-
Targeting the A3 adenosine receptor for glaucoma treatment (review).
Molecular medicine reports 20130601
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Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
European journal of medicinal chemistry 20130501
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Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.
Journal of medicinal chemistry 20120628
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Treatment of plaque-type psoriasis with oral CF101: data from an exploratory randomized phase 2 clinical trial.
Journal of the European Academy of Dermatology and Venereology : JEADV 20120301
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Molecular mechanisms of A3 adenosine receptor-induced G1 cell cycle arrest and apoptosis in androgen-dependent and independent prostate cancer cell lines: involvement of intrinsic pathway.
Journal of cancer research and clinical oncology 20111001
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Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A₃ receptor agonist on hematopoiesis in sublethally γ-irradiated mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110901
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The role of adenosine receptors in rheumatoid arthritis.
Autoimmunity reviews 20101201
-
Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury.
The Journal of thoracic and cardiovascular surgery 20100801
-
Activation of adenosine A(3) receptors supports hematopoiesis-stimulating effects of granulocyte colony-stimulating factor in sublethally irradiated mice.
International journal of radiation biology 20100801
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Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor.
Biochemical pharmacology 20100715
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Induction of apoptosis by A3 adenosine receptor agonist N-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide in human leukaemia cells: a possible involvement of intracellular mechanism.
Acta physiologica (Oxford, England) 20100601
-
Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.
Bioorganic & medicinal chemistry 20100501
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Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 20100201
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2-Dialkynyl derivatives of (N)-methanocarba nucleosides: 'Clickable' A(3) adenosine receptor-selective agonists.
Bioorganic & medicinal chemistry 20100115
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Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
American journal of physiology. Gastrointestinal and liver physiology 20091201
-
Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists.
Bioorganic & medicinal chemistry 20091201
-
Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity.
Neoplasia (New York, N.Y.) 20091101
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Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.
Journal of cardiovascular pharmacology 20090501
-
Activation of adenosine A(3) receptors potentiates stimulatory effects of IL-3, SCF, and GM-CSF on mouse granulocyte-macrophage hematopoietic progenitor cells.
Physiological research 20090101
-
A3 adenosine receptor: pharmacology and role in disease.
Handbook of experimental pharmacology 20090101
-
Stimulation of ANP secretion by 2-Cl-IB-MECA through A(3) receptor and CaMKII.
Peptides 20081201
-
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Journal of medicinal chemistry 20081127
-
Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.
Journal of medicinal chemistry 20081023
-
Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.
European journal of pharmacology 20080820
-
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Journal of medicinal chemistry 20080724
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Homeostatic action of adenosine A3 and A1 receptor agonists on proliferation of hematopoietic precursor cells.
Experimental biology and medicine (Maywood, N.J.) 20080701
-
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.
Bioorganic & medicinal chemistry letters 20080501
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The anti-inflammatory effect of A3 adenosine receptor agonists: a novel targeted therapy for rheumatoid arthritis.
Expert opinion on investigational drugs 20071001
-
Adenosine A(3) receptor agonist acts as a homeostatic regulator of bone marrow hematopoiesis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20070701
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Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors.
The Journal of pharmacology and experimental therapeutics 20070701
-
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.
Journal of medicinal chemistry 20070111
-
Overexpression of A3 adenosine receptor in peripheral blood mononuclear cells in rheumatoid arthritis: involvement of nuclear factor-kappaB in mediating receptor level.
The Journal of rheumatology 20070101
-
Expression of adenosine receptors in cardiac fibroblasts as a function of insulin and glucose level.
Archives of biochemistry and biophysics 20061101
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Modulation of cardiac sarcoplasmic reticulum calcium release by aenosine: a protein kinase C- dependent pathway.
Molecular and cellular biochemistry 20060801
-
ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis.
Inflammatory bowel diseases 20060801
-
N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3 beta.
The Journal of pharmacology and experimental therapeutics 20060701
-
Effects of adenosine A(3) receptor agonist on bone marrow granulocytic system in 5-fluorouracil-treated mice.
