154-42-7 | 6-Thioguanine

Packsize	Purity	Availability	Price	Discounted Price
25mg	98%	in stock	$8.00	$5.00
100mg	98%	in stock	$10.00	$7.00
250mg	98%	in stock	$15.00	$10.00
1g	98%	in stock	$25.00	$17.00
5g	98%	in stock	$66.00	$46.00
10g	98%	in stock	$119.00	$84.00
25g	98%	in stock	$230.00	$161.00
100g	98%	in stock	$758.00	$531.00

Description

• Catalog Number: AD69925
• Chemical Name: 6-Thioguanine
• CAS Number: 154-42-7
• Molecular Formula: C5H5N5S
• Molecular Weight: 167.1917
• MDL Number: MFCD00127785
• SMILES: NC1NC(=S)C2=NC=NC2=N1

Computed Properties

• Complexity: 225
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 3
• XLogP3: -0.1

Literature

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• Gemtuzumab therapy for isolated extramedullary AML relapse following allogeneic stem-cell transplant.

  Nature clinical practice. Oncology 20070801

• Thioguanin-induced nodular regenerative hyperplasia of the liver-ROC analysis of different MR techniques.

  European radiology 20070701

• Thiopurine-induced liver injury in patients with inflammatory bowel disease: a systematic review.

  The American journal of gastroenterology 20070701

• 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.

  Clinical chemistry 20070701

• BRCA1 activates a G2-M cell cycle checkpoint following 6-thioguanine-induced DNA mismatch damage.

  Cancer research 20070701

• DHFR and MSH3 co-amplification in childhood acute lymphoblastic leukaemia, in vitro and in vivo.

  Carcinogenesis 20070601

• The quality of molecular response to chemotherapy is predictive for the outcome of AML1-ETO-positive AML and is independent of pretreatment risk factors.

  Leukemia 20070601

• Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.

  Biochemical pharmacology 20070601

• Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors.

  Therapeutics and clinical risk management 20070601

• An overview of the clinical use of ondansetron in preschool age children.

  Therapeutics and clinical risk management 20070601

• What can we learn from geographical comparisons of childhood cancer survival?

  British journal of cancer 20070521

• The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.

  Bioorganic & medicinal chemistry 20070515

• Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics.

  Cancer research 20070515

• Neutral carriers based polymeric membrane electrodes for selective determination of mercury (II).

  Analytica chimica acta 20070502

• Gemtuzumab ozogamicin-associated sinusoidal obstructive syndrome (SOS): an overview from the research on adverse drug events and reports (RADAR) project.

  Leukemia research 20070501

• Mechanisms of ischemic stroke in HIV-infected patients.

  Neurology 20070417

• Thiopurine metabolite monitoring in paediatric inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20070415

• DNA mismatch repair and Chk1-dependent centrosome amplification in response to DNA alkylation damage.

  Cell cycle (Georgetown, Tex.) 20070415

• Relationship between 6-mercaptopurine dose and 6-thioguanine nucleotide levels in patients with inflammatory bowel disease.

  Inflammatory bowel diseases 20070401

• Azathioprine and breastfeeding: is it safe?

  BJOG : an international journal of obstetrics and gynaecology 20070401

• Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis.

  The Journal of biological chemistry 20070323

• Anticancer nucleobase analogues 6-mercaptopurine and 6-thioguanine are novel substrates for equilibrative nucleoside transporter 2.

  International journal of pharmaceutics 20070321

• Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials.

  Pediatric blood & cancer 20070301

• Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol.

  Pediatric blood & cancer 20070301

• Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives.

  European journal of medicinal chemistry 20070301

• Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light.

  DNA repair 20070301

• Cytostatic drug treatment causes seeding of gene promoter methylation.

  European journal of cancer (Oxford, England : 1990) 20070301

• DNA mismatch repair initiates 6-thioguanine--induced autophagy through p53 activation in human tumor cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070215

• The effect of dietary folic acid deficiency on the cytotoxic and mutagenic responses to methyl methanesulfonate in wild-type and in 3-methyladenine DNA glycosylase-deficient Aag null mice.

  Mutation research 20070203

• Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070201

• Towards the mechanism of trimeric purine nucleoside phosphorylases: stopped-flow studies of binding of multisubstrate analogue inhibitor - 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine.

  Biophysical chemistry 20070201

• Toxicity of 6-thioguanine: no hepatotoxicity in a series of IBD patients treated with long-term, low dose 6-thioguanine. Some evidence for dose or metabolite level dependent effects?

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070201

• Extended thiopurine metabolite assessment during 6-thioguanine therapy for immunomodulation in Crohn's disease.

  Journal of clinical pharmacology 20070201

• Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070201

• Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine.

  Therapeutic drug monitoring 20070201

• Efficacy and safety of 6-thioguanine in the management of inflammatory bowel disease.

  Scandinavian journal of gastroenterology 20070201

• Autoimmune liver disease and rheumatic manifestations.

  Current opinion in rheumatology 20070101

• Therapeutic use of Aldara in chronic myeloid leukemia.

  Journal of translational medicine 20070101

• Traceless solid-phase synthesis and biological evaluation of purine analogs as inhibitors of multidrug resistance protein 4.

  Journal of combinatorial chemistry 20070101

• New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay.

  Environmental health perspectives 20070101

• Gastroparesis in patients with inactive Crohn's disease: a case series.

  BMC gastroenterology 20070101

• The expression of mismatched repair genes and their correlation with clinicopathological parameters and response to neo-adjuvant chemotherapy in breast cancer.

  International seminars in surgical oncology : ISSO 20070101

• A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells.

  Autophagy 20070101

• Genetic tests for predicting the toxicity and efficacy of anticancer chemotherapy.

  Neoplasma 20070101

• [Influence of antitumor preparations on the concentration of free radicals in cells of Fusarium bulbigenum var. blasticola fungus during primary and tumour-like secondary growth].

  Biofizika 20070101

• Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol.

  BMC biochemistry 20070101

• Daunorubicin-induced cell kill with 1-hour versus 24-hour infusions: a randomized comparison in children with newly diagnosed acute lymphoblastic leukemia.

  Klinische Padiatrie 20070101

• Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis.

  BMC molecular biology 20070101

• Fludarabine, treosulfan and etoposide sensitivity and the outcome of hematopoietic stem cell transplantation in childhood acute myeloid leukemia.

  Anticancer research 20070101

• Isolation and characterization of human cells resistant to retrovirus infection.

  Retrovirology 20070101

• [The results of a multicenter randomized trial on the treatment of acute myeloid leukemia of adults].

  Terapevticheskii arkhiv 20070101

• A systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel disease.

  Wiener klinische Wochenschrift 20070101

• Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome.

  Orphanet journal of rare diseases 20070101

• Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer.

  Journal of medicinal chemistry 20061228

• Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia.

  Blood 20061215

• Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases.

  Journal of medicinal chemistry 20061214

• Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines.

  British journal of cancer 20061204

• Inhibitory effect of 8-oxo-7,8-dihydro-2'-deoxyguanosine on the growth of KG-1 myelosarcoma in Balb/c nude mice.

  Leukemia research 20061101

• Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment.

  Cancer science 20061101

• Potential of the Akt inhibitor LY294005 to antagonize the efficacy of Cisplatin against HCT116 tumor cells in a DNA mismatch repair-dependent manner.

  International journal of oncology 20061101

• [Monitoring of thiopurine methyltransferase and thiopurine metabolites to optimize azathioprine therapy in inflammatory bowel disease].

  Gastroenterologia y hepatologia 20061101

• Non-adenine based purines accelerate wound healing.

  Purinergic signalling 20061101

• Thioguanine versus mercaptopurine in childhood ALL.

  Lancet (London, England) 20061014

• Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial.

  Lancet (London, England) 20061014

• A newly established GDL1 cell line from gpt delta mice well reflects the in vivo mutation spectra induced by mitomycin C.

  Mutation research 20061010

• Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.

  Journal of hepatology 20061001

• Novel therapies for Crohn's disease: focus on immunomodulators and antibiotics.

