-
Hypoxia suppresses E-cadherin and enhances matrix metalloproteinase-2 expression favoring esophageal carcinoma migration and invasion via hypoxia inducible factor-1 alpha activation.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20130101
-
Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology 20120701
-
Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis.
Cancer metastasis reviews 20120601
-
Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities.
The Journal of biological chemistry 20120413
-
Matrix metalloproteinase-9 in a unique proteoglycan form in avian embryonic growth plate cartilage.
Archives of biochemistry and biophysics 20120401
-
Changes in PSA kinetics predict metastasis- free survival in men with PSA-recurrent prostate cancer treated with nonhormonal agents: combined analysis of 4 phase II trials.
Cancer 20120315
-
Biochemical analysis of matrix metalloproteinase activation of chemokines CCL15 and CCL23 and increased glycosaminoglycan binding of CCL16.
The Journal of biological chemistry 20120217
-
Essential roles for soluble virion-associated heparan sulfonated proteoglycans and growth factors in human papillomavirus infections.
PLoS pathogens 20120201
-
Labeling and enrichment of Arabidopsis thaliana matrix metalloproteases using an active-site directed, marimastat-based photoreactive probe.
Bioorganic & medicinal chemistry 20120115
-
A network flow approach to predict drug targets from microarray data, disease genes and interactome network - case study on prostate cancer.
Journal of clinical bioinformatics 20120101
-
Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735.
PloS one 20120101
-
Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis.
PloS one 20120101
-
EMMPRIN/CD147 up-regulates urokinase-type plasminogen activator: implications in oral tumor progression.
BMC cancer 20120101
-
Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer.
PloS one 20120101
-
Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease.
EXS 20120101
-
Current knowledge on pancreatic cancer.
Frontiers in oncology 20120101
-
Stroma targeting nuclear imaging and radiopharmaceuticals.
International journal of molecular imaging 20120101
-
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.
The Journal of biological chemistry 20110930
-
EMMPRIN modulates epithelial barrier function through a MMP-mediated occludin cleavage: implications in dry eye disease.
The American journal of pathology 20110901
-
Log-scale dose response of inhibitors on a chip.
Analytical chemistry 20110815
-
An understanding of the genetic basis of asthma.
The Indian journal of medical research 20110801
-
PI3Kinase signaling in glioblastoma.
Journal of neuro-oncology 20110701
-
Epidermal growth factor receptor inhibition augments the expression of MHC class I and II genes.
Clinical cancer research : an official journal of the American Association for Cancer Research 20110701
-
Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20110401
-
Ocular neovascularization caused by herpes simplex virus type 1 infection results from breakdown of binding between vascular endothelial growth factor A and its soluble receptor.
Journal of immunology (Baltimore, Md. : 1950) 20110315
-
Targeted therapies for metastatic esophagogastric cancer.
Current treatment options in oncology 20110301
-
EGFR gene overexpression retained in an invasive xenograft model by solid orthotopic transplantation of human glioblastoma multiforme into nude mice.
Cancer investigation 20110301
-
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer.
Disease models & mechanisms 20110301
-
Extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) as a novel regulator of myogenic cell differentiation.
Journal of cellular physiology 20110101
-
New Strategies for the Next Generation of Matrix-Metalloproteinase Inhibitors: Selectively Targeting Membrane-Anchored MMPs with Therapeutic Antibodies.
Biochemistry research international 20110101
-
Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease.
Biochemistry research international 20110101
-
Downregulation of TGF-beta receptor types II and III in oral squamous cell carcinoma and oral carcinoma-associated fibroblasts.
BMC cancer 20110101
-
Functional biomarkers of musculoskeletal syndrome (MSS) for early in vivo screening of selective MMP-13 inhibitors.
Journal of pharmacological and toxicological methods 20110101
-
A meta-analysis of gemcitabine containing chemotherapy for locally advanced and metastatic pancreatic adenocarcinoma.
Journal of hematology & oncology 20110101
-
Molecular characteristics of pancreatic ductal adenocarcinoma.
Pathology research international 20110101
-
The validation of the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30) in pre-operative patients with brain tumor in China.
BMC medical research methodology 20110101
-
Zinc-chelation contributes to the anti-angiogenic effect of ellagic acid on inhibiting MMP-2 activity, cell migration and tube formation.
PloS one 20110101
-
Promising molecular targeted therapies in breast cancer.