European journal of pharmacology 20060524
-
The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor.
Bioorganic & medicinal chemistry letters 20060501
-
N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists.
Bioorganic & medicinal chemistry letters 20060501
-
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
-
Radioligand binding and functional responses of ligands for human recombinant adenosine A(3) receptors.
Autonomic & autacoid pharmacology 20060401
-
Adenosine receptors as therapeutic targets.
Nature reviews. Drug discovery 20060301
-
The PI3K-NF-kappaB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis.
Arthritis research & therapy 20060101
-
IB-MECA, an A3 adenosine receptor agonist prevents bone resorption in rats with adjuvant induced arthritis.
Clinical and experimental rheumatology 20060101
-
Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression.
Arthritis research & therapy 20060101
-
IB-MECA and cardioprotection.
Cardiovascular drug reviews 20060101
-
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Journal of medicinal chemistry 20051103
-
G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK.
Journal of immunology (Baltimore, Md. : 1950) 20050901
-
Induction of apoptosis by the adenosine derivative IB-MECA in parental or multidrug-resistant HL-60 leukemia cells: possible relationship to the effects on inhibitor of apoptosis protein levels.
Chemotherapy 20050801
-
(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.
Journal of medicinal chemistry 20050324
-
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
Journal of medicinal chemistry 20050310
-
Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes.
The Journal of pharmacology and experimental therapeutics 20050101
-
CF101, an agonist to the A3 adenosine receptor, enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model.
Neoplasia (New York, N.Y.) 20050101
-
Mesangial cell apoptosis induced by stimulation of the adenosine A3 receptor: signaling and apoptotic events.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20050101
-
Activation of A3 adenosine receptor provides lung protection against ischemia-reperfusion injury associated with reduction in apoptosis.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20041201
-
Activation of A3 adenosine receptors attenuates lung injury after in vivo reperfusion.
Anesthesiology 20041101
-
Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.
Journal of medicinal chemistry 20041021
-
Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor.
Bioorganic & medicinal chemistry letters 20041004
-
Negative chronotropic response to adenosine receptor stimulation in rat right atria after run training.
Clinical and experimental pharmacology & physiology 20041001
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2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists.
Journal of medicinal chemistry 20040909
-
Role of adenosine A1 receptor in the regulation of gastrin release.
The Journal of pharmacology and experimental therapeutics 20040801
-
An adenosine analog (IB-MECA) inhibits anchorage-dependent cell growth of various human breast cancer cell lines.
The international journal of biochemistry & cell biology 20040801
-
A2A adenosine receptor activation improves survival in mouse models of endotoxemia and sepsis.
The Journal of infectious diseases 20040515
-
An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B.
Oncogene 20040401
-
Effects of stable adenosine receptor agonists on bone marrow hematopoietic cells as inferred from the cytotoxic action of 5-fluorouracil.
Physiological research 20040101
-
A3 adenosine receptor activation in melanoma cells: association between receptor fate and tumor growth inhibition.
The Journal of biological chemistry 20031024
-
Inhibition of primary colon carcinoma growth and liver metastasis by the A3 adenosine receptor agonist CF101.
British journal of cancer 20031020
-
An adenosine analogue, IB-MECA, down-regulates estrogen receptor alpha and suppresses human breast cancer cell proliferation.
Cancer research 20031001
-
Protection from myocardial stunning by ischaemia and hypoxia with the adenosine A3 receptor agonist, IB-MECA.
European journal of pharmacology 20030923
-
N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor.
Journal of medicinal chemistry 20030828
-
A3 adenosine receptor agonist IB-MECA reduces myocardial ischemia-reperfusion injury in dogs.
American journal of physiology. Heart and circulatory physiology 20030801
-
Protein kinase C-delta mediates adenosine A3 receptor-induced delayed cardioprotection in mouse.
American journal of physiology. Heart and circulatory physiology 20030701
-
Activation of murine lung mast cells by the adenosine A3 receptor.
