150454-82-3 | [1,2,4]Triazolo[1,5-a]quinoxaline-2-carboxylic acid, 4,5-dihydro-4-oxo-

Packsize	Purity	Availability	Price	Discounted Price
25mg	98%	in stock	$300.00	$210.00
50mg	98%	in stock	$435.00	$305.00
100mg	98%	in stock	$642.00	$449.00

Description

• Catalog Number: AA75786
• Chemical Name: [1,2,4]Triazolo[1,5-a]quinoxaline-2-carboxylic acid, 4,5-dihydro-4-oxo-
• CAS Number: 150454-82-3
• Molecular Formula: C10H6N4O3
• Molecular Weight: 230.1796
• MDL Number: MFCD28390420
• SMILES: OC(=O)c1nn2c(n1)c(=O)[nH]c1c2cccc1

Computed Properties

• Complexity: 362
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 0.8

Literature

• Synthesis and biological evaluation of novel 9-heteroaryl substituted 7-chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as (R,S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptor antagonists.

  Chemical & pharmaceutical bulletin 20080801

• 1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.

  Journal of medicinal chemistry 20051215

• Selectivity fields: comparative molecular field analysis (CoMFA) of the glycine/NMDA and AMPA receptors.

  Journal of medicinal chemistry 20030911