  The Annals of pharmacotherapy 20061001

• Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs.

  British journal of clinical pharmacology 20061001

• Etoposide pharmacokinetics in children treated for acute myeloid leukemia.

  Anti-cancer drugs 20061001

• The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia.

  Clinical pharmacology and therapeutics 20061001

• HGPRT mutation induction by N-ethyl-N-nitrosourea as measured by 6-thioguanine resistance is higher in male than in female Syrian hamster fetuses.

  Birth defects research. Part B, Developmental and reproductive toxicology 20061001

• Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside.

  Biochemical pharmacology 20060928

• Oral outpatient chemotherapy medication errors in children with acute lymphoblastic leukemia.

  Cancer 20060915

• Review article: thiopurines in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20060901

• Structure-activity relationship studies on the immune stimulatory effects of base-modified CpG toll-like receptor 9 agonists.

  ChemMedChem 20060901

• Next steps on the thiopurine methyltransferase 6-thioguanine nucleotide pathway.

  Journal of pediatric gastroenterology and nutrition 20060901

• Whole-blood thiopurine S-methyltransferase activity with genotype concordance: a new, simplified phenotyping assay.

  Annals of clinical biochemistry 20060901

• Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia.

  International journal of nanomedicine 20060901

• Further examination of the effects of nitrosylation on Alternaria alternata mycotoxin mutagenicity in vitro.

  Mutation research 20060714

• Conventional systemic agents for psoriasis. A systematic review.

  The Journal of rheumatology 20060701

• Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations.

  PLoS genetics 20060701

• Protective effects of melatonin against low- and high-LET irradiation.

  Journal of radiation research 20060601

• The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine.

  Organic & biomolecular chemistry 20060507

• Autoimmune liver disease.

  Current opinion in gastroenterology 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Nodular regenerative hyperplasia: a reversible entity associated with azathioprine therapy.

  European journal of gastroenterology & hepatology 20060501

• 6-Thioguanine-related chronic hepatotoxicity and variceal haemorrhage in children treated for acute lymphoblastic leukaemia--a dual-centre experience.

  Journal of pediatric gastroenterology and nutrition 20060501

• Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines.

  Biochemical and biophysical research communications 20060428

• 6-Thioguanine-related hepatotoxicity in patients with inflammatory bowel disease: dose or level dependent?

  Journal of hepatology 20060401

• Thiopurines in inflammatory bowel disease: new strategies for optimization of pharmacotherapy?

  Current gastroenterology reports 20060401

• 5-aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine.

  Inflammatory bowel diseases 20060401

• Frequency and types of spontaneous Hprt lymphocyte mutations in Pms2-deficient mice.

  Mutation research 20060320

• Truncation of the C-terminus of human MLH1 blocks intracellular stabilization of PMS2 and disrupts DNA mismatch repair.

  DNA repair 20060307

• Treatment for myeloid leukaemia of Down syndrome: population-based experience in the UK and results from the Medical Research Council AML 10 and AML 12 trials.

  British journal of haematology 20060301

• Randomized use of cyclosporin A (CsA) to modulate P-glycoprotein in children with AML in remission: Pediatric Oncology Group Study 9421.

  Blood 20060215

• Chronic liver disease related to 6-thioguanine in children with acute lymphoblastic leukaemia.

  Journal of hepatology 20060201

• Erybraedin C and bitucarpin A, two structurally related pterocarpans purified from Bituminaria bituminosa, induced apoptosis in human colon adenocarcinoma cell lines MMR- and p53-proficient and -deficient in a dose-, time-, and structure-dependent fashion.

  Chemico-biological interactions 20060201

• Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation.

  Pediatric blood & cancer 20060201

• Acute myelogenous leukemia in elderly patients not eligible for intensive chemotherapy: the dark side of the moon.

  Annals of oncology : official journal of the European Society for Medical Oncology 20060201

• Pharmacokinetics of 6-thioguanine in patients with inflammatory bowel disease.

  Therapeutic drug monitoring 20060201

• NMR imino proton exchange experiments on duplex DNA primarily monitor the opening of purine bases.

  Journal of the American Chemical Society 20060125

• Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells.

  British journal of cancer 20060116

• The effect of steroid on myeloid leukemic cells: the potential of short-course high-dose methylprednisolone treatment in inducing differentiation, apoptosis and in stimulating myelopoiesis.

  Leukemia research 20060101

• MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells.

  Environmental and molecular mutagenesis 20060101

• 6-Thioguanine treatment in inflammatory bowel disease: a critical appraisal by a European 6-TG working party.

  Digestion 20060101

• Early prediction of therapy response in patients with acute myeloid leukemia by nucleosomal DNA fragments.

  BMC cancer 20060101

• Treatments for astrocytic tumors in children: current and emerging strategies.

  Paediatric drugs 20060101

• Efficacy and tolerability of gemtuzumab ozogamicin (anti-CD33 monoclonal antibody, CMA-676, Mylotarg) in children with relapsed/refractory myeloid leukemia.

  BMC cancer 20060101

• Identification of differentially expressed mRNA transcripts in drug-resistant versus parental human melanoma cell lines.

  Anticancer research 20060101

• [Xenobiotic-metabolizing polymorphic enzymes. An opportunity for individualized drug treatment].

  Bulletin de l'Academie nationale de medecine 20060101

• [Acute lymphoblastic leukemia in children with initial leucocytosis above 50,000/mm3: summary of treatment results of Polish Pediatric Leukemia/Lymphoma Study Group].

  Przeglad lekarski 20060101

• Evaluation of efalizumab using safe psoriasis control.

  BMC dermatology 20060101

• Colostrinin decreases spontaneous and induced mutation frequencies at the hprt locus in Chinese hamster V79 cells.

  Journal of experimental therapeutics & oncology 20060101

• Impaired transport as a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia cells.

  Nucleosides, nucleotides & nucleic acids 20060101

• Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients.

  Pharmacological reports : PR 20060101

• Thiopurines, DNA damage, DNA repair and therapy-related cancer.

  British medical bulletin 20060101

• [Auditory evoked potentials in patients after acute children's lymphoblastic leukemia treatment].

  Przeglad lekarski 20060101

• Clinical pharmacogenomics of thiopurine S-methyltransferase.

  Current clinical pharmacology 20060101

• Immunosuppression, skin cancer, and ultraviolet A radiation.

  The New England journal of medicine 20051222

• The leukocyte count predicts the efficacy of treatment with azathioprine in inflammatory bowel disease.

  European journal of medical research 20051207

• Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000.

  Leukemia 20051201

• The thiopurines: an update.

  Investigational new drugs 20051201

• Observations on the use of allopurinol in combination with azathioprine or mercaptopurine.

  Alimentary pharmacology & therapeutics 20051201

• In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib: identification of T-cell ALL and FAB M5 AML as the most sensitive subsets.

  Blood 20051115

• Role of 5'-nucleotidase in thiopurine metabolism: enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment.

  Clinica chimica acta; international journal of clinical chemistry 20051101

• Toxicity due to 6-thioquanine.

  Pediatric blood & cancer 20051101

• Effects of azathioprine and its metabolites on repair mechanisms of the intestinal epithelium in vitro.

  Regulatory peptides 20051101

• Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy.

  Clinical chemistry 20051101

• Uranyl acetate induces hprt mutations and uranium-DNA adducts in Chinese hamster ovary EM9 cells.

  Mutagenesis 20051101

• Treatment of older patients with AML.

  Critical reviews in oncology/hematology 20051101

• Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Münster Group 87.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051101

• 6-Thioguanine for Crohn's disease during pregnancy: thiopurine metabolite measurements in both mother and child.

  Scandinavian journal of gastroenterology 20051101

• [Neutrophilic eccrine hidradenitis secondary to thioguanine in a neutropenic patient].

  Actas dermo-sifiliograficas 20051101

• Thiopurine therapies: problems, complexities, and progress with monitoring thioguanine nucleotides.

  Therapeutic drug monitoring 20051001

• The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients.

  Alimentary pharmacology & therapeutics 20051001

• A prospective, open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis.

