1509-34-8 | L-Allo-isoleucine

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$36.00	$25.00
250mg	98%	in stock	$43.00	$30.00
1g	98%	in stock	$123.00	$86.00
5g	98%	in stock	$538.00	$376.00
10g	98%	in stock	$968.00	$678.00

Description

• Catalog Number: AA76195
• Chemical Name: L-Allo-isoleucine
• CAS Number: 1509-34-8
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.1729
• MDL Number: MFCD00066446
• SMILES: CC[C@H]([C@@H](C(=O)O)N)C

Computed Properties

• Complexity: 103
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: -1.7

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• Single amino acid alteration between valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2.

  The Journal of biological chemistry 20100910

• TAQIB and I405V polymorphisms of CETP are moderately associated with obesity risk in the Chinese adult population.

  Acta diabetologica 20100901

• Plant defense elicitors: analogues of jasmonoyl-isoleucine conjugate.

  Phytochemistry 20100901

• Analysis of two polymorphisms of the manganese superoxide dismutase gene (Ile-58Thr and Ala-9Val) in patients with recurrent depressive disorder.

  Psychiatry research 20100830

• Subtype-specific conservation of isoleucine 309 in the envelope V3 domain is linked to immune evasion in subtype C HIV-1 infection.

  Virology 20100815

• Alternative splicing expands the repertoire of dominant JAZ repressors of jasmonate signaling.

  The Plant journal : for cell and molecular biology 20100801

• Development of a tandem time-of-flight mass spectrometer with an electrospray ionization ion source.

  Journal of mass spectrometry : JMS 20100801

• Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors.

  Molecules and cells 20100801

• A high-throughput multivariate optimization for the simultaneous enantioseparation and detection of barbiturates in micellar electrokinetic chromatography-mass spectrometry.

  Journal of chromatographic science 20100801

• Dietary limitation of isoleucine and valine in diets based on maize, soybean meal, and meat and bone meal for broiler chickens.

  British poultry science 20100801

• An in planta technique for cis-/trans-stereochemical analysis of jasmonoyl isoleucine.

  Journal of plant physiology 20100715

• Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase.

  Behavioural brain research 20100711

• A universal approach to the synthesis of noble metal nanodendrites and their catalytic properties.

  Angewandte Chemie (International ed. in English) 20100705

• An isoleucine-zipper motif enhances costimulation of human soluble trimeric GITR ligand.

  Cellular & molecular immunology 20100701

• Ligand-dependent conformation change reflects steric structure and interactions of a vitamin D receptor/ligand complex: a fragment molecular orbital study.

  The Journal of steroid biochemistry and molecular biology 20100701

• Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum DeltailvA DeltapanB ilvNM13 (pECKAilvBNC).

  Journal of industrial microbiology & biotechnology 20100701

• Optimal methyl labeling for studies of supra-molecular systems.

  Journal of biomolecular NMR 20100701

• Discrimination of isobaric leucine and isoleucine residues and analysis of post-translational modifications in peptides by MALDI in-source decay mass spectrometry combined with collisional cooling.

  Analytical chemistry 20100701

• The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20100701

• Crystallization and preliminary X-ray diffraction analysis of the Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase I86A mutant.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20100701

• Mutagenesis studies of neuropeptide S identify a suitable peptide tracer for neuropeptide S receptor binding studies and peptides selectively activating the I(107) variant of human neuropeptide S receptor.

  European journal of pharmacology 20100610

• Determination of isoleucine side-chain conformations in ground and excited states of proteins from chemical shifts.

  Journal of the American Chemical Society 20100609

• A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia.

  Molecular psychiatry 20100601

• Molecular determinants of Kv1.5 channel block by diphenyl phosphine oxide-1.

  Journal of molecular and cellular cardiology 20100601

• Maple syrup urine disease: further evidence that newborn screening may fail to identify variant forms.

  Molecular genetics and metabolism 20100601

• Metabolic pathways and fermentative production of L-aspartate family amino acids.

  Biotechnology journal 20100601

• Significance of the amyloidogenic transthyretin Val 122 Ile allele in African Americans in the Arteriosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies.

  American heart journal 20100501

• Topological frustration in beta alpha-repeat proteins: sequence diversity modulates the conserved folding mechanisms of alpha/beta/alpha sandwich proteins.

  Journal of molecular biology 20100430

• An Organocatalyzed enantioselective synthesis of (2S,3R,4S)-4-hydroxyisoleucine and its stereoisomers.

  The Journal of organic chemistry 20100416

• MGMT Ile143Val polymorphism, dietary factors and the risk of breast, colorectal and prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk study.

  DNA repair 20100404

• HER2 codon 655 polymorphism is associated with advanced uterine cervical carcinoma.

  Clinical biochemistry 20100401

• Structural and dynamic properties of a new amyloidogenic chicken cystatin mutant I108T.

  Journal of biomolecular structure & dynamics 20100401

• The recognition of gammadelta TCR to protein antigen does not depend on the hydrophobic I97 residue of CDR3delta.

  International immunology 20100401

• The effects of branched-chain amino acid interactions on growth performance, blood metabolites, enzyme kinetics and transcriptomics in weaned pigs.

  The British journal of nutrition 20100401

• Manganese superoxide dismutase (MnSOD) gene (Ala-9Val, Ile58Thr) polymorphism in patients with age-related macular degeneration (AMD).

  Medical science monitor : international medical journal of experimental and clinical research 20100401

• Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2.

  Brain : a journal of neurology 20100401

• The genuine ligand of a jasmonic acid receptor: improved analysis of jasmonates is now required.

  Plant signaling & behavior 20100401

• Globular structure of a human immunodeficiency virus-1 protease (1DIFA dimer) in an effective solvent medium by a Monte Carlo simulation.

  The Journal of chemical physics 20100328

• Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta.

  Biochemistry 20100323

• Diastereoselective allylstannane additions to (S)-5,6-dihydro-2H-5-phenyloxazin-2-one. A concise synthesis of (S)-beta-methylisoleucine.

  Organic letters 20100319

• Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and a novel mutation, Ile346Ser, in PANK2: clinical features and (99m)Tc-ECD brain perfusion SPECT findings.

  Journal of the neurological sciences 20100315

• Comprehensive and cost-effective NMR spectroscopy of methyl groups in large proteins.

  Journal of the American Chemical Society 20100310

• Combined dissolved oxygen and pH control strategy to improve the fermentative production of L-isoleucine by Brevibacterium lactofermentum.

  Bioprocess and biosystems engineering 20100301

• Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin.

  Microbiology (Reading, England) 20100301

• Isoleucine/leucine2 is essential for chemoattractant activity of beta-defensin Defb14 through chemokine receptor 6.

  Molecular immunology 20100301

• S1P receptor mediated activity of FTY720 phosphate mimics.

  Bioorganic & medicinal chemistry letters 20100301

• Predominant (S)-enantioselective inclusion of aryl methyl sulfoxides by (S)-isoleucyl-(S)-phenylglycines.

  The Journal of organic chemistry 20100205

• Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers.

  Journal of cancer research and clinical oncology 20100201

• Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.

  Parkinsonism & related disorders 20100201

• Alternative isoleucine synthesis pathway in cyanobacterial species.

  Microbiology (Reading, England) 20100201

• A 2-oxoacid dehydrogenase complex of Haloferax volcanii is essential for growth on isoleucine but not on other branched-chain amino acids.

  Microbiology (Reading, England) 20100201

• A tomato enzyme synthesizes (+)-7-iso-jasmonoyl-L-isoleucine in wounded leaves.

  Planta 20100201

• Epidermal triglyceride levels are correlated with severity of ichthyosis in Dorfman-Chanarin syndrome.

  Journal of dermatological science 20100201

• The GSTP1 Ile105 Val polymorphism modifies the metabolism of toluene di-isocyanate.

  Pharmacogenetics and genomics 20100201

• Peptide de novo sequencing using 157 nm photodissociation in a tandem time-of-flight mass spectrometer.

  Analytical chemistry 20100201

• Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice.

  Natural product research 20100201

• Uncombable hair and atopic dermatitis in a case of trichodento-osseous syndrome.

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20100201

• Specific formation of negative ions from leucine and isoleucine molecules.

  The Journal of chemical physics 20100107

• Polymorphism Val103Ile of the melanocortin-4 receptor gene in the Serbian population.

  Molecular biology reports 20100101

• Clinical, neuropathologic, and biochemical profile of the amyloid precursor protein I716F mutation.

  Journal of neuropathology and experimental neurology 20100101

• The role of Ile476 in the structural stability and substrate binding of human cytochrome P450 2C8.

  The protein journal 20100101

• Modulation of the SecY channel permeability by pore mutations and trivalent cations.

  Channels (Austin, Tex.) 20100101

• Proline-rich domain plays a crucial role in extracellular stimuli-responsive translocation of a Cdc42 guanine nucleotide exchange factor, FGD1.

  Biological & pharmaceutical bulletin 20100101

• The role of jasmonates in floral nectar secretion.

  PloS one 20100101

• Degradation kinetics of branched-chain amino acids in subcritical water.

  Bioscience, biotechnology, and biochemistry 20100101

• Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes.

  PloS one 20100101

• Acrodermatitis acidemica: experience of 5 years in Andalusia.

  Pediatric dermatology 20100101

• The effect of aspartate-lysine-isoleucine and aspartate-arginine-tyrosine mutations on the expression and activity of vasopressin V2 receptor gene.

  Iranian biomedical journal 20100101

• The side-on copper(I) nitrosyl geometry in copper nitrite reductase is due to steric interactions with isoleucine-257.

  Inorganic chemistry 20091221

• I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule.

  Biochemical and biophysical research communications 20091218

• A novel l-isoleucine hydroxylating enzyme, l-isoleucine dioxygenase from Bacillus thuringiensis, produces (2S,3R,4S)-4-hydroxyisoleucine.

  Biochemical and biophysical research communications 20091218

• The standardized ileal digestible isoleucine-to-lysine requirement ratio may be less than fifty percent in eleven- to twenty-three-kilogram piglets.

  Journal of animal science 20091201

• Relative solvation free energies calculated using an ab initio QM/MM-based free energy perturbation method: dependence of results on simulation length.

  Journal of computer-aided molecular design 20091201

• An unusual melting curve on a LightCycler due to a new mutation in methylenetetrahydrofolate reductase.

  Genetic testing and molecular biomarkers 20091201

• Identification of hydrophobic amino acids required for lipid activation of C. elegans CTP:phosphocholine cytidylyltransferase.

  Archives of biochemistry and biophysics 20091201

• Substitution of Ile(707) for Leu in Klentaq DNA polymerase reduces the amplification capacity of the enzyme.

  Prilozi 20091201

• Assignment of Ile, Leu, and Val methyl correlations in supra-molecular systems: an application to aspartate transcarbamoylase.

  Journal of the American Chemical Society 20091118

• Genetic and biochemical analysis of the interaction of Bacillus subtilis CodY with branched-chain amino acids.

  Journal of bacteriology 20091101

• The Ile13 residue of microcin J25 is essential for recognition by the receptor FhuA, but not by the inner membrane transporter SbmA.

  FEMS microbiology letters 20091101

• Evidence for potential functionality of nuclearly-encoded humanin isoforms.

  Genomics 20091001

• Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD).

  Biochimica et biophysica acta 20091001

• A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome.

  The Journal of clinical endocrinology and metabolism 20091001

• Structures and properties of a diastereoisomeric molecular compound of (2S,3S)- and (2R,3S)-N-acetyl-2-amino-3-methylpentanoic acids.

  Bioscience, biotechnology, and biochemistry 20091001

• Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.

  Molecular cell 20090924

• D-amino acids govern stationary phase cell wall remodeling in bacteria.

  Science (New York, N.Y.) 20090918

• The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.

  Human molecular genetics 20090915

• Resonance Raman spectra of an O2-binding H-NOX domain reveal heme relaxation upon mutation.

  Biochemistry 20090915

• Val1483Ile in FASN gene is linked to central obesity and insulin sensitivity in adult white men.

  Obesity (Silver Spring, Md.) 20090901

• Polymorphisms and haplotype analysis of IL-4Ralpha Q576R and I75V in patients with penicillin allergy.

  European journal of clinical pharmacology 20090901

• A rapid wound signal activates the systemic synthesis of bioactive jasmonates in Arabidopsis.

  The Plant journal : for cell and molecular biology 20090901

• Sequence analysis of the novel HLA-Cw*08 variant allele, Cw*0820, in a Chinese Han individual.

  Tissue antigens 20090901

• Hot electron capture dissociation distinguishes leucine from isoleucine in a novel hemoglobin variant, Hb Askew, beta54(D5)Val-->Ile.

  Journal of the American Society for Mass Spectrometry 20090901

• Arabidopsis methionine gamma-lyase is regulated according to isoleucine biosynthesis needs but plays a subordinate role to threonine deaminase.

  Plant physiology 20090901

• Limitations of dietary isoleucine and valine in broiler chick diets.

  Poultry science 20090901

• The wound hormone jasmonate.

  Phytochemistry 20090901

• The power of mutants for investigating jasmonate biosynthesis and signaling.

  Phytochemistry 20090901

• Novel RUNX2 mutations in Chinese individuals with cleidocranial dysplasia.

  Journal of dental research 20090901

• KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation.

  Blood 20090820

• A single mutation at residue 25 populates the folding intermediate of E. coli RNase H and reveals a highly dynamic partially folded ensemble.

  Journal of molecular biology 20090814

• Ileal digestibility and endogenous flow of minerals and amino acids: responses to dietary phytic acid in piglets.

  The British journal of nutrition 20090801

• Estimation of the optimum ratio of standardized ileal digestible isoleucine to lysine for eight- to twenty-five-kilogram pigs in diets containing spray-dried blood cells or corn gluten feed as a protein source.

  Journal of animal science 20090801

• Metastable atom-activated dissociation mass spectrometry: leucine/isoleucine differentiation and ring cleavage of proline residues.

  Journal of mass spectrometry : JMS 20090801

• The jasmonate receptor: protein modeling and photoaffinity labeling reveal that the CORONATINE INSENSITIVE1 protein binds jasmonoyl-isoleucine and coronatine.

  The Plant cell 20090801

• The Arabidopsis CORONATINE INSENSITIVE1 protein is a jasmonate receptor.

  The Plant cell 20090801

• Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans.

  The Biochemical journal 20090612

• Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20090601

• Association of the growth hormone receptor gene polymorphisms with mandibular height in a Korean population.

  Archives of oral biology 20090601

• Homocysteine editing and growth inhibition in Escherichia coli.

  Microbiology (Reading, England) 20090601

• Thrombin-mediated impairment of fibroblast growth factor-2 activity.

  The FEBS journal 20090601

• Independent NF1 and PTPN11 mutations in a family with neurofibromatosis-Noonan syndrome.

  American journal of medical genetics. Part A 20090601

• Association between Toll-like receptors 4 and 2 gene polymorphisms with chronic allograft nephropathy in Turkish children.

  Transplantation proceedings 20090601

• Recall rate and positive predictive value of MSUD screening is not influenced by hydroxyproline.

  European journal of pediatrics 20090501

• Familial parkinsonism: study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes.

  Parkinsonism & related disorders 20090501

• A single conserved leucine residue on the first intracellular loop regulates ER export of G protein-coupled receptors.

  Traffic (Copenhagen, Denmark) 20090501

• (+)-7-iso-Jasmonoyl-L-isoleucine is the endogenous bioactive jasmonate.

  Nature chemical biology 20090501

• A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidase.

  The Biochemical journal 20090415

• Review article: hyperammonaemic and catabolic consequences of upper gastrointestinal bleeding in cirrhosis.

  Alimentary pharmacology & therapeutics 20090415

• Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue.

  The Journal of biological chemistry 20090410

• Structural basis of glyphosate resistance resulting from the double mutation Thr97 -> Ile and Pro101 -> Ser in 5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli.

  The Journal of biological chemistry 20090410

• Effects of gabapentin and pregabalin on K+-evoked 3H-GABA and 3H-glutamate release from human neocortical synaptosomes.

  Naunyn-Schmiedeberg's archives of pharmacology 20090401

• Cell cycle-dependent effects of 3,3'-diindolylmethane on proliferation and apoptosis of prostate cancer cells.

  Journal of cellular physiology 20090401

• Amino acids levels and lipid peroxidation in maple syrup urine disease patients.

  Clinical biochemistry 20090401

• Relationship between GSTP1 Ile(105)Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity.

