153773-82-1 | Ertapenem sodium

Packsize	Purity	Availability	Price	Discounted Price
1mg	97% HPLC	in stock	$7.00	$5.00
10mg	97% HPLC	in stock	$15.00	$11.00
50mg	97% HPLC	in stock	$33.00	$23.00
250mg	95%	in stock	$160.00	$112.00

Description

• Catalog Number: AW55131
• Chemical Name: Ertapenem sodium
• CAS Number: 153773-82-1
• Molecular Formula: C22H24N3NaO7S
• Molecular Weight: 497.4966
• MDL Number: MFCD09475566
• SMILES: O=C([C@H]1NC[C@H](C1)SC1=C(C(=O)O)N2[C@H]([C@H]1C)[C@H](C2=O)[C@H](O)C)Nc1cccc(c1)C(=O)[O-].[Na+]

Computed Properties

• Complexity: 900
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 6
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 7

Literature

• Emergence of NDM-1- and IMP-14a-producing Enterobacteriaceae in Thailand.

  The Journal of antimicrobial chemotherapy 20121101

• Inter-hospital outbreak of Klebsiella pneumoniae producing KPC-2 carbapenemase in Ireland.

  The Journal of antimicrobial chemotherapy 20121001

• [Ertapenem administered intravenously or subcutaneously for urinary tract infections caused by ESBL producing enterobacteriacea].

  Medecine et maladies infectieuses 20120901

• Spontaneous abscess of the anterior abdominal wall caused by Clostridium perfringens resistant to clindamycin.

  Surgical infections 20120801

• Ertapenem compared to combination drug therapy for the treatment of postpartum endometritis after cesarean delivery.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20120601

• Correlation between carbapenem consumption and resistance to carbapenems among Enterobacteriaceae isolates collected from patients with intra-abdominal infections at five medical centers in Taiwan, 2006-2010.

  International journal of antimicrobial agents 20120601

• Epidemiology and antimicrobial susceptibility profiles of Gram-negative bacteria causing urinary tract infections in the Asia-Pacific region: 2009-2010 results from the Study for Monitoring Antimicrobial Resistance Trends (SMART).

  International journal of antimicrobial agents 20120601

• Impact of revised CLSI breakpoints for susceptibility to third-generation cephalosporins and carbapenems among Enterobacteriaceae isolates in the Asia-Pacific region: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2002-2010.

  International journal of antimicrobial agents 20120601

• Comparison of ertapenem and ceftriaxone therapy for acute pyelonephritis and other complicated urinary tract infections in Korean adults: a randomized, double-blind, multicenter trial.

  Journal of Korean medical science 20120501

• Outcomes and characteristics of ertapenem-nonsusceptible Klebsiella pneumoniae bacteremia at a university hospital in Northern Taiwan: a matched case-control study.

  Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20120401

• Development of carbapenem resistance during therapy for non-typhoid Salmonella infection.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20120401

• Chronic pelvic osteomyelitis.

  Surgical infections 20120401

• Development of an UPLC-MS/MS method for the determination of antibiotic ertapenem on dried blood spots.

  Journal of pharmaceutical and biomedical analysis 20120305

• Susceptibility of European Escherichia coli clinical isolates from intra-abdominal infections, extended-spectrum β-lactamase occurrence, resistance distribution, and molecular characterization of ertapenem-resistant isolates (SMART 2008-2009).

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20120301

• Clinical outcomes with ertapenem as a first-line treatment option of infections caused by extended-spectrum β-lactamase producing gram-negative bacteria.

  The Annals of pharmacotherapy 20120301

• Rapid acquisition of decreased carbapenem susceptibility in a strain of Klebsiella pneumoniae arising during meropenem therapy.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20120201

• Effect of body mass index on treatment of complicated intra-abdominal infections in hospitalized adults: comparison of ertapenem with piperacillin-tazobactam.

  Surgical infections 20120201

• Low frequency of ertapenem-resistant intra-abdominal isolates of Escherichia coli from Latin America: susceptibility, ESBL-occurrence, and molecular characterisation (SMART 2008-2009).

