1532-84-9 | 1-Aminoisoquinoline

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$12.00	$9.00
1g	97%	in stock	$15.00	$11.00
5g	98%	in stock	$47.00	$33.00
10g	98%	in stock	$76.00	$53.00
25g	98%	in stock	$174.00	$122.00
100g	98%	in stock	$648.00	$454.00

Description

• Catalog Number: AB74957
• Chemical Name: 1-Aminoisoquinoline
• CAS Number: 1532-84-9
• Molecular Formula: C9H8N2
• Molecular Weight: 144.1732
• MDL Number: MFCD00024137
• SMILES: Nc1nccc2c1cccc2

Computed Properties

• Complexity: 136
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.9

Literature

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  Organic letters 20110902

• An efficient route to 1-aminoisoquinolines via AgOTf-catalyzed reaction of 2-alkynylbenzaldoxime with amine.

  Organic & biomolecular chemistry 20110707

• Biological evaluation of polyhalo 1,3-diazaheterocycle fused isoquinolin-1(2H)-imine derivatives.

  European journal of medicinal chemistry 20110401

• Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

  Bioorganic & medicinal chemistry letters 20110215

• Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.

  The Biochemical journal 20101001

• Direct metalation of heteroaromatic esters and nitriles using a mixed lithium-cadmium base. Subsequent conversion to dipyridopyrimidinones.

  The Journal of organic chemistry 20100205

• Sigma-1 ligands: Tic-hydantoin as a key pharmacophore.

  European journal of medicinal chemistry 20100101

• Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.

  Journal of medicinal chemistry 20091022

• Large-scale application of high-throughput molecular mechanics with Poisson-Boltzmann surface area for routine physics-based scoring of protein-ligand complexes.

  Journal of medicinal chemistry 20090528

• Aggregation of imine-based metallo-supramolecular architectures through pi-pi interactions.

  Dalton transactions (Cambridge, England : 2003) 20060614

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  Chemical research in toxicology 20050601

• Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20050301

• Identification and specificity studies of small-molecule ligands for SH3 protein domains.

  Journal of medicinal chemistry 20041021

• Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa.

  Bioorganic & medicinal chemistry letters 20041018

• Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants.

  Journal of medicinal chemistry 20031009

• Synthesis and pharmacological study of Rho-kinase inhibitors: pharmacomodulations on the lead compound Fasudil.

  Journal of enzyme inhibition and medicinal chemistry 20030401

• Substituted acrylamides as factor Xa inhibitors: improving bioavailability by P1 modification.

  Bioorganic & medicinal chemistry letters 20020805

• Chemistry of stable iminopropadienones, RN=C=C=C=O.

  The Journal of organic chemistry 20020419

• The design of competitive, small-molecule inhibitors of coagulation factor Xa.

  Current topics in medicinal chemistry 20010601