  Annals of oncology : official journal of the European Society for Medical Oncology 20090401

• Methyl-detected 'out-and-back' NMR experiments for simultaneous assignments of Alabeta and Ilegamma2 methyl groups in large proteins.

  Journal of biomolecular NMR 20090401

• Selective backbone labelling of ILV methyl labelled proteins.

  Journal of biomolecular NMR 20090401

• Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease.

  Brain : a journal of neurology 20090401

• Tryptophan as a three-way switch in regulating the function of the secretory signalling glycoprotein (SPS-40) from mammary glands: structure of SPS-40 complexed with 2-methylpentane-2,4-diol at 1.6 A resolution.

  Acta crystallographica. Section D, Biological crystallography 20090401

• 4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome.

  Current opinion in investigational drugs (London, England : 2000) 20090401

• RNA editing of the GABA(A) receptor alpha3 subunit alters the functional properties of recombinant receptors.

  Neuroscience research 20090401

• TLR4 as a risk factor for periodontal disease: a reappraisal.

  Journal of clinical periodontology 20090401

• I405V and -629C/A polymorphisms of the cholesteryl ester transfer protein gene in patients with coronary artery disease.

  Iranian biomedical journal 20090401

• [Possible relation of BDNF and GDNF to neuropsychiatric disorders].

  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20090401

• Vibrational analysis of amino acids and short peptides in hydrated media. IV. Amino acids with hydrophobic side chains: L-alanine, L-valine, and L-isoleucine.

  The journal of physical chemistry. B 20090312

• Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro.

  Nutrition (Burbank, Los Angeles County, Calif.) 20090301

• Procarboxypeptidase U (TAFI) and the Thr325Ile proCPU polymorphism in patients with hereditary mucocutaneous hemorrhages.

  Clinica chimica acta; international journal of clinical chemistry 20090301

• Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia.

  Metabolic brain disease 20090301

• Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090225

• Metabolic engineering of the L-valine biosynthesis pathway in Corynebacterium glutamicum using promoter activity modulation.

  Journal of biotechnology 20090205

• (S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.

  Bioorganic & medicinal chemistry letters 20090201

• An efficient protocol for the complete incorporation of methyl-protonated alanine in perdeuterated protein.

  Journal of biomolecular NMR 20090201

• A case of ALS-FTD in a large FALS pedigree with a K17I ANG mutation.

  Neurology 20090120

• Evaluation of channel function after alteration of amino acid residues at the pore center of KCNQ1 channel.

  Biochemical and biophysical research communications 20090116

• The effect of fenugreek 4-hydroxyisoleucine on liver function biomarkers and glucose in diabetic and fructose-fed rats.

  Phytotherapy research : PTR 20090101

• Glial metabolism of isoleucine.

  Neurochemical research 20090101

• Jasmonate passes muster: a receptor and targets for the defense hormone.

  Annual review of plant biology 20090101

• Stabilization of neutral NH2-R-COOH form of the antihypertensive peptides L-Valyl-L-Prolyl-L-Proline and L-Isoleucyl-L-Prolyl-L-Proline.

  Protein and peptide letters 20090101

• Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.

  Channels (Austin, Tex.) 20090101

• Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 20090101

• Acrodermatitis enteropathica-like eruption in metabolic disorders: acrodermatitis dysmetabolica is proposed as a better term.

  Pediatric dermatology 20090101

• Cu(II)-catalyzed reactions in ternary [Cu(AA)(AA - H)]+ complexes (AA = Gly, Ala, Val, Leu, Ile, t-Leu, Phe).

  European journal of mass spectrometry (Chichester, England) 20090101

• Carbohydrate metabolism and carbon fixation in Roseobacter denitrificans OCh114.

  PloS one 20090101

• Terahertz spectra and normal mode analysis of the crystalline VA class dipeptide nanotubes.

  Journal of the American Chemical Society 20081231

• New cyclic tetrapeptides from Nonomuraea sp. TA-0426 that inhibit glycine transporter type 1 (GlyT1).

  Bioorganic & medicinal chemistry letters 20081215

• Bag-1M is a component of the in vivo DNA-glucocorticoid receptor complex at hormone-regulated promoter.

  Journal of molecular biology 20081205

• Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase.

  Protein science : a publication of the Protein Society 20081201

• Maple syrup urine disease (MSUD)--clinical profile of 47 Filipino patients.

  Journal of inherited metabolic disease 20081201

• Interplant communication: airborne methyl jasmonate is essentially converted into JA and JA-Ile activating jasmonate signaling pathway and VOCs emission.

  Biochemical and biophysical research communications 20081128

• Point mutations in the barley HvHAK1 potassium transporter lead to improved K+-nutrition and enhanced resistance to salt stress.

  FEBS letters 20081126

• A novel dominant mutation of the Nav1.4 alpha-subunit domain I leading to sodium channel myotonia.

  Neurology 20081118

• Neonatal hypotonia can be a sodium channelopathy: recognition of a new phenotype.

  Neurology 20081118

• Allosteric regulation of Bacillus subtilis threonine deaminase, a biosynthetic threonine deaminase with a single regulatory domain.

  Biochemistry 20081111

• Structural and kinetic analysis of pyrrolidine-based inhibitors of the drug-resistant Ile84Val mutant of HIV-1 protease.

  Journal of molecular biology 20081107

• The varitint-waddler mouse phenotypes and the TRPML3 ion channel mutation: cause and consequence.

  Pflugers Archiv : European journal of physiology 20081101

• Isoleucine and valine supplementation of a low-protein corn-wheat-soybean meal-based diet for piglets: growth performance and nitrogen balance.

  Journal of animal science 20081101

• Protein synthesis is severely diminished following a simulated upper GI bleed in patients with cirrhosis.

  Journal of hepatology 20081101

• Effects of branched-chain amino acids supplementation on physiological and psychological performance during an offshore sailing race.

  European journal of applied physiology 20081101

• Aggregation and conformational studies on a pentapeptide derivative.

  Biochimica et biophysica acta 20081101

• Biosynthetic and environmental effects on the stable carbon isotopic compositions of anteiso- (3-methyl) and iso- (2-methyl) alkanes in tobacco leaves.

  Phytochemistry 20081101

• Cloning and functional analysis of novel short-chain cis-prenyltransferases.

  Biochemical and biophysical research communications 20081031

• Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery disease.

  Journal of the American College of Cardiology 20081021

• alpha-Isopropylmalate, a leucine biosynthesis intermediate in yeast, is transported by the mitochondrial oxalacetate carrier.

  The Journal of biological chemistry 20081017

• Independently silencing two photosynthetic proteins in Nicotiana attenuata has different effects on herbivore resistance.

  Plant physiology 20081001

• Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy.

  AJNR. American journal of neuroradiology 20081001

• Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor.

  Molecular cancer therapeutics 20081001

• Calcium, nucleotide, and actin affect the interaction of mammalian Myo1c with its light chain calmodulin.

  Biochemistry 20080923

• Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance.

  Diabetes, obesity & metabolism 20080901

• Synthesis and characterization of synthetic analogs of cinnacidin, a novel phytotoxin from Nectria sp.

  Pest management science 20080901

• A critical role of two positively charged amino acids in the Jas motif of Arabidopsis JAZ proteins in mediating coronatine- and jasmonoyl isoleucine-dependent interactions with the COI1 F-box protein.

  The Plant journal : for cell and molecular biology 20080901

• CYP1A1 Ile462Val and GSTT1 modify the effect of cord blood cotinine on neurodevelopment at 2 years of age.

  Neurotoxicology 20080901

• Auxotrophy accounts for nodulation defect of most Sinorhizobium meliloti mutants in the branched-chain amino acid biosynthesis pathway.

  Molecular plant-microbe interactions : MPMI 20080901

• HER-2/neu Ile655Val polymorphism and the risk of breast cancer.

  Annals of the New York Academy of Sciences 20080901

• Obesity and eating behaviour in a three-generation Chilean family with carriers of the Thrl50Ile mutation in the melanocortin-4 receptor gene.

  Journal of physiology and biochemistry 20080901

• Glycogen resynthesis and exercise performance with the addition of fenugreek extract (4-hydroxyisoleucine) to post-exercise carbohydrate feeding.

  Amino acids 20080801

• Autosomal dominant nocturnal frontal lobe epilepsy and mild memory impairment associated with CHRNB2 mutation I312M in the neuronal nicotinic acetylcholine receptor.

  Epilepsy & behavior : E&B 20080801

• Jasmonate perception regulates jasmonate biosynthesis and JA-Ile metabolism: the case of COI1 in Nicotiana attenuata.

  Plant & cell physiology 20080801

• Synthesis and biological evaluation of a focused library of beauveriolides.

  Bioorganic & medicinal chemistry letters 20080801

• Synthesis of hydantoin analogues of (2S,3R,4S)-4-hydroxyisoleucine with insulinotropic properties.

  Bioorganic & medicinal chemistry letters 20080801

• GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia.

  Analytical and bioanalytical chemistry 20080801

• The T244I variant of the interleukin-7 receptor-alpha gene and multiple sclerosis.

  Tissue antigens 20080801

• Inhibition of CD26/dipeptidyl peptidase IV enhances CCL11/eotaxin-mediated recruitment of eosinophils in vivo.

  Journal of immunology (Baltimore, Md. : 1950) 20080715

• Common CX3CR1 alleles are associated with a reduced risk of headaches.

  Headache 20080701

• Effects of L-isoleucine and L-valine on hot flushes and serum homocysteine: a randomized controlled trial.

  Obstetrics and gynecology 20080701

• Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase.

  Biochemistry 20080610

• Proximal mutations at the type 1 copper site of CotA laccase: spectroscopic, redox, kinetic and structural characterization of I494A and L386A mutants.

  The Biochemical journal 20080601

• Early diagnosis of maple syrup urine disease using polymerase chain reaction-based mutation detection.

  Pediatrics international : official journal of the Japan Pediatric Society 20080601

• Cysteine-scanning analysis of putative helix XII in the YgfO xanthine permease: ILE-432 and ASN-430 are important.

  The Journal of biological chemistry 20080516

• Crystal structure of STS042, a stand-alone RAM module protein, from hyperthermophilic archaeon Sulfolobus tokodaii strain 7.

  Proteins 20080515

• The role of JAR1 in Jasmonoyl-L: -isoleucine production during Arabidopsis wound response.

  Planta 20080501

• Heart transplantation for homozygous familial transthyretin (TTR) V122I cardiac amyloidosis.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20080501

• Myotilin overexpression enhances myopathology in the LGMD1A mouse model.

  Muscle & nerve 20080501

• Diversification of an ancient theme: hydroxynitrile glucosides.

  Phytochemistry 20080501

• Analysis of the regulatory motifs in eukaryotic initiation factor 4E-binding protein 1.

  The FEBS journal 20080501

• A residue at the cytoplasmic entrance of BK-type channels regulating single-channel opening by its hydrophobicity.

  Biophysical journal 20080501

• Autosomal-dominant guanosine triphosphate cyclohydrolase I deficiency with novel mutations.

  Pediatric neurology 20080501

• Biosynthesis of stenusine.

  Journal of natural products 20080501

• Transmembrane segment 6 of the Glut1 glucose transporter is an outer helix and contains amino acid side chains essential for transport activity.

  The Journal of biological chemistry 20080425

• Autoproteolytic cleavage and activation of human acid ceramidase.

  The Journal of biological chemistry 20080425

• Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150).

  The Journal of biological chemistry 20080425

• High-resolution structure of a self-assembly-competent form of a hydrophobic peptide captured in a soluble beta-sheet scaffold.

  Journal of molecular biology 20080425

• Increasing complexity of a diterpene synthase reaction with a single residue switch.

  Journal of the American Chemical Society 20080423

• Molecular basis explanation for imatinib resistance of BCR-ABL due to T315I and P-loop mutations from molecular dynamics simulations.

  Cancer 20080415

• Conserved active site residues limit inhibition of a copper-containing nitrite reductase by small molecules.

  Biochemistry 20080415

• Influence of L-isoleucine and pantothenate auxotrophy for L-valine formation in Corynebacterium glutamicum revisited by metabolome analyses.

  Bioprocess and biosystems engineering 20080401

• Association of missense variants of the PRKC, apoptosis, WT1, regulator (PAWR) gene with schizophrenia.

  Progress in neuro-psychopharmacology & biological psychiatry 20080401

• Mutation T/C,Ile 131 of the gene encoding the alfa subunit of the human Gs protein and predisposition to vasovagal syncope.

  Circulation journal : official journal of the Japanese Circulation Society 20080401

• Structure of acostatin, a dimeric disintegrin from Southern copperhead (Agkistrodon contortrix contortrix), at 1.7 A resolution.

  Acta crystallographica. Section D, Biological crystallography 20080401

• Novel CYP4V2 gene mutation in a Mexican patient with Bietti's crystalline corneoretinal dystrophy.

  Current eye research 20080401

• Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding.

  The Journal of biological chemistry 20080328

• Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis.

  Journal of the National Cancer Institute 20080319

• A single acyl-CoA dehydrogenase is required for catabolism of isoleucine, valine and short-chain fatty acids in Aspergillus nidulans.

  Fungal genetics and biology : FG & B 20080301

• Amino acid residues involved in stereoselective inhibition of cholinesterases with bambuterol.

  Archives of biochemistry and biophysics 20080301

• Second-tier test for quantification of alloisoleucine and branched-chain amino acids in dried blood spots to improve newborn screening for maple syrup urine disease (MSUD).

  Clinical chemistry 20080301

• Targeting of mitochondrial Saccharomyces cerevisiae Ilv5p to the cytosol and its effect on vicinal diketone formation in brewing.

  Applied microbiology and biotechnology 20080301

• Acute and chronic treatment of L-isoleucine ameliorates glucose metabolism in glucose-intolerant and diabetic mice.

  Biological & pharmaceutical bulletin 20080301

• Chromogranin B and Secretogranin II in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations and in Alzheimer patients.

  Journal of Alzheimer's disease : JAD 20080301

• Critical role of Val-304 in conformational transitions that allow Ca2+ occlusion and phosphoenzyme turnover in the Ca2+ transport ATPase.

  The Journal of biological chemistry 20080208

• Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.

  Neurobiology of aging 20080201

• FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications.

  Blood 20080201

• A case-control study of the HER2 Ile655Val polymorphism and risk of breast cancer in Taiwan.

  Clinical biochemistry 20080201

• SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder.

  Psychiatric genetics 20080201

• Experimental evidence for three pheromone races of the scarab beetle Phyllophaga anxia (LeConte).

  Journal of chemical ecology 20080201

• Auxotrophy in natural isolate: minimal requirements for growth of the Antarctic psychrotrophic bacterium Pseudomonas syringae Lz4W.

  Journal of basic microbiology 20080201

• Association study of human MTH1 Ile45Thr polymorphism with sporadic Parkinson's disease.

  European neurology 20080101

• 2-Methylbutyryl-coenzyme A dehydrogenase deficiency: functional and molecular studies on a defect in isoleucine catabolism.

  Molecular genetics and metabolism 20080101

• Site-directed mutagenesis investigation of coupling properties of metal ion transport by DCT1.

  Biochimica et biophysica acta 20080101

• Differential modulation of K(+)-evoked (3)H-neurotransmitter release from human neocortex by gabapentin and pregabalin.

  Naunyn-Schmiedeberg's archives of pharmacology 20080101

• Simultaneous determination of blood glucose and isoleucine levels in rats after chronic alcohol exposure by microwave-assisted derivatization and isotope dilution gas chromatography/mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20080101

• Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade.

  Molecular pain 20080101

• [Spatial structure of isoleucine pentapeptides Glu-Phe-Leu-Arg-Ile-NH2 and Pro-Phe-Tyr-Arg-Ile-NH2].

  Biofizika 20080101

• Relation of glutathione S-transferase T1, M1 and P1 genotypes and breast cancer risk.

  Cell biochemistry and function 20080101

• The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.

  Neuromolecular medicine 20080101

• The effects of enhanced methionine synthesis on amino acid and anthocyanin content of potato tubers.

  BMC plant biology 20080101

• Functional role of Ile264 in CYP2C8: mutations affect haem incorporation and catalytic activity.

  Drug metabolism and pharmacokinetics 20080101

• Acrodermatitis enteropathica-like syndrome secondary to branched-chain amino acid deficiency in inborn errors of metabolism.

