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Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis.
Archives of toxicology 20161201
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Structure-dependent inhibition of the human α1β2γ2 GABAA receptor by piperazine derivatives: A novel mode of action.
Neurotoxicology 20151201
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Estrogenic effects and their action mechanism of the major active components of party pill drugs.
Toxicology letters 20121115
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Piperazine compounds as drugs of abuse.
Drug and alcohol dependence 20120501
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1-(4,5,6,7-Tetra-hydro-thieno[3,2-c]pyridin-5-yl)-2-{4-[3-(trifluoro-meth-yl)phen-yl]piperazin-1-yl}ethanone.
Acta crystallographica. Section E, Structure reports online 20120501
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Determination of piperazine-type stimulants in human urine by means of microextraction in packed sorbent and high performance liquid chromatography-diode array detection.
Journal of pharmaceutical and biomedical analysis 20120305
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Rapid determination of piperazine-type stimulants in human urine by microextraction in packed sorbent after method optimization using a multivariate approach.
Journal of chromatography. A 20120127
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Microcrystalline identification of selected designer drugs.
Forensic science international 20120110
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Simultaneous determination of N-benzylpiperazine and 1-(3-trifluoromethylphenyl)piperazine in rat plasma by HPLC-fluorescence detection and its application to monitoring of these drugs.
Biomedical chromatography : BMC 20120101
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Acute oral toxicity evaluations of some zinc(II) complexes derived from 1-(2-salicylaldiminoethyl)piperazine Schiff bases in rats.
International journal of molecular sciences 20120101
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Structural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico study.
PloS one 20120101
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Subjective effects in humans following administration of party pill drugs BZP and TFMPP alone and in combination.
Drug testing and analysis 20110901
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An analysis of legal highs: do they contain what it says on the tin?
Drug testing and analysis 20110901
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Determining the subjective and physiological effects of BZP combined with TFMPP in human males.
Psychopharmacology 20110401
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HPLC determination of methylphenidate and its metabolite, ritalinic acid, by high-performance liquid chromatography with peroxyoxalate chemiluminescence detection.
Analytical and bioanalytical chemistry 20110401
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Mephedrone (4-methylmethcathinone)-related deaths.
Journal of analytical toxicology 20110401
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The clinical toxicology of the designer 'party pills' benzylpiperazine and trifluoromethylphenylpiperazine.
Clinical toxicology (Philadelphia, Pa.) 20110301
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Effects of trifluoromethylphenylpiperazine (TFMPP) on interhemispheric communication.
Psychopharmacology 20110201
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Development of a rapid LC-MS/MS method for direct urinalysis of designer drugs.
Drug testing and analysis 20110101
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Current awareness of piperazines: pharmacology and toxicology.
Drug testing and analysis 20110101
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Trazodone, meta-chlorophenylpiperazine (an hallucinogenic drug and trazodone metabolite), and the hallucinogen trifluoromethylphenylpiperazine cross-react with the EMIT®II ecstasy immunoassay in urine.
Journal of analytical toxicology 20101101
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Detection of 1-benzylpiperazine, 1-(3-trifluoromethylphenyl)-piperazine, and 1-(3-chlorophenyl)-piperazine in 3,4-methylenedioxymethamphetamine-positive urine samples.
Journal of analytical toxicology 20101001
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Randomised double-blind, placebo-controlled trial of the effects of the 'party pills' BZP/TFMPP alone and in combination with alcohol.
Journal of psychopharmacology (Oxford, England) 20100901
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Validation of an LC-MS method for the detection and quantification of BZP and TFMPP and their hydroxylated metabolites in human plasma and its application to the pharmacokinetic study of TFMPP in humans.
Journal of forensic sciences 20100901
-
Determining the subjective effects of TFMPP in human males.
Psychopharmacology 20100801
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3-Chloro-6-{4-[3-(trifluoro-meth-yl)phen-yl]piperazin-1-yl}pyridazine.
Acta crystallographica. Section E, Structure reports online 20100301
-
Piperazines: a new class of drug of abuse has landed in Hong Kong.