  Journal of chemotherapy (Florence, Italy) 20120201

• Changes in antibiotic usage and susceptibility in nosocomial Enterobacteriaceae and Pseudomonas isolates following the introduction of ertapenem to hospital formulary.

  Epidemiology and infection 20120101

• Carbapenem stewardship: does ertapenem affect Pseudomonas susceptibility to other carbapenems? A review of the evidence.

  International journal of antimicrobial agents 20120101

• Ertapenem in the treatment of bacteremia caused by extended-spectrum beta-lactamase-producing Escherichia coli: a propensity score analysis.

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20120101

• Risk factors, molecular epidemiology and outcomes of ertapenem-resistant, carbapenem-susceptible Enterobacteriaceae: a case-case-control study.

  PloS one 20120101

• In vitro activity of tigecycline and molecular characterization of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates from a university hospital in south-western Germany.

  Chemotherapy 20120101

• Pharmacokinetics of free ertapenem in critically ill septic patients: intermittent versus continuous infusion.

  Minerva anestesiologica 20111101

• An epistemological dilemma: is ertapenem adequate to treat severe infections in critically ill patients?

  Minerva anestesiologica 20111101

• Trending eight years of in vitro activity of ertapenem and comparators against Escherichia coli from intra-abdominal infections in North America--SMART 2002-2009.

  Journal of chemotherapy (Florence, Italy) 20111001

• Citrobacter koseri as a cause of early periprosthetic infection after primary total hip arthroplasty.

  The Journal of arthroplasty 20110901

• Drug fever induced by ertapenem.

  QJM : monthly journal of the Association of Physicians 20110801

• Superior in vitro activity of ertapenem and piperacillin/tazobactam against recent clinical isolates of Proteus mirabilis from intra-abdominal infections (SMART 2009-2010).

  International journal of antimicrobial agents 20110801

• Ertapenem in plasma and peritoneal fluid from patients with severe intra-abdominal infections.

  The Journal of antimicrobial chemotherapy 20110801

• Does ertepenem alter the susceptibility of Pseudomonas aeruginosa to carbapenems?

  Journal of chemotherapy (Florence, Italy) 20110801

• [Clinical-economic analysis of antibacterial therapy of acute peritonitis].

  Klinichna khirurhiia 20110801

• Clinical epidemiology of carbapenem-intermediate or -resistant Enterobacteriaceae.

  The Journal of antimicrobial chemotherapy 20110701

• Molecular analysis of antimicrobial agent translocation through the membrane porin BpsOmp38 from an ultraresistant Burkholderia pseudomallei strain.

  Biochimica et biophysica acta 20110601

• Phenotypic and genotypic screening and clonal analysis of carbapenem-resistant Klebsiella pneumoniae at a single hospital.

  Microbial drug resistance (Larchmont, N.Y.) 20110601

• Activity of ertapenem and comparators against recent clinical isolates from intra-abdominal abscesses (SMART 2009).

  The Journal of infection 20110601

• Change in antipseudomonal carbapenem susceptibility in 25 hospitals across 9 years is not associated with the use of ertapenem.

  The Journal of antimicrobial chemotherapy 20110601

• Comparative in vitro susceptibility of Burkholderia pseudomallei to doripenem, ertapenem, tigecycline and moxifloxacin.

  International journal of antimicrobial agents 20110601

• Hand hygiene, and not ertapenem use, contributed to reduction of carbapenem-resistant Pseudomonas aeruginosa rates.

  Infection control and hospital epidemiology 20110601

• Phenotypic changes in a laboratory-derived ertapenem-resistant Escherichia coli strain.

  Journal of chemotherapy (Florence, Italy) 20110601

• Comparison of disk diffusion, Etest and VITEK2 for detection of carbapenemase-producing Klebsiella pneumoniae with the EUCAST and CLSI breakpoint systems.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20110501

• Ertapenem for the treatment of urinary tract infections caused by extended-spectrum β-lactamase-producing bacteria in children.