  Pediatric dermatology 20080101

• Ile481 from the guinea pig alpha-subunit plays a major role in the activation of ENaC by cpt-cAMP.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

• Sporadic desmoid tumor in an Ashkenazi patient homozygous for the APC*I1307K gene mutation.

  Acta oncologica (Stockholm, Sweden) 20080101

• Two new hemoglobin variants: Hb Sinai-Greenspring [beta34(B16)Val-->Ile, GTC > ATC] and Hb Sinai-Bel Air [beta53(D4)Ala-->Asp, GCT > GAT].

  Hemoglobin 20080101

• Dioxygen activation at non-heme diiron centers: oxidation of a proximal residue in the I100W variant of toluene/o-xylene monooxygenase hydroxylase.

  Biochemistry 20071225

• Caught in the Act: the 1.5 A resolution crystal structures of the HIV-1 protease and the I54V mutant reveal a tetrahedral reaction intermediate.

  Biochemistry 20071225

• Substitution of isoleucine L177 by histidine in Rhodobacter sphaeroides reaction center results in the covalent binding of PA bacteriochlorophyll to the L subunit.

  FEBS letters 20071222

• Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.

  International journal of cancer 20071215

• Ile178 of HIV-1 reverse transcriptase is critical for inhibiting the viral integrase.

  Biochemical and biophysical research communications 20071207

• Topology of the selectivity filter of a TRPV channel: rapid accessibility of contiguous residues from the external medium.

  American journal of physiology. Cell physiology 20071201

• A new ATTR Phe64Ile mutation with late-onset multiorgan involvement.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20071201

• A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency.

  The FEBS journal 20071201

• First case of V281+I172N/V281L CYP21A2 genotype associated with congenital adrenal hyperplasia form. A case report from South Italy.

  Clinical biochemistry 20071201

• Distal Val346Ile mutation in inducible NO synthase promotes substrate-dependent NO confinement.

  Biochemistry 20071127

• Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.

  Structure (London, England : 1993) 20071113

• Conquering isoleucine auxotrophy of Escherichia coli BLR(DE3) to recombinantly produce spider silk proteins in minimal media.

  Biotechnology letters 20071101

• Fluorinated chloramphenicol acetyltransferase thermostability and activity profile: improved thermostability by a single-isoleucine mutant.

  Bioorganic & medicinal chemistry letters 20071101

• Multiplex PCR detection of GSTM1, GSTT1, and GSTP1 gene variants: simultaneously detecting GSTM1 and GSTT1 gene copy number and the allelic status of the GSTP1 Ile105Val genetic variant.

  The Journal of molecular diagnostics : JMD 20071101

• Inhibitory effect of aroma on the bitterness of branched-chain amino acid solutions.

  Chemical & pharmaceutical bulletin 20071101

• Probing supramolecular structure from measurement of methyl (1)H-(13)C residual dipolar couplings.

  Journal of the American Chemical Society 20071024

• The ATP-binding site of protein kinase CK2 holds a positive electrostatic area and conserved water molecules.

  Chembiochem : a European journal of chemical biology 20071015

• Effects of bioactive peptides isoleucine-proline-proline (IPP), valine-proline-proline (VPP) and leucine-lysine-proline (LKP) on gene expression of osteoblasts differentiated from human mesenchymal stem cells.

  The British journal of nutrition 20071001

• Interferon-alpha or homoharringtonine as salvage treatment for chronic myeloid leukemia patients who acquire the T315I BCR-ABL mutation.

  Blood 20071001

• Analysis of the putative substrate binding region of hyperthermophilic endoglucanase from Pyrococcus horikoshii.

  Bioscience, biotechnology, and biochemistry 20071001

• A structural code for discriminating between transcription signals revealed by the feast/famine regulatory protein DM1 in complex with ligands.

  Structure (London, England : 1993) 20071001

• [Advances in the diagnosis and treatment of maple syrup urine disease: experience in Galicia (Spain)].

  Anales de pediatria (Barcelona, Spain : 2003) 20071001

• [Mitochondrial acetoacetyl-CoA thiolase deficiency: neonatal onset].

  Anales de pediatria (Barcelona, Spain : 2003) 20071001

• Molecular characterization of cold adaptation based on ortholog protein sequences from Vibrionaceae species.

  Extremophiles : life under extreme conditions 20070901

• A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity.

  Human reproduction (Oxford, England) 20070901

• Microscale solution isoelectric focusing as an effective strategy enabling containment of hemeoglobin-derived products for high-resolution gel-based analysis of the Plasmodium falciparum proteome.

  Journal of proteome research 20070901

• Steric interactions stabilize the signaling state of the LOV2 domain of phototropin 1.

  Biochemistry 20070814

• JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling.

  Nature 20070809

• A novel strategy for enzymatic synthesis of 4-hydroxyisoleucine: identification of an enzyme possessing HMKP (4-hydroxy-3-methyl-2-keto-pentanoate) aldolase activity.

  FEMS microbiology letters 20070801

• Erythrocyte glutathione peroxidase activity and plasma selenium concentration are reduced in maple syrup urine disease patients during treatment.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20070801

• Heterozygosity for ABCA3 mutations modifies the severity of lung disease associated with a surfactant protein C gene (SFTPC) mutation.

  Pediatric research 20070801

• Development of micellar electro kinetic chromatography for the separation and quantitation of L-valine, L-leucine, L-isoleucin and L-phenylalanine in human plasma and comparison with HPLC.

  Pakistan journal of biological sciences : PJBS 20070801

• Increase in bioluminescence intensity of firefly luciferase using genetic modification.

  Analytical biochemistry 20070715

• Stereochemical integrity of oxazolone ring-containing jadomycins.

  Chembiochem : a European journal of chemical biology 20070709

• Amino acids: aspects of impurity profiling by means of CE.

  Electrophoresis 20070701

• The conserved isoleucine-valine-phenylalanine motif couples activation state and endocytic functions of beta-arrestins.

  Traffic (Copenhagen, Denmark) 20070701

• TLR2 Arg753Gly, TLR4 Asp299Gly and Thr399Ile gene polymorphisms are not associated with chronic periodontitis in a Turkish population.

  Journal of clinical periodontology 20070701

• HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102.

  Tissue antigens 20070701

• TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide.

  Journal of immunology (Baltimore, Md. : 1950) 20070701

• Synthesis of 4-hydroxyisoleucine by the aldolase-transaminase coupling reaction and basic characterization of the aldolase from Arthrobacter simplex AKU 626.

  Bioscience, biotechnology, and biochemistry 20070701

• Regulation of G protein-coupled cAMP receptor activation by a hydrophobic residue in transmembrane helix 3.

  Molecular microbiology 20070701

• Backbone and sidechain methyl Ile (delta1), Leu and Val resonance assignments of the catalytic domain of the yeast mRNA decapping enzyme, Dcp2.

  Biomolecular NMR assignments 20070701

• CmaE: a transferase shuttling aminoacyl groups between carrier protein domains in the coronamic acid biosynthetic pathway.

  Biochemistry 20070626

• Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy.

  Journal of immunology (Baltimore, Md. : 1950) 20070615

• Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.

  American journal of physiology. Endocrinology and metabolism 20070601

• Anti-Müllerian hormone and anti-Müllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women.

  Human reproduction (Oxford, England) 20070601

• The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes.

  Neurochemistry international 20070601

• Patients with a sodium channel alpha 1 gene mutation show wide phenotypic variation.

  Epilepsy research 20070601

• Purification, crystallization and preliminary X-ray crystallographic analysis of branched-chain aminotransferase from Deinococcus radiodurans.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20070601

• [Primary hyperoxaluria in children in central Tunisia].

  La Tunisie medicale 20070601

• Acetylcholinesterase: mechanisms of covalent inhibition of wild-type and H447I mutant determined by computational analyses.

  Journal of the American Chemical Society 20070523

• Force-induced prolyl cis-trans isomerization in elastin-like polypeptides.

  Journal of the American Chemical Society 20070523

• New mutation of the MPZ gene in a family with the Dejerine-Sottas disease phenotype.

  Muscle & nerve 20070501

• Dipeptidyl peptidase 8/9-like activity in human leukocytes.

  Journal of leukocyte biology 20070501

• Solute-inhibitor interactions in the plasmodial surface anion channel reveal complexities in the transport process.

  Molecular pharmacology 20070501

• Editing modifies the GABA(A) receptor subunit alpha3.

  RNA (New York, N.Y.) 20070501

• Biosynthesis of tiglic, ethacrylic, and 2-methylbutyric acids in a carabid beetle, Pterostichus (Hypherpes) californicus.

  Journal of chemical ecology 20070501

• Localization and expression of substance P in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations.

  Brain research 20070427

• A simple method for measuring long-range 1H-13C coupling constants in organic molecules.

  The Journal of organic chemistry 20070427

• The cold denatured state is compact but expands at low temperatures: hydrodynamic properties of the cold denatured state of the C-terminal domain of L9.

  Journal of molecular biology 20070420

• A comprehensive survey on isoleucine biosynthesis pathways in seven epidemic Leptospira interrogans reference strains of China.

  FEMS microbiology letters 20070401

• Transformation of the amyloidogenic peptide amylin(20-29) into its corresponding peptoid and retropeptoid: access to both an amyloid inhibitor and template for self-assembled supramolecular tapes.

  Bioorganic & medicinal chemistry letters 20070401

• Biosynthesis of hyperforin and adhyperforin from amino acid precursors in shoot cultures of Hypericum perforatum.

  Phytochemistry 20070401

• Radical induced fragmentation of amino acid esters using triphenylcorrole(CuIII) complexes.

  Journal of the American Society for Mass Spectrometry 20070401

• Influence of the Thr325Ile polymorphism on procarboxypeptidase U (thrombin-activable fibrinolysis inhibitor) activity-based assays.

  Journal of thrombosis and haemostasis : JTH 20070401

• Isoleucine, an essential amino acid, prevents liver metastases of colon cancer by antiangiogenesis.

  Cancer research 20070401

• Neuroimage findings in 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency.

  Pediatric neurology 20070401

• Presenilin 2 mutations alter cystatin C trafficking in mouse primary neurons.

  Neurobiology of aging 20070301

• Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum.

  Blood 20070301

• Ile-phe dipeptide self-assembly: clues to amyloid formation.

  Biophysical journal 20070301

• Glutaric aciduria type 1: clinical, biochemical and molecular findings in patients from Israel.

  European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20070301

• Substitution of critical isoleucines in the KH domains of Drosophila fragile X protein results in partial loss-of-function phenotypes.

  Genetics 20070301

• Isoleucine infusion during 'simulated' upper gastrointestinal bleeding improves liver and muscle protein synthesis in cirrhotic patients.

  Hepatology (Baltimore, Md.) 20070301

• Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians.

  Drug and alcohol dependence 20070223

• With targeted drugs, chronic myelogenous leukemia therapy may follow HIV's model.

  Journal of the National Cancer Institute 20070207

• The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer.

  Carcinogenesis 20070201

• Germline CHEK2 mutations and colorectal cancer risk: different effects of a missense and truncating mutations?

  European journal of human genetics : EJHG 20070201

• Characterization of a familial case with primary erythromelalgia from Taiwan.

  Journal of neurology 20070201

• Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20070201

• A model for agonism and antagonism in an ancient and ubiquitous cAMP-binding domain.

  The Journal of biological chemistry 20070105

• Altered -3 substrate specificity of Escherichia coli signal peptidase 1 mutants as revealed by screening a combinatorial peptide library.

  The Journal of biological chemistry 20070105

• Abnormal regulatory interactions of I148T-CFTR and the epithelial Na+ channel in Xenopus oocytes.

  American journal of physiology. Cell physiology 20070101

• How to discriminate between leucine and isoleucine by low energy ESI-TRAP MSn.

  Journal of the American Society for Mass Spectrometry 20070101

• Chemical synthesis and crystallization of the dipeptide AcPheIleNH(2) in TTAB/heptane/octanol reversed micelles.

  Journal of colloid and interface science 20070101

• Role of the STK15 Phe31Ile polymorphism in renal cell carcinoma.

  Oncology reports 20070101

• Trigger finger as an initial manifestation of familial amyloid polyneuropathy in a patient with Ile107Val TTR.

  Internal medicine (Tokyo, Japan) 20070101

• The V118I mutation as a marker of advanced HIV infection and disease progression.

  Antiviral therapy 20070101

• A simple and selective method for the measurement of leucine and isoleucine from plasma using electrospray ionization tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• HSD17B10: a gene involved in cognitive function through metabolism of isoleucine and neuroactive steroids.

  Molecular genetics and metabolism 20070101

• Glutathione S-transferase P1 genotypes, genetic susceptibility and outcome of therapy in thai childhood acute lymphoblastic leukemia.

  Asian Pacific journal of cancer prevention : APJCP 20070101

• [Compliance of the diet restricted with leucine, isoleucine and valine in maple syrup urine disease (MSUD) children].

  Roczniki Panstwowego Zakladu Higieny 20070101

• Electrospray ionization ion trap multiple-stage mass spectrometric fragmentation pathways of leucine and isoleucine: an ab initio computational study.

  Rapid communications in mass spectrometry : RCM 20070101

• Propionic acidemia manifesting with low isoleucine generalized exfoliative dermatosis.

  Pediatric dermatology 20070101

• The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia.

  Neuromolecular medicine 20070101

• Jasmonates and its mimics differentially elicit systemic defence responses in Nicotiana attenuata.

  Journal of experimental botany 20070101

• Cysteine-scanning analysis of the nucleobase-ascorbate transporter signature motif in YgfO permease of Escherichia coli: Gln-324 and Asn-325 are essential, and Ile-329-Val-339 form an alpha-helix.

  The Journal of biological chemistry 20061229

• Calmodulin-androgen receptor (AR) interaction: calcium-dependent, calpain-mediated breakdown of AR in LNCaP prostate cancer cells.

  Cancer research 20061215

• Inborn errors of isoleucine degradation: a review.

  Molecular genetics and metabolism 20061201

• Generalized epidermolytic hyperkeratosis in two unrelated children from parents with localized linear form, and prenatal diagnosis.

  The Journal of investigative dermatology 20061201

• Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.

  Lung cancer (Amsterdam, Netherlands) 20061201

• Two Arabidopsis threonine aldolases are nonredundant and compete with threonine deaminase for a common substrate pool.

  The Plant cell 20061201

• V180I mutation of the prion protein gene associated with atypical PrPSc glycosylation.

  Neuroscience letters 20061120

• Compound heterozygous mutations P336L and I1660V in the human cardiac sodium channel associated with the Brugada syndrome.

  Circulation 20061107

• Selective blockade of glycoprotein VI clustering on collagen helices.

  The Journal of biological chemistry 20061103

• Self-association of isolated large cytoplasmic domain of plasma membrane H+ -ATPase from Saccharomyces cerevisiae: role of the phosphorylation domain in a general dimeric model for P-ATPases.

  Biochimica et biophysica acta 20061101

• Silencing threonine deaminase and JAR4 in Nicotiana attenuata impairs jasmonic acid-isoleucine-mediated defenses against Manduca sexta.

  The Plant cell 20061101

• Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia.

  Archives of neurology 20061101

• Functional polymorphism 57Val>Ile of aurora kinase A associated with increased risk of gastric cancer progression.

  Cancer letters 20061028

• Participation of the Lys313-Ile333 sequence of the purinergic P2X4 receptor in agonist binding and transduction of signals to the channel gate.

  The Journal of biological chemistry 20061027

• Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra.

  Neuroscience letters 20061016

• A single amino acid mutation attenuates rundown of voltage-gated calcium channels.

  FEBS letters 20061016

• Both experimental and theoretical investigations of solid-state 17O NMR for L-valine and L-isoleucine.

  Solid state nuclear magnetic resonance 20061001

• Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity.

  The Journal of biological chemistry 20060929

• Atomic structure of plant glutamine synthetase: a key enzyme for plant productivity.

  The Journal of biological chemistry 20060929

• ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B).

  Neurology 20060926

• Characterization of the acyl substrate binding pocket of acetyl-CoA synthetase.

  Biochemistry 20060926

• Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease.

  Journal of the neurological sciences 20060925

• Enantioselectivity of vesicle-forming chiral surfactants in capillary electrophoresis. Role of the surfactant headgroup structure.

  Journal of chromatography. A 20060922

• Glucocerebrosidase mutations are an important risk factor for Lewy body disorders.

  Neurology 20060912

• Late-onset metachromatic leukodystrophy: genotype strongly influences phenotype.

