152520-56-4 | Nebivolol hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
5mg	97%	in stock	$48.00	$34.00
20mg	97%	in stock	$77.00	$54.00
50mg	97%	in stock	$144.00	$101.00
100mg	97%	in stock	$228.00	$159.00

Description

• Catalog Number: AD71212
• Chemical Name: Nebivolol hydrochloride
• CAS Number: 152520-56-4
• Molecular Formula: C22H26ClF2NO4
• Molecular Weight: 441.8959
• MDL Number: MFCD07357273
• SMILES: O[C@H]([C@@H]1CCc2c(O1)ccc(c2)F)CNC[C@@H]([C@H]1CCc2c(O1)ccc(c2)F)O.Cl

Computed Properties

• Complexity: 483
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 6

Literature

• Nebivolol stimulates mitochondrial biogenesis in 3T3-L1 adipocytes.

  Biochemical and biophysical research communications 20130816

• Effect of carvedilol and nebivolol on oxidative stress-related parameters and endothelial function in patients with essential hypertension.

  Basic & clinical pharmacology & toxicology 20121101

• Effect of nebivolol on outcome in elderly patients with heart failure and atrial fibrillation: insights from SENIORS.

  European journal of heart failure 20121001

• Efficacy and tolerability of nebivolol: does age matter? A retrospective analysis of three randomized, placebo-controlled trials in stage I-II hypertension.

  Therapeutic advances in cardiovascular disease 20121001

• Topical effects of nebivolol on wounds in diabetic rats.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120929

• Vascular effects of nebivolol added to hydrochlorothiazide in African Americans with hypertension and echocardiographic evidence of diastolic dysfunction: the NASAA study.

  Journal of cardiovascular pharmacology and therapeutics 20120901

• Nebivolol-induced vasodilation of renal afferent arterioles involves β3-adrenergic receptor and nitric oxide synthase activation.

  American journal of physiology. Renal physiology 20120901

• The effect of valsartan and nebivolol treatment on ADMA and pentraxin-3 levels in hypertensive patients.

  Medical hypotheses 20120901

• Nebivolol and metoprolol: long-term effects on inflammation and oxidative stress in essential hypertension.

  Scandinavian journal of clinical and laboratory investigation 20120901

• Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats.

  Journal of hypertension 20120901

• Blood pressure effects of combined β-blocker and angiotensin-converting enzyme inhibitor therapy compared with the individual agents: a placebo-controlled study with nebivolol and lisinopril.

  Journal of clinical hypertension (Greenwich, Conn.) 20120901

• Protective effects of nebivolol against cold restraint stress-induced gastric ulcer in rats: role of NO, HO-1, and COX-1,2.

  Nitric oxide : biology and chemistry 20120815

• Effect of nebivolol on beat-to-beat and short-term blood pressure variability in spontaneously hypertensive rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20120801

• Nebivolol does not protect against 5/6 ablation/infarction induced chronic kidney disease in rats - comparison with angiotensin II receptor blockade.

  Life sciences 20120726

• Rapid and economic chiral-HPLC method of nebivolol enantiomers resolution in dosage formulation.

  Biomedical chromatography : BMC 20120601

• Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat.

  American journal of physiology. Heart and circulatory physiology 20120601

• The effects of newer beta-adrenoceptor antagonists on vascular function in cardiovascular disease.

  Current vascular pharmacology 20120501

• Successful treatment of intravascular papillary endothelial hyperplasia (IPEH) by the beta-adrenergic antagonist nebivolol.

  The British journal of dermatology 20120501

• Nebivolol therapy improves QTc and QTcd parameters in heart failure patients.

  Cardiovascular journal of Africa 20120501

• Does nebivolol prevent contrast-induced nephropathy in humans?

  Clinical cardiology 20120401

• Persistence with nebivolol in the treatment of hypertension: a retrospective claims analysis.

  Current medical research and opinion 20120401

• Differential effects of nebivolol and metoprolol on insulin sensitivity and plasminogen activator inhibitor in the metabolic syndrome.

  Hypertension (Dallas, Tex. : 1979) 20120401

• Nebivolol regulates eNOS and iNOS expressions and alleviates oxidative stress in cerebral ischemia/reperfusion injury in rats.

  Life sciences 20120310

• Effects of nebivolol or irbesartan in combination with hydrochlorothiazide on vascular functions in newly-diagnosed hypertensive patients: the NINFE (Nebivololo, Irbesartan Nella Funzione Endoteliale) study.

  International journal of cardiology 20120308

• The beneficial effects of nebivolol on endothelial functions in arterial hypertension.

  International journal of cardiology 20120308

• Protective actions of nebivolol on chronic nitric oxide synthase inhibition-induced hypertension and chronic kidney disease in the rat: a comparison with angiotensin II receptor blockade.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20120301

• Vasodilating versus first-generation β-blockers for cardiovascular protection.

  Postgraduate medicine 20120301

• Effects of the long-term administration of nebivolol on the clinical symptoms, exercise capacity, and left ventricular function of patients with diastolic dysfunction: results of the ELANDD study.

  European journal of heart failure 20120201

• β-blockade: benefits beyond blood pressure reduction?

  Journal of clinical hypertension (Greenwich, Conn.) 20120201

• The anti-oxidant and anti-apoptotic effects of nebivolol and zofenopril in a model of cerebral ischemia/reperfusion in rats.

  Progress in neuro-psychopharmacology & biological psychiatry 20120110

• Nebivolol: an endothelium-friendly selective β1-adrenoceptor blocker.

  Journal of cardiovascular pharmacology 20120101

• Both morning and evening dosing of nebivolol reduces trough mean blood pressure surge in hypertensive patients.

  Journal of the American Society of Hypertension : JASH 20120101

• Nebivolol withdrawal results in blood pressure returning toward pretreatment levels, but without rebound symptoms: phase IV randomized trial.

  Journal of the American Society of Hypertension : JASH 20120101

• Nebivolol: impact on cardiac and endothelial function and clinical utility.

  Vascular health and risk management 20120101

• Beta-adrenergic receptor 1 selective antagonism inhibits norepinephrine-mediated TNF-alpha downregulation in experimental liver cirrhosis.

  PloS one 20120101

• Nebivolol prevents myocardial fibrosis and diastolic dysfunction in salt-loaded spontaneously hypertensive rats.

  Journal of the American Society of Hypertension : JASH 20120101

• The effect of AVE 0991, nebivolol and doxycycline on inflammatory mediators in an apoE-knockout mouse model of atherosclerosis.

  Medical science monitor : international medical journal of experimental and clinical research 20120101

• The use of beta blocker Nebivolol in patients with chronic obstructive pulmonary disease in association with arterial hypertension.

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20120101

• [Prospective follow-up of nebivolol in the treatment of arterial hypertension].

  Srpski arhiv za celokupno lekarstvo 20120101

• Beta3-adrenoreceptor stimulation ameliorates myocardial ischemia-reperfusion injury via endothelial nitric oxide synthase and neuronal nitric oxide synthase activation.

  Journal of the American College of Cardiology 20111213

• Beta3-adrenoceptor activation just says NO to myocardial reperfusion injury.

  Journal of the American College of Cardiology 20111213

• Nebivolol improves insulin sensitivity in the TGR(Ren2)27 rat.

  Metabolism: clinical and experimental 20111201

• Nebivolol for the treatment of heart failure.

  Expert opinion on investigational drugs 20111201

• Comparison between nebivolol and ramipril in patients with hypertension and left ventricular hypertrophy: a randomized open blinded end-point (PROBE) trial.

  European review for medical and pharmacological sciences 20111201

• An approach for rapid development of nasal delivery of analgesics--identification of relevant features, in vitro screening and in vivo verification.

  International journal of pharmaceutics 20111125

• The role of nebivolol in the prevention of contrast-induced nephropathy in patients with renal dysfunction.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20111101

• The role of nebivolol in the prevention of contrast-induced nephropathy.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20111101

• Combined antihypertensive and cardioprotective effects of nebivolol and hydrochlorothiazide in spontaneous hypertensive rats.