Indian journal of pharmacology 20110101
-
Latest developments and emerging treatment options in the management of stomach cancer.
Cancer management and research 20110101
-
HIF-1α effects on angiogenic potential in human small cell lung carcinoma.
Journal of experimental & clinical cancer research : CR 20110101
-
Current immunotherapeutic approaches in pancreatic cancer.
Clinical & developmental immunology 20110101
-
Long-Term Relapse-Free Survival by Interdisciplinary Collaboration in a Patient with Metastatic Pancreatic Cancer (UICC IV).
Case reports in oncology 20110101
-
Quantitative analysis of the effect of cancer invasiveness and collagen concentration on 3D matrix remodeling.
PloS one 20110101
-
Tumor necrosis factor α-converting enzyme inhibition reverses hepatic steatosis and improves insulin sensitivity markers and surgical outcome in mice.
PloS one 20110101
-
Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations.
PloS one 20110101
-
Looking to the future: biomarkers in the management of pancreatic adenocarcinoma.
International journal of molecular sciences 20110101
-
Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System.
Clinical Medicine Insights. Oncology 20110101
-
Mining the Active Proteome of Arabidopsis thaliana.
Frontiers in plant science 20110101
-
A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma.
Neuro-oncology 20101101
-
TGF-β signaling in gingival fibroblast-epithelial interaction.
Journal of dental research 20101101
-
Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.
Cancer research 20101001
-
Matrix remodeling as stem cell recruitment event: a novel in vitro model for homing of human bone marrow stromal cells to the site of injury shows crucial role of extracellular collagen matrix.
Matrix biology : journal of the International Society for Matrix Biology 20101001
-
Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall.
Acta neuropathologica 20100801
-
Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma.
Neuroscience 20100630
-
A phase I study of the safety and pharmacokinetics of the histone deacetylase inhibitor belinostat administered in combination with carboplatin and/or paclitaxel in patients with solid tumours.
British journal of cancer 20100629
-
Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer.
Journal of mammary gland biology and neoplasia 20100601
-
A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products.
Molecular & cellular proteomics : MCP 20100501
-
Effects of metalloproteinase inhibition in a murine model of renal ischemia-reperfusion injury.
Pediatric research 20100301
-
Angiogenesis: Future of pharmacological modulation.
Indian journal of pharmacology 20100201
-
An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: actions of TNP-470, marimastat and the tubulin-binding agent Ang-510.
Biochemical and biophysical research communications 20100108
-
Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck.
Journal of biomedical science 20100101
-
Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells.
BMC cancer 20100101
-
Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice.
PloS one 20100101
-
Angiogenesis and progression in human melanoma.
Dermatology research and practice 20100101
-
Current and emerging therapies for the treatment of pancreatic cancer.
OncoTargets and therapy 20100101
-
Metalloproteinase inhibitors: status and scope from marine organisms.
Biochemistry research international 20100101
-
Cytogenetic analysis of the pathology of frozen shoulder.
International journal of shoulder surgery 20100101
-
The role of funding and policies on innovation in cancer drug development.
Ecancermedicalscience 20100101
-
Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics.
Acta orthopaedica 20091204
-
Integrin alpha(v)beta(3), metalloproteinases, and sphingomyelinase-2 mediate urokinase mitogenic effect.
Cellular signalling 20091201
-
Hydroxamates: relationships between structure and plasma stability.
Journal of medicinal chemistry 20091112
-
Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors.
The Journal of biological chemistry 20090904
-
Two phase II trials of temozolomide with interferon-alpha2b (pegylated and non-pegylated) in patients with recurrent glioblastoma multiforme.
British journal of cancer 20090818
-
In vivo efficacy of marimastat and chemoradiation in head and neck cancer xenografts.
ORL; journal for oto-rhino-laryngology and its related specialties 20090801
-
Novel investigational drugs for gastric cancer.
Expert opinion on investigational drugs 20090701
-
Matrix metalloproteinase inhibitors (MMPIs) from marine natural products: the current situation and future prospects.
Marine drugs 20090601
-
Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.
The Biochemical journal 20090428
-
Pharmacological treatment of a diffuse arteriovenous malformation of the upper extremity in a child.
The Journal of craniofacial surgery 20090301
-
Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review.
Medical science monitor : international medical journal of experimental and clinical research 20090201
-
Current perspective of TACE inhibitors: a review.
Bioorganic & medicinal chemistry 20090115
-
Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice.