  Neurology 20060912

• Context-dependent effects on the hydrophilicity/hydrophobicity of side-chains during reversed-phase high-performance liquid chromatography: Implications for prediction of peptide retention behaviour.

  Journal of chromatography. A 20060901

• Dietary branched-chain amino acid valine, isoleucine and leucine requirements of fingerling Indian major carp, Cirrhinus mrigala (Hamilton).

  The British journal of nutrition 20060901

• Is a novel I214M substitution in the NEFL gene a cause of Charcot-Marie-Tooth disease? Functional analysis using cell culture models.

  Journal of the peripheral nervous system : JPNS 20060901

• In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans.

  Antimicrobial agents and chemotherapy 20060901

• Clinical phenotypes of a large Chinese multigenerational kindred with autosomal dominant familial ALS due to Ile149Thr SOD1 gene mutation.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20060901

• A simple and reliable approach to docking protein-protein complexes from very sparse NOE-derived intermolecular distance restraints.

  Journal of biomolecular NMR 20060901

• The angiotensin converting enzyme I/D polymorphism in long distance runners.

  The Journal of sports medicine and physical fitness 20060901

• Biochemical characterization of vitreous and cardiac amyloid in Ile84Ser transthyretin amyloidosis.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20060901

• [A case of beta-ketothiolase deficiency].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20060901

• Asymmetric total syntheses of marine cyclic depsipeptide halipeptins A-D.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20060825

• Characterization of the stomatin domain involved in homo-oligomerization and lipid raft association.

  The Journal of biological chemistry 20060818

• A novel Val734Ile variant in the ABCC9 gene associated with myocardial infarction.

  Clinica chimica acta; international journal of clinical chemistry 20060801

• Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons.

  Molecular pharmacology 20060801

• Newborn screening may fail to identify intermediate forms of maple syrup urine disease.

  Journal of inherited metabolic disease 20060801

• Global effects of homocysteine on transcription in Escherichia coli: induction of the gene for the major cold-shock protein, CspA.

  Microbiology (Reading, England) 20060801

• Increasing dietary crude protein does not increase the essential amino acid requirements of kittens.

  Journal of animal physiology and animal nutrition 20060801

• TRAIL enhances efficacy of radiotherapy in a p53 mutant, Bcl-2 overexpressing lymphoid malignancy.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20060801

• [Expression of isoleucine zipper modified soluble CD40L in Pichia pastoris].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20060801

• Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk.

  Journal of the National Cancer Institute 20060719

• Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells.

  Journal of cell science 20060715

• Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons.

  Journal of neurophysiology 20060701

• Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats.

  Molecular pharmacology 20060701

• Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling.

  Journal of immunology (Baltimore, Md. : 1950) 20060701

• Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation.

  The Journal of biological chemistry 20060630

• Efficient method for selective introduction of substituents as C5 of isoleucine and other alpha-amino acids.

  Organic letters 20060622

• Structural basis for substrate recognition by the editing domain of isoleucyl-tRNA synthetase.

  Journal of molecular biology 20060616

• Polymorphic amino acids at codons 9 and 37 of HLA-DQB1 alleles may confer susceptibility to cervical cancer among Chinese women.

  International journal of cancer 20060615

• Use of Intralipid for kinetic analysis of HDL apoC-III: evidence for a homogeneous kinetic pool of apoC-III in plasma.

  Journal of lipid research 20060601

• Stereoselective incorporation of isoleucine into Cypridina luciferin in Cypridina hilgendorfii (Vargula hilgendorfii).

  Bioscience, biotechnology, and biochemistry 20060601

• Rational design of a reversible pH-responsive switch for peptide self-assembly.

  Journal of the American Chemical Society 20060531

• Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060517

• Asymmetric, anti-selective scandium-catalyzed Sakurai additions to glyoxyamide. Applications to the syntheses of N-boc D-alloisoleucine and D-isoleucine.

  Organic letters 20060511

• Targeted suppression of an amyloidogenic transthyretin with antisense oligonucleotides.

  Muscle & nerve 20060501

• Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation.

  Movement disorders : official journal of the Movement Disorder Society 20060501

• A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans.

  Nature neuroscience 20060501

• Domino liver transplantation in maple syrup urine disease.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20060501

• [Preparation and identification of soluble trimeric CD40-isoleucine zipper fusion protein].

  Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20060501

• Transthyretin V122I in African Americans with congestive heart failure.

  Journal of the American College of Cardiology 20060418

• Structural definition of the H-2Kd peptide-binding motif.

  The Journal of biological chemistry 20060414

• Expanding the mutational spectrum in TGFBI-linked corneal dystrophies: Identification of a novel and unusual mutation (Val113Ile) in a family with granular dystrophy.

  Molecular vision 20060410

• [Dyskeratosis congenita in a 40-year-old patient].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20060401

• Albumin and amino acids upregulate the expression of human beta-defensin 1.

  Molecular immunology 20060401

• A novel small reporter gene and HIV-1 fitness assay.

  Journal of virological methods 20060401

• Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399ile are hypo-responsive to Porphyromonas gingivalis.

  Genes and immunity 20060401

• Estimation of nutrient requirements using broken-line regression analysis.

  Journal of animal science 20060401

• [Acrodermatitis enteropathica-like syndrome secondary to branched-chain amino acid deficiency during treatment of maple syrup urine disease].

  Annales de dermatologie et de venereologie 20060401

• Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining.

  The Journal of biological chemistry 20060331

• Activity of human dihydrolipoamide dehydrogenase is largely reduced by mutation at isoleucine-51 to alanine.

  Journal of biochemistry and molecular biology 20060331

• Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles.

  The Journal of biological chemistry 20060324

• Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies.

  The Journal of biological chemistry 20060317

• Endothelin-3-converting enzyme activity of the KEL1 and KEL6 phenotypes of the Kell blood group system.

  The Journal of biological chemistry 20060317

• Sporadic amyotrophic lateral sclerosis and breast cancer: Hyaline conglomerate inclusions lead to identification of SOD1 mutation.

  Journal of the neurological sciences 20060315

• Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination.

  The Biochemical journal 20060301

• Enhancement of binding activity of soluble human CD40 to CD40 ligand through incorporation of an isoleucine zipper motif.

  Acta pharmacologica Sinica 20060301

• The aspartic acid metabolic pathway, an exciting and essential pathway in plants.

  Amino acids 20060301

• Roles of type 10 17beta-hydroxysteroid dehydrogenase in intracrinology and metabolism of isoleucine and fatty acids.

  Endocrine, metabolic & immune disorders drug targets 20060301

• Production and use of trimeric isoleucine zipper fusion proteins to study surface receptor ligand interactions.

  Current protocols in protein science 20060301

• Roles of the heme distal residues of FixL in O2 sensing: a single convergent structure of the heme moiety is relevant to the downregulation of kinase activity.

  Biochemistry 20060227

• Plasma arginine correlations in trauma and sepsis.

  Amino acids 20060201

• Cholesteryl ester transfer protein (CETP) polymorphism modifies the Alzheimer's disease risk associated with APOE epsilon4 allele.

  Journal of neurology 20060201

• Lack of carcinogenicity of L-isoleucine in F344/DuCrj rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060201

• Short/branched-chain acyl-CoA dehydrogenase deficiency due to an IVS3+3A>G mutation that causes exon skipping.

  Human genetics 20060201

• Maintenance threonine requirement and efficiency of its use for accretion of whole-body threonine and protein in Atlantic salmon (Salmo salar L.) fry.

  The British journal of nutrition 20060201

• Atypical phenotype in a boy with a maple syrup urine disease.

  Journal of inherited metabolic disease 20060201

• Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.

  The Journal of biological chemistry 20060127

• Roles of N-terminal pyroglutamate in maintaining structural integrity and pKa values of catalytic histidine residues in bullfrog ribonuclease 3.

  Journal of molecular biology 20060120

• 4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent.

  Bioorganic & medicinal chemistry letters 20060115

• I405V polymorphism of the cholesteryl ester transfer protein (CETP) gene in young and very old people.

  Archives of gerontology and geriatrics 20060101

• Stereoselective incorporation of an unsaturated isoleucine analogue into a protein expressed in E. coli.

  Chembiochem : a European journal of chemical biology 20060101

• Production and characterization of murine models of classic and intermediate maple syrup urine disease.

  BMC medical genetics 20060101

• Handedness control of peptide helices by amino acid side-chain chirality: Ile/aIle peptides.

  Biopolymers 20060101

• Dipeptidyl peptidases and inflammatory bowel disease.

  Advances in experimental medicine and biology 20060101

• [The effect of some amino acids on the growth and biosynthesis of ergot alkaloids and quinocitrinins in the fungus Penicillium citrinum Thom 1910].

  Mikrobiologiia 20060101

• [Components of fermentation medium regulate bacteriocin synthesis by the recombinant strain Lactococcus lactis subsp. lactis F-116].

  Mikrobiologiia 20060101

• Autopsy-proven Creutzfeldt-Jakob disease with a codon 180 mutation showing dissociation between diffusion-weighted magnetic resonance imaging and single-photon emission computed tomography findings: Is this a suggestive finding in long survival?

  European neurology 20060101

• Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7).

  The Journal of biological chemistry 20051230

• Role of the transmembrane domain of FXYD7 in structural and functional interactions with Na,K-ATPase.

  The Journal of biological chemistry 20051230

• Transgenic potato expressing Abeta reduce Abeta burden in Alzheimer's disease mouse model.

  FEBS letters 20051219

• Hypotaurocyamine kinase evolved from a gene for arginine kinase.

  FEBS letters 20051219

• Identification of six novel allosteric effectors of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase isoforms. Physiological context sets the specificity.

  The Journal of biological chemistry 20051216

• Quantitative 13C and 2H NMR relaxation studies of the 723-residue enzyme malate synthase G reveal a dynamic binding interface.

  Biochemistry 20051213

• Reply: a bias in genotyping of the ERBB2 (HER2) Ile655Val variant.

  Carcinogenesis 20051201

• Pharmacological characterization of human and murine neuropeptide s receptor variants.

  The Journal of pharmacology and experimental therapeutics 20051201

• Tobacco smoking, GSTP1 polymorphism, and bladder carcinoma.

  Cancer 20051201

• Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex.

  Nature structural & molecular biology 20051201

• Anatomy of a trans-cis peptide transition during least-squares refinement of rubrerythrin.

  Acta crystallographica. Section D, Biological crystallography 20051201

• Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051201

• Fe3+-hydroxide ligation in the superoxide reductase from Desulfoarculus baarsii is associated with pH dependent spectral changes.

  Journal of the American Chemical Society 20051130

• Sensitivity of the Drosophila para sodium channel to DDT is not lowered by the super-kdr mutation M918T on the IIS4-S5 linker that profoundly reduces sensitivity to permethrin and deltamethrin.

  FEBS letters 20051121

• Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorder.

  The Journal of biological chemistry 20051118

• Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin.

  The Journal of biological chemistry 20051104

• A stability pattern of protein hydrophobic mutations that reflects evolutionary structural optimization.

  Biophysical journal 20051101

• The catalytic copper of peptidylglycine alpha-hydroxylating monooxygenase also plays a critical structural role.

  Biophysical journal 20051101

• Enhancement of lignan biosynthesis in suspension cultures of Linum nodiflorum by coronalon, indanoyl-isoleucine and methyl jasmonate.

  Planta 20051101

• Size, constant sequences, and optimal selection.

  RNA (New York, N.Y.) 20051101

• Isoleucine requirement of 80- to 120-kilogram barrows fed corn-soybean meal or corn-blood cell diets.

  Journal of animal science 20051101

• CD14 and TLR4 gene polymorphisms in adult periodontitis.

  Journal of dental research 20051101

• Substitution of isoleucine L177 by histidine affects the pigment composition and properties of the reaction center of the purple bacterium Rhodobacter sphaeroides.

  Biochemistry. Biokhimiia 20051101

• [Analysis of the coding region for signal peptide-containing proteins in Pseudomonas syringae pv. tomato genome].

  Yi chuan = Hereditas 20051101

• Determinants of substrate specificity in omega-aminotransferases.

  The Journal of biological chemistry 20051028

• Distinction of Leu and Ile Using a Ruthenium(II) complex by MALDI-LIFT-TOF/TOF-MS analysis.

  Analytical chemistry 20051015

• FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling.

  Human molecular genetics 20051001

• Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma.

  Human molecular genetics 20051001

• Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.

  Diabetes 20051001

• Theoretical study of the gas-phase structures of sodiated and cesiated leucine and isoleucine: zwitterionic structure disfavored in kinetic method experiments.

  Journal of mass spectrometry : JMS 20051001

• An 11-day-old boy with lethargy, poor feeding, vomiting. Maple syrup urine disease.

  Pediatric annals 20051001

• Coded amino acids in gas phase: the shape of isoleucine.

  Journal of the American Chemical Society 20050921

• Effects of the sequence and size of non-polar residues on self-assembly of amphiphilic peptides.

  International journal of biological macromolecules 20050915

• Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis.

  Archives of internal medicine 20050912

• A bias in genotyping the ERBB2 (HER2) Ile655Val variant.

  Carcinogenesis 20050901

• An active transport system in the blood-brain barrier may reduce levodopa availability.

  Experimental neurology 20050901

• 164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study.

  Pharmacogenetics and genomics 20050901

• Full-capillary sample stacking/sweeping-MEKC for the separation of naphthalene-2,3-dicarboxaldehyde-derivatized tryptophan and isoleucine.

  Electrophoresis 20050901

• 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency: an X-linked inborn error of isoleucine metabolism that may mimic a mitochondrial disease.

  Pediatric research 20050901

• Association study of Glutathione S-transferase P1 (GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations.

  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20050901

• Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis.

  Nature 20050825

• The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity.

  FEBS letters 20050815

• Mutagenesis of Ala290, which modulates substrate subsite affinity at the catalytic interface of dimeric ThMA.

  Biochimica et biophysica acta 20050810

• Kinetic evidence for interaction of human immunodeficiency virus type 1 reverse transcriptase with the 3'-OH of the incoming dTTP substrate.

  Biochemistry 20050809

• The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry.

  The Journal of biological chemistry 20050805

• Formation of an antiparallel, intermolecular coiled coil is associated with in vivo dimerization of osmosensor and osmoprotectant transporter ProP in Escherichia coli.

  Biochemistry 20050802

• Biphasic kinetics of the colchicine-tubulin interaction: role of amino acids surrounding the A ring of bound colchicine molecule.

  Biochemistry 20050802

• A new mutation (Thr106Ile) of the GTP cyclohydrolase 1 gene associated with DYT5 dystonia (Segawa disease).

  Movement disorders : official journal of the Movement Disorder Society 20050801

• A single residue in the S6 transmembrane domain governs the differential flecainide sensitivity of voltage-gated potassium channels.

  Molecular pharmacology 20050801

• Impact of the Asp299Gly polymorphism in the toll-like receptor 4 (tlr-4) gene on disease course of multiple sclerosis.

  Journal of neuroimmunology 20050801

• Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder.

  Pediatric research 20050801

• T315I-mutated Bcr-Abl in chronic myeloid leukemia and imatinib: insights from a computational study.

  Molecular cancer therapeutics 20050801

• PS1 knockin mice with the Japanese I213T mutation: effects on exploratory activity, motor coordination, and spatial learning.

  Behavioural brain research 20050730

• Critical hydrophobic interactions between phosphorylation and actuator domains of Ca2+-ATPase for hydrolysis of phosphorylated intermediate.

  The Journal of biological chemistry 20050715

• A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation.

  Biochemical and biophysical research communications 20050715

• Novel compound heterozygous mutations in the PANK2 gene in a Chinese patient with atypical pantothenate kinase-associated neurodegeneration.

  Movement disorders : official journal of the Movement Disorder Society 20050701

• The role of the periplasmic loop residue glutamine 65 for MscL mechanosensitivity.

  European biophysics journal : EBJ 20050701

• Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency.

  The Journal of biological chemistry 20050701

• Short communication: Amino acids antagonistic to the amino acids inhibitory for growth rate of mixed ruminal bacteria.

  Journal of dairy science 20050701

• TAFI gene haplotypes, TAFI plasma levels and future risk of coronary heart disease: the PRIME Study.

  Journal of thrombosis and haemostasis : JTH 20050701

• Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase.

  Structure (London, England : 1993) 20050701

• Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients.