  Future cardiology 20111101

• NEbivolol inhibition of coronary artery smooth muscle cell proliferation after percutaneous coronary artery intervention. Results of the NESCIO Study, a randomized, double blind trial.

  European review for medical and pharmacological sciences 20111101

• Protective effect of beta-glucan on contrast induced-nephropathy and a comparison of beta-glucan with nebivolol and N-acetylcysteine in rats.

  Clinical and experimental nephrology 20111001

• [Comparative effects of nebivolol and valsartan on atrial electromechanical coupling in newly diagnosed stage 1 hypertensive patients].

  Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20111001

• Vascular endothelial function in patients with coronary slow flow and the effects of nebivolol.

  Arquivos brasileiros de cardiologia 20111001

• [Young patient with mild hypertension: angiotensin inhibitor or beta blocker?].

  MMW Fortschritte der Medizin 20110922

• Efficacy and tolerability of nebivolol in stage I-II hypertension: a pooled analysis of data from three randomized, placebo-controlled monotherapy trials.

  Clinical therapeutics 20110901

• Comparative long term effects of nebivolol and carvedilol in hypertensive heart failure patients.

  Journal of cardiac failure 20110901

• Improvement of left ventricular diastolic function induced by β-blockade: a comparison between nebivolol and metoprolol.

  Journal of molecular and cellular cardiology 20110801

• β-Blockers in patients with intermittent claudication and arterial hypertension: results from the nebivolol or metoprolol in arterial occlusive disease trial.

  Hypertension (Dallas, Tex. : 1979) 20110801

• Long-term treatment with nebivolol attenuates renal damage in Zucker diabetic fatty rats.

  Journal of hypertension 20110801

• Effects of nebivolol on vascular endothelial and myocardial function in diabetes mellitus.

  Journal of cardiovascular pharmacology 20110701

• The use of 24-h ambulatory blood pressure monitoring (ABPM) during the first cycle of sunitinib improves the diagnostic accuracy and management of hypertension in patients with advanced renal cancer.

  European journal of cancer (Oxford, England : 1990) 20110701

• Mitochondriocentric pathway to cardiomyocyte necrosis in aldosteronism: cardioprotective responses to carvedilol and nebivolol.

  Journal of cardiovascular pharmacology 20110701

• Effect of nebivolol vs. hydrochlorothiazide on the walking capacity in hypertensive patients with intermittent claudication.

  Journal of hypertension 20110701

• Lowering blood pressure with β-blockers in peripheral artery disease: the importance of comorbidity.

  Journal of hypertension 20110701

• Rate-limiting step: can different effects of antihypertensives on central blood pressure be translated into outcomes?

  Hypertension (Dallas, Tex. : 1979) 20110601

• Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness.

  Hypertension (Dallas, Tex. : 1979) 20110601

• Comparison of antihypertensive efficacy of carvedilol and nebivolol in mild-to-moderate primary hypertension: a randomized trial.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20110601

• Anaemia among patients with heart failure and preserved or reduced ejection fraction: results from the SENIORS study.

  European journal of heart failure 20110601

• Managing erectile dysfunction in hypertensive patients.

  Journal of clinical hypertension (Greenwich, Conn.) 20110601

• Nebivolol for the treatment of heart failure.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110515

• Effects of commonly administered agents and genetics on nebivolol pharmacokinetics: drug-drug interaction studies.

  Journal of clinical pharmacology 20110401

• The role of Beta-blockers as first-line therapy in hypertension.

  Current atherosclerosis reports 20110401

• Reversal of subclinical left ventricular dysfunction by antihypertensive treatment: a prospective trial of nebivolol against metoprolol.

  Journal of hypertension 20110401

• Heart failure: acute ischemic events in HF--should we include sudden death?

  Nature reviews. Cardiology 20110401

• Nebivolol has protective effect against endothelial and ileal dysfunction due to I/R.

  The Journal of surgical research 20110301

• Effects of nebivolol in obese African Americans with hypertension (NOAAH): markers of inflammation and obesity in response to exercise-induced stress.

  Journal of human hypertension 20110301

• Lack of evidence that nebivolol is a β₃-adrenoceptor agonist.

  European journal of pharmacology 20110301

• Effects of selective and nonselective beta-blockade on 24-h ambulatory blood pressure under hypobaric hypoxia at altitude.

  Journal of hypertension 20110201

• β-blockade with nebivolol for prevention of acute ischaemic events in elderly patients with heart failure.

  Heart (British Cardiac Society) 20110201

• Nebivolol attenuates redox-sensitive glomerular and tubular mediated proteinuria in obese rats.

  Endocrinology 20110201

• Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional β1-blockade.

  Journal of the American College of Cardiology 20110201

• The effect of nebivolol on asymmetric dimethylarginine system in spontaneously hypertension rats.

  Vascular pharmacology 20110101

• The effect of nebivolol versus metoprolol succinate extended release on asymmetric dimethylarginine in hypertension.

  Journal of the American Society of Hypertension : JASH 20110101

• [Efficacy of nebivolol in patients with coronary heart disease and concomitant chronic obstructive pulmonary disease].

  Klinicheskaia meditsina 20110101

• [Comparative analysis of antioxidant activity of nebivolol in patients with chronic heart failure with and without concomitant type 2 diabetes].

  Kardiologiia 20110101

• Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol.

  American journal of nephrology 20101201

• Efficacy and safety of nebivolol in Hispanics with stage I-II hypertension: a randomized placebo-controlled trial.

  Therapeutic advances in cardiovascular disease 20101201

• Quantification of nebivolol hydrochloride in human plasma by liquid chromatography using fluorescence detection: Use in pharmacokinetic study.

  Drug discoveries & therapeutics 20101201

• The foundation role of beta blockers across the cardiovascular disease spectrum: a year 2009 update.

  The American journal of medicine 20101101

• Different patterns of peripheral versus central blood pressure in hypertensive patients treated with β-blockers either with or without vasodilator properties or with angiotensin receptor blockers.

  Blood pressure monitoring 20101001

• [Clinical-hemodynamic and anti-ischemic effects ivabradine and nebivolol ischemic heart disease with left ventricular dysfunction].

  Georgian medical news 20101001

• Nebivolol lowers blood pressure and increases weight loss in patients with hypertension and diabetes in regard to age.

  Journal of cardiovascular pharmacology 20100901

• Effectiveness of nebivolol and hydrochlorothiazide association on blood pressure, glucose, and lipid metabolism in hypertensive patients.

  Advances in therapy 20100901

• Efficacy of nebivolol and amitriptyline in the prophylaxis of cyclic vomiting syndrome: a case report.

  The neurologist 20100901

• Efficacy, tolerability and safety of nebivolol in patients with hypertension and diabetes: a post-marketing surveillance study.

  European review for medical and pharmacological sciences 20100901

• Skeletal muscle proteins oxidation in chronic right heart failure in rats: can different beta-blockers prevent it to the same degree?

  International journal of cardiology 20100820

• The role of carvedilol in the management of portal hypertension.

  European journal of gastroenterology & hepatology 20100801

• Nebivolol dilates human penile arteries and reverses erectile dysfunction in diabetic rats through enhancement of nitric oxide signaling.

  The journal of sexual medicine 20100801

• Comparison of the effects of nebivolol and valsartan on BP reduction and sleep apnoea activity in patients with essential hypertension and OSA.

  Current medical research and opinion 20100801

• Which beta-blocker is most effective in heart failure?

  Cardiovascular drugs and therapy 20100801

• Antihypertensive treatment with beta-blockers in the metabolic syndrome: a review.

  Current diabetes reviews 20100701

• Molecular dynamics simulations reveal fundamental role of water as factor determining affinity of binding of beta-blocker nebivolol to beta(2)-adrenergic receptor.

  The journal of physical chemistry. B 20100701

• Influence of diabetes mellitus and hyperglycemia on prognosis in patients > or =70 years old with heart failure and effects of nebivolol (data from the Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors with heart failure [SENIORS]).

