target for breast cancer therapy.

  Cancer investigation 20071201

• Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.

  Molecular cancer therapeutics 20071201

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20071201

• Update on the treatment of cutaneous T-cell lymphoma (CTCL): Focus on vorinostat.

  Biologics : targets & therapy 20071201

• Targeted therapies in the management of metastatic bladder cancer.

  Biologics : targets & therapy 20071201

• R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies.

  British journal of cancer 20071119

• Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.

  Bioorganic & medicinal chemistry letters 20071115

• Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues.

  Bioorganic & medicinal chemistry letters 20071115

• Modification of cap group in delta-lactam-based histone deacetylase (HDAC) inhibitors.

  Bioorganic & medicinal chemistry letters 20071115

• The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.

  Journal of medicinal chemistry 20071115

• Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.

  Neuron 20071108

• Histone deacetylase inhibitors induce cell death and enhance the apoptosis-inducing activity of TRAIL in Ewing's sarcoma cells.

  Journal of cancer research and clinical oncology 20071101

• Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells.

  Molecular cancer therapeutics 20071101

• Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro.

  Molecular cancer therapeutics 20071101

• Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells.

  Blood 20071001

• Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma.

  Hepatology (Baltimore, Md.) 20071001

• Comment on developmental toxicity evaluation on Vorinostat and relationship with HDAC inhibition.

  Birth defects research. Part B, Developmental and reproductive toxicology 20071001

• Histone deacetylase inhibitor-induced glycodelin enhances the initial step of implantation.

  Human reproduction (Oxford, England) 20071001

• Epigenetic alterations and cancer: new targets for therapy.

  IDrugs : the investigational drugs journal 20071001

• FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma.

  The oncologist 20071001

• Histone deacetylase inhibitors.

  Oncology (Williston Park, N.Y.) 20071001

• 2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.

  Journal of medicinal chemistry 20070906

• HDAC inhibitors: clinical update and mechanism-based potential.

  Biochemical pharmacology 20070901

• Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.

  Bioorganic & medicinal chemistry letters 20070901

• Trithiocarbonates: exploration of a new head group for HDAC inhibitors.

  Bioorganic & medicinal chemistry letters 20070901

• Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera.

  Bioorganic & medicinal chemistry letters 20070901

• The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells.

  International journal of oncology 20070901

• Histone deacetylase inhibitors selectively suppress expression of HDAC7.

  Molecular cancer therapeutics 20070901

• Vorinostat in cutaneous T-cell lymphoma.

  Drugs of today (Barcelona, Spain : 1998) 20070901

• Design of novel histone deacetylase inhibitors.

  Bioorganic & medicinal chemistry letters 20070815

• Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070815

• Histone deacetylase inhibitors: molecular mechanisms of action.

  Oncogene 20070813

• Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells.

  International journal of cancer 20070801

• Novel role of HDAC inhibitors in AML1/ETO AML cells: activation of apoptosis and phagocytosis through induction of annexin A1.

  Cell death and differentiation 20070801

• Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070720

• Aminosuberoyl hydroxamic acids (ASHAs): a potent new class of HDAC inhibitors.

  Bioorganic & medicinal chemistry letters 20070715

• Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070715

• Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model.

  Journal of neuro-oncology 20070701

• SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib.

  Apoptosis : an international journal on programmed cell death 20070701

• Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance.

  Blood 20070701

• Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma.

  Expert opinion on investigational drugs 20070701

• A brief primer on treatments of cutaneous T cell lymphoma, newly approved or late in development.

  Journal of drugs in dermatology : JDD 20070701

• Enhancement of cisplatin induced apoptosis by suberoylanilide hydroxamic acid in human oral squamous cell carcinoma cell lines.

  Biochemical pharmacology 20070615

• Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070615

• Histone deacetylase inhibitors--turning epigenic mechanisms of gene regulation into tools of therapeutic intervention in malignant and other diseases.

  Applied microbiology and biotechnology 20070601

• Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines.

  The journal of gene medicine 20070601

• Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.

  International journal of oncology 20070601

• Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver.

  Surgery 20070601

• Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro.

  The Journal of parasitology 20070601

• Bispyridinium dienes: histone deacetylase inhibitors with selective activities.

  Journal of medicinal chemistry 20070517

• Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.

  Bioorganic & medicinal chemistry letters 20070515

• Epigenetic combination therapy as a tumor-selective treatment approach for hepatocellular carcinoma.

  Cancer 20070515

• Discovery of epigenetically silenced genes in acute myeloid leukemias.

  Leukemia 20070501

• Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy.

  Cancer biology & therapy 20070501

• Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid.

  International journal of oncology 20070501

• In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species.

  Biological & pharmaceutical bulletin 20070501

• Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid.

  Bioorganic & medicinal chemistry letters 20070415

• Vorinostat for treatment of cutaneous manifestations of advanced primary cutaneous T-cell lymphoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070415

• Histone deacetylase inhibitors suppress natural killer cell cytolytic activity.