  Neuroreport 20050621

• Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study.

  Journal of molecular biology 20050617

• Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors.

  Archives of biochemistry and biophysics 20050615

• Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha.

  The Journal of biological chemistry 20050610

• A systematic mutagenesis study of Ile-282 in transmembrane segment M4 of the plasma membrane H+-ATPase.

  The Journal of biological chemistry 20050610

• Probing side-chain dynamics in high molecular weight proteins by deuterium NMR spin relaxation: an application to an 82-kDa enzyme.

  Journal of the American Chemical Society 20050608

• Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227.

  The Journal of biological chemistry 20050603

• Branched-chain amino acids improve glucose metabolism in rats with liver cirrhosis.

  American journal of physiology. Gastrointestinal and liver physiology 20050601

• Functional analysis of the human variants of breast cancer resistance protein: I206L, N590Y, and D620N.

  Drug metabolism and disposition: the biological fate of chemicals 20050601

• Homology modeling based solution structure of Hoxc8-DNA complex: role of context bases outside TAAT stretch.

  Journal of biomolecular structure & dynamics 20050601

• Identification of a new HLA-DRB1 allele, HLA-DRB1*1212, and confirmation of HLA-B*1586*.

  Tissue antigens 20050601

• Bacillus subtilis ilvB operon: an intersection of global regulons.

  Molecular microbiology 20050601

• Elaborate transcription regulation of the Bacillus subtilis ilv-leu operon involved in the biosynthesis of branched-chain amino acids through global regulators of CcpA, CodY and TnrA.

  Molecular microbiology 20050601

• Role of isoleucine residues 182 and 183 in thrombin-activatable fibrinolysis inhibitor.

  Journal of thrombosis and haemostasis : JTH 20050601

• A prospective evaluation of the transthyretin Ile122 allele frequency in an African-American population.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20050601

• A more complex isoleucine aptamer with a cognate triplet.

  The Journal of biological chemistry 20050520

• Ligand-free and -bound structures of the binding protein (LivJ) of the Escherichia coli ABC leucine/isoleucine/valine transport system: trajectory and dynamics of the interdomain rotation and ligand specificity.

  Biochemistry 20050503

• Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection.

  The American journal of gastroenterology 20050501

• Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.

  The Journal of biological chemistry 20050422

• Relationship of ethylene biosynthesis to volatile production, related enzymes, and precursor availability in apple peel and flesh tissues.

  Journal of agricultural and food chemistry 20050420

• Targeting the gatekeeper residue in phosphoinositide 3-kinases.

  Bioorganic & medicinal chemistry 20050415

• Analysis of plasma amino acids by HPLC with photodiode array and fluorescence detection.

  Clinica chimica acta; international journal of clinical chemistry 20050401

• Diagnosis of MSUD by newborn screening allows early intervention without extraneous detoxification.

  Molecular genetics and metabolism 20050401

• One pot conjugation of the polypeptides directed by phosphorus oxychloride.

  The journal of peptide research : official journal of the American Peptide Society 20050401

• Ile115Leu mutation in the SRS1 region of an insect cytochrome P450 (CYP6B1) compromises substrate turnover via changes in a predicted product release channel.

  Protein engineering, design & selection : PEDS 20050401

• A mathematical model for the branched chain amino acid biosynthetic pathways of Escherichia coli K12.

  The Journal of biological chemistry 20050325

• A chemosensor array for the colorimetric identification of 20 natural amino acids.

  Journal of the American Chemical Society 20050323

• Interaction between the catalytic site and the A-M3 linker stabilizes E2/E2P conformational states of Na+,K+-ATPase.

  The Journal of biological chemistry 20050318

• Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity.

  Biochemistry 20050315

• Utilizing the split-ubiquitin membrane yeast two-hybrid system to identify protein-protein interactions of integral membrane proteins.

  Science's STKE : signal transduction knowledge environment 20050315

• Effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes.

  European journal of pharmacology 20050314

• Dimeric transthyretin variant assembles into spherical neurotoxins.

  Biochemistry 20050308

• Phosphorylation by MAPK regulates simian immunodeficiency virus Vpx protein nuclear import and virus infectivity.

  The Journal of biological chemistry 20050304

• Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20050301

• The rare ERBB2 variant Ile654Val is associated with an increased familial breast cancer risk.

  Carcinogenesis 20050301

• 2-ethylhydracrylic aciduria in short/branched-chain acyl-CoA dehydrogenase deficiency: application to diagnosis and implications for the R-pathway of isoleucine oxidation.

  Clinical chemistry 20050301

• [Study of enantiomeric separation of DL-amino acids on L-isoleucine-type chiral-ligand-exchange stationary phase].

  Se pu = Chinese journal of chromatography 20050301

• The identification of residues that control signal peptidase cleavage fidelity and substrate specificity.

  The Journal of biological chemistry 20050225

• Quantum chemical evaluation of protein control over heme ligation: CO/O2 discrimination in myoglobin.

  The journal of physical chemistry. B 20050224

• A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+.

  The Journal of biological chemistry 20050211

• T280M and V249I polymorphisms of fractalkine receptor CX3CR1 and ischemic cerebrovascular disease.

  Neuroscience letters 20050210

• Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes.

  The Journal of biological chemistry 20050204

• X-linked Charcot-Marie-Tooth disease: phenotypic expression of a novel mutation Ile127Ser in the GJB1 (connexin 32) gene.

  Muscle & nerve 20050201

• Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding.

  Molecular pharmacology 20050201

• The correlation between monocyte chemoattractant protein-1 and the arthritis of systemic lupus erythematosus among Chinese.

  Archives of dermatological research 20050201

• Ile118Val genetic polymorphism of CYP3A4 and its effects on lipid-lowering efficacy of simvastatin in Chinese hyperlipidemic patients.

  European journal of clinical pharmacology 20050201

• Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies.

  Haematologica 20050201

• The addition of fenugreek extract (Trigonella foenum-graecum) to glucose feeding increases muscle glycogen resynthesis after exercise.

  Amino acids 20050201

• [I164T polymorphism of adiponectin gene in diabetes].

  Nihon rinsho. Japanese journal of clinical medicine 20050201

• A new mutation in the yeast aspartate kinase induces threonine accumulation in a temperature-regulated way.

  Yeast (Chichester, England) 20050130

• Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase.

  Archives of biochemistry and biophysics 20050115

• Reversible assembly of helical filaments by de novo designed minimalist peptides.

  Biopolymers 20050101

• Double heterozygosity for a novel missense mutation of Ile304 to Asn in addition to the missense mutation His280 to Pro in the integrin beta3 gene as a cause of the absence of platelet alphaIIbbeta3 in Glanzmann's thrombasthenia.

  Journal of thrombosis and haemostasis : JTH 20050101

• The use of trimeric isoleucine-zipper fusion proteins to study surface-receptor-ligand interactions in natural killer cells.

  Journal of immunological methods 20050101

• Colonic adenomas do not cosegregate with the I1307K APC missense mutation in an Israeli non-Ashkenazi family.

  Digestive diseases and sciences 20050101

• 6-Substituted indanoyl isoleucine conjugate induces tobacco plant responses in secondary metabolites.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101

• The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana.

  Plant molecular biology 20050101

• Multiple functions of type 10 17beta-hydroxysteroid dehydrogenase.

  Trends in endocrinology and metabolism: TEM 20050101

• Evaluation of the mechanisms involved in leucine-induced oxidative damage in cerebral cortex of young rats.

  Free radical research 20050101

• A new protein substitute for adolescents and adults with maple syrup urine disease (MSUD).

  Journal of inherited metabolic disease 20050101

• Effect of individual amino acids and glucose on activation and germination of Rhizopus oligosporus sporangiospores in tempe starter.

  Journal of applied microbiology 20050101

• Identification of amino acid residues that direct differential ligand selectivity of mammalian and nonmammalian V1a type receptors for arginine vasopressin and vasotocin. Insights into molecular coevolution of V1a type receptors and their ligands.

  The Journal of biological chemistry 20041224

• Substrate interaction at an iron-sulfur face of the FeMo-cofactor during nitrogenase catalysis.

  The Journal of biological chemistry 20041217

• Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.

  Biochemistry 20041214

• Meteoritic C alpha-methylated alpha-amino acids and the homochirality of life: searching for a link.

  Angewandte Chemie (International ed. in English) 20041210

• Structural scaffold of 18-crown-6 tetracarboxylic acid for optical resolution of chiral amino acid: X-ray crystal analyses and energy calculations of complexes of D- and L-isomers of tyrosine, isoleucine, methionine and phenylglycine.

  Organic & biomolecular chemistry 20041207

• Analysis of the third transmembrane domain of the human type 1 angiotensin II receptor by cysteine scanning mutagenesis.

  The Journal of biological chemistry 20041203

• Stereospecific, enantioselective allylation of alpha-hydrazono esters by using allyltrichlorosilanes with BINAP dioxides as neutral-coordinate organocatalysts.

  Angewandte Chemie (International ed. in English) 20041203

• Mitochondrial beta-oxidation in Aspergillus nidulans.

  Molecular microbiology 20041201

• Isoleucine needs of thirty- to forty-day-old female chickens: immunity.

  Poultry science 20041201

• Isoleucine needs of thirty- to forty-two-day-old female chickens: growth and carcass responses.

  Poultry science 20041201

• The effects of amino acid replacements of glycine 20 on conformational stability and catalysis of staphylococcal nuclease.

  Biochimie 20041201

• Steric effects of isoleucine 107 on heme reorientation reaction in human myoglobin.

  Biochemical and biophysical research communications 20041119

• Identification of residues Asn89, Ile90, and Val107 of the factor IXa second epidermal growth factor domain that are essential for the assembly of the factor X-activating complex on activated platelets.

  The Journal of biological chemistry 20041105

• Active site engineering of the epoxide hydrolase from Agrobacterium radiobacter AD1 to enhance aerobic mineralization of cis-1,2-dichloroethylene in cells expressing an evolved toluene ortho-monooxygenase.

  The Journal of biological chemistry 20041105

• Isoleucine 69 and valine 325 form a specificity pocket in human muscle creatine kinase.

  Biochemistry 20041102

• Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.

  Carcinogenesis 20041101

• High prevalence of V37I genetic variant in the connexin-26 (GJB2) gene among non-syndromic hearing-impaired and control Thai individuals.

  Clinical genetics 20041101

• Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer.

  Cancer genetics and cytogenetics 20041101

• Met688Ile and Leu390Phe of the MSH2 gene are not functional mutations, but polymorphisms in Japanese individuals.

  Cancer genetics and cytogenetics 20041101

• Growth promotion of mycelia of the Matsutake mushroom Tricholoma matsutake by D-isoleucine.

  Bioscience, biotechnology, and biochemistry 20041101

• The T341C (Ile114Thr) polymorphism of N-acetyltransferase 2 yields slow acetylator phenotype by enhanced protein degradation.

  Pharmacogenetics 20041101

• The influence of the amino acid substitution I98K on the catalytic activity of baboon cytochrome P450 side-chain cleavage (CYP11A1).

  Endocrine research 20041101

• Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme.

  The Journal of biological chemistry 20041022

• A crystallographic titration of the dipeptide L-isoleucyl-L-isoleucine.

  Acta crystallographica. Section B, Structural science 20041001

• An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation.

  Journal of immunology (Baltimore, Md. : 1950) 20041001

• RNA editing of a human potassium channel modifies its inactivation.

  Nature structural & molecular biology 20041001

• Prevalence of the GJB2 mutations and the del(GJB6-D13S1830) mutation in Brazilian patients with deafness.

  Hearing research 20041001

• Novel mutation in the SPG3A gene in an African American family with an early onset of hereditary spastic paraplegia.

  Archives of neurology 20041001

• Molecular characterization and inheritance of resistance to ACCase-inhibiting herbicides in Lolium rigidum.

  Pest management science 20041001

• Clinical and biochemical manifestations and molecular characterization of the mutation HPRT Jerusalem.

  Nucleosides, nucleotides & nucleic acids 20041001

• The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.

  Biochemistry 20040928

• Treatment with leucine stimulates the production of hepatocyte growth factor in vivo.

  Biochemical and biophysical research communications 20040924

• Increased cytotoxicity of soluble Fas ligand by fusing isoleucine zipper motif.

  Biochemical and biophysical research communications 20040910

• Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat.

  American journal of physiology. Endocrinology and metabolism 20040901

• Central core disease mutations R4892W, I4897T and G4898E in the ryanodine receptor isoform 1 reduce the Ca2+ sensitivity and amplitude of Ca2+-dependent Ca2+ release.

  The Biochemical journal 20040901

• Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).

  The international journal of biochemistry & cell biology 20040901

• Buried hydrophobic side-chains essential for the folding of the parallel beta-helix domains of the P22 tailspike.

  Protein science : a publication of the Protein Society 20040901

• Synergistic effects of mupirocin and an isoflavanone isolated from Erythrina variegata on growth and recovery of methicillin-resistant Staphylococcus aureus.

  International journal of antimicrobial agents 20040901

• Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro.

  The European journal of neuroscience 20040901

• Effect of plasma insulin and branched-chain amino acids on skeletal muscle protein synthesis in fasted lambs.

  The British journal of nutrition 20040901

• Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA.

  The Journal of biological chemistry 20040820

• Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs.

  The Journal of biological chemistry 20040806

• Structural basis for catalytic differences between alpha class human glutathione transferases hGSTA1-1 and hGSTA2-2 for glutathione conjugation of environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide.

  Biochemistry 20040803

• Recognition of sphingomyelin by lysenin and lysenin-related proteins.

  Biochemistry 20040803

• Different conformational changes within the F-helix occur during serpin folding, polymerization, and proteinase inhibition.

  Biochemistry 20040803

• The oxylipin signal jasmonic acid is activated by an enzyme that conjugates it to isoleucine in Arabidopsis.

  The Plant cell 20040801

• A novel mutation (Thr116Ile) in the presenilin 1 gene in a patient with early-onset Alzheimer's disease.

  European journal of neurology 20040801

• Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo.

  Pharmacogenetics 20040801

• Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.

  The Journal of clinical endocrinology and metabolism 20040801

• The effect of sugar, amino acid, metal ion, and NaCl on model Maillard reaction under pH control.

  Amino acids 20040801

• Isoleucine requirements and ratios in starting (7 to 11 kg) pigs.

  Journal of animal science 20040801

• Utilization of spray-dried blood cells and crystalline isoleucine in nursery pig diets.

  Journal of animal science 20040801

• Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity.

  Chemistry & biology 20040801

• Anionic copper complex fragmentations from enkephalins under low-energy collision-induced dissociation in an ion trap mass spectrometer.

  Journal of mass spectrometry : JMS 20040801

• Response to lysine intake in composition of body weight gain and efficiency of lysine utilization of growing male chickens from two genotypes.

  Poultry science 20040801

• Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity.

  The Journal of biological chemistry 20040716

• A conserved motif for the transport of G protein-coupled receptors from the endoplasmic reticulum to the cell surface.

  The Journal of biological chemistry 20040716

• Direct detection of phospholamban and sarcoplasmic reticulum Ca-ATPase interaction in membranes using fluorescence resonance energy transfer.

  Biochemistry 20040713

• Alternative translations of a single RNA message: an identity switch of (2S,3R)-4,4,4-trifluorovaline between valine and isoleucine codons.

  Angewandte Chemie (International ed. in English) 20040712

• Insight into the mechanism of action of neuroactive steroids.

  Molecular pharmacology 20040701

• A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians.

  Diabetes 20040701

• Activation of the Bacillus subtilis global regulator CodY by direct interaction with branched-chain amino acids.

  Molecular microbiology 20040701

• Intracellular effectors regulating the activity of the Lactococcus lactis CodY pleiotropic transcription regulator.

  Molecular microbiology 20040701

• The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain.

  Obesity research 20040701

• alpha-Aminoallylation of aldehydes with ammonia: stereoselective synthesis of homoallylic primary amines.

  Journal of the American Chemical Society 20040616

• Cysteine-scanning mutagenesis and thiol modification of the Rickettsia prowazekii ATP/ADP translocase: evidence that transmembrane regions I and II, but not III, are structural components of the aqueous translocation channel.

  Biochemistry 20040608

• Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.

  Acta crystallographica. Section D, Biological crystallography 20040601

• A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.

  Diabetes 20040601

• Novel CLCN1 mutations in Taiwanese patients with myotonia congenita.

