156329-86-1 | 3-Methoxybicyclo[1.1.1]pentane-1-carboxylic acid

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$215.00	$151.00
250mg	95%	in stock	$364.00	$255.00
1g	95%	in stock	$1,113.00	$779.00

Description

• Catalog Number: AI67309
• Chemical Name: 3-Methoxybicyclo[1.1.1]pentane-1-carboxylic acid
• CAS Number: 156329-86-1
• Molecular Formula: C7H10O3
• Molecular Weight: 142.1525
• MDL Number: MFCD30489919
• SMILES: COC12CC(C1)(C2)C(=O)O

Upstream Synthesis Route

The upstream synthesis of 3-methoxybicyclo[1.1.1]pentane-1-carboxylic acid can be achieved by the following synthetic route:

1. Starting from bicyclo[1.1.1]pentane-1-carboxylic acid as the core structure, carry out a Friedel-Crafts acylation reaction using methoxyacetyl chloride in the presence of a Lewis acid catalyst such as AlCl3. This reaction introduces an acyl group.

2. Apply a Wolff-Kishner reduction to the keto group resulting from the acylation to yield the corresponding methylene compound.

3. Subject the methylene intermediate to an O-methylation reaction using an appropriate methylating agent such as dimethyl sulfate or methyl iodide in the presence of a base to afford the desired 3-methoxybicyclo[1.1.1]pentane-1-carboxylic acid.

Take care to purify the intermediates and the final product through appropriate methods such as column chromatography and recrystallization to ensure the high purity of 3-methoxybicyclo[1.1.1]pentane-1-carboxylic acid. The synthetic route should be optimized for yield and selectivity, and spectroscopic methods such as NMR and MS should be utilized to confirm the structures of the synthesized compounds.