  The American journal of cardiology 20100701

• The role of vasodilating beta-blockers in patients with complicated hypertension: focus on nebivolol.

  The American journal of medicine 20100701

• The role of nitric oxide in improving endothelial function and cardiovascular health: focus on nebivolol.

  The American journal of medicine 20100701

• One size does not fit all: the role of vasodilating beta-blockers in controlling hypertension as a means of reducing cardiovascular and stroke risk.

  The American journal of medicine 20100701

• [Nebivolol: the first vasodilatory beta-blocker with a beta3-adrenergic agonist activity].

  Annales de cardiologie et d'angeiologie 20100601

• Beneficial effects of nebivolol treatment on oxidative stress parameters in patients with slow coronary flow.

  Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20100601

• Lack of sinus rhythm predicts readmission, not Beta blockade.

  The American journal of cardiology 20100501

• Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats.

  Journal of hypertension 20100501

• Nebivolol/hydrochlorothiazide (HCTZ) combination in patients with essential hypertension: a pooled analysis from five non-interventional studies with a focus on diabetic and elderly patients.

  European review for medical and pharmacological sciences 20100501

• Nebivolol efficacy and safety in patients with stage I-II hypertension.

  Clinical cardiology 20100401

• Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat.

  Hypertension (Dallas, Tex. : 1979) 20100401

• Nebivolol in chronic heart failure: current evidence and future perspectives.

  Expert opinion on pharmacotherapy 20100401

• Nebivolol in the treatment of metabolic syndrome: making the fat more brownish.

  Medical hypotheses 20100301

• Nebivolol attenuates maladaptive proximal tubule remodeling in transgenic rats.

  American journal of nephrology 20100301

• The selective beta1-adrenoceptor antagonist nebivolol is a potential oestrogen receptor agonist with neuroprotective abilities.

  British journal of pharmacology 20100301

• Intentional overdose with cardiac arrest treated with intravenous fat emulsion and high-dose insulin.

  Clinical toxicology (Philadelphia, Pa.) 20100301

• Effects of nebivolol therapy on endothelial functions in cardiac syndrome X.

  Heart and vessels 20100301

• Effect of the long-term administration of nebivolol on clinical symptoms, exercise capacity and left ventricular function in patients with heart failure and preserved left ventricular ejection fraction: background, aims and design of the ELANDD study.

  Clinical research in cardiology : official journal of the German Cardiac Society 20100201

• Stability-Indicating TLC-densitometric determination of nebivolol hydrochloride in bulk and pharmaceutical dosage form.

  Journal of chromatographic science 20100201

• Nebivolol prevents remodeling in a rat myocardial infarction model: an echocardiographic study.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20100201

• Adding nebivolol to ongoing antihypertensive therapy improves blood pressure and response rates in patients with uncontrolled stage I-II hypertension.

  Journal of human hypertension 20100101

• Nebivolol improves renal function in patients who underwent angioplasty due to renal artery stenosis: a pilot study.

  Nephron. Clinical practice 20100101

• Nebivolol: haemodynamic effects and clinical significance of combined beta-blockade and nitric oxide release.

  Drugs 20100101

• Does nebivolol influence serum concentrations of proinflammatory cytokines in hypertensive (SHR) and normotensive (WKY) rats?

  Pharmacological reports : PR 20100101

• Clinical and economic aspects of the use of nebivolol in the treatment of elderly patients with heart failure.

  Clinical interventions in aging 20100101

• Sleep quality in patients with hypertension: additional negative effect of drug therapy.

  Sleep medicine 20091201

• Regional functions of the left ventricle in patients with coronary slow flow and the effects of nebivolol.

  Therapeutic advances in cardiovascular disease 20091201

• Neither K+ channels nor PI3K/Akt mediates the vasodilative effect of nebivolol on different types of rat arteries.

  Journal of cardiovascular pharmacology and therapeutics 20091201

• Nebivolol in high-risk, obese African Americans with stage 1 hypertension: effects on blood pressure, vascular compliance, and endothelial function.

  Journal of clinical hypertension (Greenwich, Conn.) 20091201

• The effect of nebivolol on atherogenesis in apoE-knockout mice.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20091201

• Proteomic profiling during atherosclerosis progression: Effect of nebivolol treatment.

  Molecular and cellular biochemistry 20091101

• Loss of arterial and renal nitric oxide bioavailability in hypertensive rats with diabetes: effect of beta-blockers.

  American journal of hypertension 20091101

• Nebivolol: the somewhat-different beta-adrenergic receptor blocker.

  Journal of the American College of Cardiology 20091013

• Nebivolol induces parallel improvement of left ventricular filling pressure and coronary flow reserve in uncomplicated arterial hypertension.

  Journal of hypertension 20091001

• Nebivolol reduces proteinuria and renal NADPH oxidase-generated reactive oxygen species in the transgenic Ren2 rat.

  American journal of nephrology 20091001

• Nebivolol therapy improves endothelial function and increases exercise tolerance in patients with cardiac syndrome X.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20091001

• Quality of life and efficacy of nebivolol in an open-label study in hypertensive patients. the QoLaN study.

  Blood pressure. Supplement 20091001

• Short-term treatment with a beta-blocker with vasodilative capacities improves intrarenal endothelial function in experimental renal failure.

  Life sciences 20090909

• Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial.

  European journal of heart failure 20090901

• Beta-blockers for hypertension: are they going out of style?

  Cleveland Clinic journal of medicine 20090901

• Efficacy of nebivolol on flow-mediated dilation in patients with slow coronary flow.

  International heart journal 20090901

• Efficacy and tolerability of nebivolol monotherapy by baseline systolic blood pressure: a retrospective analysis of pooled data from two multicenter, 12-week, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging studies in patients with mild to moderate essential hypertension.

  Clinical therapeutics 20090901

• Nitric oxide mechanisms of nebivolol.

  Therapeutic advances in cardiovascular disease 20090801

• Evolving mechanisms of action of beta blockers: focus on nebivolol.

  Journal of cardiovascular pharmacology 20090801

• Pulmonary effects of nebivolol.

  Therapeutic advances in cardiovascular disease 20090801

• The effects of nebivolol on P wave duration and dispersion in patients with coronary slow flow.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20090801

• Nebivolol in patients with coronary slow flow: the right drug for the right case?

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20090801

• What is the role, if any, for beta-blockers as initial therapy for uncomplicated hypertension?

  Current opinion in cardiology 20090701

• Realities of newer beta-blockers for the management of hypertension.

  Journal of clinical hypertension (Greenwich, Conn.) 20090701

• Beta-blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure).

  Journal of the American College of Cardiology 20090609

• Nebivolol in older adults with heart failure: reduced rates for seniors?

  Journal of the American College of Cardiology 20090609

• Nebivolol in obese and non-obese hypertensive patients.

  Journal of clinical hypertension (Greenwich, Conn.) 20090601

• Effect of nebivolol on blood oxygen transport indices and endothelial dysfunction in patients with arterial hypertension.

  Clinical physiology and functional imaging 20090501

• The effect of nebivolol treatment on oxidative stress and antioxidant status in patients with cardiac syndrome-X.

  Coronary artery disease 20090501

• Beta-blocker use and the development of depression.

  The American journal of cardiology 20090501

• An in-depth analysis of vasodilation in the management of hypertension: focus on adrenergic blockade.

  Journal of cardiovascular pharmacology 20090501

• Nebivolol, a vasodilating selective beta(1)-blocker, is a beta(3)-adrenoceptor agonist in the nonfailing transplanted human heart.

  Journal of the American College of Cardiology 20090428

• beta(3)-Adrenoceptor stimulation on top of beta(1)-adrenoceptor blockade 'Stop or Encore?'.

  Journal of the American College of Cardiology 20090428

• The anti-inflammatory effects of nebivolol in human coronary smooth muscle cells: clinical implications.

  International journal of cardiology 20090417

• Rationale and design of a trial evaluating the effects of losartan vs. nebivolol vs. the association of both on the progression of aortic root dilation in Marfan syndrome with FBN1 gene mutations.