  Journal of neurology 20040601

• [Analysis of the glutathione S-transferase P1 gene Ile105Val polymorphism in the patients with sporadic motor neuron disease from Russia].

  Genetika 20040601

• Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta).

  Biochemistry 20040518

• Enhanced adhesive capacities of the naturally occurring Ile249-Met280 variant of the chemokine receptor CX3CR1.

  The Journal of biological chemistry 20040507

• Chirality determination of unusual amino acids using precolumn derivatization and liquid chromatography-electrospray ionization mass spectrometry.

  Journal of chromatography. A 20040507

• Structure and solvation of melittin in 1,1,1,3,3,3-hexafluoro-2-propanol/water.

  Biophysical journal 20040501

• Quantitative proteomics of the human malaria parasite Plasmodium falciparum and its application to studies of development and inhibition.

  Molecular microbiology 20040501

• L-Isoleucyl-L-phenylalanine dihydrate.

  Acta crystallographica. Section C, Crystal structure communications 20040501

• Isoleucine requirement for late-finishing (87 to 100 kg) pigs.

  Journal of animal science 20040501

• Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.

  The European journal of neuroscience 20040501

• A site-directed mutagenesis interrogation of the carboxy-terminal end of Arabidopsis thaliana threonine dehydratase/deaminase reveals a synergistic interaction between two effector-binding sites and contributes to the development of a novel selectable marker.

  Plant molecular biology 20040501

• A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles.

  The Journal of biological chemistry 20040430

• A role for dNTP binding of human immunodeficiency virus type 1 reverse transcriptase in viral mutagenesis.

  Biochemistry 20040420

• Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement.

  The Biochemical journal 20040415

• The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis.

  Journal of the American Chemical Society 20040414

• Coronalon: a powerful tool in plant stress physiology.

  FEBS letters 20040409

• Antigenic cross-reactivity and sequence homology between Actinobacillus actinomycetemcomitans GroEL protein and human fibronectin.

  Oral microbiology and immunology 20040401

• Amino acid residue ILE211 is essential for the enzymatic activity of human UDP-glucuronosyltransferase 1A10 (UGT1A10).

  Drug metabolism and disposition: the biological fate of chemicals 20040401

• Blood serum branched chain amino acids and tryptophan modifications in horses competing in long-distance rides of different length.

  Journal of animal physiology and animal nutrition 20040401

• Spastic diplegia and periventricular white matter abnormalities in 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency, a defect of isoleucine metabolism: differential diagnosis with hypoxic-ischemic brain diseases.

  Molecular genetics and metabolism 20040401

• A conditional marker gene allowing both positive and negative selection in plants.

  Nature biotechnology 20040401

• The role of methionine in ethylmalonic encephalopathy with petechiae.

  Archives of neurology 20040401

• Ubiquitin recognition by the human TSG101 protein.

  Molecular cell 20040326

• Motion of spin label side chains in cellular retinol-binding protein: correlation with structure and nearest-neighbor interactions in an antiparallel beta-sheet.

  Biochemistry 20040323

• The first enantioselective synthesis of the amino acid, (2S,3S,4R)-gamma-hydroxyisoleucine using a palladium(II) catalysed 3,3-sigmatropic rearrangement.

  Organic & biomolecular chemistry 20040321

• Thermodynamics of core hydrophobicity and packing in the hyperthermophile proteins Sac7d and Sso7d.

  Biochemistry 20040316

• The beta- and gamma-CH2 of B27-WT's Leu11 and Ile18 side chains play a direct role in calpain inhibition.

  Biochemistry 20040309

• Synthesis of (2S,3S)-3'-fluoroisoleucine.

  Organic & biomolecular chemistry 20040307

• Evaluation of the Escherichia coli threonine deaminase gene as a selectable marker for plant transformation.

  Planta 20040301

• Defining the minimum size of a hydrophobic cluster in two-stranded alpha-helical coiled-coils: effects on protein stability.

  Protein science : a publication of the Protein Society 20040301

• Soybean lipoxygenase-3 in complex with 4-nitrocatechol.

  Acta crystallographica. Section D, Biological crystallography 20040301

• Polymeric alkenoxy amino acid surfactants: II. Chiral separations of beta-blockers with multiple stereogenic centers.

  Electrophoresis 20040301

• Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms.

  Archives of neurology 20040301

• Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine.

  The Journal of biological chemistry 20040227

• Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase.

  Biochemistry 20040224

• Outer pore topology of the ECaC-TRPV5 channel by cysteine scan mutagenesis.

  The Journal of biological chemistry 20040220

• GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination.

  The Journal of biological chemistry 20040220

• Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine.

  Bioorganic & medicinal chemistry 20040215

• Evidence for slow motion in proteins by multiple refocusing of heteronuclear nitrogen/proton multiple quantum coherences in NMR.

  Journal of the American Chemical Society 20040211

• Diffusion and dynamics of penetratin in different membrane mimicking media.

  Biochimica et biophysica acta 20040210

• Mutation of a highly conserved isoleucine disrupts hydrophobic interactions in the alpha beta spectrin self-association binding site.

  Laboratory investigation; a journal of technical methods and pathology 20040201

• The combination effect of L-arginine and NaCl on bitterness suppression of amino acid solutions.

  Chemical & pharmaceutical bulletin 20040201

• Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis.

  Plant physiology 20040201

• A new mutation in the hepatocyte nuclear factor-1-alpha gene (P224S) in a newly discovered German family with maturity-onset diabetes of the young 3 (MODY 3). Family members carry additionally the homozygous I27L amino acid polymorphism in the HNF1 alpha gene.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040201

• Dietary isoleucine responses in male broiler chickens.

  British poultry science 20040201

• Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate.

  Journal of nutritional science and vitaminology 20040201

• Superoxide reductase from Desulfoarculus baarsii: identification of protonation steps in the enzymatic mechanism.

  Biochemistry 20040127

• Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase.

  Biochemistry 20040120

• Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor.

  The EMBO journal 20040114

• Central administration of leucine, but not isoleucine and valine, stimulates feeding behavior in neonatal chicks.

  Neuroscience letters 20040109

• Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.

  Diabetes care 20040101

• 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency: impaired catabolism of isoleucine presenting as neurodegenerative disease.

  Brain & development 20040101

• Catabolism of leucine to branched-chain fatty acids in Staphylococcus xylosus.

  Journal of applied microbiology 20040101

• Substitution of isoleucine M206 residue by histidine in the Rhodobacter sphaeroides reaction centers causes changes in the structure of the special bacteriochlorophyll pair molecule.

  Doklady. Biochemistry and biophysics 20040101

• New CACNA1A gene mutation in a case of familial hemiplegic migraine with status epilepticus.

  European neurology 20040101

• [The mobility of the side chains of His57 and other amino acid residues in the active center of chymotrypsin].

  Biofizika 20040101

• [Iatrogenic acrodermatitis enteropathica-like syndrome in leucinosis].

  Annales de dermatologie et de venereologie 20040101

• Fas gene mutations in mycosis fungoides: analysis of laser capture-microdissected specimens from cutaneous lesions.

  Oncology 20040101

• Allele frequencies of hemojuvelin gene (HJV) I222N and G320V missense mutations in white and African American subjects from the general Alabama population.

  BMC medical genetics 20040101

• An early diagnosis leads to a good prognosis: a patient with maple syrup urine disease--screened by tandem mass spectrometry.

  Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi 20040101

• Secondary mutations M36I and A71V in the human immunodeficiency virus type 1 protease can provide an advantage for the emergence of the primary mutation D30N.

  Biochemistry 20031230

• Residue 219 impacts on the dynamics of the C-terminal region in glutathione transferase A1-1: implications for stability and catalytic and ligandin functions.

  Biochemistry 20031230

• Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction.

  The Journal of biological chemistry 20031226

• Isoleucine, a potent plasma glucose-lowering amino acid, stimulates glucose uptake in C2C12 myotubes.

  Biochemical and biophysical research communications 20031226

• Dimerization of cGMP-dependent protein kinase Ibeta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function.

  The Journal of biological chemistry 20031212

• Studies on the biosynthesis of asperparaline A: origin of the spirosuccinimde ring system.

  Journal of the American Chemical Society 20031203

• Fertile eunuch syndrome with the mutations (Trp8Arg and Ile15Thr) in the beta subunit of luteinizing hormone.

  Endocrine journal 20031201

• Calcium triggers beta-defensin (hBD-2 and hBD-3) and chemokine macrophage inflammatory protein-3 alpha (MIP-3alpha/CCL20) expression in monolayers of activated human keratinocytes.

  Experimental dermatology 20031201

• Two genetic variants of the crustacean hyperglycemic hormone (CHH) from the Australian crayfish, Cherax destructor: detection of chiral isoforms due to posttranslational modification.

  Peptides 20031201

• Subdomain VIII is a specificity-determining region in MEKK1.

  The Journal of biological chemistry 20031128

• Functionally important amino acids in Saccharomyces cerevisiae aspartate kinase.

  Biochemical and biophysical research communications 20031121

• Hydrogen-bond cooperativity, vibrational coupling, and dependence of helix stability on changes in amino acid sequence in small 3 10-helical peptides. A density functional theory study.

  Journal of the American Chemical Society 20031119

• Ile, Leu, and Val methyl assignments of the 723-residue malate synthase G using a new labeling strategy and novel NMR methods.

  Journal of the American Chemical Society 20031112

• Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding.

  Biochemistry 20031111

• Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition.

  The Journal of biological chemistry 20031107

• Amprenavir resistance imparted by the I50V mutation in HIV-1 protease can be suppressed by the N88S mutation.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031101

• Selection of the simplest RNA that binds isoleucine.

  RNA (New York, N.Y.) 20031101

• A single nucleotide primer extension assay to detect the APC I1307K gene variant.

  The Journal of molecular diagnostics : JMD 20031101

• Application of robotics to steady state enzyme kinetics: analysis of tight-binding inhibitors of dipeptidyl peptidase IV.

  Analytical biochemistry 20031015

• Unique lipoprotein phenotype and genotype associated with exceptional longevity.

  JAMA 20031015

• Functional consequences of alterations to Ile279, Ile283, Glu284, His285, Phe286, and His288 in the NH2-terminal part of transmembrane helix M3 of the Na+,K(+)-ATPase.

  The Journal of biological chemistry 20031003

• Induction of oxidative stress in rat brain by the metabolites accumulating in maple syrup urine disease.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20031001

• Mutations of the para sodium channel of Drosophila melanogaster identify putative binding sites for pyrethroids.

  Molecular pharmacology 20031001

• Constitutive activation of the angiotensin II type 1 receptor alters the spatial proximity of transmembrane 7 to the ligand-binding pocket.

  The Journal of biological chemistry 20030919

• Evaluation of cooperative interactions between substructures of iso-1-cytochrome c using double mutant cycles.

  Biochemistry 20030916

• Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.

  The Journal of biological chemistry 20030905

• Histidine at position 61 and its adjacent amino acid residues are critical for the ability of SLAM (CD150) to act as a cellular receptor for measles virus.

  The Journal of general virology 20030901

• Apocalmodulin and Ca2+ calmodulin-binding sites on the CaV1.2 channel.

  Biophysical journal 20030901

• An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation.

  Pharmacogenetics 20030901

• Growth hormone receptor variant (L526I) modifies plasma HDL cholesterol phenotype in familial hypercholesterolemia: intra-familial association study in an eight-generation hyperlipidemic kindred.

  American journal of medical genetics. Part A 20030830

• Molecular mechanism of apoptosis: prediction of three-dimensional structure of caspase-6 and its interactions by homology modeling.

  Biochemical and biophysical research communications 20030829

• A human serotonin transporter mutation causes constitutive activation of transport activity.

  Molecular pharmacology 20030801

• Whole-body fluxes and partitioning of amino acids to the mammary gland of cows fed fresh pasture at two levels of intake during early lactation.

  The British journal of nutrition 20030801

• Mutation of the hydrophobic residue on helix alpha5 of the Bacillus thuringiensis Cry4B affects structural stability.

  Protein and peptide letters 20030801

• Diagnosis of maple syrup urine disease by determination of L-valine, L-isoleucine, L-leucine and L-phenylalanine in neonatal blood spots by gas chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030725

• Ternary systems of naproxen with hydroxypropyl-beta-cyclodextrin and aminoacids.

  International journal of pharmaceutics 20030724

• NMR-spectroscopic mapping of an engineered cavity in the I14A mutant of HPr from Staphylococcus carnosus using xenon.

  Journal of the American Chemical Society 20030723

• ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore.

  Human genetics 20030701

• Spectrum of CBS mutations in 16 homocystinuric patients from the Iberian Peninsula: high prevalence of T191M and absence of I278T or G307S.

  Human mutation 20030701

• A new Chrna4 mutation with low penetrance in nocturnal frontal lobe epilepsy.

  Epilepsia 20030701

• Prospective diagnosis of 2-methylbutyryl-CoA dehydrogenase deficiency in the Hmong population by newborn screening using tandem mass spectrometry.

  Pediatrics 20030701

• An isoleucine residue within the carboxyl-transferase domain of multidomain acetyl-coenzyme A carboxylase is a major determinant of sensitivity to aryloxyphenoxypropionate but not to cyclohexanedione inhibitors.

  Plant physiology 20030701

• Inhibition of proteasome activity by selected amino acids.

  Metabolism: clinical and experimental 20030701

• Relationship between glutathione S-transferase P1 polymorphism and bronchial asthma and atopic dermatitis.

  Bulletin of experimental biology and medicine 20030701

• Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides.

  Biochimica et biophysica acta 20030626

• Incorporation of trifluoroisoleucine into proteins in vivo.

  Journal of the American Chemical Society 20030611

• New paraoxonase 1 polymorphism I102V and the risk of prostate cancer in Finnish men.

  Journal of the National Cancer Institute 20030604

• Synchronized prostate cancer cells for studying androgen regulated events in cell cycle progression from G1 into S phase.

  Journal of cellular physiology 20030601

• Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol level.

  The Journal of clinical endocrinology and metabolism 20030601

• Functional characterization of an episodic ataxia type-1 mutation occurring in the S1 segment of hKv1.1 channels.

  Pflugers Archiv : European journal of physiology 20030601

• Evolutionary patterns of codon usage in the chloroplast gene rbcL.

  Journal of molecular evolution 20030601

• The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications.

  Journal of immunology (Baltimore, Md. : 1950) 20030515

• Side chain assignments of Ile delta 1 methyl groups in high molecular weight proteins: an application to a 46 ns tumbling molecule.

  Journal of the American Chemical Society 20030514

• An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor.

  The Journal of biological chemistry 20030509

• Cell surface expression of the melanocortin-4 receptor is dependent on a C-terminal di-isoleucine sequence at codons 316/317.

  The Journal of biological chemistry 20030502

• Kinetic studies on the inhibition of creatine kinase activity by branched-chain alpha-amino acids in the brain cortex of rats.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20030501

• Creatine kinase activity from rat brain is inhibited by branched-chain amino acids in vitro.

  Neurochemical research 20030501

• Requirement of tryptophan in relation to the supply of large neutral amino acids in laying hens.

  Poultry science 20030501

• Production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with high molar fractions of 3-hydroxyvalerate by a threonine-overproducing mutant of Alcaligenes sp. SH-69.

  Biotechnology letters 20030501

• Serine metabolism in human pregnancy.

  American journal of physiology. Endocrinology and metabolism 20030401

• An I47L substitution in the HOXD13 homeodomain causes a novel human limb malformation by producing a selective loss of function.

  Development (Cambridge, England) 20030401

• Finding of an isoleucine derivative of a recombinant protein for pharmaceutical use.

  Journal of pharmaceutical and biomedical analysis 20030401

• Structure-activity relationship of rubiscolins as delta opioid peptides.

  Peptides 20030401

• Lacticin 3147 favours isoleucine transamination by Lactococcus lactis IFPL359 in a cheese-model system.

  Biotechnology letters 20030401

• Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system.

  Biochemical and biophysical research communications 20030328

• Mutants of phosphorylase a altered in recognition by protein phosphatase-1.

  Biochemistry 20030318

• Two novel mutations in the alpha IIb calcium-binding domains identify hydrophobic regions essential for alpha IIbbeta 3 biogenesis.

  Blood 20030315

• The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit.

  The Biochemical journal 20030315

• Distinguishing of Ile/Leu amino acid residues in the PP3 protein by (hot) electron capture dissociation in Fourier transform ion cyclotron resonance mass spectrometry.