  Scandinavian journal of gastroenterology 20051001

• Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action.

  Journal of biotechnology 20050929

• On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprine or 6-mercaptopurine intolerant IBD patients.

  World journal of gastroenterology 20050921

• Azathioprine and UVA light generate mutagenic oxidative DNA damage.

  Science (New York, N.Y.) 20050916

• High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy.

  Blood 20050915

• 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone [MX] shows initiating and promoting activities in a two-stage BALB/c 3T3 cell transformation assay.

  Mutagenesis 20050901

• Are MTT assays the right tool to analyze drug resistance caused by ABC-transporters in patient samples?

  Leukemia & lymphoma 20050901

• Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine.

  Alimentary pharmacology & therapeutics 20050901

• On the limitation of 6-tioguaninenucleotide monitoring during tioguanine treatment.

  Alimentary pharmacology & therapeutics 20050901

• Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

  The FEBS journal 20050901

• Inhibition of MHC class I is a virulence factor in herpes simplex virus infection of mice.

  PLoS pathogens 20050901

• Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors.

  Cancer research 20050815

• A multicenter assessment of liver toxicity by MRI and biopsy in IBD patients on 6-thioguanine.

  Journal of hepatology 20050801

• Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes.

  Nature genetics 20050801

• The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.

  Therapeutic drug monitoring 20050801

• Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.

  Journal of gastroenterology and hepatology 20050801

• Interference free and simplyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050705

• Medical treatment of inflammatory bowel diseases.

  Current opinion in gastroenterology 20050701

• Differential cytotoxicity of anticancer agents in pre- and post-immortal lymphoblastoid cell lines.

  Biological & pharmaceutical bulletin 20050701

• Modeling of purine derivatives transport across cell membranes based on their partition coefficient determination and quantum chemical calculations.

  Journal of medicinal chemistry 20050630

• Suppression of hREV1 expression reduces the rate at which human ovarian carcinoma cells acquire resistance to cisplatin.

  Molecular pharmacology 20050601

• Immunophenotypic cell lineage and in vitro cellular drug resistance in childhood relapsed acute lymphoblastic leukaemia.

  European journal of cancer (Oxford, England : 1990) 20050601

• Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis.

  Electrophoresis 20050601

• In vivo mutagenesis induced by benzo[a]pyrene instilled into the lung of gpt delta transgenic mice.

  Environmental and molecular mutagenesis 20050501

• Interaction between cadmium and aromatic DNA adducts in hprt mutagenesis during foetal development.

  Mutagenesis 20050501

• The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.

  Molecular cancer therapeutics 20050501

• hMutS alpha is protected from ubiquitin-proteasome-dependent degradation by atypical protein kinase C zeta phosphorylation.

  Journal of molecular biology 20050422

• Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives.

  Bioorganic & medicinal chemistry 20050401

• Promising treatment of autoimmune hepatitis with 6-thioguanine after adverse events on azathioprine.

  European journal of gastroenterology & hepatology 20050401

• Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20050401

• Diesel exhaust particulate matter dispersed in a phospholipid surfactant induces chromosomal aberrations and micronuclei but not 6-thioguanine-resistant gene mutation in V79 cells.

  Journal of toxicology and environmental health. Part A 20050326

• Casein kinase 2 regulates both apoptosis and the cell cycle following DNA damage induced by 6-thioguanine.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050315

• Portal hypertension develops in a subset of children with standard risk acute lymphoblastic leukemia treated with oral 6-thioguanine during maintenance therapy.

  Pediatric blood & cancer 20050301

• Bystander effects may modulate ultraviolet A and B radiation-induced delayed mutagenesis.

  Radiation research 20050301

• Prediction of individual response to chemotherapy in patients with acute myeloid leukaemia using the chemosensitivity index Ci.

  British journal of haematology 20050301

• Measurement of thiopurine methyl transferase activity guides dose-initiation and prevents toxicity from azathioprine.

  The New Zealand medical journal 20050225

• Formation and dissolution processes of the 6-thioguanine (6TG) self-assembled monolayer. A kinetic study.

  The journal of physical chemistry. B 20050203

• Selective inhibition of inflammatory gene expression in activated T lymphocytes: a mechanism of immune suppression by thiopurines.

  The Journal of pharmacology and experimental therapeutics 20050201

• New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutant.

  DNA repair 20050102

• Chronic myelocytic leukemia--Part II: Approaches to and molecular monitoring of therapy.

  Clinical laboratory science : journal of the American Society for Medical Technology 20050101

• Determination of caspase-3 activation fails to predict chemosensitivity in primary acute myeloid leukemia blasts.

  BMC cancer 20050101

• Qualitatively and quantitatively similar effects of active and passive maternal tobacco smoke exposure on in utero mutagenesis at the HPRT locus.

  BMC pediatrics 20050101

• Bystander effects in UV-induced genomic instability: antioxidants inhibit delayed mutagenesis induced by ultraviolet A and B radiation.

  Journal of carcinogenesis 20050101

• Psoriasis vulgaris flare during efalizumab therapy does not preclude future use: a case series.

  BMC dermatology 20050101

• Effect of chemotherapy on the mutation frequency of ovarian cancer cells at the HPRT locus.

  Anticancer research 20050101

• How important is onset of action in ulcerative colitis therapy?

  Drugs 20050101

• Impact of efalizumab on patient-reported outcomes in high-need psoriasis patients: results of the international, randomized, placebo-controlled Phase III Clinical Experience Acquired with Raptiva (CLEAR) trial [NCT00256139].

  BMC dermatology 20050101

• Genetic interactions between BLM and DNA ligase IV in human cells.

  The Journal of biological chemistry 20041231

• Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis.

  British journal of cancer 20041213

• Isolation of fast purine nucleotide synthase ribozymes.

  Journal of the American Chemical Society 20041208

• Assessment of thiopurine methyltransferase and metabolite formation during thiopurine therapy: results from a large Swedish patient population.

  Therapeutic drug monitoring 20041201

• Utility of azathioprine metabolite measurements in post-transplant recurrent autoimmune and immune-mediated hepatitis.

  Pediatric transplantation 20041201

• Theoretical study of the guanine --> 6-thioguanine substitution in duplexes, triplexes, and tetraplexes.

  Journal of the American Chemical Society 20041110

• Possible trimethoprim/sulfamethoxazole-induced aseptic meningitis.

  The Annals of pharmacotherapy 20041101

• Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant.

  British journal of cancer 20041101

• Reviewing the mechanism of action of thiopurine drugs: towards a new paradigm in clinical practice.

  Medical science monitor : international medical journal of experimental and clinical research 20041101

• Whose TPMT activity is it anyway?

  Annals of clinical biochemistry 20041101

• Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis.

  European journal of gastroenterology & hepatology 20041101

• LET and ion-species dependence for mutation induction and mutation spectrum on hprt locus in normal human fibroblasts.

  Uchu Seibutsu Kagaku 20041101

• Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia.

  Blood 20041015

• Establishment and characterisation of a human carcinoma cell line with acquired resistance to Aplidin.

  British journal of cancer 20041004

• Toxicity and efficacy of intensive chemotherapy for children with acute lymphoblastic leukemia (ALL) after first bone marrow or extramedullary relapse.

  Pediatric blood & cancer 20041001

• The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment.

  Nucleosides, nucleotides & nucleic acids 20041001

• Mutation in the ITPA gene predicts intolerance to azathioprine.

  Nucleosides, nucleotides & nucleic acids 20041001

• A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line.

  Biochemical and biophysical research communications 20040903

• Diagnosis of 6 mercaptopurine hepatotoxicity post liver transplantation utilizing metabolite assays.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040901

• Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease.

  The American journal of surgical pathology 20040901

• Improved HPLC methodology for monitoring thiopurine metabolites in patients on thiopurine therapy.

  Clinical biochemistry 20040901

• The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease.

  The American journal of gastroenterology 20040901

• Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20040901

• CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.

  Molecular cancer therapeutics 20040901

• [Immunosuppressive therapy for inflammatory bowel disease: consensus by the Austrian working group on IBD].