  Scandinavian journal of infectious diseases 20110501

• Carbapenem therapy for bacteremia due to extended-spectrum β-lactamase-producing Escherichia coli or Klebsiella pneumoniae.

  Diagnostic microbiology and infectious disease 20110501

• Risk factors and clinical significance of ertapenem-resistant Klebsiella pneumoniae in hospitalised patients.

  The Journal of hospital infection 20110501

• Osteomyelitis after bilateral sagittal split osteotomy: case report and a review of the management.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110401

• [Evolution of Escherichia coli resistance in community acquired peritonitis].

  Medecine et maladies infectieuses 20110401

• Comparison of in vitro activity of ertapenem with other carbapenems against extended-spectrum beta-lactamase-producing Escherichia coli and Kleibsella species isolated in a tertiary children's hospital.

  Expert opinion on pharmacotherapy 20110401

• Evaluation of a real-time PCR assay for the detection of the Klebsiella pneumoniae carbapenemase genes in microbiological samples in comparison with the modified Hodge test.

  American journal of clinical pathology 20110401

• In vitro susceptibilities of clinical isolates of ertapenem-non-susceptible Enterobacteriaceae to nemonoxacin, tigecycline, fosfomycin and other antimicrobial agents.

  International journal of antimicrobial agents 20110301

• Prophylaxis with ertapenem in patients with obstructive jaundice undergoing endoscopic retrograde cholangiopancreatography: safety, efficacy, and biliary penetration.

  Southern medical journal 20110301

• Risk factors for the acquisition of nosocomial infection with carbapenem-resistant Klebsiella pneumoniae.

  Southern medical journal 20110201

• New Delhi metallo-beta-lactamase from traveler returning to Canada.

  Emerging infectious diseases 20110201

• Central nervous system toxicity associated with ertapenem use.

  The Annals of pharmacotherapy 20110101

• [Investigation of the susceptibilities of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. strains to ertapenem and other carbapenems].

  Mikrobiyoloji bulteni 20110101

• Carbapenem stewardship: positive impact on hospital ecology.

  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101

• A prospective, multi centre, randomized clinical study to compare the efficacy and safety of Ertapenem 3 days versus Ampicillin-Sulbactam 3 days in the treatment of localized community acquired intra-abdominal infection. (T.E.A. Study: Three days Ertapenem vs three days Ampicillin-sulbactam).

  BMC gastroenterology 20110101

• Mandibular Actinomyces osteomyelitis complicating florid cemento-osseous dysplasia: case report.

  BMC oral health 20110101

• [Clinical and economic expedience of ertapenem therapy of complicated urinary tract infection].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101

• [Carbapenem resistance in Klebsiella pneumoniae clinical isolates from urinary tract infections].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20110101

• [Characteristics of ertapenem use in critical state patients].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101

• Pharmacokinetics of ertapenem in colorectal tissue.

  Chemotherapy 20110101

• Pharmacokinetics and tolerability of single-dose intravenous ertapenem in infants, children, and adolescents.

  The Pediatric infectious disease journal 20101201

• Ertapenem-resistant Enterobacteriaceae: risk factors for acquisition and outcomes.

  Infection control and hospital epidemiology 20101201

• Prevalence and characteristics of ertapenem-nonsusceptible Escherichia coli in a Taiwanese university hospital, 1999 to 2007.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20101101

• Improved performance of the modified Hodge test with MacConkey agar for screening carbapenemase-producing Gram-negative bacilli.

  Journal of microbiological methods 20101101

• Salvage therapy with tigecycline for recurrent infection caused by ertapenem-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae.

  Diagnostic microbiology and infectious disease 20101101

• [Treatment of community-acquired pneumonia in adults: ertapenem versus cefditoren?].

  Medicina clinica 20101016

• Refractory vertebral osteomyelitis due to CTX-M-14-producing Escherichia coli at ertapenem treatment in a patient with a coexisting urinary tract infection caused by the same pathogen.

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20100901

• Selective determination of ertapenem and imipenem in the presence of their degradants.