BMC musculoskeletal disorders 20090101
-
Long term survivors with metastatic pancreatic adenocarcinoma treated with gemcitabine: a retrospective analysis.
Journal of hematology & oncology 20090101
-
Stereotactic radiosurgery for glioblastoma: retrospective analysis.
Radiation oncology (London, England) 20090101
-
Risedronate inhibits human osteosarcoma cell invasion.
Journal of experimental & clinical cancer research : CR 20090101
-
Chronic obstructive pulmonary disease: towards pharmacogenetics.
Genome medicine 20090101
-
Temozolomide: The evidence for its therapeutic efficacy in malignant astrocytomas.
Core evidence 20090101
-
Critical appraisal of temozolomide formulations in the treatment of primary brain tumors: patient considerations.
Cancer management and research 20090101
-
Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancer.
Journal of the National Cancer Institute 20081217
-
Modelling prognostic factors in advanced pancreatic cancer.
British journal of cancer 20080916
-
A critical role for matrix metalloproteinases in liver regeneration.
The Journal of surgical research 20080401
-
Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.
Protein science : a publication of the Protein Society 20080101
-
Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas.
Cerebrospinal fluid research 20080101
-
Experimental models of abdominal aortic aneurysms: an overview.
Current pharmaceutical design 20080101
-
Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer.
BMC cancer 20080101
-
Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains.
Journal of molecular biology 20071102
-
Diffuse glioma growth: a guerilla war.
Acta neuropathologica 20071101
-
Future therapeutic treatment of COPD: struggle between oxidants and cytokines.
International journal of chronic obstructive pulmonary disease 20070901
-
MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells.
British journal of cancer 20070806
-
Canadian recommendations for the treatment of glioblastoma multiforme.
Current oncology (Toronto, Ont.) 20070601
-
A preclinical evaluation of pemetrexed and irinotecan combination as second-line chemotherapy in pancreatic cancer.
British journal of cancer 20070507
-
Molecular tools for metalloprotease sub-proteome generation.
Journal of biotechnology 20070430
-
Neutralization of the haemorrhagic activities of viperine snake venoms and venom metalloproteinases using synthetic peptide inhibitors and chelators.
Toxicon : official journal of the International Society on Toxinology 20070401
-
Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat.
European journal of pharmacology 20070315
-
Towards bioreductively activated prodrugs: Fe(III) complexes of hydroxamic acids and the MMP inhibitor marimastat.
Journal of inorganic biochemistry 20070301
-
Studies of a cobalt(III) complex of the MMP inhibitor marimastat: a potential hypoxia-activated prodrug.
Chemistry (Weinheim an der Bergstrasse, Germany) 20070101
-
Extracellular matrix metalloproteinase inducer up-regulates the urokinase-type plasminogen activator system promoting tumor cell invasion.
Cancer research 20070101
-
High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis.
Arthritis research & therapy 20070101
-
Impact of phase II trials with progression-free survival as end-points on survival-based phase III studies in patients with anaplastic gliomas.
BMC cancer 20070101
-
Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study.
Arthritis research & therapy 20070101
-
Proteinases in the joint: clinical relevance of proteinases in joint destruction.
Arthritis research & therapy 20070101
-
Breast tumour angiogenesis.
Breast cancer research : BCR 20070101
-
Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model.
American journal of physiology. Gastrointestinal and liver physiology 20061201
-
Role of erlotinib in the management of pancreatic cancer.
Therapeutics and clinical risk management 20061201
-
Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status.
Journal of neuro-oncology 20061001
-
Biological targets for therapeutic interventions in COPD: clinical potential.
International journal of chronic obstructive pulmonary disease 20060901
-
Temozolomide chemotherapy in patients with recurrent malignant gliomas.
Journal of Korean medical science 20060801
-
Randomized, double-blind, placebo-controlled trial of marimastat in glioblastoma multiforme patients following surgery and irradiation.
Journal of neuro-oncology 20060701
-
Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials.
British journal of cancer 20060424
-
Towards third generation matrix metalloproteinase inhibitors for cancer therapy.
British journal of cancer 20060410
-
Raltitrexed-eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer.
British journal of cancer 20060327
-
Anti-angiogenesis therapy in pancreatic carcinoma.
JOP : Journal of the pancreas 20060309
-
The importance of estimating the therapeutic index in the development of matrix metalloproteinase inhibitors.