  Zeitschrift fur Gastroenterologie 20040901

• Acute sinusoidal obstruction syndrome after 6-thioguanine therapy for Crohn's disease.

  Inflammatory bowel diseases 20040901

• Capecitabine in combination with mitomycin C in patients with gastrointestinal cancer: results of an extended multicentre phase-I trial.

  British journal of cancer 20040831

• Electrochemical characterization of a mixed self-assembled monolayer of 6-thioguanine and guanine on a mercury electrode.

  Journal of colloid and interface science 20040801

• Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease.

  Gut 20040801

• Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs.

  Journal of neurochemistry 20040801

• A novel method for screening viral interferon-resistance genes.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20040801

• Sequence- and base-specific delivery of nitric oxide to cytidine and 5-methylcytidine leading to efficient deamination.

  Journal of the American Chemical Society 20040728

• An investigation of the genotoxic effects of N-nitrosomorpholine in mammalian cells.

  Chemico-biological interactions 20040720

• Medical approaches and future options in chronic active ulcerative colitis.

  International journal of colorectal disease 20040701

• Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?

  Annals of clinical biochemistry 20040701

• Reference intervals for thiopurine S-methyltransferase activity in red blood cells using 6-thioguanine as substrate and rapid non-extraction liquid chromatography.

  Annals of clinical biochemistry 20040701

• Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease.

  Inflammatory bowel diseases 20040701

• Using pharmacogenetics to improve drug safety and efficacy.

  JAMA 20040616

• Thioguanine-nucleotides do not predict efficacy of tioguanine in Crohn's disease.

  Alimentary pharmacology & therapeutics 20040615

• Structural and functional analysis of mutations at the human hypoxanthine phosphoribosyl transferase (HPRT1) locus.

  Human mutation 20040601

• Frequency distribution of thiopurine S-methyltransferase activity in red blood cells of a healthy Japanese population.

  Therapeutic drug monitoring 20040601

• Thioguanine-induced symptomatic thrombocytopenia.

  The American journal of gastroenterology 20040601

• Purine nucleoside antimetabolites in development for the treatment of cancer.

  Current opinion in investigational drugs (London, England : 2000) 20040601

• Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway.

  Biochemical and biophysical research communications 20040521

• Priming with granulocyte colony-stimulating factor--relation to high-dose cytarabine in acute myeloid leukemia.

  The New England journal of medicine 20040520

• Pegylated liposomal doxorubicin in combination with mitomycin C, infusional 5-fluorouracil and sodium folinic acid. A phase-I-study in patients with upper gastrointestinal cancer.

  British journal of cancer 20040517

• Frequent HPRT mutations in paroxysmal nocturnal haemoglobinuria reflect T cell clonal expansion, not genomic instability.

  British journal of haematology 20040501

• Chronic hepatotoxicity following 6-thioguanine therapy for childhood acute lymphoblastic leukaemia.

  British journal of haematology 20040501

• An improved HPLC method for the quantitation of 6-mercaptopurine and its metabolites in red blood cells.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040501

• Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20040501

• Prognostic impact of early response to induction therapy as assessed by multiparameter flow cytometry in acute myeloid leukemia.

  Haematologica 20040501

• Differentiating agents + low-dose chemotherapy in the management of old/poor prognosis patients with acute myeloid leukemia or myelodysplastic syndrome.

  Haematologica 20040501

• Pharmacogenetic determinants of outcome in acute lymphoblastic leukaemia.

  British journal of haematology 20040501

• A subgroup of microsatellite stable colorectal cancers has elevated mutation rates and different responses to alkylating and oxidising agents.

  British journal of cancer 20040419

• Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity.

  Clinical pharmacology and therapeutics 20040401

• Analytic aspects of monitoring therapy with thiopurine medications.

  Therapeutic drug monitoring 20040401

• Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen.

  Drug metabolism and disposition: the biological fate of chemicals 20040301

• Combination therapy to treat moderate to severe psoriasis.

  Journal of the American Academy of Dermatology 20040301

• 6-thioguanine-buried alive?

  Gastroenterology 20040301

• Enzyme-catalyzed activation of anticancer prodrugs.

  Pharmacological reviews 20040301

• Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

  Pharmacogenetics 20040301

• Effect of antimetabolite immunosuppressants on Flaviviridae, including hepatitis C virus.

  Transplantation 20040227

• SNPs in cancer research and treatment.

  British journal of cancer 20040223

• A novel CRM1-mediated nuclear export signal governs nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase following genotoxic stress.

  The Journal of biological chemistry 20040213

• Importance of clustered 2'-O-(2-aminoethyl) residues for the gene targeting activity of triple helix-forming oligonucleotides.

  Biochemistry 20040210

• Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione.

  The international journal of biochemistry & cell biology 20040201

• 6-Thioguanine can cause serious liver injury in inflammatory bowel disease patients.

  Journal of pediatric gastroenterology and nutrition 20040201

• Granulocyte-macrophage colony-stimulating factor to increase efficacy of mitoxantrone, etoposide and cytarabine in previously untreated elderly patients with acute myeloid leukaemia: a Swedish multicentre randomized trial.

  British journal of haematology 20040201

• Cancer pharmacogenetics.

  British journal of cancer 20040112

• Infectious complications in pediatric acute myeloid leukemia: analysis of the prospective multi-institutional clinical trial AML-BFM 93.

  Leukemia 20040101

• Children with acute myeloblastic leukemia presenting with extramedullary infiltration: the effects of high-dose steroid treatment.

  Leukemia research 20040101

• Early nodular hyperplasia of the liver occurring with inflammatory bowel diseases in association with thioguanine therapy.

  Archives of pathology & laboratory medicine 20040101

• Pilot study of idarubicin-based intensive-timing induction therapy for children with previously untreated acute myeloid leukemia: Children's Cancer Group Study 2941.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040101

• Pulmonary tuberculosis in a child receiving intensive chemotherapy for acute myeloblastic leukemia.

  Journal of pediatric hematology/oncology 20040101

• Oral treatment of acute myeloid leukaemia with etoposide, thioguanine, and idarubicin (ETI) in elderly patients: a prospective randomised comparison with intravenous cytarabine, idarubicin, and thioguanine in the second and third treatment cycle.

  European journal of haematology 20040101

• Clinical utility of thiopurine S-methyltransferase genotyping.

  American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 20040101

• Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-gamma production in patients with Crohn's disease on AZA therapy.

  Digestive diseases and sciences 20040101

• The results of treatment with idarubicin in childhood acute nonlymphoblastic leukemia.

  The Turkish journal of pediatrics 20040101

• Mutation carrier testing in Lesch-Nyhan syndrome families: HPRT mutant frequency and mutation analysis with peripheral blood T lymphocytes.

  Genetic testing 20040101

• Creation of non-human primate neurogenetic disease models by gene targeting and nuclear transfer.

  Reproductive biology and endocrinology : RB&E 20040101

• Mismatch repair and DNA damage signalling.

  DNA repair 20040101

• Role of DNA mismatch repair in apoptotic responses to therapeutic agents.

  Environmental and molecular mutagenesis 20040101

• Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells.

  BMC pharmacology 20040101

• [Immunologic monitoring in children with acute lymphoblastic leukemia during maintenance treatment with regard to co-existing infections].

  Wiadomosci lekarskie (Warsaw, Poland : 1960) 20040101

• [Diagnostic significance of reticulocyte analysis by flow cytometry, in children with acute lymphoblastic leukaemia (ALL) on chemotherapy].

  Medycyna wieku rozwojowego 20040101

• [Second neoplasm in a 13-year-old boy complicated by Crohn's disease. Case report].

  Medycyna wieku rozwojowego 20040101

• Therapeutic drug monitoring in patients with inflammatory bowel disease and established azathioprine therapy.

  Clinical drug investigation 20040101

• Toxicological assessment of noxious inhalants.

  GMS current topics in otorhinolaryngology, head and neck surgery 20040101

• A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia.