  Journal of chromatographic science 20100901

• Novel genetic context of multiple bla OXA-58 genes in Acinetobacter genospecies 3.

  The Journal of antimicrobial chemotherapy 20100801

• Decrease in serum valproic acid levels during treatment with ertapenem.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100801

• In vitro selection of ertapenem and piperacillin/tazobactam-resistant strains of Bacteroides fragilis and analysis of their virulence in gnotobiotic mice.

  Journal of chemotherapy (Florence, Italy) 20100801

• Epidemiologic trends, occurrence of extended-spectrum beta-lactamase production, and performance of ertapenem and comparators in patients with intra-abdominal infections: analysis of global trend data from 2002-2007 from the SMART study.

  Surgical infections 20100801

• Outpatient parenteral antimicrobial therapy: Recent developments and future prospects.

  Current opinion in investigational drugs (London, England : 2000) 20100801

• Ertapenem administered as outpatient parenteral antibiotic therapy for urinary tract infections caused by extended-spectrum-beta-lactamase-producing Gram-negative organisms.

  The Journal of antimicrobial chemotherapy 20100701

• Prospective randomized trial comparing short-term antibiotic therapy versus standard therapy for acute uncomplicated sigmoid diverticulitis.

  International journal of colorectal disease 20100601

• Transfer of carbapenem-resistant plasmid from Klebsiella pneumoniae ST258 to Escherichia coli in patient.

  Emerging infectious diseases 20100601

• Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.

  Biochemistry 20100504

• Changing prevalence of Escherichia coli with CTX-M-type extended-spectrum beta-lactamases in outpatient urinary E. coli between 2003 and 2008.

  Diagnostic microbiology and infectious disease 20100501

• Absence of association between use of ertapenem and change in antipseudomonal carbapenem susceptibility rates in 25 hospitals.

  Infection control and hospital epidemiology 20100501

• Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city.

  Diagnostic microbiology and infectious disease 20100401

• [Update on antimicrobial chemotherapy].

  Medecine et maladies infectieuses 20100301

• Ertapenem.

  Expert opinion on pharmacotherapy 20100301

• [Comparative activity of ertapenem against extended-spectrum beta-lactamase-producing or plasmid-mediated AmpC beta-lactamase-producing Klebsiella pneumoniae].

  Enfermedades infecciosas y microbiologia clinica 20100101

• Trends in the frequency of multiple drug-resistant Enterobacteriaceae and their susceptibility to ertapenem, imipenem, and other antimicrobial agents: data from the Study for Monitoring Antimicrobial Resistance Trends 2002 to 2007.

  Diagnostic microbiology and infectious disease 20100101

• Underdosing of ertapenem in critically ill patients with pneumonia confirmed by Monte Carlo simulations.

  International journal of antimicrobial agents 20100101

• The effect of tigecycline and ertapenem against clinical isolates of Brucella melitensis detected by E-test on different media.

  Indian journal of medical microbiology 20100101

• Clinical response to ertapenem in severe community-acquired pneumonia: a retrospective series in an elderly population.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20091101

• Emergence of blaKPC-containing Klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare system.

  The Journal of antimicrobial chemotherapy 20091101

• Addendum: why not ertapenem for surgical prophylaxis?

  The Medical letter on drugs and therapeutics 20090907

• Activity of Ertapenem and Ceftriaxone in the eradication of Salmonella in a model of experimental peritonitis in mice.

  Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20090901

• Ertapenem resistance and the Enterobacteriaceae.

  International journal of antimicrobial agents 20090801

• A case of beta lactam-induced visual hallucination.

  The New Zealand medical journal 20090703

• Selective determination of ertapenem in the presence of its degradation product.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090601

• Killing of Escherichia coli by beta-lactams at different inocula.

  Diagnostic microbiology and infectious disease 20090601

• Ertapenem susceptibility of extended spectrum beta-lactamase-producing Enterobacteriaceae at a tertiary care centre in India.

  Singapore medical journal 20090601

• Pharmacokinetics of once-daily dosing of ertapenem in critically ill patients with severe sepsis.