Hong Kong medical journal = Xianggang yi xue za zhi 20100201
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Differences in harm from legal BZP/TFMPP party pills between North Island and South Island users in New Zealand: a case of effective industry self-regulation?
The International journal on drug policy 20100101
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Legal highs toxicity--symptomatology and clinical diagnosis in case series.
Przeglad lekarski 20100101
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'Party pill' drugs--BZP and TFMPP.
The New Zealand medical journal 20091211
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In vivo interactions between BZP and TFMPP (party pill drugs).
The New Zealand medical journal 20090925
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Differentiation of the regioisomeric 2-, 3-, and 4-trifluoromethylphenylpiperazines (TFMPP) by GC-IRD and GC-MS.
Forensic science international 20090701
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Metabolic interactions with piperazine-based 'party pill' drugs.
The Journal of pharmacy and pharmacology 20090701
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Activation of serotonin 5-HT1-receptors decreased gripping-induced immobility episodes in taiep rats.
Neuroscience letters 20090109
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Dissociative and sympathomimetic toxicity associated with recreational use of 1-(3-trifluoromethylphenyl) piperazine (TFMPP) and 1-benzylpiperzine (BZP).
Journal of medical toxicology : official journal of the American College of Medical Toxicology 20081201
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Patterns of benzylpiperazine/trifluoromethylphenylpiperazine party pill use and adverse effects in a population sample in New Zealand.
Drug and alcohol review 20081101
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Serotonin transduction cascades mediate variable changes in pyloric network cycle frequency in response to the same modulatory challenge.
Journal of neurophysiology 20080601
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Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects.
The Journal of pharmacology and experimental therapeutics 20080501
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Investigation of the first deaths in the United Kingdom involving the detection and quantitation of the piperazines BZP and 3-TFMPP.
Journal of analytical toxicology 20080301
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[1-benzylpiperazine (BZP) and 1-(3-trifluorométhylphényl)pipérazine (TFMPP): emergence of two agents which lead to misuse].
Annales pharmaceutiques francaises 20080301
-
Detection of 1-benzylpiperazine and 1-(3-trifluoromethylphenyl)-piperazine in urine analysis specimens using GC-MS and LC-ESI-MS.
Journal of analytical toxicology 20080101
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The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.
Bioorganic & medicinal chemistry 20071115
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Benzylpiperazine: a drug of abuse?
Journal of psychopharmacology (Oxford, England) 20071101
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MDMA-like behavioral effects of N-substituted piperazines in the mouse.
Pharmacology, biochemistry, and behavior 20071101
-
Interaction of amphetamines and related compounds at the vesicular monoamine transporter.
The Journal of pharmacology and experimental therapeutics 20061001
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Effects of (Z)-3-hexenol, a major component of green odor, on anxiety-related behavior of the mouse in an elevated plus-maze test and biogenic amines and their metabolites in the brain.
Behavioural brain research 20060130
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Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior.
The Journal of pharmacology and experimental therapeutics 20050701
-
Metabolism of designer drugs of abuse.
Current drug metabolism 20050601
-
Development of simultaneous gas chromatography-mass spectrometric and liquid chromatography-electrospray ionization mass spectrometric determination method for the new designer drugs, N-benzylpiperazine (BZP), 1-(3-trifluoromethylphenyl)piperazine (TFMPP) and their main metabolites in urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050525
-
Differential effects of 5-HT2C receptor ligands on place conditioning and locomotor activity in rats.
European journal of pharmacology 20050516
-
N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA, or 'Ecstasy').
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050301
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Simultaneous separation of different types of amphetamine and piperazine designer drugs by capillary electrophoresis with a chiral selector.
Journal of forensic sciences 20050301
-
Reinforcing and discriminative stimulus effects of 1-benzylpiperazine and trifluoromethylphenylpiperazine in rhesus monkeys.
Drug and alcohol dependence 20050214
-
Isolation, identification and excretion profile of the principal urinary metabolite of the recently banned designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP) in rats.
