15018-66-3 | Quinazolin-4-ylamine

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$39.00	$27.00
1g	95%	in stock	$67.00	$47.00
5g	95%	in stock	$155.00	$108.00
10g	95%	in stock	$251.00	$176.00
25g	95%	in stock	$496.00	$347.00
100g	95%	in stock	$1,505.00	$1,054.00

Description

• Catalog Number: AA75472
• Chemical Name: Quinazolin-4-ylamine
• CAS Number: 15018-66-3
• Molecular Formula: C8H7N3
• Molecular Weight: 145.1613
• MDL Number: MFCD00092016
• SMILES: Nc1ncnc2c1cccc2
• NSC Number: 288012

Computed Properties

• Complexity: 137
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.3

Literature

• Synthesis and evaluation of novel F-18 labeled 4-aminoquinazoline derivatives: potential PET imaging agents for tumor detection.

  Bioorganic & medicinal chemistry letters 20120715

• (E)-2-[2-(4-Chloro-benzyl-idene)hydrazin-1-yl]-4-{[3-(dimethyl-aza-nium-yl)prop-yl]amino}-quinazolin-1-ium bis-(perchlorate).

  Acta crystallographica. Section E, Structure reports online 20120501

• Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase.

  Bioorganic & medicinal chemistry letters 20120101

• Investigation of a novel molecular descriptor for the lead optimization of 4-aminoquinazolines as vascular endothelial growth factor receptor-2 inhibitors: application for quantitative structure-activity relationship analysis in lead optimization.

  Bioorganic & medicinal chemistry letters 20110301

• Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

  Bioorganic & medicinal chemistry letters 20110101

• Prediction of inhibitory activity of epidermal growth factor receptor inhibitors using grid search-projection pursuit regression method.

  PloS one 20110101

• Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells.

  BMC cancer 20110101

• Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists.

  Bioorganic & medicinal chemistry 20090101

• Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase.

  Bioorganic & medicinal chemistry 20080815

• ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1.

  Current neuropharmacology 20080301

• Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives.

  Bioorganic & medicinal chemistry 20071015

• The novel Src kinase inhibitor M475271 inhibits VEGF-induced vascular endothelial-cadherin and beta-catenin phosphorylation but increases their association.

  Journal of pharmacological sciences 20060901

• Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts.

  Molecular cancer therapeutics 20060801

• Evaluation of gefitinib for treatment of refractory solid tumors and central nervous system malignancies in pediatric patients.

  Cancer investigation 20060101

• A novel Src kinase inhibitor, M475271, inhibits VEGF-induced human umbilical vein endothelial cell proliferation and migration.

  Journal of pharmacological sciences 20050601

• SRC tyrosine kinase inhibitor, m475271, suppresses subcutaneous growth and production of lung metastasis via inhibition of proliferation, invasion, and vascularization of human lung adenocarcinoma cells.

  Clinical & experimental metastasis 20050101

• Efficient synthesis of 4-aminoquinazoline and thieno[3,2-d]pyrimidin-4-ylamine derivatives by microwave irradiation.

  Organic letters 20041209

• A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists.

  European journal of medicinal chemistry 20041201

• Synthesis and alpha 1-adrenoceptor antagonistic activity of some 4-amino-5,7-dimethyl-2-(substituted) aminopyrido (2,3-d) pyrimidines.

  Arzneimittel-Forschung 20020101