  International journal of antimicrobial agents 20090501

• The impact of ertapenem use on the susceptibility of Pseudomonas aeruginosa to imipenem: a hospital case study.

  Infection control and hospital epidemiology 20090501

• Detection of plasmid-mediated IMP-1 metallo-beta-lactamase and quinolone resistance determinants in an ertapenem-resistant Enterobacter cloacae isolate.

  Journal of Zhejiang University. Science. B 20090501

• Different sample stacking strategies for the determination of ertapenem and its impurities by micellar electrokinetic chromatography in pharmaceutical formulation.

  Journal of chromatography. A 20090403

• Ertapenem peritoneal fluid concentrations in adult surgical patients.

  International journal of antimicrobial agents 20090401

• Levofloxacin-induced delirium.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20090401

• Infection after elective colorectal surgery: bacteriological analysis of failures in a randomized trial of cefotetan vs. ertapenem prophylaxis.

  Surgical infections 20090401

• Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK.

  The Journal of antimicrobial chemotherapy 20090401

• New antimicrobial molecules and new antibiotic strategies.

  Seminars in respiratory and critical care medicine 20090401

• Increased postoperative cervical myelopathy and cord compression resulting from the use of Gelfoam.

  The spine journal : official journal of the North American Spine Society 20090201

• Safety and tolerability of ertapenem versus ceftriaxone in a double-blind study performed in children with complicated urinary tract infection, community-acquired pneumonia or skin and soft-tissue infection.

  International journal of antimicrobial agents 20090201

• [Multiple inflammatory liver pseudotumors and Enterococcus durans bacteremia].

  Gastroenterologia y hepatologia 20090201

• Pharmacokinetics of ertapenem in critically ill patients with acute renal failure undergoing extended daily dialysis.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090101

• Effect of early antibiotic prophylaxis with ertapenem and meropenem in experimental acute pancreatitis in rats.

  Journal of hepato-biliary-pancreatic surgery 20090101

• The use of ertapenem for the treatment of lower extremity infections.

  The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 20090101

• Recurrent bacteremia due to retained embolized glue following variceal obliteration.

  Endoscopy 20090101

• [In vitro activity of linezolid/ertapenem combination in resistant gram-positive bacteria].

  Mikrobiyoloji bulteni 20090101

• [Work of a multidisciplinary team in the control of the prescription of ertapenem].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101

• Accounting for the development of antibacterial resistance in the cost effectiveness of ertapenem versus piperacillin/tazobactam in the treatment of diabetic foot infections in the UK.

  PharmacoEconomics 20090101

• Ertapenem versus piperacillin/tazobactam for the treatment of complicated infections: a meta-analysis of randomized controlled trials.

  BMC infectious diseases 20090101

• The treatment of diabetic foot infections: focus on ertapenem.

  Vascular health and risk management 20090101

• Ertapenem.

  Kathmandu University medical journal (KUMJ) 20090101

• Cost-effectiveness evaluation of ertapenem versus piperacillin/tazobactam in the treatment of complicated intraabdominal infections accounting for antibiotic resistance.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101

• Ertapenem clearance during modeled continuous renal replacement therapy.

  The International journal of artificial organs 20081201

• Simultaneous determination of three carbapenem antibiotics in plasma by HPLC with ultraviolet detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081115

• Carbapenems and SHV-1 beta-lactamase form different acyl-enzyme populations in crystals and solution.

  Biochemistry 20081111

• Do CTX-M beta-lactamases hydrolyse ertapenem?

  The Journal of antimicrobial chemotherapy 20081101

• The challenge of multidrug resistance: the treatment of gram-negative rod infections.

  Shock (Augusta, Ga.) 20081001

• Ertapenem for treatment of extended-spectrum beta-lactamase-producing and multidrug-resistant gram-negative bacteraemia.

  Annals of the Academy of Medicine, Singapore 20081001

• Definitive risk factors for anastomotic leaks in elective open colorectal resection.

  Archives of surgery (Chicago, Ill. : 1960) 20080901

• Ertapenem: no effect on aerobic gram-negative susceptibilities to imipenem.