  Analytical chemistry 20030315

• Structure of human pro-chymase: a model for the activating transition of granule-associated proteases.

  Biochemistry 20030311

• Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives.

  Journal of the American Chemical Society 20030305

• Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyltransferase.

  Neuromuscular disorders : NMD 20030301

• Effects of a branched-chain amino acid drink in mania.

  The British journal of psychiatry : the journal of mental science 20030301

• Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency.

  Cardiovascular research 20030301

• Two new mutations in cis on (G)gamma chain of fetal hemoglobin: Hb F-Madrid [G gamma 50(D1)Ser-->Cys] and [G gamma 75(E19)Ile-->Thr].

  Annals of hematology 20030301

• HIV-1 protease variants from 100-fold drug resistant clinical isolates: expression, purification, and crystallization.

  Protein expression and purification 20030301

• Isoleucine requirement of growing (25 to 45 kg) pigs.

  Journal of animal science 20030301

• Transthyretin Tyr69-to-Ile mutation (double-nucleotide substitution in codon 69) in a Japanese familial amyloidosis patient with cardiomyopathy and carpal tunnel syndrome.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20030301

• First Spanish family with familial amyloidotic polyneuropathy associated to TTR Thr49Ile mutation.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20030301

• Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy.

  The Journal of biological chemistry 20030227

• O2- and alpha-ketoglutarate-dependent tyrosyl radical formation in TauD, an alpha-keto acid-dependent non-heme iron dioxygenase.

  Biochemistry 20030225

• Characterization of rhodopsin congenital night blindness mutant T94I.

  Biochemistry 20030225

• Residues 207, 216, and 221 and the catalytic activity of mGSTA1-1 and mGSTA2-2 toward benzo[a]pyrene-(7R,8S)-diol-(9S,10R)-epoxide.

  Biochemistry 20030204

• Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.

  Biochemistry 20030204

• Factor VII mutant V154G models a zymogen-like form of factor VIIa.

  The Biochemical journal 20030201

• Directing the mode of nitrite binding to a copper-containing nitrite reductase from Alcaligenes faecalis S-6: characterization of an active site isoleucine.

  Protein science : a publication of the Protein Society 20030201

• A founder effect in the hyperimmunoglobulinemia D and periodic fever syndrome.

  The American journal of medicine 20030201

• Leucine/isoleucine zipper coordination of ion channel macromolecular signaling complexes in the heart. Roles in inherited arrhythmias.

  Trends in cardiovascular medicine 20030201

• Metabolic engineering of valine- and isoleucine-derived glucosinolates in Arabidopsis expressing CYP79D2 from Cassava.

  Plant physiology 20030201

• Skeletal muscle metabolism in Duchenne muscular dystrophy (DMD): an in-vitro proton NMR spectroscopy study.

  Magnetic resonance imaging 20030201

• Properties of chimeric prostacyclin/prostaglandin D2 receptors: site-directed mutagenesis reveals the significance of the isoleucine residue at position 323.

  Journal of receptor and signal transduction research 20030201

• Inhibitor focusing: direct selection of drug targets from proteomes using activity-based probes.

  Assay and drug development technologies 20030201

• The role of the hydrophobic distal heme pocket of CooA in ligand sensing and response.

  The Journal of biological chemistry 20030124

• Enhancing the thermal stability of avidin. Introduction of disulfide bridges between subunit interfaces.

  The Journal of biological chemistry 20030124

• Stability of cyclic beta-hairpins: asymmetric contributions from side chains of a hydrogen-bonded cross-strand residue pair.

  Journal of the American Chemical Society 20030115

• Solution structure and functional ligand screening of HI0719, a highly conserved protein from bacteria to humans in the YjgF/YER057c/UK114 family.

  Biochemistry 20030114

• Dictyostelium myosin II mutations that uncouple the converter swing and ATP hydrolysis cycle.

  Biochemistry 20030114

• Long-term prognosis by lamivudine monotherapy for severe acute exacerbation in chronic hepatitis B infection: emergence of YMDD motif mutant and risk of breakthrough hepatitis -- an open-cohort study.

  Journal of hepatology 20030101

• Crystals of trp repressor suitable for high-resolution neutron Laue diffraction studies.

  Acta crystallographica. Section D, Biological crystallography 20030101

• Influence of the thr164ile polymorphism in the beta2-adrenoceptor on the effects of beta-adrenoceptor agonists on human lung mast cells.

  International immunopharmacology 20030101

• Interactions of various supplies of isoleucine, valine, leucine and tryptophan on the performance of laying hens.

  Poultry science 20030101

• Sex pheromone of the scarab beetle Phyllophaga elenans and some intriguing minor components.

  Journal of chemical ecology 20030101

• Inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity modulates surface expression of CTLA-4 in stress-induced abortions.

  Advances in experimental medicine and biology 20030101

• [Dependence of the composition of the avermectin complex of Streptomyces avermitilis on glucose content of the growth medium].

  Prikladnaia biokhimiia i mikrobiologiia 20030101

• Electrospray mass spectrometric study of anionic complexes of enkephalins with Cu(II): regioselective distinction of Leu/Ile at the C-terminus induced by metal reduction.

  Rapid communications in mass spectrometry : RCM 20030101

• Molecular surveillance of the antifolate-resistant mutation I164L in imported African isolates of Plasmodium falciparum in Europe: sentinel data from TropNetEurop.

  Malaria journal 20030101

• 3-Hydroxy-2-methylbutyryl-CoA dehydrogenase deficiency.

  Journal of inherited metabolic disease 20030101

• Evolution of mosaic operons by horizontal gene transfer and gene displacement in situ.

  Genome biology 20030101

• The source of laterally transferred genes in bacterial genomes.

  Genome biology 20030101

• The mitochondrial acetoacetyl-CoA thiolase (T2) deficiency in Japanese patients: urinary organic acid and blood acylcarnitine profiles under stable conditions have subtle abnormalities in T2-deficient patients with some residual T2 activity.

  Journal of inherited metabolic disease 20030101

• Glutathione S-transferase M1 and P1 metabolic polymorphism and lung cancer predisposition.

  Neoplasma 20030101

• The Aalpha-chain 6Ile/Val polymorphism is not associated with plasma fibrinogen levels in Japanese.

  Thrombosis research 20030101

• Conserved proline residue at position 189 in cone visual pigments as a determinant of molecular properties different from rhodopsins.

  Biochemistry 20021224

• Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression.

  The Journal of biological chemistry 20021220

• Identification of the region of AT2 receptor needed for inhibition of the AT1 receptor-mediated inositol 1,4,5-triphosphate generation.

  FEBS letters 20021218

• Molecular examination of the transmembrane requirements of the platelet-derived growth factor beta receptor for a productive interaction with the bovine papillomavirus E5 oncoprotein.

  The Journal of biological chemistry 20021206

• Heteromultimerization modulates P2X receptor functions through participating extracellular and C-terminal subdomains.

  The Journal of biological chemistry 20021206

• Re: Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk.

  Journal of the National Cancer Institute 20021204

• A heterodimerizing leucine zipper coiled coil system for examining the specificity of a position interactions: amino acids I, V, L, N, A, and K.

  Biochemistry 20021203

• Halide-stabilizing residues of haloalkane dehalogenases studied by quantum mechanic calculations and site-directed mutagenesis.

  Biochemistry 20021203

• Intracellular pyruvate flux in the methane-producing archaeon Methanococcus maripaludis.

  Archives of microbiology 20021201

• Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndrome.

  Human molecular genetics 20021201

• Selective induction of secondary metabolism in Phaseolus lunatus by 6-substituted indanoyl isoleucine conjugates.

  Phytochemistry 20021201

• A novel Val648Ile substitution in RET protooncogene observed in a Cys634Arg multiple endocrine neoplasia type 2A kindred presenting with an adrenocorticotropin-producing pheochromocytoma.

  The Journal of clinical endocrinology and metabolism 20021201

• Characterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene.

  Diabetologia 20021201

• New legume sources as therapeutic agents.

  The British journal of nutrition 20021201

• An isoleucine to leucine mutation in acetyl-CoA carboxylase confers herbicide resistance in wild oat.

  Genome 20021201

• Re-evaluation of the isoleucine requirement of the commercial layer.

  Poultry science 20021201

• Biochemical and mass spectrometric evidence for quaternary structure modifications of plant threonine deaminase induced by isoleucine.

  Biochemistry 20021119

• GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.

  The Journal of biological chemistry 20021108

• Differential scanning calorimetric study of myosin subfragment 1 with tryptic cleavage at the N-terminal region of the heavy chain.

  European journal of biochemistry 20021101

• Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification.

  Arteriosclerosis, thrombosis, and vascular biology 20021101

• Studies on requirement and excess of isoleucine in laying hens.

  Poultry science 20021101

• Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63.

  The Journal of biological chemistry 20021018

• Population-based case-control study of HER2 genetic polymorphism and breast cancer risk.

  Journal of the National Cancer Institute 20021016

• Mutations in the putative pore-forming segment favor short-lived wild-type Kir2.1 pore conformations.

  Biochemistry 20021015

• Leucine stimulates the secretion of hepatocyte growth factor by hepatic stellate cells.

  Biochemical and biophysical research communications 20021011

• Absolute asymmetric photoreactions of aliphatic amino acids by circularly polarized synchrotron radiation: critically pH-dependent photobehavior.

  Journal of the American Chemical Society 20021002

• Regulation of the avidity of ternary complexes containing the human 5-HT(1A) receptor by mutation of a receptor contact site on the interacting G protein alpha subunit.

  British journal of pharmacology 20021001

• Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: ketimine and pyridoxamine phosphate forms.

  Biochemistry 20021001

• Probing Src homology 2 domain ligand interactions by differential line broadening.

  Biochemistry 20021001

• Novel mutations and SNPs identified in CCR2 using a new comprehensive denaturing gradient gel electrophoresis assay.

  Human mutation 20021001

• 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency in a 23-year-old man.

  Journal of inherited metabolic disease 20021001

• Symbiotic characterization of isoleucine+valine and leucine auxotrophs of Sinorhizobium meliloti.

  Indian journal of experimental biology 20021001

• Ferrous ion binding to recombinant human H-chain ferritin. An isothermal titration calorimetry study.

  Biochemistry 20020917

• Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction.

  Journal of cell science 20020901

• The Dermatophagoides pteronyssinus group 2 allergen contains a universally immunogenic T cell epitope.

  Journal of immunology (Baltimore, Md. : 1950) 20020901

• Mechanism of membrane fluidity optimization: isothermal control of the Bacillus subtilis acyl-lipid desaturase.

  Molecular microbiology 20020901

• Effect of a new injectable male contraceptive on the seminal plasma amino acids studied by proton NMR spectroscopy.

  Contraception 20020901

• Discrimination of tRNA(Leu) isoacceptors by the mutants of Escherichia coli leucyl-tRNA synthetase in editing.

  Biochemistry 20020827

• Attenuation of the editing activity of the Escherichia coli leucyl-tRNA synthetase allows incorporation of novel amino acids into proteins in vivo.

  Biochemistry 20020827

• Redox-dependent structural changes in the superoxide reductase from Desulfoarculus baarsii and Treponema pallidum: a FTIR study.

  Biochemistry 20020813

• Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity.

  The Journal of biological chemistry 20020809

• Biosynthesis of the branched-chain amino acids in the cyanobacterium Synechocystis PCC6803: existence of compensatory pathways.

  Current microbiology 20020801

• I591T MEFV mutation in a Spanish kindred: is it a mild mutation, a benign polymorphism, or a variant influenced by another modifier?

  Human mutation 20020801

• CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm.

  Gynecologic oncology 20020801

• Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26).

  Journal of neuroimmunology 20020801

• Stimulatory and inhibitory effects of protein amino acids on growth rate and efficiency of mixed ruminal bacteria.

  Journal of dairy science 20020801

• Side chain NMR assignments in the membrane protein OmpX reconstituted in DHPC micelles.

  Journal of biomolecular NMR 20020801

• The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate.

  The Journal of biological chemistry 20020719

• RET and anisotropy measurements establish the proximity of the conserved Trp17 to Ile98 and Phe99 of tear lipocalin.

  Biochemistry 20020716

• Site-directed glycosylation tagging of functional Kir2.1 reveals that the putative pore-forming segment is extracellular.

  The Journal of biological chemistry 20020705

• Ile (476), a constituent of di-leucine-based motif of a major lysosomal membrane protein, LGP85/LIMP II, is important for its proper distribution in late endosomes and lysosomes.

  Biochemical and biophysical research communications 20020705

• Biosynthesis of strawberry aroma compounds through amino acid metabolism.

  Journal of agricultural and food chemistry 20020703

• The importance of region 2.1 in sustaining the functional structure of the Bacillus subtilis sigma(A) factor.

  Journal of biochemistry 20020701

• A critical motif for oligomerization and chaperone activity of bacterial alpha-heat shock proteins.

  European journal of biochemistry 20020701

• Influence of supplemental lysine, isoleucine, threonine, tryptophan and total sulfur amino acids on egg weight of Hy-line W-36 hens.

  Poultry science 20020701

• Rational design to block amino acid editing of a tRNA synthetase.

  Journal of the American Chemical Society 20020626

• Identification of essential residues in the type II Hsp40 Sis1 that function in polypeptide binding.

  The Journal of biological chemistry 20020614

• Salicylate biosynthesis in Pseudomonas aeruginosa. Purification and characterization of PchB, a novel bifunctional enzyme displaying isochorismate pyruvate-lyase and chorismate mutase activities.

  The Journal of biological chemistry 20020614

• Interhelical interactions in the gp41 core: implications for activation of HIV-1 membrane fusion.

  Biochemistry 20020611

• Site-directed mutagenesis of the gerbil and human angiotensin II AT(1) receptors identifies amino acid residues attributable to the binding affinity for the nonpeptidic antagonist losartan.

  Molecular pharmacology 20020601

• Substitution of isoleucine-31 by helical-breaking proline abolishes oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide.

  Free radical biology & medicine 20020601

• Amino acid residue 67 (isoleucine) of HLA-DRB is associated with POHS.

  Investigative ophthalmology & visual science 20020601

• Diagnosis and treatment of maple syrup disease: a study of 36 patients.

  Pediatrics 20020601

• Evaluation of isoleucine, leucine, and valine as a second-limiting amino acid for milk production in dairy cows fed grass silage diet.

  Journal of dairy science 20020601

• Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes.

  The Journal of biological chemistry 20020531

• Role of tryptophan residues in interfacial binding of phosphatidylinositol-specific phospholipase C.

  The Journal of biological chemistry 20020531

• Thermal stability of calmodulin and mutants studied by (1)H-(15)N HSQC NMR measurements of selectively labeled [(15)N]Ile proteins.

  Biochemistry 20020528

• EPR studies on a stable sulfinyl radical observed in the iron-oxygen-reconstituted Y177F/I263C protein R2 double mutant of ribonucleotide reductase from mouse.

  Biochemistry 20020521

• Expression of Escherichia coli glutaredoxin 2 is mainly regulated by ppGpp and sigmaS.

  The Journal of biological chemistry 20020517

• Analysis of fibrinogen gamma-chain truncations shows the C-terminus, particularly gammaIle387, is essential for assembly and secretion of this multichain protein.

  Blood 20020515

• Altered trafficking and adhesion function of MPZ mutations and phenotypes of Charcot-Marie-Tooth disease 1B.

  Acta neuropathologica 20020501

• Regulation of ryanodine receptors via macromolecular complexes: a novel role for leucine/isoleucine zippers.

  Trends in cardiovascular medicine 20020501

• Clinical variability in 3-hydroxy-2-methylbutyryl-CoA dehydrogenase deficiency.

  Annals of neurology 20020501

• Structure, energetics and reactivity of ternary complexes of amino acids with Cu(II) and 2,2'-bipyridine by density functional theory. A combination of radical-induced and spin-remote fragmentations.

  Journal of mass spectrometry : JMS 20020501

• Lambdap(o), a promoter for oop RNA synthesis, has a role in replication of plasmids derived from bacteriophage lambda.

  Plasmid 20020501

• Mapping the epitope of an inhibitory monoclonal antibody to the C-terminal DNA-binding domain of HIV-1 integrase.

  The Journal of biological chemistry 20020405

• Engineered recombinant enteropeptidase catalytic subunit: effect of N-terminal modification.

  Archives of biochemistry and biophysics 20020401

• Ideal ratio (relative to lysine) of tryptophan, threonine, isoleucine, and valine for chicks during the second and third weeks posthatch.