  Blood 20031215

• 6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TAD-HAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myeloid leukemia (AML): a randomized trial of the German AML Cooperative Group.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031215

• Combination chemotherapy in advanced gastrointestinal cancers: ex vivo sensitivity to gemcitabine and mitomycin C.

  British journal of cancer 20031215

• Determination of thiopurine S-methyltransferase activity in erythrocytes using 6-thioguanine as substrate and a non-extraction liquid chromatographic technique.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031205

• Optimizing immunomodulator therapy for inflammatory bowel disease.

  Current gastroenterology reports 20031201

• Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice.

  Phytotherapy research : PTR 20031201

• Synthesis of base substituted 2-hydroxy-3-(purin-9-yl)-propanoic acids and 4-(purin-9-yl)-3-butenoic acids.

  Nucleosides, nucleotides & nucleic acids 20031201

• Acute myeloid leukemia presenting as non-neutropenic colitis in an infant.

  Journal of pediatric gastroenterology and nutrition 20031101

• Low L-selectin (CD62L) expression in acute myeloid leukemia correlates with a bad cytogenetic risk.

  European journal of haematology 20031101

• 6TG: when less is more than you bargained for.

  Inflammatory bowel diseases 20031101

• A novel Escherichia coli strain allows functional analysis of guanylate kinase drug resistance and sensitivity.

  Analytical biochemistry 20031101

• High-performance liquid chromatographic assay of metabolites of thioguanine and mercaptopurine in capillary blood.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031025

• Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme.

  Journal of molecular biology 20031024

• Drug methylation in cancer therapy: lessons from the TPMT polymorphism.

  Oncogene 20031020

• Thioguanine offers no advantage over mercaptopurine in maintenance treatment of childhood ALL: results of the randomized trial COALL-92.

  Blood 20031015

• Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics.

  Toxicological sciences : an official journal of the Society of Toxicology 20031001

• Veno-occlusive disease in patients receiving thiopurines during maintenance therapy for childhood acute lymphoblastic leukaemia.

  British journal of haematology 20031001

• Enhancement and inhibition by 2'-O-hydroxyethyl residues of gene targeting mediated by triple helix forming oligonucleotides.

  Nucleosides, nucleotides & nucleic acids 20031001

• LET and ion-species dependence for cell killing and mutation induction in normal human fibroblasts.

  Uchu Seibutsu Kagaku 20031001

• Secondary myeloid leukemia and myelodysplastic syndromes in patients treated for Hodgkin's disease: a report from the German Hodgkin's Lymphoma Study Group.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030915

• Increased age at diagnosis has a significantly negative effect on outcome in children with Down syndrome and acute myeloid leukemia: a report from the Children's Cancer Group Study 2891.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030915

• Role of mismatch repair in the induction of chromosomal aberrations and sister chromatid exchanges in cells treated with different chemotherapeutic agents.

  Cancer chemotherapy and pharmacology 20030901

• Commentary on: Differences in nucleotide hydrolysis contribute to the differences between erythrocyte 6-thioguanine nucleotide concentrations determined by two widely used methods.

  Clinical chemistry 20030901

• No benefit from adding GM-CSF to induction chemotherapy in transforming myelodysplastic syndromes: better outcome in patients with less proliferative disease.

  Leukemia 20030901

• Pharmacological monitoring of azathioprine therapy.

  Scandinavian journal of gastroenterology 20030901

• A randomized trial of induction therapy (daunorubicin, vincristine, prednisone versus daunorubicin, vincristine, prednisone, cytarabine and 6-thioguanine) in adult acute lymphoblastic leukemia with long-term follow-up: an Eastern Cooperative Oncology Group Study (E3486).

  Leukemia & lymphoma 20030901

• Extramedullary acute myeloid leukemia (granulocytic sarcoma) with arm paresis, maculopapular exanthema and organ involvement.

  Leukemia & lymphoma 20030901

• Chromosomal rearrangement in Down syndrome with acute myeloid leukemia.

  Indian journal of pediatrics 20030901

• Isolated IgA deficiency after chemotherapy for acute myelogenous leukemia in an infant.

  Pediatric hematology and oncology 20030901

• Tioguanine in patients with Crohn's disease intolerant or resistant to azathioprine/mercaptopurine.

  Alimentary pharmacology & therapeutics 20030815

• Treatment concepts for elderly patients with acute myeloid leukemia.

  Wiener klinische Wochenschrift 20030814

• Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy.

  Toxicological sciences : an official journal of the Society of Toxicology 20030801

• Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- mice.

  Molecular pharmacology 20030801

• A novel t(15;17) translocation in acute myeloid leukaemia not associated with PML/RARalpha rearrangement.

  Clinical and laboratory haematology 20030801

• Acute arterial thrombosis in acute promyelocytic leukaemia.

  Clinical and laboratory haematology 20030801

• 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients.

  Gastroenterology 20030801

• 6-thioguanine nucleotides and thiopurine methyltransferase activity: important factors determining response to treatment and incidence of adverse effects from azathioprine and 6-MP.

  The New Zealand medical journal 20030725

• 6-thioguanine nucleotides and thiopurine methyltransferase activity: important factors determining response to treatment and incidence of adverse effects from azathioprine and 6-MP.

  The New Zealand medical journal 20030725

• High variation of tioguanine absorption in patients with chronic active Crohn's disease.

  Alimentary pharmacology & therapeutics 20030715

• Dose reduction of coadministered 6-mercaptopurine decreases myelotoxicity following high-dose methotrexate in childhood leukemia.

  Leukemia 20030701

• Tolerance of nitrosurea-based multiagent chemotherapy regime for low-grade pediatric gliomas.

  Journal of neuro-oncology 20030701

• Assessment of the frequency of mutant (hprt-) T lymphocytes from peripheral blood of patients with Hashimoto's thyroiditis.

  Thyroid : official journal of the American Thyroid Association 20030701

• Remission maintenance by tioguanine in chronic active Crohn's disease.

  Alimentary pharmacology & therapeutics 20030615

• Distinct tissue distribution of metabolites of the novel glutathione-activated thiopurine prodrugs cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)guanine and 6-thioguanine in the mouse.

  Drug metabolism and disposition: the biological fate of chemicals 20030601

• DNA mismatch repair (MMR) mediates 6-thioguanine genotoxicity by introducing single-strand breaks to signal a G2-M arrest in MMR-proficient RKO cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030601

• Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia.

  Clinical pharmacology and therapeutics 20030601

• The role of multidrug resistance protein 1 (MRP1) in transport of fluorescent anions across the human erythrocyte membrane.

  The Journal of membrane biology 20030515

• Immunophenotypic evidence of leukemia after induction therapy predicts relapse: results from a prospective Children's Cancer Group study of 252 patients with acute myeloid leukemia.

  Blood 20030501

• Azathioprine: current status and future considerations.

  International journal of dermatology 20030501

• 6-TG for IBD. simple, but safe?

  The American journal of gastroenterology 20030501

• Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine.

  The American journal of gastroenterology 20030501

• The DNA methylation inhibitor 5-azacytidine modulates 6-thioguanine toxicity in mammalian cells.

  Toxicology letters 20030430

• Human melanoma TrkC: its association with a purine-analog-sensitive kinase activity.

  Journal of cellular biochemistry 20030401

• Consensus and controversy in the management of pediatric Crohn disease: an international survey.

  Journal of pediatric gastroenterology and nutrition 20030401

• Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030401

• Autologous peripheral blood stem cell transplantation in first remission adult acute myeloid leukaemia--an intention to treat analysis and comparison of outcome using a predictive model based on the MRC AML10 cohort.

  Hematology (Amsterdam, Netherlands) 20030401

• Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia.

  British journal of cancer 20030310

• High survival rate in childhood non-Hodgkin lymphoma without CNS involvement: results of BFM 95 study in Kuwait.

  Pediatric hematology and oncology 20030301

• Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.

  Journal of clinical gastroenterology 20030301

• Recent advances in immunomodulation in the treatment of inflammatory bowel disease.

  European journal of gastroenterology & hepatology 20030301

• [Therapy of chronic inflammatory bowel diseases with azathioprine, 6-mercaptopurine and 6-thioguanine. Clinico-pharmacologic aspects].