Xenobiotica; the fate of foreign compounds in biological systems 20050101
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Discriminative stimulus effects of ethanol in rats using a three-choice ethanol-midazolam-water discrimination.
Behavioural pharmacology 20041201
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Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Naunyn-Schmiedeberg's archives of pharmacology 20040801
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Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury.
Pain 20040301
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Anxiogenic effects in the rat elevated plus-maze of 5-HT(2C) agonists into ventral but not dorsal hippocampus.
Behavioural pharmacology 20040201
-
Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor.
European journal of pharmacology 20040126
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Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP). In vivo studies in Wistar and Dark Agouti rats as well as in vitro studies in human liver microsomes.
Biochemical pharmacology 20040115
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Common drugs of abuse--Part II.
The Journal of practical nursing 20040101
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New designer drug 1-(3-trifluoromethylphenyl) piperazine (TFMPP): gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry studies on its phase I and II metabolism and on its toxicological detection in rat urine.
Journal of mass spectrometry : JMS 20030901
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Behavioural evidence of agonist-like effect of isoteoline at 5-HT1B serotonergic receptors in mice.
The Journal of pharmacy and pharmacology 20030101
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Involvement of 5-HT(2A/2B/2C) receptors on memory formation: simple agonism, antagonism, or inverse agonism?
Cellular and molecular neurobiology 20021201
-
Effects of fluoxetine and TFMPP on spontaneous seizures in rats with pilocarpine-induced epilepsy.
Epilepsia 20021101
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Role of serotonin, gamma-aminobutyric acid, and glutamate in the behavioral thermoregulation of female tilapia during the prespawning phase.
The Journal of experimental zoology 20021001
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Metachlorophenylpiperazine (m-CPP) induced intracavernous pressure responses in anaesthetized rats.
International journal of impotence research 20020801
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Participation of 5-HT(1B) receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5-HT(1B) receptor knockout mice.
British journal of pharmacology 20020801
-
Full substitution of the discriminative cue of a 5-HT(1A/1B/2C) agonist with the combined administration of a 5-HT(1B/2C) and a 5-HT(1A) agonist.
Behavioural pharmacology 20020701
-
The atypical 5-HT2 receptor mediating tachycardia in pithed rats: pharmacological correlation with the 5-HT2A receptor subtype.
British journal of pharmacology 20020301
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Effects of serotine receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic study.
Journal of neurochemistry 20020301
-
Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP).
Journal of medicinal chemistry 20011108
-
Piperazine-like compounds: a new group of designer drugs-of-abuse on the European market.
Forensic science international 20010915
-
RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity.
British journal of pharmacology 20010901
-
Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats.
Journal of psychopharmacology (Oxford, England) 20010301
-
Serotonergic modulation of retinal input to the mouse suprachiasmatic nucleus mediated by 5-HT1B and 5-HT7 receptors.
Journal of biological rhythms 20010201
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Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists.
Pharmacology, biochemistry, and behavior 20010101
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The role of serotonin(2) receptors in mediating cocaine-induced convulsions.
Pharmacology, biochemistry, and behavior 20000401
-
Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors.
Synapse (New York, N.Y.) 20000201
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The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.
European journal of pharmacology 19970501
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Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors.
Journal of neurochemistry 19961101
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Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.
Journal of neurochemistry 19960101
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Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission.
European journal of pharmacology 19940811
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Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
The Journal of biological chemistry 19930825
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Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Molecular pharmacology 19930801
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Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.
Molecular pharmacology 19930301
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Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization.
Molecular pharmacology 19930301
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Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Molecular pharmacology 19930301
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Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
Proceedings of the National Academy of Sciences of the United States of America 19930115
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Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.
Proceedings of the National Academy of Sciences of the United States of America 19920415
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Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.
Molecular pharmacology 19910801
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In-vivo metabolism in the rat and mouse of antrafenine to 1-m-trifluoromethylphenylpiperazine.
The Journal of pharmacy and pharmacology 19850101
