1496581-76-0 | GNE-3511

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$42.00	$30.00
5mg	95%	in stock	$105.00	$73.00
10mg	95%	in stock	$135.00	$95.00
25mg	95%	in stock	$206.00	$144.00
50mg	95%	in stock	$383.00	$268.00
100mg	95%	in stock	$463.00	$324.00

Description

• Catalog Number: AE81630
• Chemical Name: GNE-3511
• CAS Number: 1496581-76-0
• Molecular Formula: C23H26F2N6O
• Molecular Weight: 440.4889
• MDL Number: MFCD28502215
• SMILES: N#Cc1ccnc(c1)Nc1cc(cc(n1)N1CCC(C1)(F)F)C1CCN(CC1)C1COC1

Computed Properties

• Complexity: 689
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 3.2

Literature

• Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).

  Journal of medicinal chemistry 20151022

• Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

  Journal of medicinal chemistry 20150108

• Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.

  Journal of medicinal chemistry 20070111