  Deutsche medizinische Wochenschrift (1946) 20030221

• 6-thioguanine--efficacy and safety in chronic active Crohn's disease.

  Alimentary pharmacology & therapeutics 20030215

• Differences in nucleotide hydrolysis contribute to the differences between erythrocyte 6-thioguanine nucleotide concentrations determined by two widely used methods.

  Clinical chemistry 20030201

• Molecular characterization of mitomycin C-induced large deletions and tandem-base substitutions in the bone marrow of gpt delta transgenic mice.

  Chemical research in toxicology 20030201

• Optimizing treatment with thioguanine derivatives in inflammatory bowel disease.

  Best practice & research. Clinical gastroenterology 20030201

• Structure and dynamics of thioguanine-modified duplex DNA.

  The Journal of biological chemistry 20030110

• Mercaptopurine metabolite results in clinical gastroenterology practice.

  Alimentary pharmacology & therapeutics 20030101

• A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues.

  Cancer research 20030101

• 6-thioguanine: a new old drug to procure remission in inflammatory bowel disease.

  Internal medicine journal 20030101

• Combination therapy in childhood leukaemia: in vitro studies of thiopurines and inhibitors of purine metabolism on apoptosis.

  Annals of clinical biochemistry 20030101

• 6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment.

  European journal of gastroenterology & hepatology 20030101

• Mutations induced by (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells.

  Environmental and molecular mutagenesis 20030101

• [Significance of TPMT activity and TGNs level detection for individualizing 6-mercaptopurine chemotherapy].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030101

• Utility of measuring 6-methylmercaptopurine and 6-thioguanine nucleotide levels in managing inflammatory bowel disease patients treated with 6-mercaptopurine in a clinical practice setting.

  Journal of clinical gastroenterology 20030101

• Novel transgenic rat for in vivo genotoxicity assays using 6-thioguanine and Spi- selection.

  Environmental and molecular mutagenesis 20030101

• [Analysis of causes of death during intensive chemotherapy according to treatment protocol AML-BFM 93].

  Klinische Padiatrie 20030101

• Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis.

  BMC microbiology 20030101

• [The influence of age, gender and modifications of therapeutic protocols on physical development of children and adolescents after completion of therapy for acute lymphoblastic leukemia].

  Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych 20030101

• Genomic instability in drug-resistant human melanoma cell lines detected by Alu-I-arbitrary-primed PCR.

  Anticancer research 20030101

• Allelic variants of the thiopurine methyltransferase (TPMT) gene in the Colombian population.

  Methods and findings in experimental and clinical pharmacology 20030101

• Chemotherapy for progressive low-grade gliomas in children older than ten years: the Dana-Farber experience.

  Pediatric hematology and oncology 20030101

• [Survival evaluation of children with acute lymphoblastic leukemia treated with Berlin-Frankfurt-Munich trial].

  Jornal de pediatria 20030101

• Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites.

  Current pharmaceutical design 20030101

• Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis.

  Nucleosides, nucleotides & nucleic acids 20030101

• Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency.

  Pediatric dermatology 20030101

• Safety of thiopurines in the treatment of inflammatory bowel disease.

  Scandinavian journal of gastroenterology. Supplement 20030101

• Mutations induced by 1,3-butadiene metabolites, butadiene diolepoxide, and 1,2,3,4-diepoxybutane at the Hprt locus in CHO-K1 cells.

  Molecules and cells 20021231

• Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.

  Molecular pharmacology 20021201

• Advances in medical therapy for Crohn's disease.

  Current gastroenterology reports 20021201

• Treatment of psoriasis with 6-thioguanine and hepatic venoocclusive disease.

  Journal of the American Academy of Dermatology 20021201

• Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo.

  The Journal of clinical investigation 20021115

• Identification of transdominant-negative genetic suppressor elements derived from hMSH2 that mediate resistance to 6-thioguanine.

  Molecular pharmacology 20021101

• Stable expression of rat sulfotransferase 1B1 in V79 cells: activation of benzylic alcohols to mutagens.

  Carcinogenesis 20021101

• Impact of granulocyte colony-stimulating factor use during induction for acute myelogenous leukemia in children: a report from the Children's Cancer Group.

  Journal of pediatric hematology/oncology 20021101

• Blast crisis of chronic myeloid leukemia: diagnosis prompted by T(8;9).

  Journal of pediatric hematology/oncology 20021101

• The glutathione-activated thiopurine prodrugs trans-6-(2-acetylvinylthio)guanine and cis-6-(2-acetylvinylthio)purine cause less in vivo toxicity than 6-thioguanine after single- and multiple-dose regimens.

  Molecular cancer therapeutics 20021101

• Thiopurine S-methyltransferase activity in Japanese subjects: metabolic activity of 6-mercaptopurine 6-methylation in different TPMT genotypes.

  Clinica chimica acta; international journal of clinical chemistry 20020901

• Eradication of human immunodeficiency virus type 1-infected cells by a combination of antimetabolic cytotoxic chemotherapy and antiviral chemotherapy in vitro: a pilot study.

  The Journal of infectious diseases 20020901

• Azathioprine metabolite measurements in the treatment of autoimmune hepatitis in pediatric patients: a preliminary report.

  Journal of pediatric gastroenterology and nutrition 20020901

• Minisatellite and Hprt mutations in V79 cells irradiated with helium ions and gamma rays.

  International journal of radiation biology 20020901

• Ex vivo drug resistance profile in childhood acute myelogenous leukemia: no drug is more effective in comparison to acute lymphoblastic leukemia.

  Leukemia & lymphoma 20020901

• SAB--a promising new treatment to improve remission rates in AML in the elderly?

  British journal of haematology 20020801

• Anti-angiogenic activity of the purine analog 6-thioguanine.

  Leukemia 20020801

• Multifaceted resistance of gliomas to temozolomide.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020801

• Improved outcome in high-risk childhood acute lymphoblastic leukemia defined by prednisone-poor response treated with double Berlin-Frankfurt-Muenster protocol II.

  Blood 20020715

• The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs.

  Molecular pharmacology 20020701

• Leucocyte versus erythrocyte thioguanine nucleotide concentrations in children taking thiopurines for acute lymphoblastic leukaemia.

  Cancer chemotherapy and pharmacology 20020701

• Symptomatic hypoglycemia in children receiving oral purine analogues for treatment of childhood acute lymphoblastic leukemia.

  Medical and pediatric oncology 20020701

• Advances in the medical therapy of inflammatory bowel disease.

  Current opinion in gastroenterology 20020701

• A mouse kidney cell line with a G:C --> C:G transversion mutator phenotype.

  Mutation research 20020619

• Surface layers of 6-thioguanine on the mercury electrode.

  Journal of colloid and interface science 20020615

• Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.

  Therapeutic drug monitoring 20020601

• Anaplastic large cell lymphoma in childhood: analysis of 72 patients treated on The United Kingdom Children's Cancer Study Group chemotherapy regimens.

  British journal of haematology 20020601

• Tetrasomy 13 as the sole cytogenetic abnormality in acute myeloid leukemia M1 without maturation.

  Cancer genetics and cytogenetics 20020601

• Infrared spectra of 6-thioguanine tautomers. An experimental and theoretical approach.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020601

• Long-term follow-up of patients >or=60 yr old with acute myeloid leukaemia treated with intensive chemotherapy.

  European journal of haematology 20020601

• [Study on the silica-induced cytotoxicity and hprt gene mutagenisis in rat lung fibroblasts and alveolar type II epithelial cells].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20020601

• Mutagenicity of 7H-dibenzo[c,g]carbazole and its tissue specific derivatives in genetically engineered Chinese hamster V79 cell lines stably expressing cytochrome P450.

  Mutation research 20020527

• Implication of protein kinase C in the regulation of DNA mismatch repair protein expression and function.

  The Journal of biological chemistry 20020517

• [New techniques for optimization of thiopurine therapy in leukemia and transplantation].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20020430

• Ambiguous coding is required for the lethal interaction between methylated DNA bases and DNA mismatch repair.