  The Journal of infection 20080801

• Health care-associated pneumonia: identification and initial management in the ED.

  The American journal of emergency medicine 20080701

• Ertapenem-induced acute pancreatitis in a surgical elderly patient.

  Pharmacy world & science : PWS 20080601

• [New antibiotics].

  La Revue de medecine interne 20080601

• Effects of hyperthermia on pharmacokinetics of ertapenem in rats.

  Fundamental & clinical pharmacology 20080601

• In vitro activity of ertapenem and other carbapenems against extended-spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae clinical isolates in a tertiary care center in Turkey.

  Expert opinion on pharmacotherapy 20080601

• Comparative costs of ertapenem and cefotetan as prophylaxis for elective colorectal surgery.

  Surgical infections 20080601

• Meta-analysis: ertapenem for complicated intra-abdominal infections.

  Alimentary pharmacology & therapeutics 20080501

• High-level cefepime resistance in Escherichia coli from Singapore producing OXA-1 beta-lactamase.

  International journal of antimicrobial agents 20080401

• Effect of body mass index and ertapenem versus cefotetan prophylaxis on surgical site infection in elective colorectal surgery.

  Surgical infections 20080401

• [Septic shock due to community-acquired complicated intra-abdominal infection treated with ertapenem: outcome in 25 cases].

  Revista espanola de anestesiologia y reanimacion 20080401

• Influence of ertapenem administration on the incidence of carbapenem-resistant Pseudomonas aeruginosa.

  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20080401

• A prospective, double-blind, multicenter, randomized trial comparing ertapenem 3 vs >or=5 days in community-acquired intraabdominal infection.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20080301

• Seizures associated with ertapenem.

  International journal of antimicrobial agents 20080301

• [In vitro activity of ertapenem against strains isolated from diabetic foot infections].

  Medecine et maladies infectieuses 20080301

• Pharmacodynamic activity of ertapenem versus multidrug-resistant genotypically characterized extended-spectrum beta-lactamase-producing Escherichia coli using an in vitro model.

  The Journal of antimicrobial chemotherapy 20080301

• The role of carbapenems in the treatment of severe nosocomial respiratory tract infections.

  Expert opinion on pharmacotherapy 20080301

• Activity of amikacin, ertapenem, ciprofloxacin and levofloxacin alone and in combination against resistant nosocomial pathogens by time-kill.

  The West Indian medical journal 20080301

• Rhodococcus equi lung infection in an allogeneic hematopoietic stem cell transplant recipient.

  Transplant infectious disease : an official journal of the Transplantation Society 20080201

• A simple and sensitive liquid chromatography-tandem mass spectrometry assay for the quantification of ertapenem in microdialysate.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201

• A simple and fast method for quantification of ertapenem using meropenem as internal standard in human plasma in a clinical setting.

  Therapeutic drug monitoring 20080201

• Efficacy of ertapenem for consolidation therapy of extended-spectrum beta-lactamase-producing gram-negative infections: a case series report.

  The Annals of pharmacotherapy 20080201

• A comparison of the stability of ertapenem and meropenem in pharmaceutical preparations in solid state.

  Journal of pharmaceutical and biomedical analysis 20080107

• Carbapenems: a potent class of antibiotics.

  Expert opinion on pharmacotherapy 20080101

• Parenteral carbapenems.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20080101

• Seizures associated with ertapenem use in patients with CNS disorders and renal insufficiency.

  Scandinavian journal of infectious diseases 20080101

• [Ertapenem in combined therapy for generalized peritonitis].

  Khirurgiia 20080101

• Ertapenem and all that.

  The National medical journal of India 20080101

• [In vitro activity of ertapenem against clinical bacterial isolates in 69 Spanish medical centers (E-test study)].

  Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20071201

• Comparative activity of ertapenem and piperacillin tazobactam in a murine systemic infection model with Bacteroides fragilis and Escherichia coli.

  Journal of medical microbiology 20071101

• Ertapenem for the treatment of extended-spectrum beta-lactamase-producing Gram-negative bacterial infections.