Cardiovascular research 20060215
-
TNF-alpha as a target for anti-asthma therapy.
Clinical science (London, England : 1979) 20060201
-
Plasma matrix metalloproteinases 7 and 9 in patients with metastatic breast cancer treated with marimastat or placebo: Eastern Cooperative Oncology Group trial E2196.
Clinical breast cancer 20060201
-
Gastric cancer. Treatment of advanced disease and new drugs.
Frontiers in bioscience : a journal and virtual library 20050901
-
[Role of extracellular matrix degradation enzyme for glioma invasion].
Nihon rinsho. Japanese journal of clinical medicine 20050901
-
[Inhibition of cellular adhesion and invasion in gliomas].
Nihon rinsho. Japanese journal of clinical medicine 20050901
-
[Research on the antimetastatic agents].
Nihon rinsho. Japanese journal of clinical medicine 20050901
-
[Anti-angiogenesis treatment for brain tumors--present and future].
Nihon rinsho. Japanese journal of clinical medicine 20050901
-
Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases.
Experimental cell research 20050715
-
Marimastat in the treatment of patients with biochemically relapsed prostate cancer: a prospective randomized, double-blind, phase I/II trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 20050615
-
The effect of marimastat, a metalloprotease inhibitor, on allergen-induced asthmatic hyper-reactivity.
Toxicology and applied pharmacology 20050601
-
Phase I trial of the matrix metalloproteinase inhibitor marimastat combined with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 20050501
-
Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development.
Experimental cell research 20050401
-
Docetaxel in the management of advanced pancreatic cancer.
Seminars in oncology 20050401
-
Analysis of combination anti-angiogenesis therapy on markers of coagulation, platelet activation and angiogenesis in patients with advanced cancer.
Cancer letters 20050310
-
Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts.
The Journal of pharmacology and experimental therapeutics 20050301
-
Macrophage elastase (MMP-12): a pro-inflammatory mediator?
Memorias do Instituto Oswaldo Cruz 20050301
-
Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3.
Journal of vascular research 20050101
-
A matrix metalloproteinase inhibitor to treat unresectable cholangiocarcinoma.
HPB : the official journal of the International Hepato Pancreato Biliary Association 20050101
-
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.
The Journal of biological chemistry 20041203
-
Randomized phase III trial of marimastat versus placebo in patients with metastatic breast cancer who have responding or stable disease after first-line chemotherapy: Eastern Cooperative Oncology Group trial E2196.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20041201
-
Phase II trial of the antiangiogenic agent IM862 in metastatic renal cell carcinoma.
British journal of cancer 20041101
-
Phase II study of a triplet regimen in advanced colorectal cancer using methotrexate, oxaliplatin and 5-fluorouracil.
British journal of cancer 20041018
-
Molecular neuro-oncology and the development of targeted therapeutic strategies for brain tumors. Part 3: brain tumor invasiveness.
Expert review of anticancer therapy 20041001
-
SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.
Cancer research 20040901
-
Combination antiangiogenesis therapy with marimastat, captopril and fragmin in patients with advanced cancer.
British journal of cancer 20040705
-
Zymographic detection and clinical correlations of MMP-2 and MMP-9 in breast cancer sera.
British journal of cancer 20040405
-
Involvement of matrix metalloproteinases in the onset of dentin mineralization.
European journal of oral sciences 20040401
-
Novel therapies for pancreatic adenocarcinoma.
Current gastroenterology reports 20040401
-
ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma.
British journal of cancer 20040308
-
Matrix metalloproteinase inhibitors.
Current oncology reports 20040301
-
A phase I and pharmacological study of the matrix metalloproteinase inhibitor BB-3644 in patients with solid tumours.
British journal of cancer 20040223
-
Crystal structure of the catalytic domain of human ADAM33.
Journal of molecular biology 20040102
-
Recent translational research: antiangiogenic therapy for breast cancer - where do we stand?
Breast cancer research : BCR 20040101
-
Synthesis of marimastat and a marimastat conjugate for affinity chromatography and surface plasmon resonance studies.
Bioconjugate chemistry 20040101
-
[Expression of matrix metalloproteinases in patients with malignant tumors].
Medicina (Kaunas, Lithuania) 20040101
-
Targeting angiogenesis: a review of angiogenesis inhibitors in the treatment of lung cancer.