  DNA repair 20020429

• Photodynamic therapy of DNA mismatch repair-deficient and -proficient tumour cells.

  British journal of cancer 20020408

• Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice.

  The Journal of pharmacology and experimental therapeutics 20020401

• X-ray induced mutation in Syrian hamster fetal cells.

  Mutation research 20020320

• Childhood hyperuricemia and acute renal failure resulting from a missense mutation in the HPRT gene.

  American journal of medical genetics 20020315

• Pharmacological characterization of the ATP-dependent low K(m) guanosine 3',5'-cyclic monophosphate (cGMP) transporter in human erythrocytes.

  Biochemical pharmacology 20020301

• Hypomethylation and multiple sclerosis, the susceptibility factor?

  Neurologia (Barcelona, Spain) 20020301

• Acute myeloid leukemia: treatment over 60.

  Reviews in clinical and experimental hematology 20020301

• Aphidicolin induces 6-thioguanine resistant mutants in human diploid fibroblasts.

  Mutation research 20020220

• Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues.

  The Biochemical journal 20020201

• Effect of methotrexate polyglutamates on thioguanine nucleotide concentrations during continuation therapy of acute lymphoblastic leukemia with mercaptopurine.

  Leukemia 20020201

• Diversity of the apoptotic response to chemotherapy in childhood leukemia.

  Leukemia 20020201

• Specific [(3)H]-guanosine binding sites in rat brain membranes.

  British journal of pharmacology 20020201

• Flow cytometric determination of HPRT-variants in human peripheral blood lymphocytes.

  Mutation research 20020129

• HPLC determination of thiopurine nucleosides and nucleotides in vivo in lymphoblasts following mercaptopurine therapy.

  Clinical chemistry 20020101

• Frequent detection of T cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria.

  Blood 20020101

• Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome.

  Blood 20020101

• Inflammatory bowel disease.

  Endoscopy 20020101

• Genetic toxicology studies with glutaraldehyde.

  Journal of applied toxicology : JAT 20020101

• The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.

  Pharmacogenomics 20020101

• 6-thioguanine in the treatment of psoriasis: a case report and literature review.

  Journal of cutaneous medicine and surgery 20020101

• Physical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays.

  Genome biology 20020101

• The PICM-19 cell line as an in vitro model of liver bile ductules: effects of cAMP inducers, biopeptides and pH.

  Cells, tissues, organs 20020101

• Cytotoxic and mutagenic action of 193-nm and 213-nm laser radiation.

  Journal of refractive surgery (Thorofare, N.J. : 1995) 20020101

• Comparative pharmacokinetics of oral 6-mercaptopurine and intravenous 6-mercaptopurine riboside in children.

  Pediatrics international : official journal of the Japan Pediatric Society 20011201

• Mechanisms of tolerance to DNA damaging therapeutic drugs.

  Carcinogenesis 20011201

• Why measure thiopurine methyltransferase activity? Direct administration of 6-thioguanine might be the alternative for 6-mercaptopurine or azathioprine.

  Gut 20011201

• Toxoplasma gondii: mechanism of the parasitostatic action of 6-thioxanthine.

  Experimental parasitology 20011201

• Renal cell carcinoma as a secondary malignancy after treatment of acute promyelocytic leukemia.

  Journal of pediatric hematology/oncology 20011201

• Continuing therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of methotrexate, 6-mercaptopurine and 6-thioguanine.

  Cancer treatment reviews 20011201

• Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation.

  Cancer research 20011115

• Substitution F569S converts UapA, a specific uric acid-xanthine transporter, into a broad specificity transporter for purine-related solutes.

  Journal of molecular biology 20011102

• Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide.

  Gut 20011101

• Treatment of psoriasis. Part 2. Systemic therapies.

  Journal of the American Academy of Dermatology 20011101

• Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.

  Leukemia 20011101

• Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine.

  Alimentary pharmacology & therapeutics 20011101

• The mouse guanylate kinase double mutant E72Q/D103N is a functional adenylate kinase.

  Protein engineering 20011101

• Desmutagenic and bio-antimutagenic activity of docosahexaenoic acid and eicosapentaenoic acid in cultured Chinese hamster V79 cells.

  Mutation research 20011018

• Hypoxia-induced enrichment and mutagenesis of cells that have lost DNA mismatch repair.

  Cancer research 20011015

• Intensive timed sequential remission induction chemotherapy with high-dose cytarabine for childhood acute myeloid leukemia.

  Medical and pediatric oncology 20011001

• Suppression of spontaneous and hydrogen peroxide-induced mutagenesis by the antioxidant ascorbate in mismatch repair-deficient human colon cancer cells.

  Carcinogenesis 20011001

• Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method.

  Therapeutic drug monitoring 20011001

• Targeting DNA mismatch repair for radiosensitization.

  Seminars in radiation oncology 20011001

• 6-mercaptopurine metabolite levels in children with inflammatory bowel disease.

  Journal of pediatric gastroenterology and nutrition 20011001

• Co-amplification of dhfr and a homologue of hmsh3 in a Chinese hamster methotrexate-resistant cell line correlates with resistance to a range of chemotherapeutic drugs.

  Cancer chemotherapy and pharmacology 20011001

• Acute arterial occlusion as the presenting feature in acute promyelocytic leukaemia.

  British journal of haematology 20011001

• Managing the glucocorticoid dependent inflammatory bowel disease patient.

  Seminars in gastrointestinal disease 20011001

• FAB M4 and high CD14 surface expression is associated with high cellular resistance to Ara-C and daunorubicin: implications for clinical outcome in acute myeloid leukaemia.

  European journal of haematology 20011001

• Enhanced expression and activity of DNA polymerase beta in human ovarian tumor cells: impact on sensitivity towards antitumor agents.

  Oncogene 20010927

• Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine.

  The Journal of biological chemistry 20010907

• Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML11 trial.

  Blood 20010901

• The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial.

  Blood 20010901

• Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010901

• The histone deacetylase inhibitor trichostatin A reduces nickel-induced gene silencing in yeast and mammalian cells.

  Mutation research 20010808

• hMSH3 overexpression and cellular response to cytotoxic anticancer agents.

  Carcinogenesis 20010801

• Erythroleukaemia in the north of England: a population based study.

  Journal of clinical pathology 20010801

• Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.

  Cancer research 20010801

• An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy.

  Inflammatory bowel diseases 20010801

• 6-Thioguanine: a naked bullet? (Or how pharmacogenomics can make old drugs brand new).

  Inflammatory bowel diseases 20010801

• Reversal of cytosine arabinoside (ara-C) resistance by the synergistic combination of 6-thioguanine plus ara-C plus PEG-asparaginase (TGAP) in human leukemia lines lacking or expressing p53 protein.

  Cancer chemotherapy and pharmacology 20010801

• Remission induction therapy: the more intensive the better?

  Cancer chemotherapy and pharmacology 20010801

• Photoactivation of DNA thiobases as a potential novel therapeutic option.

  Current biology : CB 20010724

• Hamster and rat fetal cells have low spontaneous mutation frequencies and rates.

  Mutation research 20010701

• Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood.

  Journal of chromatography. B, Biomedical sciences and applications 20010605

• 6-Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations.

  British journal of clinical pharmacology 20010601

• Amplification of ERBB2, RARA, and TOP2A genes in a myelodysplastic syndrome transforming to acute myeloid leukemia.

  Cancer genetics and cytogenetics 20010601

• [Primary pulmonary manifestation of extramedullary acute myelocytic leukemia].

  Pneumologie (Stuttgart, Germany) 20010601

• Molecular characterisation of camptothecin-induced mutations at the hprt locus in Chinese hamster cells.

  Mutation research 20010509

• In vivo mutant frequency of thioguanine-resistant T-cells in the peripheral blood and lymph nodes of melanoma patients.

  Mutation research 20010509

• Cell killing and mutation induction by heavy ion beams.

  International journal of molecular medicine 20010501

• Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease.

  Gut 20010501

• Human thiopurine S-methyltransferase activity in uremia and after renal transplantation.