  Journal of cardiovascular medicine (Hagerstown, Md.) 20090401

• New drug update: 2008.

  The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20090401

• Nebivolol decreases endothelial cell stiffness via the estrogen receptor beta: a nano-imaging study.

  Journal of hypertension 20090301

• Nebivolol: a third-generation beta-blocker for hypertension.

  Clinical therapeutics 20090301

• Drug approvals: '08 in review. Nebivolol (Bystolic).

  The Nurse practitioner 20090201

• Investigation of the different adrenoceptor targets of nebivolol enantiomers in rat thoracic aorta.

  British journal of pharmacology 20090201

• Heart rate variability in rats with experimental chronic heart failure and long-term exposure to beta-adrenoblockers.

  Bulletin of experimental biology and medicine 20090201

• Comparison of Nebivolol monotherapy versus Nebivolol in combination with other antihypertensive therapies for the treatment of hypertension.

  The American journal of cardiology 20090115

• Load-induced cardiomyocyte apoptosis in cultured multicellular myocardial preparations is unaltered in presence of the beta-adrenoceptor antagonist nebivolol.

  Pharmacology 20090101

• [Third generation beta-blockers: current state of research on vasodilating beta-blockers].

  Wiener medizinische Wochenschrift (1946) 20090101

• Arterial stiffness, hypertension, and rational use of nebivolol.

  Vascular health and risk management 20090101

• Nebivolol: in the treatment of hypertension in the US.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101

• The effect of beta-blockers on the adaptive immune system in chronic heart failure.

  Cardiovascular therapeutics 20090101

• Could nebivolol be an alternative drug for the treatment of diabetic foot ulcers?

  Journal of the American Podiatric Medical Association 20090101

• Reduced intimal hyperplasia in rabbits via medical therapy after carotid venous bypass.

  Texas Heart Institute journal 20090101

• Validation and application of high-performance liquid chromatographic and spectrophotometric methods for simultaneous estimation of nebivolol and hydrochlorothiazide: a novel approach to multivariate calibrations by R-Software Environment.

  Journal of AOAC International 20090101

• [Optimization of use of beta-adrenoblockers in the treatment of chronic heart failure in the outpatient setting].

  Terapevticheskii arkhiv 20090101

• [Correction of portal hypertension and renal dysfunction with help of nebivolol and lizinopril in patients with hepatic cirrhosis].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101

• [Optimization of the treatment of patients with chronic cardiac insufficiency and cardiopulmonary pathology].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

• Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients.

  American journal of hypertension 20081101

• Impact of beta-blockers on sleep in patients with mild hypertension: a randomized trial between nebivolol and metoprolol.

  Advances in therapy 20080901

• Pharmacological approaches to improve endothelial repair mechanisms.

  Expert review of cardiovascular therapy 20080901

• Therapeutic dose of nebivolol, a nitric oxide-releasing beta-blocker, reduces atherosclerosis in cholesterol-fed rabbits.

  Nitric oxide : biology and chemistry 20080801

• Pharmacologic considerations in the positioning of beta-blockers in antihypertensive therapy.

  Current hypertension reports 20080801

• Effects of the vasodilating beta-blocker nebivolol on smoking-induced endothelial dysfunction in young healthy volunteers.

  Vascular health and risk management 20080801

• Nebivolol: a new antihypertensive agent.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080615

• Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein e-knockout mice.

  The Journal of pharmacology and experimental therapeutics 20080601

• Beta-blockers reduce aortic stiffness in hypertension but nebivolol, not atenolol, reduces wave reflection.

  American journal of hypertension 20080601

• Protective effects of nebivolol on oxygen free radical-induced vasoconstrictions in vitro.

  Medical science monitor : international medical journal of experimental and clinical research 20080601

• Differential effects of nebivolol and atenolol on transmitral diastolic filling parameters in patients with essential hypertension.

  Advances in therapy 20080601

• Nebivolol (Bystolic): overview of a third generation beta-blocker.

  South Dakota medicine : the journal of the South Dakota State Medical Association 20080601

• Effects of the systemic beta-adrenoceptor antagonist nebivolol on ocular hemodynamics in glaucoma patients.

  Medical science monitor : international medical journal of experimental and clinical research 20080501

• Treatment of heart failure with preserved systolic function.

  Archives of cardiovascular diseases 20080501

• The effects of nebivolol on apoptosis in a rat infarct model.

  Circulation journal : official journal of the Japanese Circulation Society 20080401

• Beta-blockers in the management of hypertension: focus on nebivolol.

  Expert review of cardiovascular therapy 20080401

• Major differences in gene expression in human coronary smooth muscle cells after nebivolol or metoprolol treatment.

  International journal of cardiology 20080328

• Nebivolol (Bystolic) for hypertension.

  The Medical letter on drugs and therapeutics 20080310

• Preventive effect of nebivolol on contrast-induced nephropathy in rats.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080301

• Beta-blockers in the treatment of hypertension: new data, new directions.

  Journal of clinical hypertension (Greenwich, Conn.) 20080301

• Stereochemical comparison of nebivolol with other beta-blockers.

  Chirality 20080201

• Nebivolol: pharmacologic profile of an ultraselective, vasodilatory beta1-blocker.

  Journal of clinical pharmacology 20080201

• A comparison of atenolol and nebivolol in isolated systolic hypertension.

  Journal of hypertension 20080201

• Prominent cardioprotective effects of third generation beta blocker nebivolol against anthracycline-induced cardiotoxicity using the model of isolated perfused rat heart.

  European journal of cancer (Oxford, England : 1990) 20080201

• New beta-blocker gets FDA approval.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080201

• Effect of nebivolol and metoprolol treatments on serum asymmetric dimethlyarginine levels in hypertensive patients with type 2 diabetes mellitus.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20080201

• Use of nebivolol for the treatment of endothelial dysfunction in patients with hypertension: the EDEN registry.

  Journal of cardiovascular pharmacology 20080201

• Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptors.

  Pharmacology 20080101

• Nebivolol and metoprolol for treating migraine: an advance on beta-blocker treatment?

  Headache 20080101

• Efficacy and tolerability of nebivolol compared with other antihypertensive drugs: a meta-analysis.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20080101

• New drugs: nebivolol hydrochloride, nilotinib, and sapropterin dihydrochloride.

  Journal of the American Pharmacists Association : JAPhA 20080101

• Effects of nebivolol on endothelial gene expression during oxidative stress in human umbilical vein endothelial cells.

  Mediators of inflammation 20080101

• Nebivolol: a new third-generation beta-blocker agent: implications for Clinical Nurse Specialist Practice.

  Clinical nurse specialist CNS 20080101

• [Comparison of effects of nebivolol and atenolol on P-wave dispersion in patients with hypertension].

  Kardiologiia 20080101

• Collaborative therapy with nebivalol and L-NAME for spinal cord ischemia/reperfusion injury.

  Annals of vascular surgery 20080101

• Determination of nebivolol and valsartan in a fixed-dose combination by liquid chromatography.

  Journal of AOAC International 20080101

• Different pharmacological properties of two enantiomers in a unique beta-blocker, nebivolol.

  Cardiovascular therapeutics 20080101

• [Endothelioprotective properties of L-arginine in a nitric oxide deficiency model].

  Eksperimental'naia i klinicheskaia farmakologiia 20080101

• Development and validation of a stability-indicating column high-performance liquid chromatographic assay method for determination of nebivolol in tablet formulation.

  Journal of AOAC International 20080101

• Early effects of treatment with nebivolol and quinapril on endothelial function in patients with hypertension.

  Endothelium : journal of endothelial cell research 20080101

• Impact of nebivolol on levels of serum nitric oxide, plasma von Willebrand factor and exercise stress testing parameters in hypertensive and ischemic heart disease patients.

  Cardiology journal 20080101

• Nebivolol: a highly selective beta1-adrenergic receptor blocker that causes vasodilation by increasing nitric oxide.

