150780-67-9 | 5'-O-(4,4-Dimethoxytrityl)-2'-o-methyl-n-isobutyrylguanosine-3'-(2-cyanoethyl-n,n-diisopropyl)phosphoramidite

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$10.00	$7.00
250mg	98%	in stock	$25.00	$17.00
1g	98%	in stock	$70.00	$49.00

Description

• Catalog Number: AA76083
• Chemical Name: 5'-O-(4,4-Dimethoxytrityl)-2'-o-methyl-n-isobutyrylguanosine-3'-(2-cyanoethyl-n,n-diisopropyl)phosphoramidite
• CAS Number: 150780-67-9
• Molecular Formula: C45H56N7O9P
• Molecular Weight: 869.9414
• MDL Number: MFCD00792625
• SMILES: N#CCCOP(N(C(C)C)C(C)C)O[C@@H]1[C@@H](COC(c2ccc(cc2)OC)(c2ccc(cc2)OC)c2ccccc2)O[C@H]([C@@H]1OC)n1cnc2c1nc(NC(=O)C(C)C)[nH]c2=O

Upstream Synthesis Route

2'-OMe-ibu-G Phosphoramidite is a versatile reagent commonly used in chemical synthesis for the modification of nucleic acids. This phosphoramidite derivative contains a modified base, specifically a 2'-O-methyl group on the ribose sugar moiety and an isobutyl (ibu) group attached to the guanine base. These modifications enhance the stability and binding properties of the nucleic acid, making it ideal for various applications in molecular biology and medicinal chemistry.In chemical synthesis, 2'-OMe-ibu-G Phosphoramidite is employed in the solid-phase synthesis of modified oligonucleotides. By incorporating this phosphoramidite during the assembly of nucleic acid sequences, researchers can introduce specific chemical modifications at desired positions within the oligonucleotide chain. This enables the design and synthesis of custom nucleic acids with improved properties, such as enhanced stability, increased affinity for target molecules, and reduced susceptibility to enzymatic degradation.Furthermore, the use of 2'-OMe-ibu-G Phosphoramidite in chemical synthesis opens up possibilities for the development of novel nucleic acid-based therapeutics, diagnostic tools, and research probes. By precisely controlling the placement of modified bases, researchers can tailor the properties of nucleic acids to suit specific applications, such as gene silencing, aptamer development, or molecular recognition assays. This reagent plays a crucial role in expanding the toolbox of chemical modifications available for manipulating nucleic acids, paving the way for innovative advancements in molecular biology and biotechnology.