  European journal of clinical pharmacology 20010501

• Mouse 4T1 breast tumor model.

  Current protocols in immunology 20010501

• Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocol.

  British journal of haematology 20010401

• Isodicentric 7p, idic(7)(q11.2), in acute myeloid leukemia associated with older age and favorable response to induction chemotherapy: a new clinical entity?

  Genes, chromosomes & cancer 20010301

• Analysis of mutational effects at the HPRT locus in human G(0) phase lymphocytes irradiated in vitro with gamma rays.

  Mutation research 20010301

• Immunosuppressive and cytotoxic drugs in the treatment of rheumatic skin disorders.

  Seminars in cutaneous medicine and surgery 20010301

• Plasma pharmacokinetics and cerebrospinal fluid penetration of thioguanine in children with acute lymphoblastic leukemia: a collaborative Pediatric Oncology Branch, NCI, and Children's Cancer Group study.

  Cancer chemotherapy and pharmacology 20010301

• Heterozygosity for the thiopurine methyltransferase *3A allele in an acute non-lymphoblastic leukaemia patient with delayed marrow regeneration following H-DAT chemotherapy.

  British journal of haematology 20010301

• Pretreatment leukaemia cell drug resistance is correlated to clinical outcome in acute myeloid leukaemia.

  European journal of haematology 20010301

• Acute myeloid leukaemia (AML): treatment of the older patient.

  Best practice & research. Clinical haematology 20010301

• P53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin.

  Cancer research 20010215

• A novel protein complex distinct from mismatch repair binds thioguanylated DNA.

  Molecular pharmacology 20010201

• Bilateral breast relapse in acute myelogenous leukemia.

  Journal of pediatric hematology/oncology 20010201

• New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine.

  Clinical biochemistry 20010201

• Pharmacotherapeutic options in inflammatory bowel disease: an update.

  Pharmacy world & science : PWS 20010201

• The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase.

  Journal of biochemical and biophysical methods 20010130

• Antimutagenic activity of fluphenazine in short-term tests.

  Mutagenesis 20010101

• Thioguanine for refractory psoriasis: a 4-year experience.

  Journal of the American Academy of Dermatology 20010101

• Antimetabolites and cytotoxic drugs.

  Dermatologic clinics 20010101

• Molecular dynamics of DNA quadruplex molecules containing inosine, 6-thioguanine and 6-thiopurine.

  Biophysical journal 20010101

• Patients with de novo acute myeloid leukaemia and complex karyotype aberrations show a poor prognosis despite intensive treatment: a study of 90 patients.

  British journal of haematology 20010101

• Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine.

  Cancer research 20010101

• Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease.

  Scandinavian journal of gastroenterology 20010101

• 6-mercaptopurine dosage and pharmacokinetics influence the degree of bone marrow toxicity following high-dose methotrexate in children with acute lymphoblastic leukemia.

  Leukemia 20010101

• Gene- and tissue-specificity of mutation in Big Blue rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene.

  Environmental and molecular mutagenesis 20010101

• [Thioguanine, pancreatotoxicity?].

  Therapie 20010101

• High 6-thioguanine nucleotide levels and low thiopurine methyltransferase activity in patients with lupus erythematosus treated with azathioprine.

  American journal of therapeutics 20010101

• Role of glutathione S-transferase mu (GSTM1) in styrene-7,8-oxide toxicity and mutagenicity.

  Environmental and molecular mutagenesis 20010101

• Pharmacokinetic considerations in the treatment of inflammatory bowel disease.

  Clinical pharmacokinetics 20010101

• Pharmacogenetics: the therapeutic drug monitoring of the future?

  Clinical pharmacokinetics 20010101

• Favorable outcome for children and adolescents with T-cell lymphoblastic lymphoma with an intensive ALL-type therapy without local radiotherapy.

  Annals of hematology 20010101

• Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation.

  BMC biotechnology 20010101

• Recent advances in the pharmacogenomics of thiopurine methyltransferase.

  The pharmacogenomics journal 20010101

• A purine-sensitive mechanism regulates the molecular program for axon growth.

  Restorative neurology and neuroscience 20010101

• Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20000501

• Veno-occlusive disease of the liver associated with thiopurines in a child with acute lymphoblastic leukemia.

  Pediatric hematology and oncology 20000101

• Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

  Biochemical pharmacology 19951109

• Marked differences in the role of O6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrosourea, or N-ethyl-N-nitrosourea.

  Cancer research 19950501

• Mutagenicity in vitro of 3,4-dichloro-5-hydroxy-2(5H)-furanone (mucochloric acid), a chlorine disinfection by-product in drinking water.

  Environmental and molecular mutagenesis 19950101

• Induction of gene mutation in mammalian cells by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a chlorine disinfection by-product in drinking water.

  Mutation research 19940801

• Kinds and locations of mutations induced in the hypoxanthine-guanine phosphoribosyltransferase gene of human T-lymphocytes by 1-nitrosopyrene, including those caused by V(D)J recombinase.

  Cancer research 19940801

• Mutational spectrum of chromium(VI) in human cells.

  Mutation research 19940101

• 6-Thioguanine therapy for psoriasis causing toxic hepatic venoocclusive disease.

  Journal of the American Academy of Dermatology 19930601

• Fulminant hepatic failure after high-dose cytosine arabinoside and mitoxantrone treatment for relapse of acute myelogenous leukaemia.

  European journal of haematology 19921001

• Thioguanine used in maintenance therapy of chronic myeloid leukaemia causes non-cirrhotic portal hypertension. Results from MRC CML. II. Trial comparing busulphan with busulphan and thioguanine.

  British journal of haematology 19911001

• Daunorubicin, amsacrine, and sinus arrest.

  The Western journal of medicine 19910401

• Mutational specificity of the carcinogen 3-amino-1-methyl-5H-pyrido[4,3-b]-indole in mammalian cells.

  Carcinogenesis 19900501

• Idiopathic portal hypertension associated with cytotoxic drugs.

  Journal of clinical pathology 19900301

• Protection against isoproterenol-induced myocardial necrosis in rats by 6-mercaptopurine and 6-thioguanine or by irradiation.

  Research communications in chemical pathology and pharmacology 19890301

• Peliosis hepatis induced by 6-thioguanine administration.

  Gut 19880901

• Nonspecific corticosteroid therapy in patients receiving intra-arterial chemotherapy for hepatic metastases of colorectal origin.

  Cancer investigation 19880101

• Oesophageal varices associated with busulphan-thioguanine combination therapy for chronic myeloid leukaemia.

  Lancet (London, England) 19871107

• High-dose cytosine arabinoside and mitoxantrone: a highly effective regimen in refractory acute myeloid leukemia.

  Blood 19870301

• High-dose cytosine arabinoside, daunomycin and 6-thioguanine in relapsed or refractory acute nonlymphocytic leukemia.

  Oncology 19870101

• Induction of 6-thioguanine resistance, chromosome aberrations and SCE by dinitropyrenes in Chinese hamster ovary cells in vitro.

  Mutation research 19851201

• Drug-induced stomatocytosis and anemia during consolidation chemotherapy of childhood acute leukemia.

  The American journal of the medical sciences 19840101

• 6-thioguanine as a cause of toxic veno-occlusive disease of the liver.

  Journal of clinical pathology 19821001

• Hepatic veno-occlusive disease caused by 6-thioguanine.

  Annals of internal medicine 19820101

• Cytotoxicity and mutagenicity of the fungicides captan and folpet in cultured mammalian cells CHO/HGPRT system).

  Environmental mutagenesis 19810101

• Mutation of Chinese hamster cells by near-UV activation of promutagens.

  Mutation research 19800801

• Transient aphasia with lithium toxicity.

  Psychosomatics 19780101

• Veno-occlusive disease of the liver after chemotherapy of acute leukemia. Report of two cases.

  Annals of internal medicine 19761101

• Letter: Neurotoxicity of intrathecal chemotherapy for leukaemia.

  British medical journal 19731006

• Purine analogs as potential anticytomegalovirus agents.

  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19690901