1506-47-4 | 2,6-Piperazinedione, 4,4'-(1,2-ethanediyl)bis-

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	2 weeks	$229.00	$160.00
250mg	95%	2 weeks	$413.00	$289.00
1g	95%	2 weeks	$987.00	$691.00

Description

• Catalog Number: AA75946
• Chemical Name: 2,6-Piperazinedione, 4,4'-(1,2-ethanediyl)bis-
• CAS Number: 1506-47-4
• Molecular Formula: C10H14N4O4
• Molecular Weight: 254.2426
• MDL Number: MFCD00446913
• SMILES: O=C1CN(CCN2CC(=O)NC(=O)C2)CC(=O)N1
• NSC Number: 129942

Computed Properties

• Complexity: 339
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: -1.8

Upstream Synthesis Route

4,4′-(1,2-Ethanediyl)bis[2,6-piperazinedione], commonly referred to as $name$, is a versatile compound extensively used in chemical synthesis. This compound serves as a valuable building block in various organic reactions, contributing to the development of novel molecules and materials. One key application of $name$ is its role as a bifunctional reagent in the formation of complex organic structures. By utilizing the reactive sites on both ends of the molecule, chemists can efficiently link multiple functional groups together, enabling the synthesis of intricate chemical compounds. Furthermore, the unique structural properties of $name$ make it especially useful in creating macrocyclic or bridged structures, where its ethylenediamine backbone facilitates the formation of cyclic motifs. As a result, $name$ plays a crucial role in the construction of diverse chemical frameworks with tailored functionalities, making it a valuable tool in the toolbox of synthetic chemists.

Literature

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  Anti-cancer agents in medicinal chemistry 20100901

• A mouse model for studying the interaction of bisdioxopiperazines with topoisomerase IIalpha in vivo.

  Molecular pharmacology 20071001

• Separation of bisdioxopiperazine- and vanadate resistance in topoisomerase II.

  Biochemical and biophysical research communications 20050902

• Probing the role of linker substituents in bisdioxopiperazine analogs for activity against wild-type and mutant human topoisomerase II alpha.

  Molecular pharmacology 20030501

• Evidence from studies with intact mammalian cells that merbarone and bis(dioxopiperazine)s are topoisomerase II poisons.

  Drug and chemical toxicology 20030201

• The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia.

  Experimental hematology 20021101