15500-66-0 | Pancuronium dibromide

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%(HPLC)	in stock	$45.00	$32.00
25mg	98%(HPLC)	in stock	$130.00	$91.00
50mg		in stock	$258.00	$180.00
100mg	98%(HPLC)	in stock	$381.00	$267.00
1g	≥99%	in stock	$3,605.00	$2,524.00

Description

• Catalog Number: AI37407
• Chemical Name: Pancuronium dibromide
• CAS Number: 15500-66-0
• Molecular Formula: C35H60Br2N2O4
• Molecular Weight: 732.6699
• MDL Number: MFCD00079223
• SMILES: CC(=O)O[C@H]1C[C@@H]2CCC3[C@@H](C2(CC1[N+]1(C)CCCCC1)C)CCC1([C@H]3CC(C1OC(=O)C)[N+]1(C)CCCCC1)C.[Br-].[Br-]

Computed Properties

• Complexity: 1000
• Covalently-Bonded Unit Count: 3
• Defined Atom Stereocenter Count: 10
• Heavy Atom Count: 43
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6

Literature

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  PLoS medicine 20070401

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  Journal of the Egyptian Society of Parasitology 20070401

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• Local anesthetic infiltration of the wound for supplemental postoperative pain management in a pediatric liver transplant patient.

  Paediatric anaesthesia 20070101

• A modification of the kinetic determination of pancuronium bromide based on its inhibitory effect on cholinesterase.

  Journal of clinical laboratory analysis 20070101

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  Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 20070101

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  European journal of applied physiology 20060801

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• Simultaneous determination of pancuronium, vecuronium and their related compounds using LC-ESI-MS.

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  Middle East journal of anaesthesiology 20051001

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• Cardiac anesthesia management of a patient with Bartter's syndrome.

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  European journal of clinical pharmacology 20050501

• Accidental epidural injection of pancuronium.

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  Anesthesiology 20041201

• Effects of nandrolone decanoate on the neuromuscular junction of rats submitted to swimming.

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• Perioperative management of pacemaker implantation for congenital complete heart block.

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• On death row, a battle over the fatal cocktail: critics say executions amount to torture.

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• Chromosome instability in T-cells cultured in the presence of pancuronium or fentanyl.

  Acta anaesthesiologica Scandinavica 20040901

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• Characterization of embryonic cardiac pacemaker and atrioventricular conduction physiology in Xenopus laevis using noninvasive imaging.

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• The effects of vagal stimulation on laryngeal vascular resistance and intraluminal pressure in the dog.

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• Thermogenesis elicited by skin cooling in anaesthetized rats: lack of contribution of the cerebral cortex.

  The Journal of physiology 20040301

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• Effect of the respiratory-related bronchial rhythmic constriction on alveolar ventilation in the dog.

  Respiratory physiology & neurobiology 20031216

• Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells.

  Molecular pharmacology 20031201

• Anesthetic management for a hypertensive patent ductus arteriosus (PDA) closure in a patient with surgically uncorrectable long-segment right pulmonary artery hypoplasia and a ventricular septal defect.

  Journal of cardiothoracic and vascular anesthesia 20031201

• Who--and how--to kill are focus of US death penalty cases. Questions about prisoners' mental competence and use of pancuronium bromide ignite recent controversy.

  Lancet (London, England) 20031018

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  The New York times on the Web 20031007

• Pancuronium bromide, a non-depolarizing muscle relaxant which promotes apoptosis of blood lymphocytes in vitro.

  Acta anaesthesiologica Scandinavica 20031001

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• Diverse range of fixed positional deformities and bone growth restraint provoked by flaccid paralysis in embryonic chicks.

  International journal of experimental pathology 20030801

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  Anesthesiology 20030701

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  American journal of veterinary research 20030601

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  Anesthesiology 20030501

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  Experimental physiology 20030501

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  Paediatric anaesthesia 20030501

• Prospective randomised double-blind comparative study of rocuronium and pancuronium in adult patients scheduled for elective 'fast-track' cardiac surgery involving hypothermic cardiopulmonary bypass.

  Anaesthesia 20030301

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  Anesthesiology 20030101

• Effect of neuromuscular blockade on energy expenditure in patients with severe head injury.

  JPEN. Journal of parenteral and enteral nutrition 20030101

• National survey of the use of sedating drugs, neuromuscular blocking agents, and reversal agents in the intensive care unit.

  Journal of intensive care medicine 20030101

• Sustained firing of alpha and gamma hind limb motoneurons induced by stimulation of the pudendal nerve.

  Journal of neurophysiology 20021201

• Preemptive analgesia in rhegmatogenous retinal detachment surgery: is it effective?