  Cardiovascular therapeutics 20080101

• [Heart rate variability dynamics during treatment of arterial hypertension].

  Kardiologiia 20080101

• Long-term cost-effectiveness analysis of nebivolol compared with standard care in elderly patients with heart failure: an individual patient-based simulation model.

  PharmacoEconomics 20080101

• Nebivolol reduces experimentally induced warm renal ischemia reperfusion injury in rats.

  Renal failure 20080101

• Determination of nebivolol hydrochloride and hydrochlorothiazide in tablets by first-order derivative spectrophotometry and liquid chromatography.

  Journal of AOAC International 20080101

• Signalling transduction pathways implicated in Nebivolol-induced NO production in endothelial cells.

  Bio-medical materials and engineering 20080101

• [Efficacy of lisinopril and nebivolol therapy of portal hypertension and kidney dysfunction in patients with liver cirrhosis].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20080101

• [Clinico-immunological disorders in patients with ischemic heart disease combined with metabolic syndrome and modulating effect of nebivolol for their correction].

  Terapevticheskii arkhiv 20080101

• [Clinical efficacy of ivabradin and nebivolol addition in combined treatment of ischemic heart disease patients with left ventricular dysfunction].

  Terapevticheskii arkhiv 20080101

• Nebivolol reduces asymmetric dimethylarginine in endothelial cells by increasing dimethylarginine dimethylaminohydrolase 2 (DDAH2) expression and activity.

  Pharmacological research 20071201

• Long-term nebivolol administration reduces renal fibrosis and prevents endothelial dysfunction in rats with hypertension induced by renal mass reduction.

  Journal of hypertension 20071201

• Effect of nebivolol and metoprolol treatments on serum asymmetric dimethylarginine levels in hypertensive patients with type 2 diabetes mellitus.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20071201

• Does nebivolol improve endothelial dysfunction and will it rescue the reputation of the beta-blockers in the future?

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20071201

• A review of the safety and efficacy of nebivolol in the mildly hypertensive patient.

  Vascular health and risk management 20071201

• The efficacy and tolerability of nebivolol in hypertensive African American patients.

  Journal of clinical hypertension (Greenwich, Conn.) 20071101

• Simultaneous determination of fixed dose combination of nebivolol and valsartan in human plasma by liquid chromatographic-tandem mass spectrometry and its application to pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015

• Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation.

  Hypertension (Dallas, Tex. : 1979) 20071001

• Nebivolol in the treatment of chronic heart failure.

  Vascular health and risk management 20071001

• Protective effects of nebivolol and reversal of endothelial dysfunction in diabetes associated with hypertension.

  European journal of pharmacology 20070910

• A randomized, double-blind, placebo-controlled parallel-group study to assess the efficacy and safety of nebivolol, a novel beta-blocker, in patients with mild to moderate hypertension.

  Journal of clinical hypertension (Greenwich, Conn.) 20070901

• The vasodilatory beta-blockers.

  Current hypertension reports 20070801

• The editor's roundtable: revisiting the role of beta blockers in hypertension.

  The American journal of cardiology 20070715

• Tolerability and dose-related effects of nebivolol in elderly patients with heart failure: data from the Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with Heart Failure (SENIORS) trial.

  American heart journal 20070701

• Nebivolol: third-generation beta-blockade.

  Expert opinion on pharmacotherapy 20070701

• Vasodilator effects of nebivolol in a rat model of hypertension and a rabbit model of congestive heart failure.

  Journal of cardiovascular pharmacology 20070701

• A validated UV spectrophotometric method for estimation of nebivolol hydrochloride in bulk and pharmaceutical formulation.

  Die Pharmazie 20070701

• Nebivolol induces eNOS activation and NO-liberation in murine corpus cavernosum.

  Life sciences 20070606

• The effects of nebivolol on fibrinolytic parameters in mild and moderate hypertensive patients.

  The Canadian journal of cardiology 20070601

• Pharmacological augmentation of endothelium-derived nitric oxide synthesis.

  Journal of managed care pharmacy : JMCP 20070601

• Case study: the link between hypertension and diabetes.

  Journal of managed care pharmacy : JMCP 20070601

• Pharmacoeconomic benefits of antihypertensive therapy.

  Journal of managed care pharmacy : JMCP 20070601

• Nebivolol: more than a highly selective Beta blocker.

  Recent patents on cardiovascular drug discovery 20070601

• The influence of CYP2D6 phenotype on the clinical response of nebivolol in patients with essential hypertension.

  British journal of clinical pharmacology 20070501

• Evidence for an estradiol-agonistic action of nebivolol in spontaneously hypertensive rats.

  Journal of hypertension 20070501

• Nebivolol for heart failure in the elderly.

  Expert review of cardiovascular therapy 20070501

• EVOLVE (nebivolol evaluation for efficacy and safety in the treatment of hypertension) postmarketing surveillance study.

  Journal of the Indian Medical Association 20070501

• Does the beta-blocker nebivolol increase coronary flow reserve?

  Cardiovascular drugs and therapy 20070401

• Effect of DL-nebivolol, its enantiomers and metabolites on the intracellular production of superoxide and nitric oxide in human endothelial cells.

  Pharmacological research 20070401

• Nitric oxide, erectile dysfunction and beta-blocker treatment (MR NOED study): benefit of nebivolol versus metoprolol in hypertensive men.

  Clinical and experimental pharmacology & physiology 20070401

• Unique effect of nebivolol on coronary hemodynamics: it's all a matter of flow.

  Cardiovascular drugs and therapy 20070401

• Effects of nebivolol on platelet activation in hypertensive patients: a comparative study with metoprolol.

  International journal of cardiology 20070320

• Nebivolol improves coronary flow reserve in patients with idiopathic dilated cardiomyopathy.

  Heart (British Cardiac Society) 20070301

• Acute hemodynamic effects of moderate doses of nebivolol versus metoprolol in patients with systolic heart failure.

  International journal of clinical pharmacology and therapeutics 20070201

• The Influence of prolonged beta-blockers treatment on male rabbit's sexual behavior and penile microcirculation.

  International journal of impotence research 20070101

• Metabolic effects of beta-blockers: importance of dissociating newer from conventional agents.

  Journal of hypertension 20070101

• Influence of nebivolol and metoprolol on inflammatory mediators in human coronary endothelial or smooth muscle cells. Effects on neointima formation after balloon denudation in carotid arteries of rats treated with nebivolol.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• [Effect of nebivolol on the blood oxygen transport].

  Eksperimental'naia i klinicheskaia farmakologiia 20070101

• Metabolic profile of nebivolol, a beta-adrenoceptor antagonist with unique characteristics.

  Drugs 20070101

• [Correction of primary hemostasis in patients suffering from arterial hypertension with metabolic syndrome].

  Klinicheskaia meditsina 20070101

• [Pulse pressure, arterial compliance and Buckberg index in hypertensive patients treated with nebivolol and nitrates].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20070101

• Blood pressure-lowering effect of nebivolol in hypertensive patients with type 2 diabetes mellitus: the YESTONO study.

  Clinical drug investigation 20070101

• [Administration of cardioselective beta-adrenoblockers in patients with arterial hypertension and/or ischemic heart disease associated with bronchoobstructive syndrome].

  Terapevticheskii arkhiv 20070101

• Comparative effects of conventional B-blockers and nebivolol on psychomotor performances in healthy volunteers: a preliminary report.

  Indian journal of physiology and pharmacology 20070101

• [Effects of a superselective beta1-adrenoblocker nebivolol on the course of coronary heart disease and insulin resistance in patients with diabetes mellitus type 2 after coronary artery bypass grafting].

  Terapevticheskii arkhiv 20070101

• [Level of hormones of pituitary-gonadal axis, penile blood flow and sexual function in men with arterial hypertension during monotherapy with bisoprolol and nebivolol].

  Kardiologiia 20070101

• [Influence of nebivolol on left ventricular remodeling in patients with arterial hypertension without chronic heart failure].