Journal of immunology (Baltimore, Md. : 1950) 20030701
-
Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells.
Blood 20030515
-
The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis.
European journal of pharmacology 20030418
-
The influence of adenosine A3 receptor agonist: IB-MECA, on scopolamine- and MK-801-induced memory impairment.
Behavioural brain research 20030417
-
A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure.
American journal of physiology. Renal physiology 20030201
-
Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells.
Molecular pharmacology 20030201
-
3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.
Journal of medicinal chemistry 20030130
-
Positive coupling of atypical adenosine A3 receptors on human eosinophils to adenylyl cyclase.
Biochemical and biophysical research communications 20030117
-
Targeting the A3 adenosine receptor for cancer therapy: inhibition of prostate carcinoma cell growth by A3AR agonist.
Anticancer research 20030101
-
Contractile responses to adenosine, R-PIA and ovalbumen in passively sensitized guinea-pig isolated airways.
British journal of pharmacology 20021101
-
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Journal of medicinal chemistry 20020926
-
Knockout of A3 adenosine receptors reduces mouse intraocular pressure.
Investigative ophthalmology & visual science 20020901
-
Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells.
Oncogene 20020606
-
Effects of adenosine receptor agonists on guinea-pig isolated working hearts and the role of endothelium and NO.
The Journal of pharmacy and pharmacology 20020601
-
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
The Journal of biological chemistry 20020419
-
Adenosine A(3) receptor-mediated potentiation of mucociliary transport and epithelial ciliary motility.
American journal of physiology. Lung cellular and molecular physiology 20020301
-
Late preconditioning elicited by activation of adenosine A(3) receptor in heart: role of NF- kappa B, iNOS and mitochondrial K(ATP) channel.
Journal of molecular and cellular cardiology 20020301
-
Regulation of glycogen metabolism in hepatocytes through adenosine receptors. Role of Ca2+ and cAMP.
European journal of pharmacology 20020222
-
A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.
Molecular pharmacology 20020201
-
Apparent activation of cardiovascular A1 adenosine receptors by A3 agonists.
American journal of physiology. Heart and circulatory physiology 20020201
-
Binding thermodynamics at the human A(3) adenosine receptor.
Biochemical pharmacology 20020115
-
Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2).
Biochemical pharmacology 20011101
-
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.
British journal of pharmacology 20011001
-
The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells.
British journal of pharmacology 20010901
-
Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells.
British journal of pharmacology 20010901
-
Role of adenosine in ischemic preconditioning in rats depends critically on the duration of the stimulus and involves both A(1) and A(3) receptors.
Cardiovascular research 20010901
-
Protection of IB-MECA against myocardial stunning in conscious rabbits is not mediated by the A1 adenosine receptor.
Basic research in cardiology 20010901
-
Right thing at a wrong time? Adenosine A3 receptors and cerebroprotection in stroke.
Annals of the New York Academy of Sciences 20010601
-
Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells.
European journal of pharmacology 20010518
-
A3 adenosine receptor stimulation modulates sarcoplasmic reticulum Ca(2+) release in rat heart.
Cardiovascular research 20010401
-
Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation.
Shock (Augusta, Ga.) 20010401
-
A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms.
Circulation research 20010316
-
A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis.
Molecular pharmacology 20010101
-
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.
Molecular pharmacology 20000501
-
Activation of the A3 adenosine receptor affects cell cycle progression and cell growth.
Naunyn-Schmiedeberg's archives of pharmacology 20000301
-
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.
Molecular pharmacology 19991001
-
Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 19980813
-
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
Journal of medicinal chemistry 19980507
-
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.
Naunyn-Schmiedeberg's archives of pharmacology 19980101
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Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor.
Molecular pharmacology 19971101
-
Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor.
The Journal of biological chemistry 19950609
-
The effects of adenosine A3 receptor stimulation on seizures in mice.
European journal of pharmacology 19950224
-
2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.
Journal of medicinal chemistry 19941014
-
Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.
Journal of medicinal chemistry 19940304