  Retina (Philadelphia, Pa.) 20021001

• Respiratory arrest in a child after flushing of pancuronium from the deadspace of intravenous cannula.

  JPMA. The Journal of the Pakistan Medical Association 20021001

• Tachyphylaxis associated with continuous cisatracurium versus pancuronium therapy.

  Pharmacotherapy 20020701

• An isolated, antegrade, perfused, peroneal nerve anterior tibialis muscle model in the rat: a novel model developed to study the factors governing the time course of action of neuromuscular blocking agents.

  Anesthesiology 20020401

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  Bioorganic & medicinal chemistry letters 20020311

• Validation of a high-performance liquid chromatography method for the determination of pancuronium in Pavulon injections.

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  Anesthesiology 20020301

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  European journal of pharmacology 20020301

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  Ginekologia polska 20020201

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  Journal of analytical toxicology 20020101

• [Hemostatic profile of women using low-dose oral contraceptive Mercilon. (Preliminary report)].

  Akusherstvo i ginekologiia 20020101

• The kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium.

  Molecular pharmacology 20011001

• Anaesthetic management of baboons undergoing heterotopic porcine cardiac xenotransplantation.

  Veterinary research communications 20010501

• Activation of skeletal muscle afferents evokes release of glutamate in the subretrofacial nucleus (SRF) of cats.

  Brain research 20010316

• Open channel and competitive block of nicotinic receptors by pancuronium and atracurium.

  European journal of pharmacology 20010209

• Impact of the initial doses of rocuronium and pancuronium on subsequent maintenance for neuromuscular block.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010201

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  Der Anaesthesist 20010201

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  Revista espanola de anestesiologia y reanimacion 20010201

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  The Journal of pediatrics 19990801

• Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.

  The American journal of physiology 19990401

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  British journal of pharmacology 19981101

• Anaphylactoid reaction induced by pancuronium during general anaesthesia.

  European journal of anaesthesiology 19980901

• Administration of a neuromuscular blocking agent and a narcotic agent mimicking posterior urethral valves.

  The Western journal of medicine 19980301

• Paralysis has no effect on chest wall and respiratory system mechanics of mechanically ventilated, sedated patients.

  Intensive care medicine 19951001

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  Pharmacotherapy 19950101

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• Prolonged weakness after the withdrawal of atracurium.

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• Neuromuscular disorder in intensive care unit patients treated with pancuronium bromide. Occurrence in a cluster group of seven patients and two sporadic cases, with electrophysiologic and histologic examination.

  Chest 19940701

• Activation of brain acetylcholine receptors by neuromuscular blocking drugs. A possible mechanism of neurotoxicity.

  Anesthesiology 19940501

• Waiting time after non-depolarizing relaxants alter muscle fasciculation response to succinylcholine.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 19940301

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  Anesthesia and analgesia 19931101

• Comparison of propofol with thiopentone for treatment of bupivacaine-induced seizures in rats.

  British journal of anaesthesia 19931101

• [A case of motor neuropathy with pyramidal sign due to prolonged administration of high dose of pancuronium bromide (Myoblock)].

  Rinsho shinkeigaku = Clinical neurology 19930601

• Suxamethonium myalgia: an ethnic comparison with and without pancuronium pretreatment.

  Anaesthesia 19930501

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  Acta anaesthesiologica Scandinavica 19930501

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  Revue neurologique 19930101

• Prolonged postpancuronium paralysis.

  Critical care medicine 19920901

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  Nihon hoigaku zasshi = The Japanese journal of legal medicine 19920801

• Alfentanil combined with vecuronium or pancuronium: haemodynamic implications.

  Acta anaesthesiologica Scandinavica 19920701

• [Neuromyopathy induced by halothane anesthesia and muscle relaxants for status asthmaticus--report of 2 patients].

  Rinsho shinkeigaku = Clinical neurology 19920301

• Pancuronium-induced prolonged neuromuscular blockade.

  Critical care medicine 19911201

• Isorhythmic atrioventricular dissociation following pancuronium.

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  Neurology 19910601

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  Masui. The Japanese journal of anesthesiology 19910201

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  Revue neurologique 19910101

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  Anesthesiology 19900201

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  Annales francaises d'anesthesie et de reanimation 19890101

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  Pharmacotherapy 19890101

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  Canadian journal of anaesthesia = Journal canadien d'anesthesie 19880501

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  British journal of anaesthesia 19880301

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  Pediatrics 19880301

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  Annales francaises d'anesthesie et de reanimation 19880101

• Muscle atrophy in severe exacerbation of asthma requiring mechanical ventilation.