Lung cancer (Amsterdam, Netherlands) 20031201
-
Levels and molecular forms of MMP-7 (matrilysin-1) and MMP-8 (collagenase-2) in diseased human peri-implant sulcular fluid.
Journal of periodontal research 20031201
-
Comparison of prognostic factors in patients in phase I trials of cytotoxic drugs vs new noncytotoxic agents.
British journal of cancer 20031006
-
[Angiogenesis and metastasis in colorectal cancer].
Nihon rinsho. Japanese journal of clinical medicine 20030901
-
Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 20030828
-
Structure--activity relationships of azasugar-based MMP/ADAM inhibitors.
Bioorganic & medicinal chemistry letters 20030818
-
Angiogenesis inhibitors under study for the treatment of lung cancer.
Lung cancer (Amsterdam, Netherlands) 20030801
-
A phase I and pharmacologic study of the combination of marimastat and paclitaxel in patients with advanced malignancy.
Medical science monitor : international medical journal of experimental and clinical research 20030801
-
Anti-angiogenesis in cancer therapy.
Seminars in oncology nursing 20030801
-
In vitro and in vivo endochondral bone formation models allow identification of anti-angiogenic compounds.
The American journal of pathology 20030701
-
Functional characterization of adherent synovial fluid cells in rheumatoid arthritis: destructive potential in vitro and in vivo.
Arthritis and rheumatism 20030701
-
The interaction of metal ions and Marimastat with matrix metalloproteinase 9.
Journal of inorganic biochemistry 20030601
-
Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats.
Arthritis and rheumatism 20030601
-
Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura.
British journal of cancer 20030519
-
Emerging drugs for non-small cell lung cancer.
Expert opinion on emerging drugs 20030501
-
Serum markers of matrix turnover as predictors for the evolution of colorectal cancer metastasis under chemotherapy.
British journal of cancer 20030422
-
Marimastat may not improve survival over placebo following induction therapy for small-cell lung cancer.
Cancer treatment reviews 20030401
-
A novel matrix metalloproteinase inhibitor, FYK-1388 suppresses tumor growth, metastasis and angiogenesis by human fibrosarcoma cell line.
International journal of oncology 20030201
-
Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201
-
[Angiogenesis research--quo vadis?].
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20030201
-
Randomised double blind placebo control study of adjuvant treatment with the metalloproteinase inhibitor, Marimastat in patients with inoperable colorectal hepatic metastases: significant survival advantage in patients with musculoskeletal side-effects.
Anticancer research 20030101
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20030101
-
[Matrix metalloproteinases and atherosclerosis. Therapeutic aspects].
Annales de biologie clinique 20030101
-
Advances in molecular therapies in patients with brain tumors.
Cancer control : journal of the Moffitt Cancer Center 20030101
-
Drugs in development: bisphosphonates and metalloproteinase inhibitors.
Arthritis research & therapy 20030101
-
Marimastat: BB 2516, TA 2516.
Drugs in R&D 20030101
-
Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition.
Clinical & experimental metastasis 20030101
-
Phase II study of high central dose Gamma Knife radiosurgery and marimastat in patients with recurrent malignant glioma.
International journal of radiation oncology, biology, physics 20021201
-
Gemcitabine in the treatment of advanced pancreatic cancer: a comparative analysis of randomized trials.
Seminars in oncology 20021201
-
Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: a trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20021115
-
Phase II study of marimastat (BB-2516) in malignant melanoma: a clinical and tumor biopsy study of the National Cancer Institute of Canada Clinical Trials Group.
Investigational new drugs 20021101
-
Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer.
Cancer research 20021015
-
Matrix metalloproteinase inhibition reduces adventitial thickening and collagen accumulation following balloon dilation.
Cardiovascular research 20020901
-
Matrix metalloproteinase inhibitor therapy to prevent complications as well as therapy for Ehler-Danlos syndrome.
Medical hypotheses 20020901
-
A synthetic matrix metalloproteinase inhibitor prevents squamous carcinoma cell proliferation by interfering with epidermal growth factor receptor autocrine loops.
International journal of cancer 20020810
-
Metalloproteinase inhibitor attenuates neointima formation and constrictive remodeling after angioplasty in rats: augmentative effect of alpha(v)beta(3) receptor blockade.
Atherosclerosis 20020801
-
Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials.