  International journal of antimicrobial agents 20071001

• Comment on: Best in class: a good principle for antibiotic usage to limit resistance development?

  The Journal of antimicrobial chemotherapy 20071001

• Diffusion of ertapenem into bone and synovial tissues.

  The Journal of antimicrobial chemotherapy 20071001

• Carbapenems in the USA: focus on doripenem.

  Expert review of anti-infective therapy 20071001

• Ertapenem or ticarcillin/clavulanate for the treatment of intra-abdominal infections or acute pelvic infections in pediatric patients.

  American journal of surgery 20070901

• [Ertapenem].

  Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20070901

• Activity of ertapenem and other antimicrobials against ESBL-producing enterobacteria isolated from urine in patients from Madrid.

  Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20070901

• Bowel colonization with vancomycin-resistant enterococci after antimicrobial therapy for intra-abdominal infections: observations from 2 randomized comparative clinical trials of ertapenem therapy.

  Diagnostic microbiology and infectious disease 20070801

• Efficacy of ertapenem in the treatment of early ventilator-associated pneumonia caused by extended-spectrum beta-lactamase-producing organisms in an intensive care unit.

  The Journal of antimicrobial chemotherapy 20070801

• Collateral damage of flomoxef therapy: in vivo development of porin deficiency and acquisition of blaDHA-1 leading to ertapenem resistance in a clinical isolate of Klebsiella pneumoniae producing CTX-M-3 and SHV-5 beta-lactamases.

  The Journal of antimicrobial chemotherapy 20070801

• Acute seizures in a patient receiving divalproex sodium after starting ertapenem therapy.

  Pharmacotherapy 20070801

• Antipneumococcal activity of ertapenem compared with gatifloxacin in a temperature-sensitive murine model of acute pneumonia.

  Journal of chemotherapy (Florence, Italy) 20070801

• In vitro activity of piperacillin/tazobactam and ertapenem against Bacteroides fragilis and Escherichia coli in pure and mixed cultures.

  Journal of medical microbiology 20070601

• Comparative costs of ertapenem and piperacillin-tazobactam in the treatment of diabetic foot infections.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070515

• Ertapenem resistance among Klebsiella and Enterobacter submitted in the UK to a reference laboratory.

  International journal of antimicrobial agents 20070401

• Is all free time above the minimum inhibitory concentration the same: implications for beta-lactam in vivo modelling.

  International journal of antimicrobial agents 20070301

• Clinical predictors of treatment failure for diabetic foot infections: data from a prospective trial.

  International wound journal 20070301

• Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration.

  The Journal of antimicrobial chemotherapy 20070201

• Polyethylene glycol versus sodium phosphate mechanical bowel preparation in elective colorectal surgery.

  American journal of surgery 20070201

• Ertapenem: the new carbapenem 5 years after first FDA licensing for clinical practice.

  Expert opinion on pharmacotherapy 20070201

• Randomized, multicenter, double-blind study of efficacy, safety, and tolerability of intravenous ertapenem versus piperacillin/tazobactam in treatment of complicated intra-abdominal infections in hospitalized adults.

  Surgical infections 20070201

• Ertapenem resistance of Escherichia coli.

  Emerging infectious diseases 20070201

• Stability of ertapenem in aqueous solutions.

  Journal of pharmaceutical and biomedical analysis 20070117

• Pharmacodynamic activity of ertapenem versus penicillin-susceptible and penicillin-non-susceptible Streptococcus pneumoniae using an in vitro model.

  The Journal of antimicrobial chemotherapy 20070101

• Susceptibilities of ESBL-producing Enterobacteriaceae to ertapenem, meropenem and piperacillin-tazobactam with and without clavulanic acid.

  Chemotherapy 20070101

• Comparative review of the carbapenems.

  Drugs 20070101

• Ertapenem susceptibility of extended spectrum beta-lactamase-producing organisms.

  Annals of clinical microbiology and antimicrobials 20070101

• Comparative antimicrobial susceptibility of aerobic and facultative bacteria from community-acquired bacteremia to ertapenem in Taiwan.