  FEBS letters 20070403

• Contribution of reactivated RUNX3 to inhibition of gastric cancer cell growth following suberoylanilide hydroxamic acid (vorinostat) treatment.

  Biochemical pharmacology 20070401

• Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents.

  British journal of pharmacology 20070401

• Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells.

  Molecular cancer therapeutics 20070401

• Targeted therapy and the T315I mutation in Philadelphia-positive leukemias.

  Haematologica 20070401

• [Histone deacetylase inhibitor SAHA induces inactivation of MAPK signaling and apoptosis in HL-60 cells].

  Zhongguo shi yan xue ye xue za zhi 20070401

• Disposition of vorinostat, a novel histone deacetylase inhibitor and anticancer agent, in preclinical species.

  Drug metabolism letters 20070401

• Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070328

• Vorinostat (Zolinza) for cutaneous T-Cell lymphoma.

  The Medical letter on drugs and therapeutics 20070312

• In vitro and in vivo histone deacetylase inhibitor therapy with suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer.

  Gynecologic oncology 20070301

• Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans.

  Bioorganic & medicinal chemistry letters 20070301

• Discovery and development of SAHA as an anticancer agent.

  Oncogene 20070226

• Synthesis and biological evaluation of the suberoylanilide hydroxamic acid (SAHA) beta-glucuronide and beta-galactoside for application in selective prodrug chemotherapy.

  Bioorganic & medicinal chemistry letters 20070215

• Histone deacetylase inhibitors stimulate cell migration in human endometrial adenocarcinoma cells through up-regulation of glycodelin.

  Endocrinology 20070201

• Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma.

  Leukemia 20070201

• Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070201

• Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague-Dawley rats and Dutch Belted rabbits.

  Birth defects research. Part B, Developmental and reproductive toxicology 20070201

• Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions.

  Molecular cancer therapeutics 20070201

• Systemic monotherapy vs combination therapy for CTCL: rationale and future strategies.

  Oncology (Williston Park, N.Y.) 20070201

• Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.

  Bioorganic & medicinal chemistry letters 20070115

• Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.

  Bioorganic & medicinal chemistry letters 20070115

• Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).

  Blood 20070101

• Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models.

  Scandinavian journal of gastroenterology 20070101

• The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070101

• HDAC inhibitors overcome first hurdle.

  Nature biotechnology 20070101

• Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug.

  Nature biotechnology 20070101

• Suberoylanilide hydroxamic acid (vorinostat) represses androgen receptor expression and acts synergistically with an androgen receptor antagonist to inhibit prostate cancer cell proliferation.

  Molecular cancer therapeutics 20070101

• Vorinostat.

  Nature reviews. Drug discovery 20070101

• c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through regulating Bcl-2/Bcl-xL expression.

  The international journal of biochemistry & cell biology 20070101

• New skin cancer drug.

  FDA consumer 20070101

• Modulating autophagy for therapeutic benefit.

  Autophagy 20070101

• HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway.

  The international journal of biochemistry & cell biology 20070101

• Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells.

  The international journal of biochemistry & cell biology 20070101

• The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo.

  Journal of translational medicine 20070101

• Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain.

  Molecular pharmacology 20061201

• A study to determine the effects of food and multiple dosing on the pharmacokinetics of vorinostat given orally to patients with advanced cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20061201

• Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells.

  Molecular cancer therapeutics 20061201

• Treatment of cutaneous T-cell lymphoma/mycosis fungoides.

  Dermatology nursing 20061201

• Stability studies of vorinostat and its two metabolites in human plasma, serum and urine.

  Journal of pharmaceutical and biomedical analysis 20061116

• Vorinostat approved for rare lymphoma.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20061115

• Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells.

  Oncology reports 20061101

• Suberoylanilide hydroxamic acid induces Akt-mediated phosphorylation of p300, which promotes acetylation and transcriptional activation of RelA/p65.

  The Journal of biological chemistry 20061020

• Epigenetic cancer therapy makes headway.

  Journal of the National Cancer Institute 20061018

• Synthesis of rigid trichostatin A analogs as HDAC inhibitors.

  Bioorganic & medicinal chemistry letters 20061015

• Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.

  Journal of medicinal chemistry 20061005

• PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter.

  Annals of hematology 20061001

• Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

  Nature chemical biology 20061001

• Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20061001

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20061001

• Exploring alternative Zn-binding groups in the design of HDAC inhibitors: squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA.

  Bioorganic & medicinal chemistry letters 20060915

• Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells.

  Cancer research 20060915

• Antitumor activity of suberoylanilide hydroxamic acid against thyroid cancer cell lines in vitro and in vivo.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060915

• Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma.

  Journal of neuro-oncology 20060901

• Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060901

• A liquid chromatography-electrospray ionization tandem mass spectrometric assay for quantitation of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamicacid, SAHA), and its metabolites in human serum.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060818

• The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, overcomes resistance of human breast cancer cells to Apo2L/TRAIL.

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