Annals of surgical oncology 20020801
-
A randomized phase II pilot trial of adjuvant marimastat in patients with early-stage breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology 20020801
-
Integrin alpha(v)beta6-associated ERK2 mediates MMP-9 secretion in colon cancer cells.
British journal of cancer 20020729
-
A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer.
British journal of cancer 20020715
-
Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration.
Journal of vascular surgery 20020701
-
Matrix metalloproteinase inhibitor, marimastat, decreases peritoneal spread of gastric carcinoma in nude mice.
Japanese journal of cancer research : Gann 20020701
-
Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial.
British journal of cancer 20020617
-
Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme.
Journal of medicinal chemistry 20020523
-
[New drugs in bronchial cancer].
Presse medicale (Paris, France : 1983) 20020511
-
Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases.
The Journal of biological chemistry 20020329
-
Differential effects between marimastat, a TNF-alpha converting enzyme inhibitor, and anti-TNF-alpha antibody on murine models for sepsis and arthritis.
Cytokine 20020321
-
[Progress in diagnosis and treatment of lung cancer].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20020320
-
Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020301
-
Chemokine stimulation of monocyte matrix metalloproteinase-9 requires endogenous TNF-alpha.
European journal of immunology 20020201
-
Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer.
Seminars in oncology 20020201
-
Exploiting molecular targets in pancreatic cancer.
Hematology/oncology clinics of North America 20020201
-
Involvement of matrix metalloproteinase type-3 in hepatocyte growth factor-induced invasion of human hepatocellular carcinoma cells.
International journal of cancer 20020110
-
Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 20020103
-
Gastroesophageal cancer, palmar fasciitis and a matrix metalloproteinase inhibitor.
Internal medicine journal 20020101
-
Ectodomain shedding of cystinyl aminopeptidase from human placental membranes.
Placenta 20020101
-
Inhibition of cervical lymph node metastasis by marimastat (BB-2516) in an orthotopic oral squamous cell carcinoma implantation model.
Clinical & experimental metastasis 20020101
-
The role of the matrix metalloproteinases during in vitro vessel formation.
Angiogenesis 20020101
-
Angiogenesis inhibitors in the treatment of lung cancer.
Lung cancer (Amsterdam, Netherlands) 20011201
-
A phase II trial of marimastat in advanced pancreatic cancer.
British journal of cancer 20011201
-
Calmodulin inhibitors trigger the proteolytic processing of membrane type-1 matrix metalloproteinase, but not its shedding in glioblastoma cells.
The Biochemical journal 20011015
-
[Tumor dormancy therapy for hepatocellular carcinoma].
Nihon rinsho. Japanese journal of clinical medicine 20011001
-
Marimastat therapy as adjuvant to selective embolization in skeletal metastases of differentiated thyroid carcinoma.
Clinical endocrinology 20010901
-
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Journal of medicinal chemistry 20010802
-
Matrix metalloproteinase inhibition of pancreatic cancer: matching mechanism of action to clinical trial design.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010801
-
Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010801
-
Expression of matrix metalloproteinases and the metastasis-associated gene S100A4 in human neuroblastoma and primitive neuroectodermal tumor cells.
Journal of pediatric surgery 20010701
-
Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 20010604
-
[Extracellular matrix degradation enzymes: important factors in liver metastasis of colorectal cancer and good targets for anticancer metastatic therapy].
Nihon Geka Gakkai zasshi 20010501
-
Production of MMPs in human cerebral endothelial cells and their role in shedding adhesion molecules.
Journal of neuropathology and experimental neurology 20010401
-
[Matrix metalloproteinase in human gastric carcinoma].
Nihon rinsho. Japanese journal of clinical medicine 20010401
-
[Matrix metalloproteinase inhibitors for therapy of cancer].
Nihon rinsho. Japanese journal of clinical medicine 20010401
-
Alternatives to chemotherapy and radiotherapy in the treatment of small cell lung cancer.
Seminars in oncology 20010401
-
Development of matrix metalloproteinase inhibitors in cancer therapy.
Journal of the National Cancer Institute 20010207
-
Angiogenesis: regulators and clinical applications.
Biochemical pharmacology 20010201
-
Oral matrix metalloproteinase inhibition and arterial remodeling after balloon dilation: an intravascular ultrasound study in the pig.
Circulation 20010116
-
Matrix metalloproteinases in lung biology.
Respiratory research 20010101
-
Therapeutic angiogenesis inhibitors in the treatment of cancer.
Advances in internal medicine 20010101