  Poultry science 20020401

• Transfer ribonucleic acid charging in rat brain after consumption of amino acid-imbalanced diets.

  Nutritional neuroscience 20020401

• Cytoplasmic vestibule of the weak inward rectifier Kir6.2 potassium channel.

  The Journal of biological chemistry 20020322

• Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin.

  The Journal of biological chemistry 20020308

• Controlling ligand binding in myoglobin by mutagenesis.

  The Journal of biological chemistry 20020301

• Isoleucine starvation caused by sulfometuron methyl in Salmonella typhimurium measured by translational frameshifting.

  Microbiology (Reading, England) 20020301

• Genetic polymorphisms of cytochrome P450 1A1 and risk of gallbladder cancer.

  Journal of experimental & clinical cancer research : CR 20020301

• Amino acids 67 and 68 of transforming growth factor-beta regulate binding to a glycosyl phosphatidyl inositol-linked membrane protein on vascular endothelial cells.

  Cytokines, cellular & molecular therapy 20020301

• Flow cytometry as a useful tool for process development: rapid evaluation of expression systems.

  Journal of biotechnology 20020227

• Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.

  Journal of molecular biology 20020222

• Existence of beta-methylnorleucine in recombinant hirudin produced by Escherichia coli.

  Journal of biotechnology 20020214

• Regulatory interactions in Arabidopsis thaliana acetohydroxyacid synthase.

  FEBS letters 20020213

• Single synonymous codon substitution eliminates pausing during chloramphenicol acetyl transferase synthesis on Escherichia coli ribosomes in vitro.

  FEBS letters 20020213

• Hydration effects of heparin on antithrombin probed by osmotic stress.

  Biophysical journal 20020201

• The N-terminal region of Arabidopsis cystathionine gamma-synthase plays an important regulatory role in methionine metabolism.

  Plant physiology 20020201

• Mutational separation of two pathways for editing by a class I tRNA synthetase.

  Molecular cell 20020201

• Evaluation of circulating levels and renal clearance of natural amino acids in patients with Cushing's disease.

  Journal of endocrinological investigation 20020201

• N-terminal contributions of the gamma-subunit of fetal hemoglobin to its tetramer strength: remote effects at subunit contacts.

  Protein science : a publication of the Protein Society 20020101

• An isoleucine-leucine substitution in chloroplastic acetyl-CoA carboxylase from green foxtail (Setaria viridis L. Beauv.) is responsible for resistance to the cyclohexanedione herbicide sethoxydim.

  Planta 20020101

• Probing substrate binding to metallo-beta-lactamase L1 from Stenotrophomonas maltophilia by using site-directed mutagenesis.

  BMC biochemistry 20020101

• A possible mechanism for partitioning between homo- and heterodimerization of the yeast homeodomain proteins MATa1 and MATalpha2.

  The journal of peptide research : official journal of the American Peptide Society 20020101

• The influence of amino acid side chains on water binding to the copper(II) in bis(N,N-dimethyl-L-alpha-isoleucinato)-copper(II): an EPR and molecular mechanics study.

  Cellular & molecular biology letters 20020101

• Side-chain radical losses from radical cations allows distinction of leucine and isoleucine residues in the isomeric peptides Gly-XXX-Arg.

  Rapid communications in mass spectrometry : RCM 20020101

• [Identification of T274I mutation in the SMN1 gene in a patient with spinal muscular atrophy].

  Medycyna wieku rozwojowego 20020101

• Concentrations of branched amino acids: isoleucine, valine, leucine in serum of hemodialysis patients during one-year observation.

  Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20020101

• Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase.

  The Journal of biological chemistry 20011214

• ATP synthase F(1) sector rotation. Defective torque generation in the beta subunit Ser-174 to Phe mutant and its suppression by second mutations.

  The Journal of biological chemistry 20011214

• The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different.

  The Journal of biological chemistry 20011214

• Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region.

  FEBS letters 20011214

• Effect of site-directed asparagine to isoleucine substitutions at the N-linked E1 glycosylation sites on rubella virus viability.

  Virus research 20011204

• Metabolic redirection of carbon flow toward isoleucine by expressing a catabolic threonine dehydratase in a threonine-overproducing Corynebacterium glutamicum.

  Applied microbiology and biotechnology 20011201

• Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration.

  Nature cell biology 20011201

• Mutational analysis of the three conserved valine residues of insulin and a proposal of 'isosteric residue'.

  IUBMB life 20011201

• Energetics of side chain packing in staphylococcal nuclease assessed by exchange of valines, isoleucines, and leucines.

  Biochemistry 20011120

• Extracellular Toll-like receptor 2 region containing Ser40-Ile64 but not Cys30-Ser39 is critical for the recognition of Staphylococcus aureus peptidoglycan.

  The Journal of biological chemistry 20011102

• Recovering antibody secretion using a hapten ligand as a chemical chaperone.

  The Journal of biological chemistry 20011102

• Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal.

  Journal of lipid research 20011101

• Expression of Neisseria gonorrhoeae cell division genes ftsZ, ftsE and minD is influenced by environmental conditions.

  Research in microbiology 20011101

• Long-range effects on calcium binding and conformational change in the N-domain of calmodulin.

  Biochemistry 20011023

• Metabolic oscillations in an E. coli fermentation.

  Biotechnology and bioengineering 20011020

• Site-directed mutagenesis of m1-toxin1: two amino acids responsible for stable toxin binding to M(1) muscarinic receptors.

  Molecular pharmacology 20011001

• Novel site on sodium channel alpha-subunit responsible for the differential sensitivity of grayanotoxin in skeletal and cardiac muscle.

  Molecular pharmacology 20011001

• Hydrophobic residues Phe552, Phe554, Ile562, Leu566, and Ile574 are required for oligomerization of anthrax protective antigen.

  Biochemical and biophysical research communications 20010921

• Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression.

  Psychiatry research 20010920

• A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyrethroid action.

  Molecular pharmacology 20010901

• Functional expression and stabilization of horseradish peroxidase by directed evolution in Saccharomyces cerevisiae.

  Biotechnology and bioengineering 20010901

• Arginine-140 and isoleucine-141 determine the 17beta-estradiol-binding specificity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.

  Protein science : a publication of the Protein Society 20010901

• [Maple syrup urine disease].

  La Radiologia medica 20010901

• Identification of inactivation determinants in the domain IIS6 region of high voltage-activated calcium channels.

  The Journal of biological chemistry 20010831

• Mutation of residues 423 (Met/Ile), 444 (Thr/Met), and 506 (Asn/Ser) confer cholesteryl esterase activity on rat lung carboxylesterase. Ser-506 is required for activation by cAMP-dependent protein kinase.

  The Journal of biological chemistry 20010831

• Selective functionalization of amino acids in water: a synthetic method via catalytic C-H bond activation.

  Journal of the American Chemical Society 20010822

• Mutation of a single conserved residue in VH complementarity-determining region 2 results in a severe Ig secretion defect.

  Journal of immunology (Baltimore, Md. : 1950) 20010815

• The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

  The EMBO journal 20010815

• Distinct functional surface regions on ubiquitin.

  The Journal of biological chemistry 20010810

• Effect of protein restriction on (15)N transfer from dietary [(15)N]alanine and [(15)N]Spirulina platensis into urea.

  American journal of physiology. Endocrinology and metabolism 20010801

• BCAA intake affects protein metabolism in muscle after but not during exercise in humans.

  American journal of physiology. Endocrinology and metabolism 20010801

• Results of a phase I trial evaluating a liver support device utilizing albumin dialysis.

  Surgery 20010801

• Effects of branched-chain amino acids on placental amino acid transfer and insulin and glucagon release in the ovine fetus.

  American journal of obstetrics and gynecology 20010801

• A transition-state analogue reduces protein dynamics in hypoxanthine-guanine phosphoribosyltransferase.

  Biochemistry 20010710

• Misacylation and editing by Escherichia coli valyl-tRNA synthetase: evidence for two tRNA binding sites.

  Biochemistry 20010710

• Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis.

  The Journal of biological chemistry 20010706

• Initial catabolic steps of isoleucine, the R-pathway and the origin of alloisoleucine.

  Journal of chromatography. B, Biomedical sciences and applications 20010705

• The factor VII zymogen structure reveals reregistration of beta strands during activation.

  Structure (London, England : 1993) 20010703

• Genetic analysis of the signalling pathway activated by external amino acids in Saccharomyces cerevisiae.

  Molecular microbiology 20010701

• The roles of the N-terminal portions of various tachykinins in promoting salivation.

  Oral diseases 20010701

• The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable.

  The Journal of biological chemistry 20010601

• A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae.

  Genes to cells : devoted to molecular & cellular mechanisms 20010601

• Tolerance of point substitution of methionine for isoleucine in hen egg white lysozyme.

  Protein engineering 20010601

• Role of surface lysine residues of adipocyte fatty acid-binding protein in fatty acid transfer to phospholipid vesicles.

  Biochemistry 20010529

• Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase.

  Biochemistry 20010522

• Inhibition of dipeptidyl peptidase IV (DP IV, CD26) activity abrogates stress-induced, cytokine-mediated murine abortions.

  Scandinavian journal of immunology 20010501

• The amino-terminal tail of glycogen phosphorylase is a switch for controlling phosphorylase conformation, activation, and response to ligands.

  Biochemistry 20010501

• A single residue differentiates between human cardiac and skeletal muscle Na+ channel slow inactivation.

  Biophysical journal 20010501

• The amino acid residues affecting the activity and azole susceptibility of rat CYP51 (sterol 14-demethylase P450).

  Journal of biochemistry 20010501

• Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis.

  Brain : a journal of neurology 20010501

• Dissociation pathways of alkali-cationized peptides: opportunities for C-terminal peptide sequencing.

  Journal of the American Society for Mass Spectrometry 20010501

• Why do female Aedes aegypti (Diptera: Culicidae) feed preferentially and frequently on human blood?

  Journal of medical entomology 20010501

• Methods for synchronizing cells at specific stages of the cell cycle.

  Current protocols in cell biology 20010501

• Tyrosine 331 and phenylalanine 334 in Clostridium perfringens alpha-toxin are essential for cytotoxic activity.

  FEBS letters 20010427

• Superoxide reductase from Desulfoarculus baarsii: reaction mechanism and role of glutamate 47 and lysine 48 in catalysis.

  Biochemistry 20010424

• Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.

  Bioorganic & medicinal chemistry letters 20010423

• Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.

  Bioorganic & medicinal chemistry letters 20010423

• Mechanism of dihydropyridine interaction with critical binding residues of L-type Ca2+ channel alpha 1 subunits.

  The Journal of biological chemistry 20010420

• Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase.

  Journal of the American Chemical Society 20010418

• Studies on the biosynthesis of paraherquamide: concerning the mechanism of the oxidative cyclization of L-isoleucine to beta-methylproline.

  Journal of the American Chemical Society 20010411

• Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein.

  Biochemistry 20010410

• Re: Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk.

  Journal of the National Cancer Institute 20010404

• Distinguishing self from nonself: immunogenicity of the murine H47 locus is determined by a single amino acid substitution in an unusual peptide.

  Journal of immunology (Baltimore, Md. : 1950) 20010401

• Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.

  Journal of neurochemistry 20010401

• Aspartate kinase 2. A candidate gene of a quantitative trait locus influencing free amino acid content in maize endosperm.

  Plant physiology 20010401

• Leucine and protein metabolism in rats with chronic renal insufficiency.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20010401

• Substituted hydrophobic and hydrophilic residues at methionine-68 influence the chaperone-like function of alphaB-crystallin.

  Molecular and cellular biochemistry 20010401

• Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid.

  The Journal of biological chemistry 20010330

• [Significance of trypsinogen gene mutations in the etiology of hereditary pancreatitis].

  Orvosi hetilap 20010325

• Helix packing in the lactose permease of Escherichia coli: distances between site-directed nitroxides and a lanthanide.

  Biochemistry 20010313

• The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa.

  The Journal of biological chemistry 20010309

• Molecular mechanism for functional interaction between DnaA protein and acidic phospholipids: identification of important amino acids.

  The Journal of biological chemistry 20010309

• Direct comparison of experimental and calculated folding free energies for hydrophobic deletion mutants of chymotrypsin inhibitor 2: free energy perturbation calculations using transition and denatured states from molecular dynamics simulations of unfolding.

  Biochemistry 20010306

• Structural and functional analysis of the HIV gp41 core containing an Ile573 to Thr substitution: implications for membrane fusion.

  Biochemistry 20010306

• Hydrophobic analogues of the winter flounder 'antifreeze' protein.

  FEBS letters 20010302

• Ligand migration in human myoglobin: steric effects of isoleucine 107(G8) on O(2) and CO binding.

  Biophysical journal 20010301

• Identification of a novel single-nucleotide polymorphism (Val554Ile) and definition of eight common alleles for human IL4RA exon 11.

  Tissue antigens 20010301

• Sequence information, distinction and quantitation of C-terminal leucine and isoleucine in ternary complexes of tripeptides with Cu(II) and 2,2'-bipyridine.

  Journal of mass spectrometry : JMS 20010301

• Substitutions of Thr-103-Ile and Trp-138-Gly in amidase from Pseudomonas aeruginosa are responsible for altered kinetic properties and enzyme instability.

  Molecular biotechnology 20010301

• Blunted cardiac responses to receptor activation in subjects with Thr164Ile beta(2)-adrenoceptors.

  Circulation 20010227

• The C-terminal tail of UNC-60B (actin depolymerizing factor/cofilin) is critical for maintaining its stable association with F-actin and is implicated in the second actin-binding site.

  The Journal of biological chemistry 20010223

• Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9.

  Biochemistry 20010220

• A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity.

  The Journal of biological chemistry 20010216

• Evidence that fragile X mental retardation protein is a negative regulator of translation.

  Human molecular genetics 20010215

• Enhancement, relaxation, and reversal of the stereoselectivity for phosphotriesterase by rational evolution of active site residues.

  Biochemistry 20010206

• Hormone interactions to Leu-rich repeats in the gonadotropin receptors. II. Analysis of Leu-rich repeat 4 of human luteinizing hormone/chorionic gonadotropin receptor.

  The Journal of biological chemistry 20010202

• An activation switch in the ligand binding pocket of the C5a receptor.

  The Journal of biological chemistry 20010202

• Fragmentary form of thermostable leucine dehydrogenase of Bacillus stearothermophilus: its construction and reconstitution of active fragmentary enzyme.

  Biochemical and biophysical research communications 20010202

• Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells.

  Diabetes 20010201

• Protein control of the redox potential of the primary quinone acceptor in reactioncCenters from Rhodobacter sphaeroides.

  Biochemistry 20010130

• Metabolism of glucagon by dipeptidyl peptidase IV (CD26).

  Regulatory peptides 20010112

• The Val-210-Ile pathogenic Creutzfeldt-Jakob disease mutation increases both the helical and aggregation propensities of a sequence corresponding to helix-3 of PrP(C).

  Biochimica et biophysica acta 20010112

• An in vivo study of ovine placental transport of essential amino acids.

  American journal of physiology. Endocrinology and metabolism 20010101

• Protective function of p27(KIP1) against apoptosis in small cell lung cancer cells in unfavorable microenvironments.

  The American journal of pathology 20010101

• Precursor supply for polyketide biosynthesis: the role of crotonyl-CoA reductase.

  Metabolic engineering 20010101

• Incidence of the endothelin receptor B mutation that causes lethal white foal syndrome in white-patterned horses.

  American journal of veterinary research 20010101

• Metabolism of branched-chain amino acids in starved rats: the role of hepatic tissue.

  Physiological research 20010101

• Influence of antioxidants and the CYP1A1 isoleucine to valine polymorphism on the smoking--lung cancer association.

  Anticancer research 20010101

• The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules.

  BMC bioinformatics 20010101

• Replacement of tyrosine-197 and the corresponding tyrosine-195 to isoleucine in Cephalosporium acremonium and Streptomyces clavuligerus isopenicillin N synthase.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101

• Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance.

  Structure (London, England : 1993) 20001215

• Activity of allelic variants of Pi class human glutathione S-transferase toward chlorambucil.

  Biochemical and biophysical research communications 20001111

• Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis.

  Therapeutic drug monitoring 20000601

• Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.

  Biochemistry 19990622

• Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs.

  Nucleic acids research 19990215

• Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors.

  Journal of neurochemistry 19961101

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