  Kardiologiia 20070101

• In vivo and in vitro effects of nebivolol on penile structures in hypertensive rats.

  American journal of hypertension 20061201

• Targeting nitric oxide with drug therapy.

  Journal of clinical hypertension (Greenwich, Conn.) 20061201

• [Role of the L-arginine/nitric oxide system in the action of nebivolol].

  Deutsche medizinische Wochenschrift (1946) 20061110

• Different effects of atenolol and nebivolol on coronary flow reserve.

  Heart (British Cardiac Society) 20061101

• Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats.

  Hypertension (Dallas, Tex. : 1979) 20061001

• New drugs for hypertension: what do they offer?

  Current hypertension reports 20061001

• Lichenoid eruption associated with the use of nebivolol.

  The Annals of pharmacotherapy 20060901

• Nebivolol: a novel beta-blocker with nitric oxide-induced vasodilatation.

  Vascular health and risk management 20060901

• ENOS is not activated by nebivolol in human failing myocardium.

  Life sciences 20060822

• Management of global risk across the continuum of hypertensive heart disease.

  Journal of clinical hypertension (Greenwich, Conn.) 20060801

• Mechanisms underlying nebivolol-induced endothelial nitric oxide synthase activation in human umbilical vein endothelial cells.

  Clinical and experimental pharmacology & physiology 20060801

• Nebivolol: a review of its clinical and pharmacological characteristics.

  International journal of clinical pharmacology and therapeutics 20060801

• Influence of nebivolol and enalapril on metabolic parameters and arterial stiffness in hypertensive type 2 diabetic patients.

  Journal of hypertension 20060701

• Effect of nebivolol on endothelial nitric oxide and peroxynitrite release in hypertensive animals: Role of antioxidant activity.

  Journal of cardiovascular pharmacology 20060701

• Radical scavenging and NO-releasing properties of selected beta-adrenoreceptor antagonists.

  Free radical research 20060701

• Characterization of nitric oxide release by nebivolol and its metabolites.

  American journal of hypertension 20060601

• [Effect of nebivolol on endothelial function in obese patients with hypertension].

  Likars'ka sprava 20060601

• [Effects of nebivolol on endothelial dysfunction in patients with diastolic dysfunction of left ventricle].

  Georgian medical news 20060501

• Mixed beta3-adrenoceptor agonist and alpha1-adrenoceptor antagonist properties of nebivolol in rat thoracic aorta.

  British journal of pharmacology 20060401

• Effect of treatment with nebivolol on parameters of oxidative stress in type 2 diabetics with mild to moderate hypertension.

  Journal of clinical pharmacy and therapeutics 20060401

• Influence of nebivolol on endothelial dysfunction in salt-sensitive hypertension.

  Georgian medical news 20060401

• Effects of nebivolol in elderly heart failure patients with or without systolic left ventricular dysfunction: results of the SENIORS echocardiographic substudy.

  European heart journal 20060301

• Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients.

  Journal of hypertension 20060301

• Beneficial effects of switching from beta-blockers to nebivolol on the erectile function of hypertensive patients.

  Asian journal of andrology 20060301

• Phosphodiesterase type 5 inhibitor sildenafil citrate does not potentiate the vasodilative properties of nebivolol in rat aorta.

  Life sciences 20060202

• Cardiovascular effects of nebivolol in spontaneously hypertensive rats persist after treatment withdrawal.

  Journal of hypertension 20060101

• Beta-adrenoceptor antagonists in elderly patients with chronic heart failure: therapeutic potential of third-generation agents.

  Drugs & aging 20060101

• Comparing beta-blocking effects of bisoprolol, carvedilol and nebivolol.

  Cardiology 20060101

• [Effect of nitrogen oxide donor and inhibitor on some biochemical indices of the brain of intact rats and rats with subarachnoidal hemorrages].

  Likars'ka sprava 20060101

• SENIORS study using nebivolol provides best evidence of effective treatment for heart failure in the elderly.

  Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20060101

• Nationwide efficacy-safety study of nebivolol in mildly hypertensive patients.

  American journal of therapeutics 20060101

• Nebivolol: a third-generation beta-adrenergic blocker.

  The Annals of pharmacotherapy 20060101

• Gender dependency of circadian blood pressure and heart rate profiles in spontaneously hypertensive rats: effects of beta-blockers.

  Chronobiology international 20060101

• Nebivolol: a review of its use in the management of hypertension and chronic heart failure.

  Drugs 20060101

• Effects of nebivolol versus carvedilol on left ventricular function in patients with chronic heart failure and reduced left ventricular systolic function.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101

• Nebivolol: new therapy update.

  Cardiology in review 20060101

• [Cardioselective beta-adrenoblockers in patients with stable angina pectoris. Comparison of efficacy and safety].

  Terapevticheskii arkhiv 20060101

• [Special features of pathogenesis and pharmacotherapy of chronic heart failure in women].

  Kardiologiia 20060101

• [Nebivolol effects on the cardiovascular system and the kidneys in pregnant and puerperal women with hypertension].

  Terapevticheskii arkhiv 20060101

• Nebivovol and carvedilol induce NO-dependent coronary vasodilatation that is unlikely to be mediated by extracellular ATP in the isolated guinea pig heart.

  Pharmacological reports : PR 20060101

• [Estimation of the protective effect of Nebilet for perioperative cardiac complications in patients underwent vascular surgery: results of prospective study].

  Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20060101

• Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black Americans.

  Circulation 20051213

• The role of beta-blockers as a cornerstone of cardiovascular therapy.

  American journal of hypertension 20051201

• The role of the new beta-blockers in treating cardiovascular disease.

  American journal of hypertension 20051201

• Exploring vascular benefits of endothelium-derived nitric oxide.

  American journal of hypertension 20051201

• Effect of nebivolol on cardiovascular changes associated with a rat model of insulin-resistance.

  Cellular and molecular biology (Noisy-le-Grand, France) 20051108

• Comparative efficacy of nebivolol versus carvedilol on left ventricular function and exercise capacity in patients with nonischemic dilated cardiomyopathy. A 12-month study.

  American heart journal 20051101

• Rapid quantification of nebivolol in human plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20051004

• Endothelial beta3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta-blocker nebivolol.

  Circulation 20050823

• Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: putting guidelines into practice.

  European journal of heart failure 20050801

• Effect of nebivolol and atenolol on brachial artery flow-mediated vasodilation in patients with coronary artery disease.

  Cardiovascular drugs and therapy 20050801

• Quality of life and antihypertensive effect with nebivolol and losartan.

  American journal of hypertension 20050801

• Effects of nebivolol on left ventricular function in elderly patients with chronic heart failure: results of the ENECA study.

  European journal of heart failure 20050601

• Involvement of nitric oxide in both central and peripheral haemodynamic effect of D/L-nebivolol and its enantiomers in rats.

  European journal of pharmacology 20050328

• Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation.

  Journal of hypertension 20050301

• Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS).

  European heart journal 20050201

• Making sense of SENIORS.

  European heart journal 20050201

• Left ventricular mass and mechanics in mild-to-moderate hypertension: effect of nebivolol versus telmisartan.

  American journal of hypertension 20050201

• Effects of nebivolol on artery hypertension--multicentre study Bosnia and Herzegovina.

  Bosnian journal of basic medical sciences 20050201

• The cellular mechanisms involved in the vasodilator effect of nebivolol on the renal artery.

  European journal of pharmacology 20050131

• Effect of nebivolol on QT dispersion in hypertensive patients with left ventricular hypertrophy.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20050101

• [The influence of nebivolol on thrombocyte aggregation in patients with arterial hypertension with metabolic sydrome].

  Klinicheskaia meditsina 20050101

• [Antiischemic and metabolic effects of nebivolol and metaprolol CR/XL (betalok ZOK) in patients with postinfarction heart dysfunction].

  Klinicheskaia meditsina 20050101

• Effects of Nebivolol on left ventricular function and exercise capacity in patients with non-ischaemic dilated cardiomyopathy. A randomised placebo-controlled study.

  Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20050101

• Clinical use of Nebivolol in the treatment of chronic heart failure.

  Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20050101

• [Clinical and prognostic value of therapy with contemporary beta-adrenoblockers in patients after myocardial infarction].

  Kardiologiia 20050101

• [Cardiorenal pathology in diabetes mellitus type 1: mechanisms of development and medical correction].

  Terapevticheskii arkhiv 20050101

• Economic evaluation of nebivolol in the treatment of hypertension.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

• [Short-term effect of nebivolol on the left ventricular diastolic function].

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20041201

• Nebivolol improves coronary flow reserve in hypertensive patients without coronary heart disease.

  Journal of hypertension 20041101

• The protective effect of nebivolol on ischemia/reperfusion injury in rabbit spinal cord.

  Progress in neuro-psychopharmacology & biological psychiatry 20041101

• Autonomic effects of nebivolol versus atenolol in healthy subjects.

  Cardiovascular drugs and therapy 20041101

• Clinical trials update from the European Society of Cardiology: SENIORS, ACES, PROVE-IT, ACTION, and the HF-ACTION trial.

  European journal of heart failure 20041001

• Experimental evidences of nitric oxide-dependent vasodilatory activity of nebivolol, a third-generation beta-blocker.

  Blood pressure. Supplement 20041001

• Clinical pharmacodynamics of nebivolol: new evidence of nitric oxide-mediated vasodilating activity and peculiar haemodynamic properties in hypertensive patients.

  Blood pressure. Supplement 20041001

• Nebivolol increases arterial distensibility in vivo.

  Hypertension (Dallas, Tex. : 1979) 20040901

• The impact of third-generation beta-blocker antihypertensive treatment on endothelial function and the prothrombotic state: effects of smoking.

  American journal of hypertension 20040701

• Estrogen receptor-mediated vascular responsiveness to nebivolol: a novel endothelium-related mechanism of therapeutic vasorelaxation.

  Journal of cardiovascular pharmacology 20040501

• [Genetic polymorphisms in drug metabolizing enzymes--impact on treatment with beta-blockers].

  Deutsche medizinische Wochenschrift (1946) 20040408

• Nebivolol: a review.

  Expert opinion on pharmacotherapy 20040401

• [Beta blocker activates release of NO. Radical against atherosclerosis].

  MMW Fortschritte der Medizin 20040311

• Different effects of exercise on plasma concentrations of nebivolol, bisoprolol and carvedilol.

  Cardiovascular drugs and therapy 20040301

• Antioxidant activity of nebivolol in the rat aorta.

  Journal of cardiovascular pharmacology 20040101

• [Nebivolol in the treatment of ischemic heart disease patients with chronic heart failure].

  Kardiologiia 20040101

• Comparative effects of a two-week treatment with nebivolol and nifedipine in hypertensive patients suffering from COPD.

  Respiration; international review of thoracic diseases 20040101

• [The use of nebivolol for the treatment of hypertension in patients with osteoarthrosis].

  Kardiologiia 20040101

• [Antiremodeling Activity of Nebivolol in Patients With Essential Hypertension and Various Types of 4a/4b Polymorphisms of Endothelial NO Synthase Gene].

  Kardiologiia 20040101

• [Experience with the superselective third-generation beta-adrenoblocker nebivolol used to treat patients with prior myocardial infarction].

  Klinicheskaia meditsina 20040101

• Pharmacological mechanisms of clinically favorable properties of a selective beta1-adrenoceptor antagonist, nebivolol.

  Cardiovascular drug reviews 20040101

• [Treatment of pulmonary hypertension in COPD: is there hope for the better?].

  Pneumologia (Bucharest, Romania) 20040101

• [Beta blocker improves the endothelial function. Gas-forming blood vessel protection].

  MMW Fortschritte der Medizin 20031218

• Efficacy and tolerability profile of nebivolol vs atenolol in mild-to-moderate essential hypertension: results of a double-blind randomized multicentre trial.

  Blood pressure. Supplement 20031201

• Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation.

  Journal of the American College of Cardiology 20031119

• [Beta-1 blockade plus NO release. Additional organ protection for patients with hypertension].

  MMW Fortschritte der Medizin 20031002

• Beta-blocker treatment of patients with diastolic heart failure and arterial hypertension. A prospective, randomized, comparison of the long-term effects of atenolol vs. nebivolol.

  European journal of heart failure 20031001

• Long-term treatment with nebivolol improves arterial reactivity and reduces ventricular hypertrophy in spontaneously hypertensive rats.

  Journal of cardiovascular pharmacology 20030901

• Lack of inverse agonistic activity of nebivolol, its D- and L-enantiomers and of in vivo metabolized nebivolol in human myocardium.

  European journal of pharmacology 20030822

• Involvement of the beta3 adrenoceptor in nebivolol-induced vasorelaxation in the rat aorta.

  Journal of cardiovascular pharmacology 20030801

• Comparison of effects on systolic and diastolic left ventricular function of nebivolol versus atenolol in patients with uncomplicated essential hypertension.

  The American journal of cardiology 20030801

• Third-generation beta-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: a novel mechanism for antihypertensive action.

  Circulation 20030603

• A comparison of the beta1-selectivity of three beta1-selective beta-blockers.

  Journal of clinical pharmacy and therapeutics 20030601

• The combination of nebivolol plus pravastatin is associated with a more beneficial metabolic profile compared to that of atenolol plus pravastatin in hypertensive patients with dyslipidemia: a pilot study.

  Journal of cardiovascular pharmacology and therapeutics 20030601

• [Initial data on nebivolol in heart failure. Beta blockers strengthen older hearts, too].

  MMW Fortschritte der Medizin 20030529

• Effects of nebivolol on ischemia-induced metabolic changes in dog hearts.

  Journal of cardiovascular pharmacology 20030501

• Evaluation of the efficacy and tolerability of nebivolol versus lisinopril in the treatment of essential arterial hypertension: a randomized, multicentre, double-blind study.

  Blood pressure. Supplement 20030501

• Comparison of the new cardioselective beta-blocker nebivolol with bisoprolol in hypertension: the Nebivolol, Bisoprolol Multicenter Study (NEBIS).

  Cardiovascular drugs and therapy 20030501

• Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritis.

  Journal of hypertension 20030401

• Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells.

  Arteriosclerosis, thrombosis, and vascular biology 20030401

• [Hemodynamic effects of the beta blocker nebivolol].

  Der Internist 20030401

• Beta 1-adrenoceptor selectivity of nebivolol and bisoprolol. A comparison of [3H]CGP 12.177 and [125I]iodocyanopindolol binding studies.

  European journal of pharmacology 20030126

• [Influence of the beta-blocker nebivolol on left ventricular function in patients with chronic heart failure].

  Medizinische Klinik (Munich, Germany : 1983) 20030115

• Effect of forced titration of nebivolol on response rate in obese hypertensive patients.

  American journal of hypertension 20030101

• [Use of nebivolol in patients with mild and moderate hypertension].

  Terapevticheskii arkhiv 20030101

• [Clinical and metabolic effects of cardioselective beta-adrenoblockers nebivolol and metoprolol in patients with hypertension and ischemic heart disease associated with type 2 diabetes].

  Kardiologiia 20030101

• [Effect of nebivolol on the state of pituitary-gonadal system and lipid peroxidation in young and middle aged men with hypertension].

  Kardiologiia 20030101

• [Pharmacological modulation of NO synthesis in patients with arterial hypertension and endothelial dysfunction].

  Klinicheskaia meditsina 20030101

• [Dynamics of a 24-h profile of arterial pressure and function of the vascular endothelium in nebivolol treatment of hypertensive patients].

  Klinicheskaia meditsina 20030101

• [The use of nebivolol in menopausal women with hypertension].

  Kardiologiia 20030101

• [Heart rate control with nebivolol in patients with tachysystolic atrial fibrillation].

  Kardiologiia 20030101

• [Nebivolol effects on platelet aggregation and anticoagulation system].