  Respiration; international review of thoracic diseases 19880101

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  Anaesthesia 19871201

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  Anesthesia and analgesia 19871101

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  Anesthesiology 19871001

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  Der Anaesthesist 19870801

• Bradycardia associated with the use of vecuronium. A comparative study with pancuronium with and without glycopyrronium.

  Anaesthesia 19870201

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  The Journal of pediatrics 19861101

• Cardiac arrest immediately after vecuronium.

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• Asystole associated with vecuronium.

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  Anesthesiology 19860801

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  Anesthesiology 19860401

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  The American journal of psychiatry 19851101

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  Lancet (London, England) 19850803

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  Anesthesiology 19850601

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  Clinical neurology and neurosurgery 19850101

• Rate of onset of good intubating conditions, respiratory depression and hand muscle paralysis after vecuronium.

  British journal of anaesthesia 19840901

• Severe hypertension and tachycardia associated with pancuronium bromide in a patient with asymptomatic pheochromocytoma.

  Hinyokika kiyo. Acta urologica Japonica 19840501

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  Revista espanola de anestesiologia y reanimacion 19840101

• Attenuation of fentanyl-induced truncal rigidity.

  Anesthesiology 19830601

• Recovery of neuromuscular function in the perfused rat diaphragm after succinylcholine and pancuronium blockade.

  Anesthesiology 19830501

• Comparison of isoflurane and halothane when used to control intraoperative hypertension in patients undergoing coronary artery bypass surgery.

  Anesthesia and analgesia 19830101

• Supraventricular tachycardia following pancuronium.

  British journal of anaesthesia 19821101

• Prolonged postoperative apnea complicating gynecologic surgery; atypical cholinesterase and myasthenia gravis.

  American journal of obstetrics and gynecology 19820501

• Prevention of rigidity during fentanyl--oxygen induction of anesthesia.

  Anesthesiology 19811001

• Severe hypertension associated with pancuronium in a patient with a phaeochromocytoma.

  Canadian Anaesthetists' Society journal 19810701

• Reduction of post-suxamethonium pain by pretreatment with four non-depolarizing agents.

  British journal of anaesthesia 19810501

• Haemodynamic responses to antagonism of pancuronium and alcuronium block.

  Acta anaesthesiologica Scandinavica 19810201

• Cardiovascular effects of pancuronium in patients anaesthetized with enflurane and fluroxene.

  Canadian Anaesthetists' Society journal 19810101

• Tricyclic antidepressants and cardiac arrhythmias during halothane-pancuronium anesthesia.

  Anesthesia progress 19810101

• Motor neuropathy associated with cimetidine.

  British medical journal 19801011

• Masseter spasm after pancuronium.

  Anesthesia and analgesia 19800701

• Postoperative muscle pains and suxamethonium.

  British journal of anaesthesia 19800201

• Relation of precurarization to suxamethonium to provide ease of intubation and to prevent post-suxamethonium muscle pains.

  Canadian Anaesthetists' Society journal 19790301

• Dose-related tachycardia induced by pancuronium during balanced anaesthesia with and without droperidol.

  British journal of anaesthesia 19790201

• Anesthesia related muscle paralysis in renal failure.

  Clinical nephrology 19780701

• Severe hypertension assoiated with pancuronium bromide.

  Anesthesia and analgesia 19780101

• Comparison of morphine and ketamine anesthetic technics for coronary surgery: a randomized study.

  Southern medical journal 19780101

• Comparative effects of nondepolarizing muscle relaxants on succinycholine-induced fasciculations and postoperative pain.

  Southern medical journal 19770901

• Muscle fibrillation following thiopentone and pancuronium bromide. An association with metachromatic leucodystrophy.

  Anaesthesia 19770101

• [Study of a case of prolonged apnea due to pancuronium bromide and resistant to anticholinesterase treatment].

  Minerva anestesiologica 19750401

• 'Precurarization' using pancuronium.

  Anesthesia and analgesia 19750101

• Ketamine-pancuronium-narcotic technic for cardiovascular surgery in infants--a comparative study.

  Anesthesia and analgesia 19750101

• Hemodynamic interaction between pancuronium and morphine.

  Anesthesiology 19740301

• [Arhythmia inducing action of pancuronium in patients under halothane].

  Anesthesie, analgesie, reanimation 19730101

• Prolonged coma after tetanus.

  British medical journal 19720205

• Clinical appraisal of pancuronium bromide for the aged patient.

  Anesthesia and analgesia 19720101

• Abnormal responses to muscle relaxants in a patient with Von Recklinghausen's disease (multiple neurofibromatosis).

  British journal of anaesthesia 19700801

• The role of the non-depolarizing drugs in the prevention of suxamethonium bradycardia.

  British journal of anaesthesia 19700701