  BMC infectious diseases 20070101

• [In vitro activity of ertapenem against staphylococci].

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  The New England journal of medicine 20061221

• Carbapenems for surgical prophylaxis?

  The New England journal of medicine 20061221

• In vitro activities of ertapenem against drug-resistant Streptococcus pneumoniae and other respiratory pathogens from 12 Asian countries.

  Diagnostic microbiology and infectious disease 20061201

• Pharmacokinetics and lung concentrations of ertapenem in patients with ventilator-associated pneumonia.

  Intensive care medicine 20061201

• Comparative in vitro activity of ertapenem against extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated in Spain.

  International journal of antimicrobial agents 20061101

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  International journal of antimicrobial agents 20061101

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  Drugs of today (Barcelona, Spain : 1998) 20061101

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  International journal of antimicrobial agents 20061001

• Pharmacokinetics of ertapenem in patients with varying degrees of renal insufficiency and in patients on hemodialysis.

  Journal of clinical pharmacology 20061001

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  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20061001

• Development of a gradient elution preparative high performance liquid chromatography method for the recovery of the antibiotic ertapenem from crystallization process streams.

  Journal of chromatography. A 20060908

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  The Journal of infection 20060901

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  The Journal of antimicrobial chemotherapy 20060901

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  Shock (Augusta, Ga.) 20060801

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  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060715

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  International journal of antimicrobial agents 20060701

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  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060601

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  Medical mycology 20060501

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  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20060401

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  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307

• Challenges in the analytical method development and validation for an unstable active pharmaceutical ingredient.

  Journal of chromatographic science 20060301

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  Clinica chimica acta; international journal of clinical chemistry 20060201

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  International journal of antimicrobial agents 20060201

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  Scandinavian journal of infectious diseases 20060101

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  Lancet (London, England) 20051112

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  Journal of clinical pharmacology 20050601

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  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20041001

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  FEMS microbiology letters 20040501

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  Xenobiotica; the fate of foreign compounds in biological systems 20040401

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  The Journal of infection 20040101

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  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040101

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  Pathologie-biologie 20031001

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  Annals of surgery 20030201

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  Khirurgiia 20030101

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  Infectious diseases in obstetrics and gynecology 20030101

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  Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru 20030101

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  Khirurgiia 20030101

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  Clinical therapeutics 20021101

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  Diagnostic microbiology and infectious disease 20021001

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  International journal of antimicrobial agents 20020901

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  International journal of antimicrobial agents 20020801

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  Urology 20020701

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  Diagnostic microbiology and infectious disease 20020701

• Ertapenem once daily versus piperacillin-tazobactam 4 times per day for treatment of complicated skin and skin-structure infections in adults: results of a prospective, randomized, double-blind multicenter study.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020601

• Comparative in vitro activities of ertapenem against aerobic and facultative bacterial pathogens from patients with complicated skin and skin structure infections.

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  Journal of chemotherapy (Florence, Italy) 20020601

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  Diagnostic microbiology and infectious disease 20020501

• A study evaluating the efficacy, safety, and tolerability of ertapenem versus ceftriaxone for the treatment of community-acquired pneumonia in adults.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020415

• Ertapenem (Invanz)--a new parenteral carbapenem.

  The Medical letter on drugs and therapeutics 20020318

• Safety and local tolerability of intramuscularly administered ertapenem diluted in lidocaine: a prospective, randomized, double-blind study versus intramuscular ceftriaxone.

  Clinical therapeutics 20020301

• Ertapenem. A review of its microbiologic, pharmacokinetic and clinical aspects.

  Drugs of today (Barcelona, Spain : 1998) 20020301

• Ertapenem versus piperacillin-tazobactam for treatment of mixed anaerobic complicated intra-abdominal, complicated skin and skin structure, and acute pelvic infections.

  Surgical infections 20020101

• Surgical infections with enterococcus: outcome in patients treated with ertapenem versus piperacillin-tazobactam.

  Surgical infections 20020101

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  Expert opinion on investigational drugs 20010601