  Kardiologiia 20030101

• [Endothelial dysfunction and metabolic effects of nitric oxide in human].

  Fiziologiia cheloveka 20030101

• [Beta blocker enhances NO liberation in the endothelium. Vascular tone long-term improvement].

  MMW Fortschritte der Medizin 20021205

• Effect of nebivolol on left ventricular function in patients with chronic heart failure: a pilot study.

  European journal of heart failure 20021201

• No-dependent vasodilation induced by nebivolol in coronary circulation is not mediated by beta-adrenoceptors or by 5 HT1A-receptors.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201

• Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with Heart Failure (SENIORS). Rationale and design.

  International journal of cardiology 20021101

• [Beta blockade plus NO release. Patients with heart failure can be loaded more].

  MMW Fortschritte der Medizin 20021010

• Allergic contact dermatitis to nebivolol.

  Allergy 20020901

• Focus on small artery stiffness.

  Journal of hypertension 20020901

• Effects of nebivolol and atenolol on small arteries and microcirculatory endothelium-dependent dilation in hypertensive patients undergoing isometric stress.

  Journal of hypertension 20020901

• Nebivolol: a selective beta(1)-adrenergic receptor antagonist that relaxes vascular smooth muscle by nitric oxide- and cyclic GMP-dependent mechanisms.

  Nitric oxide : biology and chemistry 20020901

• Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMP.

  Nitric oxide : biology and chemistry 20020901

• [Beta blocker in endothelial dysfunction. Growth of blood vessel cells is halted].

  MMW Fortschritte der Medizin 20020822

• [Cardiac protection by beta-1 selective beta blocker. Still better in the 3rd generation?].

  MMW Fortschritte der Medizin 20020711

• [Despite antihypertensive treatment with beta-blocker patients remain incapacitated].

  MMW Fortschritte der Medizin 20020502

• Paradoxical pressor effects of beta-blockers in standing elderly patients with mild hypertension: a beneficial side effect.

  Circulation 20020409

• Bucindolol exerts agonistic activity on the propranolol-insensitive state of beta1-adrenoceptors in human myocardium.

  The Journal of pharmacology and experimental therapeutics 20020301

• Nebivolol and endothelium dysfunction in salt-sensitive Dahl rats.

  Journal of hypertension 20020301

• Nitric-oxide-mediated relaxations in salt-induced hypertension: effect of chronic beta1 -selective receptor blockade.

  Journal of hypertension 20020301

• Hyperkalaemia in an elderly diabetic patient.

  Postgraduate medical journal 20020101

• [Effects of nebivolol on serum levels of NO2 and NO3 oxides in patients with type 2 diabetes mellitus].

  Likars'ka sprava 20020101

• Nebivolol vs amlodipine as first-line treatment of essential arterial hypertension in the elderly.

  Blood pressure 20020101

• [Antihypertensive efficacy and tolerability of nebivolol].

  Kardiologiia 20020101

• [Assessment of safety and antihypertensive efficacy of a cardioselective beta-blocker nebivolol in patients with hypertension and concomitant chronic obstructive bronchitis].

  Kardiologiia 20020101

• [Effect of nebivolol on remodeling of the heart and vessels and the state of hemodynamics in patients with hypertension].

  Kardiologiia 20020101

• [Effect of nebivolol on dynamics of microalbuminuria, renal blood flow and 24-hour blood pressure profile in patients with hypertension].

  Kardiologiia 20020101

• [Experience of the use of nebivolol in the treatment of hypertension in postmenopausal women].

  Kardiologiia 20020101

• [Effects of nebivolol on microcirculation, platelet aggregation and blood viscosity in patients with essential hypertension].

  Kardiologiia 20020101

• [Assessment of efficacy and safety of nebivolol in patients with stable effort angina].

  Kardiologiia 20020101

• [Functional and biochemical characteristics of the vasodilator effects of nebivolol in patients with arterial hypertension].

  Terapevticheskii arkhiv 20020101

• [Effect of enape combined with nebilet in hypertension].

  Likars'ka sprava 20020101

• [Effect of nebivolol on the level of constitutional, inducible, and total NO-synthase in serum of patients with type II diabetes mellitus].

  Likars'ka sprava 20020101

• Nebivolol ameliorates nitric oxide deficient hypertension.

  TheScientificWorldJournal 20020101

• Effects of nebivolol on human platelet aggregation.

  Journal of cardiovascular pharmacology 20011201

• Nebivolol: endothelium-mediated vasodilating effect.

  Journal of cardiovascular pharmacology 20011201

• Protective role of nebivolol in hydroxyl radical induced injury.

  Journal of cardiovascular pharmacology 20011201

• Beta-blockade in hypertension and congestive heart failure.

  Journal of cardiovascular pharmacology 20011201

• Vascular effects of newer cardiovascular drugs: focus on nebivolol and ACE-inhibitors.

  Journal of cardiovascular pharmacology 20011201

• Metabolic effects and safety profile of nebivolol.

  Journal of cardiovascular pharmacology 20011201

• [Beta blockers in heart failure administered with too much reticence. Longevity sacrificed].

  MMW Fortschritte der Medizin 20011129

• Endothelial adrenoceptors.

  Journal of cardiovascular pharmacology 20011101

• [Pharma-clinics medication of the month. Nebivolol (Nobiten)].

  Revue medicale de Liege 20011101

• Integrated effects of the vasodilating beta-blocker nebivolol on exercise performance, energy metabolism, cardiovascular and neurohormonal parameters in physically active patients with arterial hypertension.

  Journal of human hypertension 20011001

• [Nebivolol (nebilet) a beta blocker of the third generation--also for patients with obstructive lung diseases?].

  Zeitschrift fur Kardiologie 20011001

• Nebivolol induces calcium-independent signaling in endothelial cells by a possible beta-adrenergic pathway.

  Journal of cardiovascular pharmacology 20010801

• Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium.

  British journal of pharmacology 20010801

• Effects of nebivolol and atenolol on insulin sensitivity and haemodynamics in hypertensive patients.

  Journal of hypertension 20010801

• Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double-blind, crossover study.

  Circulation 20010731

• Nebivolol, carvedilol and metoprolol do not influence cardiac Ca(2+) sensitivity.

  European journal of pharmacology 20010622

• [Heart and lung disease. Are beta blockers allowed in asthma?].

  MMW Fortschritte der Medizin 20010524

• Studies on the effect of alcohols on the chiral discrimination mechanisms of amylose stationary phase on the enantioseparation of nebivolol by HPLC.

  Journal of biochemical and biophysical methods 20010424

• Characterization of beta(1)-selectivity, adrenoceptor-G(s)-protein interaction and inverse agonism of nebivolol in human myocardium.

  British journal of pharmacology 20010401

• Beta-blockade with nebivolol enhances the acetylcholine-induced cutaneous vasodilation.

  Clinical pharmacology and therapeutics 20010401

• Nebivolol and airway responsiveness in the rabbit.

  Life sciences 20010323

• [Nebivolol, a beta blocker of the 3rd generation: modern therapy of arterial hypertension. Results of a multicenter observation study].

  Praxis 20010315

• HPLC enantiomeric resolution of nebivolol on normal and reversed amylose based chiral phases.

  Die Pharmazie 20010301

• Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells.

  Cardiovascular research 20010201

• [Effects of nebivolol, metoprolol and enalapril maleate on the state of endothelium-dependent arteriolar vasodilation in patients with essential hypertension].

  Likars'ka sprava 20010101

• [Nebivolol treatment in essential arterial hypertension].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20010101

• Beta-blockers of the third generation inhibit endothelin-1 liberation, mRNA production and proliferation of human coronary smooth muscle and endothelial cells.

  Journal of cardiovascular pharmacology 20001101

• Administration of nebivolol after coronary artery bypass in patients with altered left ventricular function.

  Journal of cardiovascular pharmacology 19930801

• Relationship between the sympatholytic action of nebivolol and hypotension.

  Journal of cardiovascular pharmacology 19920701

• The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various beta-adrenergic blockers.

  Molecular pharmacology 19881201